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frontal selection positivity

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https://www.readbyqxmd.com/read/29053832/reward-deficits-in-behavioural-variant-frontotemporal-dementia-include-insensitivity-to-negative-stimuli
#1
David C Perry, Samir Datta, Virginia E Sturm, Kristie A Wood, Jessica Zakrzewski, William W Seeley, Bruce L Miller, Joel H Kramer, Howard J Rosen
During reward processing individuals weigh positive and negative features of a stimulus to determine whether they will pursue or avoid it. Though patients with behavioural variant frontotemporal dementia display changes in their pursuit of rewards, such as food, alcohol, money, and sex, the basis for these shifts is not clearly established. In particular, it is unknown whether patients' behaviour results from excessive focus on rewards, insensitivity to punishment, or to dysfunction in a particular stage of reward processing, such as anticipation, consumption, or action selection...
October 7, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29045559/segregated-excitatory-inhibitory-recurrent-subnetworks-in-layer-5-of-the-rat-frontal-cortex
#2
Mieko Morishima, Kenta Kobayashi, Shigeki Kato, Kazuto Kobayashi, Yasuo Kawaguchi
A prominent feature of neocortical pyramidal cells (PCs) is their numerous projections to diverse brain areas. In layer 5 (L5) of the rat frontal cortex, there are 2 major subtypes of PCs that differ in their long-range axonal projections, corticopontine (CPn) cells and crossed corticostriatal (CCS) cells. The outputs of these L5 PCs can be regulated by feedback inhibition from neighboring cortical GABAergic cells. Two major subtypes of GABAergic cells are parvalbumin (PV)-positive and somatostatin (SOM)-positive cells...
October 17, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29038082/supraorbital-approach-for-resection-of-clinoidal-meningioma
#3
Rimal H Dossani, Piyush Kalakoti, Bharat Guthikonda
Meningiomas of the clinoid region pose formidable surgical challenge. Pterional craniotomy is the traditional approach, and often associated with high-risk post-surgical morbidities. In the current presentation, we describe an elderly male with a clinoidal meningioma that underwent a minimally invasive supra-orbital craniotomy for tumor resection. Patient presentation, neuroimaging, and surgical techniques (patient position, incision, anatomical consideration, and surgical steps) are described meticulously...
October 13, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29018368/biclustered-independent-component-analysis-for-complex-biomarker-and-subtype-identification-from-structural-magnetic-resonance-images-in-schizophrenia
#4
Cota Navin Gupta, Eduardo Castro, Srinivas Rachkonda, Theo G M van Erp, Steven Potkin, Judith M Ford, Daniel Mathalon, Hyo Jong Lee, Bryon A Mueller, Douglas N Greve, Ole A Andreassen, Ingrid Agartz, Andrew R Mayer, Julia Stephen, Rex E Jung, Juan Bustillo, Vince D Calhoun, Jessica A Turner
Clinical and cognitive symptoms domain-based subtyping in schizophrenia (Sz) has been critiqued due to the lack of neurobiological correlates and heterogeneity in symptom scores. We, therefore, present a novel data-driven framework using biclustered independent component analysis to detect subtypes from the reliable and stable gray matter concentration (GMC) of patients with Sz. The developed methodology consists of the following steps: source-based morphometry (SBM) decomposition, selection and sorting of two component loadings, subtype component reconstruction using group information-guided ICA (GIG-ICA)...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28955208/nicotinic-acetylcholine-receptor-%C3%AE-9-and-%C3%AE-10-subunits-are-expressed-in-the-brain-of-mice
#5
Olena Lykhmus, Larysa P Voytenko, Katrin S Lips, Ivonne Bergen, Gabriela Krasteva-Christ, Douglas E Vetter, Wolfgang Kummer, Maryna Skok
The α9 and α10 nicotinic acetylcholine receptor (nAChR) subunits are likely to be the evolutionary precursors to the entire cys-loop superfamily of ligand-gated ion channels, which includes acetylcholine, GABA, glycine and serotonin ionotropic receptors. nAChRs containing α9 and α10 subunits are found in the inner ear, dorsal root ganglia and many non-excitable tissues, but their expression in the central nervous system has not been definitely demonstrated. Here we show the presence of both α9 and α10 nAChR subunits in the mouse brain by RT-PCR and immunochemical approaches with a range of nAChR subunit-selective antibodies, which selectivity was demonstrated in the brain preparations of α7-/-, α9-/- and α10-/- mice...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28942367/laughter-catches-attention
#6
Ana P Pinheiro, Carla Barros, Marcelo Dias, Sonja A Kotz
In social interactions, emotionally salient and sudden changes in vocal expressions attract attention. However, only a few studies examined how emotion and attention interact in voice processing. We investigated neutral, happy (laughs) and angry (growls) vocalizations in a modified oddball task. Participants silently counted the targets in each block and rated the valence and arousal of the vocalizations. A combined event-related potential and time-frequency analysis focused on the P3 and pre-stimulus alpha power to capture attention effects in response to unexpected events...
