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Omega 3 fish oil

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https://www.readbyqxmd.com/read/29413492/attenuation-of-obesity-and-insulin-resistance-by-fish-oil-supplementation-is-associated-with-improved-skeletal-muscle-mitochondrial-function-in-mice-fed-a-high-fat-diet
#1
Amanda R Martins, Amanda R Crisma, Laureane N Masi, Catia L Amaral, Gabriel N Marzuca-Nassr, Lucas H M Bomfim, Bruno G Teodoro, André L Queiroz, Tamires D A Serdan, Rosangela P Torres, Jorge Mancini-Filho, Alice C Rodrigues, Tatiana C Alba-Loureiro, Tania C Pithon-Curi, Renata Gorjao, Leonardo R Silveira, Rui Curi, Philip Newsholme, Sandro M Hirabara
Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been reported to improve insulin sensitivity and glucose homeostasis in animal models of insulin resistance, but the involved mechanisms still remain unresolved. In this study, we evaluated the effects of fish oil (FO), a source of n-3 PUFAs, on obesity, insulin resistance and muscle mitochondrial function in mice fed a high-fat diet (HFD). C57Bl/6 male mice, 8 weeks old, were divided into four groups: control diet (C), high-fat diet (H), C+FO (CFO) and H+FO (HFO)...
December 11, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29394279/characterisation-of-the-vasodilation-effects-of-dha-and-epa-n-3-pufas-fish-oils-in-rat-aorta-and-mesenteric-resistance-arteries
#2
Roshan Limbu, Graeme S Cottrell, Alister J McNeish
BACKGROUND AND PURPOSE: Increasing evidence suggests that the omega-3 polyunsaturated acids (n-3 PUFA), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), are beneficial to cardiovascular health, promoting relaxation of vascular smooth muscle cells and vasodilation. Numerous studies have attempted to study these responses, but to date there has not been a systematic characterisation of both DHA and EPA mediated vasodilation in conduit and resistance arteries. Therefore, we aimed to fully characterise the n-3 PUFA-induced vasodilation pathways in rat aorta and mesenteric artery...
2018: PloS One
https://www.readbyqxmd.com/read/29391641/preparation-of-omega-3-rich-oral-supplement-using-dairy-and-non-dairy-based-ingredients
#3
Gunvantsinh Rathod, Narsaiah Kairam
Fish oil is a rich source of omega 3 fatty acids, an essential fatty acid, vital for the functioning of the human body. But the undesirable flavour is an inherent limitation of fish oil which reduces its acceptability. Masking its fish flavour can increase acceptability of fish oil. The present study was focused on double encapsulation of fish oil to mask its distinct flavour. Fish oil was emulsified using soya lecithin where emulsifier to fat ratio was kept 1:4. The emulsion droplets were in the size range of 172...
February 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29389608/nutrigenomic-studies-on-hilsa-to-evaluate-flesh-quality-attributes-and-genes-associated-with-fatty-acid-metabolism-from-the-rivers-hooghly-and-padma
#4
Satabdi Ganguly, Arabinda Mahanty, Tandrima Mitra, Sasmita Mohanty, Basanta Kumar Das, Bimal Prasanna Mohanty
The Indian shad hilsa (Tenualosa ilisha), a commercially important food fish rich in oils, enjoys high consumer preference in the South Asian countries owing to its unique flavour and culinary properties. The present study was undertaken with the primary objective of determining the flesh quality attributes of hilsa in terms of nutritive value (gross chemical composition, amino acid, fatty acid and mineral composition), pH, water holding capacity (WHC) and expression of genes associated with fatty acid metabolism and flesh quality...
January 2018: Food Research International
https://www.readbyqxmd.com/read/29385062/a-randomized-double-blinded-placebo-controlled-trial-investigating-the-effect-of-fish-oil-supplementation-on-gene-expression-related-to-insulin-action-blood-lipids-and-inflammation-in-gestational-diabetes-mellitus-fish-oil-supplementation-and-gestational-diabetes
#5
Mehri Jamilian, Mansooreh Samimi, Naghmeh Mirhosseini, Faraneh Afshar Ebrahimi, Esmat Aghadavod, Mohsen Taghizadeh, Zatollah Asemi
Gestational diabetes mellitus (GDM) is a common complication of pregnancy, and it is mostly associated with postpartum diabetes, insulin resistance, and dyslipidemia. Fish oil (omega-3) supplementation has been shown to reduce the risk of different chronic diseases such as cardiovascular disease, type 2 diabetes, and cancers, though the evidence of its impact on gestational diabetes is scarce. Our goal in this study was to determine the effect of fish oil administration on gene expression related to insulin action, blood lipids, and inflammation in women with GDM...
