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Stephanie Natale, John Bradley, William Huy Nguyen, Tri Tran, Pamela Ny, Kirsten La, Eva Vivian, Jennifer Le
BACKGROUND: Limited data exist for appropriate drug dosing in obese children. This comprehensive review summarizes pharmacokinetic alterations that occur with age and obesity, and these effects on antimicrobial dosing. A thorough comparison of different measures of body weight and specific antimicrobial agents, including cefazolin, cefepime, ceftazidime, daptomycin, doripenem, gentamicin, linezolid, meropenem, piperacill-tazobactam, tobramycin, vancomycin, and voriconazole, are presented...
January 12, 2017: Pharmacotherapy
Gulseren Aktas, Sengul Derbentli
OBJECTIVES: Combination therapies have a distinct advantage over monotherapies in terms of their broad spectrum, synergistic effect and prevention of the emergence of drug resistance. In the present study, the in vitro antibacterial activity of daptomycin combinations with linezolid and dalbavancin, and dalbavancin with linezolid were evaluated against 30 clinical MRSA strains. METHODS: The MICs of all antibiotics were determined using microbroth dilution as described by the CLSI...
September 28, 2016: Journal of Antimicrobial Chemotherapy
Xu Wang, Milya Davlieva, Jinnethe Reyes, Diana Panesso, Cesar A Arias, Yousif Shamoo
Substitutions in the LiaFSR membrane stress pathway are frequently associated with emergence of antimicrobial peptide resistance in both Enterococcus faecalis and Enterococcus faecium Cyclic di-AMP (c-di-AMP) is an important signal molecule that affects many aspects of bacterial physiology including stress response. We have identified previously a mutation in a gene (designated yybT) in E. faecalis that was associated with development of daptomycin resistance resulting in a change at position 440 in the predicted protein (yybT(I440S))...
January 9, 2017: Antimicrobial Agents and Chemotherapy
Rachael McCool, Ian M Gould, Jacqui Eales, Teresa Barata, Mick Arber, Kelly Fleetwood, Julie Glanville, Teresa L Kauf
BACKGROUND: Tedizolid, the active moiety of tedizolid phosphate, is approved in the United States, the European Union, Canada and a number of other countries for the treatment of acute bacterial skin and skin structure infections (ABSSSI) caused by certain susceptible bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). This network meta-analysis (NMA) evaluates the comparative effectiveness of tedizolid and other antibacterials indicated for the treatment of ABSSSI caused by MRSA...
January 7, 2017: BMC Infectious Diseases
Erin S Honsa, Vaughn S Cooper, Mohammed N Mhaissen, Matthew Frank, Jessica Shaker, Amy Iverson, Jeffrey Rubnitz, Randall T Hayden, Richard E Lee, Charles O Rock, Elaine I Tuomanen, Joshua Wolf, Jason W Rosch
: Serious bacterial infections in immunocompromised patients require highly effective antibacterial therapy for cure, and thus, this setting may reveal novel mechanisms by which bacteria circumvent antibiotics in the absence of immune pressure. Here, an infant with leukemia developed vancomycin-resistant Enterococcus faecium (VRE) bacteremia that persisted for 26 days despite appropriate antibiotic therapy. Sequencing of 22 consecutive VRE isolates identified the emergence of a single missense mutation (L152F) in relA, which constitutively activated the stringent response, resulting in elevated baseline levels of the alarmone guanosine tetraphosphate (ppGpp)...
January 3, 2017: MBio
Du'an Lin, Hiu Yung Lam, Wenbo Han, Nicole Cotroneo, Bhaumik A Pandya, Xuechen Li
Daptomycin is a highly effective lipopeptide antibiotic against Gram-positive pathogens. The presence of (2S, 3R) 3-methyl glutamic acid (mGlu) in daptomycin has been found to be important to the antibacterial activity. However the role of (2S, 3R) mGlu is yet to be revealed. Herein, we reported the syntheses of three daptomycin analogues with (2S, 3R) mGlu substituted by (2S, 3R) methyl glutamine (mGln), dimethyl glutamic acid and (2S, 3R) ethyl glutamic acid (eGlu), respectively, and their antibacterial activities...
