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https://www.readbyqxmd.com/read/27922068/changes-in-retinal-nerve-fiber-layer-thickness-after-multiple-injections-of-novel-vegf-decoy-receptor-conbercept-for-various-retinal-diseases
#1
Zhihua Zhang, Xiaolu Yang, Huiyi Jin, Yuan Qu, Yuan Zhang, Kun Liu, Xun Xu
Conbercept is a recombinant fusion protein with high affinity for all vascular endothelial growth factor isoforms and placental growth factor. The repeated intravitreal injection of conbercept may cause intraocular pressure (IOP) fluctuations and long-term suppression of neurotrophic cytokines, which could lead to retinal nerve fiber layer (RNFL) damage. This retrospective fellow-eye controlled study included 98 eyes of 49 patients. The changes in IOP and RNFL thickness as well as the correlation between RNFL changes and associated factors were evaluated...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27921414/the-effect-of-autologous-serum-therapy-on-disease-severity-in-patients-with-chronic-urticaria
#2
Farhad Abolnezhadian, Soheila Alyasin, Reza Amin, Maryam Babaei
Limited evidence has been obtained concerning the beneficial effects of autologous serum therapy in treatment of skin disorders particularly chronic urticaria. In the present study, we have assessed the effect of this treatment method in patients with chronic urticaria (CU). This randomized single-blind controlled trial was performed on fifty consecutive patients with chronic urticaria. The patients were randomly assigned to receive autologous serum (as the case group, n=35) or normal saline (as the control group, n=15) and treated with monthly autologous serum therapy or normal saline for 6 months...
August 2016: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/27920420/treatment-effectiveness-of-amantadine-against-dengue-virus-infection
#3
Chieh-Cheng Lin, Wen-Ching Chen
BACKGROUND About 400 million cases of dengue, a mosquito-borne disease, are reported annually, but no drug is yet available for treatment. In 1988, at Feng Lin Clinic, Taiwan, we encountered about 10,000 cases and tested various drugs before confirming an antiviral effect of amantadine against dengue virus in vitro. After we administered amantadine to patients for 1-2 days, most achieved full remission. None experienced potentially life-threatening dengue hemorrhagic fever or dengue shock syndrome. Herein, we present 34 cases from recent clinical experience that show amantadine's unusual effect against dengue virus infection...
December 5, 2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/27920351/effects-of-pediatric-anticipatory-guidance-on-mothers-of-young-children
#4
Hui-Chin Hsu, Shih-Yu Lee, Chin-Man Lai, Wan-Ling Tsai, Hsiao-Tung Chiu
Provision of anticipatory guidance to parents during well-child visits is a defining component of pediatric primary care. Using nationally representative data from the 2000 U.S. National Survey of Early Childhood Health, this study addressed the questions of whether, how, and what mothers of children below age 3 with different ethnic/racial background could benefit from anticipatory guidance. Structural equation modeling results showed that across ethnic/racial groups, guidance was directly associated with decreased maternal stress and directly and indirectly associated with effective parenting practices in child development, discipline, and safety...
December 5, 2016: Western Journal of Nursing Research
https://www.readbyqxmd.com/read/27920305/projections-of-dental-care-use-through-2026-preventive-care-to-increase-while-treatment-will-decline
#5
Chad D Meyerhoefer, Irina Panovska, Richard J Manski
This study provides a forward-thinking assessment of the factors likely to affect future trends in dental care in the United States. We developed a forecasting model based on historical data from the Medical Expenditure Panel Survey to determine how demographic trends and recent health care policies will affect dental care use in the future. Our forecasts suggest that the medical and dental insurance reforms instituted under the Affordable Care Act will increase rates of dental care use and the number of dental visits, with utilization rates reaching 47 percent in 2026 and the number of visits reaching 334 million, under optimistic assumptions about take-up of pediatric dental coverage...
