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Omega 3 fish oil

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https://www.readbyqxmd.com/read/27902774/intravenous-treatment-with-a-long-chain-omega-3-lipid-emulsion-provides-neuroprotection-in-a-murine-model-of-ischemic-stroke-a-pilot-study
#1
Dirk Berressem, Konrad Koch, Nicole Franke, Jochen Klein, Gunter P Eckert
Single long-chain omega-3 fatty acids (e.g. docosahexaenoic acid (DHA) or eicosapentaenoic acid (EPA)) are known for their neuroprotective properties associated with ischemic stroke. This pilot study aimed to test the effectiveness of an acute treatment with a long-chain omega-3 lipid emulsion (Omegaven 10%®, OGV) that contains fish oil (DHA 18 mg/ml; EPA 21 mg/ml) and α-tocopherol (0.2 mg/ml) in a transient middle cerebral artery occlusion (MCAO) model of ischemic stroke in mice. For this purpose, female CD-1 mice were anesthetized and subjected to 90 minutes of MCAO...
2016: PloS One
https://www.readbyqxmd.com/read/27902162/fish-oil-and-exercise-improves-older-women-s-muscle-function
#2
(no author information available yet)
Combining omega-3 supplements with a resistance exercise training programme can improve muscle function in older women, say researchers from the universities of Glasgow and Aberdeen.
November 30, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27894336/curcumin-and-long-chain-omega-3-polyunsaturated-fatty-acids-for-prevention-of-type-2-diabetes-cop-d-study-protocol-for-a-randomised-controlled-trial
#3
Rohith N Thota, Shamasunder H Acharya, Kylie A Abbott, Manohar L Garg
BACKGROUND: Lifestyle interventions, including increase in physical activity and dietary counselling, have shown the ability to prevent type 2 diabetes (T2D) in high-risk state individuals, but the prevalence is still skyrocketing in Australia, in line with global prevalence. Currently, no medicines are approved by the Therapeutic Goods Administration in Australia for the management of prediabetes. Therefore, there is a need of developing a safer, biologically efficacious and cost-effective alternative for delaying the transition of individual health state from prediabetes into T2D...
November 29, 2016: Trials
https://www.readbyqxmd.com/read/27873157/eicosapentaenoic-acid-triggers-ca-2-release-and-ca-2-influx-in-mouse-cerebral-cortex-endothelial-bend-3-cells
#4
King-Chuen Wu, Kar-Lok Wong, Mei-Ling Wang, Lian-Ru Shiao, Iat-Lon Leong, Chi-Li Gong, Ka-Shun Cheng, Paul Chan, Yuk-Man Leung
Eicosapentaenoic acid (EPA), an omega-3 fatty acid abundant in fish oil, protects endothelial cells (EC) from lipotoxicity and triggers EC NO release. The latter is related to an elevation of cytosolic Ca(2+). Although EPA has been shown to cause human EC cytosolic Ca(2+) elevation, the mechanism is unclear. Microfluorimetric imaging was used here to measure free cytosolic Ca(2+) concentration. EPA was shown to cause intracellular Ca(2+) release in mouse cerebral cortex endothelial bEND.3 cells; interestingly, the EPA-sensitive intracellular Ca(2+) pool(s) appeared to encompass and was larger than the Ca(2+) pool mobilized by sarcoplasmic-endoplasmic reticulum Ca(2+)-ATPase inhibition by cyclopiazonic acid...
November 21, 2016: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/27827947/australian-and-new-zealand-fish-oil-products-in-2016-meet-label-omega-3-claims-and-are-not-oxidized
#5
Peter D Nichols, Lalen Dogan, Andrew Sinclair
We provide new fish oil product results to assist industry in Australia and New Zealand and, ultimately, consumers in understanding the high product quality assurance protocols in place, together with the high product quality that has been determined by both industry and independent laboratories. Fish oil capsule products common to Australia and New Zealand were purchased in May 2016 in Richmond, Victoria, Australia. Products were from two groups; five standard fish oil products and five fish oil concentrates...
