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High Density Lipoprotein

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https://www.readbyqxmd.com/read/29240892/high-density-lipoprotein-hdl-and-infections-a-versatile-culprit
#1
Thimoteus Speer, Stephen Zewinger
No abstract text is available yet for this article.
December 11, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29239221/high-density-lipoprotein-and-cardiac-glucose-metabolism-implications-for-management-of-acute-coronary-syndromes
#2
Adele L Richart, Sarah E Heywood, Andrew L Siebel, Bronwyn A Kingwell
No abstract text is available yet for this article.
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29238464/curcumin-enhances-liver-sirt3-expression-in-the-rat-model-of-cirrhosis
#3
Sara Chenari, Fatemeh Safari, Ali Moradi
Objectives: Bill duct ligation (BDL) is a representative model of biliary cholestasis in animals. Curcumin has a protective effect on the liver; however, its underlying mechanisms are not completely known. This study explored the hepatoprotective activity of curcumin on hepatic damage via measuring the expression of sirtuin3 (SIRT3), AMP-activated protein kinase (AMPK), carnitine palmitoyltransferase 1A (CPT-1A), isocitrate dehydrogenase2 (IDH2) and manganese superoxide dismutase (MnSOD) as well as the level of serum lipid profile in the BDL fibrotic rat model...
December 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29237687/metabolic-profiling-of-adiponectin-levels-in-adults-mendelian-randomization-analysis
#4
Maria Carolina Borges, Aluísio J D Barros, Diana L Santos Ferreira, Juan Pablo Casas, Bernardo Lessa Horta, Mika Kivimaki, Meena Kumari, Usha Menon, Tom R Gaunt, Yoav Ben-Shlomo, Deise F Freitas, Isabel O Oliveira, Aleksandra Gentry-Maharaj, Evangelia Fourkala, Debbie A Lawlor, Aroon D Hingorani
BACKGROUND: Adiponectin, a circulating adipocyte-derived protein, has insulin-sensitizing, anti-inflammatory, antiatherogenic, and cardiomyocyte-protective properties in animal models. However, the systemic effects of adiponectin in humans are unknown. Our aims were to define the metabolic profile associated with higher blood adiponectin concentration and investigate whether variation in adiponectin concentration affects the systemic metabolic profile. METHODS AND RESULTS: We applied multivariable regression in ≤5909 adults and Mendelian randomization (using cis-acting genetic variants in the vicinity of the adiponectin gene as instrumental variables) for analyzing the causal effect of adiponectin in the metabolic profile of ≤37 545 adults...
December 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/29237679/statin-effects-on-metabolic-profiles-data-from-the-prevend-it-prevention-of-renal-and-vascular-end-stage-disease-intervention-trial
#5
Daniel Kofink, Ruben N Eppinga, Wiek H van Gilst, Stephan J L Bakker, Robin P F Dullaart, Pim van der Harst, Folkert W Asselbergs
BACKGROUND: Statins lower cholesterol by inhibiting HMG-CoA reductase, the rate-limiting enzyme of the metabolic pathway that produces cholesterol and other isoprenoids. Little is known about their effects on metabolite and lipoprotein subclass profiles. We, therefore, investigated the molecular changes associated with pravastatin treatment compared with placebo administration using a nuclear magnetic resonance-based metabolomics platform. METHODS AND RESULTS: We performed metabolic profiling of 231 lipoprotein and metabolite measures in the PREVEND IT (Prevention of Renal and Vascular End-stage Disease Intervention Trial) study, a placebo-controlled randomized clinical trial designed to test the effects of pravastatin (40 mg once daily) on cardiovascular risk...
December 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/29237302/the-hypoglycemic-and-antioxidant-activities-of-garden-cress-lepidium-sativum-l-seed-on-alloxan-induced-diabetic-male-rats
#6
Eman S Attia, Afaf H Amer, Manal A Hasanein
The hypoglycemic and antioxidants activities of the methanol extract of Lepidium sativum seeds was tested in alloxan-induced diabetic male rats. Thirty male albino rats weighing 190-200 g were divided into five groups as follows: negative control, positive control and three diabetic groups treated with three concentrations of L. sativum methanol extract for four weeks. Induction of hyperglycemia in the positive control group increased blood glucose, glycated hemoglobin A1c, immunoglobulins, liver enzyme, lipid peroxide and kidney function, total cholesterol, low-density lipoproteins, very low-density lipoproteins and decreased antioxidants and high-density lipoproteins compared with the negative control...