December 18, 2016: Bioorganic & Medicinal Chemistry Letters
Nicholas S Britt, Emily M Potter, Nimish Patel, Molly E Steed
BACKGROUND: Vancomycin-resistant Enterococcus bloodstream infections (VRE-BSI) are associated with significant mortality. Daptomycin exhibits concentration-dependent activity versus VRE in vitro, yet the clinical impact of higher-dose strategies remains unclear. METHODS: We performed a national retrospective cohort study of hospitalized Veterans Affairs patients treated with standard- (6 mg/kg total body weight), medium- (8 mg/kg total body), and high-dose (≥ 10 mg/kg total body weight) daptomycin for VRE-BSI...
December 22, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Hideo Kato, Mao Hagihara, Naoya Nishiyama, Yusuke Koizumi, Yuka Yamagishi, Katsuhiko Matsuura, Hiroshige Mikamo
This study was to evaluate the loading does of daptomycin, a novel lipopeptide antibacterial active against Gram-positive pathogens, on clinical efficiency. We divided patients received daptomycin therapy into 2 groups. One of two groups comprised patients received the loading dose of daptomycin on day 1 (group 1) and the other group received normal dosage (4-6 mg/kg/day) (group 2). Inflammatory markers were assessed at least 3 days before daptomycin therapy started as their baseline, and 2 weeks from daptomycin therapy started for the evaluation of clinical efficacy...
December 20, 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
Yuxiang Dong, Tamara Lushnikova, Radha M Golla, Xiaofang Wang, Guangshun Wang
Antimicrobial peptides (AMPs) are important templates for developing new antimicrobial agents. Previously, we developed a database filtering technology that enabled us to design a potent anti-Staphylococcal peptide DFTamP1. Using this same design approach, we now report the discovery of a new class of bis-indole diimidazolines as AMP small molecule mimics. The best compound killed multiple S. aureus clinical strains in both planktonic and biofilm forms. The compound appeared to target bacterial membranes with antimicrobial activity and membrane permeation ability similar to daptomycin...
November 30, 2016: Bioorganic & Medicinal Chemistry
Jun Hirai, Mao Hagihara, Shusaku Haranaga, Takeshi Kinjo, Hiroe Hashioka, Hideo Kato, Daisuke Sakanashi, Yuka Yamagishi, Hiroshige Mikamo, Jiro Fujita
Here we report six cases of daptomycin (DAP)-induced eosinophilic pneumonia (DIEP) encountered at two medical centers and present a review of 43 DIEP patients from 26 studies to compare the clinical characteristics and radiographic findings of acute and chronic eosinophilic pneumonia (AEP; CEP). Four of the six patients did not exhibit respiratory symptoms, and one patient with only fever was misdiagnosed with DAP-induced fever. According to our literature review and the present findings, male sex and old age were dominant risk factors for DIEP...
December 18, 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
Priyasha Uppal, Kerry L LaPlante, Melissa M Gaitanis, Matthew D Jankowich, Kristina E Ward
PURPOSE: Eosinophilic pneumonia comprises a group of lung diseases in which eosinophils appear in increased numbers in the lungs and sometimes in the bloodstream. Several case reports link daptomycin use to this phenomenon. SUMMARY: We performed a systematic literature review to identify cases of eosinophilic pneumonia associated with daptomycin use. Relevant studies were identified by searching Pubmed/Medline, EMBASE, Google Scholar, Cochrane Database of Systematic Reviews, and Clin-Alert from inception to May 2016, and manual searches of reference lists...
2016: Antimicrobial Resistance and Infection Control
Chia-Yi Cheng, Chun-Ping Chang, Tsai-Ling Yang Lauderdale, Guann-Yi Yu, Jinq-Chyi Lee, Yi-Wun Jhang, Chien-Huang Wu, Yi-Yu Ke, Amit A Sadani, Ching-Fang Yeh, I-Wen Huang, Yi-Ping Kuo, De-Jiun Tsai, Teng-Kuang Yeh, Chen-Tso Tseng, Jen-Shin Song, Yu-Wei Liu, Lun K Tsou, Kak-Shan Shia
Series of N-substituted carbazole analogues bearing an indole ring were synthesized as anti-methicillin-resistant Staphylococcus aureus (MRSA) agents from a molecular hybridization approach. The representative compound 19 showed an MIC = 1 μg/mL against a panel of MRSA clinical isolates as it possessed comparable in vitro activities to that of vancomycin. Moreover, compound 19 also exhibited MIC = 1 μg/mL activities against a recent identified Z172 MRSA strain (vancomycin-intermediate and daptomycin-nonsusceptible phenotype) and the vancomycin-resistant Enterococcus faecalis (VRE) strain...
