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https://www.readbyqxmd.com/read/29691625/cytoreductive-surgery-and-intraperitoneal-hyperthermic-chemotherapy-hipec-by-minimally-invasive-approach-an-initial-experience
#1
A Arjona-Sanchez, S Rufian-Peña, J M Sanchez-Hidalgo, A Casado-Adam, A Cosano-Alvarez, J Briceño-Delgado
BACKGROUND: The cytoreductive surgery (CRS) associated with hyperthermic intraperitoneal chemotherapy (HIPEC) has become the standard treatment in patients with carcinomatosis peritoneal from different origins. The use of a minimally invasive approach for this high complex procedure might be an alternative that provides them less morbidity and faster recovery with similar oncologic outcomes. METHODS: We describe the initial experience of CRS and HIPEC done via the laparoscopic route in patients with minimal peritoneal metastases in our Unit from March 2016 to January 2018...
April 24, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29689546/eno2-promotes-cell-proliferation-glycolysis-and-glucocorticoid-resistance-in-acute-lymphoblastic-leukemia
#2
Cheng-Cheng Liu, Hua Wang, Wei-da Wang, Liang Wang, Wen-Jian Liu, Jing-Hua Wang, Qi-Rong Geng, Yue Lu
BACKGROUND/AIMS: The metabolic features of cancer cells have long been acknowledged to be altered and to provide new therapeutic opportunities. The expression of glycolytic enzyme enolase 2 (ENO2) was found to be closely associated with the clinical features of acute lymphoblastic leukemia (ALL) patients, but its functions remain unclear in ALL. METHODS: We evaluated the association between ENO2 mRNA expression in bone marrow mononuclear cells (BM-MNCs) and the efficacy of chemotherapy, and further explored the function of ENO2 in ALL...
April 19, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29687881/relapse-in-teenage-and-young-adult-patients-treated-on-a-paediatric-minimal-residual-disease-stratified-all-treatment-protocol-is-associated-with-a-poor-outcome-results-from-ukall2003
#3
Rob S Sellar, Clare Rowntree, Ajay J Vora, Caroline L Furness, Nicholas Goulden, Chris Mitchell, Anthony V Moorman, Rachael Hough
Outcomes for teenage and young adult (TYA) patients with acute lymphoblastic leukaemia (ALL) who relapse on contemporary risk-adapted paediatric protocols are largely unknown and there is no consensus on optimal salvage strategies. We assessed the treatment and outcome of TYA patients (aged 16-24 years) recruited to the UKALL2003 trial, who relapsed following attainment of complete morphological remission. Forty-two of 223 patients (18·8%) relapsed, the majority (n = 26, 62%) on treatment. Thirty-eight (90%) patients received salvage treatment, with 22 (58%) achieving second remission (CR2) and 21 patients receiving an allogeneic haematopoietic cell transplant (alloHSCT)...
April 24, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29687559/-no-evidence-of-disease-activity-is-it-an-appropriate-surrogate-in-multiple-sclerosis
#4
Harald Hegen, Gabriel Bsteh, Thomas Berger
The increasing number of disease-modifying treatments available for multiple sclerosis (MS) has broadened treatment options for patients, but also challenges clinicians to select the best therapy for each individual at the appropriate stage of the disease. Early prediction of treatment response still remains one of the main difficulties in the management of MS patients. The concept of "no evidence of disease activity"(NEDA) has been proposed as surrogate for treatment response based on the absence of relapses, disability progression and radiological activity...
April 24, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29687310/genotype-and-phenotype-in-multiple-sclerosis-potential-for-disease-course-prediction
#5
REVIEW
Vilija G Jokubaitis, Yuan Zhou, Helmut Butzkueven, Bruce V Taylor
PURPOSE OF REVIEW: This review will examine the current evidence that genetic and/or epigenetic variation may influence the multiple sclerosis (MS) clinical course, phenotype, and measures of MS severity including disability progression and relapse rate. RECENT FINDINGS: There is little evidence that MS clinical phenotype is under significant genetic control. There is increasing evidence that there may be genetic determinants of the rate of disability progression...