December 13, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29235659/effect-of-metabolic-syndrome-on-late-life-depression-associations-with-disease-severity-and-treatment-resistance
#7
John S Mulvahill, Ginger E Nicol, David Dixon, Eric J Lenze, Jordan F Karp, Charles F Reynolds, Daniel M Blumberger, Benoit H Mulsant
BACKGROUND/OBJECTIVES: Metabolic syndrome (MetS) is the co-occurrence of obesity and metabolic derangements. Prior research implicates MetS in prolongation of the course of depression in older adults, but its effect on antidepressant response is unknown in this population. The objective was to determine whether MetS and related metabolic dyscrasias are associated with decreased rate of remission from depression in older adults treated pharmacologically for depression. DESIGN: Secondary analysis of a randomized controlled trial...
December 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29235396/brain-derived-neurotrophic-factor-bdnf-serum-level-in-women-with-first-episode-depression-correlation-with-clinical-and-metabolic-parameters
#8
Maria Skibinska, Pawel Kapelski, Aleksandra Rajewska-Rager, Joanna Pawlak, Aleksandra Szczepankiewicz, Beata Narozna, Joanna Twarowska-Hauser, Monika Dmitrzak-Weglarz
BACKGROUND: Brain-derived neurotrophic factor (BDNF) influences neuron differentiation during development, as well as the synaptic plasticity and neuron survival in adulthood. BDNF has been implicated in the pathogenesis of psychiatric disorders and its serum level is a potential biomarker for depression. The aim of this study was to examine serum levels of BDNF in first-episode depression and its correlation with clinical and metabolic parameters. MATERIALS AND METHODS: The study was performed on a group of 60 women: 30 diagnosed with a first-episode of depression and 30 healthy controls...
December 13, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/29235373/pro-inflammatory-cytokine-induced-lipolysis-after-an-episode-of-acute-pancreatitis
#9
Sayali A Pendharkar, Ruma G Singh, Maxim S Petrov
CONTEXT: Pro-inflammatory cytokine-stimulated lipolysis is one of the mechanisms underlying the pathogenesis of type 2 diabetes. However, whether it plays a role in the pathogenesis of post-pancreatitis diabetes mellitus (PPDM) remains unknown. OBJECTIVE: To investigate the associations between markers of lipid metabolism and pro-inflammatory cytokines in individuals after acute pancreatitis (AP) in general, and in individuals with abnormal glucose metabolism (AGM) following AP in particular...
December 13, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29235180/the-effects-of-hypoglycemia-and-weight-loss-of-total-lignans-from-fructus-arctii-in-kkay-mice-and-its-mechanisms-of-the-activity
#10
Yingying Gao, Chenchen Gu, Kai Wang, Haiying Wang, Kefeng Ruan, Zhaohui Xu, Yi Feng
Fructus Arctii (great burdock achene) is the dried ripe fruit of Arctium lappa L. (family Asteraceae) and is included in the Chinese pharmacopoeia. It has been reported that the clinical use of Fructus Arctii resulted in a satisfactory hypoglycemic effect in diabetic patients. This study aimed to investigate antidiabetic activity and mechanism of total lignans from Fructus Arctii (TLFA) in KKAy mice, a spontaneous Type 2 diabetic rodent model that exhibits marked obesity. In this study, KKAy mice were gavaged once daily with solvents (0...
December 13, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29235048/serum-lipid-enzyme-and-hematological-responses-of-broilers-fed-acacia-angustissima-leaf-meal-based-diets
#11
Sharai Ncube, Petronella Tapiwa Saidi, Musavengana Tapera Tivapasi, Venancio Edward Imbayarwo-Chikosi, Tinyiko Edward Halimani
The objective of the study was to determine serum lipid, enzyme, and hematological responses of broilers to Acacia angustissima leaf meal. Acacia angustissima leaves were harvested at mid maturity, ground into a leaf meal, and included in broiler diets at 0, 5, and 10%. One hundred and fifty-day-old chicks of 41.7 ± 1.560 g were randomly allocated to 15 groups of the three diets. Feed and water were provided ad libitum throughout the trial. At days 14, 28, and 42, 4 ml of blood were collected from the jugular vein in plain vacutainer tubes for alanine aminotransferase (ALT), alkaline phosphatase (ALP), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and total cholesterol (TC) analyses...
