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https://www.readbyqxmd.com/read/29786537/complete-two-year-follow-up-with-formal-non-inferiority-testing-on-primary-outcomes-of-the-aida-trial-comparing-the-absorb-bioresorbable-scaffold-with-the-xience-drug-eluting-metallic-stent-in-routine-pci
#1
Ruben Yannick G Tijssen, Robin P Kraak, Sjoerd H Hofma, Rene J van der Schaaf, Karin Arkenbout, Auke Weevers, Joelle Elias, Ivo M van Dongen, Karel T Koch, Jan Baan, Marije Vis, Robbert J de Winter, Jan J Piek, Jan G P Tijssen, Jose P S Henriques, Joanna J Wykrzykowska
AIMS: The aim of this report of the AIDA trial is to provide full two-year outcomes for the primary endpoint of target vessel failure (TVF) and an update on device thrombosis. METHODS AND RESULTS: AIDA was a single-blind, multicentre, investigator-initiated, non-inferiority, randomised (1:1) clinical trial. At complete two-year follow-up, the primary endpoint of TVF had occurred in 100 patients in the Absorb BVS arm versus 90 patients in the XIENCE EES arm (HR 1...
May 22, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29765733/elaboration-structural-study-and-validation-of-a-new-nasicon-type-structure-na-0-72-cr-0-48-al-1-52-mo-2-77-al-0-23-o-12
#2
Manel Sonni, Imen Jendoubi, Mohamed Faouzi Zid
The title compound, sodium chromium/aluminium molybdenum/aluminium dodeca-oxide, Na0.72 Cr0.48 Al1.74 Mo2.77 O12 , was prepared by solid-state reaction. Its crystal structure is related to NaSICON-type compounds. The framework is built up from M 1O6 ( M 1 = Cr/Al) octa-hedra and M 2O4 ( M 2 = Mo/Al) tetra-hedra inter-connected by corners. The three-dimensional framework contains cavities in which sodium cations are located. Two validation models (BVS and CHARDI) were used to confirm the proposed structural model...
March 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/29751828/augmentative-and-alternative-communication-in-children-with-down-s-syndrome-a-systematic-review
#3
Renata Thaís de Almeida Barbosa, Acary Souza Bulle de Oliveira, Jennifer Yohanna Ferreira de Lima Antão, Tânia Brusque Crocetta, Regiani Guarnieri, Thaiany Pedrozo Campos Antunes, Claudia Arab, Thaís Massetti, Italla Maria Pinheiro Bezerra, Carlos Bandeira de Mello Monteiro, Luiz Carlos de Abreu
BACKGROUND: The use of technology to assist in the communication, socialization, language, and motor skills of children with Down's syndrome (DS) is required. The aim of this study was to analyse research findings regarding the different instruments of 'augmentative and alternative communication' used in children with Down's syndrome. METHODS: This is a systematic review of published articles available on PubMed, Web of Science, PsycInfo, and BVS using the following descriptors: assistive technology AND syndrome, assistive technology AND down syndrome, down syndrome AND augmentative and alternative communication...
May 11, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29742143/mid-term-outcomes-of-the-absorb-bvs-versus-second-generation-des-a-systematic-review-and-meta-analysis
#4
Cordula M Felix, Victor J van den Berg, Sanne E Hoeks, Jiang Ming Fam, Mattie Lenzen, Eric Boersma, Peter C Smits, Patrick W Serruys, Yoshinobu Onuma, Robert Jan M van Geuns
BACKGROUND: Bioresorbable Vascular Scaffolds (BVS) were introduced to overcome some of the limitations of drug-eluting stent (DES) for PCI. Data regarding the clinical outcomes of the BVS versus DES beyond 2 years are emerging. OBJECTIVE: To study mid-term outcomes. METHODS: We searched online databases (PubMed/Medline, Embase, CENTRAL), several websites, meeting presentations and scientific session abstracts until August 8th, 2017 for studies comparing Absorb BVS with second-generation DES...
