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https://www.readbyqxmd.com/read/29329121/technique-for-preparing-ultrathin-and-nanothin-descemet-stripping-automated-endothelial-keratoplasty-tissue
#1
Albert Y Cheung, Joshua H Hou, Peter Bedard, Veronique Grimes, Natalie Buckman, Medi Eslani, Edward J Holland
PURPOSE: To describe and report outcomes of our single-pass microkeratome technique for preparation of ultrathin (UT, ≤100 μm) and nanothin (NT, ≤50 μm) Descemet stripping automated endothelial keratoplasty (DSAEK) grafts. METHODS: To prepare NT-DSAEK grafts, a pachymetry nomogram specific to each technician and individual microkeratome head was developed based on accumulated precut and postcut pachymetry data from previous DSAEK grafts. Mean graft thickness as well as precut and postcut endothelial cell counts (ECCs) of NT-DSAEK, UT-DSAEK, and Descemet membrane endothelial keratoplasty (DMEK) grafts between July 2015 and July 2017 were calculated and compared statistically...
January 11, 2018: Cornea
https://www.readbyqxmd.com/read/29327824/are-there-bilateral-isokinetic-shoulder-rotator-differences-in-basketball-male-players
#2
Thierry Weissland, Maryne Cozette, Clare Doyle, Antoine Gabrion
BACKGROUND: The internal (IR) and external (ER) rotator shoulder strength are often assess in the upper limb sports to prevent a risk of injuries. The purpose of this comparative study was to measure the agonist/antagonist balance of shoulder strength and to determine whether significant differences exist between the dominant and nondominant sides in basketball players compared to a control groups. METHODS: During the championship, 23 elite male-basketball players (BB) and 23 healthy males (CG) were tested bilaterally on a Cybex Norm isokinetic dynamometer in a seated position with 45° shoulder abduction in the scapular plane at 60°...
January 10, 2018: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/29314717/effects-of-streptomycin-administration-on-increases-in-skeletal-muscle-fiber-permeability-and-size-following-eccentric-muscle-contractions
#3
Keishi Hayao, Hiroyuki Tamaki, Kouki Nakagawa, Keigo Tamakoshi, Hideaki Takahashi, Kengo Yotani, Futoshi Ogita, Noriaki Yamamoto, Hideaki Onishi
The purpose of this study was to investigate the preventive effect of streptomycin administration on changes in membrane permeability and the histomorphological characteristics of damaged muscle fibers following eccentric contraction (ECC). Eighteen 7-wk-old male Fischer 344 rats were randomly assigned to three groups: control (Cont), ECC, and ECC with streptomycin (ECC+Str). The tibialis anterior (TA) muscles in both ECC groups were stimulated electrically and exhibited ECC. Evans blue dye (EBD), a marker of muscle fiber damage associated with increased membrane permeability, was injected 24 h before TA muscle sampling...
January 3, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29314344/caries-outcome-following-an-intensive-fluoride-varnish-treatment-regimen-for-children-at-high-risk-for-early-childhood-caries
#4
Agelina E Paek, Yihong Li, Zhemeng Wang, Patrick So, Malvin N Janal, Neal G Herman, Andrew Hopkins, Courtney Chinn
PURPOSE: To evaluate the caries relapse rate for a cohort of 2- to 4-year-old children at high risk of early childhood caries when treated with an intensive fluoride varnish (FV) regimen. METHODS: Eighty paediatric patients were recruited. Forty of these patients were high risk and received the FV treatment (three applications within 2 weeks and additional applications at 1 and 3 months) during 2009-2010. Mutans streptococci (MS) levels in the saliva were evaluated during the treatment period...
January 5, 2018: International Journal of Paediatric Dentistry
https://www.readbyqxmd.com/read/29301848/physiologic-pathologic-and-therapeutic-paracrine-modulation-of-cardiac-excitation-contraction-coupling
#5
REVIEW
Joshua Mayourian, Delaine K Ceholski, David M Gonzalez, Timothy J Cashman, Susmita Sahoo, Roger J Hajjar, Kevin D Costa
Cardiac excitation-contraction coupling (ECC) is the orchestrated process of initial myocyte electrical excitation, which leads to calcium entry, intracellular trafficking, and subsequent sarcomere shortening and myofibrillar contraction. Neurohumoral β-adrenergic signaling is a well-established mediator of ECC; other signaling mechanisms, such as paracrine signaling, have also demonstrated significant impact on ECC but are less well understood. For example, resident heart endothelial cells are well-known physiological paracrine modulators of cardiac myocyte ECC mainly via NO and endothelin-1...
