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https://www.readbyqxmd.com/read/28647188/mir-200a-and-mir-200b-target-pten-to-regulate-the-endometrial-cancer-cell-growth-in%C3%A2-vitro
#1
Qiang Wu, Ren-Lian Lu, Jing-Xiang Li, Li-Jun Rong
OBJECTIVE: To study whether miR-200a and miR-200b target PTEN gene expression to regulate the endometrial cancer cell growth in vitro. METHODS: Endometrial cancer cells ECC-1 were cultured and transfected with the miR-200a and miR-200b mimics and inhibitors as well as the negative control mimics and inhibitors, and then the cell proliferation activity as well as the expression of PTEN and downstream genes in cells was determined; after transfection of miR-200a and miR-200b mimics as well as PTEN-3'UTR luciferase report gene plasmids, the fluorescence activity of luciferase reporter gene was determined...
May 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28643162/dental-caries-a-disease-which-needs-attention
#2
Vijay Prakash Mathur, Jatinder Kaur Dhillon
Dental caries is one of the most prevalent disease (about 50%) in children across the globe. If not treated in time, it can affect not only the mastication function but also the speech, smile and psychosocial environment and the quality of life of the child and the family. The treatment of dental diseases is very expensive in all countries and prevention is very simple and effective. The caries in children below 6 y is called early childhood caries (ECC). It is most commonly caused by milk bottle or mother's feed during night...
June 23, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28642749/rna-seq-reveals-enhanced-sugar-metabolism-in-streptococcus-mutans-co-cultured-with-candida-albicans-within-mixed-species-biofilms
#3
Jinzhi He, Dongyeop Kim, Xuedong Zhou, Sang-Joon Ahn, Robert A Burne, Vincent P Richards, Hyun Koo
Early childhood caries (ECC), which can lead to rampant tooth-decay that is painful and costly to treat, is one of the most prevalent infectious diseases affecting children worldwide. Previous studies support that interactions between Streptococcus mutans and Candida albicans are associated with the pathogenesis of ECC. The presence of Candida enhances S. mutans growth, fitness and accumulation within biofilms in vitro, although the molecular basis for these behaviors is undefined. Using an established co-cultivation biofilm model and RNA-Seq, we investigated how C...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28639687/risk-indicators-of-early-childhood-caries-ecc-in-children-with-high-treatment-needs
#4
Iris Kraljevic, Cornelia Filippi, Andreas Filippi
Early childhood caries (ECC) represents a major health and economic problem worldwide. Its consequences such as early pain experience may affect the immediate and long-term quality of life of the child. In very young and uncooperative children the therapy of ECC is often viable only under general anesthesia. After treatment these affected children have a higher risk for future caries either soon thereafter, or later in life. The aim of the present study was to determine risk indicators and their correlation among children with high caries prevalence and high treatment needs, in order to facilitate the development of targeted prophylaxis programs that would reduce future occurrences of ECC or at least positively influence the outcome...
2017: Swiss Dental Journal
https://www.readbyqxmd.com/read/28637599/isokinetic-clinical-assessment-of-rotator-cuff-strength-in-subacromial-shoulder-impingement
#5
Helen Land, Susan Gordon, Kerrianne Watt
BACKGROUND: Current conservative management of subacromial shoulder impingement (SSI) includes generic strengthening exercises, especially for internal (IR) and external (ER) shoulder rotators. However, there is no evidence that the strength or the ratio of strength between these muscle groups is different between those with SSI (cases) and an asymptomatic population (controls). OBJECTIVE: To identify if isokinetic rotator cuff strength or the ratio of strength is significantly different between cases and controls...