December 12, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29235017/oral-treatment-with-a-rattlesnake-native-polypeptide-crotamine-efficiently-inhibits-the-tumor-growth-with-no-potential-toxicity-for-the-host-animal-and-with-suggestive-positive-effects-on-animal-metabolic-profile
#12
Joana D Campeiro, Marcelo P Marinovic, Fernando Cintra Carapeto, Caroline Dal Mas, Gabriela Guilherme Monte, Lucas Carvalho Porta, Marcela B Nering, Eduardo B Oliveira, Mirian A F Hayashi
The efficacy of crotamine as antitumoral was first demonstrated by daily intraperitoneal (IP) injections of low doses of this toxin in an animal model bearing melanoma tumors. Significant inhibition of tumor growth and increased lifespan of mice bearing tumor was also noticed after 21 consecutive days of this daily IP administration of crotamine. However, due to the limited acceptance of treatments by IP route in clinical conditions, herein, we evaluated the antitumor effect of this native polypeptide employing the oral route...
December 12, 2017: Amino Acids
https://www.readbyqxmd.com/read/29235010/metabolic-changes-up-to-10%C3%A2-years-after-gastric-bypass
#13
Daniela Vicinansa Mônaco-Ferreira, Vânia Aparecida Leandro-Merhi, Nilton César Aranha, Andre Brandalise, Nelson Ary Brandalise
OBJECTIVE: The aim of this study was to investigate the lipid and glycemic profiles of patients up to 10 years after Roux-en-Y gastric bypass. METHOD: A retrospective, longitudinal study was conducted at a multidisciplinary center for the treatment of obesity in the state of São Paulo, Brazil. The study included 150 patients submitted to unbanded laparoscopic Roux-en-Y gastric bypass. The metabolic profile included total cholesterol and fractions, triglycerides, and fasting glucose...
December 12, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29234908/characterization-of-type-iv-antifreeze-gene-in-nile-tilapia-oreochromis-niloticus-and-influence-of-cold-and-hot-weather-on-its-expression-and-some-immune-related-genes
#14
Asmma Y Ammar, Abeer F El Nahas, Shawky Mahmoud, Mohamed E Barakat, Asmaa M Hassan
The aim of this work is to study the effect of the thermal stress of ambient temperature during winter and summer on the expression of type IV antifreeze gene (ANF IV) in different tissues of Nile tilapia (Oreochromis niloticus) as well as some immune-related genes. At first, genomic ANF IV gene was characterized from one fish; 124 amino acids were identified with 92.7% similarity with that on the gene bank. Expression of ANF IV and immune-related genes were done twice, once at the end of December (winter sample, temperature 14 °C) and the other at August (summer sample, temperature 36 °C)...
December 12, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/29234897/potential-influence-of-the-phthalates-on-normal-liver-function-and-cardiometabolic-risk-in-males
#15
Nataša Milošević, Nataša Milić, Dragana Živanović Bosić, Ivana Bajkin, Ivanka Perčić, Ludovico Abenavoli, Milica Medić Stojanoska
Phthalates are ubiquitous environmental contaminants, massively used in industry as plasticizers and additives in cosmetics, which may impair the human endocrine system inducing fertility problems, respiratory diseases, obesity, and neuropsychological disorders. The aim of this study was to examine the influence of the monoethyl phthalate (MEP) and mono-(2-ethylhexyl) phthalate (MEHP) on the liver function and cardiometabolic risk factors in males. In this research, 102 male participants (51 normal weight and 51 overweight/obese) were enrolled and examined for phthalate metabolites exposure in urine samples after 12 h of fasting...
