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Chang Ho Lee, So Young Kim, Hyoung-Mi Kim, Young Ju Kim, Ji Yoon Kim, Mi Kyung Kim
OBJECTIVES: To study the influence of the cochleariform process abutment (CPA) of early congenital cholesteatomas (CC) (ECCs) on surgical outcomes. STUDY DESIGN: Retrospective case review. SETTING: University hospital otology referral clinic. PATIENTS: Two hundred consecutive pediatric ECC patients. INTERVENTIONS: The patients were classified into three groups based on the temporal bone computed tomography (TBCT) findings of ECC: A) the absence of CPA, B) the presence of CPA, and C) the presence of CPA and extension posterior to the malleus handle...
October 12, 2016: Otology & Neurotology
Jürgen Bohlender, Jürg Nussberger, Beate Bohlender
OBJECTIVE: In elderly hypertensive patients, systolic blood pressure (sBP) goals recommended by US and European guidelines (ESH) for the initiation of treatment are more liberal than in younger patients because of an increased risk of treatment-associated side-effects and hypotension. Carotid stenosis increases with age and poses a risk of brain ischemia if hypotension occurs. Its relevance for the routine care of elderly hypertensives, however, remains unclear. We analyzed data on precerebral artery morphology and BP evolution from a survey of aged hospitalized patients...
September 2016: Journal of Hypertension
Rulin Sun, Santao Zhang, Xing Lu, Wenjun Hu, Ning Lou, Yan Zhao, Jia Zhou, Xiaoping Zhang, Hongmei Yang
Cancer-induced muscle wasting, which commonly occurs in cancer cachexia, is characterized by impaired quality of life and poor patient survival. To identify an appropriate treatment, research on the mechanism underlying muscle wasting is essential. Thus far, studies on muscle wasting using cancer cachectic models have generally focused on early cancer cachexia (ECC), before severe body weight loss occurs. In the present study, we established models of ECC and late cancer cachexia (LCC) and compared different stages of cancer cachexia using two cancer cachectic mouse models induced by colon-26 (C26) adenocarcinoma or Lewis lung carcinoma (LLC)...
October 12, 2016: Oncology Reports
Francesco Gaetano Casino, Carlo Basile
BACKGROUND: The recent interest in incremental haemodialysis (HD) is hindered by the current prescription based on a fixed target model (FTM) for the total (dialytic + renal) equivalent continuous clearance (ECC). The latter is expressed either as standard Kt/V (stdKt/V), i.e. the pre-dialysis averaged concentration of urea-based ECC, or EKRc, i.e. the time averaged concentration-based ECC, corrected for volume (V) = 40 L. Accordingly, there are two different targets: stdKt/V = 2.3 volumes per week (v/wk) and EKRc = 13 mL/min/40 L...
October 14, 2016: Nephrology, Dialysis, Transplantation
Marcus J Goudie, Benjamin M Brainard, Chad W Schmeidt, Hitesh Handa
Infection and thrombosis are the two leading complications associated with blood contacting medical devices, and have led to active materials that can delivery antibiotics or antithrombotic agents. Two key characteristics of these materials are the ability to produce controlled delivery, as well as minimal systemic delivery of the agent outside of the device site. Nitric oxide (NO) releasing materials are attractive as NO plays pivotal roles in the body's natural defense against bacterial infection, as well as regulation of platelet adhesion and activation...
October 14, 2016: Journal of Biomedical Materials Research. Part A
Jin Xiao, Yonghwi Moon, Lihua Li, Elena Rustchenko, Hironao Wakabayashi, Xiaoyi Zhao, Changyong Feng, Steven R Gill, Sean McLaren, Hans Malmstrom, Yanfang Ren, Robert Quivey, Hyun Koo, Dorota T Kopycka-Kedzierawski
INTRODUCTION: Candida albicans has been detected together with Streptococcus mutans in high numbers in plaque-biofilm from children with early childhood caries (ECC). The goal of this study was to examine the C. albicans carriage in children with severe early childhood caries (S-ECC) and the maternal relatedness. METHODS: Subjects in this pilot cross-sectional study were recruited based on a convenient sample. DMFT(S)/dmft(s) caries and plaque scores were assessed during a comprehensive oral exam...
2016: PloS One
Gert Ulrich, Mario Parstorfer
PURPOSE: There is limited data on postactivation potentiation (PAP) effects following plyometric conditioning contractions (CC), especially in the upper body. Therefore, the study compared plyometric CC with concentric-eccentric and eccentric CC aiming to improve upper body power performance due to a PAP-effect. METHODS: Sixteen resistance-trained males completed three experimental trials in a randomized order which composed of either a plyometric (PLY), a concentric-eccentric (CON) or an eccentric-only (ECC) CC...
