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https://www.readbyqxmd.com/read/28918170/lifestyle-predictors-of-obese-and-non-obese-patients-with-nonalcoholic-fatty-liver-disease-a-cross-sectional-study
#1
Joo Hee Kwak, Dae Won Jun, Seung Min Lee, Yong Kyun Cho, Kang Nyeong Lee, Hang Lak Lee, Oh Young Lee, Ho Soon Choi, Byung Chul Yoon
BACKGROUND & AIMS: Most people with nonalcoholic fatty liver disease (NAFLD) are obese, and they usually eat more while being less physically active as compared to healthy individuals. However, little is known about the lifestyle patterns of non-obese or obese patients with NAFLD. The aim of this study was to investigate nutrition components and behavioral differences between non-obese and obese patients with NAFLD. METHODS: This is a cross-sectional study comprising of 209 patients...
August 30, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28915225/physical-activity-not-sedentary-time-predicts-dual-energy-x-ray-absorptiometry-measured-adiposity-age-5-to-19-years
#2
Kathleen F Janz, Piroska Boros, Elena M Letuchy, Soyang Kwon, Trudy L Burns, Steven M Levy
PURPOSE: To examine the associations among physical activity (PA), sedentary time (SED), and TV viewing (TV) with fat mass (FAT) and visceral adipose tissue mass (VAT) from childhood through adolescence (5-19 yr). METHODS: Participants in the Iowa Bone Development Study (n = 230 males and 233 females) were examined at ages 5, 8, 11, 13, 15, 17, and 19 yr. Accelerometers measured moderate- or vigorous-intensity PA (MVPA; min·d), light-intensity PA (LPA; min·d), and SED (h·d)...
October 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28912902/effects-of-dapagliflozin-on-body-composition-and-liver-tests-in-patients-with-nonalcoholic-steatohepatitis-associated-with-type-2-diabetes-mellitus-a-prospective-open-label-uncontrolled-study
#3
Hiroshi Tobita, Shuichi Sato, Tatsuya Miyake, Shunji Ishihara, Yoshikazu Kinoshita
BACKGROUND: Nonalcoholic steatohepatitis (NASH) is an active form of nonalcoholic fatty liver disease. Risk factors for NASH include type 2 diabetes mellitus (T2DM) and obesity. Sodium-glucose cotransporter 2 (SGLT2) inhibitors used to treat T2DM prevent glucose reabsorption in the kidney and increase glucose urinary excretion. Dapagliflozin is a potent, selective SGLT2 inhibitor that reduces hyperglycemia in patients with T2DM and has been demonstrated to reduce some complications associated with NASH in rodent models...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/28912305/effects-of-liraglutide-on-weight-loss-fat-distribution-and-%C3%AE-cell-function-in-obese-subjects-with-prediabetes-or-early-type-2-diabetes
#4
Francesca Santilli, Paola G Simeone, Maria T Guagnano, Marika Leo, Marica T Maccarone, Augusto Di Castelnuovo, Cristina Sborgia, Riccardo C Bonadonna, Ermanno Angelucci, Virginia Federico, Stefano Cianfarani, Lamberto Manzoli, Giovanni Davì, Armando Tartaro, Agostino Consoli
OBJECTIVE: Obesity is associated with an increased risk of type 2 diabetes and cardiovascular complications. The risk depends significantly on adipose tissue distribution. Liraglutide, a glucagon-like peptide 1 analog, is associated with weight loss, improved glycemic control, and reduced cardiovascular risk. We determined whether an equal degree of weight loss by liraglutide or lifestyle changes has a different impact on subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) in obese subjects with prediabetes or early type 2 diabetes...
September 14, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28911004/inherent-aerobic-capacity-dependent-differences-in-breast-carcinogenesis
#5
Henry J Thompson, Lee W Jones, Lauren G Koch, Steven L Britton, Elizabeth S Neil, John N McGinley
Although regular physical activity is associated with improvement in aerobic capacity and lower breast cancer risk, there are heritable sets of traits that affect improvement in aerobic capacity in response to physical activity. Although aerobic capacity segregates risk for a number of chronic diseases, the effect of the heritable component on cancer risk has not been evaluated. Therefore, we investigated breast carcinogenesis in rodent models of heritable fitness in the absence of induced physical activity...
