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https://www.readbyqxmd.com/read/29783208/the-role-of-hydrogen-sulfide-in-the-progression-mechanisms-of-non-alcoholic-steatohepatitis-and-chronic-kidney-disease
#1
Oksana S Khukhlina, Igor V Gerush, Alona A Antoniv, Olha Ye Mandryk, Tamara G Kopchuk, Svitlana P Melnychuk, Zoriana Ia Kotsiubiichuk
OBJECTIVE: Introduction: The steady increase in the incidence of non-alcoholic steatohepatitis (NASH) on the background of obesity and chronic kidney disease (CKD) in people of working age in Ukraine. The aim: To establish the role of hydrogen sulfide in the mechanisms of mutual burden and progression of non-alcoholic steatohepatitis and chronic kidney disease in patients with obesity. PATIENTS AND METHODS: Materials and methods: 114 patients with NASH were examined on the background of obesity of І-ІІ degree, including: 52 patients with NASH (group 1) (without accompanying CKD), 62 patients with NASH with a comorbid CKD І-ІІ degree (group 2)...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783061/enhanced-extinction-of-aversive-memories-in-mice-lacking-sparc-related-protein-containing-immunoglobulin-domains-1-spig1-fstl4
#2
Ryoko Suzuki, Akihiro Fujikawa, Yukio Komatsu, Kazuya Kuboyama, Naomi Tanga, Masaharu Noda
Brain-derived neurotrophic factor (BDNF) plays an important role in synaptic plasticity related to learning and memory. We previously reported that SPARC-related protein-containing immunoglobulin domains 1 (SPIG1, also known as Follistatin-like protein 4, FSTL4) binds to pro-BDNF and negatively regulates BDNF maturation; however, its neurological functions, particularly in learning and memory, have not yet been elucidated. We herein examined the electrophysiological and behavioral phenotypes of Spig1-knockout (Spig1-KO) mice...
May 18, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29782935/vitamin-d-status-and-the-risk-of-type-2-diabetes-the-melbourne-collaborative-cohort-study
#3
Alicia K Heath, Elizabeth J Williamson, Allison M Hodge, Peter R Ebeling, Darryl W Eyles, David Kvaskoff, Kerin O'Dea, Graham G Giles, Dallas R English
AIMS: Inverse associations between vitamin D status and risk of type 2 diabetes observed in epidemiological studies could be biased by confounding and reverse causality. We investigated the prospective association between vitamin D status and type 2 diabetes and the possible role of reverse causality. METHODS: We conducted a case-cohort study within the Melbourne Collaborative Cohort Study (MCCS), including a random sample of 628 participants who developed diabetes and a sex-stratified random sample of the cohort (n=1,884)...
May 18, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29782841/alternative-splicing-of-gnrh2-and-gnrh2-associated-peptide-plays-roles-in-gonadal-differentiation-of-the-rice-field-eel-monopterus-albus
#4
Ke Feng, Hongrui Luo, Mingxi Hou, Yongming Li, Ji Chen, Zuoyan Zhu, Wei Hu
The rice field eel, Monopterus albus, is a protogynous hermaphrodite fish, in which the gonads are initially female ovaries which then transform into male testes. The exact mechanisms governing sex reversal in the rice field eel are unknown. In this study, a novel alternative splicing variant of GnRH2 (GnRH2-SV), retaining the second intron, was discovered in the gonad of the rice field eel. Compared to GnRH2, GnRH2-SV may give rise to a novel truncated GnRH2-associated peptide (New GAP2). The normal transcript of GnRH2 was primarily expressed in the brain, and could also be detected in the liver, spleen, ovary, and testis...
