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https://www.readbyqxmd.com/read/28927611/assessing-the-reactivity-of-cellulose-by-oxidation-with-4-acetamido-2-2-6-6-tetramethylpiperidine-1-oxo-piperidinium-cation-under-mild-conditions
#1
Pegah Khanjani, Saija Väisänen, Ville Lovikka, Kaarlo Nieminen, Thad Maloney, Tapani Vuorinen
The accessibility and reactivity of cellulose are key parameters in its conversion into various products. Several indirect measures, such as water retention value (WRV), fiber saturation point (FSP) and specific surface area (SSA), are often used to characterize cellulosic samples for their reactivity. In this paper, we report on using oxidation with 4-acetamido-2,2,6,6-tetramethylpiperidine-1-oxo-piperidinium cation (4-AcNH-TEMPO(+)) as a probe reaction for the reactivity of cellulose in mild conditions (pH 9, room temperature)...
November 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28917588/association-between-fsp-cvhi-inflammatory-cytokines-and-the-incidence-of-primary-stroke
#2
Xiao-Yun Huang, Wen-Jin Fu, Zhi-Chang Chen, Zhi-Zhong Mei, Ying-Li Yu, Hao-Wei Fang, Yi-Hong Huang, Han Lin, Jian-Jun Chen, Ming-Xia Wang, Shao-Bing Guan, Wan-Xian Lu, Xiao-Ling Chen
This case-control study was designed to establish a new risk-prediction model for primary stroke using Framingham stroke profile (FSP), cerebral vascular hemodynamic indexes (CVHI) and plasma inflammatory cytokines including hs-CRP, IL-6, TNF-α and Lp-PLA2. A total of 101 primary stroke patients admitted to Dongguan Houjie Hospital between August 2014 and June 2015 were assigned into the case group, and 156 age- and gender-matched healthy subjects from the Houjie Community were allocated into the control group...
September 13, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28885575/effect-of-multi-pass-friction-stir-processing-on-mechanical-properties-for-aa2024-al%C3%A2-o%C3%A2-nanocomposites
#3
Essam Moustafa
In the present work, an aluminum metal matrix reinforced with (Al₂O₃) nanoparticles was fabricated as a surface composite sheet using friction stir processing (FSP). The effects of processing parameters on mechanical properties, hardness, and microstructure grain were investigated. The results revealed that multi-pass FSP causes a homogeneous distribution and good dispersion of Al₂O₃ in the metal matrix, and consequently an increase in the hardness of the matrix composites. A finer grain is observed in the microstructure examination in specimens subjected to second and third passes of FSP...
September 8, 2017: Materials
https://www.readbyqxmd.com/read/28846982/mir-200a-modulates-tgf-%C3%AE-1-induced-endothelial-to-mesenchymal-shift-via-suppression-of-grb2-in-haecs
#4
Hao Zhang, Jianguo Hu, Liming Liu
Endothelial-mesenchymal transition (EndMT) is closely associated with embryogenesis, injury restitution, tissue neogenesis, tumor progressions and viscera fibrosis. EndMT may occur in the proximal tubular endothelial cells, inducing fibroblasts to produce matrix and then accelerating the process of cardiac fibrosis. Transforming growth factor-β1 (TGF-β1), a profibrotic cytokine, was recently shown to be a crucial trigger of EndMT in tubular endothelial cells. Increasing evidence suggests that growth factor receptor-bound 2 (GRB2) dysfunction affects fibrocytes; thus, GRB2 may be a novel target for treating fibrosis...
August 25, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28839995/clinical-and-genetic-study-of-a-large-chinese-family-presented-with-familial-spontaneous-pneumothorax
#5
Huajie Xing, Yanguo Liu, Guanchao Jiang, Xiao Li, Yanyan Hou, Fan Yang, Jun Wang
BACKGROUND: Familial spontaneous pneumothorax (FSP) is an inherited disease, and Birt-Hogg-Dubé (BHD) syndrome is its leading cause. BHD syndrome is an autosomal dominant disorder characterized by pulmonary cysts, spontaneous pneumothorax, renal cancer, and skin fibrofolliculomas. It is caused by germline mutations in the FLCN gene. Thus far a variety of mutations have been reported; however, the unique characteristics of BHD syndrome-related FSP are still unclear. METHOD: We reviewed the family history of a large Chinese family that presented with FSP...