April 24, 2018: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/29687219/attempting-to-stop-antipsychotic-medication-success-supports-and-efforts-to-cope
#6
Miriam Larsen-Barr, Fred Seymour, John Read, Kerry Gibson
PURPOSE: To explore supports and coping strategies used during attempts to discontinue antipsychotic medication and test for associations with success. METHOD: 144 people who were taking or had taken antipsychotics completed The Experiences of Antipsychotic Medication Survey. Among them, 105 people had made at least one discontinuation attempt and answered a series of questions about their most recent attempt to stop. Content analysis and Chi-square tests of independence were used to categorise the data and explore associations...
April 23, 2018: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/29687208/could-68-ga-psma-pet-ct-become-a-new-tool-in-the-decision-making-strategy-of-prostate-cancer-patients-with-biochemical-recurrence-of-psa-after-radical-prostatectomy-a-preliminary-monocentric-series
#7
Berardino De Bari, Rosario Mazzola, Dario Aiello, Sergio Fersino, Fabiana Gregucci, Pierpaolo Alongi, Maurizio Nicodemo, Stefano Cavalleri, Matteo Salgarello, Filippo Alongi
AIM: To evaluate the impact of gallium68 PSMA-11 (HBED-CC)-PET/CT on decision-making strategy of patients with relapsing prostate cancer (PC) presenting a second biochemical relapse after radical prostatectomy (RP) and salvage RT or salvage androgen deprivation therapy (ADT). MATERIALS AND METHODS: 40 patients were retrospectively analyzed. All of them had received prostatectomy. Thirteen out of 40 were addressed to gallium68 PSMA-11 (HBED-CC)-PET/CT for a biochemical relapse after RP, 14/40 after a salvage RT and 13/40 after salvage or adjuvant ADT...
April 23, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29686996/the-utility-of-18-f-fdg-pet-ct-for-monitoring-response-and-predicting-prognosis-after-glucocorticoids-therapy-for-sarcoidosis
#8
Hengyi Chen, Rongbing Jin, Yubo Wang, Li Li, Kunlin Li, Yong He
Sarcoidosis has significant heterogeneity involving multiple organs; treatment of the disease is a significant therapeutic challenge due to the difficulties in accurately monitoring disease activity and estimating prognosis. Fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG-PET/CT) plays an important role in assessing the metabolic activity. However, there is not enough evidence about the influence of this method in the clinical management and prognosis prediction for sarcoidosis...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29685997/a-strong-sense-of-coherence-associated-with-reduced-risk-of-anxiety-disorder-among-women-in-disadvantaged-circumstances-british-population-study
#9
Olivia Remes, Nicholas W J Wainwright, Paul Surtees, Louise Lafortune, Kay-Tee Khaw, Carol Brayne
OBJECTIVE: Many patients receiving medical treatment for anxiety relapse or do not improve. Research has therefore been turning to coping mechanisms as a way to decrease anxiety rates. Previously, we showed that living in a deprived area significantly increases the risk of anxiety in women, but not in men. The objective of this study is to assess whether sense of coherence (coping mechanism) buffers the influence of area deprivation on women's risk of generalised anxiety disorder using data from the European Prospective Investigation of Cancer-Norfolk...
April 23, 2018: BMJ Open
https://www.readbyqxmd.com/read/29685738/-idiopathic-orbital-inflammatory-syndrome-report-of-24-cases
#10
S Khochtali, M Zayani, I Ksiaa, I Ben Meriem, S Zaouali, B Jelliti, M Khairallah
BACKGROUND: Idiopathic orbital inflammatory syndrome (IOIS) is an inflammatory condition of unknown etiology. The inflammation may affect all the structures within the orbit (anterior, diffuse, apical, myositic, dacryoadenitis) and corresponds to uniquely orbital inflammation without an identifiable local cause or systemic disease. The goal of this study is to describe the clinical and radiographic characteristics of IOIS and discuss the role of orbital biopsy in this condition. PATIENTS AND METHODS: This is a retrospective review of the charts of 24 patients diagnosed with IOIS at Fattouma Bourguiba hospital, Monastir, Tunisia, from January 2007 to December 2015...