September 21, 2017: Biological Psychology
https://www.readbyqxmd.com/read/28920103/existence-of-brain-5-ht1a-5-ht2a-isoreceptor-complexes-with-antagonistic-allosteric-receptor-receptor-interactions-regulating-5-ht1a-receptor-recognition
#7
Dasiel O Borroto-Escuela, Xiang Li, Alexander O Tarakanov, David Savelli, Manuel Narváez, Kirill Shumilov, Yuniesky Andrade-Talavera, Antonio Jimenez-Beristain, Bartosz Pomierny, Zaida Díaz-Cabiale, Riccardo Cuppini, Patrizia Ambrogini, Maria Lindskog, Kjell Fuxe
Studies on serotonin-selective reuptake inhibitors have established that disturbances in the ascending 5-HT neuron systems and their 5-HT receptor subtypes and collateral networks to the forebrain contribute to the etiology of major depression and are targets for treatment. The therapeutic action of serotonin-selective reuptake inhibitors is of proven effectiveness, but the mechanisms underlying their effect are still unclear. There are many 5-HT subtypes involved; some need to be blocked (e.g., 5-HT2A, 5-HT3, and 5-HT7), whereas others need to be activated (e...
August 31, 2017: ACS Omega
https://www.readbyqxmd.com/read/28879544/brain-cortical-characteristics-of-lifetime-cognitive-ageing
#8
Simon R Cox, Mark E Bastin, Stuart J Ritchie, David Alexander Dickie, Dave C Liewald, Susana Muñoz Maniega, Paul Redmond, Natalie A Royle, Alison Pattie, Maria Valdés Hernández, Janie Corley, Benjamin S Aribisala, Andrew M McIntosh, Joanna M Wardlaw, Ian J Deary
Regional cortical brain volume is the product of surface area and thickness. These measures exhibit partially distinct trajectories of change across the brain's cortex in older age, but it is unclear which cortical characteristics at which loci are sensitive to cognitive ageing differences. We examine associations between change in intelligence from age 11 to 73 years and regional cortical volume, surface area, and thickness measured at age 73 years in 568 community-dwelling older adults, all born in 1936...
September 6, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28871717/acromegaly-determination-using-discriminant-analysis-of-the-three-dimensional-facial-classification-in-taiwanese
#9
Ming-Hsu Wang, Jen-Der Lin, Chen-Nen Chang, Wen-Ko Chiou
OBJECTIVES: The aim of this study was to assess the size, angles and positional characteristics of facial anthropometry between "acromegalic" patients and control subjects. We also identify possible facial soft tissue measurements for generating discriminant functions toward acromegaly determination in males and females for acromegaly early self-awareness. MATERIAL AND METHODS: This is a cross-sectional study. Subjects participating in this study included 70 patients diagnosed with acromegaly (35 females and 35 males) and 140 gender-matched control individuals...
August 5, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28871034/domain-general-brain-regions-do-not-track-linguistic-input-as-closely-as-language-selective-regions
#10
Idan Blank, Evelina Fedorenko
Language comprehension engages a cortical network of left frontal and temporal regions. Activity in this network is language-selective, showing virtually no modulation by non-linguistic tasks. In addition, language comprehension engages a second network consisting of bilateral frontal, parietal, cingulate, and insular regions. Activity in this "Multiple Demand (MD)" network scales with comprehension difficulty, but also with cognitive effort across a wide range of non-linguistic tasks in a domain-general fashion...
