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Paraoxonase

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https://www.readbyqxmd.com/read/29050675/comparison-of-serum-acetyl-hydrolase-paf-ah-and-paraoxonase-1-pon1-values-between-prostate-cancer-patients-and-a-control-group
#1
Erdal Benli, Ahmet Bayrak, Abdullah Cirakoglu, Tulin Bayrak, Tevfik Noyan
The aim of the study was to measure platelet-activating factor acetyl hydrolase (PAF-AH) and paraoxonase (PON1) enzyme activity levels in patients with high Psa values to compare with healthy peers and also to determine the efficacy of these parameters in predicting pathologic results of patients with high Psa values. This study included 66 patients with Psa value > 4 ng/dl (Group 1) and 44 patients with Psa <4 ng/dl (Group 2) for a total of 110 patients. Parameters measured in serum of PON1, PAF-AH, and MDA were compared between the groups...
November 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/29049204/the-genetic-association-between-pon1-polymorphisms-and-osteonecrosis-of-femoral-head-a-case-control-study
#2
Jian-Mei Li, Yi Li, Lu Wang
The purpose of this study was to investigate the relationship between Paraoxonase-1 (PON1) gene rs662, rs854555 polymorphisms and osteonecrosis of the femoral head (ONFH) in Han population, northern China.Polymerase chain reaction-restriction fragment length polymorphism was used to determine genotypes of PON1 polymorphisms in 84 patients with ONFH and 96 healthy persons. χ test was used to compare distribution differences of genotype, allele, and haplotype between the case and control groups. The odds ratio (OR) and 95% confidence interval (CI) were calculated to reveal the effects of PON1 polymorphisms on risk of ONFH, and the results were adjusted using logistic regression analysis...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29049176/correlation-of-pon1-polymorphisms-with-ankylosing-spondylitis-susceptibility-a-case-control-study-in-chinese-han-population
#3
Haitao Xu, Yiming Qu
Paraoxonase 1 (PON1) modulates the oxidative stress and inflammatory response, thus, it might relate to the risk of ankylosing spondylitis (AS). The aim of present study was to discover the correlation of PON1 polymorphisms (rs662 and rs854560) with PON1 activity and AS risk.Around 128 AS patients and 146 healthy controls were recruited in this case-control study. PON1 polymorphisms were genotyped by direct sequencing. Serum PON1 activity was detected and compared by nonparametric test in different genotypes of PON1 polymorphisms...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29049133/hdl-cholesterol-efflux-is-impaired-in-older-patients-with-early-sepsis-a-subanalysis-of-a-prospective-pilot-study
#4
Faheem W Guirgis, Christiaan Leeuwenburgh, Victor Grijalva, Jennifer Bowman, Colleen Kalynych, Lyle Moldawer, Frederick A Moore, Srinivasa T Reddy
BACKGROUND: Proper functioning of high density lipoprotein (HDL) is necessary for protection against sepsis. However, previous work has demonstrated that HDL becomes oxidized and dysfunctional (Dys-HDL) during sepsis. Older (age > 65 years) patients are at particularly high risk of sepsis and poor outcomes from sepsis. STUDY OBJECTIVE: To compare functional properties of HDL (cholesterol efflux capacity and paraoxonase enzyme 1 (PON-1) activity) and Dys-HDL between older (age > 65 years) sepsis patients and older healthy volunteers...
October 18, 2017: Shock
https://www.readbyqxmd.com/read/29044294/serum-levels-of-anti-pon1-and-anti-hdl-antibodies-as-potential-biomarkers-of-premature-atherosclerosis-in-systemic-lupus-erythematosus
#5
Patricia López, Javier Rodríguez-Carrio, Aleida Martínez-Zapico, Ángel I Pérez-Álvarez, Raquel López-Mejías, Lorena Benavente, Lourdes Mozo Mozo, Luis Caminal-Montero, Miguel A González-Gay, Ana Suárez
The present study aimed to evaluate the possible role of immunoglobulin G (IgG) antibodies against high-density lipoproteins (HDL) and paraoxonase 1 (PON1) as possible biomarkers of cardiovascular disease (CVD) in systemic lupus erythematosus (SLE). To this end, levels of these autoantibodies, PON1 activity and total antioxidant capacity were quantified in serum samples from 198 SLE patients, 100 healthy controls (HC) and 42 non-autoimmune individuals with traditional cardiovascular risk factors. PON1 rs662 polymorphism was analysed in a subgroup of patients and controls...
