keyword
MENU ▼
Read by QxMD icon Read
search

ECC

keyword
https://www.readbyqxmd.com/read/28098854/lsd1-sustains-estrogen-driven-endometrial-carcinoma-cell-proliferation-through-the-pi3k-akt-pathway-via-di-demethylating-h3k9-of-cyclin%C3%A2-d1
#1
Chunqin Chen, Yanan Wang, Shiyu Wang, Yuan Liu, Jiawen Zhang, Yuyao Xu, Zhenbo Zhang, Wei Bao, Sufang Wu
A recent study reported that histone lysine specific demethylase 1 (LSD1, KDM1A) is overexpressed in endometrioid endometrial carcinoma (EEC) and associated with tumor progression as well as poor prognosis. However, the physiological function and mechanism of LSD1 in endometrial cancer (EC) remains largely unknown. In this study, we demonstrate that β-estradiol (E2) treatment increased LSD1 expression via the GPR30/PI3K/AKT pathway in endometrial cancer cells. Both siGPR30 and the PI3K inhibitor LY294002 block this effect...
January 16, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28093270/cardiac-magnetic-resonance-tissue-tracking-in-right-ventricle-feasibility-and-normal-values
#2
Vien T Truong, Komal S Safdar, Dinesh K Kalra, Xuexin Gao, Stephanie Ambach, Michael D Taylor, Ryan Moore, Robin J Taylor, Joshua Germann, Olga Toro-Salazar, John L Jefferies, Cheryl Bartone, Subha V Raman, Tam Ngo, Wojciech Mazur
PURPOSE: To investigate right ventricular (RV) strain in patients without identified cardiac pathology using cardiac magnetic resonance tissue tracking (CMR TT). METHODS: A total of 50 consecutive patients with no identified cardiac pathology were analyzed. RV longitudinal and circumferential strain was assessed by CMR TT. The age range was 4-81years with a median of 32years (interquartile range, 15 to 56years). RESULTS: Analysis time per patient was <5min...
January 13, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28076495/antimicrobial-activity-of-ozone-and-naf-chlorhexidine-on-early-childhood-caries
#3
Marcos Ximenes, Mariane Cardoso, Fernando Astorga, Roland Arnold, Luiz André Pimenta, Ricardo de Sousa Viera
An early childhood carie (ECC) is an extremely destructive form of tooth decay. The aim of this study was to investigate the action of ozone (O3), and the association of sodium fluoride (NaF) with chlorhexidine (CHX) on bacteria related to ECC. Overnight culture of the bacteria was performed. On exponential phase the suspension was adjusted (101-108 CFU/mL). A drop (10μL) of each concentration of bacteria was applied on sheep blood agar plates and treated with O3 (2, 20, 200, and 2,000 ppm); after 18 hours, recovery analysis of CFU verified the reduction of bacterial activity...
January 5, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/28063798/evaluation-of-biological-properties-of-3-3-4-4-benzophenonetetracarboxylic-dianhydride-derivatives-and-their-ability-to-inhibit-hexokinase-activity
#4
Krzysztof Kochel, Mateusz D Tomczyk, Rui F Simões, Tomasz Frączek, Adrian Soboń, Paulo J Oliveira, Krzysztof Z Walczak, Aneta Koceva-Chyła
This investigation has explored the properties of 3,3',4,4'-benzophenonetetracarboxylic dianhydride (BDTA) derivatives with regard to their being prospective inhibitors of hexokinase II (HKII). A pluripotent embryonic carcinoma cell line P19 (ECC), was used as the biological target for newly generated potential inhibitors of HKII. The results obtained from Virtual High-Throughput Screening (VHTS), molecular modeling and biological activity studies showed BDTA to be a promising leading structure with a good binding score and simplest functionalization...
