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https://www.readbyqxmd.com/read/28228292/a-fresh-look-at-bioresorbable-scaffold-technology-intuition-pumps
#1
EDITORIAL
Sundeep Mishra
Bioresorbable scaffolds (BRS) are a new enticing treatment option in coronary interventions. Absorb BVS™ Is the most widely used and researched polymer based BRS, eluting everolimus. However currently it has several technical limitations; low radial support, larger strut size, poor visualization, poor deliverability and complex implantation technique. Magnesium based BRS are an alternate but they are also limited not only by lower radial support and poor visualization but also earlier bio-absorption. Material processing: blow-molding, annealing, polymer orientation, change in composition and use of higher molecular weight polymer, as well new polymers like tyrosine or salicyclate analogs and even hybrid (polymer and metallic) combined with intelligent cell design has led to evolution of BRS technology...
January 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28218604/everolimus-eluting-bioresorbable-vascular-scaffold-for-treatment-of-complex-chronic-total-occlusions
#2
Jiang Ming Fam, Soledad Ojeda, Roberto Garbo, Azeem Latib, Alessio La Manna, Beatriz Vaquerizo, Marouane Boukhris, Georgios J Vlachojannis, Robert Jan van Geuns, Babu Ezhumalai, Hiroyoshi Kawamoto, Jors van der Sijde, Cordula Felix, Manuel Pan, Roberta Serdoz, Giacomo Giovanni Boccuzzi, Marcella De Paolis, Gennaro Sardella, Corrado Tamburino, Pieter C Smits, Carlo Di Mario, Ashok Seth, Antonio Serra, Antonio Colombo, Patrick Serruys, Alfredo R Galassi, Felix Zijlstra, Nicolas M van Mieghem, Roberto Diletti
AIMS: Bioresorbable vascular scaffolds (BVS) represent a novel therapeutic option for the treatment of coronary artery diseases. The objective of this study is to evaluate the feasibility of BVS implantation in complex chronic total occlusions (CTO). METHODS AND RESULTS: The present report is a multi-centre registry evaluating results after BVS deployment in challenging CTO lesions defined as J-CTO score≥2 (difficult or very difficult). A total of 105 patients were included in the present analysis...
February 21, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28185417/left-main-coronary-angioplasty-of-a-9-year-old-child-with-bioresorable-vascular-scaffold
#3
Hasmukh Ravat, Swati Garekar, Vishal Changela
Familial hypercholesterolemia is an autosomal dominant disorder due to mutations in the low-density lipoprotein receptor gene, characterized by skin and tendon xanthomas, xanthelasmas, and increased risk of premature coronary artery disease. Here, we report a case of 9-year-old girl who presented with angina and dyspnoea on exertion with xanthomas and an elevated serum cholesterol and triglyceride. She had severe stenosis of the left main coronary artery (LMCA) requiring angioplasty and placement of Bioresorbable vascular scaffold (BVS)...
February 10, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28177367/using-markers-with-large-effect-in-genetic-and-genomic-predictions
#4
M S Lopes, H Bovenhuis, M van Son, Ø Nordbø, E H Grindflek, E F Knol, J W M Bastiaansen
The first attempts of applying marker-assisted selection (MAS) in animal breeding were not very successful because the identification of markers closely linked to QTL using low-density microsatellite panels was difficult. More recently, the use of high-density SNP panels in genome-wide association studies (GWAS) have increased the power and precision of identifying markers linked to QTL, which offer new possibilities for MAS. However, when GWAS started to be performed, the focus of many breeders had already shifted from the use of MAS to the application of genomic selection (using all available markers without any preselection of markers linked to QTL)...
January 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28164433/coronary-artery-aneurysm-after-implantation-of-a-bioresorbable-vascular-scaffold-case-report-and-literature-review
#5
Su-Kiat Chua, Jun-Jack Cheng
A 55-year-old man underwent successful percutaneous coronary intervention for the middle left circumflex artery with a 3.5 × 28-mm bioresorbable vascular scaffold (BVS). At 18 months, follow-up coronary angiography showed ectatic change with aneurysm formation over the BVS. Optical coherence tomography revealed absence of strut continuity at the aneurysm site, in the middle of the BVS. A literature review identified nine patients with intrascaffold aneurysm, including the present patient, which developed 6-32 months after BVS implantation...
