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https://www.readbyqxmd.com/read/28681330/antiproliferative-activity-and-vegf-expression-reduction-in-mcf7-and-pc-3-cancer-cells-by-paclitaxel-and-imatinib-co-encapsulation-in-folate-targeted-liposomes
#1
Marco Júnio Peres-Filho, Alexandre Pereira Dos Santos, Thais Leite Nascimento, Renato Ivan de Ávila, Fabrícia Saba Ferreira, Marize Campos Valadares, Eliana Martins Lima
Co-encapsulation of anticancer drugs paclitaxel and imatinib in nanocarriers is a promising strategy to optimize cancer treatment. Aiming to combine the cytotoxic and antiangiogenic properties of the drugs, a liposome formulation targeted to folate receptor co-encapsulating paclitaxel and imatinib was designed in this work. An efficient method was optimized for the synthesis of the lipid anchor DSPE-PEG(2000)-folic acid (FA). The structure of the obtained product was confirmed by RMN, FT-IR, and ESI-MS techniques...
July 5, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28624892/a-meta-analysis-of-manual-versus-remote-magnetic-navigation-for-ventricular-tachycardia-ablation
#2
Mohit K Turagam, Donita Atkins, Roderick Tung, Moussa Mansour, Jeremy Ruskin, Jie Cheng, Luigi Di Biase, Andrea Natale, Dhanunjaya Lakkireddy
BACKGROUND: There are limited studies on the safety and efficacy of remote magnetic navigation (RMN) versus manual navigation (MAN) in ventricular tachycardia (VT) ablation. METHODS: A comprehensive literature search was performed using the keywords VT ablation, stereotaxis, RMN and MAN in Pubmed, Ebsco, Web of Science, Cochrane, and Google scholar databases. RESULTS: The analysis included seven studies (one randomized, three prospective observational, and three retrospective) including 779 patients [both structural heart disease (SHD) and idiopathic VT] comparing RMN (N = 433) and MAN (N = 339) in VT ablation...
June 17, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/28609495/pink-and-white-esthetics-of-a-new-zirconia-implant-a-6-month-to-8-year-follow-up
#3
Deirdre G Beekmans, Bart Rmn Beekmans, Marco S Cune
The aim of this study was to analyze changes in pink and white esthetics in the anterior zone through evaluation of an immediately placed zirconia implant using the Pink and White Esthetic Scores (PES and WES) in 20 patients. Two clinical photographs were compared: one taken directly after placement of the permanent crown (mean PES = 12.8; mean WES = 8.5) and the other taken at a later time (mean PES = 12.8; mean WES = 8.6; not significant). Volunteers found it difficult to correctly identify the implant. Patients completed a questionnaire regarding the pink and white implant esthetics...
July 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/28607610/remote-magnetic-catheter-navigation-versus-conventional-ablation-in-atrial-fibrillation-ablation-fluoroscopy-reduction
#4
Paul Chun Yih Lim, Joseph Jia Hong Toh, Julian Kenrick Xing Yuan Loh, Edward Chun Yi Lee, Daniel Thuan Tee Chong, Boon Yew Tan, Kah Leng Ho, Chi Keong Ching, Wee Siong Teo
BACKGROUND: Percutaneous transcatheter radiofrequency ablation of atrial fibrillation with remote controlled magnetic navigation (RMN) has been shown to reduce radiation exposure to patients and physicians compared with conventional manual (MAN) ablation techniques. METHODS: Catheter ablation for atrial fibrillation was performed utilizing RMN in 214 consecutive patients and MAN ablation techniques in 229 patients. We compared the fluoroscopy and procedural times between RMN and MAN catheter ablation of atrial fibrillation...
June 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/28582358/an-interview-with-carmel-clancy-phd-rgn-rmn-bsc-hons-pgcerthe-fph-head-of-the-department-for-mental-health-social-work-and-integrative-medicine-middlesex-university-london-uk
#5
(no author information available yet)
No abstract text is available yet for this article.
