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https://www.readbyqxmd.com/read/27698809/expression-and-prognostic-significance-of-ctbp2-in-human-gliomas
#1
Yong Wang, Shusheng Che, Gang Cai, Yuchao He, Jialei Chen, Wei Xu
Deregulated expression of C-terminal-binding protein 2 (CTBP2) has been observed previously in a number of tumors, such as hepatocellular carcinoma and prostatic cancer, in the colorectal cancer SW480 cell line and in the human embryonic kidney 293 cell line. In the present study, western blot analysis and immunohistochemistry were performed to investigate whether gliomas exhibit deregulated CTBP2 expression. Kaplan-Meier survival analyses were performed to evaluate the associations between CTBP2 expression, clinicopathological data and patient survival in glioma patients...
October 2016: Oncology Letters
https://www.readbyqxmd.com/read/27696081/tyrosine-hydroxylase-expression-in-type-ii-cochlear-afferents-in-mice
#2
Pankhuri Vyas, Jingjing Sherry Wu, Amanda Zimmerman, Paul Fuchs, Elisabeth Glowatzki
Acoustic information propagates from the ear to the brain via spiral ganglion neurons that innervate hair cells in the cochlea. These afferents include unmyelinated type II fibers that constitute 5 % of the total, the majority being myelinated type I neurons. Lack of specific genetic markers of type II afferents in the cochlea has been a roadblock in studying their functional role. Unexpectedly, type II afferents were visualized by reporter proteins induced by tyrosine hydroxylase (TH)-driven Cre recombinase...
September 30, 2016: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/27631825/applying-neurotrophins-to-the-round-window-rescues-auditory-function-and-reduces-inner-hair-cell-synaptopathy-after-noise-induced-hearing-loss
#3
David J Sly, Luke Campbell, Aaron Uschakov, Saieda Tasfia Saief, Matthew Lam, Stephen J O'Leary
HYPOTHESIS: Applying neurotrophins to the round window immediately after a single noise exposure will prevent noise-induced hidden hearing loss. BACKGROUND: Loud noise can eliminate neural connections between inner hair cells and their afferent neurons (thereby diminishing sound perception) without causing a detectable change on audiogram. This phenomenon is termed hidden hearing loss. METHODS: Guinea pigs were exposed for 2 hours to 4 to 8 kHz noise at either 95 or 105 dB SPL...
October 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27615547/genome-wide-association-studies-identify-susceptibility-loci-affecting-respiratory-disease-in-chinese-erhualian-pigs-under-natural-conditions
#4
X Huang, T Huang, W Deng, G Yan, H Qiu, Y Huang, S Ke, Y Hou, Y Zhang, Z Zhang, S Fang, L Zhou, B Yang, J Ren, H Ai, L Huang
Prevalence of swine respiratory disease causes poor growth performance in and serious economic losses to the swine industry. In this study, a categorical trait of enzootic pneumonia-like (EPL) score representing the infection gradient of a respiratory disease, more likely enzootic pneumonia, was recorded in a herd of 332 Chinese Erhualian pigs. According to their EPL scores and the disease effect on weight gains, these pigs were grouped into controls (EPL score ≤ 1) and cases (EPL score > 1). The weight gain of the case group reduced significantly at days 180, 210, 240 and 300 as compared to the control group...
September 12, 2016: Animal Genetics
https://www.readbyqxmd.com/read/27557510/klrg1-restricts-memory-t-cell-antitumor-immunity
#5
Lei Li, Shanshan Wan, Kaixiong Tao, Guobin Wang, Ende Zhao
Killer cell lectin-like receptor subfamily G member 1 (KLRG1) has been found on human memory T lymphocytes. However, the roles of KLRG1 on human T cells especially in tumor microenvironment have not been fully understood. Our results showed KLRG1 expression on T cells significantly increased in tumor microenvironment. KLRG1+ T cells exhibited poor proliferative capacity with decreased effector cytokine production. Meanwhile, KLRG1+ T cells expressed abundant pro-inflammatory cytokines and demonstrated high level of Foxp3 expression...
