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https://www.readbyqxmd.com/read/29341203/food-specific-inhibitory-control-under-negative-mood-in-binge-eating-disorder-evidence-from-a-multimethod-approach
#1
Elisabeth J Leehr, Kathrin Schag, Thomas Dresler, Moritz Grosse-Wentrup, Martin Hautzinger, Andreas J Fallgatter, Stephan Zipfel, Katrin E Giel, Ann-Christine Ehlis
OBJECTIVE: Inhibitory control has been discussed as a developmental and maintenance factor in binge-eating disorder (BED). The current study is the first aimed at investigating inhibitory control in a negative mood condition on a psychophysiological and behavioral level in BED with a combination of electroencephalography (EEG) and eye tracking (ET). METHOD: We conducted a combined EEG and ET study with overweight individuals with BED (BED+, n = 24, mean age = 31, mean BMI = 35 kg/m2 ) and without BED (BED-, n = 23, mean age = 28, mean BMI = 35 kg/m2 ) and a normal-weight (NWC, n = 26, mean age 28, mean BMI = 22 kg/m2 ) control group...
January 17, 2018: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/29339667/improving-laboratory-assessment-in-disorders-of-sex-development-through-a-multidisciplinary-network
#2
Sabine E Hannema, Yolanda B de Rijke
The aim of the European Reference Network for Rare Endocrine Disorders (Endo-ERN) is to ensure equal access to high-quality care for all those affected by a rare endocrine condition across Europe, such as a disorder/difference of sex development (DSD), both for children and adults. Although differences in resources, health care systems, and health insurances between the European countries are challenging and require political action, a European laboratory network within Endo-ERN could improve the diagnostic process in individuals with DSD, building on the work done by previous European collaborations such as the COST action DSDnet...
January 17, 2018: Sexual Development: Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation
https://www.readbyqxmd.com/read/29330170/retrospective-review-of-synacthen-testing-in-infants
#3
Timothy Shao Ern Tan, Claire Manfredonia, Rakesh Kumar, Julie Jones, Elaine O'Shea, Raja Padidela, Mars Skae, Sarah Ehtisham, Fiona Ivison, Lesley Tetlow, Peter E Clayton, Indraneel Banerjee, Leena Patel
BACKGROUND: A subnormal cortisol response (30 min level (C30min)<550 nmol/L) to synthetic adrenocorticotrophic hormone/Synacthen test (SDST) in all infants does not necessarily indicate underlying or persistent hypothalamic-pituitary-adrenal axis pathology. METHODS: We retrospectively evaluated the diagnoses and outcomes in 68 infants who had a SDST at age <6 months from 2011 to 2014. RESULTS: 29 (43%) infants had a subnormal SDST...
January 12, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29326319/cross-infection-risk-in-patients-with-bronchiectasis-a-position-statement-from-the-european-bronchiectasis-network-embarc-embarc-elf-patient-advisory-group-and-european-reference-network-ern-lung-bronchiectasis-network
#4
EDITORIAL
James D Chalmers, Felix C Ringshausen, Bridget Harris, J Stuart Elborn, Annette Posthumus, Charles S Haworth, Nicola Pilkington, Eva Polverino, Thomas Ruddy, Stefano Aliberti, Pieter C Goeminne, Craig Winstanley, Anthony De Soyza
No abstract text is available yet for this article.
January 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29314759/reduced-specificity-of-erns-antibody-elisas-for-samples-from-piglets-with-maternally-derived-antibodies-induced-by-vaccination-of-sows-with-classical-swine-fever-marker-vaccine-cp7_e2alf
#5
D Meyer, W Loeffen, A Postel, S Fritsche, P Becher
Successful implementation of marker vaccines against classical swine fever virus is dependent on a reliable accompanying diagnostic assay that allows differentiation of infected from vaccinated animals (DIVA) as well as the development of a testing scheme during emergency vaccination. In this context, special attention needs to be paid to breeding farms, because the offspring of marker vaccinated sows possess maternally derived antibodies (MDAs). So far, limited information is available on the influence of MDAs on serological testing in the context of a DIVA strategy...