April 2017: Journal of Addictions Nursing
https://www.readbyqxmd.com/read/28521980/sulphated-polysaccharide-isolated-from-sargassum-vulgare-characterization-and-hypolipidemic-effects
#6
Rihab Ben Abdallah Kolsi, Hichem Ben Salah, Neila Jardak, Rim Chaaben, Imed Jribi, Abdelfattah El Feki, Tarak Rebai, Kamel Jamoussi, Noureddine Allouche, Cristophe Blecker, Hafedh Belghith, Karima Belghith
A sulphated polysaccharide from brown algae Sargassum vulgare (SVSP) was extracted and examined with respect to chemical, structural characterization and hypolipidemic effects. SVSP consisted mainly of sulphate and total sugars with low levels of lipids and proteins. Its structure was studied by nuclear magnetic resonance (RMN), gas chromatography-mass spectrometry (GC-MS), infra-red spectroscopic, differential scanning calorimetry and X-ray diffraction analysis. Allowing us therefore to revealed that SVSP was composed of glucose, rhamnose, xylose, galactose, mannose and arabinose with XRD pattern that was typical for a semi-crystalline polymer and complexities of the spectra reflected its homogeneous structure...
August 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28419605/radiofrequency-catheter-ablation-of-atrial-fibrillation-electrical-modification-suggesting-transmurality-is-faster-achieved-with-remote-magnetic-catheter-in-comparison-with-contact-force-use
#7
Sok-Sithikun Bun, Anis Ayari, Decebal Gabriel Latcu, Abdelkarim Errahmouni, Nadir Saoudi
BACKGROUND: Remote magnetic navigation (RMN) and contact force (CF) sensing catheters are available technologies for radiofrequency (RF) catheter ablation of atrial fibrillation (AF). Our purpose was to compare time to electrogram (EGM) modification suggesting transmural lesions between RMN and CF-guided AF ablation. METHODS AND RESULTS: A total of 1,008 RF applications were analyzed in 21 patients undergoing RMN (n = 11) or CF-guided ablation (n = 10) for paroxysmal AF...
April 17, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28412654/nigella-sativa-a-traditional-tunisian-herbal-medicine-attenuates-bleomycin-induced-pulmonary-fibrosis-in-a-rat-model
#8
Anouar Abidi, Alexandre Robbe, Nadia Kourda, Saloua Ben Khamsa, Alexandre Legrand
The present study investigated the effects of Nigella sativa oil (NSO) on bleomycin (BLM)-induced lung fibrosis in rats. The rat model of pulmonary fibrosis (PF) was established by intratracheal instillation of BLM, and the effect of 1ml/kg oral NSO treatment once daily observed. The effect of NSO was studied over a period of 50daysusing (1)H RMN analysis on the urine and broncho alveolar lavage fluid (Balf) of the rats. Histopathological (inflammation and fibrosis) and immunohistochemical (TGF-β1 density) changes were evaluated...
June 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28386560/remote-magnetic-versus-manual-navigation-for-radiofrequency-ablation-of-paroxysmal-atrial-fibrillation-long-term-controlled-data-in-a-large-cohort
#9
Vikas Kataria, Benjamin Berte, Yves Vandekerckhove, Rene Tavernier, Mattias Duytschaever
Purpose. We aimed to study long-term outcome after pulmonary vein isolation (PVI) guided by remote magnetic navigation (RMN) and provided comparative data to outcome after manual navigation (MAN). Methods. Three hundred thirty-six patients with symptomatic paroxysmal AF underwent PVI by irrigated point-by-point radiofrequency (RF) ablation (RMN, n = 114 versus MAN, n = 222). Patients were followed up with symptom guided rhythm monitoring for a period up to 43 months. The end point of the study was freedom from repeat ablation after a single procedure and without antiarrhythmic drug treatment (ADT)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28341183/transfer-of-extensor-digiti-minimi-and-extensor-carpi-ulnaris-nerve-branches-to-the-intrinsic-motor-nerve-branches-a-histological-study-on-cadaver
#10
H Namazi, S Haji Vandi
BACKGROUND: In cases of high ulnar and median nerve palsy, result of nerve repair in term of intrinsic muscle recovery is unsatisfactory. Distal nerve transfer can alleviate the regeneration time and improve the results. Transfer of the extensor digiti minimi (EDM) and extensor carpi ulnaris (ECU) nerve branches to the deep branch of ulnar nerve (DBUN)/recurrent branch of median nerve (RMN) at wrist had been used to restore intrinsic hand function but, incomplete recovery occurred. The axon count at the donor nerve has a strong influence on the final results...
