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High Density Lipoprotein

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https://www.readbyqxmd.com/read/29045950/leonurine-prevents-atherosclerosis-via-promoting-the-expression-of-abca1-and-abcg1-in-a-ppar%C3%AE-lxr%C3%AE-signaling-pathway-dependent-manner
#1
Ting Jiang, Kun Ren, Qian Chen, Heng Li, Rong Yao, Hu Hu, Yun-Cheng Lv, Guo-Jun Zhao
BACKGROUND/AIMS: Previous studies have demonstrated that leonurine, a unique alkaloid compound of Herba leonuri, can exert anti-oxidative and anti-inflammatory effects on the development of atherosclerosis (AS). This study was designed to investigate the effects of leonurine on cholesterol efflux from THP-1 macrophage-derived foam cells and development of atherosclerotic lesions in apoE-/- mice, and further determine the potential mechanisms. METHODS: Human THP-1 cells were fully differentiated into foam cells by the pre-treatment with phorbol-12-myristate-13-acetate (PMA) and oxidized density lipoproteins (ox-LDL)...
October 18, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29044720/observational-comparative-effectiveness-of-pharmaceutical-treatments-for-obesity-within-the-veterans-health-administration
#2
Ted R Grabarczyk
STUDY OBJECTIVE: To compare the effectiveness of weight-management medications used to assist with weight loss in real-world clinical practice in the Veterans Health Administration (VHA). DESIGN: Retrospective, multicenter, observational cohort study. DATA SOURCE: National VA Corporate Data Warehouse. PATIENTS: A total of 66,035 VA patients aged 18 years or older with a body mass index of 25 kg/m(2) or greater who had an initial fill for a study medication (orlistat [6153 patients], phentermine [304 patients], lorcaserin [298 patients], or phentermine-topiramate extended release [233 patients]) or participation in the VA's MOVE! weight management program with at least three total visits in a clinic coded as a MOVE clinic in the subsequent 24 weeks (59,047 patients) between January 1, 2012 and July 1, 2016...
October 17, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/29044294/serum-levels-of-anti-pon1-and-anti-hdl-antibodies-as-potential-biomarkers-of-premature-atherosclerosis-in-systemic-lupus-erythematosus
#3
Patricia López, Javier Rodríguez-Carrio, Aleida Martínez-Zapico, Ángel I Pérez-Álvarez, Raquel López-Mejías, Lorena Benavente, Lourdes Mozo Mozo, Luis Caminal-Montero, Miguel A González-Gay, Ana Suárez
The present study aimed to evaluate the possible role of immunoglobulin G (IgG) antibodies against high-density lipoproteins (HDL) and paraoxonase 1 (PON1) as possible biomarkers of cardiovascular disease (CVD) in systemic lupus erythematosus (SLE). To this end, levels of these autoantibodies, PON1 activity and total antioxidant capacity were quantified in serum samples from 198 SLE patients, 100 healthy controls (HC) and 42 non-autoimmune individuals with traditional cardiovascular risk factors. PON1 rs662 polymorphism was analysed in a subgroup of patients and controls...
October 10, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29044032/-the-relationship-between-serum-vitamin-d-levels-and-cardiovascular-risk-factors-among-icelandic-children
#4
Thorunn Hannesdottir, Hannes Hrafnkelsson, Erlingur Johannsson, Emil L Sigurdsson
OBJECTIVE: To determine the relationship between serum vitamin D levels and known cardiometabolic risk factors among healthy Icelandic children as well as study these connections independent of body mass index (BMI). METHODS: We assessed the relationship between serum 25-hydroxyvitamin D, adiposity measured as BMI and 7 cardiometabolic risk factors (high blood pressure, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, blood glucose and serum insulin)...
September 2017: Læknablađiđ
https://www.readbyqxmd.com/read/29042429/both-light-intensity-and-moderate-to-vigorous-physical-activity-measured-by-accelerometry-are-favorably-associated-with-cardiometabolic-risk-factors-in-older-women-the-objective-physical-activity-and-cardiovascular-health-opach-study
#5
Michael J LaMonte, Cora E Lewis, David M Buchner, Kelly R Evenson, Eileen Rillamas-Sun, Chongzhi Di, I-Min Lee, John Bellettiere, Marcia L Stefanick, Charles B Eaton, Barbara V Howard, Chloe Bird, Andrea Z LaCroix
BACKGROUND: The relationship between light intensity physical activity (PA), which is common in older adults, and cardiovascular disease (CVD) risk factors is unclear. This study examined associations of accelerometer-measured PA intensity with CVD risk factors in older women of different race-ethnicities. METHODS AND RESULTS: Cross-sectional analyses were conducted in 4832 women (mean age 78.9 years; 52.5% white, 30.5% black, 17.1% Hispanic) who were without known CVD and wore triaxial accelerometers a minimum of 4 of 7 days with ≥10 hours/d awake wear-time...