October 13, 2016: International Journal of Sports Physiology and Performance
Sebastian Bachmann, Björn Gernert, Dietmar Stalke
In this paper we present the aggregational motifs of the widely used alkali-metal cyclopentadienides (CpLi, CpNa, CpK, CpRb, CpCs) in THF-d8 solution estimated by ECC-DOSY NMR spectroscopy. They form monomeric contact ion pairs (CIPs) in THF-d8 solution, whereas in NH3 solvent-separated ion pairs (SSIPs) are observed. The applicability of ECC-DOSY is further advanced by introducing ECC-MW estimation software.
October 12, 2016: Chemical Communications: Chem Comm
Youngjin Kim, Hyeongseok Kim, Ung Hyun Ko, Youjin Oh, Ajin Lim, Jong-Woo Sohn, Jennifer H Shin, Hail Kim, Yong-Mahn Han
Insulin secretion is elaborately modulated in pancreatic ß cells within islets of three-dimensional (3D) structures. Using human pluripotent stem cells (hPSCs) to develop islet-like structures with insulin-producing ß cells for the treatment of diabetes is challenging. Here, we report that pancreatic islet-like clusters derived from hESCs are functionally capable of glucose-responsive insulin secretion as well as therapeutic effects. Pancreatic hormone-expressing endocrine cells (ECs) were differentiated from hESCs using a step-wise protocol...
October 12, 2016: Scientific Reports
Matthias Heringlake, Efstratios I Charitos, Kira Erber, Astrid Ellen Berggreen, Hermann Heinze, Hauke Paarmann
BACKGROUND: Growth-differentiation factor-15 (GDF-15) is an emerging humoral marker for risk stratification in cardiovascular disease. Cardiac-surgery-associated acute kidney injury (CSA-AKI), an important complication in patients undergoing cardiac surgery, is associated with poor prognosis. The present secondary analysis of an observational cohort study aimed to determine the role of GDF-15 in predicting CSA-AKI compared with the Cleveland-Clinic Acute Renal Failure (CC-ARF) score and a logistic regression model including variables associated with renal dysfunction...
October 8, 2016: Critical Care: the Official Journal of the Critical Care Forum
Vipuil Kishore, Ranjani Iyer, Athela Frandsen, Thuy-Uyen Nguyen
Loss of vision due to corneal disease is a significant problem worldwide. Transplantation of donor corneas is a viable treatment option but limitations such as short supply and immune-related complications call for alternative options for the treatment of corneal disease. A tissue engineering-based approach using a collagen scaffold is a promising alternative to develop a bioengineered cornea that mimics the functionality of native cornea. In this study, an electrochemical compaction method was employed to synthesize highly dense and transparent collagen matrices...
October 6, 2016: Biomedical Materials
Martin Laasmaa, Rikke Birkedal, Marko Vendelin
In cardiac excitation-contraction coupling (ECC), calcium enters the cytosol via L-type Ca(2+) channels (LTCC) and reverse Na(+)/Ca(2+)-exchange (NCXrev), or is released from the sarcoplasmic reticulum (SR) by Ca(2+)-induced Ca(2+)-release (CICR). The magnitude of Ca(2+) influx via the different pathways varies with the state of the cell and is difficult to assess quantitatively, because changes in Ca(2+) influx through one pathway affects the others. In rainbow trout ventricular myocytes, the role of the SR has been uncertain for decades...
October 1, 2016: Journal of Molecular and Cellular Cardiology
Øyvind Sverre Svendsen, Ketil Grong, Knut Sverre Andersen, Paul Husby
BACKGROUND: Accidental hypothermia with arrested circulation remains a condition associated with high mortality. In our institution, extracorporeal circulation (ECC) rewarming has been the cornerstone in treating such patients since 1987. We here explore characteristics and outcomes of this treatment, to identify significant merits and challenges from 3 decades of experience in ECC rewarming. METHODS: Sixty-nine patients rewarmed by ECC during the period from December 1987 to December 2015 were analyzed...
September 27, 2016: Annals of Thoracic Surgery
James Peter Fisher, Luke Carlson, James Steele
Research has produced equivocal results with regard to eccentric (ECC) only compared with traditional concentric/eccentric resistance training (RT). When considered in relation to load- and repetition duration-accentuated (ECC) training as well as the use of isokinetic and isoinertial training methods, there is a relative dearth of literature considering multi-joint, multi-exercise RT interventions. The present study considered 59 male and female participants randomly divided in to 3 sex counterbalanced groups; ECC only (ECC, n = 20), repetition duration-accentuated ECC (ECC-A, n = 20), and traditional (CON, n = 19) performing full-body, effort matched RT programmes for 2 days·week(-1) for 10 weeks...