October 10, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29035403/-polymorphism-of-genes-encoding-proteins-of-dna-repair-vs-occupational-and-environmental-exposure-to-lead-arsenic-and-pesticides
#6
REVIEW
Karol Bukowski, Katarzyna Woźniak
Genetic polymorphism is associated with the occurrence of at least 2 different alleles in the locus with a frequency higher than 1% in the population. Among polymorphisms we can find single nucleotide polymorphism (SNP) and polymorphism of variable number of tandem repeats. The presence of certain polymorphisms in genes encoding DNA repair enzymes is associated with the speed and efficiency of DNA repair and can protect or expose humans to the effects provoked by xenobiotics. Chemicals, such as lead, arsenic pesticides are considered to exhibit strong toxicity...
October 12, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/29034644/the-effect-of-eicosapentaenoic-acid-on-the-serum-levels-and-enzymatic-activity-of-paraoxonase-1-in-the-patients-with-type-2-diabetes-mellitus
#7
Mohammad Hassan Golzari, Saeed Hosseini, Fariba Koohdani, Ali-Akbar Saboor Yaraghi, Mohammad Hassan Javanbakht, Niyaz Mohammadzadeh-Honarvar, Mahmoud Djalali
Paraoxonase 1 is known as one of the most important ant oxidative enzymes associated with HDL-c, and because of its antioxidant and antiinflammatory activities. EPA has the antioxidant, anti inflammatory, antithrombogenic, and antiarteriosclerotic properties. Therefore, we investigated the effect of EPA supplementation on the serum levels and activity of PON1 in type 2 diabetic patients. This study was designed as a randomized, double-blind, and placebo-controlled clinical trial. Thirty-six patients with type 2 diabetes were given written; informed consent randomly was classified into 2 groups...
August 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29025405/the-anti-inflammatory-function-of-hdl-is-impaired-in-type-2-diabetes-role-of-hyperglycemia-paraoxonase-1-and-low-grade-inflammation
#8
Sanam Ebtehaj, Eke G Gruppen, Mojtaba Parvizi, Uwe J F Tietge, Robin P F Dullaart
BACKGROUND: Functional properties of high density lipoproteins (HDL) are increasingly recognized to play a physiological role in atheroprotection. Type 2 diabetes mellitus (T2DM) is characterized by low HDL cholesterol, but the effect of chronic hyperglycemia on the anti-inflammatory capacity of HDL, a metric of HDL function, is unclear. Therefore, the aim of the present study was to establish the impact of T2DM on the HDL anti-inflammatory capacity, taking paraoxonase-1 (PON-1) activity and low grade inflammation into account...
October 12, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29019104/the-effect-of-boron-on-some-biochemical-parameters-in-experimental-diabetic-rats
#9
Selcen Cakir, Meryem Eren, Meryem Senturk, Zeynep Soyer Sarica
In this study, we evaluated the effect of boron (B) as boric acid (BA) on body weight (b.w.); blood glucose; plasma insulin; lipase and paraoxonase (PON1) activities; and serum triglyceride, total cholesterol, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, lipid peroxidation (MDA), and total antioxidant capacity (TAC) in streptozotocin (STZ)-induced experimental diabetes in rats. Sixty Wistar albino rats (200-250 g) were divided into six groups of ten. The groups received the following treatment: group 1, control group; group 2, 50 mg/kg (b...
October 10, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28991135/activity-of-paraoxonase-arylesterase-and-butyrylcholinesterase-in-peripheral-blood-of-gulf-war-era-veterans-with-neurologic-symptom-complexes-or-post-traumatic-stress-disorder
#10
David D Haines, John E Ottenweller, Benjamin F Dickens, Fadia Fouad Mahmoud, Paul H Levine
OBJECTIVE: Two groups of Gulf War era veterans, one exhibiting blurred vision, balance problems/dizziness, tremors/shaking, and speech difficulty and a second group with post-traumatic stress disorder (PTSD), but not the neurologic syndrome, were assessed for organophosphate-detoxifying enzyme paraoxonase/arylesterase (PON1) and its Q/R isoforms, butyrylcholinesterase (BuChE) and its U/A isoforms and cytokines. METHODS: Defibrinated peripheral blood was evaluated for enzymes and cytokines...