May 18, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29782468/potential-role-of-gut-microbiota-in-als-pathogenesis-and-possible-novel-therapeutic-strategies
#5
Letizia Mazzini, Luca Mogna, Fabiola De Marchi, Angela Amoruso, Marco Pane, Irene Aloisio, Nicole Bozzi Cionci, Francesca Gaggìa, Ausiliatrice Lucenti, Enrica Bersano, Roberto Cantello, Diana Di Gioia, Giovanni Mogna
BACKGROUND: Recent preclinical studies suggest that dysfunction of gastrointestinal tract may play a role in amyotrophic lateral sclerosis (ALS) pathogenesis through a modification of the gut microbiota brain axis. Our study is the first focused on microbiota analysis in ALS patients. AIM: Our aim was to study the main human gut microbial groups and the overall microbial diversity in ALS and healthy subjects. Moreover we have examined the influence of a treatment with a specific bacteriotherapy composed of Lactobacillus strains (Lactobacillus fermentum, Lactobacillus delbrueckii, Lactobacillus plantarum, Lactobacillus salivarius) acting on the gastrointestinal barrier...
May 18, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29782310/putative-gonadotropin-releasing-hormone-agonist-therapy-and-dementia-an-application-of-medicare-hospitalization-claims-data
#6
Mark A Smith, Richard L Bowen, Richard Q Nguyen, George Perry, Craig S Atwood, Alfred A Rimm
BACKGROUND: Estrogen and hormone replacement therapies to reduce Alzheimer's disease (AD) have yielded conflicting results. However, this study proposes that the well-characterized increase in serum gonadotropins following menopause or andropause are accountable for the increased risk of developing AD among the elderly population. OBJECTIVE: To determine the role of gonadotropins in the development of AD and investigate gonadotropin-releasing hormone (GnRH) agonist therapy as a potential preventative and/or disease-modifying approach to AD management...
May 16, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29781671/breed-prevalence-of-canine-lymphoma-in-south-africa
#7
Liesl J Van Rooyen, Emma Hooijberg, Fred Reyers
Lymphoma is a common haematopoietic neoplasm in dogs. Several breeds have been shown to have a predisposition to lymphoma; however, very little information exists regarding the South African dog population. This study assessed whether any breed had increased odds of developing lymphoma compared with others, and also investigated the effects of age, sex and neutering status on disease prevalence. Two study populations and their corresponding reference populations were studied retrospectively. Odds ratios (ORs) for lymphoma in 49 dog breeds, together with their 95% confidence intervals (CI), were calculated...
March 8, 2018: Journal of the South African Veterinary Association
https://www.readbyqxmd.com/read/29781541/the-two-rules-of-speciation-in-species-with-young-sex-chromosomes
#8
Dmitry A Filatov
The two "rules of speciation", Haldane's rule (HR) and the large-X effect (LXE), are thought to be caused by recessive species incompatibilities exposed in the phenotype due to the hemizygosity of X-linked genes in the heterogametic sex. Thus, the reports of HR and the LXE in species with recently evolved non- or partially-degenerate Y-chromosomes, such as Silene latifolia and its relatives, were surprising. Here I argue that rapid species-specific degeneration of Y-linked genes and associated adjustment of expression of X-linked gametologs (dosage compensation) may lead to rapid evolution of sex-linked species incompatibilities...
May 21, 2018: Molecular Ecology
https://www.readbyqxmd.com/read/29780764/gender-differences-in-the-relationship-between-built-environment-and-non-communicable-diseases-a-systematic-review
#9
Joanna Sara Valson, V Raman Kutty
Non-communicable diseases are on the rise globally. Risk factors of non-communicable diseases continue to be a growing concern in both developed and developing countries. With significant rise in population and establishment of buildings, rapid changes have taken place in the built environment. Relationship between health and place, particularly with non-communicable diseases has been established in previous literature. This systematic review assesses the current evidence on influence of gender in the relationship between built environment and non-communicable diseases...
February 5, 2018: Journal of Public Health Research
https://www.readbyqxmd.com/read/29780744/employing-dimensional-disparity-of-teeth-to-establish-the-gender-in-odisha-population-a-dimorphic-study
#10
Kailash Chandra Dash, Abikshyeet Panda, Shyam Sundar Behura, Sujatha Ramachandra, Lipsa Bhuyan, Alokenath Bandopadhyay
Aims and Objectives: Determination of sex is one of the most important and crucial steps in forensic science. Sexual dimorphism using odontometric analysis is found to vary in different populations making it necessary to attain values of a specific population which helps the identification possible. This present study attempts to establish sexual dimorphism using odontometric analysis in Odisha population. Materials and Methods: A total of 200 subjects (100 male and 100 female) between ages 18 and 25 years were included in the study...