September 1, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28910301/prevalence-of-overweight-obesity-abdominal-obesity-and-obesity-related-risk-factors-in-southern-china
#6
Lihua Hu, Xiao Huang, Chunjiao You, Juxiang Li, Kui Hong, Ping Li, Yanqing Wu, Qinhua Wu, Zengwu Wang, Runlin Gao, Huihui Bao, Xiaoshu Cheng
OBJECTIVES: The purpose of this study is to assess the prevalence of overweight/obesity, abdominal obesity and obesity-related risk factors in southern China. METHODS: A cross-sectional survey of 15,364 participants aged 15 years and older was conducted from November 2013 to August 2014 in Jiangxi Province, China, using questionnaire forms and physical measurements. The physical measurements included body height, weight, waist circumference (WC), body fat percentage (BFP) and visceral adipose index (VAI)...
2017: PloS One
https://www.readbyqxmd.com/read/28906398/abdominal-fat-distribution-measured-using-computed-tomography-is-associated-with-an-increased-risk-of-colorectal-adenoma-in-men
#7
Il-Kook Seo, Beom Jin Kim, Bomin Kim, Chang Hwan Choi, Jeong Wook Kim, Jae Gyu Kim, Se Kyung Chang, Hyun Kang
A few studies have shown inconsistent results regarding the association between the visceral fat proportion and colorectal adenomas. We aimed to investigate the association between abdominal fat distribution measured by computed tomography (CT) and colon adenoma.A total of 336 participants underwent physical examination, blood tests, colonoscopy, and abdominal computed tomography at Chung-Ang University Hospital. The associations between the obesity indicies (body mass index, visceral fat area (VFA), subcutaneous fat area (SFA), VFA-to-SFA ratio (VFA/SFA), and colorectal adenomas were evaluated...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28900540/treatment-of-diabetic-mice-with-the-sglt2-inhibitor-ta-1887-antagonizes-diabetic-cachexia-and-decreases-mortality
#8
Taichi Sugizaki, Shunshun Zhu, Ge Guo, Akiko Matsumoto, Jiabin Zhao, Motoyoshi Endo, Haruki Horiguchi, Jun Morinaga, Zhe Tian, Tsuyoshi Kadomatsu, Keishi Miyata, Hiroshi Itoh, Yuichi Oike
A favorable effect of an inhibitor of the sodium-glucose cotransporter 2 (SGLT2i) on mortality of diabetic patients was recently reported, although mechanisms underlying that effect remained unclear. Here, we examine SGLT2i effects on survival of diabetic mice and assess factors underlying these outcomes. To examine SGLT2i treatment effects in a model of severe diabetes, we fed genetically diabetic db/db mice a high-fat diet and then assessed outcomes including diabetic complications between SGLT2i TA-1887-treated and control mice...
2017: NPJ Aging and Mechanisms of Disease
https://www.readbyqxmd.com/read/28900399/acacetin-from-traditionally-used-saussurea-involucrata-kar-et-kir-suppressed-adipogenesis-in-3t3-l1-adipocytes-and-attenuated-lipid-accumulation-in-obese-mice
#9
Chian-Jiun Liou, Shu-Ju Wu, Li-Chen Chen, Kuo-Wei Yeh, Chih-Ying Chen, Wen-Chung Huang
Acacetin, a flavone that can be isolated from the Saussurea involucrata plant, has anti-tumor and anti-inflammatory properties that ameliorate airway hyperresponsiveness in asthmatic mice. This study investigated whether acacetin has anti-adipogenic effects in 3T3-L1 adipocytes and whether it regulates the inflammatory response in adipocytes and macrophages. It also investigated whether acacetin ameliorates lipid accumulation in high-fat diet- (HFD) induced obese mice. Differentiated 3T3-L1 cells were treated with acacetin...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28895929/effects-of-oral-administration-of-silymarin-in-a-juvenile-murine-model-of-non-alcoholic-steatohepatitis
#10
Veronica Marin, Silvia Gazzin, Sabrina E Gambaro, Matteo Dal Ben, Sonia Calligaris, Monica Anese, Alan Raseni, Claudio Avellini, Pablo J Giraudi, Claudio Tiribelli, Natalia Rosso
The increasing prevalence of non-alcoholic fatty liver disease (NAFLD) in adolescents is challenging the global care system. No therapeutic strategies have been defined so far, and changes in the lifestyle remain the only alternative. In this study, we assessed the protective effects of silymarin in a juvenile non-alcoholic steatohepatitis (NASH) model and the in vitro effects on fat-laden human hepatocytes. C57Bl/6 mice were exposed to HFHC diet immediately after weaning. After eight weeks, animals showed histological signs of NASH...