January 4, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29309827/adverse-childhood-experiences-are-associated-with-self-regulation-and-the-magnitude-of-the-error-related-negativity-difference
#6
Christine L Lackner, Diane L Santesso, Jane Dywan, Deborah O'Leary, Terrance J Wade, Sidney J Segalowitz
Trauma and stress, like that which occurs as a result of adverse childhood experiences (ACEs), can change brain structure and function, especially in medial prefrontal and hippocampal areas, and can impact self-regulatory skill. The error-related negativity (ERN) is a medial frontal negative event-related potential (ERP) component that is more negative when a participant makes an erroneous versus correct response. We investigated the association of ACEs to adolescents' ERN and self-regulation. Forty-three 12-15 year olds performed a flanker task while EEG data were recorded...
January 5, 2018: Biological Psychology
https://www.readbyqxmd.com/read/29307179/comparison-of-adaptive-neuroprotective-mechanisms-of-sulforaphane-and-its-interconversion-product-erucin-in-in-vitro-and-in-vivo-models-of-parkinson-s-disease
#7
Fabiana Morroni, Giulia Sita, Alice Djemil, Massimo D'Amico, Letizia Pruccoli, Giorgio Forti, Patrizia Hrelia, Andrea Tarozzi
Several studies suggest that an increase of glutathione (GSH) through activation of the transcriptional nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in the dopaminergic neurons may be a promising neuroprotective strategy in Parkinson's disease (PD). Among Nrf2 activators, isothiocyanate sulforaphane (SFN), derived from precursor glucosinolate present in Brassica vegetables, has gained attention as a potential neuroprotective compound. Bioavailability studies also suggest the contribution of SFN metabolites, including erucin (ERN), to the neuroprotective effects of SFN...
January 7, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29301739/an-uncommon-cause-of-abdominal-pain-in-a-young-man
#8
Timothy Shao Ern Tan, Foong Koon Cheah
No abstract text is available yet for this article.
January 4, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29286083/kdm3a-inhibition-attenuates-high-concentration-insulin%C3%A2-induced-vascular-smooth-muscle-cell-injury-by-suppressing-mapk-nf%C3%A2-%C3%AE%C2%BAb-pathways
#9
Bo-Fang Zhang, Hong Jiang, Jing Chen, Xin Guo, Qi Hu, Shuo Yang
Previous studies have indicated that lysine (K)‑specific demethylase 3A (KDM3A) is associated with diverse diabetes‑associated cardiovascular complications in response to high glucose levels. However, the effects of KDM3A on the pathological progression of cardiovascular injuries in response to high insulin levels remain unknown. The present study aimed to explore whether KDM3A knockdown may attenuate high insulin‑induced vascular smooth muscle cell (VSMC) dysfunction, and to further investigate the underlying mechanisms...
December 29, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29250219/use-of-acoustic-cardiography-immediately-following-electrical-cardioversion-to-predict-relapse-of-atrial-fibrillation
#10
Paul Erne, Therese J Resink, Andrea Mueller, Michael Coslovsky, Richard Kobza, David Conen, Peter Bauer, Patricia Arand
Predicting atrial fibrillation (AF) recurrence after successful electrical cardioversion (ECV) is difficult. The main aim of this study was to investigate whether acoustic cardiography (AUDICOR® 200) immediately post-ECV might provide indices for AF relapse following cardioversion. Acoustic cardiography parameters included Electromechanical Activation Time (EMAT), Left Ventricular Systolic Time (LVST), QRS duration, heart rate and third heart sound intensity (S3 Strength). We analysed data from 140 patients who underwent successful cardioversion and in whom AUDICOR results and echocardiographic measurements immediately after (baseline) ECV were available...