March 2018: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/29780582/the-convergent-epidemiology-of-tuberculosis-and-human-cytomegalovirus-infection
#11
Frank Cobelens, Nico Nagelkerke, Helen Fletcher
Although several factors are known to increase the risk of tuberculosis, the occurrence of tuberculosis disease in an infected individual is difficult to predict. We hypothesize that active human cytomegalovirus infection due to recent infection, reinfection or reactivation plays an epidemiologically relevant role in the aetiology of tuberculosis by precipitating the progression from latent tuberculosis infection to disease. The most compelling support for this hypothesis comes from the striking similarity in age-sex distribution between the two infections, important because the age-sex pattern of tuberculosis disease progression has not been convincingly explained...
2018: F1000Research
https://www.readbyqxmd.com/read/29779929/prescription-medication-use-and-antinuclear-antibodies-in-the-united-states-1999-2004
#12
Gregg E Dinse, Christine G Parks, Helen C S Meier, Caroll A Co, Edward K L Chan, Todd A Jusko, James Yeh, Frederick W Miller
BACKGROUND: Clinical reports link specific medications with the development of antinuclear antibodies (ANA), but population-based evidence is limited. OBJECTIVE: The present study investigated associations between prescription medication use and ANA in a representative sample of the adult noninstitutionalized US population, first focusing on medications previously related to ANA and then considering all medications reported in the National Health and Nutrition Examination Survey (NHANES)...
May 17, 2018: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29779792/predictors-of-weeks-to-opioid-cessation-after-lumbar-fusion-a-prospective-cohort-study
#13
Maureen P Lall, Elizabeth Restrepo
Although the use of prescription opioid analgesics to treat acute, postoperative pain is a well-established practice, the role of opioids in the management of persistent, postoperative pain remains ill-defined. Nevertheless, high rates of long-term opioid use following lumbar fusion have been reported. The goal of this prospective, longitudinal study was to identify predictors of weeks to opioid cessation in a cohort of patients undergoing elective lumbar fusion. Prior to surgery, participants self-reported demographic and clinical data and completed a validated measure of pain catastrophizing...
May 17, 2018: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
https://www.readbyqxmd.com/read/29779203/subjective-social-status-and-mortality-the-english-longitudinal-study-of-ageing
#14
Panayotes Demakakos, Jane P Biddulph, Cesar de Oliveira, Georgios Tsakos, Michael G Marmot
Self-perceptions of own social position are potentially a key aspect of socioeconomic inequalities in health, but their association with mortality remains poorly understood. We examined whether subjective social status (SSS), a measure of the self-perceived element of social position, was associated with mortality and its role in the associations between objective socioeconomic position (SEP) measures and mortality. We used Cox regression to model the associations between SSS, objective SEP measures and mortality in a sample of 9972 people aged ≥ 50 years from the English Longitudinal Study of Ageing over a 10-year follow-up (2002-2013)...
May 19, 2018: European Journal of Epidemiology
https://www.readbyqxmd.com/read/29779029/low-plasma-hydrogen-sulfide-is-associated-with-impaired-renal-function-and-cardiac-dysfunction
#15
Qing Kuang, Ning Xue, Jing Chen, Ziyan Shen, Xiaomeng Cui, Yi Fang, Xiaoqiang Ding
BACKGROUND: Chronic kidney disease (CKD) has been proposed to associate with decreased hydrogen sulfide (H2S) level. Nevertheless, the role of H2S in the pathogenesis of CKD has not been fully investigated. Our study aimed to investigate the plasma level of endogenous H2S in patients with different stages of CKD, and to identify the role of H2S in the progression of CKD and its relationship with cardiovascular diseases. METHODS: A total of 157 non-dialysis CKD patients were recruited in our study, with 37 age- and sex-matched healthy individuals as control...
