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https://www.readbyqxmd.com/read/28548835/rapid-deposition-of-uniform-polydopamine-coatings-on-nanoparticle-surfaces-with-controllable-thickness
#1
Nazar Orishchin, Cameron C Crane, Matthew Brownell, Tengjiao Wang, Samuel Jenkins, Min Zou, Arun Nair, Jingyi Chen
Polydopamine is a bioinspired, versatile material that can adhere to bulk and nanoscale surfaces made of disparate materials to improve their physical and chemical properties in many applications. The typical methods to coat polydopamine on the nanoparticle substrates usually take several hours to a day. This work successfully applies a dispersion method to form a controllable, uniform coating on a nanoparticle surface within minutes. Using plasmonic Ag nanoparticles as a substrate, the coating thickness can be monitored using a spectroscopic method based on the extinction peak shifts of the Ag nanoparticles...
May 26, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28548494/resource-footprints-are-good-proxies-of-environmental-damage
#2
Zoran J N Steinmann, Aafke M Schipper, Mara Hauck, Stefan Giljum, Gregor Wernet, Mark A J Huijbregts
Environmental footprints are increasingly used to quantify and compare environmental impacts of for example products, technologies, households, or nations. This has resulted in a multitude of footprint indicators, ranging from relatively simple measures of resource use (water, energy, materials) to integrated measures of eventual damage (for example, extinction of species). Yet, the possible redundancies among these different footprints have not yet been quantified. This paper analyzes the relationships between two comprehensive damage footprints and four resource footprints associated with 976 products...
May 26, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28548113/erratum-the-first-complete-genome-sequences-of-the-aci-lineage-the-most-abundant-freshwater-actinobacteria-obtained-by-whole-genome-amplification-of-dilution-to-extinction-cultures
#3
Ilnam Kang, Suhyun Kim, Md Rashedul Islam, Jang-Cheon Cho
This corrects the article DOI: 10.1038/srep42252.
May 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28546308/dentate-gyrus-contributes-to-retrieval-as-well-as-encoding-evidence-from-context-fear-conditioning-recall-and-extinction
#4
Brian E Bernier, Anthony F Lacagnina, Adam Ayoub, Francis Shue, Boris V Zemelman, Franklin B Krasne, Michael R Drew
Dentate gyrus (DG) is widely thought to provide a teaching signal that enables hippocampal encoding of memories, but its role during retrieval is poorly understood. Some data and models suggest that DG plays no role in retrieval; others encourage the opposite conclusion. To resolve this controversy, we evaluated the effects of optogenetic inhibition of dorsal DG during context fear conditioning, recall, generalization, and extinction in male mice. We found that (1) inhibition during training impaired context fear acquisition; (2) inhibition during recall did not impair fear expression in the training context, unless mice had to distinguish between similar feared and neutral contexts; (3) inhibition increased generalization of fear to an unfamiliar context that was similar to a feared one and impaired fear expression in the conditioned context when it was similar to a neutral one; (4) inhibition impaired fear extinction...
May 25, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28545386/evolutionary-radiations-in-the-species-rich-mountain-genus-saxifraga-l
#5
J Ebersbach, J Schnitzler, A Favre, A N Muellner-Riehl
BACKGROUND: A large number of taxa have undergone evolutionary radiations in mountainous areas, rendering alpine systems particularly suitable to study the extrinsic and intrinsic factors that have shaped diversification patterns in plants. The species-rich genus Saxifraga L. is widely distributed throughout the Northern Hemisphere, with high species numbers in the regions adjacent to the Qinghai-Tibet Plateau (QTP) in particular the Hengduan Mountains and the Himalayas. Using a dataset of 297 taxa (representing at least 60% of extant Saxifraga species), we explored the variation of infrageneric diversification rates...
May 25, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28545314/letter-to-the-editor-submitted-in-response-to-the-extinction-of-topical-erythromycin-therapy-for-acne-vulgaris-and-concern-for-the-future-of-topical-clindamycin
#6
T Gupta, K Sardana, B Kumar, H K Gautam
No abstract text is available yet for this article.