June 2017: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/29245296/the-clinical-surrogate-definition-of-the-trigeminocardiac-reflex-development-of-an-optimized-model-according-to-a-prisma-compliant-systematic-review
#11
Cyrill Meuwly, Tumul Chowdhury, Ricardo Gelpi, Paul Erne, Thomas Rosemann, Bernhard Schaller
BACKGROUND: The trigeminocardiac reflex (TCR) is defined as sudden onset of parasympathetic dysrhythmias including hemodynamic irregularities, apnea, and gastric hypermotility during stimulation of sensory branches of the trigeminal nerve. Since the first description of the TCR 1999, there is an ongoing discussion about a more flexible than the existing clinical definition. Aim of this work was to create a clinical surrogate definition through a systematic review of the literature. METHODS: In this meta-analysis study, literature about TCR occurrences was, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis statement, systematically identified through various search engines including PubMed (Medline), Embase (Ovid SP), and ISI Web of Sciences databases from January 2005 to August 2015...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29244199/secondary-prevention-of-recurrent-venous-thromboembolism-after-initial-oral-anticoagulation-therapy-in-patients-with-unprovoked-venous-thromboembolism
#12
REVIEW
Lindsay Robertson, Su Ern Yeoh, Ahmad Ramli
BACKGROUND: Currently, little evidence is available on the length and type of anticoagulation used for extended treatment for prevention of recurrent venous thromboembolism (VTE) in patients with unprovoked VTE who have completed initial oral anticoagulation therapy. OBJECTIVES: To compare the efficacy and safety of available oral therapeutic options (aspirin, warfarin, direct oral anticoagulants (DOACs)) for extended thromboprophylaxis in adults with a first unprovoked VTE, to prevent VTE recurrence after completion of an acceptable initial oral anticoagulant treatment period, as defined in individual studies...
December 15, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29238990/associations-between-developmental-changes-in-error-related-brain-activity-and-executive-functions-in-early-childhood
#13
Jennie K Grammer, William J Gehring, Frederick J Morrison
Behavioral evidence indicates that skills associated with children's cognitive control (e.g., response inhibition and attentional control) undergo rapid development during early childhood. A particularly important time is the transition to elementary school. Yet, at present, relatively little is known about developmental changes in the brain processes linked to cognitive control during this period, including those associated with error monitoring, including the error-related negativity (ERN) and the error positivity (Pe)...
December 14, 2017: Psychophysiology
https://www.readbyqxmd.com/read/29235980/restoration-of-glycoprotein-erns-dimerization-via-pseudoreversion-partially-restores-virulence-of-classical-swine-fever-virus
#14
Anna Katharina Tucakov, Sabine Yavuz, Eva-Maria Schürmann, Manjula Mischler, Anne Klingebeil, Gregor Meyers
The classical swine fever virus (CSFV) represents one of the most important pathogens of swine. The CSFV glycoprotein Erns is an essential structural protein and an important virulence factor. The latter is dependent on the RNase activity of this envelope protein and, most likely, its secretion from the infected cell. A further important feature with regard to its function as a virulence factor is the formation of disulfide-linked Erns homodimers that are found in virus-infected cells and virions. Mutant CSFV lacking cysteine (Cys) 171, the residue responsible for intermolecular disulfide bond formation, were found to be attenuated in pigs (Tews BA, Schürmann EM, Meyers G...
December 13, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/29227818/neutrophil-lymphocyte-ratio-kinetics-in-patients-with-advanced-solid-tumours-on-phase-i-trials-of-pd-1-pd-l1-inhibitors
#15
Malaka Ameratunga, Maxime Chénard-Poirier, Irene Moreno Candilejo, Manuel Pedregal, Andrew Lui, David Dolling, Caterina Aversa, Alvaro Ingles Garces, Joo Ern Ang, Udai Banerji, Stan Kaye, Hui Gan, Bernard Doger, Victor Moreno, Johann de Bono, Juanita Lopez
BACKGROUND: Although the neutrophil-lymphocyte ratio (NLR) is prognostic in many oncological settings, its significance in the immunotherapy era is unknown. Mechanistically, PD-1/PD-L1 inhibitors may alter NLR. We sought to characterise NLR kinetics in patients with advanced solid tumours treated with PD-1/PD-L1 inhibitors. METHODS: Electronic records of patients treated with PD-1/PD-L1 inhibitors on phase I trials across three sites were reviewed. A high NLR (hNLR) was predefined as >5...
