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https://www.readbyqxmd.com/read/28220552/activation-of-the-mtor-dependent-signaling-pathway-underlies-ketamine-induced-uropathy
#1
Chih-Chieh Lin, An-Hang Yang, Alex Tong-Long Lin
AIMS: To investigate the pathogenic role of activation of the mammalian target of the rapamycin (mTOR) in the ketamine induced microvascular injury. METHODS: Twenty-three patients with ketamine-induced cystitis (KC) and 16 control volunteers were recruited. Bladder tissues were obtained from both groups by cystoscopic biopsies. Phospho-S6 ribosomal protein (p-S6RP), an end product of the mTOR pathway, was stained in the urinary bladder from both groups. Endothelial cells of the urinary bladder (HBdMECs) were examined to investigate the in vitro activation of the mTOR pathway and the co-expression of the endothelial marker (cluster of differentiation 31 [CD31]) and the mesenchymal marker (fibroblast-specific protein 1 [FSP-1])...
February 21, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28206897/retrospective-study-of-the-survival-rates-of-indirect-pulp-therapy-versus-different-pulpotomy-medicaments
#2
Patrice Barsamian Wunsch, Marissa M Kuhnen, Al M Best, Tegwyn H Brickhouse
PURPOSE: The purposes of this retrospective chart review were to determine: (1) how primary molars in need of vital pulp therapy (VPT) have been treated over a period of four years at a university-based pediatric dental practice (UBP); and which treatments-indirect pulp therapy (IPT), formocresol pulpotomy (FCP), and ferric sulfate pulpotomy (FSP)-have been successful. METHODS: Electronic patient records (axiUm) that contained the procedure codes D3120 (pulp cap-indirect) or D3220 (therapeutic pulpotomy) were totaled by year...
October 15, 2016: Pediatric Dentistry
https://www.readbyqxmd.com/read/28187522/survey-of-patient-and-partner-satisfaction-following-collagenase-clostridium-histolyticum-treatment-for-peyronie-s-disease
#3
J Anaissie, F A Yafi, E J Traore, S C Sikka, W J G Hellstrom
Intralesional injection of collagenase Clostridium histolyticum (CCH) is a minimally invasive, Food and Drug Administration-approved, effective treatment for Peyronie's disease (PD). To assess the satisfaction of patients and their female sexual partners (FSP) following CCH therapy for PD, we conducted a retrospective review of the records of all patients treated with CCH for PD between 04/2014 and 03/2016. Collected variables included demographics, pre- and post-treatment sexual function, penile curvature, penile vascular findings, and treatment outcomes...
February 10, 2017: Andrology
https://www.readbyqxmd.com/read/28146484/high-spatial-resolution-phase-sensitive-optical-time-domain-reflectometer-with-a-frequency-swept-pulse
#4
Bin Lu, Zhengqing Pan, Zhaoyong Wang, Hanrong Zheng, Qing Ye, Ronghui Qu, Haiwen Cai
A high spatial resolution phase-sensitive optical time domain reflectometer (ϕ-OTDR) with an optical frequency-swept pulse (FSP) is proposed, and the experimental results are presented in the Letter. The FSP ϕ-OTDR uses optical pulses with linear frequency modulation with higher pulse energy for longer sensing fiber and uses matched filter in the receiver to compress the processed pulse width. Thus, the contradiction between spatial resolution and the working distance in ordinary ϕ-OTDR is relaxed. A spatial resolution of 30 cm, a sensing distance of 19...
February 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28142386/system-transformation-under-the-california-mental-health-services-act-implementation-of-full-service-partnerships-in-l-a-county
#5
Sarah L Starks, Paul G Arns, Howard Padwa, Jack R Friedman, Jocelyn Marrow, Marcia L Meldrum, Elizabeth Bromley, Erin L Kelly, John S Brekke, Joel T Braslow
OBJECTIVE: The study evaluated the effect of California's Mental Health Services Act (MHSA) on the structure, volume, location, and patient centeredness of Los Angeles County public mental health services. METHODS: This prospective mixed-methods study (2006-2013) was based in five Los Angeles County public mental health clinics, all with usual care and three with full-service partnerships (FSPs). FSPs are MHSA-funded programs designed to "do whatever it takes" to provide intensive, recovery-oriented, team-based, integrated services for clients with severe mental illness...