November 5, 2016: Nutrients
https://www.readbyqxmd.com/read/27817918/a-randomized-double-masked-placebo-controlled-clinical-trial-of-two-forms-of-omega-3-supplements-for-treating-dry-eye-disease
#6
Laura A Deinema, Algis J Vingrys, Chinn Yi Wong, David C Jackson, Holly R Chinnery, Laura E Downie
PURPOSE: To assess the efficacy of 2 forms of oral long-chain omega-3 (ω-3) essential fatty acid (EFA) supplements, phospholipid (krill oil) and triacylglyceride (fish oil), for treating dry eye disease (DED). DESIGN: Randomized, double-masked, placebo-controlled clinical trial. PARTICIPANTS: This study was conducted at a single site and involved 60 participants with mild to moderate DED who were randomized (1:1:1) to 1 of 3 groups: placebo (olive oil), krill oil, or fish oil supplements...
November 3, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27815837/fish-oil-prevents-lipopolysaccharide-induced-depressive-like-behavior-by-inhibiting-neuroinflammation
#7
Zhe Shi, Huixia Ren, Zhijian Huang, Yu Peng, Baixuan He, Xiaoli Yao, Ti-Fei Yuan, Huanxing Su
Depression is associated with somatic immune changes, and neuroinflammation is now recognized as hallmark for depressive disorders. N-3 (or omega-3) polyunsaturated fatty acids (PUFAs) are well known to suppress neuroinflammation, reduce oxidative stress, and protect neuron from injury. We pretreated animals with fish oil and induced acute depression-like behaviors with systemic lipopolysaccharide (LPS) injection. The levels of cytokines and stress hormones were determined from plasma and different brain areas...
November 4, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27789520/omega-3-polyunsaturated-fatty-acids-promote-amyloid-%C3%AE-clearance-from-the-brain-through-mediating-the-function-of-the-glymphatic-system
#8
Huixia Ren, Chuanming Luo, Yanqing Feng, Xiaoli Yao, Zhe Shi, Fengyin Liang, Jing X Kang, Jian-Bo Wan, Zhong Pei, Huanxing Su
Impairment of amyloid-β (Aβ) clearance leads to Aβ accumulation in the brain during the development of Alzheimer's disease (AD). Strategies that can restore or improve the clearance function hold great promise in delaying or preventing the onset of AD. Here, we show that n-3 polyunsaturated fatty acids (PUFAs), by use of fat-1 transgenic mice and oral administration of fish oil, significantly promote interstitial Aβ clearance from the brain and resist Aβ injury. Such beneficial effects were abolished in Aqp4-knockout mice, suggesting that the AQP4-dependent glymphatic system is actively involved in the promoting the effects of n-3 PUFAs on the clearance of extracellular Aβ...
October 7, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27766299/role-of-omega-3-fatty-acids-in-the-etiology-treatment-and-prevention-of-depression-current-status-and-future-directions
#9
Robert K McNamara
Over the past three decades a body of translational evidence has implicated dietary deficiency in long-chain omega-3 (LCn-3) fatty acids, including eicosapenaenoic acid (EPA) and docosahexaenoic acid (DHA), in the pathophysiology and etiology of major depressive disorder (MDD). Cross-national and cross-sectional data suggest that greater habitual intake of preformed EPA+DHA is associated with reduced risk for developing depressive symptoms and syndromal MDD. Erythrocyte EPA and DHA composition is highly correlated with habitual fish or fish oil intake, and case-control studies have consistently observed lower erythrocyte EPA and/or DHA levels in patients with MDD...
September 2016: Journal of Nutrition & Intermediary Metabolism
https://www.readbyqxmd.com/read/27765796/early-life-residence-fish-consumption-and-risk-of-breast-cancer
#10
Alfheidur Haraldsdottir, Laufey Steingrimsdottir, Unnur Valdimarsdottir, Thor Aspelund, Laufey Tryggvadottir, Tamara B Harris, Lenore Launer, Lorelei A Mucci, Edward L Giovannucci, Hans-Olov Adami, Vilmundur Gudnason, Johanna E Torfadottir
BACKGROUND: Little is known about fish intake throughout the life course and the risk of breast cancer. METHODS: We used data on the first residence of 9,340 women born 1908-1935 in the Reykjavik Study as well as food frequency data for different periods of life from a subgroup of the cohort entering the AGES-Reykjavik Study (n = 2,882). RESULTS: During a mean follow-up of 27.3 years, 744 women were diagnosed with breast cancer in the Reykjavik Study...