April 20, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29685206/chaos-theory-for-clinical-manifestations-in-multiple-sclerosis
#11
Tetsuya Akaishi, Toshiyuki Takahashi, Ichiro Nakashima
Multiple sclerosis (MS) is a demyelinating disease which characteristically shows repeated relapses and remissions irregularly in the central nervous system. At present, the pathological mechanism of MS is unknown and we do not have any theories or mathematical models to explain its disseminated patterns in time and space. In this paper, we present a new theoretical model from a viewpoint of complex system with chaos model to reproduce and explain the non-linear clinical and pathological manifestations in MS...
June 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29685115/acquired-modification-of-sphingosine-1-phosphate-lyase-activity-is-not-related-to-adrenal-insufficiency
#12
Gulin Sunter, Ece Oge Enver, Azad Akbarzade, Serap Turan, Pinar Vatansever, Dilek Ince Gunal, Goncagul Haklar, Abdullah Bereket, Kadriye Agan, Tulay Guran
BACKGROUND: Congenital sphingosine-1-phosphate (S1P) lyase deficiency due to biallelic mutations in SGPL1 gene has recently been described in association with primary adrenal insufficiency and steroid-resistant nephrotic syndrome. S1P lyase, on the other hand, is therapeutically inhibited by fingolimod which is an oral drug for relapsing multiple sclerosis (MS). Effects of this treatment on adrenal function has not yet been evaluated. We aimed to test adrenal function of MS patients receiving long-term fingolimod treatment...
April 23, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29684893/comparison-of-the-moca-and-bearni-tests-for-detection-of-cognitive-impairment-in-in-patients-with-alcohol-use-disorders
#13
Stéphanie Pelletier, Régis Alarcon, Valérie Ewert, Margot Forest, Bertrand Nalpas, Pascal Perney
INTRODUCTION: Screening of cognitive impairment is a major challenge in alcoholics seeking treatment, since cognitive dysfunction may impair the overall efficacy of rehabilitation programs and consequently increase relapse rate. We compared the performance of two screening tools: the MoCA (Montreal Cognitive Assessment), which is widely used in patients with neurological diseases and already used in patients with alcohol use disorder (AUD), and the BEARNI (Brief Evaluation of Alcohol-Related Neuropsychological Impairments), a recent test specifically developed for the alcoholic population...
April 10, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29684471/glucocorticoid-receptors-in-the-basolateral-amygdala-mediated-the-restraint-stress-induced-reinstatement-of-methamphetamine-seeking-behaviors-in-rats
#14
Zahra Taslimi, Abdolrahman Sarihi, Abbas Haghparast
Methamphetamine (METH) addiction is a growing epidemic worldwide. It is a common psychiatric disease and stress has an important role in the drug seeking and relapse behaviors. The involvement of the basolateral amygdala (BLA) in effects of stress on the reward pathway has been discussed in several studies. In this study, we tried to find out the involvement of glucocorticoid receptors (GRs) in the BLA in stress-induced reinstatement of the extinguished METH-induced conditioned place preference (CPP) in rats...
April 20, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29682982/resection-of-medial-talocalcaneal-coalition-with-interposition-of-a-pediculated-flap-of-tibialis-posterior-tendon-sheath
#15
Jan Hubert, Thelonius Hawellek, Frank Timo Beil, Dominik Saul, Jens Henning Kling, Christoph Viebahn, Oliver Jungesblut, Ralf Stücker, Martin Rupprecht
BACKGROUND: The purpose of the study was to present a novel operative technique in the management of medial talocalcaneal coalition (TC) and to report our clinical and radiologic results after interposition of a pediculated flap (PF) of the tibialis posterior tendon sheath. METHODS: Twelve feet of 10 patients with a medial TC were treated with the interposition of PF of the tibialis posterior tendon sheath following resection. Pre- and postoperative clinical examinations were performed to evaluate the range of motion and the function of the tibialis posterior muscle of the affected foot...