December 1, 2016: Health Affairs
https://www.readbyqxmd.com/read/27920119/randomized-trial-to-reduce-emergency-visits-or-hospital-admissions-using-telephone-coaching-to-complex-patients
#6
María González-Ortega, Joan Gené-Badia, Belchin Kostov, Vicente García-Valdecasas, Carmen Pérez-Martín
BACKGROUND: Comorbidity remains a matter of international interest, given growing prevalence of chronic conditions. OBJECTIVE: To evaluate the impact that adding a telephone coaching intervention by a family physician to usual care has on reducing resource consumption and improving health status, caregiver burden and quality of life among complex chronic patients (CCP) compared with usual care. METHODS: A randomized controlled trial was conducted on a random sample of CCP from three primary care teams in Barcelona...
December 5, 2016: Family Practice
https://www.readbyqxmd.com/read/27920002/decreased-skeletal-muscle-mass-after-neoadjuvant-therapy-correlates-with-poor-prognosis-in-patients-with-esophageal-cancer
#7
Jiajia Liu, Satoru Motoyama, Yusuke Sato, Akiyuki Wakita, Yuta Kawakita, Hajime Saito, Yoshihiro Minamiya
BACKGROUND: Loss of skeletal muscle is predictive of a poor prognosis in patients with various malignant lesions. Our aim was to determine whether changes in skeletal muscle after neo-adjuvant therapy (NAT) predict prognosis in patients with esophageal squamous cell carcinoma (ESCC) undergoing esophagectomy. PATIENTS AND METHODS: The cross-sectional areas of the psoas muscles were measured on computed tomographic images collected at the initial visit, preoperatively and postoperatively in 84 patients...
December 2016: Anticancer Research
https://www.readbyqxmd.com/read/27919826/should-blood-pressure-goal-be-individualized-in-hypertensive-patients
#8
REVIEW
Alexandra Yannoutsos, Rania Kheder-Elfekih, Jean-Michel Halimi, Michel E Safar, Jacques Blacher
The aim of the present review is to consider the clinical relevance of individualized blood pressure (BP) goal under treatment in hypertensive patients according to their age, comorbidities or established cardiovascular (CV) disease. Evidence from large-scale randomized trials to support a lower BP goal, as initially recommended by guidelines in high-risk hypertensive patients, were lacking. Recently, the randomized intervention SPRINT trial studied two treatment targets for systolic BP (120mm Hg versus 140mm Hg in the intensive and standard treatment group, respectively) among high-risk hypertensive patients, without diabetes and without a history of prior stroke...
December 2, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27919398/what-is-needed-to-implement-a-web-based-audit-and-feedback-intervention-with-outreach-visits-to-improve-care-quality-a-concept-mapping-study-among-cardiac-rehabilitation-teams
#9
Mariëtte M van Engen-Verheul, Niels Peek, Joke A Haafkens, Erik Joukes, Tom Vromen, Monique W M Jaspers, Nicolette F de Keizer
INTRODUCTION: Evidence on successful quality improvement (QI) in health care requires quantitative information from randomized clinical trials (RCTs) on the effectiveness of QI interventions, but also qualitative information from professionals to understand factors influencing QI implementation. OBJECTIVE: Using a structured qualitative approach, concept mapping, this study determines factors identified by cardiac rehabilitation (CR) teams on what is needed to successfully implement a web-based audit and feedback (A&F) intervention with outreach visits to improve the quality of CR care...
January 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/27919238/an-equity-analysis-of-utilization-of-health-services-in-afghanistan-using-a-national-household-survey
#10
Christine Kim, Khwaja Mir Ahad Saeed, Ahmad Shah Salehi, Wu Zeng
BACKGROUND: Afghanistan has made great strides in the coverage of health services across the country but coverage of key indicators remains low nationally and whether the poorest households are accessing these services is not well understood. METHODS: We analyzed the Afghanistan Mortality Survey 2010 on utilization of inpatient and outpatient care, institutional delivery and antenatal care by wealth quintiles. Concentration indexes (CIs) were generated to measure the inequality of using the four services...