May 18, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29778641/subregional-volumes-of-the-hippocampus-in-relation-to-cognitive-function-and-risk-of-dementia
#16
Tavia E Evans, Hieab H H Adams, Silvan Licher, Frank J Wolters, Aad van der Lugt, M Kamran Ikram, Michael J O'Sullivan, Meike W Vernooij, M Arfan Ikram
BACKGROUND: Total hippocampal volume has been consistently linked to cognitive function and dementia. Yet, given its complex and parcellated internal structure, the role of subregions of the hippocampus in cognition and risk of dementia remains relatively underexplored. We studied subregions of the hippocampus in a large population-based cohort to further understand their role in cognitive impairment and dementia risk. METHODS: We studied 5035 dementia- and stroke-free persons from the Rotterdam Study, aged over 45 years...
May 17, 2018: NeuroImage
https://www.readbyqxmd.com/read/29778539/expressional-and-functional-comparisons-of-two-general-odorant-binding-proteins-in-agrotis-ipsilon
#17
Guang-Zhen Huang, Jing-Tao Liu, Jing-Jiang Zhou, Qian Wang, Jian-Zhen Dong, Yong-Jun Zhang, Xian-Chun Li, Jing Li, Shao-Hua Gu
Insect general odorant binding proteins (GOBPs) have been long thought to bind and transport host plant volatiles to the olfactory receptors on the dendrite membrane of the olfactory neurons. Recent studies indicate that they can also bind female sex pheromones. In present study, two GOBP genes, AipsGOBP1 and AipsGOBP2 were cloned from the adult antennae of Agrotis ipsilon. Tissue expression profiles indicated that both of them are antennae-specific and more abundant in the female antennae than in the male antennae...
May 17, 2018: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29777819/7-tesla-magnetic-resonance-imaging-of-caudal-anterior-cingulate-and-posterior-cingulate-cortex-atrophy-in-patients-with-trigeminal-neuralgia
#18
Hyeong Cheol Moon, Chan-A Park, Yeong-Jae Jeon, Soon Tae You, Hyun Man Baek, Youn Joo Lee, Chul Beom Cho, Chae Joon Cheong, Young Seok Park
The cingulate cortex (CC) is a brain region that plays a key role in pain processing, but CC abnormalities are not unclear in patients with trigeminal neuralgia (TN). The purpose of this study was to determine the central causal mechanisms of TN and the surrounding brain structure in healthy controls and patients with TN using 7 Tesla (T) magnetic resonance imaging (MRI). Whole-brain parcellation in gray matter volume and thickness was assessed in 15 patients with TN and 16 healthy controls matched for sex, age, and regional variability using T1-weighted imaging...
May 16, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29777688/proteomic-changes-during-adult-stage-in-pre-optic-hypothalamus-hippocampus-and-pituitary-regions-of-female-rat-brain-following-neonatal-exposure-to-estradiol-17%C3%AE
#19
Vijayakumar Govindaraj, Radhika Nagamangalam Shridharan, Addicam Jagannadha Rao
Although neonatal exposure to estrogen or estrogenic compounds results in irreversible changes in the brain function and reproductive abnormalities during adulthood but the underlying mechanisms are still largely unknown. The present study has attempted to compare the protein profiles of sexually dimorphic brain regions of adult female rats which were exposed to estradiol- 17β during neonatal period. The total proteins extracted from pre-optic area (POA), hypothalamus, hippocampus and pituitary of control and neonatally E2 treated female rats was subjected to 2D-SDS-PAGE and differentially expressed proteins were identification by MALDI TOF/TOF-MS...
May 16, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29777472/circumscribed-interests-and-attention-in-autism-the-role-of-biological-sex
#20
Clare Harrop, Desiree Jones, Shuting Zheng, Sallie Nowell, Brian A Boyd, Noah Sasson
Recent studies suggest that circumscribed interests (CI) in females with Autism Spectrum Disorder (ASD) may align more closely with interests reported in typical female development than those typically reported for ASD males. We used eye-tracking to quantify attention to arrays containing combinations of male, female and neutral images in elementary-aged males and females with and without ASD. A number of condition × sex effects emerged, with both groups attending to images that corresponded with interests typically associated with their biological sex...
May 18, 2018: Journal of Autism and Developmental Disorders
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