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Paraoxonase

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https://www.readbyqxmd.com/read/29441810/pon2-and-pparg-polymorphisms-as-biomarkers-of-risk-for-coronary-heart-disease
#1
Thelma Beatriz González-Castro, Carlos Alfonso Tovilla-Zárate, Isela Esther Juárez-Rojop, Yazmín Hernández-Díaz, María Lilia López-Narváez, Candelario Rodríguez-Pérez, Yahaira Karina González-Hernández, Miguel Ángel Ramos-Méndez
AIM: Investigate the correlation between paraoxonase 2 (PON2) Ser311Cys polymorphism as well as the peroxisome proliferator-activated receptor gamma (PPARG) His477His polymorphism and the susceptibility to development of coronary heart diseases (CHD) through a meta-analysis. METHODS: Odds ratio and the corresponding 95% CI were used to assess the results. We included 7476 CHD patients and 8504 healthy controls. All the statistical analyses were performed by Comprehensive Meta-Analysis software (CMA, version 2...
February 14, 2018: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29439952/paraoxonase-2-regulates-coagulation-activation-through-endothelial-tissue-factor
#2
Julia Ebert, Petra Wilgenbus, John F Teiber, Kerstin Jurk, Kathrin Schwierczek, Mareike Döhrmann, Ning Xia, Huige Li, Lisa Spiecker, Wolfram Ruf, Sven Horke
Oxidative stress and inflammation of the vessel wall contribute to pro-thrombotic states. The anti-oxidative protein paraoxonase-2 (PON2) shows reduced expression in human atherosclerotic plaques and endothelial cells in particular. Supporting a direct role for Pon2 in cardiovascular diseases, Pon2 -deficiency in mice promotes atherogenesis through incompletely understood mechanisms. Here, we show that deregulated redox regulation in Pon2-deficiency causes vascular inflammation and abnormalities in blood coagulation...
February 9, 2018: Blood
https://www.readbyqxmd.com/read/29439274/relation-of-paraoxonase-1-activity-with-biochemical-variables-brachial-artery-intima-media-thickness-in-patients-with-diabetes-with-or-without-obesity
#3
Pinar Karakaya, Bahar Ozdemir, Meral Mert, Yildiz Okuturlar
AIM: The sodium-sparing effect of insulin leads to increase in total sodium pool of the body which is a chronic stimulus for atrial natriuretic peptide (ANP). In our study we aimed to determine the relationship between ANP and microvascular complications of diabetes. METHODS: 60 patients, 30-70 years old, with the diagnosis of type 2 diabetes mellitus (DM) are enrolled into the study. Patients with a chronic disease other than DM are excluded. Blood samples for routine biochemical tests are taken after at least 12 h fasting at 8-9 am...
February 14, 2018: Obesity Facts
https://www.readbyqxmd.com/read/29412239/association-of-multiple-genetic-variants-with-the-extension-and-severity-of-coronary-artery-disease
#4
Simone Cristina Pinto Matheus Fischer, Simone Pires Pinto, Lívia Campos do Amaral Silva Lins, Henrique Tria Bianco, Carlos Manoel de Castro Monteiro, Luiz Fernando Muniz Pinheiro, Francisco Antonio Helfenstein Fonseca, Maria Cristina de Oliveira Izar
BACKGROUND: Metabolic syndrome (MS) is a condition that, when associated with ischemic heart disease and cardiovascular events, can be influenced by genetic variants and determine more severe coronary atherosclerosis. OBJECTIVES: To examine the contribution of genetic polymorphisms to the extension and severity of coronary disease in subjects with MS and recent acute coronary syndrome (ACS). METHODS: Patients (n = 116, 68% males) aged 56 (9) years, with criteria for MS, were prospectively enrolled to the study during the hospitalization period after an ACS...
February 1, 2018: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/29411726/association-between-the-oxidative-status-vitamin-d-levels-and-respiratory-function-in-asthmatic-children
#5
M Igde, P Baran, B G Oksuz, S Topcuoglu, G Karatekin
AIM: We studied the relationship between plasma concentrations of oxidative system markers, vitamin D, and respiratory functions in children with asthma. MATERIALS AND METHODS: Ninety one children aged 6-17 years with stable asthma seen in the clinic had the serum concentrations of oxidative system markers [total antioxidant capacity (TAC), total oxidative status (TOS), paraoxonase-1 activity (PON-1), and 25-hydroxyvitamin D3] and respiratory functions were measured...