January 31, 2018: Nutrients
https://www.readbyqxmd.com/read/29382165/lipase-produced-hydroxytyrosyl-eicosapentaenoate-is-an-excellent-antioxidant-for-the-stabilization-of-omega-3-bulk-oils-emulsions-and-microcapsules
#6
Taiwo Olusesan Akanbi, Colin James Barrow
In this study, several lipophilic hydroxytyrosyl esters were prepared enzymatically using immobilized lipase from Candida antarctica B. Oxidation tests showed that these conjugates are excellent antioxidants in lipid-based matrices, with hydroxytyrosyl eicosapentaenoate showing the highest antioxidant activity. Hydroxytyrosyl eicosapentaenoate effectively stabilized bulk fish oil, fish-oil-in-water emulsions and microencapsulated fish oil. The stabilizing effect of this antioxidant may either be because it orients itself with the omega-3 fatty acids in the oil, thereby protecting them against oxidation, or because this unstable fatty acid can preferentially oxidise, thus providing an additional mechanism of antioxidant protection...
January 29, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29378575/effects-of-omegaven%C3%A2-epa-dha-and-oxaliplatin-on-oesophageal-adenocarcinoma-cell-lines-growth-cytokine-and-cell-signal-biomarkers-expression
#7
Amar M Eltweri, Lynne M Howells, Anne L Thomas, Ashley R Dennison, David J Bowrey
BACKGROUND: There is limited evidence assessing the effects of omega-3 polyunsaturated fatty acids (PUFAs) on oesophageal adenocarcinoma, both in vitro and in vivo. We evaluated the effects of the omega-3 PUFA and oxaliplatin on OE33 and OE19 cells. METHOD: The two oesophageal cells were treated with Omegaven® (fish oil emulsion), EPA, DHA and oxaliplatin and incubated for up to 144 h. RESULTS: The following inhibitory effects were observed on OE33 cells: EPA reduced cell growth by 39% (p = 0...
January 30, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29359480/the-effects-of-fish-oil-on-gene-expression-in-patients-with-polycystic-ovary-syndrome
#8
Elham Rahmani, Mehri Jamilian, Bahareh Dadpour, Zahra Nezami, Zahra Vahedpoor, Samaneh Mahmoodi, Esmat Aghadavod, Mohsen Taghizadeh, Abolfazl Beiki Hassan, Zatollah Asemi
BACKGROUND: This study was conducted to determine the effects of fish oil administration on gene expression related to insulin, lipid and inflammation in women with polycystic ovary syndrome (PCOS). MATERIALS AND METHODS: This randomized, double-blind, placebo-controlled trial was conducted among 40 subjects with PCOS, aged 18-40 years old. Subjects were randomly allocated into two groups to take either 1000 mg omega-3 fatty acids from fish oil (n=20) or placebo (n=20) twice a day for 12 weeks...
January 23, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29340233/crustacean-amphipods-from-marsh-ponds-a-nutritious-feed-resource-with-potential-for-application-in-integrated-multi-trophic-aquaculture
#9
Pablo Jiménez-Prada, Ismael Hachero-Cruzado, Inmaculada Giráldez, Catalina Fernández-Diaz, César Vilas, José Pedro Cañavate, José Manuel Guerra-García
Coastal protection, nutrient cycling, erosion control, water purification, and carbon sequestration are ecosystem services provided by salt marshes. Additionally, salt ponds offer coastal breeding and a nursery habitat for fishes and they provide abundant invertebrates, such as amphipods, which are potentially useful as a resource in aquaculture. Fishmeal and fish oil are necessary food resources to support aquaculture of carnivorous species due to their omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFA)...
2018: PeerJ
https://www.readbyqxmd.com/read/29321047/effects-of-concentrated-long-chain-omega-3-polyunsaturated-fatty-acid-supplementation-before-radical-prostatectomy-on-prostate-cancer-proliferation-inflammation-and-quality-of-life-study-protocol-for-a-phase-iib-randomized-double-blind-placebo-controlled-trial
#10
Marie-Hélène Guertin, Karine Robitaille, Jean-François Pelletier, Thierry Duchesne, Pierre Julien, Josée Savard, Isabelle Bairati, Vincent Fradet
BACKGROUND: Prostate cancer is the most commonly diagnosed cancer in north-American men. Few dietary or lifestyle interventions have been tested to prevent prostate cancer progression. Omega-3 fatty acid supplementation represents a promising intervention for prostate cancer patients. The aim of the study is to evaluate the effects of long-chain omega-3 polyunsaturated fatty acids (LCn3), more precisely eicosapentaenoic acid monoacylglyceride (MAG-EPA) supplementation, on prostate cancer proliferation, inflammation mediators and quality of life among men who will undergo radical prostatectomy...