September 12, 2017: Nutrients
https://www.readbyqxmd.com/read/28895079/visceral-adipose-tissue-as-a-risk-factor-for-diabetes-mellitus-in-patients-with-chronic-pancreatitis-a-cross-sectional-observational-study
#11
K V S Hari Kumar, Rahul Sharma, Manish Manrai, A K Sood
INTRODUCTION: Visceral adipose tissue (VAT) is a risk factor for diabetes and we investigated the amount of VAT in patients with chronic pancreatitis (CP). METHODS: Serial patients with CP seen between January 2015 and June 2016 were included in this cross-sectional, observational study. The study population was divided into alcoholic CP (group 1; N = 67) and tropical CP (group 2; N = 35). VAT was estimated using bioelectric impedance analysis (BIA) and dual energy X-ray absorptiometry (DEXA) methods...
September 11, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28894290/association-of-proton-density-fat-fraction-in-adipose-tissue-with-imaging-based-and-anthropometric-obesity-markers-in-adults
#12
D Franz, D Weidlich, F Freitag, C Holzapfel, T Drabsch, T Baum, H Eggers, A Witte, E J Rummeny, H Hauner, D C Karampinos
BACKGROUND/OBJECTIVES: The purpose of this study was to examine the relationship of the proton density fat fraction (PDFF), measured by magnetic resonance imaging (MRI), of supraclavicular and gluteal adipose tissue with subcutaneous and visceral adipose tissue (SAT and VAT) volumes, liver fat fraction and anthropometric obesity markers. The supraclavicular fossa was selected as a typical location where brown adipocytes may be present in humans and the gluteal region was selected as a typical location enclosing primarily white adipocytes...
August 14, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28893558/the-effects-of-chronic-testosterone-administration-on-body-weight-food-intake-and-fat-weight-were-age-dependent
#13
Takeshi Iwasa, Toshiya Matsuzaki, Mayila Yiliyasi, Kiyohito Yano, Minoru Irahara
Previously, we showed that chronic testosterone administration increased body weight (BW) and food intake (FI), but did not alter fat weight, in young female rats. To examine our hypothesis that the effects of androgens on BW, FI and body composition might be age-dependent, the effects of chronic testosterone administration were evaluated in rats of different ages; i.e., young and middle-aged rats. Although chronic testosterone administration increased BW gain, FI, and feed efficiency in both young and middle-aged rats, it increased visceral fat weight in middle-aged rats, but not in young rats...
September 8, 2017: Steroids
https://www.readbyqxmd.com/read/28891931/beneficial-effects-of-common-bean-on-adiposity-and-lipid-metabolism
#14
Henry J Thompson, John N McGinley, Elizabeth S Neil, Mark A Brick
In developed countries which are at the epicenter of the obesity pandemic, pulse crop consumption is well below recommended levels. In a recent systematic review and meta-analysis of 21 randomized controlled clinical trials, pulse consumption was associated with improved weight control and reduced adiposity, although the underlying mechanisms were a matter of speculation. Common bean (Phaseolus vulgaris L.) is the most widely consumed pulse crop and was the focus of this investigation. Using outbred genetic models of dietary induced obesity resistance and of dietary induced obesity sensitivity in the rat, the impact of bean consumption was investigated on the efficiency with which consumed food was converted to body mass (food efficiency ratio), body fat accumulation, adipocyte morphometrics, and patterns of protein expression associated with lipid metabolism...
September 9, 2017: Nutrients
https://www.readbyqxmd.com/read/28889156/oxidative-damage-and-associated-inflammatory-risk-factors-in-obese-emirati-women-body-mass-index-versus-waist-circumference
#15
Salah Gariballa, Juma Alkaabi, Javed Yasin, Awad Al Essa
OBJECTIVES: To establish whether body mass index (BMI) or waist circumference (WC) is a better predictor of cardio metabolic risk factors that are associated with increased visceral fat among obese women from the United Arab Emirates (UAE). METHODS: In this  cross-sectional study, 333 obese subjects visiting community health centers in Al Ain city, UAE, were recruited between 2012 and 2015. After a written consent subjects had anthropometric, clinical and biochemical measurements...