January 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29411531/aspirin-and-clopidogrel-high-on-treatment-platelet-reactivity-and-genetic-predictors-in-peripheral-arterial-disease
#6
Khung-Keong Yeo, Ehrin J Armstrong, Javier E López, Debbie C Chen, Gregory G Westin, Chin-Shang Li, David Anderson, Amy Hua, Anil Singapuri, Ezra A Amsterdam, Nipavan Chiamvimonvat, John R Laird
OBJECTIVES: Our aims were to examine the prevalence and genetic predictors of aspirin and clopidogrel high on-treatment platelet reactivity (HoTPR), and associated adverse cardiovascular outcomes in patients with peripheral arterial disease (PAD). BACKGROUND: The association of aspirin and clopidogrel HoTPR with outcomes in PAD remains unclear. METHODS: This is a prospective cohort study of patients with angiographically documented PAD involving carotid and lower extremity arteries...
February 7, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29409844/association-of-paraoxonase-1-gene-polymorphisms-with-insulin-resistance-in-south-indian-population
#7
Panneerselvam Gomathi, Anandi Chandramouli Iyer, Ponniah Senthil Murugan, Sundaresan Sasikumar, Nancy Bright Arul Joseph Raj, Divya Ganesan, Sivagnanam Nallaperumal, Maruthamuthu Murugan, Govindan Sadasivam Selvam
BACKGROUND AND AIM: Insulin resistance plays a crucial role in the pathogenesis of type 2 diabetes and cardiovascular diseases. Recently, paraoxonase-1(PON1) is reported to have an ability to reduce insulin resistance by promoting glucose transporter-4 (GLUT-4) expression in vitro. Single nucleotide polymorphism (SNP) in PON1 is associated with variability in enzyme activity and concentration. Based on this we aimed to investigate the association of PON1 (Q192R and L55M) polymorphisms with the risk of developing insulin resistance in adult South Indian population...
January 31, 2018: Gene
https://www.readbyqxmd.com/read/29405729/the-effects-of-resveratrol-on-hepatic-oxidative-stress-in-metabolic-syndrome-model-induced-by-high-fructose-diet
#8
C Yilmaz Demirtas, F S Bircan, O T Pasaoglu, N Turkozkan
BACKGROUND: The purpose of this study was to evaluate probable protective effects of resveratrol treatment on hepatic oxidative events in a rat model of metabolic syndrome (MetS). METHODS: Thirty-two male adult rats were randomly divided into 4 groups: control, fructose, resveratrol, and fructose plus resveratrol. To induce MetS, fructose solution (20 % in drinking water) was used. Resveratrol (10 mg/kg/day) was given by oral gavage. All treatments were given for 8 weeks...
2018: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29404699/paraoxonases-metabolic-role-and-pharmacological-projection
#9
REVIEW
Carlos Moya, Salvador Máñez
Atherosclerosis is one of the leading causes of death in Western countries, with high-density lipoproteins (HDL) playing an important protective role due to their ability to inhibit oxidation of low-density lipoproteins (LDL), thus relieving vascular subendothelial damage. One of the proteins constituting HDL particles is paraoxonase-1 (PON1), an enzyme able to hydrolyze aryl esters, lactones, and organophosphates. Other closely related paraoxonases are designated as PON2, which is a protein localized inside many different kinds of cells, and PON3, not only present in HDL but also in mitochondria and endoplasmic reticulum, as well...
February 6, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29398508/lipoprotein-apheresis-affects-lipoprotein-particle-subclasses-more-efficiently-compared-to-the-pcsk9-inhibitor-evolocumab-a-pilot-study
#10
Knut Tore Lappegård, Christian Abendstein Kjellmo, Stefan Ljunggren, Karin Cederbrant, Maritha Marcusson-Ståhl, Monica Mathisen, Helen Karlsson, Anders Hovland
Lipoprotein apheresis and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors are last therapeutic resorts in patients with familial hypercholesterolemia (FH). We explored changes in lipoprotein subclasses and high-density lipoprotein (HDL) function when changing treatment from lipoprotein apheresis to PCSK9 inhibition. We measured the levels of low-density lipoprotein (LDL) and HDL particle subclasses, serum amyloid A1 (SAA1), paraoxonase-1 (PON1) activity and cholesterol efflux capacity (CEC) in three heterozygous FH patients...