January 10, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29306078/effect-of-fish-oil-on-agonist-induced-receptor-internalization-of-the-pg-f2%C3%AE-receptor-and-cell-signaling-in-bovine-luteal-cells-in%C3%A2-vitro
#11
M R Plewes, P D Burns
Many receptors span the plasma membrane allowing for signal transduction, converting extracellular signals into intracellular signals. Following ligand-induced activation, membrane-bound receptors are taken into endocytic vesicles, where they are targeted for degradation or recycled back to the plasma membrane. The objectives of the present study were to determine the influence of fish oil on (1) PGF2α-induced receptor internalization and trafficking of the PGF2α (FP) receptor, (2) cytoskeletal structural integrity, and (3) PGF2α-induced mitogen-activated protein kinase (MAPK) signaling in bovine luteal cells...
December 12, 2017: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/29305832/all-n-3-pufa-are-not-the-same-md-simulations-reveal-differences-in-membrane-organization-for-epa-dha-and-dpa
#12
Xiaoling Leng, Jacob J Kinnun, Andres T Cavazos, Samuel W Canner, Saame Raza Shaikh, Scott E Feller, Stephen R Wassall
Eicosapentaenoic (EPA, 20:5), docosahexaenoic (DHA, 22:6) and docosapentaenoic (DPA, 22:5) acids are omega-3 polyunsaturated fatty acids (n-3 PUFA) obtained from dietary consumption of fish oils that potentially alleviate the symptoms of a range of chronic diseases. We focus here on the plasma membrane as a site of action and investigate how they affect molecular organization when taken up into a phospholipid. All atom MD simulations were performed to compare 1-stearoyl-2-eicosapentaenoylphosphatylcholine (EPA-PC, 18:0-20:5PC), 1-stearoyl-2-docosahexaenoylphosphatylcholine (DHA-PC, 18:0-22:6PC), 1-stearoyl-2-docosapentaenoylphosphatylcholine (DPA-PC, 18:0-22:5PC) and, as a monounsaturated control, 1-stearoyl-2-oleoylphosphatidylcholine (OA-PC, 18:0-18:1PC) bilayers...
January 3, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29286866/omega-3-fatty-acid-deficiency-impairs-frontostriatal-recruitment-following-repeated-amphetamine-treatment-in-rats-a-7-tesla-in-vivo-phmri-study
#13
Robert K McNamara, Jennifer D Schurdak, Ruth H Asch, Diana M Lindquist
Although attention deficit hyperactivity disorder is associated with deficits in docosahexaenoic acid (DHA), an omega-3 fatty acid implicated in dopamine and glutamate synaptic plasticity, its role in neuroplastic brain changes that occur following repeated amphetamine (AMPH) treatment are not known. This study used pharmacological magnetic resonance imaging to investigate the impact of repeated AMPH exposure and alterations in brain DHA levels on AMPH-induced brain activation patterns. Male rats were fed a diet with no n-3 fatty acids (Deficient, DEF, n = 20), a diet fortified with preformed DHA (fish oil, FO, n = 20), or a control diet fortified with alpha-linolenic acid (n = 20) from P21 to P90...
December 29, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29282085/effects-of-12-week-supplementation-of-marine-omega-3-pufa-based-formulation-omega3q10-in-older-adults-with-prehypertension-and-or-elevated-blood-cholesterol
#14
Tian Shen, Guoqiang Xing, Jingfen Zhu, Shuxian Zhang, Yong Cai, Donghua Li, Gang Xu, Evan Xing, Jianyu Rao, Rong Shi
BACKGROUNDS: To study the effects of supplementation of a marine omega-3 poly-unsaturated fatty acids (n3-PUFA) formulation (Omega3Q10) in older adults with hypertension and/or hypercholesterolemia. METHODS: A total of 97 people were enrolled to receive 12-week supplementation of either Omega3Q10 (n = 48) or soybean oil (n = 49). Total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), and hypertension-related symptoms were determined before and after the supplementation...
December 27, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29280361/cardiovascular-disease-and-omega-3s-prescription-products-and-fish-oil-dietary-supplements-are-not-the-same
#15
REVIEW
Adina S Gutstein, Tina Copple
BACKGROUND AND PURPOSE: Despite achievement of optimal low-density lipoprotein cholesterol (LDL-C) control with statin therapy, patients with elevated triglycerides (TGs) and residual cardiovascular risk are commonly encountered in clinical practice. METHODS: We present information from completed and ongoing clinical trials examining Rx omega-3s for TG-lowering and omega-3 dietary supplements to highlight important differences affecting patient management for nurse practitioners...