June 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28064433/magnetic-vt-study-a-prospective-multicenter-post-market-randomized-controlled-trial-comparing-vt-ablation-outcomes-using-remote-magnetic-navigation-guided-substrate-mapping-and-ablation-versus-manual-approach-in-a-low-lvef-population
#11
Luigi Di Biase, Roderick Tung, Tamás Szili-Torok, J David Burkhardt, Peter Weiss, Rene Tavernier, Adam E Berman, Erik Wissner, William Spear, Xu Chen, Petr Neužil, Jan Skoda, Dhanunjaya Lakkireddy, Bruno Schwagten, Ken Lock, Andrea Natale
PURPOSE: Patients with ischemic cardiomyopathy (ICM) are prone to scar-related ventricular tachycardia (VT). The success of VT ablation depends on accurate arrhythmogenic substrate localization, followed by optimal delivery of energy provided by constant electrode-tissue contact. Current manual and remote magnetic navigation (RMN)-guided ablation strategies aim to identify a reentry circuit and to target a critical isthmus through activation and entrainment mapping during ongoing tachycardia...
January 7, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/27745974/geochemical-characteristics-of-rare-earth-elements-in-the-surface-sediments-from-the-spratly-islands-of-china
#12
Jingxi Li, Chengjun Sun, Li Zheng, Xiaofei Yin, Junhui Chen, Fenghua Jiang
The geochemistry of rare earth elements (REE) in surface sediment from Cuarteron reef (N1), Johnson reef (N2), Hugh reef (N3), Gaven reef (N4), Fiery cross reef (N5), and Subi reef (N6) were firstly studied. The total REE abundance (∑REE) varied from 2.244μg·g(-1) to 21.661μg·g(-1), with an average of 4.667μg·g(-1). The LREE/HREE was from 2.747 to 9.869, with an average of 3.687, which indicated that the light REE was evidently enriched. Fractionation was observed between LREE and HREE. Gd with a negative anomaly was also detected in all of the stations...
January 30, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/27725270/multifunctional-nanogels-with-dual-temperature-and-ph-responsiveness
#13
Loredana Elena Nita, Aurica P Chiriac, Alina Diaconu, Nita Tudorachi, Liliana Mititelu-Tartau
Over the last 10 years, the development of intelligent biomaterials for medical and pharmaceutical applications has attracted growing interest by combining interdisciplinary efforts. Between them nanogels represent one of the most attractive carriers for innovative drug delivery systems. In the present investigation new variants of multi-responsive nanogels have been synthesized by crosslinking poly(itaconic anhydride-co-3,9-divinyl-2,4,8,10-tetraoxaspiro [5.5] undecane) copolymer (having different molar ratios between comonomers) with 1,12-dodecandiol...
December 30, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27646575/membranous-nephropathy-in-the-kidney-allograft
#14
REVIEW
Edward J Filippone, John L Farber
Membranous nephropathy (MN) may occur in a kidney transplant as recurrence of the original disease (rMN) or as a de novo MN (dnMN). rMN often occurs early, within the first year, and often in a mild or subclinical fashion. Recurrence cannot be predicted by clinical features at the time of transplantation. The natural history is increasing proteinuria over time, with less chance for spontaneous remission compared to primary MN (pMN). Antiphospholipase A2 receptor (PLA2R) antibodies should be evaluated in all patients with pMN at the time of transplantation and serially...
November 2016: Clinical Transplantation
https://www.readbyqxmd.com/read/27314679/comparison-of-remote-magnetic-navigation-ablation-and-manual-ablation-of-idiopathic-ventricular-arrhythmia-after-failed-manual-ablation
#15
Mitsuharu Kawamura, Melvin M Scheinman, Zian H Tseng, Byron K Lee, Gregory M Marcus, Nitish Badhwar
PURPOSE: Catheter ablation for idiopathic ventricular arrhythmia (VA) is effective and safe, but efficacy is frequently limited due to an epicardial origin and difficult anatomy. The remote magnetic navigation (RMN) catheter has a flexible catheter design allowing access to difficult anatomy. We describe the efficacy of the RMN for ablation of idiopathic VA after failed manual ablation. METHODS: Among 235 patients with idiopathic VA referred for catheter ablation, we identified 51 patients who were referred for repeat ablation after a failed manual ablation...
