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https://www.readbyqxmd.com/read/29679638/inhibition-of-immunoproteasome-promotes-angiogenesis-via-enhancing-hypoxia-inducible-factor-1%C3%AE-abundance-in-rats-following-focal-cerebral-ischaemia
#1
Xingyong Chen, Xu Zhang, Ting Chen, Xiulong Jiang, Xiaosong Wang, Huixin Lei, Yinzhou Wang
Angiogenesis after ischemic stroke contributes to the restoration of blood supply in the ischemic zone. Strategies to improve angiogenesis may facilitate the function recovery after stroke. Growing evidence shows that proteasome inhibitors enhance angioneurogenesis and induces a long-term neuroprotection after cerebral ischemia in rodents' models. We have previously reported that inhibition of the immunoproteasome subunit low molecular mass peptide 2 (LMP2) offers a strong neuroprotection in ischemic stroke rats...
April 18, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29678953/metabolic-adjustment-to-high-altitude-hypoxia-from-genetic-signals-to-physiological-implications
#2
REVIEW
Andrew J Murray, Hugh E Montgomery, Martin Feelisch, Michael P W Grocott, Daniel S Martin
Ascent to high altitude is associated with physiological responses that counter the stress of hypobaric hypoxia by increasing oxygen delivery and by altering tissue oxygen utilisation via metabolic modulation. At the cellular level, the transcriptional response to hypoxia is mediated by the hypoxia-inducible factor (HIF) pathway and results in promotion of glycolytic capacity and suppression of oxidative metabolism. In Tibetan highlanders, gene variants encoding components of the HIF pathway have undergone selection and are associated with adaptive phenotypic changes, including suppression of erythropoiesis and increased blood lactate levels...
April 20, 2018: Biochemical Society Transactions
https://www.readbyqxmd.com/read/29678877/deferoxamine-ameliorates-adipocyte-dysfunction-by-modulating-iron-metabolism-in-ob-ob-mice
#3
Hong-Fa Yan, Zhao-Yu Liu, Zhi-Ang Guan, Chuang Guo
OBJECTIVE: The mechanisms underlying obesity and anti-obesity processes have garnered remarkable attention as potential therapeutic targets for obesity-associated metabolic syndromes. Our prior work has shown the healing efficacy of iron reduction therapies for hepatic steatosis in a rodent model of diabetes and obesity. In this study, we investigated how iron depletion by deferoxamine (DFO) affected adipocyte dysfunction in the epididymal adipose tissues of ob/ob mice. METHODS: Male ob/ob mice were assigned to either a vehicle-treated or DFO-treated group...
April 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29678661/role-of-heat-shock-transcription-factor-1-hsf1-upregulated-macrophage-in-ameliorating-pressure-overload-induced-heart-failure-in-mice
#4
Peizhao Du, Yaowei Chang, Fangjie Dai, Chunyan Wei, Qi Zhang, Jiming Li
In order to explore the role of macrophages in HSF1-mediated alleviation of heart failure, mice model of pressure overload-induced heart failure was established using transverse aortic constriction (TAC). Changes in cardiac function and morphology were studied in TAC and SHAM groups using ultrasonic device, tissue staining, electron microscopy, real-time quantitative polymerase chain reaction (RT-QPCR), and Western blotting. We found that mice in the TAC group showed evidence of impaired cardiac function and aggravation of fibrosis on ultrasonic and histopathological examination when compared to those in the SHAM group...
April 17, 2018: Gene
https://www.readbyqxmd.com/read/29676955/mitochondrial-genome-modulates-myocardial-akt-glut-hk-salvage-pathway-in-spontaneously-hypertensive-rats-adapted-to-chronic-hypoxia
#5
Iveta Nedvedova, David Kolar, Barbara Elsnicova, Daniela Hornikova, Jiri Novotny, Martin Kalous, Michal Pravenec, Jan Neckar, Frantisek Kolar, Jitka M Zurmanova
Recently we have shown that adaptation to continuous normobaric hypoxia (CNH) decreases myocardial ischemia/reperfusion injury in spontaneously hypertensive rats (SHR) and in conplastic strain (SHR-mtBN ). The protective effect was stronger in the latter group characterized by a selective replacement of SHR mitochondrial genome with that of a more ischemia-resistant Brown Norway strain. The aim of the present study was to examine the possible involvement of the hypoxia inducible factor (HIF)-dependent pathway of the protein kinase B/glucose transporters/hexokinase (Akt/GLUT/HK) in this mitochondrial genome-related difference of the cardioprotective phenotype...
