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Paraoxonase

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https://www.readbyqxmd.com/read/29237378/substrates-for-paraoxonase
#1
Xiaojing Mu, Xiaoqi Yi, Shangyou Xiao, Chengshan Wang, Gang Chen, Yan Li
BACKGROUND: Paraoxonase (PON) is a family of calcium-dependent hydrolases which is related to many diseases. Elucidation of PON physiological roles, active center and all applications in medical fields are dependent of its substrates. OBJECTIVE: The reports about PON substrates scattered in a long span of period are collected to afford clue for drug design, diagnosis of PON status and other academic purposes. METHOD: PON substrates from 134 references are classified and compared...
December 12, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29233102/the-gene-treatment-interaction-of-paraoxonase-1-gene-polymorphism-and-statin-therapy-on-insulin-secretion-in-japanese-patients-with-type-2-diabetes-fukuoka-diabetes-registry
#2
Akiko Sumi, Udai Nakamura, Masanori Iwase, Hiroki Fujii, Toshiaki Ohkuma, Hitoshi Ide, Tamaki Jodai-Kitamura, Yuji Komorita, Masahito Yoshinari, Yoichiro Hirakawa, Atsushi Hirano, Michiaki Kubo, Takanari Kitazono
BACKGROUND: Although statins deteriorate glucose metabolism, their glucose-lowering effects have emerged in some situations. Here, we assessed whether these effects are a consequence of statins' interaction with paraoxonase (PON)1 enzyme polymorphism. METHODS: Adult Japanese type 2 diabetes patients (n = 3798) were enrolled in a cross-sectional study. We used Q192R polymorphism of the PON1 gene as a representative single-nucleotide polymorphism and focused on the effects of the wild-type Q allele, in an additive manner...
December 12, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/29229890/q192r-polymorphism-in-the-pon1-gene-and-familial-hypercholesterolemia-in-a-saudi-population
#3
Khalid Khalaf Alharbi, May Salem Alnbaheen, Fawiziah Khalaf Alharbi, Rana M Hasanato, Imran Ali Khan
BACKGROUND: Familial hypercholesterolemia (FH) is an autosomal dominant condition characterized by abnormal levels of low-density lipoprotein (LDL) in the blood. FH is a risk factor for atherosclerosis and cardiovascular disease. The relationship between the paraoxonase 1 (PON1) gene, atherosclerosis and coronary artery disease has not been studied in Saudi patients. OBJECTIVE: To investigate the genetic associations of the Q192R polymorphism in the PON1 gene with FH in Saudi patients...
November 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/29226640/association-of-paraoxonase-1-polymorphism-and-serum-25-hydroxyvitamin-d-with-the-risk-of-cardiovascular-disease-in-patients-with-rheumatoid-arthritis
#4
Sawsan O Khoja, Yasser El Miedany, Archana P Iyer, Sami M Bahlas, Khadijah S Balamash, Mohamed F Elshal
BACKGROUND: Patients with rheumatoid arthritis (RA) have significantly increased cardiovascular (CV) morbidity and mortality that are not accounted for by traditional risk factors alone. Paraoxonase 1 (PON1) and 25-hydroxyvitamin D have been shown to be involved in the pathogenesis of CV diseases. Objective: This study aimed to investigate PON1 gene polymorphism and serum 25-hydroxyvitamin D concentrations in RA patients, and to determine their association with CV risk in RA. METHODS: Serum samples from 46 RA patients and 45 healthy controls were tested for PON1 R192Q genotypes and serum vitamin D concentrations...
November 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29226154/reduced-transferrin-levels-in-active-inflammatory-bowel-disease
#5
Malgorzata Matusiewicz, Katarzyna Neubauer, Paulina Lewandowska, Andrzej Gamian, Malgorzata Krzystek-Korpacka
Inflammatory bowel disease (IBD) is an inflammatory disease of unclear etiopathogenesis and challenging diagnosis, frequently complicated by anemia and malnutrition. C-reactive protein (CRP) remains the only biochemical marker of clinical relevance. The aim of this study was to test hypothesis that transferrin, coinfluenced by inflammation, malnutrition, anemia, and oxidative stress, may better reflect global IBD patient's condition than any other more specific index. Transferrin and other indices of inflammation, anemia, malnutrition, and oxidative stress were measured in 137 IBD patients (Crohn's disease (CD): n = 63 and ulcerative colitis (UC): n = 74) and 97 controls...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29215590/joint-effects-of-pon1-polymorphisms-and-vegetable-intake-on-ischemic-stroke-a-family-based-case-control-study
#6
Juan Juan, Xia Jiang, Xun Tang, Yiqun Wu, Kexin Sun, Xiao Xiang, Yaohua Tian, Tao Wu, Qi Sun, Peter Kraft, Yonghua Hu
Paraoxonase 1 gene (PON1) polymorphisms and dietary vegetable and fruit intake are both established determinants of ischemic stroke (IS). However, little is known about whether these factors jointly influence the risk of IS. We analyzed the main effects of PON1, as well as the interactions between PON1 and dietary vegetable or fruit intake with the risk of total IS and its subtypes in a family-based case-control study conducted among 2158 Chinese participants (1007 IS cases and 1151 IS-free controls) from 918 families...