May 26, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28544993/muscarinic-receptor-m4-positive-allosteric-modulators-attenuate-central-effects-of-cocaine
#7
Camilla Dall, Pia Weikop, Ditte Dencker, Anna C Molander, Gitta Wörtwein, P Jeffrey Conn, Anders Fink-Jensen, Morgane Thomsen
BACKGROUND: Cocaine addiction is a chronic brain disease affecting neurotransmission. Muscarinic cholinergic receptors modulate dopaminergic signaling in the reward system, and muscarinic receptor stimulation can block direct reinforcing effects of cocaine. Here, we tested the hypothesis that specific muscarinic M4 receptor stimulation can attenuate the discriminative stimulus effects and conditioned rewarding effects of cocaine, measures believed to predict the ability of cocaine and cocaine-associated cues to elicit relapse to drug taking...
May 16, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28543226/interactions-within-and-between-clades-shaped-the-diversification-of-terrestrial-carnivores
#8
Mathias M Pires, Daniele Silvestro, Tiago B Quental
A longstanding debate in evolutionary biology and paleontology is whether ecological interactions such as competition impose diversity dependence on speciation and extinction rates. Here we analyze the fossil record of terrestrial mammalian carnivores in North America and Eurasia using a Bayesian framework to assess whether their diversity dynamics were affected by diversity dependence within and between families (12 in Eurasia, 10 in North America). We found eight instances of within-clade diversity dependence suppressing speciation rates and detected between-clade effects increasing extinction rates in six instances...
May 22, 2017: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/28542896/diverse-responses-of-species-to-landscape-fragmentation-in-a-simple-food-chain
#9
Jinbao Liao, Daniel Bearup, Bernd Blasius
1.Habitat destruction, characterized by habitat loss and fragmentation, is a key driver of species extinction in spatial extended communities. Recently, there has been some progress in the theory of spatial food webs, however to date practically little is known about how habitat configurational fragmentation influences multi-trophic food web dynamics. 2.To explore how habitat fragmentation affects species persistence in food webs, we introduce a modelling framework that describes the site occupancy of species in a tri-trophic system...
May 24, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28542839/how-whales-used-to-filter-exceptionally-preserved-baleen-in-a-miocene-cetotheriid
#10
Felix G Marx, Alberto Collareta, Anna Gioncada, Klaas Post, Olivier Lambert, Elena Bonaccorsi, Mario Urbina, Giovanni Bianucci
Baleen is a comb-like structure that enables mysticete whales to bulk feed on vast quantities of small prey, and ultimately allowed them to become the largest animals on Earth. Because baleen rarely fossilises, extremely little is known about its evolution, structure and function outside the living families. Here we describe, for the first time, the exceptionally preserved baleen apparatus of an entirely extinct mysticete morphotype: the Late Miocene cetotheriid, Piscobalaena nana, from the Pisco Formation of Peru...
May 24, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28542439/host-mediated-inflammatory-influence-on-glioblastoma-multiforme-recurrence-following-high-dose-ionizing-radiation
#11
J Tyson McDonald, Xuefeng Gao, Cole Steber, Jawon Lee Breed, Caitlin Pollock, Lili Ma, Lynn Hlatky
Despite optimal clinical treatment, glioblastoma multiforme (GBM) inevitably recurs. Standard treatment of GBM, exposes patients to radiation which kills tumor cells, but also modulates the molecular fingerprint of any surviving tumor cells and the cross-talk between those cells and the host. Considerable investigation of short-term (hours to days) post-irradiation tumor cell response has been undertaken, yet long-term responses (weeks to months) which are potentially even more informative of recurrence, have been largely overlooked...