December 25, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28036262/interactive-role-of-diabetes-mellitus-and-female-sex-in-the-risk-of-cholangiocarcinoma-a-population-based-nested-case-control-study
#5
Yan-Jiun Huang, Alexander Th Wu, Hung-Yi Chiou, Ming-Tsang Chuang, Tzu-Ching Meng, Li-Nien Chien, Yun Yen
Diabetes mellitus (DM) has been associated with an increased risk of extrahepatic cholangiocarcinoma (ECC) and intrahepatic cholangiocarcinoma (ICC). However, the role of DM in a population with a lower incidence of ECC remains unclear. We investigated the role of DM and other risk factors for ECC and ICC by conducting a population-based, nested, case-control study in Taiwan, a region with a lower incidence but a higher proportion of ICC. We identified patients who received a diagnosis of cholangiocarcinoma (CC) from the Taiwan Cancer Registry between 2003 and 2009...
December 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/28028837/a-novel-mechanism-of-tandem-activation-of-ryanodine-receptors-by-cytosolic-and-sr-luminal-ca-during-excitation-contraction-coupling-in-atrial-myocytes
#6
Joshua T Maxwell, Lothar A Blatter
In atrial myocytes Ca release during excitation-contraction coupling (ECC) is strikingly different from ventricular myocytes. In many species atrial myocytes lack a transverse tubule system, dividing the sarcoplasmic reticulum (SR) Ca store into the peripheral subsarcolemmnal junctional (j-SR) and the much more abundant central non-junctional (nj-SR) SR. Action potential (AP)-induced Ca entry activates Ca-induced Ca release (CICR) from j-SR ryanodine receptor (RyR) Ca release channels. Peripheral elevation of [Ca]i initiates CICR from nj-SR and sustains propagation of CICR to the cell centre...
December 28, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/28012042/dihydropyridine-receptor-dhpr-cacna1s-congenital-myopathy
#7
Vanessa Schartner, Norma B Romero, Sandra Donkervoort, Susan Treves, Pinki Munot, Tyler Mark Pierson, Ivana Dabaj, Edoardo Malfatti, Irina T Zaharieva, Francesco Zorzato, Osorio Abath Neto, Guy Brochier, Xavière Lornage, Bruno Eymard, Ana Lía Taratuto, Johann Böhm, Hernan Gonorazky, Leigh Ramos-Platt, Lucy Feng, Rahul Phadke, Diana X Bharucha-Goebel, Charlotte Jane Sumner, Mai Thao Bui, Emmanuelle Lacene, Maud Beuvin, Clémence Labasse, Nicolas Dondaine, Raphael Schneider, Julie Thompson, Anne Boland, Jean-François Deleuze, Emma Matthews, Aleksandra Nadaj Pakleza, Caroline A Sewry, Valérie Biancalana, Susana Quijano-Roy, Francesco Muntoni, Michel Fardeau, Carsten G Bönnemann, Jocelyn Laporte
Muscle contraction upon nerve stimulation relies on excitation-contraction coupling (ECC) to promote the rapid and generalized release of calcium within myofibers. In skeletal muscle, ECC is performed by the direct coupling of a voltage-gated L-type Ca(2+) channel (dihydropyridine receptor; DHPR) located on the T-tubule with a Ca(2+) release channel (ryanodine receptor; RYR1) on the sarcoplasmic reticulum (SR) component of the triad. Here, we characterize a novel class of congenital myopathy at the morphological, molecular, and functional levels...
December 23, 2016: Acta Neuropathologica
https://www.readbyqxmd.com/read/28007583/towards-a-privacy-preserving-cohort-discovery-framework-for-clinical-research-networks
#8
Jiawei Yuan, Bradley Malin, François Modave, Yi Guo, William R Hogan, Elizabeth Shenkman, Jiang Bian
BACKGROUND: The last few years have witnessed an increasing number of clinical research networks (CRNs) focused on building large collections of data from electronic health records (EHRs), claims, and patient-reported outcomes (PROs). Many of these CRNs provide a service for the discovery of research cohorts with various health conditions, which is especially useful for rare diseases. Supporting patient privacy can enhance the scalability and efficiency of such processes; however, current practice mainly relies on policy, such as guidelines defined in the Health Insurance Portability and Accountability Act (HIPAA), which are insufficient for CRNs (e...