April 20, 2018: Physiological Genomics
https://www.readbyqxmd.com/read/29675970/does-hypoxia-inducible-factor-1-%C3%AE-hif-1-%C3%AE-c1772t-polymorphism-predict-short-term-prognosis-in-patients-with-oral-squamous-cell-carcinoma-oscc
#6
Jitender Prasad, Binita Goswami, Srinivas H Gowda, Nikhil Gupta, Shilpa Kumar, Kiran Agarwal, Pravesh Mehra, Bindiya K Pahuja, Anju Chauhan
BACKGROUND: Oral squamous cell carcinoma (OSCC) is a cancer of the oral cavity that is a major health problem in India. There is an urgent need to identify biomarkers that have prognostic significance. We studied HIF1 α levels as well as single nucleotide polymorphism of HIF1α gene in cancer and healthy controls. METHODS: Fifty newly diagnosed OSCC patients and 50 age and sex matched healthy control were included in the study. Serum concentrations of HIF1 α were measured by sandwich ELISA; whereas HIF1 α gene polymorphism study was done using restriction enzyme digestion by HpH I...
April 20, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29674976/neocytolysis-how-to-get-rid-of-the-extra-erythrocytes-formed-by-stress-erythropoiesis-upon-descent-from-high-altitude
#7
REVIEW
Heimo Mairbäurl
Neocytolysis is the selective destruction of those erythrocytes that had been formed during stress-erythropoiesis in hypoxia in order to increase the oxygen transport capacity of blood. Neocytolysis likely aims at decreasing this excess amount of erythrocytes and hemoglobin (Hb) when it is not required anymore and to decrease blood viscosity. Neocytolysis seems to occur upon descent from high altitude. Similar processes seem to occur in microgravity, and are also discussed to mediate the replacement of erythrocytes containing fetal hemoglobin (HbF) with those having adult hemoglobin (HbA) after birth...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29673320/intraspecific-variation-of-residual-heterozygosity-and-its-utility-for-quantitative-genetic-studies-in-maize
#8
Nannan Liu, Jianxiao Liu, Wenqiang Li, Qingchun Pan, Jie Liu, Xiaohong Yang, Jianbing Yan, Yingjie Xiao
BACKGROUND: Residual heterozygosity (RH) in advanced inbred lines of plants benefits quantitative trait locus (QTL) mapping studies. However, knowledge of factors affecting the genome-wide distribution of RH remains limited. RESULTS: A set of 2196 heterogeneous inbred family (HIF) maize lines derived from 12 recombinant inbred line (RIL) populations was genotyped using the Maize50K SNP chip. A total of 18,615 unique RH intervals were identified, ranging from 505 to 2095 intervals per population, with average maize genome coverage of 94...
April 19, 2018: BMC Plant Biology
https://www.readbyqxmd.com/read/29671738/hif-2%C3%AE-is-essential-for-carotid-body-development-and-function
#9
David Macias, Andrew S Cowburn, Hortensia Torres-Torrelo, Patricia Ortega-Sáenz, José López-Barneo, Randall Johnson
Mammalian adaptation to oxygen flux occurs at many levels, from shifts in cellular metabolism to physiological adaptations facilitated by the sympathetic nervous system and carotid body (CB). Interactions between differing forms of adaptive response to hypoxia, including transcriptional responses orchestrated by the Hypoxia Inducible transcription Factors (HIFs), are complex and clearly synergistic. We show here that there is an absolute developmental requirement for HIF-2α, one of the HIF isoforms, for growth and survival of oxygen sensitive glomus cells of the carotid body...
April 19, 2018: ELife
https://www.readbyqxmd.com/read/29671622/changes-in-kidney-tissue-and-effects-of-erythropoietin-after-acute-heart-failure
#10
A Güven Bağla, M Içkin Gülen, F Ercan, F Aşgün, E Ercan, C Bakar
Impairment of cardiac function causes renal damage. Renal failure after heart failure is attributed to hemodynamic derangement including reduced renal perfusion and increased venous pressure. One mechanism involves apoptosis and is defined as cardiorenal syndrome type 1. Erythropoietin (EPO) is a cytokine that induces erythropoiesis under hypoxic conditions. Hypoxia inducible factor 1 alpha (HIF-1α) plays a regulatory role in cellular response to hypoxia. Protective effects of EPO on heart, kidney and nervous system are unrelated to red blood cell production...