2018: PloS One
https://www.readbyqxmd.com/read/29732926/imaging-guided-pre-dilatation-stenting-post-dilatation-ipsp-a-protocolized-approach-highlighting-the-importance-of-intravascular-imaging-for-implantation-of-bioresorbable-scaffolds
#5
Ziad A Ali, Keyvan Karimi Galougahi, Richard Shlofmitz, Akiko Maehara, Gary S Mintz, Alexandre Abizaid, Daniel Chamié, Jonathan Hill, Patrick W Serruys, Yoshinobu Onuma, Gregg W Stone
The advent of the fully bioresorbable vascular scaffold (BVS) is the latest step in a series of advancements in the design of intracoronary stents over the past few decades. The novelty of this technology is in providing temporary vessel scaffolding and local antiproliferative therapy to prevent neointimal hyperplasia after percutaneous coronary intervention followed by gradual resorption of the scaffold to restore the native vessel anatomy and physiology-a process termed vascular reparative therapy. Areas covered: The first generation of BVS has not been able to fully match the high benchmark in safety and efficacy set by contemporary metallic drug-eluting stents...
May 7, 2018: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/29731419/is-there-a-direct-correlation-between-microvascular-wall-structure-and-k-trans-values-obtained-from-perfusion-ct-measurements-in-lymphomas
#6
Marius Horger, Petra Fallier-Becker, Wolfgang M Thaiss, Alexander Sauter, Hans Bösmüller, Manuela Martella, Heike Preibsch, Jan Fritz, Konstantin Nikolaou, Christopher Kloth
RATIONALE AND OBJECTIVES: This study aimed to test the hypothesis that ultrastructural wall abnormalities of lymphoma vessels correlate with perfusion computed tomography (PCT) kinetics. MATERIALS AND METHODS: Our local institutional review board approved this prospective study. Between February 2013 and June 2016, we included 23 consecutive subjects with newly diagnosed lymphoma, who were referred for computed tomography-guided biopsy (6 women, 17 men; mean age, 60...
May 3, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29699614/neoatherosclerosis-5-years-after-bioresorbable-vascular-scaffold-implantation
#7
Noriaki Moriyama, Koki Shishido, Yutaka Tanaka, Shohei Yokota, Takahiro Hayashi, Hirokazu Miyashita, Tatsuya Koike, Hiroaki Yokoyama, Takuma Takada, Takashi Nishimoto, Tomoki Ochiai, Kazuki Tobita, Futoshi Yamanaka, Shingo Mizuno, Masato Murakami, Saeko Takahashi, Shigeru Saito
BACKGROUND: Data regarding neoatherosclerosis after everolimus-eluting bioresorbable vascular scaffold (BVS) (ABSORB BVS Rev. 1.1, Abbott Vascular, Santa Clara, California) implantation are limited. OBJECTIVES: This study investigated the findings of neoatherosclerosis at 5 years after BVS 1.1 implantation by using multi-imaging modalities, including optical coherence tomography (OCT). METHODS: Patients included in the ABSORB EXTEND (ABSORB EXTEND Clinical Investigation) trial at Shonan Kamakura General Hospital underwent OCT at baseline after the index procedure and at 1 and 5 years...
May 1, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29696533/tirofiban-positively-regulates-%C3%AE-1-integrin-and-favours-endothelial-cell-growth-on-polylactic-acid-biopolymer-vascular-scaffold-bvs
#8
Arturo Giordano, Simona Romano, Nicola Corcione, Giacomo Frati, Giuseppe Biondi Zoccai, Paolo Ferraro, Stefano Messina, Stefano Ottolini, Maria Fiammetta Romano
An unexpectedly high incidence of thrombosis in patients that received the polylactic acid bioresorbable vascular scaffold (BVS) suggests a delayed/incomplete endothelial repair with this stent. The anti-platelet agent tirofiban stimulates endothelial cell migration and proliferation, mediated by VEGF production. We investigated the tirofiban effect on the migration and adhesion of endothelial cells to BVS, in vitro. We performed human umbilical endothelial cell (HUVEC) cultures in the presence of BVS. Tirofiban, similarly to VEGF, increased the ability of HUVEC to grow on the vascular scaffold, compared to unstimulated or abciximab-treated cells...
