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https://www.readbyqxmd.com/read/28812212/obesity-treatment-with-botulinum-toxin-a-is-not-effective-a-systematic-review-and-meta-analysis
#1
REVIEW
Fabio Bustamante, Vitor Ottoboni Brunaldi, Wanderley Marques Bernardo, Diogo Turiani H de Moura, Eduardo Turiani H de Moura, Manoel Galvão, Marco Aurélio Santo, Eduardo Guimarães H de Moura
The effectiveness of gastric injections of botulinum toxin-A (BTA) as primary treatment for obesity is not well known since results in literature are discrepant. Hence, we aimed to systematically review and meta-analyze the available data to assess the real effect of BTA therapy. We searched MEDLINE, Embase, Cochrane, SCOPUS, EBSCO, LILACS, and BVS. We considered eligible only randomized controlled trials enrolling obese patients comparing BTA versus saline injections. Our initial search identified 8811 records...
August 15, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28808246/how-context-alters-value-the-brain-s-valuation-and-affective-regulation-system-link-price-cues-to-experienced-taste-pleasantness
#2
Liane Schmidt, Vasilisa Skvortsova, Claus Kullen, Bernd Weber, Hilke Plassmann
Informational cues such as the price of a wine can trigger expectations about its taste quality and thereby modulate the sensory experience on a reported and neural level. Yet it is unclear how the brain translates such expectations into sensory pleasantness. We used a whole-brain multilevel mediation approach with healthy participants who tasted identical wines cued with different prices while their brains were scanned using fMRI. We found that the brain's valuation system (BVS) in concert with the anterior prefrontal cortex played a key role in implementing the effect of price cues on taste pleasantness ratings...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28799238/everolimus-eluting-bioresorbable-vascular-scaffold-implantation-to-treat-saphenous-vein-graft-disease-single-center-initial-experience
#3
Fabien Picard, Guillaume Marquis-Gravel, Robert Avram, Hung Q Ly, Jean-François Dorval, Serge Doucet, Quentin de Hemptinne, Philippe L L'allier, Jean-François Tanguay
AIMS: Recent studies have shown favorable outcomes with everolimus-eluting bioresorbable vascular scaffold (BVS) in patients with stable coronary artery disease. Data on the use of BVS in saphenous vein graft disease (SVG) is currently lacking. METHODS AND RESULTS: A total of 10 consecutive patients (13 lesions, including 6 in-stent restenosis) who underwent BVS for SVG disease between May 2013 and June 2015 at a tertiary care institution were included. Median follow-up period was 874 (720-926) days...
August 10, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/28792157/optical-coherence-tomography-and-stent-boost-imaging-guided-bioresorbable-vascular-scaffold-overlapping-for-coronary-chronic-total-occlusion-lesion
#4
Hu Li, Seung Woon Rha, Cheol Ung Choi, Dong Joo Oh
We report herein the optical coherence tomography (OCT) and stent boost imaging guided bioresorbable vascular scaffold (BVS) implantation for right coronary artery (RCA) chronic total occlusion (CTO) lesion. The gold standard for evaluating BVS expansion after percutaneous coronary intervention is OCT. However, stent boost imaging is a new technique that improves fluoroscopy-based assessments of stent overlapping, and the present case shows clinical usefulness of OCT and stent boost imaging guided 'overlapping' BVS implantation via antegrade approach for a typical RCA CTO lesion...
September 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28781241/stent-malapposition-and-the-risk-of-stent-thrombosis-mechanistic-insights-from-an-in-vitro-model
#5
Nicolas Foin, Shengjie Lu, Jaryl Ng, Heerajnarain Bulluck, Derek J Hausenloy, Philip E Wong, Renu Virmani, Michael Joner
AIMS: To examine the effect of under-expansion on stent thrombogenicity with an in-vitro perfusion model. METHOD AND RESULTS: Drug eluting stent (DES) samples were partially under-deployed in silicone tubes and perfused with porcine blood containing 10% Anticoagulant Citrate Dextrose solution for 4 minutes at a flow rate of 200ml/min. Thrombus formation was evaluated and compared between the well apposed and malapposed sections. The malapposed sections showed significantly more thrombus formation compared to the well apposed sections (13...
August 8, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28780589/development-of-brain-ventricular-system
#6
REVIEW
Vladimir Korzh
The brain ventricular system (BVS) consists of brain ventricles and channels connecting ventricles filled with cerebrospinal fluid (CSF). The disturbance of CSF flow has been linked to neurodegenerative disease including hydrocephalus, which manifests itself as an abnormal expansion of BVS. This relatively common developmental disorder has been observed in human and domesticated animals and linked to functional deficiency of various cells lineages facing BVS, including the choroid plexus or ependymal cells that generate CSF or the ciliated cells that cilia beating generates CSF flow...