April 19, 2018: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/29670681/diaphragm-muscle-weakness-following-acute-sustained-hypoxic-stress-in-the-mouse-is-prevented-by-pretreatment-with-n-acetyl-cysteine
#11
Andrew J O'Leary, Sarah E Drummond, Deirdre Edge, Ken D O'Halloran
Oxygen deficit (hypoxia) is a major feature of cardiorespiratory diseases characterized by diaphragm dysfunction, yet the putative role of hypoxic stress as a driver of diaphragm dysfunction is understudied. We explored the cellular and functional consequences of sustained hypoxic stress in a mouse model. Adult male mice were exposed to 8 hours of normoxia, or hypoxia (FiO2  = 0.10) with or without antioxidant pretreatment (N-acetyl cysteine, 200 mg/kg i.p.). Ventilation and metabolism were measured. Diaphragm muscle contractile function, myofibre size and distribution, gene expression, protein signalling cascades, and oxidative stress (TBARS) were determined...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29670184/wogonin-attenuates-nasal-polyp-formation-by-inducing-eosinophil-apoptosis-through-hif-1%C3%AE-and-survivin-suppression
#12
Roza Khalmuratova, Mingyu Lee, Ji-Hun Mo, YunJae Jung, Jong-Wan Park, Hyun-Woo Shin
Chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) is an inflammatory sinonasal disorder characterized by eosinophilic inflammation and T-helper 2 skewing. Eosinophil accumulation in sinonasal mucosa comprises a major feature of CRSwNP. The study aimed to investigate the effect of the flavone wogonin in nasal polyposis by assessing its ability to induce eosinophil apoptosis in vitro and attenuate eosinophilic CRSwNP in mice. Double immunofluorescence, immunohistochemistry, flow cytometry, and immunoblotting were performed to evaluate hypoxia-inducible factor (HIF)-1α, survivin, and apoptotic markers in the human eosinophilic EoL-1 cell line or sinonasal tissues from patients with CRS with or without NPs...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29667230/nephropreventing-effect-of-hypoxia-inducible-factor-1%C3%AE-in-a-rat-model-of-ischemic-reperfusion-acute-kidney-injury
#13
Huiling Wang, Nanmei Liu, Rui Li, Jun Tian, Weifeng Hu, Jinyuan Zhang
Acute kidney injury (AKI) often occurs in 5% hospitalized patients and in 50% sepsis patients with acute renal dysfunction. However, there is no safe and effective therapeutic strategies until now. Hypoxia condition is closely related to renal injuries and function under AKI. As HIF-1α is critical for cellular response to hypoxia, we investigated the protective effect of HIF-1α in a rat AKI model. We found that HIF-1 α injection improved the survival of rat with AKI, and the level of Cr and BUN was also increased...
April 17, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29666970/histopathological-and-molecular-predictors-of-growth-patterns-and-recurrence-in-craniopharyngiomas-a-systematic-review
#14
REVIEW
Josephine R Coury, Brittany N Davis, Christoforos P Koumas, Giovanna S Manzano, Amir R Dehdashti
Craniopharyngiomas (CPs) are rare, benign tumors derived from Rathke's pouch, known for their high recurrence rates and associated morbidity and mortality. Despite significant investigation on risk factors for recurrence, a lack of consensus persists. Recent research suggests that specific histopathological and molecular characteristics are prognostic for disease progression. In this systematic review, we analyzed and consolidated key features of CPs that contribute to increased recurrence rates. This systematic review was performed in accordance with PRISMA guidelines...
April 17, 2018: Neurosurgical Review
https://www.readbyqxmd.com/read/29666476/hif1a-inactivation-rescues-photoreceptor-degeneration-induced-by-a-chronic-hypoxia-like-stress
#15
Maya Barben, Divya Ail, Federica Storti, Katrin Klee, Christian Schori, Marijana Samardzija, Stylianos Michalakis, Martin Biel, Isabelle Meneau, Frank Blaser, Daniel Barthelmes, Christian Grimm
Reduced choroidal blood flow and tissue changes in the ageing human eye impair oxygen delivery to photoreceptors and the retinal pigment epithelium. As a consequence, mild but chronic hypoxia may develop and disturb cell metabolism, function and ultimately survival, potentially contributing to retinal pathologies such as age-related macular degeneration (AMD). Here, we show that several hypoxia-inducible genes were expressed at higher levels in the aged human retina suggesting increased activity of hypoxia-inducible transcription factors (HIFs) during the physiological ageing process...