December 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29215336/caffeine-increases-apolipoprotein-a-1-and-paraoxonase-1-but-not-paraoxonase-3-protein-levels-in-human-derived-liver-hepg2-cells
#7
Gülben Sayılan Özgün, Eray Özgün, Kıymet Tabakçıoğlu, Selma Süer Gökmen, Sevgi Eskiocak, Erol Çakır
BACKGROUND: Apolipoprotein A-1, paraoxonase-1 and paraoxonase-3 are antioxidant and anti-atherosclerotic structural high-density lipoprotein proteins that are mainly synthesized by the liver. No study has ever been performed to specifically examine the effects of caffeine on paraoxonase enzymes and on liver apolipoprotein A-1 protein levels. AIMS: To investigate the dose-dependent effects of caffeine on liver apolipoprotein A-1, paraoxonase-1 and paraoxonase-3 protein levels...
December 1, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/29204780/silver-oxide-nanoparticles-alleviate-indomethacin-induced-gastric-injury-a-novel-antiulcer-agent
#8
Neveen A Salem, Mohammed A Wahba, Wael H Eisa, Marwa El-Shamarka, Wagdy Khalil
Silver and silver oxides are gaining interest in medical applications for their prominent antibacterial and antimicrobial potentials. Recent studies suggest that nanosilver oxide has remarkable anti-inflammatory effects and enhances wound healing. Nevertheless, its effect on gastric ulcer has not yet been illustrated. Thus the current study aimed to explore the prospect protective effect of nanosilver oxide against indomethacin-induced gastric ulcer. A new approach has been followed to synthesize nanosilver oxide...
December 4, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29199478/effect-of-certain-non-steroidal-anti-inflammatory-drugs-on-the-paraoxonase-2-pon2-in-human-monocytic-cell-line-u937
#9
Ayla Solmaz Avcıkurt, Oğuzhan Korkut
The paraoxonase gene family in humans consists of three members as PON1, PON2 and PON3. PON2 can be expressed in several tissues; however, it is not released from the cells in those tissues. PON2 is also expressed in macrophages. Firstly, the commonly used NSAIDs diclofenac sodium and tenoxicam were applied on U937 cell line, the in vitro human monocyte cell line. Than PON2 specific Lactonase activity and paraoxonase family specific arylesterase were determined. Use of Diclofenac sodium in 0.845 mM dose during 6-12 h of incubation and Tenoxicam in 0...
December 3, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29189170/paraoxonase-1-characteristics-and-role-in-atherosclerosis-and-carotid-artery-disease
#10
Stella Lioudaki, Christos Verikokos, Grigorios Kouraklis, Christos Ioannou, Efi Chatziioannou, Despoina Perrea, Christos Klonaris
Paraoxonase-1 (PON-1) is a calcium-dependent enzyme that is synthesized in the liver and then secreted in blood where it is bound to high density lipoprotein(HDL). PON-1 is a hydrolase with a wide range of substrates, including lipid peroxides. It is considered responsible for many of the antiatherogenic properties of HDL. PON-1 prevents low density lipoprotein (LDL) oxidation, a process that is considered to contribute to the initiation and development of atherosclerosis. PON-1 activity and levels areinfluenced by gene polymorphisms; of the 2 common variants, one is in position 192 (Q192R) and one in position 55 (M55L)...