February 2017: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/28631283/assessing-causal-effects-of-early-life-course-factors-on-early-childhood-caries-in-5-year-old-ugandan-children-using-directed-acyclic-graphs-dags-a-prospective-cohort-study
#6
Nancy Birungi, Lars T Fadnes, Arabat Kasangaki, Victoria Nankabirwa, Isaac Okullo, Stein A Lie, James K Tumwine, Anne N Åstrøm
OBJECTIVE: To estimate the effect of distal and proximal early life-course factors on early childhood caries (ECC) in 5-year-old Ugandan children, particularly focusing on the causal effect of exclusive breast feeding (EBF) on ECC using directed acyclic graphs (DAGs) for confounder selection. METHODS: This study had a nested prospective cohort design, focusing on 5 years of follow-ups of caregiver-children pairs from the PROMISE-EBF trial (ClinicalTrials.gov no: NCT00397150) conducted in 2011 in Eastern Uganda...
June 20, 2017: Community Dentistry and Oral Epidemiology
https://www.readbyqxmd.com/read/28628842/matching-genomic-molecular-aberrations-with-molecular-targeted-agents-are-biliary-tract-cancers-an-ideal-playground
#7
REVIEW
Loic Verlingue, Antoine Hollebecque, Valérie Boige, Michel Ducreux, David Malka, Charles Ferté
Biliary tract cancers (BTCs) are a heterogeneous group of tumours with geographical discrepancies in terms of incidence and risk factors. However, a convergent genomic and epigenetic mutational landscape emerges from the genome-wide screens of BTCs in South East Asia, Latin America and in the Western World. Specificities are observed for some alterations and anatomical subtypes: frequent fibroblast growth factor receptor 2 (FGFR2) and isocitrate dehydrogenase 1/2 (IDH1/2) alterations are specific to intrahepatic cholangiocarcinomas (ICCs), whereas frequent ERBB2 oncogene alterations are specific to extrahepatic cholangiocarcinomas (ECCs) and gallbladder carcinomas (GBCs)...
June 16, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28617874/candida-albicans-mannans-mediate-streptococcus-mutans-exoenzyme-gtfb-binding-to-modulate-cross-kingdom-biofilm-development-in-vivo
#8
Geelsu Hwang, Yuan Liu, Dongyeop Kim, Yong Li, Damian J Krysan, Hyun Koo
Candida albicans is frequently detected with heavy infection by Streptococcus mutans in plaque-biofilms from children with early-childhood caries (ECC). This cross-kingdom biofilm contains an extensive matrix of extracellular α-glucans that is produced by an exoenzyme (GtfB) secreted by S. mutans. Here, we report that mannans located on the outer surface of C. albicans cell-wall mediates GtfB binding, enhancing glucan-matrix production and modulating bacterial-fungal association within biofilms formed in vivo...
June 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28616343/debranching-aortic-surgery
#9
REVIEW
Manuel Alonso Pérez, José Manuel Llaneza Coto, José Antonio Del Castro Madrazo, Carlota Fernández Prendes, Mario González Gay, Amer Zanabili Al-Sibbai
Conventional open surgery still remains as the gold standard of care for aortic arch and thoracoabdominal pathology. In centers of excellence, open repair of the arch has been performed with 5% immediate mortality and a low rate of complications; however overall mortality rates are around 15%, being up to 40% of all patients rejected for treatment due to their age or comorbidities. For thoracoabdominal aortic pathology, data reported from centers of excellence show immediate mortality rates from 5% to 19%, spinal cord ischemia from 2...
May 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28609641/flexibility-training-and-the-repeated-bout-effect-priming-interventions-prior-to-eccentric-training-of-the-knee-flexors
#10
Andrew W Leslie, Joel L Lanovaz, Justin W Andrushko, Jonathan P Farthing
Both the repeated bout effect and increased flexibility have been linked to reduced muscle damage, fatigue and strength loss after intense eccentric exercise. Our purpose was to compare the eccentric training (ECC) response after first priming the muscles with either static flexibility training or a single intense bout of eccentric exercise. Twenty-five participants were randomly assigned to flexibility training (F;n=8; 3x/week; 30 min/day), a single-bout of intense eccentric exercise (SB;n=9), or no intervention (control [C];n=8) during a 4-week priming phase, prior to completing a subsequent 4-week period of eccentric training of the knee flexors...