October 17, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29042249/prevalence-and-biochemical-risk-factors-of-diabetic-peripheral-neuropathy-with-or-without-neuropathic-pain-in-taiwanese-adults-with-type-2-diabetes-mellitus
#6
Yen-Wei Pai, Ching-Heng Lin, I-Te Lee, Ming-Hong Chang
AIMS: To investigate the prevalence and risk factors for diabetic peripheral neuropathy with or without neuropathic pain in Taiwanese. METHODS: A cross-sectional, hospital-based observational study was conducted. We enrolled 2837 adults with type 2 diabetes mellitus. Diabetic peripheral neuropathy with or without pain were diagnosed using 2 validated screening tools, namely the Michigan Neuropathy Screening Instrument and Douleur Neuropathique 4 questionnaire. RESULTS: In our sample, 2233 participants had no neuropathy, 476 had diabetic peripheral neuropathy without pain, and 128 had diabetic peripheral neuropathy with neuropathic pain, representing an overall diabetic peripheral neuropathy prevalence of 21...
September 28, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29042132/low-very-low-density-lipoprotein-cholesterol-but-high-very-low-density-lipoprotein-receptor-mrna-expression-in-peripheral-white-blood-cells-an-atherogenic-phenotype-for-atherosclerosis-in-a-community-based-population
#7
Fan Zhao, Yue Qi, Jing Liu, Wei Wang, Wuxiang Xie, Jiayi Sun, Jun Liu, Yongchen Hao, Miao Wang, Yan Li, Dong Zhao
Very low-density lipoprotein cholesterol (VLDL-C), via binding very low-density lipoprotein receptor (VLDLR), can induce the development of atherosclerosis. Besides monocytes, VLDLR expression is detected in various peripheral white blood cells (WBCs), yet its underlying role remains unclear. We thereby aimed to test the hypothesis that VLDLR in all types of peripheral WBCs may be involved in the association between VLDL-C and atherosclerosis. VLDLR mRNA expression in peripheral WBC and plasma VLDL-C levels were measured in 747 participants from a community-based study...
August 31, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29041886/-polymorphisms-in-genes-of-cytokines-and-matrix-metalloproteinases-associated-with-ischemic-heart-disease-in-patients-with-type-2-diabetes
#8
V V Klimontov, V A Shevchenko, M D Bulumbaeva, F V Prokof 'ev, I V Konenkov
OBJECTIVE: To examine associations between ischemic heart disease (IHD) and polymorphisms in cytokine genes (IL-1B, IL-4, IL-6, IL-10, TNFA, VEGF) and matrix metalloproteinase genes (MMP2, MMP3, MMP9) in patients with type 2 diabetes. MATERIAL AND METHODS: We studied 232 Caucasian diabetic subjects (33 men and 199 women aged 50-70 years). In 93 patients IHD was verified by treadmill test and/or coronary angiography (86 subjects with stable angina, 19 with previous myocardial infarction)...
August 2017: Kardiologiia
https://www.readbyqxmd.com/read/29041003/depression-in-the-context-of-medical-disorders-new-pharmacological-pathways-revisited
#9
Undine E Lang, Marc Walter
The depressive state has been characterised as one of elevated inflammation, changed cardiovascular parameters and a deranged metabolic situation all of which holds promise for a better understanding and handling of treatment-resistance in affective disorders as well as for future developments in treatment algorithms. In this context several biomarkers are differentially regulated by antidepressant treatment and connected to metabolic, inflammatory, cardiovascular and apoptotic components of the pathophysiology, i...
October 17, 2017: Neuro-Signals
https://www.readbyqxmd.com/read/29040959/marantodes-pumilum-kacip-fatimah-enhances-in-vitro-glucose-uptake-in-3t3-l1-adipocyte-cells-and-reduces-pancreatic-complications-in-streptozotocin-nicotinamide-induced-male-diabetic-rats
#10
Siti Hajar Adam, Nelli Giribabu, Noor Mazuin Abu Bakar, Naguib Salleh
Marontades pumilum is claimed to have beneficial effects in the treatment of diabetes mellitus (DM), however the underlying mechanisms were not fully identified. In this study, we hypothesized that M. pumilum could help to enhance cellular glucose uptake and reduces pancreatic complications, which contributed towards its beneficial effects in DM. METHODS: Two parameters were measured (i) rate of glucose uptake by 3T3-L1 adipocyte cells in-vitro (ii) degree of pancreatic destruction in streptozotocin-nicotinamide induced male diabetic rats receiving M...