February 1, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28088081/lead-pb-2-and-copper-cu-2-remediation-from-water-using-superparamagnetic-maghemite-%C3%AE-fe2o3-nanoparticles-synthesized-by-flame-spray-pyrolysis-fsp
#6
Shalini Rajput, Lok P Singh, Charles U Pittman, Dinesh Mohan
Superparamagnetic maghemite (γ-Fe2O3) nanoparticles of controllable morphology were successfully synthesized using a flame spray pyrolysis (FSP) technique. Their physico-chemical properties, size, morphology, and surface chemistries were determined using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), selected area electron diffraction patterns (SAED), SEM-EDX, scanning electron microscopy (SEM), and pHZPC(6.3). Elemental contents before and after adsorption were identified using energy dispersive X-ray fluorescence (ED-XRF), energy dispersive X-ray analysis (EDX) and elemental mapping...
April 15, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28068213/utilization-of-size-polymorphism-in-its1-and-its2-regions-for-identification-of-pathogenic-yeast-species
#7
Hossein Khodadadi, Ladan Karimi, Niloufar Jalali-Zand, Hassan Adin, Hossein Mirhendi
Despite the existence of a variety of available yeast identification strategies, easier and more cost-effective methods are required for routine use in clinical laboratories. The internal transcribed spacer (ITS) regions of fungal rRNA genes exhibit variable sizes depending on the yeast species. In the present study, fragment size polymorphism (FSP) analysis of the ITS1 and ITS2 regions for identification of the clinically most important yeast species was assessed. The ITS1 and ITS2 regions of 190 strains, including isolates of 31 standard strains and 159 clinical isolates, were separately PCR-amplified with two primer sets: ITS1-ITS2 and ITS3-ITS4...
January 9, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28026936/safe-by-design-cuo-nanoparticles-via-fe-doping-cu-o-bond-length-variation-and-biological-assessment-in-cells-and-zebrafish-embryos
#8
Hendrik Naatz, Sijie Lin, Ruibin Li, Wen Jiang, Zhaoxia Ji, Chong Hyun Chang, Jan Köser, Jorg Thöming, Tian Xia, Andre E Nel, Lutz Mädler, Suman Pokhrel
The safe implementation of nanotechnology requires nanomaterial hazard assessment in accordance with the material physicochemical properties that trigger the injury response at the nano/bio interface. Since CuO nanoparticles (NPs) are widely used industrially and their dissolution properties play a major role in hazard potential, we hypothesized that tighter bonding of Cu to Fe by particle doping could constitute a safer-by-design approach through decreased dissolution. Accordingly, we designed a combinatorial library in which CuO was doped with 1-10% Fe in a flame spray pyrolysis reactor...
January 3, 2017: ACS Nano
https://www.readbyqxmd.com/read/27976814/neural-mechanisms-of-attention-become-more-specialised-during-infancy-insights-from-combined-eye-tracking-and-eeg
#9
Louisa Kulke, Janette Atkinson, Oliver Braddick
: The Fixation Shift Paradigm (FSP) measures infants' ability to shift gaze from a central fixation stimulus to a peripheral target (e.g. Hood & Atkinson, 1993: Infant Behavior and Development, 16(4), 405-422). Cortical maturation has been suggested as crucial for the developing ability to shift attention. This study investigated the development of neural mechanisms by combining EEG with simultaneous eye tracking during FSP testing, in typically developing infants aged between 1 and 8 months...
December 15, 2016: Developmental Psychobiology
https://www.readbyqxmd.com/read/27958394/proliferation-and-osteogenic-differentiation-of-rat-bmscs-on-a-novel-ti-sic-metal-matrix-nanocomposite-modified-by-friction-stir-processing
#10
Chenyuan Zhu, Yuting Lv, Chao Qian, Haixin Qian, Ting Jiao, Liqiang Wang, Fuqiang Zhang
The aims of this study were to fabricate a novel titanium/silicon carbide (Ti/SiC) metal matrix nanocomposite (MMNC) by friction stir processing (FSP) and to investigate its microstructure and mechanical properties. In addition, the adhesion, proliferation and osteogenic differentiation of rat bone marrow stromal cells (BMSCs) on the nanocomposite surface were investigated. The MMNC microstructure was observed by both scanning and transmission electron microscopy. Mechanical properties were characterized by nanoindentation and Vickers hardness testing...