April 17, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29666467/ascorbic-acid-induces-global-epigenetic-reprogramming-to-promote-meiotic-maturation-and-developmental-competence-of-porcine-oocytes
#16
Xiao-Xia Yu, Yun-Hua Liu, Xiao-Man Liu, Pei-Chao Wang, Shuai Liu, Jia-Kun Miao, Zhi-Qiang Du, Cai-Xia Yang
L-ascorbic acid (Vitamin C) can enhance the meiotic maturation and developmental competence of porcine oocytes, but the underlying molecular mechanism remains obscure. Here we show the role of ascorbic acid in regulating epigenetic status of both nucleic acids and chromatin to promote oocyte maturation and development in pigs. Supplementation of 250 μM L-ascorbic acid 2-phosphate sesquimagnesium salt hydrate (AA2P) during in vitro maturation significantly enhanced the nuclear maturation (as indicated by higher rate of first polar body extrusion and increased Bmp15 mRNA level), reduced level of reactive oxygen species, and promoted developmental potency (higher cleavage and blastocyst rates of parthenotes, and decreased Bax and Caspase3 mRNA levels in blastocysts) of pig oocytes...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29663500/knockdown-of-lncrna-uca1-suppresses-chemoresistance-of-pediatric-aml-by-inhibiting-glycolysis-through-the-microrna-125a-hexokinase-2-pathway
#17
Yuan Zhang, Yufeng Liu, Xueju Xu
Dysregulation of lncRNAs is implicated in chemoresistance in varieties of tumor including acute myeloid leukemia (AML). LncRNA urothelial carcinoma-associated 1 (UCA1) was reported to play an oncogenic role in AML. However, whether UCA1 was involved in chemoresistance in pediatric AML remains unclear. UCA1 expression in AML patients after adriamycin (ADR)-based chemotherapy and ADR-resistant AML cells was examined by qRT-PCR. The effects of UCA1 on the cytotoxicity of ADR and glycolysis were evaluated by MTT assay and measuring the glucose consumption and lactate production in HL60 and HL60/ADR cells, repectively...
April 16, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29662659/idh1-mutation-is-associated-with-lower-expression-of-vegf-but-not-microvessel-formation-in-glioblastoma-multiforme
#18
Jiří Polívka, Martin Pešta, Pavel Pitule, Ondřej Hes, Luboš Holubec, Jiří Polívka, Tereza Kubíková, Zbyněk Tonar
Introduction: Glioblastoma multiforme (GBM) represents the most malignant primary brain tumor characterized by pathological vascularization. Mutations in isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) were observed in GBM. We aimed to assess the intra-tumor hypoxia, angiogenesis and microvessel formation in GBM and to find their associations with IDH1 mutation status and patients prognosis. Methods: 52 patients with a diagnosis of GBM were included into the study...
March 27, 2018: Oncotarget
https://www.readbyqxmd.com/read/29662621/the-role-and-gene-expression-profile-of-socs3-in-colorectal-carcinoma
#19
Xing Dong, Jing Wang, Bo Tang, Yeng-Xue Hao, Ping-Yang Li, Shi-Yong Li, Pei-Wu Yu
SOCS3 has been postulated to play a role in the occurrence and progression of malignancies. However, the relationship of SOCS3 with colorectal carcinoma remains poorly understood. The purpose of the study was to explore the role of SOCS3 in colorectal carcinoma and its underlying mechanisms. Protein and mRNA expression of SOCS3 in colorectal carcinoma and normal colorectal mucosa was detected using immunohistochemistry and real-time quantitative PCR. SOCS3 expression was significantly lower in colorectal carcinoma tissue than in normal colorectal mucosa, and was negatively correlated with tumor invasion depth, lymph node metastasis, differentiation degree, and TNM stage...
March 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29662084/hoxa9-inhibits-hif-1%C3%AE-mediated-glycolysis-through-interacting-with-crip2-to-repress-cutaneous-squamous-cell-carcinoma-development
#20
Liang Zhou, Yinghui Wang, Meijuan Zhou, Ying Zhang, Pengfei Wang, Xiaoxing Li, Jing Yang, Hongmei Wang, Zhenhua Ding
Glycolytic reprogramming is a typical feature of many cancers; however, key regulators of glucose metabolism reengineering are poorly understood, especially in cutaneous squamous cell carcinoma (cSCC). Here, Homeobox A9 (HOXA9), a direct target of onco-miR-365, is identified to be significantly downregulated in cSCC tumors and cell lines. HOXA9 acts as a tumor suppressor and inhibits glycolysis in cSCC in vitro and in vivo by negatively regulating HIF-1α and its downstream glycolytic regulators, HK2, GLUT1 and PDK1...
April 16, 2018: Nature Communications
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