October 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29040956/antihyperlipidemic-effect-of-pistacia-khinjuk
#11
Faiza Kamal, Muhammad Shahzad, Tanveer Ahmad, Zaheer Ahmed, Rasool Bakhash Tareen, Rabiya Naz, Ali Ahmad
BACKGROUND: Hyperlipidemia is a metabolic disorder that is caused by high levels of triglycerides and cholesterol in blood. Using of plants for the treatment of various ailments is a traditional practice in developing countries. The main objective of the study is to analyse the nutritional composition of Pistacia khinjuk and to assess its anti-hyperlipidemic activity. MATERIALS AND METHODS: In the present study, the ethanolic extract of Pistacia khinjuk leaves was evaluated for antihyperlipidemic activity...
October 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29040716/dietary-carbohydrates-components-of-energy-balance-and-associated-health-outcomes
#12
Harry A Smith, Javier T Gonzalez, Dylan Thompson, James A Betts
The role of dietary carbohydrates in the development of obesity and associated metabolic dysfunction has recently been questioned. Within the last decade, the Scientific Advisory Committee on Nutrition carried out a comprehensive evaluation of the role of dietary carbohydrates in human health. The current review aims to complement and extend this report by providing specific consideration of the effects of the component parts of energy balance, their interactions, and their culmination on energy storage and health...
October 5, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/29038593/gender-and-lesion-number-dependent-difference-in-atherogenic-index-of-plasma-in-chinese-people-with-coronary-heart-disease
#13
Wei Ni, Zhenyu Zhou, Tao Liu, Haoyu Wang, Jianping Deng, Xiaoyan Liu, Guoqiang Xing
Few studies has investigated the interrelationship between Atherogenic index of plasma (AIP) and coronary heart disease (CHD) especially in Asians. AIP is the logarithmically transformed ratio of triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C), and is thought to be associated with arteriosclerosis, hypertension, diabetes and cardiovascular diseases. Of the 463 patients from Central Hospital of Nanchong in 2011-2014 diagnosed with angiograms, 229 CHD (>50% stenosis in one or more arteries) and the rest 234 were the controls (maximum stenosis < 10% in any artery) according to the world health organization (who) diagnostic criteria...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29038389/association-of-glomerular-filtration-rate-with-cardiometabolic-risk-factors-in-iranian-adolescents-caspian-iii-study
#14
Ramin Tajbakhsh, Ramin Heshmat, Saeid Safiri, Mahya Vafaeenia, Mohammad Esmaeil Motlagh, Morteza Mansourian, Shaghayegh Beshtar, Omid Safari, Hamid Asayesh, Hossein Ansari, Mostafa Qorbani, Roya Kelishadi
INTRODUCTION: This study aimed to assess the association of glomerular filtration rate (GFR) with cardiometabolic risk factors in Iranian adolescents. MATERIALS AND METHODS: Data of the 3rd round of a school-based surveillance system entitled "Childhood and Adolescence Surveillance and PreventIon of Adult Non-communicable Disease (CASPIAN III)" study was used for this study. A sample of 367 adolescents aged between 10 and 18 years was randomly selected. Glomerular filtration rate was estimated using the original and the updated Schwartz equations...
October 2017: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29038168/fasting-vs-non-fasting-and-low-density-lipoprotein-cholesterol-accuracy
#15
Vasanth Sathiyakumar, Jihwan Park, Asieh Golozar, Mariana Lazo, Renato Quispe, Eliseo Guallar, Roger S Blumenthal, Steven R Jones, Seth S Martin
Background -Recent recommendations favoring non-fasting lipid assessment may impact low-density lipoprotein-cholesterol (LDL-C) estimation. The novel method of LDL-C estimation (LDL-CN) uses a flexible approach to derive patient-specific triglyceride (TG) to very low-density lipoprotein-cholesterol ratios. This adaptability may confer an accuracy advantage in non-fasting patients over the fixed approach of the classical Friedewald method (LDL-CF). Methods -We used a US cross-sectional sample of 1,545,634 patients (959,153 fasting ≥10-12 hours; 586,481 non-fasting) from the second harvest of the Very Large Database of Lipids study to assess for the first time the impact of fasting status on novel LDL-C accuracy...