January 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/27311989/semi-automatic-measuring-of-arteriovenous-relation-as-a-possible-silent-brain-infarction-risk-index-in-hypertensive-patients
#16
X M Vázquez Dorrego, J M Manresa Domínguez, A Heras Tebar, R Forés, A Girona Marcé, M T Alzamora Sas, P Delgado Martínez, I Riba-Llena, J Ugarte Anduaga, A Beristain Iraola, I Barandiaran Martirena, S M Ruiz Bilbao, P Torán Monserrat
OBJECTIVE: To evaluate the usefulness of a semiautomatic measuring system of arteriovenous relation (RAV) from retinographic images of hypertensive patients in assessing their cardiovascular risk and silent brain ischemia (ICS) detection. METHODS: Semi-automatic measurement of arterial and venous width were performed with the aid of Imedos software and conventional fundus examination from the analysis of retinal images belonging to the 976 patients integrated in the cohort Investigating Silent Strokes in Hypertensives: a magnetic resonance imaging study (ISSYS), group of hypertensive patients...
November 2016: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/27104324/arthroscopic-rotator-cuff-repair-with-or-without-prp-our-experience
#17
Paolo Di Benedetto, Enrico Daniele Di Benedetto, Alessandro Beltrame, Renato Gisonni, Vanni Cainero, Araldo Causero
BACKGROUND AND AIM OF THE WORK: Arthroscopical rotator cuff repair has good results, but the rate of tendon healing is 80% in small tears with a decrease to 30% in large and massive tears. Platelets are an endogenous source of growth factors present during rotator cuff healing. Aim of the work is checking if Cascade Autologous Platelet System may improve rotator cuff healing in small sovraspinatus tears. METHODS: Each patient enrolled in cases  has surgical arthroscopical repair of sovraspinatus  small tear and then treated with intraoperatory Cascade...
2016: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/26969224/a-comparison-of-remote-magnetic-irrigated-tip-ablation-versus-manual-catheter-irrigated-tip-catheter-ablation-with-and-without-force-sensing-feedback
#18
COMPARATIVE STUDY
J Peter Weiss, Heidi T May, Tami L Bair, Brian G Crandall, Michael J Cutler, John D Day, Jeffrey S Osborn, Charles Mallender, T Jared Bunch
BACKGROUND: Remote magnetic navigation (RMN) and contact force (CF) sensing technologies have been utilized in an effort to improve safety and efficacy of catheter ablation. A comparative analysis of the relative short- and long-term outcomes of AF patients has not been performed. As such, we comparatively evaluated the safety and efficacy of these technologies. METHODS: A total of 627 patients who underwent catheter ablation with either a manual irrigated tip catheter: (312, 49...
March 2016: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/26969222/remote-magnetic-navigation-a-focus-on-catheter-ablation-of-ventricular-arrhythmias
#19
REVIEW
Philip Aagaard, Andrea Natale, David Briceno, Hiroshi Nakagawa, Sanghamitra Mohanty, Carola Gianni, J David Burkhardt, Luigi DI Biase
VT ablation is based on percutaneous catheter insertion under fluoroscopic guidance to selectively destroy (i.e., ablate) myocardial tissue regions responsible for the initiation or propagation of ventricular arrhythmias. Although the last decade has witnessed a rapid evolution of ablation equipment and techniques, the control over catheter movement during manual ablation has remained largely unchanged. Moreover, the procedures are long, and require ergonomically unfavorable positions, which can lead to operator fatigue...
March 2016: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/26969220/catheter-ablation-of-ischemic-ventricular-tachycardia-with-remote-magnetic-navigation-stop-vt-multicenter-trial
#20
MULTICENTER STUDY
Jan Skoda, Arash Arya, Fermin Garcia, Edward Gerstenfeld, Francis Marchlinski, Gerhard Hindricks, John Miller, Jan Petru, Lucie Sediva, Qun Sha, Marek Janotka, Milan Chovanec, Petr Waldauf, Petr Neuzil, Vivek Y Reddy
INTRODUCTION: Catheter ablation is an effective treatment of scar-related ventricular tachycardia (VT), but the overall complexity of the procedure has precluded its widespread use. Remote magnetic navigation (RMN) has been shown to facilitate cardiac mapping and ablation of VT in a retrospective series. STOP-VT is the first multicenter, prospective, single-arm and single-procedure study evaluating RMN-based mapping and ablation of post-infarction VT. METHODS: Patients with documented VT and prior MI, in whom an ICD was implanted either for primary or secondary prevention, were recruited from four EU and US centers...
March 2016: Journal of Cardiovascular Electrophysiology
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