February 6, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28145045/intraluminal-bioresorbable-vascular-scaffold-dismantling-with-aneurysm-formation-leading-to-very-late-thrombosis
#6
Amisha Patel, Tamim Nazif, Gregg W Stone, Ziad A Ali
Coronary artery aneurysm formation has been described in patients after the placement of first-generation drug-eluting stents (DES), but is less common with newer generation metallic stents. In contrast, coronary artery aneurysm formation may be more common with the use of bioresorbable vascular scaffolds (BVS) due to the frequent formation of evaginations in the arterial wall seen with BVS. In this article, we describe a unique case of BVS dismantling and thrombus formation leading to an acute coronary syndrome thirty-two months after initial BVS placement...
February 1, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28135996/mental-health-and-public-policies-implemented-in-the-northeast-of-brazil-a-systematic-review-with-meta-analysis
#7
Sonilde Saraiva Januário, Florido Sampaio das Neves Peixoto, Nádia Nara Rolim Lima, Vânia Barbosa do Nascimento, Danilo Ferreira de Sousa, Dayse Christina Rodrigues Pereira Luz, Claúdio Gleidiston Lima da Silva, Modesto Leite Rolim Neto
INTRODUCTION: Studies about mental disorders are very rare in the Northeast of Brazil, especially when psychopathologies in children and adolescents are considered. The consequence is a small availability of data and an absence of a real epidemiological profile. METHODS: This is a systematic review with meta-analysis, following the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) protocol, in the period from 2003 to 2015, using the databases LILACS, SciELO and BVS...
February 2017: International Journal of Social Psychiatry
https://www.readbyqxmd.com/read/28132761/restenosis-after-everolimus-eluting-vascular-scaffolding-angiographic-and-optical-coherence-tomography-characterization
#8
Jorge Chavarría, Javier Suárez de Lezo, Soledad Ojeda, Manuel Pan, José Segura, Francisco Mazuelos, Simona Espejo, José López, Miguel Romero, José Suárez de Lezo
INTRODUCTION AND OBJECTIVES: Coronary restenosis after bioresorbable vascular scaffold (BVS) implantation is infrequent and little information is available on the main characteristics of these lesions. The aim of this study was to assess restenotic lesions by using optical coherence tomography (OCT). METHODS: We studied 330 patients with coronary artery disease who received 398 BVS to treat 380 lesions. These patients were clinically and angiographically evaluated at follow-up and OCT was carried out on detection of restenosis...
October 27, 2016: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28122965/mycobacterium-tuberculosis-membrane-vesicles-inhibit-t-cell-activation
#9
Jaffre J Athman, Obondo J Sande, Sarah G Groft, Scott M Reba, Nancy Nagy, Pamela A Wearsch, Edward T Richardson, Roxana Rojas, W Henry Boom, Supriya Shukla, Clifford V Harding
Mycobacterium tuberculosis utilizes multiple mechanisms to evade host immune responses, and inhibition of effector CD4(+) T cell responses by M. tuberculosis may contribute to immune evasion. TCR signaling is inhibited by M. tuberculosis cell envelope lipoglycans, such as lipoarabinomannan and lipomannan, but a mechanism for lipoglycans to traffic from M. tuberculosis within infected macrophages to reach T cells is unknown. In these studies, we found that membrane vesicles produced by M. tuberculosis and released from infected macrophages inhibited the activation of CD4(+) T cells, as indicated by reduced production of IL-2 and reduced T cell proliferation...
March 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28116863/bvs-for-bifurcation-lesions-to-do-or-not-to-do-is-no-more-the-question
#10
EDITORIAL
Ashok Seth
Presents the intermediate term results of BVS in bifurcation lesions from a large database. Emphasizes the optimal technique of BVS implantation in this lesion subset which may influence outcomes. Prospective, large, protocol driven registries would define the role of BVS in bifurcation lesion.
