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https://www.readbyqxmd.com/read/29679737/malignant-degeneration-of-a-branchial-cyst-a-case-report
#1
Bellakhdhar Mouna, El Abed Wed, Mestiri Sarra, Majdoub Senda, Kermani Wassim, Abdelkefi Mohamed
INTRODUCTION: Malignant degeneration of a branchial cyst is rare [1]. It varies from 4% to 22% [2]. CASE: Report: A74-year-old man presented to our department with a left painless upper neck mass which was excised and histopathology revealed squamous cell carcinoma in a cystic lesion. The appropriate clinical tests and imaging were performed to determine the possible presence of a primary tumor. No primary carcinoma was found. This finding suggests that this was a malignant degeneration of a branchial cyst...
April 18, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29679712/evaluating-the-genotoxicity-of-cellulose-nanofibrils-in-a-co-culture-of-human-lung-epithelial-cells-and-monocyte-derived-macrophages
#2
Célia Ventura, Ana Filipa Lourenço, António Sousa-Uva, Paulo J T Ferreira, Maria João Silva
Cellulose nanofibrils (CNF) are manufactured nanofibres that hold impressive expectations in forest, food, pharmaceutical, and biomedical industries. CNF production and applications are leading to an increased human exposure and thereby it is of utmost importance to assess its safety to health. In this study, we screened the cytotoxic, immunotoxic and genotoxic effects of a CNF produced by TEMPO-mediated oxidation of an industrial bleached Eucalyptus globulus kraft pulp on a co-culture of lung epithelial alveolar (A549) cells and monocyte-derived macrophages (THP-1 cells)...
April 18, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29679602/solubility-enhanced-gmyl6-fused-with-a-hexa-lysine-tag-promotes-the-cytotoxicity-of-human-nk-cells
#3
Juanjuan Liu, Yuanyuan Jin, Xiaozhou Feng, Sen Zou, Guangxin Lv, Zhifei Zhang, Zhaoyong Yang
Goat myosin light chain 6 (gMYL6) is a constituent of certain extracted immunization-induced goat anti-cancer bioactive peptides (ACBPs). However, little is known about its activity onto NK cells which are the basic cellular attackers in cancer immunotherapy for patients with malignancies. Because of the complicated extraction process and low yield of gMYL6 out of the goat ACBPs' mixture, the Nano-flow liquid chromatography and C-terminal polycationic tag expression strategy were used to identify and enrich the peptide to investigate its bioactivity against cancers/tumors...
April 18, 2018: Immunology Letters
https://www.readbyqxmd.com/read/29679600/perinephric-urinoma-secondary-to-malignancy-in-a-pediatric-patient
#4
Julie W Cheng, Ashley Li, David A Chamberlin
Perinephric urinomas commonly arise following traumatic injury or high grade obstruction from kidney stones or lower urinary tract disorders. Not only are spontaneous urinomas rare in the pediatric population, but malignancy presenting with perinephric urinomas have only been described in the adult population. In this case report, we report flank pain from a spontaneous perinephric urinoma as the presenting symptom of lymphoma in a pediatric patient.
April 18, 2018: Urology
https://www.readbyqxmd.com/read/29679523/the-incidence-of-tuberculosis-infection-in-hematopoietic-stem-cell-transplantation-recipients-a-retrospective-cohort-study-from-a-center-in-turkey
#5
Şahika Zeynep Akı, Gülsan Türköz Sucak, Özlem Güzel Tunçcan, Nurdan Köktürk, Esin Şenol
Our results question the role of TST due to low specificity and sensitivity in regions where BCG is mandatory and in patients with hematologic malignancies and suggest that these general guidelines do not seem to apply to all situations. This article is protected by copyright. All rights reserved.
April 21, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29679510/molecular-characteristics-of-multifocal-brain-histiocytic-sarcoma
#6
Florent Marguet, Nicolas Piton, Homa Adle-Biassette, Florence Renaud, Elodie Bohers, Thomas Boyer, Aline Zarea, Stéphane Derrey, Jean Christophe Sabourin, Annie Laquerrière
Histiocytic sarcoma (HS) is a very uncommon malignant proliferation accounting for less than 1% of all neoplasms of hematopoietic and lymphoid tissues. According to the 2008 WHO classification of haematological and lymphoid tumours, diagnosis of HS requires histological and immunohistochemical evidence of histiocytic differentiation [1]. The 2016 Central nervous system (CNS) WHO classification parallels the categories of the corresponding WHO classification of hematopoietic and lymphoid tissues. By definition, diagnosis of HS relies on the expression of at least two of the histiocytic markers, e...