October 16, 2017: Circulation
https://www.readbyqxmd.com/read/29038049/inhibition-of-egfr-attenuates-fibrosis-and-stellate-cell-activation-in-diet-induced-model-of-nonalcoholic-fatty-liver-disease
#16
Dandan Liang, Hongjin Chen, Leping Zhao, Wenxin Zhang, Jie Hu, Zhiguo Liu, Peng Zhong, Wei Wang, Jingying Wang, Guang Liang
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease. NAFLD begins with steatosis and advances to nonalcoholic steatohepatitis (NASH) and cirrhosis. The molecular mechanisms involved in NAFLD progression are not understood. Based on recent studies showing dysregulation of epidermal growth factor receptor (EGFR) in animal models of liver injury, we sought to determine if inhibition of EGFR mitigates liver fibrosis and HSC activation in NAFLD. We utilized the high fat diet (HFD)-induced murine model of liver injury to study the role of EGFR in NAFLD...
October 13, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29037827/improvement-of-serum-lipids-concentration-in-a-general-population-historical-cohort-why
#17
Juan Antonio Gómez Gerique, Ignacio Ferreira Gonzalez, Miguel Angel Rubio Herrera, David Lora Pablos, Beatriz Martín Ballesteros, Romina García Sardina, Agustín Gómez de la Cámara
BACKGROUND: Knowledge about the harmful effects of high levels of low-density lipoprotein cholesterol (cLDL) in adults increased after the publication of various guidelines, leading to closer control and more treatment. We hypothesized that these health care changes would result in an overall improvement in the lipid profile of the population. OBJECTIVE: To determine the evolution of the lipid profile in the population of Spain from the Diet and Risk of Cardiovascular Disease in Spain cohort...
October 13, 2017: Clínica e Investigación en Arteriosclerosis
https://www.readbyqxmd.com/read/29037431/effect-of-chlorella-supplementation-on-cardiovascular-risk-factors-a%C3%A2-meta-analysis-of-randomized-controlled-trials
#18
Aziz A Fallah, Elham Sarmast, Saied Habibian Dehkordi, Javad Engardeh, Leila Mahmoodnia, Arsalan Khaledifar, Tina Jafari
BACKGROUND & AIMS: The effect of Chlorella supplementation on cardiovascular risk factors of subjects with different health status has not been conclusively studied. Therefore, the efficacy of Chlorella supplementation on cardiovascular risk factors was assessed through a meta-analysis. METHODS: A literature search on five electronic databases was performed and related randomized controlled trials (RCTs) published until 15 January 2017 were identified. For each study, the effect size of each outcome was presented as Un-standardized mean difference and 95% confidence interval (CI)...
October 3, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29037330/waist-circumference-shows-the-highest-predictive-value-for-metabolic-syndrome-and-waist-to-hip-ratio-for-its-components-in-spanish-adolescents
#19
Javier S Perona, Jacqueline Schmidt-RioValle, Blanca Rueda-Medina, María Correa-Rodríguez, Emilio González-Jiménez
Both waist circumference (WC) and waist-to-hip ratio (WHR) have been proposed as predictors of metabolic syndrome (MetS) in adolescents, but no consensus has been reached to date. This study hypothesizes that WC provides a greater predictive value for MetS in Spanish adolescents than WHR. A cross-sectional study was performed on 1001 adolescents (13.2 ± 1.2 years) randomly recruited from schools in southeast Spain. Anthropometric measures were correlated with the components of MetS (triglycerides, glucose, blood pressure, and high-density lipoprotein cholesterol) as well as inflammation markers (interleukin-6 and tumor necrosis factor-alpha , C-reactive protein, and ceruloplasmin)...
September 2017: Nutrition Research
https://www.readbyqxmd.com/read/29036913/alpha-galacto-oligosaccharides-at-low-dose-improve-liver-steatosis-in-a-high-fat-diet-mouse-model
#20
Eric Chappuis, Fanny Morel-Depeisse, Bruno Bariohay, Julien Roux
Non-Alcoholic Fatty Liver Disease (NAFLD) is the major liver disease worldwide and is linked to the development of metabolic syndrome and obesity. As alpha-galacto-oligosaccharides (α-GOS) from legumes have been shown to reduce body weight and hyperphagia in overweight adults, it was hypothesized that they would exert benefits on the development of metabolic syndrome and associated NAFLD in a rodent model. C57Bl/6J mice were fed a high-fat diet until they developed metabolic syndrome and were then orally treated either with α-GOS at a physiological dose (2...
October 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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