August 20, 2016: Oncotarget
https://www.readbyqxmd.com/read/27539716/genome-wide-association-analysis-identifies-dcc-as-an-essential-factor-in-the-innervation-of-the-peripheral-vestibular-system-in-inbred-mice
#6
Pezhman Salehi, Anthony Myint, Young J Kim, Marshall X Ge, Joel Lavinsky, Maria K Ho, Amanda L Crow, Charlene Cruz, Maya Monges-Hernadez, Juemei Wang, Jaana Hartiala, Li I Zhang, Hooman Allayee, Aldons J Lusis, Takahiro Ohyama, Rick A Friedman
This study aimed to investigate the genetic causes of vestibular dysfunction. We used vestibular sensory-evoked potentials (VsEPs) to characterize the vestibular function of 35 inbred mouse strains selected from the Hybrid Mouse Diversity Panel and demonstrated strain-dependent phenotypic variation in vestibular function. Using these phenotypic data, we performed the first genome-wide association study controlling for population structure that has revealed two highly suggestive loci, one of which lies within a haplotype block containing five genes (Stard6, 4930503L19Rik, Poli, Mbd2, Dcc) on Chr...
October 2016: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/27534394/discovering-gene-expression-signatures-responding-to-tyrosine-kinase-inhibitor-treatment-in-chronic-myeloid-leukemia
#7
Kihoon Cha, Yi Li, Gwan-Su Yi
BACKGROUND: Tyrosine kinase inhibitor (TKI)-based therapy is a recommended treatment for patients with chronic myeloid leukemia (CML). However, a considerable group of CML patients do not respond well to the TKI therapy. Challenging to overcome this problem, we tried to discover molecular signatures in gene expression profiles to discriminate the responders and non-responders of TKI therapy. METHODS: We collected three microarray datasets of CML patients having total 73 responders and 38 non-responders...
2016: BMC Medical Genomics
https://www.readbyqxmd.com/read/27527066/microrna-regulatory-circuits-in-a-mouse-model-of-inherited-retinal-degeneration
#8
Arpad Palfi, Karsten Hokamp, Stefanie M Hauck, Sebastian Vencken, Sophia Millington-Ward, Naomi Chadderton, Mathew Carrigan, Elod Kortvely, Catherine M Greene, Paul F Kenna, G Jane Farrar
miRNA dysregulation is a hallmark of many neurodegenerative disorders, including those involving the retina. Up-regulation of miR-1/133 and miR-142, and down-regulation of miR-183/96/182 has been described in the RHO-P347S mouse retina, a model for a common form of inherited blindness. High-throughput LC-MS/MS was employed to analyse the protein expression of predicted targets for these miRNAs in RHO-P347S mouse retinas; 133 potential target genes were identified. Pathway over-representation analysis suggests G-protein signaling/visual transduction, and synaptic transmission for miR-1, and transmembrane transport, cell-adhesion, signal transduction and apoptosis for miR-183/96/182 as regulated functions in retina...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27375437/non-image-forming-light-detection-by-melanopsin-rhodopsin-and-long-middlewave-l-w-cone-opsin-in-the-subterranean-blind-mole-rat-spalax-ehrenbergi-immunohistochemical-characterization-distribution-and-connectivity
#9
Gema Esquiva, Aaron Avivi, Jens Hannibal
The blind mole rat, Spalax ehrenbergi, can, despite severely degenerated eyes covered by fur, entrain to the daily light/dark cycle and adapt to seasonal changes due to an intact circadian timing system. The present study demonstrates that the Spalax retina contains a photoreceptor layer, an outer nuclear layer (ONL), an outer plexiform layer (OPL), an inner nuclear layer (INL), an inner plexiform layer (IPL), and a ganglion cell layer (GCL). By immunohistochemistry, the number of melanopsin (mRGCs) and non-melanopsin bearing retinal ganglion cells was analyzed in detail...