July 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28832878/development-of-phase-locking-and-frequency-representation-in-the-infant-frequency-following-response
#6
Katlyn B Van Dyke, Rachel Lieberman, Alessandro Presacco, Samira Anderson
Purpose: This study investigates the development of phase locking and frequency representation in infants using the frequency-following response to consonant-vowel syllables. Method: The frequency-following response was recorded in 56 infants and 15 young adults to 2 speech syllables (/ba/ and /ga/), which were presented in randomized order to the right ear. Signal-to-noise ratio and Fsp analyses were used to verify that individual responses were present above the noise floor...
August 22, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28804538/exendin-4-assisted-adipose-derived-mesenchymal-stem-cell-therapy-protects-renal-function-against-co-existing-acute-kidney-ischemia-reperfusion-injury-and-severe-sepsis-syndrome-in-rat
#7
Pei-Hsun Sung, Hsin-Ju Chiang, Christopher Glenn Wallace, Chih-Chao Yang, Yen-Ta Chen, Kuan-Hung Chen, Chih-Hung Chen, Pei-Lin Shao, Yung-Lung Chen, Sarah Chua, Han-Tan Chai, Yi-Ling Chen, Tien-Hung Huang, Hon-Kan Yip, Mel S Lee
This study tested the hypothesis that combined therapy with exendin-4 (Ex4) and autologous adipose-derived mesenchymal stem cells (ADMSCs) was superior to either alone for protecting renal function against acute kidney ischemia-reperfusion (IR; 40-min ischemia/27-h reperfusion) injury when complicated by sepsis syndrome (SS; by cecal-ligation-puncture). Adult-male Sprague-Dawley rats (n=40) were equally divided into group 1 (sham-control), group 2 (IR-SS), group 3 (IR-SS + Ex4, 10 μg/kg subcutaneously 30 min after reperfusion and daily for 3 days), group 4 [IR-SS + ADMSC (1...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28795560/pdi-derivative-through-fine-tuning-molecular-structure-for-fullerene-free-organic-solar-cells
#8
Hua Sun, Xin Song, Jian Xie, Po Sun, Peiyang Gu, Chang Mei Liu, Fei Chen, Qi Chun Zhang, Zhi-Kuan Chen, Wei Huang
A perylenediimide (PDI)-based small molecular (SM) acceptor with both an extended π-conjugation and a three dimensional structure concurrently is critical for achieving high performance PDI-based fullerene-free organic solar cells (OSCs). In this work, we designed and synthesized a novel PDI-based SM acceptor possessing both characteristics by fusing PDI units with a spiro core of 4,4'-spirobi[cyclopenta[2,1-b;3,4-b']dithiophene(SCPDT) through the -position of the thiophene rings. An enhanced strong absorption in the range of 350-520 nm and arisen LUMO energy level of FSP was observed, compared with previous reported acceptor SCPDT-PDI4, in which the PDI units and SCPDT are not fused...
August 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28780339/the-silanol-content-and-in-vitro-cytolytic-activity-of-flame-made-silica
#9
Anastasia Spyrogianni, Inge K Herrmann, Kerda Keevend, Sotiris E Pratsinis, Karsten Wegner
HYPOTHESIS: The surface chemistry of synthetic amorphous silicas is essential for their applicational performance and for understanding their interactions with biological matter. Synthesis of silica by flame spray pyrolysis (FSP) allows to control the content and type of hydroxyl groups which also affects the cytolytic activity. EXPERIMENTS: By controlling the FSP process variables, silica nanoparticles with the same specific surface area but different surface chemistry and content of internal silanols are prepared by combustion of hexamethyldisiloxane sprays, as characterized by Raman and infrared spectroscopy, thermogravimetric analysis, and titration with lithium alanate...
July 27, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28776708/the-effect-of-category-learning-on-visual-attention-and-visual-representation
#10
Jonathan R Folstein, Shamsi S Monfared, Trevor Maravel
Subordinate-level category learning recruits neural resources associated with perceptual expertise, including the N250 component of the ERP, a posterolateral negative wave maximal between 230 and 330 ms. The N250 is a relatively late visual ERP and could plausibly be driven by attention to the features of categorized objects. Indeed, it has a latency and scalp distribution similar to the selection negativity (SN), an ERP component long known to be sensitive to attentional selection of target features. To clarify sensitivity of the N250 to attention and to more generally investigate the effect of category learning on attentional modulation of learned features, we independently manipulated subordinate-level category learning and target detection in a speeded paradigm designed to optimally elicit the SN and accompanying frontal selection positivity (FSP)...