2017: PloS One
https://www.readbyqxmd.com/read/28542206/carbonyl-based-blue-autofluorescence-of-proteins-and-amino-acids
#12
Chamani Niyangoda, Tatiana Miti, Leonid Breydo, Vladimir Uversky, Martin Muschol
Intrinsic protein fluorescence is inextricably linked to the near-UV autofluorescence of aromatic amino acids. Here we show that a novel deep-blue autofluorescence (dbAF), previously thought to emerge as a result of protein aggregation, is present at the level of monomeric proteins and even poly- and single amino acids. Just as its aggregation-related counterpart, this autofluorescence does not depend on aromatic residues, can be excited at the long wavelength edge of the UV and emits in the deep blue. Differences in dbAF excitation and emission peaks and intensities from proteins and single amino acids upon changes in solution conditions suggest dbAF's sensitivity to both the chemical identity and solution environment of amino acids...
2017: PloS One
https://www.readbyqxmd.com/read/28540927/regional-differences-in-striatal-neuronal-ensemble-excitability-following-cocaine-and-extinction-memory-retrieval-in-fos-gfp-mice
#13
Joseph Ziminski, Meike C Sieburg, Gabriella Margetts-Smith, Hans S Crombag, Eisuke Koya
Learned associations between drugs of abuse and the drug administration environment play an important role in addiction. In rodents, exposure to a drug-associated environment elicits conditioned psychomotor activation, which may be weakened following extinction learning. While widespread drug-induced changes in neuronal excitability have been observed, little is known about specific changes within neuronal ensembles activated during the recall of drug-environment associations. Using a cocaine conditioned locomotion procedure, the present study assessed the excitability of neuronal ensembles in the nucleus accumbens core and shell (NAc(core) and NAc(shell)), and dorsal striatum (DS) following cocaine conditioning and extinction in Fos-GFP mice that express green fluorescent protein (GFP) in activated neurons (GFP+)...
May 25, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28539954/differential-histone-acetylation-in-sub-regions-of-bed-nucleus-of-the-stria-terminalis-underlies-fear-consolidation-and-extinction
#14
Vandana Ranjan, Sanjay Singh, Sarfraj Ahmad Siddiqui, Sukanya Tripathi, Mohd Yahiya Khan, Anand Prakash
OBJECTIVE: The hallmark of anxiety disorders is excessive fear. Previous studies have suggested that selective neural projections from Basal nucleus of stria terminalis (BNST) to amygdala and vice-versa precisely control the fear learning process. However the exact mechanism how the BNST controls fear consolidation and its extinction is largely unknown. In the present study we observed the changes in the BNST sub-regions following fear conditioning and its extinction. METHODS: The change in the number of positive neurons was determined by immunohistochemistry for Acetyl H3 (Histone 3), Acetyl H4 (Histone 4), cAMP response element binding Protein (CBP) and c-fos in three sub-regions of the BNST namely the anterio-lateral BNST (STLP) and anterio-medial BNST (STMA), and lateral-ventral BNST (STLV) of rats subjected to auditory fear conditioning and extinction...
May 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/28539520/independent-evolution-of-baleen-whale-gigantism-linked-to-plio-pleistocene-ocean-dynamics
#15
Graham J Slater, Jeremy A Goldbogen, Nicholas D Pyenson
Vertebrates have evolved to gigantic sizes repeatedly over the past 250 Myr, reaching their extreme in today's baleen whales (Mysticeti). Hypotheses for the evolution of exceptionally large size in mysticetes range from niche partitioning to predator avoidance, but there has been no quantitative examination of body size evolutionary dynamics in this clade and it remains unclear when, why or how gigantism evolved. By fitting phylogenetic macroevolutionary models to a dataset consisting of living and extinct species, we show that mysticetes underwent a clade-wide shift in their mode of body size evolution during the Plio-Pleistocene...