January 5, 2018: Circulation Research
https://www.readbyqxmd.com/read/29299196/extract-of-mouse-embryonic-stem-cells-induces-the-expression-of-pluripotency-genes-in-human-adipose-tissue-derived-stem-cells
#6
Paria Motamen Salehi, Tahereh Foroutan, Arash Javeri, Masoumeh Fakhr Taha
Objectives: In some previous studies, the extract of embryonic carcinoma cells (ECCs) and embryonic stem cells (ESCs) have been used to reprogram somatic cells to more dedifferentiated state. The aim of this study was to investigate the effect of mouse ESCs extract on the expression of some pluripotency markers in human adipose tissue-derived stem cells (ADSCs). Materials and Methods: Human ADSCs were isolated from subcutaneous abdominal adipose tissue and characterized by flow cytometric analysis for the expression of some mesenchymal stem cell markers and adipogenic and osteogenic differentiation...
November 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29290476/feasibility-study-of-a-novel-thoraco-abdominal-aortic-hybrid-device-spider-graft-in-a-translational-pig-model
#7
REVIEW
Eike S Debus, Tilo Kölbel, Anna Duprée, Günter Daum, Harleen L Sandhu, Daniel Manzoni, Sabine H Wipper
BACKGROUND: The hybrid SPIDER-graft consists of a proximal descending aortic stent graft and a conventional six branched Dacron graft for open abdominal aortic repair. Technical feasibility with regard to avoiding thoracotomy and extracorporeal circulation (ECC) during thoraco-abdominal aortic hybrid repair and peri-procedural safety of this novel device are unknown. MATERIAL AND METHODS: This was a feasibility and safety study in domestic pigs (75-85 kg). The abdominal aorta including iliac bifurcation, left renal artery, and visceral arteries were exposed via retroperitoneal access...
December 28, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29290078/is-300-seconds-act-safe-and-efficient-during-miecc-procedures
#8
Adrian Bauer, Harald Hausmann, Jan Schaarschmidt, Michal Szlapka, Martin Scharpenberg, Thomas Eberle, J Michael Hasenkam
INTRODUCTION:  The recommended minimum activated clotting time (ACT) level for cardiopulmonary bypass (CPB) of 480 seconds originated from investigations with bubble oxygenators and uncoated extracorporeal circulation (ECC) systems. Modern minimal invasive ECC (MiECC) systems are completely closed circuits containing a membrane oxygenator and a tip-to-tip surface coating. We hypothesized that surface coating and the "closed-loop" design allow the MiECC to safely run with lower ACT levels and that an ACT level of 300 seconds can be safely applied without thromboembolic complications...
December 31, 2017: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/29285987/anticancer-efficacy-of-tannic-acid-is-dependent-on-the-stiffness-of-the-underlying-matrix
#9
Christopher J Bridgeman, Thuy-Uyen Nguyen, Vipuil Kishore
Tannic acid (TA) has been previously shown to have anticancer potential for breast cancer but its effects on melanoma have not yet been investigated. Similarly, stiffness of the tumor microenvironment is known to have a profound effect on breast cancer metastasis, but little is known about its role on melanoma. The goal of the current study is to investigate the synergistic effects of TA and matrix stiffness on melanoma progression. A375 melanoma cells with metastatic potential were cultured on TA crosslinked uncompacted (soft) and electrochemically compacted (stiff) collagen gels and the effects of TA on gel morphology, mechanical properties, and cellular response (i...
December 29, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29284942/knowledge-and-attitude-about-early-childhood-caries-among-pregnant-mothers-from-low-socioeconomic-status-a-questionnaire-study
#10
Pooja Rajan, Ramesh Krishnan, Suresh Kumar, Suraj Nair
Background: For health and well-being, oral health is an integral component. Unfortunately, many children are afflicted with dental caries at an early age, even those as young as 12 months. By imparting knowledge, awareness among parents about this disease can bring about reduction of early childhood caries (ECC) at an early stage. Aim: The aim of this study was to evaluate knowledge and attitude of expectant mothers about ECC and to reassess the level of knowledge after giving anticipatory guidance...