January 4, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29397664/genotype-phenotype-analysis-of-paraoxonase-1-in-schizophrenic-patients-treated-with-atypical-antipsychotics
#11
Denis Pavăl, Bogdan Nemeș, Răzvan L Rusu, Eleonora Dronca
Objective: Recent studies suggest a possible involvement of low paraoxonase 1 (PON1) enzyme activities in the association between schizophrenia, treatment with atypical antipsychotics and increased cardiovascular (CVD) risk. In the present study, we aimed at investigating the PON1 status in a group of schizophrenic patients treated with either olanzapine or other antipsychotic, as compared to a group of healthy control participants. Methods: We assessed the arylesterase (AREase) and paraoxonase (POase) activities of PON1, as well as three common polymorphisms of PON1 gene (Q192R, L55M, -108C>T)...
February 28, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29395491/epistasis-analysis-of-metabolic-genes-polymorphisms-associated-with-ischemic-heart-disease-in-yucatan
#12
Igrid García-González, Roger Iván López-Díaz, José Reyes Canché-Pech, Alberto de Jesús Solís-Cárdenas, Jorge A Flores-Ocampo, Renán Mendoza-Alcocer, Luis Fernando Herrera-Sánchez, Marco Antonio Jiménez-Rico, Adrián Alejandro Ceballos-López, María E López-Novelo
OBJECTIVE: Epistasis is a type of genetic interaction that could explain much of the phenotypic variability of complex diseases. In this work, the effect of epistasis of metabolic genes and cardiovascular risk on the susceptibility to the development of ischemic heart disease in Yucatan was determined. METHODS: Case-control study in 79 Yucatecan patients with ischemic heart disease and 101 healthy controls matched by age and origin with cases. The polymorphisms -108CT, Q192R, L55M (paraoxonase 1; PON1), C677T, A1298C (methylenetetrahydrofolate reductase; MTHFR), and the presence/absence of the glutathione S-transferase T1 (GSTT1) gene were genotyped...
January 28, 2018: Clínica e Investigación en Arteriosclerosis
https://www.readbyqxmd.com/read/29394290/impact-of-the-24-h-ultramarathon-race-on-homocysteine-oxidized-low-density-lipoprotein-and-paraoxonase-1-levels-in-professional-runners
#13
Serena Benedetti, Simona Catalani, Federica Peda, Francesca Luchetti, Roberto Citarella, Serafina Battistelli
The impact of the 24-h ultramarathon race on homocysteine (Hcy) and oxidized low-density lipoprotein (oxLDL) levels, two well-recognized cardiovascular risk factors, has not been deeply investigated. Similarly, no information exists on paraoxonase 1 (PON1), an antioxidant enzyme associated with high-density lipoproteins, which may detoxify oxLDL and Hcy-thiolactone, hence preventing their proatherogenic action. Taking this into account, a competitive 24-h ultramarathon race was organized in Reggio-Emilia (Italy) recruiting professional runners (n = 14) from the Italian Ultramarathon and Trail Association...
2018: PloS One
https://www.readbyqxmd.com/read/29393817/relationship-between-paraoxonase-1-and-butyrylcholinesterase-activities-and-nutritional-status-in-mexican-children
#14
Rocío Ramírez-Jiménez, María Fernanda Martínez-Salazar, Damianys Almenares-López, Leticia Yáñez-Estrada, Antonio Monroy-Noyola
BACKGROUND: The enzymes butyrylcholinesterase (BuChE) and paraoxonase-1 (PON1) are the primary bioscavenging enzymes in serum and exhibit antioxidant and anti-inflammatory activities. PON1 has been associated with diseases caused by high oxidative stress, whereas BuChE appears to be involved in the pathophysiology of the metabolic syndrome and related disorders. It has been suggested that children from rural communities in Mexico may have a predisposition to develop obesity or type 2 diabetes during adolescence or adulthood...
February 2, 2018: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29392808/selected-serum-oxidative-stress-biomarkers-in-dogs-with-non-food-induced-and-food-induced-atopic-dermatitis
#15
Ramón M Almela, Camila P Rubio, José J Cerón, Agustina Ansón, Alexander Tichy, Ursula Mayer
BACKGROUND: Oxidative stress (OS) has been shown to be involved in the pathogenesis of human and canine atopic dermatitis (AD) through several distinct mechanisms. Selected serum biomarkers of OS (sbOS) have been validated in normal dogs and studied in several canine diseases. To the best of the authors' knowledge, the sbOS evaluated in this study have not previously been described in canine AD. HYPOTHESIS/OBJECTIVES: The aims of the study were to evaluate a panel of sbOS in dogs with food-induced (FIAD) and non-food-induced (NFIAD) AD: cupric reducing antioxidant capacity (CUPRAC), ferrous oxidation-xylenol orange (FOX), ferric reducing ability of the plasma (FRAP), paraoxonase-1 (PON1), trolox equivalent antioxidant capacity (TEAC) and serum total thiol (THIOL)...