August 4, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28772614/ductility-improvement-of-an-az61-magnesium-alloy-through-two-pass-submerged-friction-stir-processing
#11
Xicai Luo, Genghua Cao, Wen Zhang, Cheng Qiu, Datong Zhang
Friction stir processing (FSP) has been considered as a novel technique to refine the grain size and homogenize the microstructure of metallic materials. In this study, two-pass FSP was conducted under water to enhance the cooling rate during processing, and an AZ61 magnesium alloy with fine-grained and homogeneous microstructure was prepared through this method. Compared to the as-cast material, one-pass FSP resulted in grain refinement and the β-Mg17Al12 phase was broken into small particles. Using a smaller stirring tool and an overlapping ratio of 100%, a finer and more uniform microstructure with an average grain size of 4...
March 2, 2017: Materials
https://www.readbyqxmd.com/read/28761704/cpr-performance-in-the-presence-of-audiovisual-feedback-or-football-shoulder-pads
#12
Shota Tanaka, Wayne Rodrigues, Susan Sotir, Ryo Sagisaka, Hideharu Tanaka
OBJECTIVE: The initiation of cardiopulmonary resuscitation (CPR) can be complicated by the use of protective equipment in contact sports, and the rate of success in resuscitating the patient depends on the time from incident to start of CPR. The aim of our study was to see if (1) previous training, (2) the presence of audiovisual feedback and (3) the presence of football shoulder pads (FSP) affected the quality of chest compressions. METHODS: Six basic life support certified athletic training students (BLS-ATS), six basic life support certified emergency medical service personnel (BLS-EMS) and six advanced cardiac life support certified emergency medical service personnel (ACLS-EMS) participated in a crossover manikin study...
2017: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/28735624/the-effect-of-prostaglandin-e2-receptor-ptger2-activation-on-growth-factor-expression-and-cell-proliferation-in-bovine-endometrial-explants
#13
Shuangyi Zhang, Bo Liu, Wei Mao, Qianru Li, Changqi Fu, Nan Zhang, Ying Zhang, Long Gao, Yuan Shen, Jinshan Cao
The domestic animal endometrium undergoes regular periods of regeneration and degeneration during cycles of oestrus and dioestrus. If blastocyst implantation occurs in the uterus, the endometrium will prepare for pregnancy by changing its pattern of development to build a connection with the embryo to nourish it. Prostaglandin E2 (PGE2) secretion synchronized with endometrial growth in these processes and could be involved in endometrial growth. One of the PGE2 receptors (PTGER2) is present in endometrium and its increased expression accompanies with endometrial growth in above processes...
July 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28687621/cancer-associated-fibroblasts-share-characteristics-and-protumorigenic-activity-with-mesenchymal-stromal-cells
#14
Lucia Borriello, Rie Nakata, Michael A Sheard, G Esteban Fernandez, Richard Sposto, Jemily Malvar, Laurence Blavier, Hiroyuki Shimada, Shahab Asgharzadeh, Robert C Seeger, Yves A DeClerck
Cancer-associated fibroblasts (CAF) have been suggested to originate from mesenchymal stromal cells (MSC), but their relationship with MSCs is not clear. Here, we have isolated from primary human neuroblastoma tumors a population of αFAP- and FSP-1-expressing CAFs that share phenotypic and functional characteristics with bone marrow-derived MSCs (BM-MSC). Analysis of human neuroblastoma tumors also confirmed the presence of αFAP- and FSP-1-positive cells in the tumor stroma, and their presence correlated with that of M2 tumor-associated macrophages...