2016: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/27340502/ppargc1%C3%AE-gene-dna-methylation-variations-in-human-placenta-mediate-the-link-between-maternal-hyperglycemia-and-leptin-levels-in-newborns
#10
Sandra Côté, Valérie Gagné-Ouellet, Simon-Pierre Guay, Catherine Allard, Andrée-Anne Houde, Patrice Perron, Jean-Patrice Baillargeon, Daniel Gaudet, Renée Guérin, Diane Brisson, Marie-France Hivert, Luigi Bouchard
BACKGROUND: Children exposed to gestational diabetes mellitus (GDM) are at a higher risk of developing obesity and type 2 diabetes. This susceptibility might involve brown adipose tissue (BAT), which is suspected to protect against obesity. The objective of this study is to assess whether fetal exposure to maternal hyperglycemia is associated with DNA methylation variations in genes involved in BAT genesis and activation. METHODS: DNA methylation levels at the PRDM16, BMP7, CTBP2, and PPARGC1α gene loci were measured in placenta samples using bisulfite pyrosequencing in E-21 (n = 133; 33 cases of GDM) and the HumanMethylation450 array in Gen3G (n = 172, all from non-diabetic women) birth cohorts...
2016: Clinical Epigenetics
https://www.readbyqxmd.com/read/27184124/evidence-for-three-genetic-loci-involved-in-both-anorexia-nervosa-risk-and-variation-of-body-mass-index
#11
A Hinney, M Kesselmeier, S Jall, A-L Volckmar, M Föcker, J Antel, I M Heid, T W Winkler, S F A Grant, Y Guo, A W Bergen, W Kaye, W Berrettini, H Hakonarson, B Herpertz-Dahlmann, M de Zwaan, W Herzog, S Ehrlich, S Zipfel, K M Egberts, R Adan, M Brandys, A van Elburg, V Boraska Perica, C S Franklin, M H Tschöp, E Zeggini, C M Bulik, D Collier, A Scherag, T D Müller, J Hebebrand
The maintenance of normal body weight is disrupted in patients with anorexia nervosa (AN) for prolonged periods of time. Prior to the onset of AN, premorbid body mass index (BMI) spans the entire range from underweight to obese. After recovery, patients have reduced rates of overweight and obesity. As such, loci involved in body weight regulation may also be relevant for AN and vice versa. Our primary analysis comprised a cross-trait analysis of the 1000 single-nucleotide polymorphisms (SNPs) with the lowest P-values in a genome-wide association meta-analysis (GWAMA) of AN (GCAN) for evidence of association in the largest published GWAMA for BMI (GIANT)...
May 17, 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27132232/changes-in-ganglion-cells-during-retinal-degeneration
#12
Susmita Saha, Ursula Greferath, Kirstan A Vessey, David B Grayden, Anthony N Burkitt, Erica L Fletcher
Inherited retinal degeneration such as retinitis pigmentosa (RP) is associated with photoreceptor loss and concomitant morphological and functional changes in the inner retina. It is not known whether these changes are associated with changes in the density and distribution of synaptic inputs to retinal ganglion cells (RGCs). We quantified changes in ganglion cell density in rd1 and age-matched C57BL/6J-(wildtype, WT) mice using the immunocytochemical marker, RBPMS. Our data revealed that following complete loss of photoreceptors, (∼3months of age), there was a reduction in ganglion cell density in the peripheral retina...