February 1, 2018: Veterinary Dermatology
https://www.readbyqxmd.com/read/29392069/serum-oxidative-stress-levels-in-patients-with-nasal-septal-deviation
#16
Adnan Ekinci, Duran Karataş, Abdurrahman Yetiş, Emre Demir, Müge Özcan
Objective: Comparison of the total oxidant status (TOS), total antioxidant status (TAS) and paraoxonase (PON1) serum levels in patients with nasal septum deviation (NSD) and healthy subjects. Methods: The TAS, TOS, and PON1 serum levels of 47 patients with NSD (mean age 35.3) and 50 healthy subjects (mean age 37.8) were compared in this study. Results: We found significantly higher TAS levels in the control group (p<0.001). The mean TAS value was 1...
September 2017: Turkish Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/29385837/verification-of-a-proteomic-biomarker-panel-to-diagnose-minor-stroke-and-transient-ischaemic-attack-phase-1-of-spectra-a-large-scale-translational-study
#17
Andrew M Penn, Maximilian B Bibok, Viera K Saly, Shelagh B Coutts, Mary L Lesperance, Robert F Balshaw, Kristine Votova, Nicole S Croteau, Anurag Trivedi, Angela M Jackson, Janka Hegedus, Evgenia Klourfeld, Amy Y X Yu, Charlotte Zerna, Christoph H Borchers
OBJECTIVE: To derive a plasma biomarker protein panel from a list of 141 candidate proteins which can differentiate transient ischaemic attack (TIA)/minor stroke from non-cerebrovascular ('mimic') conditions in emergency department (ED) settings. DESIGN: Prospective clinical study (#NCT03050099) with up to three timed blood draws no more than 36 hours following symptom onset. Plasma samples analysed by multiple reaction monitoring-mass spectrometry (MRM-MS). PARTICIPANTS: 545 participants suspected of TIA enrolled in the EDs of two urban medical centres...
February 1, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29378362/inhibitory-effects-of-an-orally-active-thromboxane-a2-receptor-antagonist-nstpbp5185-on-atherosclerosis-in-apoe-deficient-mice
#18
Shiu-Wen Huang, Jin-Cherng Lien, Sheng-Chu Kuo, Tur-Fu Huang
Thromboxane A2 (TXA2) activation of TP receptor has been shown contributing to the progression and acute complications of atherosclerosis including endothelial dysfunction, platelet hyperactivity and inflammation. Growing evidence suggests that TP receptor may represent as a therapeutic target in atherosclerosis and related cardiovascular diseases. We investigated whether nstpbp5185, an orally active TP receptor antagonist, exhibits protective effects against atherosclerotic progression. Nstpbp5185 and aspirin were orally administered daily for 12 weeks in high-cholesterol-fed ApoE-deficient mice to examine their anti-atherosclerosis effects...
February 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29368426/serum-endocan-levels-are-associated-with-paraoxonase-1-concentration-in-patients-with-chronic-kidney-disease
#19
Elisabeth Samouilidou, Eirini Bountou, Fotini Papandroulaki, Manolis Papamanolis, Dimitris Papakostas, Eirini Grapsa
Endocan is a soluble proteoglycan released by the vascular endothelium. The increase of its serum levels is associated with inflammation, endothelial dysfunction and cardiovascular events in patients with chronic kidney disease (CKD). We studied the association of serum endocan with the lipid profile of 105 CKD patients with dyslipidemia, divided in two groups, non-dialyzed (CKD, N = 57) and hemodialysis (HD, N = 48) in comparison with 30 normal controls (NC). We also analyzed endocan in relation with the concentration of two serum HDL-linked members of the paraoxonase (PON) family, PON1 and PON3, which have been previously found to have antiatherogenic properties...
January 25, 2018: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/29365849/dysfunctional-hdl-characterized-by-decreased-paraoxonase-1-and-increased-apolipoproteins-aii-ciii-and-myeloperoxidase-levels-discriminate-between-acute-coronary-syndrome-and-stable-cad-patients
#20
Mihaela Carnuta, Camelia S Stancu, Gabriela M Sanda, Laura Toma, Loredan S Niculescu, Mariana Deleanu, Andreea C Popescu, Mihaela R Popescu, Adelina Vlad, Doina R Dimulescu, Maya Simionescu, Anca V Sima
No abstract text is available yet for this article.
August 2017: Atherosclerosis
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