September 15, 2017: Cancer Research
https://www.readbyqxmd.com/read/28572729/efficacy-of-radiosensitizing-doped-titania-nanoparticles-under-hypoxia-and-preparation-of-an-embolic-microparticle
#15
Rachel A Morrison, Malgorzata J Rybak-Smith, James M Thompson, Bénédicte Thiebaut, Mark A Hill, Helen E Townley
The aim of this study was to develop a manufacturing protocol for large-scale production of doped titania radiosensitizing nanoparticles (NPs) to establish their activity under hypoxia and to produce a multimodal radiosensitizing embolic particle for cancer treatment. We have previously shown that radiosensitizing NPs can be synthesized from titania doped with rare earth elements, especially gadolinium. To translate this technology to the clinic, a crucial step is to find a suitable, scalable, high-throughput method...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28560004/impact-of-impaired-cardiac-function-on-the-progression-of-chronic-kidney-disease-role-of-pharmacomodulation-of-valsartan
#16
Chih-Chao Yang, Hon-Kan Yip, Kuan-Hung Chen, Cheuk-Kwan Sun, Yen-Ta Chen, Han-Tan Chai, Pei-Hsun Sung, Hsin-Ju Chiang, Sheung-Fat Ko, Sheng-Ying Chung, Chih-Hung Chen, Kun-Chen Lin, Pao-Yuan Lin, Jiunn-Jye Sheu
Although chronic kidney disease (CKD) is known to aggravate cardiovascular disease in the setting of cardiorenal syndrome (CRS), the impact of impaired cardiac function on the progression of CKD has seldom been reported. This study tested the impact of acute myocardial infarction on a rodent CKD model and the therapeutic effect of valsartan in this setting. Adult male Sprague-Dawley rats (n = 50) equally divided into group 1 (sham control), group 2 (CKD induced by 5/6 nephrectomy), group 3 (AMI by ligation of left coronary artery), group 4 (CKD+AMI), group 5 (CKD+AMI+valsartan, orally 10 mg/kg/day)...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28549469/are-children-participating-in-a-quasi-experimental-education-outside-the-classroom-intervention-more-physically-active
#17
Mikkel Bo Schneller, Scott Duncan, Jasper Schipperijn, Glen Nielsen, Erik Mygind, Peter Bentsen
BACKGROUND: Education outside the classroom (EOtC) is a curriculum-based approach to teaching that has shown positive associations with children's physical activity and academic learning in small-scale case studies. The purpose of this large-scale quasi-experimental study was to determine if children who participate regularly in EOtC spend more time being physically active than children who do not. METHODS: In the 2014/2015 study TEACHOUT, classes were recruited in pairs such that each EOtC class had a non-EOtC comparison class at the same school and grade level...
May 26, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28539335/special-k-once-the-fun-is-over-an-emt-arrives-for-the-bladder
#18
Warren G Hill, Weiqun Yu
Wang et al. report that in rats exposed to daily ketamine for sixteen weeks, the urothelium begins to undergo phenoconversion to a more mesenchymal state. This epithelial to mesenchymal transition (EMT), has several classic molecular hallmarks and Wang et al. demonstrate convincingly that a number of these including downregulation of E-cadherin, upregulation of mesenchymal markers vimentin and fibroblast specific protein (FSP-1), colocalization of both epithelial and mesenchymal markers in a subset of urothelium-associated cells and upregulation of TGFβ expression in urothelium are all present...
May 24, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28533326/prostaglandin-e-receptor-subtype-4-regulates-lipid-droplet-size-and-mitochondrial-activity-in-murine-subcutaneous-white-adipose-tissue
#19
Fan Ying, Yin Cai, Yu Cai, Yu Wang, Eva Hoi Ching Tang
The purpose of this study was to investigate whether genetic ablation of prostaglandin E receptor subtype 4 (EP4) affects white adipose tissue (WAT) remodeling mediated by β3-adrenergic stimulation. The selective β3-adrenergic agonist, CL316243 (1 mg/kg/d, i.p.) caused a greater increase in metabolic rate in EP4-knockout mice. CL316243 fragmented the unilocular lipid droplet into multilocular lipid vacuoles and increased mitochondrial biogenesis and its activity. These changes were amplified in mice with EP4 deficiency and were selectively seen in subcutaneous WAT...
May 22, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28457731/expression-pattern-of-cancer-associated-fibroblast-and-its-clinical-relevance-in-intrahepatic-cholangiocarcinoma
#20
Xiao-Fang Zhang, Min Dong, Yu-Hang Pan, Jian-Ning Chen, Xiang-Qi Huang, Yi Jin, Chun-Kui Shao
Intrahepatic cholangiocarcinoma (ICC) is a highly malignant neoplasm and lacks of effective treatment, characterized by dense desmoplastic stroma rich in cancer-associated fibroblasts (CAFs), which have been indicated to facilitate tumor progression in several types of human cancer. However, the clinical relevance of CAFs in ICC has not been fully characterized. Here, we evaluated the histological phenotype of CAFs and immunohistochemical expressions of α-SMA, FSP-1, and PDGFRβ in 71 ICC cases, and found that immature CAF phenotype was significantly associated with lymph node metastasis (P=...
April 27, 2017: Human Pathology
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