December 13, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27916094/-knockdown-of-runx3-inhibits-hypoxia-induced-endothelial-to-mesenchymal-transition-of-human-cardiac-microvascular-endothelial-cells
#11
Yanhua Liu, Bingong Li, Yuqin Wang, Delong Wang, Jin Zou, Xuan Ke, Yanqin Hao
Objective To investigate the effects of Runt-related transcription factor 3 (RUNX3) knockdown on hypoxia-induced endothelial-to-mesenchymal transition (EndoMT) of human cardiac microvascular endothelial cells (HCMECs), and elucidate the underlying molecular mechanism. Methods HCMECs were cultured in hypoxic conditions and infected with RUNX3-RNAi lentivirus to knock-down the expression of RUNX3. Reverse transcription PCR was performed to detect the mRNA expressions of RUNX3 and EndoMT related genes such as CD31, vascular endothelial cadherin (VE-cadherin), α-smooth muscle actin (α-SMA) and fibroblast-specific protein-1 (FSP-1); Western blotting was used to determine the protein expressions of RUNX3, CD31, α-SMA and another molecules involved in EndoMT; and immunofluorescence cytochemistry was applied to observe the colocalization of CD31 and α-SMA...
December 2016: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/27909303/conditional-knockout-of-n-wasp-in-mouse-fibroblast-caused-keratinocyte-hyper-proliferation-and-enhanced-wound-closure
#12
Neeraj Jain, Pazhanichamy Kalailingam, Kai Wei Tan, Hui Bing Tan, Ming Keat Sng, Jeremy Soon Kiat Chan, Nguan Soon Tan, Thirumaran Thanabalu
Neural-Wiskott Aldrich Syndrome Protein (N-WASP) is expressed ubiquitously, regulates actin polymerization and is essential during mouse development. We have previously shown that N-WASP is critical for cell-ECM adhesion in fibroblasts. To characterize the role of N-WASP in fibroblast for skin development, we generated a conditional knockout mouse model in which fibroblast N-WASP was ablated using the Cre recombinase driven by Fibroblast Specific Protein promoter (Fsp-Cre). N-WASP(FKO) (N-WASP(fl/fl); Fsp-cre) were born following Mendelian genetics, survived without any visible abnormalities for more than 1 year and were sexually reproductive, suggesting that expression of N-WASP in fibroblast is not critical for survival under laboratory conditions...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27907099/analysis-of-a-mouse-skin-model-of-tuberous-sclerosis-complex
#13
Yanan Guo, John R Dreier, Juxiang Cao, Heng Du, Scott R Granter, David J Kwiatkowski
Tuberous Sclerosis Complex (TSC) is an autosomal dominant tumor suppressor gene syndrome in which patients develop several types of tumors, including facial angiofibroma, subungual fibroma, Shagreen patch, angiomyolipomas, and lymphangioleiomyomatosis. It is due to inactivating mutations in TSC1 or TSC2. We sought to generate a mouse model of one or more of these tumor types by targeting deletion of the Tsc1 gene to fibroblasts using the Fsp-Cre allele. Mutant, Tsc1ccFsp-Cre+ mice survived a median of nearly a year, and developed tumors in multiple sites but did not develop angiomyolipoma or lymphangioleiomyomatosis...
2016: PloS One
https://www.readbyqxmd.com/read/27901488/cancer-associated-fibroblasts-promote-cancer-cell-growth-through-a-mir-7-rassf2-par-4-axis-in-the-tumor-microenvironment
#14
Zongze Shen, Xing Qin, Ming Yan, Rongrong Li, Gang Chen, Jianjun Zhang, Wantao Chen
Cancer-associated fibroblasts (CAFs), a major component of cancer stroma, play an important role in cancer progression but little is known about how CAFs affect tumorigenesis and development. MicroRNAs (miRNAs) are small non-coding RNAs that can negatively regulate target mRNA expression at post-transcriptional levels. In head and neck cancer (HNC), our analysis of miRNA arrays showed that miR-7, miR-196 and miR-335 were significantly up-regulated in CAFs when compared with their paired normal fibroblasts (NFs)...
January 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/27893738/fenugreek-seed-powder-nullified-aluminium-chloride-induced-memory-loss-biochemical-changes-a%C3%AE-burden-and-apoptosis-via-regulating-akt-gsk3%C3%AE-signaling-pathway
#15
Asokan Prema, Arokiasamy Justin Thenmozhi, Thamilarasan Manivasagam, Musthafa Mohamed Essa, Mohammed D Akbar, Mohammed Akbar
Alzheimer's disease (AD) is the most common form of dementia that mainly affects the cognitive functions of the aged populations. Trigonella foenum-graecum (L.) (fenugreek), a traditionally well utilized medicinal plant ubiquitously used as one of the main food additive worldwide, is known to have numerous beneficial health effects. Fenugreek seed extract could be able to inhibit the activity of acetylcholinesterase (AChE), a key enzyme involved in the pathogenesis of AD, and further shown to have anti-parkinsonic effect...