April 25, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29696428/heart-rate-variability-and-cardiopulmonary-dysfunction-in-patients-with-duchenne-muscular-dystrophy-a-systematic-review
#9
REVIEW
Talita Dias da Silva, Thais Massetti, Tânia Brusque Crocetta, Carlos Bandeira de Mello Monteiro, Alex Carll, Luiz Carlos Marques Vanderlei, Carlie Arbaugh, Fernando Rocha Oliveira, Luiz Carlos de Abreu, Celso Ferreira Filho, John Godleski, Celso Ferreira
Duchenne muscular dystrophy (DMD) is a genetic recessive disorder with progressive muscle weakness. Despite the general muscle wasting, degeneration and necrosis of cardiomyocytes have been the main causes of morbidity and death in individuals with DMD. Cardiac failure is generally preceded by disturbances in heart rate variability (HRV), and non-invasive measurement of the autonomic nervous system has been an important tool to predict adverse cardiovascular events. Hence, the application of HRV to study autonomic modulation in DMD individuals, and the establishment of correlations between HRV and heart/lung diseases, age, and mortality will have the potential to improve quality of life and life expectancy of individuals with DMD...
April 25, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29688175/implantation-techniques-pre-dilatation-sizing-and-post-dilatation-and-the-incidence-of-scaffold-thrombosis-and-revascularization-in-lesions-treated-with-an-everolimus-eluting-bioresorbable-vascular-scaffold-insights-from-the-aida-trial
#10
Ruben Yannick G Tijssen, Robin P Kraak, Joelle Elias, Ivo M van Dongen, Deborah Nancy Kalkman, Martina Nassif, Yohei Sotomi, Taku Asano, Yuki Katagiri, Carlos Collet, Jan J Piek, Jose P S Henriques, Robbert J de Winter, Jan G Tijssen, Yoshinobu Onuma, Patrick W Serruys, Joanna J Wykrzykowska
AIMS: Absorb bioresorbable vascular scaffold (Absorb BVS) specific implantation strategies have been proposed to optimize outcomes. We analyzed whether the occurrence of definite scaffold thrombosis (ScT) and target lesion revascularization (TLR) in Absorb-treated AIDA patients was influenced by scaffold implantation techniques. METHODS AND RESULTS: Absorb BVS implantation in 1074 lesions was graded according to definitions of optimal implantation based on pre-dilatation, sizing, and post-dilatation (PSP)...
April 24, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29676725/bombyx-mori-nucleopolyhedrovirus-orf40-is-essential-for-budded-virus-production-and-occlusion-derived-virus-envelopment
#11
Yunwang Shen, Min Feng, Xiaofeng Wu
ORF40 (bm40) of the Bombyx mori nucleopolyhedrovirus (BmNPV) encodes a homologue of Autographa californica multiple nucleopolyhedrovirus (AcMNPV) AC51 and is a highly conserved gene in sequenced alphabaculoviruses. To investigate the role of bm40 in the baculovirus infection cycle, a bm40 knockout BmNPV bacmid was constructed via homologous recombination in Escherichia coli. Western blotting analysis revealed that bm40 is a late gene during virus infection. Compared with wild-type and repair viruses, the knockout virus exhibited a single-cell infection phenotype...
April 19, 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29656280/real-world-bioresorbable-vascular-scaffold-experience-compared-with-second-generation-metallic-drug-eluting-stents-in-complex-coronary-lesions
#12
Naotaka Okamoto, Hiroshi Ueda, Takahiro Yoshimura, Surbhi Chamaria, Samit Bhatheja, Yuliya Vengrenyuk, Samaneh Rabiei, Yonandy Barrientos, Vishal Kapur, Nitin Barman, Joseph Sweeny, Usman Baber, Roxana Mehran, Samin K Sharma, Annapoorna S Kini
OBJECTIVES: The aim of the study was to compare the acute outcomes of Absorb bioresorbable vascular scaffolds (BVS) and second-generation drug-eluting stent (DES) implantation in routine clinical practice. There is a paucity of data regarding BVS use in a real-world patient population. METHODS: The study population comprised 40 consecutive patients who underwent percutaneous coronary intervention (PCI) with BVS implantation at a tertiary-care center in New York, New York between July and December of 2016...