April 21, 2018: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/29679454/primary-lymphoepthelial-carcinoma-of-the-parotid-gland-pictorial-review-of-a-rare-entity
#7
Arani Halder, Jennifer Sommerville, Mitesh Gandhi
Lymphoepithelial carcinoma (LEC) is a rare malignancy of the salivary gland arising from the parotid in 80% of cases. LEC is indistinguishable histologically from more common non-keratinising undifferentiated nasopharyngeal carcinoma (NPC). Up to 40% of patients with primary LEC present with a cervical metastasis and histological assessment of the primary lesion or nodal metastasis may be reported as NPC. The absence of a nasopharyngeal lesion on imaging and endoscopic assessment together with a parotid mass strengthens the case for a LEC...
April 20, 2018: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/29679390/clinically-applicable-irreversible-electroporation-for-eradication-of-microorganisms
#8
Maya Korem, Nahum S Goldberg, Amos Cahan, Matan J Cohen, Isaac Nissenbaum, Allon E Moses
Irreversible electroporation (IRE) damages cell membranes and is used in medicine for non-thermal ablation of malignant tumors. Our aim was to evaluate the antimicrobial effect of IRE. The pathogenic microorganisms, S. aureus, S. pyogenes, E. coli, P. aeruginosa and C. albicans were subjected to IRE. Survival was measured as a function of voltage and the number of pulses applied. Combined use of IRE and oxacillin for eradication of S. aureus was also tested. Log10 reduction of microorganisms positively correlated with the number of applied pulses...
April 21, 2018: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/29679341/biliary-mucinous-cystic-neoplasm-a-classic-presentation-of-a-rare-neoplasm
#9
Shashank Sharma, Kazunari Sasaki, Daniela Allende, Ana Bennett, Federico N Aucejo
Biliary mucinous cystic neoplasms are rare parenchymal neoplasms with a considerable malignant potential. Due to a lack of diagnostic imaging criteria, histopathologic evaluation remains the definitive method of diagnosis. Resection is the treatment of choice. Here, the authors present a case of biliary mucinous neoplasm in a 39-year-old female with the associated radiographic and histopathologic findings.
April 20, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29679299/impact-of-computer-aided-ct-and-pet-analysis-on-non-invasive-t-staging-in-patients-with-lung-cancer-and-atelectasis
#10
Paul Flechsig, Ramin Rastgoo, Clemens Kratochwil, Ole Martin, Tim Holland-Letz, Alexander Harms, Hans-Ulrich Kauczor, Uwe Haberkorn, Frederik L Giesel
PURPOSE: Tumor delineation within an atelectasis in lung cancer patients is not always accurate. When T staging is done by integrated 2-deoxy-2-[18 F]fluoro-D-glucose ([18 F]FDG)-positron emission tomography (PET)/X-ray computer tomography (CT), tumors of neuroendocrine differentiation and slowly growing tumors can present with reduced FDG uptake, thus aggravating an exact T staging. In order to further exhaust information derived from [18 F]FDG-PET/CT, we evaluated the impact of CT density and maximum standardized uptake value (SUVmax) for the classification of different tumor subtypes within a surrounding atelectasis, as well as possible cutoff values for the differentiation between the primary tumor and atelectatic lung tissue...
April 20, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29679253/fever-of-unknown-origin-fuo-cmv-infectious-mononucleosis-or-lymphoma
#11
Burke A Cunha, Karishma Chawla
Fever of unknown origin (FUO) refers to fevers of > 101 °F that persist for > 3 weeks and remain undiagnosed after a focused inpatient or outpatient workup. FUO may be due to infectious, malignant/neoplastic, rheumatic/inflammatory, or miscellaneous disorders. The FUO category determines the focus of the diagnostic workup. In the case presented of an FUO in a young woman, there were clinical findings of both CMV infectious mononucleosis or a lymphoma, e.g., highly elevated ESR, elevated ferritin levels, and elevated ACE level, β-2 microglobulins...