June 22, 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
Fawad Javed, Changyong Feng, Dorota T Kopycka-Kedzierawski
The aim was to systemically review the incidence of early childhood caries (ECC). The addressed focused question was "What is the reported incidence of ECC?" Indexed databases were searched using various key words. Five studies were included and processed for data extraction. All studies were prospective and two studies were randomized clinical trials. The number of participants ranged between 96 and 1275 children. Two studies reported the mean age of children, that ranged between 1.8 and 2.5 years (range 0...
September 29, 2016: Journal of Investigative and Clinical Dentistry
Maryne Cozette, Stéphane Delanaud, Pierre-Marie Lepretre, Thierry Weissland
OBJECTIVE: Shoulder internal (IR) and external rotator (ER) muscles play an important role in the stability of glenohumeral joint. The ratio between the peak torque of ER and IR in concentric (ER/IRPT) and mixed (ER-ECC/IR-CONPT) are usually measured to evaluate the effects of muscle weakness, sport activities, injury and treatment (Greenfield et al., 1990; Scoville et al., 1997). However, ER/IRPT and ER-ECC/IR-CONPT failed to provide some indication on the evolution of the ER/IR torque ratio (ER/IRTorque) and mixed torque ratio (ER-EC/IR-COTorque) during the range of motion (ROM)...
September 2016: Annals of Physical and Rehabilitation Medicine
Madushini N Dharmasena, Catherine M Feuille, Carly Elizabeth C Starke, Arvind A Bhagwat, Scott Stibitz, Dennis J Kopecko
The licensed oral, live-attenuated bacterial vaccine for typhoid fever, Salmonella enterica serovar Typhi strain Ty21a, has also been utilized as a vaccine delivery platform for expression of diverse foreign antigens that stimulate protection against shigellosis, anthrax, plague, or human papilloma virus. However, Ty21a is acid-labile and, for effective oral immunization, stomach acidity has to be either neutralized with buffer or by-passed with Ty21a in an enteric-coated capsule (ECC). Several studies have shown that efficacy is reduced when Ty21a is administered in an ECC versus as a buffered liquid formulation, the former limiting exposure to GI tract lymphoid tissues...
2016: PloS One
Yuan Yang, Nannan Quan, Jingjing Bu, Xueping Li, Ningmei Yu
BACKGROUND: High order modulation and demodulation technology can solve the frequency requirement between the wireless energy transmission and data communication. In order to achieve reliable wireless data communication based on high order modulation technology for visual prosthesis, this work proposed a Reed-Solomon (RS) error correcting code (ECC) circuit on the basis of differential amplitude and phase shift keying (DAPSK) soft demodulation. Firstly, recognizing the weakness of the traditional DAPSK soft demodulation algorithm based on division that is complex for hardware implementation, an improved phase soft demodulation algorithm for visual prosthesis to reduce the hardware complexity is put forward...
September 26, 2016: Biomedical Engineering Online
Luis Manuel Martinez-Aranda, Rodrigo Fernandez-Gonzalo
Exercise load is a key component in determining end-point adaptations to resistance exercise. Yet, there is no information regarding the use of different inertia (i.e. loads) during iso-inertial flywheel resistance exercise, a very popular high-intensity training model. Thus, this study examined power, work, force and eccentric-overload produced during flywheel resistance exercise with different inertial settings in men and women. Twenty-two women (n=11) and men (n=11) performed unilateral (in both legs) isolated concentric (CON) and coupled CON and eccentric (ECC) exercise in a flywheel knee extension device employing six inertias (0...
September 16, 2016: Journal of Strength and Conditioning Research
Mizuki Sudo, Soichi Ando, Yutaka Kano
INTRODUCTION: We recently developed an animal model to investigate the effects of eccentric contraction (ECC) and blood flow restriction (BFR) on muscle tissue at the cellular level. This study clarified the effects of repeated BFR, ECC, and BFR combined with ECC (BFR+ECC) on muscle fiber hypertrophy. METHODS: Male Wistar rats were assigned to 3 groups: BFR, ECC, and BFR+ECC. The contralateral leg in the BFR group served as a control (CONT). Muscle fiber cross sectional area (CSA) of the tibialis anterior was determined after the respective treatments for 6 weeks...
September 26, 2016: Muscle & Nerve
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