December 5, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27919204/use-maintenance-and-dose-effects-of-cognitive-speed-of-processing-training-in-parkinson-s-disease
#11
Elise G Valdés, Melissa L O'Connor, Ergun Y Uc, Robert A Hauser, Ross Andel, Jerri D Edwards
INTRODUCTION: Recent research indicated that cognitive speed of processing training (SPT) improved Useful Field of View (UFOV) among individuals with Parkinson's disease (PD). The effects of SPT in PD have not been further examined. The objectives of the current study were to investigate use, maintenance, and dose effects of SPT among individuals with PD. METHODS: Participants who were randomized to SPT or a delayed control group completed the UFOV at a six-month follow-up visit...
December 6, 2016: International Journal of Neuroscience
https://www.readbyqxmd.com/read/27918976/randomized-controlled-trial-of-a-family-oriented-self-management-program-to-improve-self-efficacy-glycemic-control-and-quality-of-life-among-thai-individuals-with-type-2-diabetes
#12
Nutchanath Wichit, George Mnatzaganian, Mary Courtney, Paula Schulz, Maree Johnson
AIMS: We evaluated a theoretically-derived family-oriented intervention aimed to improve self-efficacy, self-management, glycemic control and quality of life in individuals living with Type 2 diabetes in Thailand. METHODS: In a single-blinded randomized controlled trial, 140 volunteer individuals with Type 2 diabetes, recruited from a diabetes clinic in rural Thailand, were randomly allocated to intervention and control arms. Those in the intervention arm received routine care plus a family-oriented program that included education classes, group discussions, a home visit, and a telephone follow-up while the control arm only received routine care...
November 19, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/27918931/effectiveness-of-an-educational-intervention-the-encourage-autonomous-self-enrichment-program-in-patients-with-chronic-kidney-disease-a-randomized-controlled-trial
#13
Hiroko Joboshi, Michiyo Oka
BACKGROUND: Self-management is an important step toward preventing and impeding the progression of chronic kidney disease. However, patients with chronic kidney disease may have few or no subjective symptoms and therefore might consider self-management to be unnecessary. Effective support and encouragement of self-management in patients with chronic kidney disease is therefore required. OBJECTIVES: This study tested the effectiveness of the Encourage Autonomous Self-Enrichment patient education program, which supports patient autonomy and intrinsic motivations with the aim of improving self-efficacy and sustaining self-management, on perceived self-efficacy, self-management behaviors, and physiological endpoints (blood pressure and renal function parameters) in patients with chronic kidney disease...
November 22, 2016: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/27918456/examining-the-cervical-screening-behaviour-of-women-aged-50-or-above-and-its-predicting-factors-a-population-based-survey
#14
Carmen W H Chan, Kai Chow Choi, Rosa S Wong, Ka Ming Chow, Winnie K W So, Doris Y P Leung, Wendy W T Lam, William Goggins
Under-screening may increase the risk of cervical cancer in middle-aged women. This study aimed to investigate cervical cancer screening behaviour and its predictors among women aged 50 years or above. A population-based sample of 959 women was recruited by telephone from domestic households in Hong Kong, using random methods, and a structured questionnaire developed to survey participants. Multivariable logistic regressions were performed to examine the factors independently associated with cervical screening behaviour...
December 2, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27918376/reduced-length-of-stay-and-adverse-events-using-bier-block-for-forearm-fracture-reduction-in-the-pediatric-emergency-department
#15
Emmanuelle Fauteux-Lamarre, Brett Burstein, Adam Cheng, Adam Bretholz
OBJECTIVES: Forearm fractures are among the most common pediatric injuries. Procedural sedation is frequently used for analgesia during fracture reduction but requires a prolonged recovery period and can be associated with adverse events. Bier block is a safe alternative for fracture reduction analgesia. This study sought to compare Bier block and procedural sedation for forearm fracture reduction. METHODS: We performed a retrospective study of patients aged 6 to 18 years, presenting with forearm fractures requiring closed reduction from June 2012 to March 2014...