October 10, 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27754267/sy-16-1-dietary-approaches-to-prevent-and-control-elevated-blood-pressure
#11
Yongsoon Park
A healthy lifestyle is important in CVD prevention and treatment through effects on modifiable CVD risk factors, particularly blood pressure. Although the major drawback is the low level of adherence over time, appropriate lifestyle changes may safely and effectively prevent and treat hypertension. The recommended dietary approaches that have been shown to be capable of reducing blood pressure are: salt restriction, moderation of alcohol consumption, high consumption of vegetables and fruits and low-fat and other types of diet, and weight reduction...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27749350/spine-surgery-and-blood-loss-systematic-review-of-clinical-evidence
#12
Dafna Willner, Valeria Spennati, Shelly Stohl, Giulia Tosti, Simone Aloisio, Federico Bilotta
Spine surgery has been growing rapidly as a neurosurgical operation, with an increase of 220% over a 15-year period. Intraoperative blood transfusion is a major outcome determinant of spine procedures. Various approaches, including pharmacologic and nonpharmacologic therapies, have been tested to decrease both intraoperative and postoperative blood loss. The aim of this systematic review is to report clinical evidence on the relationship between intraoperative blood loss (primary outcome) and on transfusion requirements and postoperative complications (secondary outcomes) in patients undergoing spine surgery...
November 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27736913/temperature-increase-negatively-affects-the-fatty-acid-bioconversion-capacity-of-rainbow-trout-oncorhynchus-mykiss-fed-a-linseed-oil-based-diet
#13
Julie Mellery, Florian Geay, Douglas R Tocher, Patrick Kestemont, Cathy Debier, Xavier Rollin, Yvan Larondelle
Aquaculture is meant to provide fish rich in omega-3 long chain polyunsaturated fatty acids (n-3 LC-PUFA). This objective must be reached despite (1) the necessity to replace the finite and limited fish oil in feed production and (2) the increased temperature of the supply water induced by the global warming. The objective of the present paper was to determine to what extent increased water temperature influences the fatty acid bioconversion capacity of rainbow trout (Oncorhynchus mykiss) fed a plant-derived diet...
2016: PloS One
https://www.readbyqxmd.com/read/27733252/effects-of-eicosapentaenoic-acid-and-docosahexaenoic-acid-on-cardiovascular-disease-risk-factors-a-randomized-clinical-trial
#14
Ivor B Asztalos, Joi A Gleason, Sakine Sever, Reyhan Gedik, Bela F Asztalos, Katalin V Horvath, Michael L Dansinger, Stefania Lamon-Fava, Ernst J Schaefer
BACKGROUND: Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), the primary omega-3 fatty acids in fish oil, have been shown to reduce cardiovascular disease (CVD) risk. OBJECTIVE: This study aimed to examine the independent effects of EPA and DHA on lipid and apolipoprotein levels, as well as on inflammatory biomarkers of CVD risk, using doses often used in the general population. DESIGN: A blinded, randomized 6-week trial was performed in 121 healthy, normolipidemic subjects who received olive oil placebo 6g/d, EPA 600mg/d, EPA 1800mg/d, or DHA 600mg/d...
November 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27720039/risk-factors-associated-with-plasma-omega-3-fatty-acid-levels-in-patients-with-suspected-coronary-artery-disease
#15
Rahul Chaudhary, Katayoon Saadin, Kevin P Bliden, William S Harris, Bao Dinh, Tushar Sharma, Udaya S Tantry, Paul A Gurbel
INTRODUCTION: We sought to determine the associations between plasma eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) levels and various cardiovascular risk factors and with the use of fish oil supplements (FOS). PATIENTS AND METHODS: Patients with suspected coronary artery disease (CAD) undergoing cardiac catheterization (n=433) were studied. Serum fatty acid (FA) composition, the concentrations of lipids and biomarkers of oxidative stress, and dietary/lifestyle factors were measured...