April 20, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29679245/a-systematic-review-of-minimally-invasive-surgery-for-retrorectal-tumors
#12
REVIEW
T G Mullaney, A L Lightner, M Johnston, S R Kelley, D W Larson, E J Dozois
Retrorectal tumors are rare tumors that require resection for symptoms, malignancy and potential malignant transformation. Traditional approaches have included laparotomy, perineal excision or a combination. Multiple minimally invasive techniques are available which have the potential to minimize morbidity and enhance recovery. We performed a systematic review of the literature to determine the feasibility and surgical outcomes of retrorectal tumors approached using minimally invasive surgical techniques. Publications in which adult patients (≥ 18 years) had a minimally invasive approach (laparoscopic or robotic) for resection of a primary retrorectal tumor were included...
April 20, 2018: Techniques in Coloproctology
https://www.readbyqxmd.com/read/29679218/targeting-matrix-metalloproteinases-with-novel-diazepine-substituted-cinnamic-acid-derivatives-design-synthesis-in-vitro-and-in-silico-studies
#13
Dharmender Rathee, Viney Lather, Ajmer Singh Grewal, Harish Dureja
Lung cancer is the notable cause of cancer associated deaths worldwide. Recent studies revealed that the expression of matrix metalloproteinases (MMPs) is extremely high in lung tumors compared with non-malignant lung tissue. MMPs (-2 and -9) play an important part in tumor development and angiogenesis, which suggests that creating potent MMP-2 and -9 inhibitors, should be an important goal in lung cancer therapy. In the present study, an effort has been made to develop new anti-metastatic and anti-invasive agents, wherein a series of novel diazepine substituted cinnamic acid derivatives were designed, synthesized and assayed for their inhibitory activities on MMP-2 and MMP-9...
April 20, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/29679199/-18-f-fdopa-pet-and-mri-characteristics-correlate-with-degree-of-malignancy-and-predict-survival-in-treatment-na%C3%A3-ve-gliomas-a-cross-sectional-study
#14
Chirag B Patel, Elisa Fazzari, Ararat Chakhoyan, Jingwen Yao, Catalina Raymond, Huytram Nguyen, Jasmine Manoukian, Nhung Nguyen, Whitney Pope, Timothy F Cloughesy, Phioanh L Nghiemphu, Johannes Czernin, Albert Lai, Benjamin M Ellingson
INTRODUCTION: To report the potential value of pre-operative 18 F-FDOPA PET and anatomic MRI in diagnosis and prognosis of glioma patients. METHODS: Forty-five patients with a pathological diagnosis of glioma with pre-operative 18 F-FDOPA PET and anatomic MRI were retrospectively examined. The volume of contrast enhancement and T2 hyperintensity on MRI images along with the ratio of maximum 18 F-FDOPA SUV in tumor to normal tissue (T/N SUVmax ) were measured and used to predict tumor grade, molecular status, and overall survival (OS)...
April 20, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29679127/-basic-principles-of-diagnosis-and-treatment-of-gliomas
#15
REVIEW
H-G Wirsching, T Weiss, P Roth, M Weller
BACKGROUND: Traditionally, gliomas were classified based on histopathological features alone. The revised World Health Organization (WHO) classification of tumors of the central nervous system from 2016 integrated molecular features into the histopathological diagnosis. OBJECTIVE: To summarize key aspects of the WHO classification from 2016 and implications for the clinical management of glioma patients. An overview of novel treatment approaches is also provided...
April 20, 2018: Der Nervenarzt
https://www.readbyqxmd.com/read/29679004/the-linc01138-drives-malignancies-via-activating-arginine-methyltransferase-5-in-hepatocellular-carcinoma
#16
Zhe Li, Jiwei Zhang, Xinyang Liu, Shengli Li, Qifeng Wang, Di Chen, Zhixiang Hu, Tao Yu, Jie Ding, Jinjun Li, Ming Yao, Jia Fan, Shenglin Huang, Qiang Gao, Yingjun Zhao, Xianghuo He
Recurrent chromosomal aberrations have led to the discovery of oncogenes or tumour suppressors involved in carcinogenesis. Here we characterized an oncogenic long intergenic non-coding RNA in the frequent DNA-gain regions in hepatocellular carcinoma (HCC), LINC01138 (long intergenic non-coding RNA located on 1q21.2). The LINC01138 locus is frequently amplified in HCC; the LINC01138 transcript is stabilized by insulin like growth factor-2 mRNA-binding proteins 1/3 (IGF2BP1/IGF2BP3) and is associated with the malignant features and poor outcomes of HCC patients...