August 5, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28766253/imaging-assessment-of-bioresorbable-vascular-scaffolds
#7
REVIEW
Yohei Sotomi, Pannipa Suwannasom, Erhan Tenekecioglu, Carlos Collet, Shimpei Nakatani, Takayuki Okamura, Takashi Muramatsu, Yuki Ishibashi, Hiroki Tateishi, Yosuke Miyazaki, Taku Asano, Yuki Katagiri, Constantin von Zur Muehlen, Kengo Tanabe, Ken Kozuma, Yukio Ozaki, Patrick W Serruys, Yoshinobu Onuma
Vascular reparative therapy has become a reality with bioresorbable scaffolds (BRSs). To assess acute and long-term performance of the device, multimodality imaging would be essential. Radiopacity of metal hinders the imaging assessment, whereas radiolucent polymeric scaffolds allow for a precise imaging assessment with either invasive or non-invasive modality at baseline and at follow-up, which is one of the advantages of polymeric BRSs. Recent large trials evaluating clinical results of the first-generation BRS technology raised concerns about the safety and efficacy of these devices, namely, scaffold thrombosis...
August 1, 2017: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/28756388/drug-eluting-stents-in-clinical-routine-a-1-year-follow-up-analysis-based-on-german-health-insurance-administrative-data-from-2008-to-2014
#8
Elke Jeschke, Julia Searle, Christian Günster, Henning Thomas Baberg, Peter Dirschedl, Benny Levenson, Jürgen Malzahn, Thomas Mansky, Martin Möckel
OBJECTIVES: To describe the use of drug-eluting stents (DESs) in the largest population of statutory health insurance members in Germany, including newly developed bio-resorbable vascular scaffolds (BVSs), and to evaluate 1-year complication rates of DES as compared with bare metal stents (BMSs) in this cohort. DESIGN: Routine data analysis of statutory health insurance claims data from the years 2008 to 2014. SETTING: The German healthcare insurance Allgemeine Ortskrankenkasse covers approximately 30% of the German population and is the largest nationwide provider of statutory healthcare insurance in Germany...
July 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/28752868/a-waugh-type-como9o32-6-cluster-with-atomically-dispersed-co-iv-originates-from-anderson-type-como6o24-3-for-photocatalytic-oxygen-molecule-activation
#9
Yongdong Chen, Chaolei Zhang, Caoping Yang, Jiangwei Zhang, Kai Zheng, Qihua Fang, Gao Li
An atomically dispersed Waugh type [CoMo9O32](6-) cluster is obtained, employing the most flexible structure unit Anderson type [Co(OH)6Mo6O18](3-) as a precursor. The structure of the [CoMo9O32](6-) cluster is identified by single crystal X-ray diffraction and also well characterized by FT-IR, ESI-MS, UV-Vis, EA, and TGA spectroscopy. Its 3D framework forms a quasi 2D material and possesses curved edge triangle shape nanopores with a diameter of 8.9 Å. The Co(IV) and Mo(VI) oxidation states and the related valence band and electronic state of Co are definitely confirmed by X-ray photoelectron spectroscopy (XPS), ultraviolet photoemission spectroscopy (UPS), and bond valence sum (BVS)...
July 28, 2017: Nanoscale
https://www.readbyqxmd.com/read/28748256/bioresorbable-vascular-scaffolds-in-interventional-neuroradiology
#10
Anil Arat, Ergun Daglioglu, Ilkay Akmangit, Ahmet Peker, Murat Arsava, Mehmet Akif Topcuoglu, Deniz Belen
PURPOSE: Bioresorbable vascular scaffolds (BVS) have changed practice patterns in cardiology. These resorbable stents have not yet been utilized in the cerebrovascular circulation. We report the initial experiences with these devices in interventional neuroradiology. METHODS: A retrospective review of clinical presentations, imaging findings and follow-up results of all patients treated using a BVS by our neurovascular team was carried out using hospital electronic charts and the hospital radiographic archive system...
July 26, 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/28735764/bmp-2-7-heterodimer-strongly-induces-bone-regeneration-in-the-absence-of-increased-soft-tissue-inflammation
#11
Takashi Kaito, Tokimitsu Morimoto, Yuki Mori, Sadaaki Kanayama, Takahiro Makino, Shota Takenaka, Yusuke Sakai, Satoru Otsuru, Yoshichika Yoshioka, Hideki Yoshikawa
BACKGROUND CONTEXT: Bone morphogenetic protein (BMP)-2/7 heterodimer is a stronger inducer of bone regeneration than individual homodimers. However, clinical application of its potent bone induction ability may be hampered if its use is accompanied by excessive inflammatory reactions. PURPOSE: We sought to quantitatively evaluate bone induction and inflammatory reactions by BMP heterodimer and corresponding BMP homodimers using ultra-high resolution magnetic resonance imaging (MRI) and micro-computed tomography...