November 29, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/29187850/effect-of-roux-en-y-bariatric-surgery-on-lipoproteins-insulin-resistance-and-systemic-and-vascular-inflammation-in-obesity-and-diabetes
#11
Rahul Yadav, Salam Hama, Yifen Liu, Tarza Siahmansur, Jonathan Schofield, Akheel A Syed, Michael France, Philip Pemberton, Safwaan Adam, Jan Hoong Ho, Reza Aghamohammadzadeh, Shaishav Dhage, Rachelle Donn, Rayaz A Malik, John P New, Maria Jeziorska, Paul Durrington, Basil A Ammori, Handrean Soran
Purpose: Obesity is a major modifiable risk factor for cardiovascular disease. Bariatric surgery is considered to be the most effective treatment option for weight reduction in obese patients with and without type 2 diabetes (T2DM). Objective: To evaluate changes in lipoproteins, insulin resistance, mediators of systemic and vascular inflammation, and endothelial dysfunction following Roux-en-Y bariatric surgery in obese patients with and without diabetes. Materials and methods: Lipoproteins, insulin resistance, mediators of systemic and vascular inflammation, and endothelial dysfunction were measured in 37 obese patients with (n = 17) and without (n = 20) T2DM, before and 6 and 12 months after Roux-en-Y bariatric surgery...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29180002/melatonin-mitigates-thioacetamide-induced-hepatic-fibrosis-via-antioxidant-activity-and-modulation-of-proinflammatory-cytokines-and-fibrogenic-genes
#12
Mohamed A Lebda, Kadry M Sadek, Tarek K Abouzed, Hossam G Tohamy, Yasser S El-Sayed
AIMS: The potential antifibrotic effects of melatonin against induced hepatic fibrosis were explored. MAIN METHODS: Rats were allocated into four groups: placebo; thioacetamide (TAA) (200mg/kg bwt, i.p twice weekly for two months); melatonin (5mg/kgbwt, i.p daily for a week before TAA and continued for an additional two months); and melatonin plus TAA. Hepatic fibrotic changes were evaluated biochemically and histopathologically. Hepatic oxidative/antioxidative indices were assessed...
November 24, 2017: Life Sciences
https://www.readbyqxmd.com/read/29176871/effect-of-radiotherapy-on-activity-and-concentration-of-serum-paraoxonase-1-in-breast-cancer-patients
#13
Meritxell Arenas, Anabel García-Heredia, Noemí Cabré, Fedra Luciano-Mateo, Anna Hernández-Aguilera, Sebastià Sabater, Marta Bonet, Marina Gascón, Salvador Fernández-Arroyo, Isabel Fort-Gallifa, Jordi Camps, Jorge Joven
Paraoxonase-1 (PON1) is an intra-cellular antioxidant enzyme found also in the circulation associated with high-density lipoproteins. The activity of this enzyme has been shown to be decreased in breast cancer (BC) patients. The aims of our study were to investigate the changes produced by radiotherapy (RT) on activity and concentration of serum PON1 in BC patients, and to evaluate the observed variations in relation to clinical and pathological characteristics of patients and tumors, and the response to treatment...
2017: PloS One
https://www.readbyqxmd.com/read/29175178/effect-of-serum-paraoxonase-1-pon1-activity-on-follicular-development-and-pregnancy-rate-in-cattle
#14
Natália A Castro, Luiz F M Pfeifer, Jéssica S Andrade, Joao A A Rincón, Ligia M Cantarelli Pegoraro, Augusto Schneider
Paraoxonase-1 (PON1) activity has been associated with improvement in ovarian function in early postpartum dairy cows and improved in vitro embryo development. The aim of the current study was to evaluate the potential association among PON1 activity and follicular growth, diameter of the preovulatory follicle and pregnancy per artificial insemination (AI) service in cattle. In Experiment 1, cows (n=33) were subjected to an estradiol-progesterone based protocol to control time of ovulation. Starting on Day 8 of the protocol, follicular growth and serum PON1 activity were monitored...
November 22, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/29171874/serum-paraoxonase-1-activity-is-inversely-related-to-free-thyroxine-in-euthyroid-subjects-the-prevend-cohort-study
#15
Lynnda J N van Tienhoven-Wind, Eke G Gruppen, Richard W James, Stephan J L Bakker, Rijk O B Gans, Robin P F Dullaart
BACKGROUND: Low-normal thyroid function within the euthyroid range has been suggested to enhance atherosclerosis susceptibility. Paraoxonase-1 (PON-1), may protect against atherosclerotic cardiovascular disease development by attenuating oxidative stress. We evaluated relationships of PON-1 with TSH, free T4 , free T3 , lipids and apolipoprotein (apo)A-I in euthyroid subjects, and assessed whether such relationships are modified in the context of the metabolic syndrome (MetS). MATERIALS AND METHODS: Serum PON-1 activity (arylesterase activity), TSH, free T4 , free T3 , lipids and apoA-I were measured in 2206 euthyroid subjects (aged 28 to75 years; 1138 men (age 49 ± 13 years) and 1068 women (age 46 ± 12 years), recruited from the general population (PREVEND cohort)...