September 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28887474/body-fat-distribution-and-the-risk-of-incident-metabolic-syndrome-a-longitudinal-cohort-study
#16
Hyuktae Kwon, Donghee Kim, Joo Sung Kim
The effect of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) area on metabolic syndrome (MS) has been debated. We aimed to evaluate the effects of VAT and SAT on the incidence of MS and its components in a large and apparently healthy Asian population. We performed a longitudinal cohort study of 1,964 subjects who received health screenings over a 5-year follow-up period; 317 incidents of MS (16.1%) were observed during a median follow-up of 4.5 years. The VAT area was significantly associated with a higher incidence of MS; the adjusted HR for incident MS per 1 SD of VAT was 1...
September 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28885568/emotion-based-cognition-in-mice-is-differentially-influenced-by-dose-and-chemical-form-of-dietary-docosahexaenoic-acid
#17
Kevin D Laugero, Yuriko Adkins, Bruce E Mackey, Darshan S Kelley
Docosahexaenoic acid (DHA) is a major constituent, and primary omega-3 fatty acid, in the brain. Evidence suggests that DHA consumption may promote cognitive functioning and prevent cognitive decline, and these effects may be particularly relevant in the context of fear or stress. However, the potency and efficacy of dietary DHA may depend on the form of DHA (e.g., phospholipid; PL vs. triglyceride; TG). In this study, we compared in mice the effects of consuming PL and TG forms of DHA on associative, avoidance (fear) based learning and memory...
September 8, 2017: Nutrients
https://www.readbyqxmd.com/read/28885548/novel-insights-into-the-adipokinome-of-obese-and-obese-diabetic-mouse-models
#18
Birgit Knebel, Simon Goeddeke, Gereon Poschmann, Daniel F Markgraf, Sylvia Jacob, Ulrike Nitzgen, Waltraud Passlack, Christina Preuss, Hans-Dieter Dicken, Kai Stühler, Sonja Hartwig, Stefan Lehr, Jorg Kotzka
The group of adipokines comprises hundreds of biological active proteins and peptides released from adipose tissue. Alterations of those complex protein signatures are suggested to play a crucial role in the pathophysiology of multifactorial, metabolic diseases. We hypothesized that also the pathophysiology of type-2-diabetes is linked to the dysregulation of the adipocyte secretome. To test this, we investigated mouse models with monogenic defects in leptin signaling which are susceptible to adipositas (C57BL/6 Cg-Lep(ob) (obob)) or adipositas with diabetes (C57BL/KS Cg-Lepr(db) (dbdb)) according to their genetic background...
September 8, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28884865/physical-training-improves-visceral-adipose-tissue-health-by-remodelling-extracellular-matrix-in-rats-with-estrogen-absence-a-gene-expression-analysis
#19
Fernanda O Duarte, Camila do Valle Gomes-Gatto, Jorge C Oishi, Anderson Diogo de S Lino, Uliana S Stotzer, Maria Fernanda C Rodrigues, Guilherme H Gatti da Silva, Heloisa S Selistre-de-Araújo
Adipose tissue development is associated with modifications involving extracellular matrix remodelling, and metalloproteinases play a significant role in this process. Reduced circulating sexual hormones cause impacts on the size, morphology and functions of the adipose tissue, increasing susceptibility to diseases. This study investigated whether exercise training may be an alternative strategy to combat the effects promoted by estrogen decay through modulation in gene expression patterns in the extracellular matrix (ECM) of visceral adipose tissue of ovariectomized rats...
September 8, 2017: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/28884861/use-of-idxa-spine-scans-to-evaluate-total-and-visceral-abdominal-fat
#20
J W Bea, C-H Hsu, R M Blew, A P Irving, B J Caan, M L Kwan, I Abraham, S B Going
OBJECTIVES: Abdominal fat may be a better predictor than body mass index (BMI) for risk of metabolically-related diseases, such as diabetes, cardiovascular disease, and some cancers. We sought to validate the percent fat reported on dual energy X-ray absorptiometry (DXA) regional spine scans (spine fat fraction, SFF) against abdominal fat obtained from total body scans using the iDXA machine (General Electric, Madison, WI), as previously done on the Prodigy model. METHODS: Total body scans and regional spine scans were completed on the same day (N = 50)...
September 8, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
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