January 1, 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27918248/prevalence-of-trachoma-in-benishangul-gumuz-region-ethiopia-results-of-seven-population-based-surveys-from-the-global-trachoma-mapping-project
#16
Yilikal Adamu, Colin Macleod, Liknaw Adamu, Wirtu Fikru, Beyene Kidu, Aida Abashawl, Michael Dejene, Brian K Chu, Rebecca M Flueckiger, Rebecca Willis, Alexandre L Pavluck, Anthony W Solomon
PURPOSE: Trachoma is a major cause of blindness in Ethiopia, and targeted for elimination as a public health problem by the year 2020. Prevalence data are needed to plan interventions. We set out to estimate the prevalence of trachoma in each evaluation unit of grouped districts ("woredas") in Benishangul Gumuz region, Ethiopia. METHODS: We conducted seven cross-sectional community-based surveys, covering 20 woredas, between December 2013 and January 2014, as part of the Global Trachoma Mapping Project (GTMP)...
December 5, 2016: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/27917738/incidence-and-factors-associated-with-emergency-department-visits-for-recurrent-skin-and-soft-tissue-infections-in-patients-in-california-2005-2011
#17
L May, E Y Klein, E M Martinez, N Mojica, L G Miller
More than 2 million visits for skin and soft tissue infections (SSTIs) are seen in US emergency departments (EDs) yearly. Up to 50% of patients with SSTIs, suffer from recurrences, but associated factors remain poorly understood. We performed a retrospective study of patients with primary diagnosis of SSTI between 2005 and 2011 using California ED discharge data from the State Emergency Department Databases and State Inpatient Databases. Using a multivariable logistic regression, we examined factors associated with a repeat SSTI ED visits up to 6 months after the initial SSTI...
December 5, 2016: Epidemiology and Infection
https://www.readbyqxmd.com/read/27917447/breaking-down-barriers-enabling-care-by-parent-in-neonatal-intensive-care-units-in-china
#18
Xiao-Ying Li, Shoo Lee, Hua-Feng Yu, Xiang Y Ye, Ruth Warre, Xiang-Hong Liu, Jian-Hong Liu
BACKGROUND: Denying parents access to their infant in the Neonatal Intensive Care Unit (NICU) is a standard practice in most hospitals across China. Visitation is not usually permitted or may be strictly limited, and NICU care for most neonates is provided by health-care professionals with little participation of the parents. An exception to this rule is the level 2 "Room-In" ward in Qilu Children's Hospital, Shandong University, where parents have 24-hour access to their infants and participate in providing care...
December 5, 2016: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/27917376/evaluation-of-an-intervention-to-improve-essential-obstetric-and-newborn-care-access-and-quality-in-cotopaxi-ecuador
#19
Edward Broughton, Jorge Hermida, Kathleen Hill, Nancy Sloan, Mario Chavez, Daniel Gonzalez, Juana Maria Freire, Ximena Gudino
BACKGROUND: Despite improvements in health-care utilization, disadvantages persist among rural, less educated, and indigenous populations in Ecuador. The United States Agency for International Development-funded Cotopaxi Project created a provincial-level network of health services, including community agents to improve access, quality, and coordination of essential obstetric and newborn care. We evaluated changes in participating facilities compared to non-participating controls. METHODS: The 21 poorest parishes (third-level administrative unit) in Cotopaxi were targeted from 2010 to 2013 for a collaborative health system performance improvement...
2016: Frontiers in Public Health
https://www.readbyqxmd.com/read/27917361/il28b-genotype-is-associated-with-cirrhosis-or-transition-to-cirrhosis-in-treatment-naive-patients-with-chronic-hcv-genotype-1-infection-the-international-observational-gen-c-study
#20
Alessandra Mangia, Victor De Ledinghen, François Bailly, Javier Brahm, Jazeps Keiss, Jonas Valantinas, Nele Rasmann, Diethelm Messinger, Fernando Tatsch, Georgios Bakalos, Graham R Foster
BACKGROUND AND PURPOSE: Contradictory data exist on the association between host interleukin-28B (IL28B) rs12979860 genotype and liver fibrosis in patients with chronic hepatitis C (CHC). This large, international, observational study (NCT01675427/MV25600) investigated relationships between IL28B rs12979860 genotype and liver fibrosis stage in CHC patients. METHODS: A total of 3003 adult, treatment-naive CHC patients were enrolled into the study. Patients made one study visit to provide a blood sample for genotyping; other data were obtained from medical records...
2016: SpringerPlus
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