June 13, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28608117/can-we-define-the-risk-of-lymph-node-metastasis-in-early-stage-cervical-cancer-patients-a-large-scale-retrospective-study
#11
Gabriella Ferrandina, Luigi Pedone Anchora, Valerio Gallotta, Anna Fagotti, Enrico Vizza, Vito Chiantera, Pierandrea De Iaco, Alfredo Ercoli, Giacomo Corrado, Carolina Bottoni, Francesco Fanfani, Giovanni Scambia
BACKGROUND: Sentinel lymph node (SLN) biopsy has emerged as one of the most appreciated techniques for reducing the rate of complete lymph node dissection (LND) performed in patients with early-stage cervical cancer (ECC). However, its performances are still a matter of debate and, to improve them, international guidelines recommend performing at least unilateral LND in case of SLN mapping. In a prior study, we identified a group of patients without evidence of lymph node metastasis (LNM)...
June 12, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28596973/quadriceps-strength-in-patients-with-isolated-cartilage-defects-of-the-knee-results-of-isokinetic-strength-measurements-and-their-correlation-with-clinical-and-functional-results
#12
Anja Hirschmüller, Tasja Andres, Wolfgang Schoch, Heiner Baur, Lukas Konstantinidis, Norbert P Südkamp, Philipp Niemeyer
BACKGROUND: Recent studies have found a significant deficit of maximum quadriceps strength after autologous chondrocyte implantation (ACI) of the knee. However, it is unclear whether muscular strength deficits in patients with cartilage damage exist prior to operative treatment. PURPOSE: To isokinetically test maximum quadriceps muscle strength and quantify the impact of possible strength deficits on functional and clinical test results. STUDY DESIGN: Cross-sectional study; Level of evidence, 3...
May 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28593716/does-an-epidemiological-comparison-support-a-common-cellular-lineage-for-similar-subtypes-of-postmenopausal-uterine-and-ovarian-carcinoma-the-norwegian-women-and-cancer-study
#13
Mie Jareid, Idlir Licaj, Karina Standahl Olsen, Eiliv Lund, Hege M Bøvelstad
Uterine and ovarian carcinomas have the same major histological subtypes, but whether they originate from the same cell types is a matter of ongoing debate. Uterine and ovarian endometrioid and clear cell carcinoma (ECC) and uterine and ovarian serous carcinoma (SC) may originate in the same location, or share a common lineage of differentiation. Epidemiologically, a common cellular lineage should be reflected in similar risk associations, and we explored the similarity of uterine and ovarian ECC and uterine and ovarian SC...
June 8, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28592259/safety-of-low-molecular-weight-heparin-compared-to-unfractionated-heparin-in-hemodialysis-a-systematic-review-and-meta-analysis
#14
Hind Harrak Lazrak, Émilie René, Naoual Elftouh, Martine Leblanc, Jean-Philippe Lafrance
BACKGROUND: Low molecular weight heparins (LMWH) have been extensively studied and became the treatment of choice for several indications including pulmonary embolism. While their efficacy in hemodialysis is considered similar to unfractionated heparin (UFH), their safety remains controversial mainly due to a risk of bioaccumulation in patients with renal impairment. The aim of this systematic review was to evaluate the safety of LMWH when compared to UFH for extracorporeal circuit (ECC) anticoagulation...
June 7, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28590926/transcriptional-factor-oct4-promotes-esophageal-cancer-metastasis-by-inducing-epithelial-mesenchymal-transition-through-vegf-c-vegfr-3-signaling-pathway
#15
Chunguang Li, Maoling Zhu, Xiaoli Lou, Chunying Liu, Hezhong Chen, Xuejing Lin, Weidan Ji, Zhigang Li, Changqing Su
The octamer-binding transcription factor 4 (OCT4) can promote cancer proliferation and metastasis. Esophageal carcinoma (ECC) harbors different quantities of OCT4-positive cancer cells. These cells are highly malignant and prone to metastasis; however, the mechanism remains unknown. In this study, we found that OCT4 enhances vascular endothelial growth factor C (VEGF-C) promoter activity to promote VEGF-C expression and activates VEGF receptor 3 (VEGFR-3) in ECC cells, thereby inducing cancer cell epithelial-mesenchymal transition (EMT)...