November 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29284941/a-comparative-evaluation-of-bifidobacteria-levels-in-early-childhood-caries-and-severe-early-childhood-caries
#11
Suraj Nair, V Suresh Kumar, Ramesh Krishnan, Pooja Rajan
Background: Bifidobacteria levels in saliva were found to be significantly correlated in adults with dental caries but less information available in the literature regarding its role in children. Aim: The aim is to compare the salivary levels of Bifidobacteria in children who are caries free with that of early childhood caries (ECC) and severe ECC (S-ECC). Materials and Methods: Saliva was collected using the tongue-loop method from a total of 60 children between the age group of 3-5 years and they were further divided into 3 groups...
November 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29284444/comparison-of-efficacy-between-coaxial-microincision-and-standard-incision-phacoemulsification-in-patients-with-age-related-cataracts-a-meta-analysis
#12
Lijun Wang, Xiao Xiao, Lin Zhao, Yi Zhang, Jianming Wang, Aiyi Zhou, Jianchao Wang, Qian Wu
BACKGROUND: Incision size plays a critical role in the efficacy of cataract surgery, but the available evidence on ideal incision size is inconsistent. In this study, we conducted a meta-analysis to evaluate the efficacy of coaxial microincisional phacoemulsification surgery (MICS) compared with that of standard-incision phacoemulsification surgery (SICS) in patients with age-related cataracts. METHODS: The Cochrane Library (Wiley Online Library), PubMed, Medline, National Knowledge Infrastructure (CNKI), and VIP databases were searched to identify reports of clinical randomized controlled trials (RCTs) comparing MICS to SICS for the treatment of age-related cataracts...
December 29, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29279673/impact-of-preventive-care-orientation-on-caries-status-among-preschool-children
#13
Hisham Yehia El Batawi, Kausar Sadia Fakhruddin
Objective: This study aims to study the impact of preventive care orientation given to caregivers of child daycare centers on their knowledge and on the prevalence of early childhood caries (ECC) among preschool children. Materials and Methods: Caregivers of twenty child daycare centers in Emirate of Sharjah were interviewed and 435 children attending these centers were surveyed for decayed missing filled teeth (dmft). The sample data were analyzed using t-tests and one-way ANOVA to assess the statistical significance of the differences in dmft score found between groups...
October 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/29274486/tellurite-resistance-profiles-and-performance-of-different-chromogenic-agars-for-detection-of-non-o157-shiga-toxin-producing-escherichia-coli
#14
Ruyue Fan, Xiangning Bai, Shanshan Fu, Yanmei Xu, Hui Sun, Hong Wang, Yanwen Xiong
Shiga toxin-producing Escherichia coli (STEC) are globally important food-borne pathogens. The isolation of non-O157 STEC is a significant public health challenge due to the dramatic diversity of their phenotypes and genotypes. In the present study, 476 non-O157 STEC strains representing 95 different O-serogroups were used to evaluate tellurite resistance and the performance of 12 different chromogenic agars. Of 476 strains, only 108 (22.7%) strains showed the minimal inhibitory concentration (MIC) values for potassium tellurite being higher than 4μg/ml, and 96 (20...
December 17, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29262404/candida-albicans-and-early-childhood-caries-a-systematic-review-and-meta-analysis
#15
Jin Xiao, Xuelian Huang, Naemah Alkhers, Hassan Alzamil, Sari Alzoubi, Tong Tong Wu, Daniel A Castillo, Frank Campbell, Joseph Davis, Karli Herzog, Ronald Billings, Dorota T Kopycka-Kedzierawski, Evlambia Hajishengallis, Hyun Koo
Oral Candida albicans has been detected in children with early childhood caries (ECC) and has demonstrated cariogenic traits in animal models of the disease. Conversely, other studies found no positive correlation between C. albicans and caries experience in children, while suggesting it may have protective effects as a commensal organism. Thus, this study aimed to examine whether oral C. albicans is associated with ECC. Seven electronic databases were searched. The data from eligible studies were extracted, and the risk of bias was evaluated...
