keyword
MENU ▼
Read by QxMD icon Read
search

Colistin

keyword
https://www.readbyqxmd.com/read/28440853/antibiotic-strategies-for-eradicating-pseudomonas-aeruginosa-in-people-with-cystic-fibrosis
#1
REVIEW
Simon C Langton Hewer, Alan R Smyth
BACKGROUND: Respiratory tract infection with Pseudomonas aeruginosa occurs in most people with cystic fibrosis. Once chronic infection is established, Pseudomonas aeruginosa is virtually impossible to eradicate and is associated with increased mortality and morbidity. Early infection may be easier to eradicate.This is an update of a Cochrane review first published in 2003, and previously updated in 2006, 2009 and 2014. OBJECTIVES: To determine whether antibiotic treatment of early Pseudomonas aeruginosa infection in children and adults with cystic fibrosis eradicates the organism, delays the onset of chronic infection, and results in clinical improvement...
April 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28438945/multi-hospital-occurrence-of-pan-resistant-klebsiella-pneumoniae-st147-with-an-isecp1-directed-blaoxa-181-insertion-into-the-mgrb-gene-in-the-united-arab-emirates
#2
Ágnes Sonnevend, Akela Ghazawi, Rayhan Hashmey, Aliasgher Haidermota, Safinaz Girgis, Mubarak Alfaresi, Mohammed Omar, David L Paterson, Hosam M Zowawi, Tibor Pál
The emergence of pan-resistant Klebsiella pneumoniae strains is an increasing concern. In the current study we describe a cluster of 9 pan-resistant K. pneumoniae ST147 isolates encountered in 4 patients over nearly one year in 3 hospitals of the United Arab Emirates. The isolates exhibited highly similar genotypes. All produced chromosomally encoded OXA-181 and the majority also produced the NDM-5 carbapenemase. Similarly to the previously described single isolate from the UAE, MS6671, the mgrB was disrupted by a functional, ISEcp1-driven blaOXA-181 insertion causing resistance to carbapenems...
April 24, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28438944/genomic-insights-into-mcr-1-positive-plasmids-carried-by-the-colistin-resistant-escherichia-coli-from-the-inpatients
#3
Qingjing Wang, Jian Sun, Youfa Ding, Xing-Ping Li, Ya-Hong Liu, Youjun Feng
Colistin, a family of cationic polypeptide antibiotics, acts as a final resort against infections by the multidrug-resistant Gram-negative pathogens.….
April 24, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28438940/emergence-of-plasmid-mediated-mcr-1-gene-in-clinical-kpc-2-producing-klebsiella-pneumoniae-st392-in-brazil
#4
Caio Augusto Martins Aires, Orlando Carlos da Conceição-Neto, Thamirys Rachel Tavares E Oliveira, Carolina Frizzera Dias, Lara Feital Montezzi, Renata Cristina Picão, Rodolpho Mattos Albano, Marise Dutra Asensi, Ana Paula D'Alincourt Carvalho-Assef
Since the first report of the plasmid-mediated colistin resistance mcr-1 gene in Escherichia coli and Klebsiella pneumoniae isolates from China (1), mcr-1 had already spread to most continents, being detected in different species from several sources, including in carbapenemase-producing clinical isolates (2).….
April 24, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28438937/incx2-and-incx1-x2-hybrid-plasmids-coexisting-in-fosa6-producing-escherichia-coli
#5
Qinglan Guo, Jiachun Su, Christi Lee McElheny, Nicole Stoesser, Yohei Doi, Minggui Wang
IncX plasmids are receiving much attention as vehicles of carbapenem and colistin resistance genes, such as blaNDM, blaKPC and mcr-1 Among them, IncX2 subgroup plasmids remain rare. Here we characterized IncX2 and IncX1-X2 hybrid plasmids coexisting in a FosA6-producing Escherichia coli strain, which were possibly generated as a consequence of recombination events between an R6K-like IncX2 plasmid and a pLN126_33-like IncX1 plasmid. Variable multidrug resistance mosaic regions were observed in these plasmids indicating their potential to serve as flexible carriers of resistance genes...