October 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28988620/collapsing-the-metabolic-pon2zi-scheme-in-pancreatic-ductal-adenocarcinoma
#11
Matyas Abel Tsegaye, Zachary T Schafer
A hallmark of pancreatic ductal adenocarcinoma cancer (PDAC) cells is metabolic reprogramming that facilitates tumor progression. In a recent paper published in Molecular Cell, Nagarajan et al. discover that paraoxonase (PON)2 stimulates glucose transporter (GLUT)1-mediated glucose uptake, prevents AMP-activated protein kinase (AMPK)-mediated anoikis, and consequently promotes PDAC development and metastasis.
October 4, 2017: Trends in Cell Biology
https://www.readbyqxmd.com/read/28982861/liver-x-receptor-lxr-regulated-genes-of-cholesterol-trafficking-and-breast-cancer-severity
#12
COMPARATIVE STUDY
Christine Bobin-Dubigeon, Anaïs Chauvin, Victoire Brillaud-Meflah, Florence Boiffard, Marie-Pierre Joalland, Jean-Marie Bard
BACKGROUND: Liver X receptor [LXR; nuclear receptor subfamily 1, group H, member 2 (NR1H2, alias LXRB)] can inhibit proliferation and induce apoptosis of cancer cells. Its relationship with disease severity is not known. MATERIALS AND METHODS: Expression of LXRB, ATP binding cassette subfamily A member 1 (ABCA1), ATP binding cassette subfamily G member 1 (ABCG1), apolipoprotein E (APOE) and paraoxonase 2 (PON2) were determined in 69 breast tumors and were related to clinical stages of the disease and tumor characteristics, as well as time to recurrence...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28966080/cord-and-maternal-sera-from-small-neonates-share-dysfunctional-lipoproteins-with-proatherogenic-properties-evidence-for-barker-s-hypothesis
#13
Seong-Min Kim, Seung Mi Lee, Suk-Jeong Kim, Byoung Jae Kim, Sue Shin, Jae-Ryong Kim, Kyung-Hyun Cho
BACKGROUND: Fetal growth restriction (GR) is associated with perinatal mortality and subsequent metabolic disorders in adulthood. Until now, there is little information regarding changes in the properties of lipoproteins from growth-restricted fetuses and their maternal sera. OBJECTIVE: To identify unique lipoprotein biomarkers for fetal GR in maternal and cord sera from small neonates, we analyzed lipoprotein compositions and functions. METHODS: Lipoprotein compositions and functions were compared between cord blood and maternal blood among small for gestational age neonates (SGA; n = 15, 2589 ± 50 g) and appropriate for gestational age neonates (AGA; n = 15) in Korea...
September 14, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28963619/the-effect-of-vitamin-e-l-carnitine-and-ginger-on-production-traits-immune-response-and-antioxidant-status-in-two-broiler-strains-exposed-to-chronic-heat-stress
#14
Zia Ur Rehman, Naila Chand, Rifat Ullah Khan
The present study was designed to find the effect of natural and synthetic antioxidants on the performance of two broiler strains under high ambient temperature. A total of 320 day-old chicks of Hubbard and Cobb were reared for a period for 21 days under the same nutritional and management systems. On day 21 onward, one subgroup was kept as control while other subgroups were provided with vitamin E (250 mg/kg), ginger (2 g/kg), and L-carnitine (500 mg/kg) in basal diets. Body weight and feed conversion ratio (FCR) were significantly (P < 0...
September 30, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28962559/neuro-protective-effect-of-rutin-against-cisplatin-induced-neurotoxic-rat-model
#15
Mashal M Almutairi, Wael A Alanazi, Musaad A Alshammari, Moureq Rashed Alotaibi, Ali R Alhoshani, Salim Salah Al-Rejaie, Mohamed M Hafez, Othman A Al-Shabanah
BACKGROUND: Cisplatin is widely used chemotherapeutic agent for cancer treatment with limited uses due to its neurotoxic side effect. The aim of this study was to determine the potential preventive effects of rutin on the brain of cisplatin- neurotoxic rat model. METHODS: Forty rats were divided into four groups. Group-1 (control group) was intra-peritoneal (IP) injected with 2.5 ml/kg saline. Group-2 (rutin group) was orally administrated 30 mg/kg rutin dissolved in water for 14 days...