November 24, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29171559/prognostic-importance-of-paraoxonase-arylesterase-and-mean-platelet-volume-efficiency-in-acute-ischaemic-stroke
#16
Mehmet Tahir Gokdemir, Ali Ziya Karakilcik, Gul Sahika Gokdemir
OBJECTIVE: To study the prognostic importance activity of paraoxonase and arylesterase, and the value of mean platelet volume in patients with acute ischaemic stroke. METHODS: This case-control study was conducted at Harran University Hospital, Sanliurfa, Turkey, from January to June 2014, and comprised patients with symptoms of acute ischaemic stroke who presented to the emergency department. Paraoxonase activity, expressed in units per litre, or U/L, of serum, was evaluated in the absence of basal activity, and arylesterase activity was defined as micromoles, of phenol generated/min, and was expressed as U/L of serum...
November 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/29170064/the-role-of-paraoxonase-in-cancer
#17
REVIEW
Tiziana Bacchetti, Gianna Ferretti, Amirhossein Sahebkar
The paraoxonase (PON) gene family includes three proteins, PON1, PON2 and PON3. PON1 and PON3 are both associated with high-density lipoprotein (HDL) particles and exert anti-oxidant and anti-inflammatory properties. PON2 and PON3 are intracellular enzymes which modulate mitochondrial superoxide anion production and endoplasmic reticulum (ER) stress-induced apoptosis. The pleiotropic roles exerted by PONs have been mainly investigated in cardiovascular and neurodegenerative diseases. In recent years, overexpression of PON2 and PON3 has been observed in cancer cells and it has been proposed that both enzymes could be involved in tumor survival and stress resistance...
November 20, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/29168398/paraoxonase-arylesterase-and-lactonase-activities-of-paraoxonase-1-pon1-in-obese-and-severely-obese-women
#18
Carlo Cervellati, Gloria Bonaccorsi, Alessandro Trentini, Giuseppe Valacchi, Juana M Sanz, Monica Squerzanti, Manuela Spagnolo, Leo Massari, Ilaria Crivellari, Pantaleo Greco, Roberta Parladori, Angelina Passaro, Giorgio Ricci
Obesity is independently associated with disturbances in lipid and lipoprotein metabolism, oxidative stress, and is a well-established independent risk factor for cardiovascular diseases (CVD). Human paraoxonase 1 (PON1) is a pleotropic high-density lipoprotein (HDL)-associated enzyme with antioxidant and anti-inflammatory proprieties that have been suggested to contribute to the athero-protective function of the lipoprotein. The aim of this study was to investigate whether obesity is associated with PON1 activity and whether this association is influenced by oxidative stress, inflammation and HDL cholesterol (HDL-C) concentration...
November 23, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29156090/a-case-control-study-the-association-of-serum-paraoxonase-1-activity-and-concentration-with-the-development-of-type-2-diabetes-mellitus
#19
J Allen Crow, Edward C Meek, Robert W Wills, Janice E Chambers
BACKGROUND: A longitudinal study assessed serum paraoxonase 1 (PON1) activity and concentration as affected by age and as associated with the development of type 2 diabetes (T2D). PON1's recently established physiological function is the hydrolysis of lipolactones in oxidized LDL particles. METHODS: Serum samples and clinical data collected and stored at different time points over a 20 year interval in the Air Force Health Study were analyzed. PON1 activity and concentration and C-reactive protein (CRP) concentration in samples from the same individuals 20 years apart were compared using a paired t test (n=159)...
November 20, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29151419/-preparation-of-paraoxonase-liposomes-and-their-pharmacokinetics-in-rats
#20
Zhenkun Han, Suwen Jiang, Baoqin Fu, Min Zhao
OBJECTIVE: To prepare paraoxonase 1 (PON1) liposomes, and investigate pharmacokinetics of common PON1 liposomes (L-PON1) and polyethylene glycol-modified PON1 long circulating liposomes (PEG-PON1-LCL) in rats after intravenous administration. METHODS: L-PON1 and PEG-PON1-LCL were prepared by film dispersion method. The entrapment efficiency, mean diameter and Zeta potential of the liposomes were measured, and the stability was evaluated. Thirty-six Wistar rats were divided into three groups according to random number table, with 12 rats in each group...
November 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
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