September 4, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28836300/cerebral-amyloid-angiopathy-initially-occurs-in-the-meningeal-vessels
#11
Shigeki Takeda, Kazunori Yamazaki, Teruo Miyakawa, Kiyoshi Onda
To clarify the frequency of CAA in the brain parenchyma and subarachnoid space (SAS), we counted sections of blood vessels showing positive staining for Aβ in the SAS, cerebral cortex (CC) and cerebral white matter (WM) using paraffin-embedded sections of the frontal, temporal and occipital lobes. The specimens had been taken for routine neuropathological examination from the brains of 105 Japanese patients (aged 40-95 years) selected from among 200 consecutive patients autopsied between 1989 and 2015 at our hospital...
August 23, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28822943/sound-side-joint-contact-forces-in-below-knee-amputee-gait-with-an-esar-prosthetic-foot
#12
Mohammad Taghi Karimi, Firooz Salami, Amir Esrafilian, Daniel W W Heitzmann, Merkur Alimusaj, Cornelia Putz, Sebastian I Wolf
The incidence of knee and hip joint osteoarthritis in subjects with below knee amputation (BK) appears significantly higher compared to unimpaired subjects, especially in the intact side. However, it is controversial if constant higher loads on the sound side are one of the major factors for an increased osteoarthritis (OA) incidence in subjects with BK, beside other risk factors, e.g. with respect to metabolism. The aim wasto investigate joint contact forces (JCF) calculated by a musculoskeletal model in the intact side and to compare it with those of unimpaired subjects and to further elucidate in how far increased knee JCF are associated with increased frontal plane knee moments...
October 2017: Gait & Posture
https://www.readbyqxmd.com/read/28776708/the-effect-of-category-learning-on-visual-attention-and-visual-representation
#13
Jonathan R Folstein, Shamsi S Monfared, Trevor Maravel
Subordinate-level category learning recruits neural resources associated with perceptual expertise, including the N250 component of the ERP, a posterolateral negative wave maximal between 230 and 330 ms. The N250 is a relatively late visual ERP and could plausibly be driven by attention to the features of categorized objects. Indeed, it has a latency and scalp distribution similar to the selection negativity (SN), an ERP component long known to be sensitive to attentional selection of target features. To clarify sensitivity of the N250 to attention and to more generally investigate the effect of category learning on attentional modulation of learned features, we independently manipulated subordinate-level category learning and target detection in a speeded paradigm designed to optimally elicit the SN and accompanying frontal selection positivity (FSP)...
August 4, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28746244/the-effect-of-unicycle-riding-course-on-trunk-strength-and-trunk-stability-functions-in-children
#14
Andrej Kocjan, Nejc Sarabon
PURPOSE: The aim of the study was to assess the effect of unicycling on trunk strength and timing of automatic stability actions of the selected trunk muscles (multifidus, obliquus externus, erector spine). METHODS: Twenty healthy 12-year-old children (12 boys, 8 girls; age 12.1 ± 0.2 yrs; body height 1.57 ± 0.05 m; body mass 52.8 ± 10.6 kg) were assigned to experimental and control group. Experimental group performed a supervised 12-session course of unicycling...
July 24, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28741037/shifted-dynamic-interactions-between-subcortical-nuclei-and-inferior-frontal-gyri-during-response-preparation-in-persistent-developmental-stuttering
#15
F Luise Metzger, Tibor Auer, Gunther Helms, Walter Paulus, Jens Frahm, Martin Sommer, Nicole E Neef
Persistent developmental stuttering is associated with basal ganglia dysfunction or dopamine dysregulation. Here, we studied whole-brain functional connectivity to test how basal ganglia structures coordinate and reorganize sensorimotor brain networks in stuttering. To this end, adults who stutter and fluent speakers (control participants) performed a response anticipation paradigm in the MRI scanner. The preparation of a manual Go/No-Go response reliably produced activity in the basal ganglia and thalamus and particularly in the substantia nigra...