January 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28115812/ivus-guided-implantation-of-bioresorbable-vascular-scaffolds-for-very-late-paclitaxel-stent-thrombosis
#11
Zhe-Zhong Lin, Wei-Ting Chang, Chun-Yen Chiang, Zhih-Cherng Chen, Po-Ming Ku
Bioresorbable vascular scaffold (BVS) implantation has been shown to be safe in patients with stable coronary disease, and effective against the thrombotic lesion and the in-stent restenosis (ISR) of the drug-eluting stent (DES). BVSs have the advantages of a snow racket concept, positive vessel remodeling, and better conformability compared with DES in acute coronary syndrome (ACS). We report on a young patient with ST-elevation myocardial infarction (STEMI) who presented to our emergency department arising from very late stent thrombosis (VLST) of a 2...
January 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/28115471/two-year-outcomes-of-bioresorbable-vascular-scaffold-versus-drug-eluting-stents-in-coronary-artery-disease-a-meta-analysis
#12
Ramez Nairooz, Marwan Saad, Partha Sardar, Wilbert S Aronow
BACKGROUND: Data regarding long-term clinical outcomes with everolimus-eluting bioresorbable vascular scaffold (BVS) versus second-generation drug-eluting stents (DES) are scarce. METHODS: We searched online databases until October 2016 for studies comparing BVS versus DES reporting outcomes at 2 years of follow-up. We performed a meta-analysis comparing BVS with DES across the spectrum of coronary artery disease (CAD). Random effects model OR was calculated for outcomes of interest including device-oriented composite events (DOCE; defined as composite of cardiac mortality, target vessel myocardial infarction (TV-MI), and ischaemia-driven target lesion revascularisation (TLR)), all-cause mortality, definite stent thrombosis, TV-MI and TLR...
January 23, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28077638/a-conserved-glycine-residue-is-required-for-proper-functioning-of-a-baculovirus-vp39-protein
#13
Susumu Katsuma, Ryuhei Kokusho
: The baculovirus VP39 is a major nucleocapsid protein essential for viral propagation. However, the critical domains or residues of the VP39 protein have not yet been identified. Here, we performed mutagenesis experiments of Bombyx mori nucleopolyhedrovirus (BmNPV) using 5-bromo-2' -deoxyuridine and isolated a BmNPV mutant that produced fewer occlusion bodies than the wild-type virus. This mutant also produced fewer infectious budded viruses (BVs), when compared with the wild-type virus in both cultured cells and B...
January 11, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28076536/-quality-of-life-of-family-caregivers-of-adults-with-spinal-cord-injury-a-systematic-review
#14
Cejane Oliveira Martins Prudente, Maysa Ferreira Martins Ribeiro, Celmo Celeno Porto
The scope of this study was to analyze the quality of life of family caregivers of adults with spinal cord injury. Two researchers conducted a systematic review independently, based on articles published between 2000 to 2014, using the key words quality of life and caregivers or family and spinal cord, in Portuguese, English and Spanish. The search was conducted in the Virtual Health Library (BVS) and the United States National Library of Medicine (PubMED) databases. Caregivers of tetraplegics have a worse quality of life than caregivers of paraplegics...
January 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28076449/long-term-follow-up-of-patients-after-percutaneous-coronary-intervention-with-everolimus-eluting-bioresorbable-vascular-scaffold
#15
Rafael Alexandre Meneguz-Moreno, José de Ribamar Costa, Freddy Antônio Britto Moscoso, Rodolfo Staico, Luiz Fernando Leite Tanajura, Marinella Patrizia Centemero, Auréa Jacob Chaves, Andrea Claudia Leão de Sousa Abizaid, Amanda Guerra de Moraes Rego E Sousa, Alexandre Antonio Cunha Abizaid
Background: Bioresorbable vascular scaffolds (BVS) were developed to improve the long-term results of percutaneous coronary intervention, restoring vasomotion. Objectives: To report very late follow-up of everolimus-eluting Absorb BVS (Abbott Vascular, Santa Clara, USA) in our center. Methods: Observational retrospective study, in a single Brazilian center, from August 2011 to October 2013, including 49 patients submitted to Absorb BVS implantation...