April 15, 2018: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/29649724/evaluation-of-upper-limb-movements-in-children-with-down-s-syndrome-a-systematic-review
#13
REVIEW
Jamile Benite Palma Lopes, Renata Calhes Franco de Moura, Roberta Delasta Lazzari, Natalia de Almeida Carvalho Duarte, Arislander Jonathan Lopes Dumont, Claudia Santos Oliveira
The aim of the present study was to perform a review of the literature on current quantitative clinical methods for the evaluation of upper limb movements in children and adolescents with Down syndrome, with a focus on describing the variables, protocols, motor function and motor control. METHODS: A survey of PubMed, Scielo, BVS Bireme and PEDro databases using the following key words: upper limb and EMG and Down syndrome; upper limb and kinematics and Down syndrome; upper limb and motion analysis and Down syndrome; movement and upper limb and Down syndrome; upper limb and Down syndrome; reach and Down syndrome...
April 9, 2018: Infant Behavior & Development
https://www.readbyqxmd.com/read/29649071/predictors-of-early-scaffold-thrombosis-results-from-the-multicenter-prospective-german-austrian-absorb-registry
#14
Jochen Wöhrle, Holger M Nef, Christoph Naber, Stephan Achenbach, Thomas Riemer, Julinda Mehilli, Thomas Münzel, Steffen Schneider, Sinisa Markovic, Julia Seeger, Wolfgang Rottbauer, Thomas Pfannebecker, Gert Richardt, Ralf Zahn, Tommaso Gori, Johannes Kastner, Axel Schmermund, Christian W Hamm
BACKGROUND: In randomized clinical trials, the risk of thrombotic events with the absorb bioresorbable vascular scaffold (BVS) was significantly higher than with metallic drug-eluting stents. We evaluated predictors of scaffold thrombosis in the large-scale, multicenter German-Austrian ABSORB RegIstRy. METHODS AND RESULTS: 3178 patients with treatment of 4252 lesions using 5020 scaffolds were included. Follow-up rate at 6 months was 97.4%. Forty-five (1.42%) patients experienced definite/probable scaffold thrombosis during follow-up...
April 11, 2018: Coronary Artery Disease
https://www.readbyqxmd.com/read/29643237/the-functional-oligomeric-state-of-tegument-protein-gp41-is-essential-for-baculovirus-bv-and-odv-assembly
#15
Yimeng Li, Shu Shen, Liangbo Hu, Fei Deng, Just M Vlak, Zhihong Hu, Hualin Wang, Manli Wang
gp41 , one of the baculovirus core genes, encodes the only recognized tegument (O-glyco) protein of the occlusion-derived virion (ODV) phenotype so far. A previous study using a temperature-sensitive Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV) mutant showed that GP41 plays a crucial role in budded virion (BV) formation. However, the precise function of GP41 in the baculovirus replication cycle remains unclear. In this study, AcMNPV GP41 was found to accumulate around the ring zone region (RZ) within the infected nucleus and finally assembled into both BV and ODV...
April 11, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29622143/bioresorbable-scaffold-for-treatment-of-coronary-artery-lesions-intravascular-ultrasound-results-from-the-absorb-japan-trial
#16
Kozo Okada, Yasuhiro Honda, Hideki Kitahara, Kyuhachi Otagiri, Shigemitsu Tanaka, M Brooke Hollak, Paul G Yock, Jeffrey J Popma, Hajime Kusano, Wai-Fung Cheong, Krishnankutty Sudhir, Peter J Fitzgerald, Takeshi Kimura
OBJECTIVES: The aim of this study was to characterize post-procedural intravascular ultrasound (IVUS) findings in the ABSORB Japan trial, specifically stratified by the size of target coronary arteries. BACKGROUND: Despite overall noninferiority confirmed in recent randomized trials comparing bioresorbable vascular scaffolds (BVS) (Absorb BVS) and cobalt-chromium everolimus-eluting metallic stents (CoCr-EES), higher event rates of Absorb BVS have been reported with suboptimal deployment, especially in small coronary arteries...