December 19, 2016: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/27999794/hbv-infection-status-and-the-risk-of-cholangiocarcinoma-in-asia-a-meta-analysis
#9
Hao Zhang, Biqing Zhu, He Zhang, Jianxin Liang, Wenting Zeng
Background. The inconsistent finding was between hepatitis B virus (HBV) infections and cholangiocarcinoma (CCA). This meta-analysis is to explore this relationship in Asia. Methods. A literature search was performed using PubMed, Web of Science, and Cochrane Library to October 30, 2015. Pooled incidence rate and OR with 95% CI were calculated using STATA 11.0. Results. Thirty-nine studies were included. The pooled incidence rate of CCA patients with HBV infection was 31% (95% CI 22%-39%). The pooled OR showed increased risk of CCA incidence with HBV infection (OR = 2...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27998424/-dose-effect-relationship-of-the-stilled-water-with-the-elimination-of-the-exfoliated-cancer-cells-in-the-peritoneal-cavity-during-hepatocellular-carcinoma-resection
#10
J Xu, X F Yu, Y Y Ma, Q S Shao
Objective: The aim of the study was to investigate the dose effect relationship of warm distilled water to remove the exfoliated cancer cells (ECC) in peritoneal cavity in 116 cases of hepatocellular carcinoma. Methods: Positive rates of exfoliated cancer cells in 116 patients with hepatocellular carcinoma were detected before and after the removal of the tumor. The 43 to 45 ℃ distilled water was used by 1 500 ml/time before closing the abdomen, and then 37 ℃ sterile normal saline 200 ml was used for peritoneal lavage and collected for exfoliated cancer cell detection...
December 13, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27994711/oxidant-status-following-cardiac-surgery-with-phosphorylcholine-coated-extracorporeal-circulation-systems
#11
Ali Can Hatemi, Kadir Çeviker, Aybala Tongut, İlhan Özgöl, Murat Mert, Ayşem Kaya
Introduction. Extracorporeal circulation (ECC) related systemic oxidative stress is a well-known entity but the underlying mechanisms are not clearly described. Our aim was to investigate the relation between the oxidative stress indices, inflammatory markers, and phosphorylcholine-coated (PCC) ECC systems. Patients and Methods. Thirty-two consecutive coronary artery bypass grafting (CABG) cases were randomly assigned to Group I (PCC, n = 18) and Group II (noncoated, n = 14) ECC circuits. Total Antioxidant Status (TAS), Total Oxidant Status (TOS), Tumor Necrosis Factor-α (TNF-α), Interleukin-1β (IL-β), Interleukin-6 (IL-6), Interleukin-8 (IL-8), Interleukin-10 (IL-10), and Procalcitonin (PCT) levels were measured at 5 different time points...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27988306/eccentric-exercise-in-ischemic-cardiac-patients-and-functional-capacity-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#12
REVIEW
C Karagiannis, C Savva, I Mamais, M Efstathiou, M Monticone, T Xanthos
BACKGROUND: Eccentric (ECC) exercise is an "economical" type of exercise with low energy requirements and does not cause early fatigue. Therefore, it is used for cardiac patients, who have low physical activity and exercise intolerance, as an easier kind of training. OBJECTIVE: This systematic review aimed to investigate the efficacy of ECC exercise for functional capacity (FC) in patients with ischemic heart disease. DESIGN: Systematic review...
December 14, 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27984654/extended-clearance-classification-system-eccs-informed-approach-for-evaluating-investigational-drugs-as-substrates-of-drug-transporters
#13
M V Varma, A F El-Kattan, B Feng, S J Steyn, T S Maurer, D O Scott, A D Rodrigues, L M Tremaine
No abstract text is available yet for this article.
December 16, 2016: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27979982/role-of-calpain-in-eccentric-contraction-induced-proteolysis-of-ca2-regulatory-proteins-and-force-depression-in-rat-fast-twitch-skeletal-muscle
#14
Keita Kanzaki, Daiki Watanabe, Mai Kuratani, Takashi Yamada, Satoshi Matsunaga, Masanobu Wada
The aim of this study was to examine the in vivo effects of eccentric contraction (ECC) on calpain-dependent proteolysis of Ca(2+)-regulatory proteins and force production in fast-twitch skeletal muscles. Rat extensor digitorum longus muscles were exposed to 200-repeated ECC in situ and excised immediately (recovery 0) or 3 days (recovery 3) after cessation of ECC. Calpain inhibitor (CI)-treated rats were intraperitoneally injected with MDL-28170 before ECC and during 3 days of recovery. Tetanic force was markedly reduced at recovery 0 and remained reduced at recovery 3...