2016: PloS One
https://www.readbyqxmd.com/read/27885713/a-new-tool-to-quantify-the-geometrical-characteristics-of-facial-skin-pores-changes-with-age-and-a-making-up-procedure-in-caucasian-women
#16
A Shaiek, F Flament, G François, V Lefebvre-Descamps, C Barla, M Vicic, F Giron, R Bazin
BACKGROUND: Facial skin pores (FSP) are common and benign signs that generate frequent esthetic concerns or complaints. Despite their worldwide prevalence, related literature remains scarce. Hence, a new device has been developed and applied to validating studies, aiming at best describing FSP as they are self-perceived, i.e. their anatomic features, their possible alterations with age and their appearance after application of a make-up product. METHODS: Dermascore+(®) is an imaging device dedicated to a direct observation and acquisition of various characteristics of the skin surface...
November 25, 2016: Skin Research and Technology
https://www.readbyqxmd.com/read/27816514/discovery-of-novel-pyrrolidineoxy-substituted-heteroaromatics-as-potent-and-selective-pi3k-delta-inhibitors-with-improved-physicochemical-properties
#17
Klemens Hoegenauer, Nicolas Soldermann, Christina Hebach, Gregory J Hollingworth, Ian Lewis, Anette von Matt, Alexander B Smith, Romain M Wolf, Rainer Wilcken, Dorothea Haasen, Christoph Burkhart, Frédéric Zécri
In the recent years, PI3Kδ has emerged as a promising target for the treatment of B- and T-cell mediated inflammatory diseases. We present a cellular assay activity analysis for our previously reported 4,6-diaryl quinazoline PI3Kδ inhibitor series that suggests an optimal logP range between 2 and 3. We discovered novel analogues in this lipophilicity space that feature a chiral pyrrolidineoxy-group as a replacement for the position-4 aromatic ring of 4,6-diaryl quinazolines. These Fsp(3) enriched derivatives retain potency and selectivity towards PI3Kδ...
October 27, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27754222/os-32-07-levorotatory-amlodipine-plus-fluvastatin-confer-additive-effects-on-retarding-endothelium-mesenchymal-transition-through-suppressing-rock1-expression
#18
Anping Cai, Yingqing Feng, Yingling Zhou, Jiyan Chen
OBJECTIVE: To investigate the effects and mechanisms of levorotatory (L)-amlodipine combined fluvastatin treatment on endothelium-mesenchymal transition (EndMT), a process related to hypertension development. DESIGN AND METHOD: Human umbilical vein endothelial cells (HUVECs) were used and divided to six groups based on different therapeutic strategies as follows: Blank Control, angiotensin-II (Ang-II), Ang-II+ rho-associated kinase (ROCK) inhibitor, Ang-II+ L-amlodipine, Ang-II+ fluvastatin, and Ang-II +L-amlodipine + fluvastatin groups...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27750737/comparison-of-two-cochlear-implant-coding-strategies-on-speech-perception
#19
Margaret T Dillon, Emily Buss, English R King, Ellen J Deres, Sarah N Obarowski, Meredith L Anderson, Marcia C Adunka
OBJECTIVE: Assess whether differences in speech perception are observed after exclusive listening experience with high-definition continuous interleaved sampling (HDCIS) versus fine structure processing (FSP) coding strategies. METHODS: Subjects were randomly assigned at initial activation of the external speech processor to receive the HDCIS or FSP coding strategy. Frequency filter assignments were consistent across subjects. The speech perception test battery included CNC words in quiet, HINT sentences in quiet and steady noise (+10 dB SNR), AzBio sentences in quiet and a 10-talker babble (+10 dB SNR), and BKB-SIN...
November 2016: Cochlear Implants International
https://www.readbyqxmd.com/read/27750010/solubility-characteristics-of-pcbm-and-c60
#20
David Boucher, Jason Howell
Empirical data indicate that several good solvents for C60 and [6,6]-phenyl-C61-butyric acid methyl ester (PCBM) have substantial polar and hydrogen-bonding components, which are not intrinsic to the structure of the C60 and PCBM molecules themselves. Functional solubility parameter (FSP) and convex solubility parameter (CSP) computations are performed on C60 and PCBM using solubility data available in the literature. The CSP and FSP results are compared to previously reported Hansen solubility parameters (HSPs) and to the parameters calculated using additive functional group contribution methods...
November 10, 2016: Journal of Physical Chemistry. B
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