April 24, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28438568/a-novel-mutation-in-pmrb-mediates-colistin-resistance-during-therapy-of-acinetobacter-baumannii
#6
Elias Dahdouh, Rosa Gómez-Gil, Sonia Sanz, Bruno González-Zorn, Ziad Daoud, Jesús Mingorance, Monica Suárez
Acinetobacter baumannii is a highly versatile nosocomial pathogen. Multidrug resistance among A. baumannii isolates led to the use of colistin, subsequently giving rise to colistin-resistant strains. In this study, the genetic and phenotypic profiles of two colistin-resistant A. baumannii isolates were investigated. Two A. baumannii isolates were obtained from Patient 1 (C071 and C440) and three isolates were obtained from Patient 2 (C080, C314 and C428). Susceptibility profiles were determined by VITEK(®)2 and Etest...
April 21, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28437233/in-vitro-activity-of-various-antibiotics-in-combination-with-tigecycline-against-acinetobacter-baumannii-a-systematic-review-and-meta-analysis
#7
Jian Li, Xianghai Yang, Lidan Chen, Xinran Duan, Zhihui Jiang
Given that tigecycline-based combination therapy is recognized as a valuable option for the treatment of tigecycline-resistant Acinetobacter baumannii, we conducted this systematic review and meta-analysis to assess the overall evidence of its effectiveness. The synergy rate was defined as the primary outcome that was calculated separately for time-kill, Etest, and checkerboard microdilution methods. The secondary outcomes were bactericidal activity and the efficacy of combination treatment on the development of resistance...
April 24, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28437232/epidemiological-physiological-and-molecular-characteristics-of-a-brazilian-collection-of-carbapenem-resistant-acinetobacter-baumannii-and-pseudomonas-aeruginosa
#8
Vanessa Cordeiro Dias, Juliana Alves Resende, André Netto Bastos, Lucas Quinet De Andrade Bastos, Victor Quinet De Andrade Bastos, Ricardo Villela Bastos, Cláudio Galuppo Diniz, Vânia Lúcia Da Silva
Nonfermenting Gram-negative bacteria such as Pseudomonas aeruginosa and Acinetobacter baumannii are widespread in the environment and are increasingly associated with nosocomial infections, often associated with multidrug-resistance phenotypes. This study aimed to evaluate epidemiological, physiological, and molecular characteristics of carbapenem resistance in P. aeruginosa and A. baumannii. In total, 63 nonreplicated strains (44 A. baumannii and 19 P. aeruginosa) were isolated from hospitalized patients. Antimicrobial resistance patterns, biocide tolerance, oxidative stress, hemolytic activity, and biofilm formation were assessed...
February 24, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28427842/predominance-of-international-clone-2-oxa-23-producing-acinetobacter-baumannii-clinical-isolates-in-greece-2015-results-of-a-nationwide-study
#9
Spyros Pournaras, Konstantina Dafopoulou, Mariateresa Del Franco, Olympia Zarkotou, Evangelia Dimitroulia, Efi Protonotariou, Aggeliki Poulou, Raffaele Zarrilli, Athanasios Tsakris
In a previous nationwide study in Greece, OXA-58 was the sole carbapenemase present among carbapenem-resistant Acinetobacter baumannii (CRAB) isolated between 2000 and 2009. In this study, the antibiotic resistances, carbapenemase gene content and clonal relatedness of 194 single-patient CRAB clinical isolates collected randomly during 2015 from 11 tertiary hospitals located throughout Greece were investigated. Antimicrobial susceptibility was determined using commercial and dilution methods. PCR for carbapenemase genes were performed...