May 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28589201/magnesia-stabilised-zirconia-solid-electrolyte-assisted-electrochemical-investigation-of-iron-ions-in-a-sio2-cao-mgo-al2o3-molten-slag-at-1723-k
#16
Yunming Gao, Chuanghuang Yang, Canlei Zhang, Qingwei Qin, George Z Chen
Production of metallic iron through molten oxide electrolysis using inert electrodes is an alternative route for fast ironmaking without CO2 emissions. The fact that many inorganic oxides melt at ultrahigh temperatures (>1500 K) challenges conventional electro-analytical techniques used in aqueous, organic and molten salt electrolytes. However, in order to design a feasible and effective electrolytic process, it is necessary to best understand the electrochemical properties of iron ions in molten oxide electrolytes...
June 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28588427/evaluation-of-anti-fatigue-property-of-the-extruded-product-of-cereal-grains-mixed-with-cordyceps-militaris-on-mice
#17
Lei Zhong, Liyan Zhao, Fangmei Yang, Wenjian Yang, Yong Sun, Qiuhui Hu
BACKGROUND: Fatigue is a biological phenomenon that involves a feeling of extreme physical or mental tiredness that could potentially cause some severe chronic diseases. Recently, diet therapy has provided a new alternative to alleviate physical fatigue. In our previous study, addition of Cordyceps militaris (C. militaris) into an extruded product was shown to provide high nutrition and unique flavors; however, little is known whether this product has some scientific evidence regarding anti-fatigue property...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28582490/impact-of-minimally-invasive-extracorporeal-circuits-on-octogenarians-undergoing-coronary-artery-bypass-grafting-have-we-been-looking-in-the-wrong-direction-%C3%A2
#18
Aschraf El-Essawi, Ingo Breitenbach, Benjamin Haupt, Rene Brouwer, Hassina Baraki, Wolfgang Harringer
OBJECTIVES: Minimally invasive extracorporeal circuits (MiECCs) aim at the preservation of physiologic reserves, the impact of which is expected to be most evident in patients in whom these are depleted. In this context, octogenarians present a subpopulation of specific interest. METHODS: Based on the type of the utilized ECC, we performed a retrospective comparison between all octogenarians ( n  = 324) who received a primary coronary artery bypass in our institution from 2003 until 2010...
June 3, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28579141/diagnostic-potential-of-inflammatory-biomarkers-in-early-childhood-caries-a-case-control-study
#19
Vrinda Sharma, Nidhi Gupta, Nikhil Srivastava, Vivek Rana, Preetika Chandna, Savita Yadav, Alpana Sharma
BACKGROUND: Early Childhood Caries (ECC) is most common chronic infectious disease of childhood. Diagnosis of dental caries has been limited to clinical, visual and radiographic methods but its inflammatory component remained unexplored. Hence, this study aims to evaluate salivary levels of inflammatory cytokines in children with ECC to assess their potential as non-invasive biomarkers. METHODS: 50 subjects were recruited (25 ECC patients and 25 healthy children)...
June 1, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28573263/risk-factors-associated-with-early-childhood-caries
#20
Hui Bin Sun, Wei Zhang, Xiao Bin Zhou
OBJECTIVE: To analyse factors associated with the susceptibility of early childhood caries (ECC), populations with a high risk of ECC were screened and guidance for ECC prevention was proposed. METHODS: A total of 392 children aged 24 to 71 months were selected for oral examination in Qingdao. Parents or guardians of the participants completed the questionnaires and decayed missing filled surface (dmfs) were recorded. Differences in caries condition and oral health behaviour in different families were compared...
2017: Chinese Journal of Dental Research
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