December 15, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27979834/ciclosporin-to-protect-renal-function-in-cardiac-surgery-ciprics-a-study-protocol-for-a-double-blind-randomised-placebo-controlled-proof-of-concept-study
#15
Per Ederoth, Edgars Grins, Alain Dardashti, Björn Brondén, Carsten Metzsch, André Erdling, Shahab Nozohoor, Arash Mokhtari, Magnus J Hansson, Eskil Elmér, Lars Algotsson, Stefan Jovinge, Henrik Bjursten
INTRODUCTION: Acute kidney injury (AKI) after cardiac surgery is common and results in increased morbidity and mortality. One possible mechanism for AKI is ischaemia-reperfusion injury caused by the extracorporeal circulation (ECC), resulting in an opening of the mitochondrial permeability transition pore (mPTP) in the kidneys, which can lead to cell injury or cell death. Ciclosporin may block the opening of mPTP if administered before the ischaemia-reperfusion injury. We hypothesised that ciclosporin given before the start of ECC in cardiac surgery can decrease the degree of AKI...
December 15, 2016: BMJ Open
https://www.readbyqxmd.com/read/27958204/results-and-safety-profile-of-trainee-cataract-surgeons-in-a-community-setting-in-east-africa
#16
Nikolaos Mavrakanas, Kazim A Dhalla, Jerry Jecha, Imani Kapesa, Capucine Odouard, Ian Murdoch
PURPOSE: To evaluate the results and safety profile of assistant medical officer ophthalmologists (AMO-O) performing cataract surgery in the last stage of their surgical training, before their appointment to local communities. METHODS: We retrospectively analyzed the records of patients who underwent cataract surgery by AMO-Os at Dar es Salaam, Comprehensive Community Based Rehabilitation for Tanzania Disability Hospital between September 2008 and June 2011. Surgical options were either extracapsular cataract extraction (ECCE) or manual small incision cataract surgery (MSICS), both with polymethylmethacrylate intraocular lens implantation...
November 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27941252/antenatal-health-care-and-postnatal-dental-check-ups-prevent-early-childhood-caries
#17
Yukie Nakai, Yukako Mori, Izumi Tamaoka
The first stage of early childhood caries (ECC) is infection by mutans streptococci, of which the primary infection source is the child's mother. Early intervention programs including antenatal and postnatal phases are effective for reducing ECC. This study was conducted to assess the respective effects of antenatal health care and postnatal care such as regular dental check-ups on reducing ECC among 3-year-old Japanese children. This nested case-control study of 155 three-year-old children (49.0% boys) was conducted at a dental clinic that provides collaborative health services with the Obstetrics and Gynecology Clinic, Okayama...
2016: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27931421/policy-on-early-childhood-caries-ecc-unique-challenges-and-treatment-options
#18
(no author information available yet)
No abstract text is available yet for this article.
October 2016: Pediatric Dentistry
https://www.readbyqxmd.com/read/27931420/policy-on-early-childhood-caries-ecc-classifications-consequences-and-preventive-strategies
#19
(no author information available yet)
No abstract text is available yet for this article.
October 2016: Pediatric Dentistry
https://www.readbyqxmd.com/read/27923355/oral-health-related-quality-of-life-and-early-childhood-caries-among-preschool-children-in-trinidad
#20
Rahul Naidu, June Nunn, Erica Donnelly-Swift
BACKGROUND: Early childhood caries (ECC) is a public health problem in developed and developing countries. The purpose of this study was to describe the relationship between oral health-related quality of life (OHRQoL) and ECC among preschool children in a Caribbean population. METHOD: Parents/primary caregivers of children attending nine, randomly selected preschools in central Trinidad were invited to complete an oral health questionnaire and have their child undertake an oral examination...
December 7, 2016: BMC Oral Health
keyword
keyword
18139
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"