August 4, 2016: Neuroscience
https://www.readbyqxmd.com/read/26871283/pinin-interacts-with-c-terminal-binding-proteins-for-rna-alternative-splicing-and-epithelial-cell-identity-of-human-ovarian-cancer-cells
#13
Yanli Zhang, Jamie Sui-Lam Kwok, Pui-Wah Choi, Minghua Liu, Junzheng Yang, Margit Singh, Shu-Kay Ng, William R Welch, Michael G Muto, Stephen Kw Tsui, Stephen P Sugrue, Ross S Berkowitz, Shu-Wing Ng
Unlike many other human solid tumors, ovarian tumors express many epithelial markers at a high level for cell growth and local invasion. The phosphoprotein Pinin plays a key role in epithelial cell identity. We showed that clinical ovarian tumors and ovarian cancer cell lines express a high level of Pinin when compared with normal ovarian tissues and immortalized normal ovarian surface epithelial cell lines. Pinin co-localized and physically interacted with transcriptional corepressor C-terminal binding proteins, CtBP1 and CtBP2, in the nuclei of cancer cells...
March 8, 2016: Oncotarget
https://www.readbyqxmd.com/read/26788097/ctbp2-overexpression-is-associated-with-tumorigenesis-and-poor-clinical-outcome-of-prostate-cancer
#14
Changwen Zhang, Shuanghui Li, Baomin Qiao, Kuo Yang, Ranlu Liu, Baojie Ma, Yan Liu, Zhihong Zhang, Yong Xu
INTRODUCTION: The aim of the study was to evaluate the expression of CtBP2 in prostate cancer and to determine its relationship with clinicopathologic parameters. MATERIAL AND METHODS: The expression of CtBP2 in 119 prostate cancer tissues and 41 normal tissues was examined by qPCR and Western blot analysis, and the results were correlated with clinicopathologic parameters. RESULTS: CtBP2 expression in prostate cancer tissues was higher than that in normal samples...
December 10, 2015: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/26744317/down-regulation-of-the-zinc-finger-homeobox-protein-tshz2-releases-gli1-from-the-nuclear-repressor-complex-to-restore-its-transcriptional-activity-during-mammary-tumorigenesis
#15
Miho Riku, Shingo Inaguma, Hideaki Ito, Takumi Tsunoda, Hiroshi Ikeda, Kenji Kasai
Although breast cancer is one of the most common malignancies, the molecular mechanisms underlying its development and progression are not fully understood. To identify key molecules involved, we screened publicly available microarray datasets for genes differentially expressed between breast cancers and normal mammary glands. We found that three of the genes predicted in this analysis were differentially expressed among human mammary tissues and cell lines. Of these genes, we focused on the role of the zinc-finger homeobox protein TSHZ2, which is down-regulated in breast cancer cells...
February 2, 2016: Oncotarget
https://www.readbyqxmd.com/read/26681554/ctbp2-regulates-tgf%C3%AE-2-induced-epithelial-mesenchymal-transition-through-notch-signaling-pathway-in-lens-epithelial-cells
#16
Guowei Zhang, Lihua Kang, Jia Chen, Ying Xue, Mei Yang, Bai Qin, Ling Yang, Junfang Zhang, Hong Lu, Huaijin Guan
BACKGROUND: Epithelial-mesenchymal transition (EMT) of human lens epithelial cells (LECs) contributes to posterior capsule opacification (PCO). C-terminal binding protein 2 (CtBP2) has been reported to be essential in EMT and embryonic development. However, the function of CtBP2 in EMT of LECs is unknown. The goal of this study was to investigate the role of CtBP2 through Notch signaling in transforming growth factor β2 (TGFβ2)-induced EMT in LECs. METHODS: The human LEC line SRA01/04 was cultured in the presence of TGFβ2 for different periods of time or with γ-Secretase Inhibitor IX (DAPT), a specific inhibitor of Notch receptor cleavage, for 24 h, utilizing plasmid-based method...
December 17, 2015: Current Eye Research
https://www.readbyqxmd.com/read/26639016/fgf22-protects-hearing-function-from-gentamycin-ototoxicity-by-maintaining-ribbon-synapse-number
#17
Shuna Li, Lihua Hang, Yongming Ma
Inner hair cell (IHC) ribbon synapses of cochlea play important role in transmitting sound signal into auditory nerve and are sensitive to ototoxicity. However, ototoxic damage of ribbon synapses is not understood clearly. Roles of fibroblast growth factor 22 (FGF22) on synapse formation were explored under gentamycin ototoxicity. 6-week-old mice were injected intraperitoneally once daily with 50-150 mg/kg gentamicin for 10 days. Immunostaining with anti- GluR2&3/CtBP2 was used to estimate the number of ribbon synapses in the cochlea...