September 29, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28958565/association-between-thyroid-function-and-lipid-profiles-apolipoproteins-and-high-density-lipoprotein-function
#16
Kyong Yeun Jung, Hwa Young Ahn, Sun Kyoung Han, Young Joo Park, Bo Youn Cho, Min Kyong Moon
BACKGROUND: Thyroid hormone regulates lipid metabolism. In particular, it has been reported to regulate plasma high-density lipoprotein cholesterol (HDL-C) levels and the activity of molecules involved in HDL metabolism. OBJECTIVE: We investigated changes in the concentrations of lipids and apolipoproteins and in the function of HDL according to acute dynamic changes in thyroid function. METHODS: Concentrations of plasma lipids and apolipoproteins, paraoxonase-1 activity, and cholesterol efflux were measured in 27 patients with differentiated thyroid carcinoma who underwent total thyroidectomy and radioactive iodine (RAI) treatment, at 3 distinct times: After surgery (baseline subclinical hyperthyroid state), on the day of undergoing RAI treatment (overt hypothyroid state), and 3 months post-RAI treatment (subclinical hyperthyroid state)...
September 4, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28954597/a-meta-analysis-on-the-relationship-of-the-pon-genes-and-alzheimer-disease
#17
Yi Nie, Danyang Luo, Min Yang, Yi Wang, Li Xiong, Li Gao, Yan Liu, Hua Liu
AIM: This study aimed to evaluate the association of the paraoxonase (PON) gene variants and Alzheimer disease (AD) using meta-analysis. METHODS: Relevant studies were identified by searching English and Chinese databases extensively. Allele and genotype frequencies for each included study were extracted. Newcastle-Ottawa Scale (NOS) was employed to assess the quality of included studies. The odds ratio (OR) with 95% confidence interval (95% CI) was calculated using a random-effects or fixed-effects model...
January 1, 2017: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/28942826/nitric-oxide-synthase-inhibitors-protect-against-brain-and-liver-damage-caused-by-acute-malathion-intoxication
#18
Omar M E Abdel-Salam, Eman R Youness, Nadia A Mohammed, Noha N Yassen, Yasser A Khadrawy, Safinaz Ebrahim El-Toukhy, Amany A Sleem
OBJECTIVE: To investigate the effect of N(G)-nitro-l-arginine methyl ester (l-NAME), a non-selective nitric oxide synthase (NOS) inhibitor, and 7-nitroindazole (7-NI), a selective neuronal NOS inhibitor, on oxidative stress and tissue damage in brain and liver and on DNA damage of peripheral blood lymphocytes in malathion intoxicated rats. METHODS: Malathion (150 mg/kg) was given intraperitoneally (i.p.) along with l-NAME or 7-NI (10 or 20 mg/kg, i.p.) and rats were euthanized 4 h later...
August 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28940111/hyperuricemia-is-associated-with-increased-apo-ai-fractional-catabolic-rates-and-dysfunctional-hdl-in-new-zealand-rabbits
#19
Miriam Martínez-Ramírez, Cristóbal Flores-Castillo, L Gabriela Sánchez-Lozada, Rocío Bautista-Pérez, Elizabeth Carreón-Torres, José Manuel Fragoso, José Manuel Rodriguez-Pérez, Fernando E García-Arroyo, Victoria López-Olmos, María Luna-Luna, Gilberto Vargas-Alarcón, Martha Franco, Oscar Pérez-Méndez
The potential cause-effect relationship between uric acid plasma concentrations and HDL functionality remains elusive. Therefore, this study aimed to explore the effect of oxonic acid (OA)-induced hyperuricemia on the HDL size distribution, lipid content of HDL subclasses, and apo AI turnover, as well as HDL functionality in New Zealand white rabbits. Experimental animals received OA 750 mg/kg/day by oral gavage during 21 days. The HDL-apo AI fractional catabolic rate (FCR) was determined by exogenous labeling with (125)I, and HDL subclasses were determined by sequential ultracentrifugation and PAGE...
September 22, 2017: Lipids
https://www.readbyqxmd.com/read/28932603/the-protective-effect-of-naringenin-oxime-on-cisplatin-induced-toxicity-in-rats
#20
Ismail Koyuncu, Abdurrahim Kocyigit, Ataman Gonel, Erkan Arslan, Mustafa Durgun
The aim of this study is to examine the protective effect of naringenin-oxime (NOX) on cisplatin-induced major organ toxicity and DNA damage in rats. Thirty-five male Wistar albino rats were equally split into five groups as follows: control (i.p., 0.1 ml of saline), Cis administration (i.p., 7 mg/kg b.w.), NOX treatment (i.p., 20 mg/kg b.w., daily for ten days), Cis + NOX20, and Cis + NOX40 combination (i.p., 20 and 40 mg/kg b.w., daily for ten days). Serum and peripheral blood mononuclear leukocytes (PBMC) were obtained from blood...
2017: Biochemistry Research International
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