December 8, 2016: ACS Medicinal Chemistry Letters
Michael A Pfaller, Paul R Rhomberg, Michael D Huband, Robert K Flamm
Omadacycline is a new broad spectrum aminomethylcycline in late stage clinical development for acute bacterial skin and skin structure infections (ABSSSI) and community-acquired pneumonia (CABP) as a once-daily formulation taken orally or intravenously. In this study, omadacycline and comparator agents were tested against 502 isolates of Staphylococcus aureus selected from a 2014 global surveillance program and compared to the results for 7,740 isolates from a 2010 surveillance program. For the 2014 isolates, testing was completed on 252 isolates from Europe (EU) and 250 isolates from North America (NA)...
December 19, 2016: Antimicrobial Agents and Chemotherapy
M M Suyemoto, Hjb Barnes, L B Borst
Pathogenic strains of Enterococcus cecorum (EC) expressing multidrug resistance have emerged. In National Antimicrobial Resistance Monitoring System (NARMS) data, EC is rarely recovered from chickens. Two NARMS methodologies (FDA, USDA) were compared with standard culture (SC) techniques for recovery of EC. NARMS methods failed to detect EC in 58 cecal samples, 20 chicken breast or 6 whole broiler samples. EC was recovered from 1 of 38 (2.6%) and 2 of 38 (5.2%) pre-harvest spinal lesions (USDA and FDA method respectively)...
December 17, 2016: Letters in Applied Microbiology
Tyler Liebenstein, Lucas T Schulz, Chris Viesselmann, Emma Bingen, Jackson Musuuza, Nasia Safdar, Warren E Rose
STUDY OBJECTIVE: As patients with abdominal solid organ transplants (SOT) are at increased risk of polymicrobial intraabdominal infections (IAIs) following transplantation, the objective of this study was to compare the effectiveness and adverse event profile of tigecycline with those of other broad-spectrum therapies for polymicrobial IAIs in this population. DESIGN: Retrospective cohort study. SETTING: Large academic medical center with multiple outpatient clinics...
December 16, 2016: Pharmacotherapy
Rodrigo E Mendes, Mariana Castanheira, David J Farrell, Robert K Flamm, Helio S Sader, Ronald N Jones
The aim of this study was to evaluate the prevalence of resistance to erythromycin alone (M) and to erythromycin and clindamycin (cMLSB) as well as multidrug resistance (MDR) phenotypes (resistance to at least three classes of drugs) among clinical enterococci from European countries and adjacent geographic regions. The in vitro activity of oritavancin against these isolates was also evaluated. A total of 2569 streptococci collected from 12 European countries as well as Russia, Turkey and Israel were included...
November 2, 2016: Journal of Global Antimicrobial Resistance
Guillaume Ghislain Aubin, Colin Deschanvres, David Boutoille, Pierre Abgueguen, Stéphane Corvec, Jocelyne Caillon, Didier Lepelletier, Frédéric Moal, Dominique Navas
No abstract text is available yet for this article.
January 2017: Future Microbiology
Chuda Raj Lohani, Jacob Soley, Braden Kralt, Michael Palmer, Scott D Taylor
α-Azido esters, when treated with dithiothreitol (DTT)/diisopropylethylamine (DIPEA), undergo both azido group reduction to give α-amino esters and C-O bond cleavage to give triazoles. The extent of triazole formation depends upon leaving group ability. Some C-O bond cleavage via triazole formation was also found to occur when a resin-bound peptide, which contained a terminal α-azido ester group, was treated with DTT/DIPEA. C-O bond cleavage also took place when this peptide was treated with PPh3, PBu3, or PMe3; however, in these cases, C-O bond cleavage occurred via either triazole formation and/or hydrolysis of the ester bond in the iminophosphorane intermediate to give betaines...
December 2, 2016: Journal of Organic Chemistry
Daniel Echeverría-Esnal, Santiago Grau, Juan Pablo Horcajada
No abstract text is available yet for this article.
January 2017: Future Microbiology
Dan Zhang, Wen Ma, Yu He, Gu He, Peng Zhang, Hongxia Zhu, Ningzhi Xu, Shufang Liang
The data presented in this article are related to the research article entitled "Antibacterial mechanism of daptomycin antibiotic against Staphylococcus aureus based on a quantitative bacterial proteome analysis" (Ma et al., 2016) [1]. Nucleoside diphosphate kinase (NDK) and 5'-nucleotidase (NT5) are two proteins related to bacterial growth. Here, a bioinformatics analysis was presented to explore NDK and NT5-invovled in the interacting protein network and purine metabolism.
December 2016: Data in Brief
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