January 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29226966/using-trial-level-data-and-multilevel-modeling-to-investigate-within-task-change-in-event-related-potentials
#16
Hannah I Volpert-Esmond, Edgar C Merkle, Meredith P Levsen, Tiffany A Ito, Bruce D Bartholow
EEG data, and specifically the ERP, provide psychologists with the power to examine quickly occurring cognitive processes at the native temporal resolution at which they occur. Despite the advantages conferred by ERPs to examine processes at different points in time, ERP researchers commonly ignore the trial-to-trial temporal dimension by collapsing across trials of similar types (i.e., the signal averaging approach) because of constraints imposed by repeated measures ANOVA. Here, we present the advantages of using multilevel modeling (MLM) to examine trial-level data to investigate change in neurocognitive processes across the course of an experiment...
December 11, 2017: Psychophysiology
https://www.readbyqxmd.com/read/29222592/circadian-dependence-of-manual-thrombus-aspiration-benefit-in-patients-with-st-segment-elevation-myocardial-infarction-undergoing-primary-percutaneous-coronary-intervention
#17
Stephane Fournier, Olivier Muller, Umberto Benedetto, Marco Roffi, Thomas Pilgrim, Franz R Eberli, Hans Rickli, Dragana Radovanovic, Paul Erne, Stéphane Cook, Stéphane Noble, Rachel Fesselet, Andrea Zuffi, Sophie Degrauwe, PierGiorgio Masci, Stephan Windecker, Eric Eeckhout, Juan F Iglesias
BACKGROUND: The clinical benefit of manual thrombus aspiration (TA) during primary percutaneous coronary intervention (PPCI) in patients with ST-segment elevation myocardial infarction (STEMI) remains uncertain. This study assessed the impact of circadian rhythms on the effectiveness of manual TA. METHODS AND RESULTS: We conducted an observational study of patients enrolled in the Acute Myocardial Infarction in Switzerland Plus registry. STEMI patients undergoing PPCI with (TA group) or without (PCI-alone group) manual TA were divided based on time-of-day symptom onset: group 1 (00:00-05:59), group 2 (06:00-11:59), group 3 (12:00-17:59) and group 4 (18:00-23:59)...
December 8, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29214567/natural-history-trial-readiness-and-gene-discovery-advances-in-patient-registries-for-neuromuscular-disease
#18
Rachel Thompson, Agata Robertson, Hanns Lochmüller
Inherited neuromuscular diseases (NMDs) are genetic disorders that affect the skeletal muscles or the nerves controlling muscle function. With a new generation of diagnostic options and recent advances in translational research improving the opportunities for therapy development for these rare conditions, capturing patient information in databases collecting a range of clinical and genetic data together with contact details has assumed an increasingly important role in trial planning and recruitment as well as natural history data collection...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29210194/error-related-brain-activity-and-anxiety-symptoms-in-youth-with-autism-spectrum-disorder
#19
Tamara E Rosen, Matthew D Lerner
Individuals with autism spectrum disorder (ASD) often experience symptoms associated with generalized anxiety disorder, obsessive-compulsive disorder, and social anxiety disorder. In other populations, these same symptoms are associated with a larger error-related negativity (ERN), an event-related potential that reflects endogenous threat sensitivity. As such, it is possible that the ERN may relate to the clinical presentation of anxiety in ASD. However, studies examining these associations in youth with ASD have yielded mixed results...
December 6, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/29203211/qtc-interval-cardiovascular-events-and-mortality-in-patients-with-atrial-fibrillation
#20
Andreas Reusser, Steffen Blum, Stefanie Aeschbacher, Lucien Eggimann, Peter Ammann, Paul Erne, Giorgio Moschovitis, Marcello Di Valentino, Dipen Shah, Jürg Schläpfer, Samuel Manser, Tobias Reichlin, Michael Kühne, Christian Sticherling, Stefan Osswald, David Conen
BACKGROUND: A longer QTc interval has been associated with more adverse cardiovascular events and death in the general population. Little evidence is available on these relationships among patients with atrial fibrillation (AF). METHODS: We performed a prospective observational multicenter cohort study of 1413 patients with AF. A resting 12‑lead electrocardiogram (ECG) was performed at baseline. QT interval was corrected for heart rate using the Bazett formula (QTc)...
February 1, 2018: International Journal of Cardiology
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