December 13, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29234430/antidyslipidemic-anti-inflammatory-and-antioxidant-activities-of-aqueous-leaf-extract-of-dioscoreophyllum-cumminsii-stapf-diels-in-high-fat-diet-fed-rats
#16
O B Ibitoye, U M Ghali, J B Adekunle, J N Uwazie, T O Ajiboye
Dioscoreophyllum cumminsii (Stapf) Diels leaves are widely used in the treatment of diabetes, obesity, and cardiovascular related complications in Nigeria. This study investigates the anti-inflammatory and antiobesity effect of aqueous extract of Dioscoreophyllum cumminsii leaves in high-fat diet- (HFD-) induced obese rats. HFD-fed rats were given 100, 200, and 400 mgkg-1 body weight of aqueous extract of Dioscoreophyllum cumminsii leaves for 4 weeks starting from 9th week of HFD treatment. D. cumminsii leaves aqueous extract reversed HFD-mediated decrease in the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glucose 6-phosphate dehydrogenase...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29232321/elevated-interleukin-1%C3%AE-and-interleukin-6-levels-in-the-serum-of-children-with-hyperuricemia
#17
Yazhen Di, Jiapei Wang, Yuanling Chen, Nan Sun, Ling Wu, Xiahua Dai, Mengjiao Shen, Qianqian Ying, Shiwei Fu
PURPOSES: The aim of this study was to investigate the serum levels and clinical significance of interleukin 1β (IL-1β) and IL-6 in children with hyperuricemia (HUA). METHODS: We included 71 children with HUA and 71 children with no HUA as control subjects. Children with HUA were divided into groups I and II according to whether they had a history of acute gout-like attacks (including sudden monoarthritis of rapid onset with intense pain and swelling). Group I was examined twice (A, in the acute phase; B, in the remission phase)...
December 12, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29231843/the-lipid-lowering-and-cardioprotective-effects-of-vernonia-calvoana-ethanol-extract-in-acetaminophen-treated-rats
#18
Godwin Eneji Egbung, Item Justin Atangwho, Ochuole Diana Odey, Victor Ndubuisi Ndiodimma
Background: Paracetamol overdose/abuse as a result of self-medication is a common occurrence amongst people living in low/middle income countries. The present study was designed to investigate the hypolipidemic and cardioprotective potentials of Vernonia calvoana (VC) ethanol extract in acetaminophen (paracetamol)-treated rats. Methods: Thirty-five Wistar rats weighing 100-150 g were randomly assigned into five groups of seven rats each. Groups 2-5 received high doses of paracetamol to induce liver damage, while group 1 was used as normal control...
December 12, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/29231585/-regulative-effects-of-the-acupuncture-on-glucose-and-lipid-metabolism-disorder-in-the-patients-of-metabolic-syndrome
#19
Jie Chen, Haijiao Xing, Qing Li, Mei Li, Shaojin Wang
OBJECTIVE: To observe the regulative effects of the acupuncture on glucose and lipid metabolism disorder in the patients of metabolic syndrome. METHODS: Seventy-six patients of metabolic syndrome were rando-mized into an acupuncture plus western medicine group (37 cases) and a western medicine group (39 cases). In the western medicine group, the conventional western medication was used for 40 days. In the acupuncture plus western medicine group, the acupuncture was combined on the basis of the treatment as the western medicine group, the acupoints were Danzhong (CV 17), Zhongwan (CV 12), Tianshu (ST 25), etc...
April 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231064/pharmacokinetics-pharmacodynamics-and-clinical-efficacy-of-non-statin-treatments-for-hypercholesterolemia
#20
Arrigo F G Cicero, Marilisa Bove, Claudio Borghi
Hypercholesterolemia is the main modifiable risk factor for atherosclerosis progression and cardiovascular disease (CVD) development. Its pharmacological management is usually based on the prescription of statins, that in some cases are not however fully effective to reach the desired Low-Density-Lipoproteins cholesterol (LDL-C) target, or are not tolerated by patients due to side effects. Areas covered: This manuscript summarizes the basic properties of the emerging new classes of lipid-lowering drugs such as ezetimibe, Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) inhibitors, and Microsomal Triglyceride Transfer Protein (MTP) inhibitors, also citing new drugs in development...
December 13, 2017: Expert Opinion on Drug Metabolism & Toxicology
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