October 2016: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/27719898/crystallization-and-melting-properties-of-mixtures-of-milk-fat-stearin-and-omega-3-rich-oils
#16
Bing-Zheng Li, Tuyen Truong, Bhesh Bhandari
Solid milk fat stearin (S25) can be a promising oxidation retarder due to its capacity to entrap liquid oils, especially for incorporating omega-3 (ω-3) rich oils into dairy products. Thermal properties of S25/ω-3 rich oil mixtures are necessary for such application. The effects of S25 on the crystallization and melting behaviours of ω-3 rich oils, namely fish oil (FO), linseed oil (LO) and krill oil (KO), were investigated by differential scanning calorimetry (DSC). Thermograms showed that with S25 concentration increasing, transitions of FO and LO shifted to lower and largely to higher temperatures, respectively, while crystallization temperature of KO slightly decreased...
March 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27714669/a-post-stroke-therapeutic-regimen-with-omega-3-polyunsaturated-fatty-acids-that-promotes-white-matter-integrity-and-beneficial-microglial-responses-after-cerebral-ischemia
#17
Xiaoyan Jiang, Hongjian Pu, Xiaoming Hu, Zhishuo Wei, Dandan Hong, Wenting Zhang, Yanqin Gao, Jun Chen, Yejie Shi
White matter injury induced by ischemic stroke elicits sensorimotor impairments, which can be further deteriorated by persistent proinflammatory responses. We previously reported that delayed and repeated treatments with omega-3 polyunsaturated fatty acids (n-3 PUFAs) improve spatial cognitive functions and hippocampal integrity after ischemic stroke. In the present study, we report a post-stroke n-3 PUFA therapeutic regimen that not only confers protection against neuronal loss in the gray matter but also promotes white matter integrity...
December 2016: Translational Stroke Research
https://www.readbyqxmd.com/read/27688126/brain-omega-3-polyunsaturated-fatty-acids-modulate-microglia-cell-number-and-morphology-in-response-to-intracerebroventricular-amyloid-%C3%AE-1-40-in-mice
#18
Kathryn E Hopperton, Marc-Olivier Trépanier, Vanessa Giuliano, Richard P Bazinet
BACKGROUND: Neuroinflammation is a proposed mechanism by which Alzheimer's disease (AD) pathology potentiates neuronal death and cognitive decline. Consumption of omega-3 polyunsaturated fatty acids (PUFA) is associated with a decreased risk of AD in human observational studies and exerts protective effects on cognition and pathology in animal models. These fatty acids and molecules derived from them are known to have anti-inflammatory and pro-resolving properties, presenting a potential mechanism for these protective effects...
September 29, 2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27661618/community-pharmacists-views-and-practices-regarding-natural-health-products-sold-in-community-pharmacies
#19
Ubaka Ogbogu, Candace Necyk
BACKGROUND: Reports of regulatory and evidentiary gaps have raised concerns about the marketing and use of natural health products (NHPs). The majority of NHPs offered for sale are purchased at a community pharmacy and pharmacists are "front-line" health professionals involved in the marketing and provision of NHPs. To date, the involvement of pharmacists in pharmacy care involving NHPs and the degree to which concerns over the safety, efficacy, marketing and regulation of NHPs are addressed in pharmacy care in Canada have not been studied...
2016: PloS One
https://www.readbyqxmd.com/read/27650783/progressing-insights-into-the-role-of-dietary-fats-in-the-prevention-of-cardiovascular-disease
#20
REVIEW
Peter L Zock, Wendy A M Blom, Joyce A Nettleton, Gerard Hornstra
Dietary fats have important effects on the risk of cardiovascular disease (CVD). Abundant evidence shows that partial replacement of saturated fatty acids (SAFA) with unsaturated fatty acids improves the blood lipid and lipoprotein profile and reduces the risk of coronary heart disease (CHD). Low-fat diets high in refined carbohydrates and sugar are not effective. Very long-chain polyunsaturated n-3 or omega-3 fatty acids (n-3 VLCPUFA) present in fish have multiple beneficial metabolic effects, and regular intake of fatty fish is associated with lower risks of fatal CHD and stroke...
November 2016: Current Cardiology Reports
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