April 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29682493/the-frequency-of-clinic-visits-was-not-associated-with-medication-adherence-or-outcome-in-children-with-inflammatory-bowel-diseases
#16
Cheryl Kluthe, Jenkin Tsui, Donald Spady, Matthew Carroll, Eytan Wine, Hien Quoc Huynh
Background: Medication nonadherence is a challenge in pediatric patients with inflammatory bowel diseases (IBD). Poor adherence can result in disease flare-ups, disease complicationstherapy escalation, and the need for corticosteroids. The aim was to determine if clinic visit frequency was associated with treatment adherence. Methods: A retrospective chart review of patients attending the Edmonton Pediatric IBD Clinic (EPIC) at the Stollery Children's Hospital from January 2012 to December 2013 was completed...
2018: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29682368/transformation-of-t-cell-acute-lymphoblastic-lymphoma-to-peripheral-t-cell-lymphoma-a-report-of-two-cases
#17
Michael Markow, Abu-Sayeef Mirza, Lia Perez, Haipeng Shao, Pedro Horna, Claudio Anasetti, Lubomir Sokol, Mohammad O Hussaini
Nonhepatosplenic/noncutaneous γδ peripheral T-cell lymphoma (NHNC γδ PTCL) represents a miscellaneous group of unrelated T-cell lymphomas of which only isolated cases have been reported. We describe two cases of transformation from T-lymphoblastic leukemia/lymphoma to NHNC γδ PTCL. Transformation into more aggressive disease is a rare event in T-cell lineage-derived hematologic malignancies compared to B-cell neoplasms. Nevertheless, both of our cases involved relapse as PTCL manifested with skin involvement and an overt shift from blastic morphology to large granular leukemia-like mature T cells...
2018: Case Reports in Hematology
https://www.readbyqxmd.com/read/29682172/momelotinib-decreased-cancer-stem-cell-associated-tumor-burden-and-prolonged-disease-free-remission-period-in-a-mouse-model-of-human-ovarian-cancer
#18
Emily Chan, Rodney Luwor, Christopher Burns, George Kannourakis, Jock K Findlay, Nuzhat Ahmed
Despite a good initial response to front-line chemotherapy, majority of the ovarian cancer patients relapse with consecutive phases of recurrences; and nearly 60% die within 5 years due to the development of a chemoresistant disease. This study investigated whether inhibition of the Janus kinase 2 (JAK2)-signal transducer and activator of transcription 3 (STAT3) pathway by momelotinib is sufficient in suppressing tumor burden and prolonging the disease-free survival period in a mouse model of ovarian cancer...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29680992/comparison-of-mucosal-and-mucoperiosteal-wound-cover-for-the-treatment-of-medication-related-osteonecrosis-of-the-jaw-lesions-a-retrospective-cohort-study
#19
Nicola Nonnenmühlen, A Burnic, A Bartella, B Lethaus, F Gerhards, O Ristow, C Pautke, F Hölzle, T Steiner
OBJECTIVES: Actually, there is no detailed guidance on how to deal with wound closure after surgical removal of medication-related osteonecrosis of the jaw (MRONJ) lesions. This study attempts to compare the difference in outcome between the mucosal and the mucoperiosteal flap closure after surgery. PATIENTS AND METHODS: In this retrospective monocentric cohort study, patients (n = 61; 35 female/26 male) suffering from MRONJ and requiring surgical therapy at the University of Aachen between 2013 and 2015 were included...
April 22, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29680419/a-randomised-controlled-trial-of-bright-light-therapy-and-morning-activity-for-adolescents-and-young-adults-with-delayed-sleep-wake-phase-disorder
#20
C Richardson, N Cain, K Bartel, G Micic, B Maddock, M Gradisar
A randomised controlled trial evaluated bright light therapy and morning activity for the treatment of Delayed Sleep-Wake Phase Disorder (DSWPD) in young people. 60 adolescents and young adults (range = 13-24 years, mean = 15.9 ± 2.2 y, 63% f) diagnosed with DSWPD were randomised to receive three weeks of post-awakening Green Bright Light Therapy (∼507 nm) and Sedentary Activity (sitting, watching TV), Green Bright Light Therapy and Morning Activity (standing, playing motion-sensing videogame), Red Light Therapy (∼643 nm) and Sedentary Activity or Red Light Therapy and Morning Activity...
May 2018: Sleep Medicine
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