April 18, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28421056/high-prevalence-of-colistin-resistance-and-mcr-1-gene-in-escherichia-coli-isolated-from-food-animals-in-china
#10
Xianhui Huang, Linfeng Yu, Xiaojie Chen, Chanping Zhi, Xu Yao, Yiyun Liu, Shengjun Wu, Zewen Guo, Linxian Yi, Zhenling Zeng, Jian-Hua Liu
The objective of this study was to determine the minimal inhibitory concentration of colistin for Escherichia coli from food animals and the possible underlying colistin resistance mechanisms. During 2007-2014, 4,438 E. coli isolates of food animal origins were collected. The susceptibility of colistin was tested by the agar dilution method. Mutations in pmrA, pmrB, and mgrB and the presence of mcr-1 gene were determined by PCR and DNA sequencing. Complementation experiments were carried out to evaluate the contribution of the mutations to colistin resistance...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28420384/molecular-characteristic-of-mcr-1-producing-escherichia-coli-in-a-chinese-university-hospital
#11
Qing-Wen He, Xiao-Hong Xu, Fang-Jun Lan, Zhi-Chang Zhao, Zhi-Yun Wu, Ying-Ping Cao, Bin Li
BACKGROUND: Colistin has been considered as a last-line treatment option in severe infections caused by multidrug-resistant (MDR) gram-negative pathogens. However, the emergence of the mobile colistin resistance gene (mcr-1) has challenged this viewpoint. The aim of this study is to explore the prevalence of mcr-1 in Escherichia coli (E. coli) in a Chinese teaching hospital, and investigate their molecular characteristics. METHODS: A total of 700 E. coli isolates were used to screen mcr-1 by PCR and sequencing in a Chinese university hospital from August 2014 to August 2015...
April 19, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28418313/mcr-1-colistin-resistance-in-esbl-producing-klebsiella-pneumoniae-france
#12
Yvan Caspar, Mylène Maillet, Patricia Pavese, Gilles Francony, Jean-Paul Brion, Marie-Reine Mallaret, Richard Bonnet, Frédéric Robin, Racha Beyrouthy, Max Maurin
We report intestinal carriage of an extended-spectrum β-lactamase-producing Klebsiella pneumoniae strain with high-level resistance to colistin (MIC 24 mg/L) in a patient in France who had been hospitalized for fungal meningitis. The strain had the mcr-1 plasmid gene and an inactivated mgrB gene, which are associated with colistin resistance.
May 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28416556/colistin-resistant-mcr-1-positive-escherichia-coli-in-public-beaches-an-infectious-threat-emerging-in-recreational-waters
#13
Miriam R Fernandes, Fábio P Sellera, Fernanda Esposito, Caetano P Sabino, Louise Cerdeira, Nilton Lincopan
The emergence and rapid spread of colistin-resistant Escherichia coli carrying the mcr-1 gene has generated an urgent need to strengthen surveillance. We have performed a meticulous investigation of strains of this sort, resulting in the first identification of international clones of E. coli carrying IncX4 plasmid-mediated mcr-1 and blaCTX-M genes in recreational waters of public urban beaches in cities with high tourist turnover, highlighting a new environmental reservoir.
April 17, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28416554/in-vitro-study-of-isapl1-mediated-mobilization-of-the-colistin-resistance-gene-mcr-1
#14
Laurent Poirel, Nicolas Kieffer, Patrice Nordmann
The plasmid-mediated mcr-1 gene encodes a phosphoethanolamine transferase conferring resistance to polymyxins. The mcr-1 gene is associated with insertion sequence ISApl1 (IS30 family). In-vitro mobilization assays demonstrated the functionality of the composite transposon structure ISApl1-mcr-1-ISApl1 Transposition generated a 2-bp duplication and occurred in AT-rich DNA regions. This is the first report demonstrating the mobility of the mcr-1 gene by transposition.
April 17, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28416545/dissemination-of-mcr-1-carrying-plasmids-among-colistin-resistant-salmonella-strains-from-humans-and-food-producing-animals-taiwan
#15
Chien-Shun Chiou, Ying-Tsong Chen, You-Wun Wang, Yen-Yi Liu, Hung-Chih Kuo, Yeuh-Hua Tu, Ann-Chi Lin, Ying-Shu Liao, Yu-Ping Hong
We detected the colistin-resistance gene mcr-1 in four Salmonella serovars isolated from humans and animals with diarrhea. The resistance gene was carried on different plasmids. One mcr-1-carrying conjugative plasmid, a variant of pHNSHP45, was disseminated among Salmonella isolates recovered from humans, pigs, and chickens.