July 20, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28734923/diagnostic-accuracy-of-coronary-ct-angiography-for%C3%A2-the-evaluation-of-bioresorbable-vascular-scaffolds
#12
Carlos Collet, Bernard Chevalier, Angel Cequier, Jean Fajadet, Marcello Dominici, Steffen Helqvist, A J Van Boven, Dariusz Dudek, Dougal McClean, Manuel Almeida, Jan J Piek, Erhan Tenekecioglu, Antonio Bartorelli, Stephan Windecker, Patrick W Serruys, Yoshinobu Onuma
OBJECTIVES: To assess the diagnostic accuracy of coronary computed tomography angiography (CTA) for bioresorbable vascular scaffold (BVS) evaluation. BACKGROUND: Coronary CTA has emerged as a noninvasive method to evaluate patients with suspected or established coronary artery disease. The diagnostic accuracy of coronary CTA to evaluate angiographic outcomes after BVS implantation has not been well established. METHODS: In the ABSORB II (A Bioresorbable Everolimus-Eluting Scaffold Versus a Metallic Everolimus-Eluting Stent II) study, patients were randomized either to receive treatment with the BVS or everolimus-eluting metallic stent...
July 13, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28732815/2-year-outcomes-with-the-absorb-bioresorbable-scaffold-for-treatment-of-coronary-artery-disease-a-systematic-review-and-meta-analysis-of-seven-randomised-trials-with-an-individual-patient-data-substudy
#13
Ziad A Ali, Patrick W Serruys, Takeshi Kimura, Runlin Gao, Stephen G Ellis, Dean J Kereiakes, Yoshinobu Onuma, Charles Simonton, Zhen Zhang, Gregg W Stone
BACKGROUND: Bioresorbable vascular scaffolds (BVS) offer the potential to improve long-term outcomes of percutaneous coronary intervention after their complete bioresorption. Randomised trials have shown non-inferiority between BVS and metallic drug-eluting stents at 1 year in composite safety and effectiveness outcomes, although some increases in rates of target vessel-related myocardial infarction and device thrombosis were identified. Outcomes of BVS following the first year after implantation are unknown...
July 18, 2017: Lancet
https://www.readbyqxmd.com/read/28724084/comparison-of-models-and-whole-genome-profiling-approaches-for-genomic-enabled-prediction-of-septoria-tritici-blotch-stagonospora-nodorum-blotch-and-tan-spot-resistance-in-wheat
#14
Philomin Juliana, Ravi P Singh, Pawan K Singh, Jose Crossa, Jessica E Rutkoski, Jesse A Poland, Gary C Bergstrom, Mark E Sorrells
The leaf spotting diseases in wheat that include Septoria tritici blotch (STB) caused by , Stagonospora nodorum blotch (SNB) caused by , and tan spot (TS) caused by pose challenges to breeding programs in selecting for resistance. A promising approach that could enable selection prior to phenotyping is genomic selection that uses genome-wide markers to estimate breeding values (BVs) for quantitative traits. To evaluate this approach for seedling and/or adult plant resistance (APR) to STB, SNB, and TS, we compared the predictive ability of least-squares (LS) approach with genomic-enabled prediction models including genomic best linear unbiased predictor (GBLUP), Bayesian ridge regression (BRR), Bayes A (BA), Bayes B (BB), Bayes Cπ (BC), Bayesian least absolute shrinkage and selection operator (BL), and reproducing kernel Hilbert spaces markers (RKHS-M), a pedigree-based model (RKHS-P) and RKHS markers and pedigree (RKHS-MP)...
July 2017: Plant Genome
https://www.readbyqxmd.com/read/28707440/everolimus-eluting-bioresorbable-vascular-scaffolds-can-we-absorb-the-risk-in-complex-pci
#15
EDITORIAL
Firas Zahr, Joaquin E Cigarroa
BVS, as compared with DES, have higher stent thrombosis (ST) rates. BVS may prove reasonable in patients with complex anatomy. Future trials will be necessary to guide clinicians regarding whether BVS are equivalent to DES in patients with noncomplex or complex coronary anatomy.