December 21, 2017: Caries Research
https://www.readbyqxmd.com/read/29250715/long-term-regular-eccentric-exercise-decreases-neuropathic-pain-like-behavior-and-improves-motor-functional-recovery-in-an-axonotmesis-mouse-model-the-role-of-insulin-like-growth-factor-1
#16
Daniel F Martins, Thiago C Martins, Ana Paula Batisti, Larissa Dos Santos Leonel, Franciane Bobinski, Luiz A O Belmonte, Leidiane Mazzardo-Martins, Eduardo Cargnin-Ferreira, Adair R S Santos
Although training programs with regular eccentric (ECC) exercise are more commonly used for improving muscular strength and mobility, ECC exercise effects upon functional recovery of the sciatic nerve has not yet been determined. After sciatic nerve crush, different mice groups were subjected to run on the treadmill for 30 min at a speed of 6, 10, or 14 m/min with - 16° slope, 5 days per week, over 8 weeks. During the training time, neuropathic pain-like behavior (mechanical and cold hyperalgesia) was assessed and functional recovery was determined with the grip strength test and the Sciatic Functional and Static indexes (SFI and SSI)...
December 18, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/29246654/proinflammatory-cytokines-in-early-childhood-caries-salivary-analysis-in-the-mother-children-pair
#17
Cecilia Claudia Costa Ribeiro, Crysthian de Jesus Borges Pachêco, Elizabeth Lima Costa, Lorena Lúcia Costa Ladeira, José Ferreira Costa, Rubenice Amaral da Silva, Cadidja Dayanne Sousa Carmo
HYPOTHESIS: Proinflammatory cytokines are increased in saliva of mother/children pairs with caries. DESIGN: Case-control study involving caries-free children (n = 20) and children with early childhood caries (ECC) (n = 20), and their mothers (n = 40). The maternal variables analyzed were waist circumference (WC), decayed, missing and filled teeth (DMFT) and sugar intake; and in the children were body mass index (BMI), def-t and sugar intake. Salivary levels of VEGF, IL-6 and TNF-α were analyzed of mother/children pairs...
December 12, 2017: Cytokine
https://www.readbyqxmd.com/read/29240699/is-a-good-death-at-the-time-of-animal-slaughter-an-essentially-contested-concept
#18
Qurat ulAin, Terry L Whiting
The phrase "essentially contested concept" (ECC) entered the academic literature in 1956 in an attempt to better characterize certain contentious concepts of political theory. Commonly identified examples of contested concepts are morality, religion, democracy, science, nature, philosophy, and certain types of creative products such as the novel and art. The structure proposed to identify an ECC has proven useful in a wide variety of deliberative discourse in the social, political, and religious arenas where seemingly intractable but productive debates are found...
December 14, 2017: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/29235544/relationship-of-corneal-hysteresis-and-optic-nerve-parameters-in-healthy-myopic-subjects
#19
Kunliang Qiu, Xuehui Lu, Riping Zhang, Geng Wang, Mingzhi Zhang
The association between corneal biomechanical properties and glaucoma is an area of much interest. We determined the relationship between corneal hysteresis (CH) and optic nerve parameters in healthy myopic subjects in the current study. CH was measured with Reichert Ocular Response Analyzer in 108 eyes from 108 healthy myopic subjects. All subjects received retinal nerve fiber layer and optic disc imaging Cirrus HD-OCT, GDx ECC, and Heidelberg Retina Tomograph II. None of the tested optic nerve parameters showed statistical significance with CH by using correlation analysis...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29233730/cyclic-concatenated-genetic-encoder-a-mathematical-proposal-for-biological-inferences
#20
M E Duarte-González, O Y Echeverri, J M Guevara, R Palazzo
The organization of the genetic information and its ability to be conserved and translated to proteins with low error rates have been the subject of study by scientists from different disciplines. Recently, it has been proposed that living organisms display an intra-cellular transmission system of genetic information, similar to a model of digital communication system, in which there is the ability to detect and correct errors. In this work, the concept of Concatenated Genetic Encoder is introduced and applied to the analysis of protein sequences as a tool for exploring evolutionary relationships...
December 9, 2017: Bio Systems
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