December 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/29259181/comparison-of-the-effect-of-omega-3-supplements-and-fresh-fish-on-lipid-profile-a-randomized-open-labeled-trial
#16
Mohammad Javad Zibaeenezhad, Maryam Ghavipisheh, Armin Attar, Amir Aslani
BACKGROUND: Dietary fish is a rich source of Omega-3 poly-unsaturated fatty acids (PUFAs). These compounds may have protective effect against cardiovascular events possibly by modifying lipid profiles. Consequently, fish oil supplements are produced commercially to complement low fish intake. It is not clear if both interventions have similar effects. The aim of this trial was to compare the anti-hyperlipidemic effect of omega3 fatty acid supplements with fresh fish. METHOD: A total of 106 patients with hyperlipidemia were randomized...
December 19, 2017: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29218228/similar-adverse-events-from-two-disparate-agents-implicate-lipid-inflammatory-mediators-for-a-role-in-anxiety-states
#17
Gordon C McCarter, Lauren B Blanchard
We recently reported a case in which a 54-year-old male experienced maintenance insomnia, generalized anxiety and panic symptoms associated with consumption of a fish oil supplement enriched in eicosapentaenoic acid (EPA). We report here that the same patient has experienced identical but more severe symptoms in response to the use of the leukotriene receptor antagonist montelukast, in accordance with other cases reported to the Food and Drug Administration. Since omega-3 fatty acids like EPA are precursors for the biosynthesis of eicosanoids including leukotrienes, a common factor to these psychiatric adverse events may be perturbations in this highly complex system of lipid inflammatory mediators...
November 2017: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/29216635/deficits-in-docosahexaenoic-acid-accrual-during-adolescence-reduce-rat-forebrain-white-matter-microstructural-integrity-an-in-vivo-diffusion-tensor-imaging-study
#18
Robert K McNamara, Jennifer D Schurdak, Ruth H Asch, Bart D Peters, Diana M Lindquist
Neuropsychiatric disorders that frequently initially emerge during adolescence are associated with deficits in the omega-3 (n-3) fatty acid docosahexaenoic acid (DHA), elevated proinflammatory signaling, and regional reductions in white matter integrity (WMI). This study determined the effects of altering brain DHA accrual during adolescence on WMI in the rat brain by diffusion tensor imaging (DTI), and investigated the potential mediating role of proinflammatory signaling. During periadolescent development, male rats were fed a diet deficient in n-3 fatty acids (DEF, n = 20), a fish oil-fortified diet containing preformed DHA (FO, n = 20), or a control diet (CON, n = 20)...
December 8, 2017: Developmental Neuroscience
https://www.readbyqxmd.com/read/29215971/a-mediterranean-style-dietary-intervention-supplemented-with-fish-oil-improves-diet-quality-and-mental-health-in-people-with-depression-a-randomized-controlled-trial-helfimed
#19
Natalie Parletta, Dorota Zarnowiecki, Jihyun Cho, Amy Wilson, Svetlana Bogomolova, Anthony Villani, Catherine Itsiopoulos, Theo Niyonsenga, Sarah Blunden, Barbara Meyer, Leonie Segal, Bernhard T Baune, Kerin O'Dea
OBJECTIVES: We investigated whether a Mediterranean-style diet (MedDiet) supplemented with fish oil can improve mental health in adults suffering depression. METHODS: Adults with self-reported depression were randomized to receive fortnightly food hampers and MedDiet cooking workshops for 3 months and fish oil supplements for 6 months, or attend social groups fortnightly for 3 months. Assessments at baseline, 3 and 6 months included mental health, quality of life (QoL) and dietary questionnaires, and blood samples for erythrocyte fatty acid analysis...
December 7, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29209514/fish-oil-supplementation-in-chronic-obstructive-pulmonary-disease-feasibility-of-conducting-a-randomised-controlled-trial
#20
Ashley S Fulton, Alison M Coates, Marie T Williams, Peter R C Howe, Manohar L Garg, Lisa G Wood, Peter Frith, Alison M Hill
Background: Long-chain omega-3 polyunsaturated fatty acids (LCn-3PUFAs) may act as an effective adjunct therapy for chronic obstructive pulmonary disease (COPD), a condition characterised by persistent airflow limitation and inflammation. However, the nature of this illness presents challenges for evaluating potential benefits. The aim of this study was to determine the feasibility of undertaking a randomised controlled trial of LCn-3PUFA supplementation in adults with COPD. Methods: A 16-week parallel, double-blind, randomised, placebo-controlled dietary supplementation trial was conducted...
2017: Pilot and Feasibility Studies
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