April 17, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28416544/deciphering-heteroresistance-to-colistin-in-a-klebsiella-pneumoniae-isolate-from-marseille-france
#16
Lucie Bardet, Sophie Baron, Thongpan Leangapichart, Liliane Okdah, Seydina M Diene, Jean-Marc Rolain
Here, we report the description of a colistin-heteroresistant Klebsiella pneumoniae fortuitously isolated from the stool sample of a patient with suspicion of tuberculosis in public hospital of Marseille, France. In the colistin-resistant subpopulation, a mutation in the mgrB gene leading to a premature Stop-codon was found, and the hypermucoviscous phenotype was lost. Susceptibility to other antibiotics remained unchanged. To our knowledge, this is the first identification of such a colistin-heteroresistant Klebsiella pneumoniae isolate in France...
April 17, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28416543/potential-toxicity-of-polymyxins-in-human-lung-epithelial-cells
#17
Maizbha U Ahmed, Tony Velkov, Yu-Wei Lin, Bo Yun, Cameron J Nowell, Fanfan Zhou, Qi Tony Zhou, Kim Chan, Mohammad A K Azad, Jian Li
Inhaled polymyxins are of considerable utility to achieve optimal exposure in the respiratory tract for the treatment of lung infections caused by multidrug-resistant Gram-negative pathogens. Current inhaled polymyxin therapy is empirical and often high doses are used which may lead to potential pulmonary adverse effects. This study aimed to investigate the effect of polymyxins on human lung epithelial cells (A549). Viability of A549 cells was examined after treatment with polymyxins using flow cytometry. Activation of caspase-3, -8, -9, expression of Fas ligand (FasL), loss of mitochondrial membrane potential and mitochondrial oxidative stress induced by polymyxin B was evaluated...
April 17, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28410932/outcome-analysis-of-colistin-treated-burn-center-patients
#18
Rachel E Wilkinson, David M Hill, William L Hickerson
OBJECTIVES: Intravenous colistimethate sodium (CMS) use in burn center patients is increasing due to the emergence of multidrug-resistant gram-negative bacteria. However, optimal dosing strategies and factors that may contribute to treatment failure are limited. The purpose of this study was to determine factors that may contribute to treatment failure in colistin-treated burn center patients. METHODS: This retrospective, observational study included burn center patients that received ≥48h of intravenous CMS between June 1, 2009 and June 30, 2014...
April 11, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28410511/evaluation-of-intraventricular-colistin-utilization-a-case-series
#19
Brian Gilbert, Christopher Morrison
PURPOSE: Multi-drug resistant organisms (MDROs) are an increasing concern in health systems. Pathogens such as Pseudomonas aeruginosa, Acinetobacter baumanii, and carbapenamase-producing Enterobacteriaceae hold highest mortality rates especially when the central nervous system is involved. When MDROs are cultured treatment options are limited and reliance on medications such as colistin is becoming more prevalent. Penetration of these therapies into the central nervous system is concerning therefore local administration is a potential concomitant therapy...
April 7, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28409502/the-role-of-wildlife-wild-birds-in-the-global-transmission-of-antimicrobial-resistance-genes
#20
REVIEW
Jing Wang, Zhen-Bao Ma, Zhen-Ling Zeng, Xue-Wen Yang, Ying Huang, Jian-Hua Liu
Antimicrobial resistance is an urgent global health challenge in human and veterinary medicine. Wild animals are not directly exposed to clinically relevant antibiotics; however, antibacterial resistance in wild animals has been increasingly reported worldwide in parallel to the situation in human and veterinary medicine. This underlies the complexity of bacterial resistance in wild animals and the possible interspecies transmission between humans, domestic animals, the environment, and wildlife. This review summarizes the current data on expanded-spectrum β-lactamase (ESBL), AmpC β-lactamase, carbapenemase, and colistin resistance genes in Enterobacteriaceae isolates of wildlife origin...
March 18, 2017: Zoological Research
keyword
keyword
1811
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"