January 9, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28069611/bioresorbable-vascular-scaffolds-for-the-treatment-of-chronic-total-occlusions-an-international-multicenter-registry
#16
Satoru Mitomo, Toru Naganuma, Yusuke Fujino, Hiroyoshi Kawamoto, Sandeep Basavarajaiah, Michael Pitt, Wei-Hsian Yin, Damras Tresukosol, Antonio Colombo, Sunao Nakamura
BACKGROUND: There are only limited studies reporting clinical outcomes after bioresorbable vascular scaffold (BVS; Absorb; Abbott Vascular, Santa Clara, CA) implantation for coronary chronic total occlusions (CTO). The aim of this study was to evaluate the real-world feasibility and safety of BVS implantation for the treatment of CTO. METHODS AND RESULTS: We retrospectively evaluated CTO cases treated with BVS from a multicenter registry. The primary end point was target lesion failure defined as a composite of cardiac death, target vessel myocardial infarction, and clinically driven target lesion revascularization...
January 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28069383/transgenic-rnai-of-bmreepa-in-silkworms-can-enhance-the-resistance-of-silkworm-to-bombyxmori-nucleopolyhedrovirus
#17
Xiao-Long Dong, Tai-Hang Liu, Wei Wang, Cai-Xia Pan, Guo-Yu Du, Yun-Fei Wu, Malavika Adur, Min-Juan Zhang, Min-Hui Pan, Cheng Lu
Our previous study has identified a gene, BmREEPa, which affects BmNPV invasion in silkworm cells. In this study, we interfered with BmREEPa in silkworm larvae through transgenic technology and screened BmREEPa-RNAi silkworm strains (RP). We found the mortality in RP was lower than that in Dazao, when silkworm larvae were infected with BmNPV via oral and injection routes. And the expression level of VP39 was lower in RP than in Dazao in the group infected via injection. In the oral infection group, VP39 expression level showed significant reduction at 48 h post-infection...
January 6, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28069258/reference-values-for-human-posture-measurements-based-on-computerized-photogrammetry-a-systematic-review
#18
Ana Freire Macedo Ribeiro, Anke Bergmann, Thiago Lemos, Antônio Guilherme Pacheco, Maitê Mello Russo, Laura Alice Santos de Oliveira, Erika de Carvalho Rodrigues
OBJECTIVE: The main objective of this study was to review the literature to identify reference values for angles and distances of body segments related to upright posture in healthy adult women with the Postural Assessment Software (PAS/SAPO). METHODS: Electronic databases (BVS, PubMed, SciELO and Scopus) were assessed using the following descriptors: evaluation, posture, photogrammetry, physical therapy, postural alignment, postural assessment, and physiotherapy...
January 6, 2017: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/28067196/management-of-st-elevation-myocardial-infarction-in-young-patients-by-limiting-implantation-of-durable-intracoronary-devices-and-guided-by-optical-frequency-domain-imaging-proof-of-concept-study
#19
Nicolas Combaret, Géraud Souteyrand, Nicolas Barber-Chamoux, Guilhem Malcles, Aimé Amonchot, Bruno Pereira, Louis Le Bivic, Romain Eschalier, Romain Trésorier, Pascal Motreff
AIMS: To demonstrate the feasibility and safety of ST-elevation myocardial infarction (STEMI) management in young patients by limiting implantation of durable intracoronary devices (using bioresorbable stent or medical treatment alone). METHODS AND RESULTS: Patients <50 years admitted for STEMI with single vessel disease received a two-stage management strategy. During a second coronary angiography performed between day 2 and day 7, optical frequency domain imaging (OFDI) enabled to guide therapeutic management: i) in the case of a stenosis greater that 70% or plaque prolapse, implantation of a BVS; ii) in the other cases, continuation of medical management alone without stenting...
January 10, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28062867/guide-wire-a-sisted-cannulation-versus-conventional-contrast-to-prevent-pancreatitis-a-systematic-review-and-meta-analysis-based-on-randomized-control-trials
#20
Eduardo T de Moura, Eduardo G de Moura, Wanderley Bernardo, Spencer Cheng, Andre Kondo, Diogo T de Moura, Jose Bravo, Everson L Artifon
OBJECTIVE: Through this systematic review and meta-analysis, we aim to clarify the differences between these two techniques, thus improving primary success cannulation and reducing complications during endoscopic retrograde cholangiopancreatography, primarily pancreatitis. METHODS: A comprehensive search was conducted to search for data available up until June2015from the most important databases available in the health field: EMBASE, MEDLINE (via PubMed), Cochrane, LILACS and CENTRAL (via BVS), SCOPUS, the CAPES database (Brazil), and gray literature...
October 2016: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
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