July 24, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28740088/functional-correlates-of-tsh-ft3-and-ft4-in-alzheimer-disease-a-f-18-fdg-pet-ct-study
#16
Agostino Chiaravalloti, Francesco Ursini, Alessandro Fiorentini, Gaetano Barbagallo, Alessandro Martorana, Giacomo Koch, Mario Tavolozza, Orazio Schillaci
The present study was aimed to investigate the relationships between thyroid stimulating hormone (TSH), freeT3 (fT3) and freeT4 (fT4) and brain glucose consumption as detectable by means of 2-deoxy-2-(F-18) fluoro-D-glucose (F-18 FDG) Positron Emission Tomography/Computed Tomography (PET/CT) in a selected population with Alzheimer disease (AD). We evaluated 87 subjects (37 males and 50 females, mean age 70 (±6) years old) with AD. All of them were subjected to TSH, fT3 and fT4 assay and to cerebrospinal fluid amyloid (Aβ1-42) and tau [phosphorylated-tau (p-tau) and total-tau (t-tau)] assay prior PET/CT examination...
July 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28727235/thermal-imaging-and-dermoscopy-for-detecting-inflammation-in-frontal-fibrosing-alopecia
#17
Anna Lis-Święty, Bartosz Miziołek, Irmina Ranosz-Janicka, Grażyna Bierzyńska-Macyszyn, Ligia Brzezińska-Wcisło
BACKGROUND: Frontal fibrosing alopecia (FFA) is an inflammatory condition of the scalp, which leads to scarring and slowly progressive recession of frontotemporal and/or frontoparietal hairline. Choice of FFA treatment is highly dependent on accurate assessment of disease phase, as medical treatments are effective only during the initial inflammatory stage. METHODS: To objectively quantify the activity of the inflammatory process in FFA, 22 female patients were examined by both infrared thermography and optical dermoscopy before tissue sampling...
July 20, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28725962/optimal-positioning-of-the-nipple-areola-complex-in-men-using-the-mohrenheim-estimated-tangential-tracking-line-mett-line-an-intuitive-approach
#18
Tobias R Mett, Nicco Krezdorn, Rosalia Luketina, Maria K Boyce, Helga Henseler, Ramin Ipaktchi, Peter M Vogt
INTRODUCTION: The reconstruction of the body shape after post-bariatric surgery or high-grade gynecomastia involves, besides skin tightening, the repositioning of anatomical, apparent landmarks. The surgeon usually defines these during the preoperative planning. In particular, the positions of the nipple-areola complexes (NAC) should contribute to the gender-appropriate appearance. While in the female breast numerous methods have been developed to determine the optimal position of the NACs, there are only a few, metric and often impractical algorithms for positioning the nipples and areoles in the male...
July 19, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28713312/neural-temporal-dynamics-of-facial-emotion-processing-age-effects-and-relationship-to-cognitive-function
#19
Xiaoyan Liao, Kui Wang, Kai Lin, Raymond C K Chan, Xiaoyuan Zhang
This study used event-related potentials (ERPs) to investigate the effects of age on neural temporal dynamics of processing task-relevant facial expressions and their relationship to cognitive functions. Negative (sad, afraid, angry, and disgusted), positive (happy), and neutral faces were presented to 30 older and 31 young participants who performed a facial emotion categorization task. Behavioral and ERP indices of facial emotion processing were analyzed. An enhanced N170 for negative faces, in addition to intact right-hemispheric N170 for positive faces, was observed in older adults relative to their younger counterparts...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28689051/projection-targets-of-medial-frontal-d1dr-expressing-neurons
#20
Sang-Woo Han, Young-Cho Kim, Nandakumar S Narayanan
Prefrontal neurons expressing D1-type dopamine receptors (D1DRs) have been implicated in a variety of cognitive processes including working memory and timing. Although D1DRs are most strongly expressed on layer V/VI projection neurons, it is unknown which brain areas are specifically targeted by these projections. Here we selectively marked D1DR neurons using cre-loxP techniques with AAV carrying mCherry fluorescent protein, and traced projection targets of D1DR+ neurons in the mouse medial frontal cortex (MFC)...
August 10, 2017: Neuroscience Letters
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