May 31, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28539416/the-extinction-of-cocaine-seeking-requires-a-window-of-infralimbic-pyramidal-neuron-activity-after-unreinforced-lever-presses
#16
Andrea L Gutman, Kelle E Nett, Caitlin V Cosme, Wensday R Worth, Subhash C Gupta, John A Wemmie, Ryan T LaLumiere
The infralimbic cortex (IL) mediates the extinction learning and active suppression of cocaine-seeking behavior. However, the precise temporal relationship among IL activity, lever pressing, and extinction learning is unclear. To address this issue, we employed activity-guided optogenetics in male Sprague-Dawley rats to optically silence IL pyramidal neurons for 20 s immediately following unreinforced lever presses during early extinction training after cocaine self-administration. Optical inhibition of the IL increased active lever pressing during shortened extinction sessions but did not alter the retention of the extinction learning as assessed in ensuing extinction sessions with no optical inhibition...
May 24, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28537967/nortriptyline-enhances-morphine-conditioned-place-preference-in-neuropathic-rats-role-of-the-central-noradrenergic-system
#17
Wenli Mi, Shuxing Wang, Zerong You, Grewo Lim, Michael F McCabe, Hyangin Kim, Lucy Chen, Jianren Mao
BACKGROUND: Combination drug therapy is commonly used to treat chronic pain conditions such as neuropathic pain, and antidepressant is often used together with opioid analgesics. While rewarding is an intrinsic property of opioid analgesics, it is unknown whether the use of an antidepressant would influence opioid reward, which may contribute to opioid addiction. In this study, we examined whether nortriptyline (a tricyclic antidepressant and a first-line medication for neuropathic pain) would enhance the morphine rewarding property in both naive and chronic constriction sciatic nerve injury (CCI) rats...
May 19, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28537636/electromagnetic-field-coupling-characteristics-in-graphene-plasmonic-oligomers-from-isolated-to-collective-modes
#18
Junbo Ren, Weibin Qiu, Houbo Chen, Pingping Qiu, Zhili Lin, Jia-Xian Wang, Qiang Kan, Jiao-Qing Pan
In this paper, we propose a plasmonic tetramer composed of coupled graphene nanodisks. The transformation from the isolated to the collective modes of the proposed structure is investigated by analysing the whispering-gallery modes and extinction spectra with various inter-nanodisk gap distances. In addition, the effect of introducing a central nanodisk into the tetramer on the extinction spectra is explored, which leads to Fano resonance. Furthermore, the refractive index sensing properties of the proposed graphene plasmonic oligomer have been demonstrated...
May 24, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28536511/aripiprazole-facilitates-extinction-of-conditioned-fear-in-adolescent-rats
#19
Despina E Ganella, Liubov Lee-Kardashyan, Sophia J Luikinga, Danny L D Nguyen, Heather B Madsen, Isabel C Zbukvic, Russell Coulthard, Andrew J Lawrence, Jee Hyun Kim
Anxiety disorders are the most common type of mental disorder during adolescence, which is at least partly due to the resistance to extinction exhibited at this age. The dopaminergic system is known to be dysregulated during adolescence; therefore, we aimed to facilitate extinction in adolescent rats using the dopamine receptor 2 partial agonist aripiprazole (Abilify™), and examine the behavioral and neural outcomes. Adolescent rats were conditioned to fear a tone. The next day, rats received extinction 30 min after a systemic injection of either 5 mg/kg aripiprazole or vehicle, and then were tested the following day...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28534584/composition-dependent-electronic-energy-relaxation-dynamics-of-metal-domains-as-revealed-by-bimetallic-au144-xagx-sc8h9-60-monolayer-protected-clusters
#20
Hongjun Zheng, Marcus A Tofanelli, Christopher J Ackerson, Kenneth L Knappenberger
We examined the electronic relaxation dynamics for mono and bimetallic Au144-xAgx(SC8H9)60 monolayer-protected clusters (MPCs) using femtosecond time-resolved transient extinction spectroscopy. MPCs provide compositionally well-defined model systems for structure-specific determination of nanoscale electronic properties. Based on pulse-energy-dependent transient extinction data, we quantified electron-phonon coupling constants for three distinct Au144-xAgx(SC8H9)60 MPC samples, where x = 0, 0 < x < 30, and x ∼ 30, as Gx=0 = (1...
May 23, 2017: Physical Chemistry Chemical Physics: PCCP
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