July 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28707316/ticagrelor-and-absorb-bioresorbable-vascular-scaffold-implantation-for-recovery-of-vascular-function-after-successful-chronic-total-occlusion-recanalization-tiger-bvs-trial-rationale-and-study-design
#16
Salvatore Brugaletta, Josep Gomez-Lara, Juan Caballero, Luis Ortega-Paz, Luis Teruel, Miriam Jimenez Fernandez, Rafael Romaguera, Vicente Alcalde Martinez, Marcos Ñato, Eduardo Molina Navarro, Joan-Antoni Gomez-Hospital, Concepcion Correa Vilches, Maria Joyera, Angel Cequier, Manel Sabate
OBJECTIVES: To explore the role of ticagrelor versus clopidogrel in coronary blood flow normalization immediately after chronic coronary total occlusion (CTO) recanalization. BACKGROUND: Coronary vascular function of a CTO immediately after recanalization is demonstrated to be poor. METHODS: The TIGER BVS is a prospective, double-randomized, open-label, two parallel-group controlled clinical trial to evaluate efficacy of ticagrelor versus clopidogrel in improving vascular function of coronary segment distal to CTO immediately after CTO recanalization...
July 14, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28705057/applicability-and-procedural-success-rate-of-bioresorbable-vascular-scaffolds-for-percutaneous-coronary-intervention-in-an-all-comer-cohort-of-383-consecutive-patients
#17
Christian Schlundt, Stephan Achenbach, Fabiola Felten, Jens Roether, Mohamed Marwan, Holger Nef, Josef Ludwig, Monique Tröbs
Objectives The purpose of this study was to determine applicability and procedural success of bioresorbable vascular scaffolds (BVS) for percutaneous coronary intervention (PCI) in an all-comer cohort. Background BVS use in bifurcations and severely calcified lesions is not recommended, and a relatively large crossing profile may cause limitations. It is has never been studied how widely BVS can be applied in all-comer cohorts. Methods In 383 consecutive patients (acute coronary syndrome: 124, stable coronary disease 259), a BVS (Absorb) was used as first-line device unless any of the following contraindications were present: bifurcation with side branch >2...
July 14, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28701488/comparative-biomechanical-behavior-and-healing-profile-of-a-novel-thinned-wall-ultrahigh-molecular-weight-amorphous-poly-l-lactic-acid-sirolimus-eluting-bioresorbable-coronary-scaffold
#18
Yanping Cheng, Pawel Gasior, Jing-Gang Xia, Kamal Ramzipoor, Chang Lee, Edward A Estrada, Daniell Dokko, Jenn C McGregor, Gerard B Conditt, Thomas McAndrew, Greg L Kaluza, Juan F Granada
BACKGROUND: Mechanical strength of bioresorbable scaffolds (BRS) is highly dependent on strut dimensions and polymer features. To date, the successful development of thin-walled BRS has been challenging. We compared the biomechanical behavior and vascular healing profile of a novel thin-walled (115 µm) sirolimus-eluting ultrahigh molecular weight amorphous poly-l-lactic acid-based BRS (APTITUDE, Amaranth Medical [AMA]) to Absorb (bioresorbable vascular scaffold [BVS]) using different experimental models...
July 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28699552/assessing-the-effects-of-interventions-for-aedes-aegypti-control-systematic-review-and-meta-analysis-of-cluster-randomised-controlled-trials
#19
Víctor Alvarado-Castro, Sergio Paredes-Solís, Elizabeth Nava-Aguilera, Arcadio Morales-Pérez, Lidia Alarcón-Morales, Norma Alejandra Balderas-Vargas, Neil Andersson
BACKGROUND: The Aedes aegypti mosquito is the vector for dengue fever, yellow fever, chikungunya, and zika viruses. Inadequate vector control has contributed to persistence and increase of these diseases. This review assesses the evidence of effectiveness of different control measures in reducing Aedes aegypti proliferation, using standard entomological indices. METHODS: A systematic search of Medline, Ovid, BVS, LILACS, ARTEMISA, IMBIOMED and MEDIGRAPHIC databases identified cluster randomised controlled trials (CRCTs) of interventions to control Aedes aegypti published between January 2003 and October 2016...
May 30, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28697473/biophysical-studies-on-the-interaction-of-a-novel-oxime-based-palladium-ii-complex-with-dna-and-rna
#20
Nirmalya Bandyopadhyay, Pritha Basu, Gopinatha Suresh Kumar, Bhargab Guhathakurta, Pijush Singh, Jnan Prakash Naskar
A novel oxime based palladium(II) complex (1) has been synthesized out of the reaction of a Schiff base ligand, 1-phenyl-1-(pyridin-2-yl-hydrazono)-propan-2-one oxime (LH2) with Na2[PdCl4] in THF. Red and diamagnetic 1 has thoroughly been characterized by several analytical and spectroscopic means like CHN, ESI-MS, FAB-MS, FT-IR, (1)H NMR, (13)C NMR, UV-Vis and molar electrical conductivity measurements. Geometry optimizations at the level of DFT reveals that the Pd(II) centre in 1 is nested in a square-planar 'N3Cl' coordination environment...
July 1, 2017: Journal of Photochemistry and Photobiology. B, Biology
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