April 9, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29605821/within-subject-and-between-subject-biological-variation-estimates-of-21-hematological-parameters-in-30-healthy-subjects
#17
Abdurrahman Coşkun, Anna Carobene, Meltem Kilercik, Mustafa Serteser, Sverre Sandberg, Aasne K Aarsand, Pilar Fernandez-Calle, Niels Jonker, William A Bartlett, Jorge Díaz-Garzón, Sibel Huet, Cansu Kızıltaş, Ilayda Dalgakıran, Esra Ugur, Ibrahim Unsal
BACKGROUND: The complete blood count (CBC) is used to evaluate health status in the contexts of various clinical situations such as anemia, infection, inflammation, trauma, malignancies, etc. To ensure safe clinical application of the CBC, reliable biological variation (BV) data are required. The study aim was to define the BVs of CBC parameters employing a strict protocol. METHODS: Blood samples, drawn from 30 healthy subjects (17 females, 13 males) once weekly for 10 weeks, were analyzed using a Sysmex XN 3000 instrument...
April 2, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29605704/spent-coffee-ground-as-a-new-bulking-agent-for-accelerated-biodrying-of-dewatered-sludge
#18
Zongdi Hao, Benqin Yang, Deokjin Jahng
The feasibility of using spent coffee ground (SCG) as a new bulking agent for biodrying of dewatered sludge (DS) was investigated in comparison with two other frequently-used bulking agents, air-dried sludge (AS) and sawdust (SD). Results showed that the moisture contents (MC) of 16-day DS biodrying with AS (Trial A), SCG (Trial B) and SD (Trial C) decreased from 70.14 wt%, 68.25 wt% and 71.63 wt% to 59.12 wt%, 41.35 wt% and 57.69 wt%, respectively. In case of Trial B, the MC rapidly decreased to 46...
March 21, 2018: Water Research
https://www.readbyqxmd.com/read/29578542/a-tailorable-in-situ-light-activated-biodegradable-vascular-scaffold
#19
Mazen S Albaghdadi, Jian Yang, Jessica H Brown, Neel A Mansukhani, Guillermo A Ameer, Melina R Kibbe
Biodegradable vascular scaffolds (BVS) are novel treatments for obstructive atherosclerotic cardiovascular disease that have been developed to overcome the limitations of traditional metallic drug-eluting stents (DES). The mechanical properties of bioabsorbable polymers used for the production of novel BVS are a key consideration for the clinical translation of this emerging technology. Herein, we describe the engineering of an in situ light-activated vascular scaffold (ILVS) comprised of a biodegradable citric acid-based elastomeric polymer, referred to as methacrylated poly-diol citrate (mPDC), and a diazeniumdiolate chitosan nitric oxide donor (chitoNO)...
April 2017: Advanced materials technologies
https://www.readbyqxmd.com/read/29558949/hemodynamics-of-cerebral-bridging-veins-connecting-the-superior-sagittal-sinus-based-on-numerical-simulation
#20
Youyu Zhu, Feng Wang, Xuefei Deng
BACKGROUND: The physiological and hemodynamic features of bridging veins involve wall shear stress (WSS) of the cerebral venous system. Based on the data of cadavers and computational fluid dynamics software pack, the hemodynamic physical models of bridging veins (BVs) connecting superior sagittal sinus (SSS) were established. RESULTS: A total of 137 BVs formed two clusters along the SSS: anterior group and posterior group. The diameters of the BVs in posterior group were larger than of the anterior group, and the entry angle was smaller...
March 20, 2018: Biomedical Engineering Online
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