April 20, 2018: Nature Communications
https://www.readbyqxmd.com/read/29678984/validating-malignant-melanoma-icd-9-cm-codes-in-umbria-asl-napoli-3-sud-and-friuli-venezia-giulia-administrative-healthcare-databases-a-diagnostic-accuracy-study
#17
Massimiliano Orso, Diego Serraino, Iosief Abraha, Mario Fusco, Gianni Giovannini, Paola Casucci, Francesco Cozzolino, Annalisa Granata, Michele Gobbato, Fabrizio Stracci, Valerio Ciullo, Maria Francesca Vitale, Paolo Eusebi, Walter Orlandi, Alessandro Montedori, Ettore Bidoli
OBJECTIVES: To assess the accuracy of International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes in identifying subjects with melanoma. DESIGN: A diagnostic accuracy study comparing melanoma ICD-9-CM codes (index test) with medical chart (reference standard). Case ascertainment was based on neoplastic lesion of the skin and a histological diagnosis from a primary or metastatic site positive for melanoma. SETTING: Administrative databases from Umbria Region, Azienda Sanitaria Locale (ASL) Napoli 3 Sud (NA) and Friuli Venezia Giulia (FVG) Region...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678975/incidence-of-superficial-venous-thrombosis-in-primary-care-and-risk-of-subsequent-venous-thromboembolic-sequelae-a-retrospective-cohort-study-performed-with-routine-healthcare-data-from-the-netherlands
#18
Geert-Jan Geersing, Selma Cazemier, Frans Rutten, David A Fitzmaurice, Arno W Hoes
OBJECTIVES: Recent studies in referred populations of patients with superficial venous thrombosis (SVT) report risks of venous thromboembolic (VTE) sequelae (deep vein thrombosis or pulmonary embolism) as high as 25%. Likely, these estimates are lower in non-referred patients, but large-scale population-based studies are lacking. We aimed to estimate the incidence rate of SVT in primary care and quantify its risk of VTE sequelae. DESIGN: A retrospective cohort study, using International Classification of Primary Care coding (K94...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678899/zfas1-functions-as-an-oncogenic-long-noncoding-rna-in-bladder-cancer
#19
Haifan Yang, Ge Li, Bo Cheng, Rui Jiang
Long non-coding RNA ZFAS1 has been suggested to function as an oncogenic role in the tumorigenesis of human malignant tumors. However, the expression status and biological function of ZFAS1 in bladder cancer is still unknown. Thus, the purpose of this study is to explore the clinical value of ZFAS1 in bladder cancer patient, and the biological function of ZFAS1 in bladder cancer cell. In the present study, we found ZFAS1 expression was increased in bladder cancer tissues compared with paired adjacent normal tissues through analyzing the Cancer Genome Atlas database...
April 20, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29678898/significance-of-aquaporin-aqps-expression-in-the-prognosis-of-gastric-cancer
#20
Saroj Thapa, Mandika Chetry, Kaiyu Huang, Yangpei Peng, Jinsheng Wang, Jiaoni Wang, Yingying Zhou, Yigen Shen, Yangjing Xue, Kangting Ji
Gastric carcinoma is one of the most lethal malignancy at present with leading cause of cancer-related death worldwide. Aquaporins (AQPs) are  family of small, integral membrane proteins, which have been evidenced to play a crucial role in cell migration and proliferation of different cancer cells including gastric cancers. However, the aberrant expression of specific AQPs and its correlation to detect predictive and prognostic significance in gastric cancer remains elusive. In the present study, we comprehensively explored immunohistochemistry based map of protein expression profiles in normal tissues, cancer and cell lines from publicly available Human Protein Atlas database...
April 20, 2018: Bioscience Reports
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