February 2016: Hearing Research
https://www.readbyqxmd.com/read/26087114/morphological-correlates-of-hearing-loss-after-cochlear-implantation-and-electro-acoustic-stimulation-in-a-hearing-impaired-guinea-pig-model
#18
Lina A J Reiss, Gemaine Stark, Anh T Nguyen-Huynh, Kayce A Spear, Hongzheng Zhang, Chiemi Tanaka, Hongzhe Li
Hybrid or electro-acoustic stimulation (EAS) cochlear implants (CIs) are designed to provide high-frequency electric hearing together with residual low-frequency acoustic hearing. However, 30-50% of EAS CI recipients lose residual hearing after implantation. The objective of this study was to determine the mechanisms of EAS-induced hearing loss in an animal model with high-frequency hearing loss. Guinea pigs were exposed to 24 h of noise (12-24 kHz at 116 dB) to induce a high-frequency hearing loss. After recovery, two groups of animals were implanted (n = 6 per group), with one group receiving chronic acoustic and electric stimulation for 10 weeks, and the other group receiving no stimulation during this time frame...
September 2015: Hearing Research
https://www.readbyqxmd.com/read/25944056/ctbp2-modulates-nurd-mediated-deacetylation-of-h3k27-and-facilitates-prc2-mediated-h3k27me3-in-active-embryonic-stem-cell-genes-during-exit-from-pluripotency
#19
Tae Wan Kim, Byung-Hee Kang, Hyonchol Jang, Sojung Kwak, Jihoon Shin, Hyunsoo Kim, Sang-Eun Lee, Soon-Min Lee, Jong-Hyuk Lee, Jae-Hwan Kim, Seon-Young Kim, Eun-Jung Cho, Ju Han Kim, Keun Soo Park, Jeong-Hwan Che, Dong Wook Han, Min Jueng Kang, Eugene C Yi, Hong-Duk Youn
For cells to exit from pluripotency and commit to a lineage, the circuitry of a core transcription factor (CTF) network must be extinguished in an orderly manner through epigenetic modifications. However, how this choreographed epigenetic remodeling at active embryonic stem cell (ESC) genes occurs during differentiation is poorly understood. In this study, we demonstrate that C-terminal binding protein 2 (Ctbp2) regulates nucleosome remodeling and deacetylation (NuRD)-mediated deacetylation of H3K27 and facilitates recruitment of polycomb repressive complex 2 (PRC2)-mediated H3K27me3 in active ESC genes for exit from pluripotency during differentiation...
August 2015: Stem Cells
https://www.readbyqxmd.com/read/25943993/mechanism-study-of-peptide-gmbp1-and-its-receptor-grp78-in-modulating-gastric-cancer-mdr-by-itraq-based-proteomic-analysis
#20
Xiaojuan Wang, Yani Li, Guanghui Xu, Muhan Liu, Lin Xue, Lijuan Liu, Sijun Hu, Ying Zhang, Yongzhan Nie, Shuhui Liang, Biaoluo Wang, Jie Ding
BACKGROUND: Multidrug resistance (MDR) is a major obstacle to the treatment of gastric cancer (GC). Using a phage display approach, we previously obtained the peptide GMBP1, which specifically binds to the surface of MDR gastric cancer cells and is subsequently internalized. Furthermore, GMBP1 was shown to have the potential to reverse the MDR phenotype of gastric cancer cells, and GRP78 was identified as the receptor for this peptide. The present study aimed to investigate the mechanism of peptide GMBP1 and its receptor GRP78 in modulating gastric cancer MDR...
2015: BMC Cancer
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