keyword
MENU ▼
Read by QxMD icon Read
search

ERN

keyword
https://www.readbyqxmd.com/read/28433090/neural-biomarker-and-early-temperament-predict-increased-internalizing-symptoms-after-a%C3%A2-natural-disaster
#1
Alexandria Meyer, Carla Kmett Danielson, Allison P Danzig, Vickie Bhatia, Sarah R Black, Evelyn Bromet, Gabrielle Carlson, Greg Hajcak, Roman Kotov, Daniel N Klein
OBJECTIVE: Although most people will experience a traumatic event at some point in their life, only some will develop significant psychological symptoms in the aftermath. In the current study, we use a preexisting longitudinal study located in Long Island to examine the impact of Hurricane Sandy on internalizing symptoms in a large sample of children. We focused on temperamental fear and a biomarker of risk for anxiety, the error-related negativity (ERN). The ERN is a negative deflection in the event-related potential (ERP) occurring when individuals make mistakes and is increased in anxious individuals...
May 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28427482/a-genetic-variant-brain-dervied-neurotrophic-factor-bdnf-polymorphism-interacts-with-hostile-parenting-to-predict-error-related-brain-activity-and-thereby-risk-for-internalizing-disorders-in-children
#2
Alexandria Meyer, Greg Hajcak, Elizabeth Hayden, Haroon I Sheikh, Shiva M Singh, Daniel N Klein
The error-related negativity (ERN) is a negative deflection in the event-related potential occurring when individuals make mistakes, and is increased in children with internalizing psychopathology. We recently found that harsh parenting predicts a larger ERN in children, and recent work has suggested that variation in the brain-derived neurotrophic factor (BDNF) gene may moderate the impact of early life adversity. Parents and children completed measures of parenting when children were 3 years old (N = 201); 3 years later, the ERN was measured and diagnostic interviews as well as dimensional symptom measures were completed...
April 21, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28410524/cognitive-control-in-young-heavy-drinkers-an-erp-study
#3
Ingmar H A Franken, Maartje Luijten, Frederik M van der Veen, Jan W van Strien
Substance use disorders have been frequently linked to an impaired cognitive control system. Whether this impaired control is also present in young adults who heavily drink alcohol is still subject to debate. The present study investigated possible impairments in cognitive control in heavy drinkers using behavioral and electrophysiological (EEG) measures. We studied behavioral performance on an inhibitory control and an error-processing task, using a GoNogo task and an Eriksen Flanker task respectively, while ERPs (Nogo-N2/P3 and ERN/Pe) were measured in a group of heavy alcohol drinkers (n=48) and a healthy control group of light drinkers (n=49)...
March 28, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28410485/impact-of-posttraumatic-stress-symptom-dimensions-on-psychophysiological-reactivity-to-threat-and-reward
#4
Lynne Lieberman, Stephanie M Gorka, Carter J Funkhouser, Stewart A Shankman, K Luan Phan
Posttraumatic stress symptoms (PTSS) are associated with significant distress and impairment. Research has therefore focused on identifying neurobehavioral deficits that contribute to the pathophysiology of PTSS. One issue that has contributed to difficulty in identifying these deficits is the highly heterogeneous nature of PTSS. PTSS is comprised of four, factor analytically distinct dimensions of symptoms - re-experiencing, avoidance, hyperarousal, and negative cognitions and mood. It is therefore unlikely that there is one single mechanism that accounts for all of PTSS and elucidating neurobehavioral deficits associated with specific PTSS symptom dimensions may better inform clinical prevention and intervention efforts...
April 7, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28394438/stimulus-processing-and-error-monitoring-in-more-able-kindergarteners-with-autism-spectrum-disorder-asd-a-short-review-and-a-preliminary-erp-study
#5
So Hyun Kim, Jennie Grammer, Nurit Benrey, Frederick Morrison, Catherine Lord
Deficits in executive functions (EF) in individuals with autism spectrum disorder (ASD) have been identified. However, there is limited evidence about patterns of deficits in EF-related skills, especially at the neurobiological level, in young children with ASD and little is known about how these skills are related to other domains of functioning and symptom severity. In this study, we provide a focused review of EF-related Event-Related Potentials (ERP) studies in children with ASD, accompanied by preliminary data for neurophysiological correlates of EF on a child-friendly Go/No-go task...
April 10, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28392425/t-cadherin-promotes-autophagy-and-survival-in-vascular-smooth-muscle-cells-through-mek1-2-erk1-2-axis-activation
#6
Emmanouil Kyriakakis, Agne Frismantiene, Boris Dasen, Dennis Pfaff, Olga Rivero, Klaus-Peter Lesch, Paul Erne, Therese J Resink, Maria Philippova
Autophagy is an evolutionary conserved intracellular catabolic process of vital importance to cell and tissue homeostasis. Autophagy is implicated in the pathogenesis of atherosclerosis but participating cells, molecular mechanisms and functional outcomes have not been fully elucidated. T-cadherin, an atypical glycosylphosphatidylinositol-anchored member of the cadherin superfamily of adhesion molecules, is upregulated on smooth muscle cells (SMCs)(1) in atherosclerotic lesions. Here, using rat and murine aortic SMCs as experimental models, we surveyed the ability of T-cadherin to regulate autophagy in SMCs during serum-starvation stress...
April 6, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28383759/pubertal-development-and-anxiety-risk-independently-relate-to-startle-habituation-during-fear-conditioning-in-8-14-year-old-females
#7
Felicia Jackson, Brady D Nelson, Alexandria Meyer, Greg Hajcak
Reduced habituation to aversive stimuli has been observed during adolescence and may reflect an underlying mechanism of vulnerability for anxiety disorders. This study examined the startle reflex during a fear-learning task in 54 8-14-year-old girls. We examined the relationship between mean startle, startle habituation, pubertal development, and two measures linked to risk for anxiety: behavioral inhibition system (BIS) and the error-related negativity (ERN). Puberty, BIS, and the ERN were unrelated to mean startle; however, each measure modulated startle habituation...
April 6, 2017: Developmental Psychobiology
https://www.readbyqxmd.com/read/28374659/modulation-of-error-monitoring-in-obsessive-compulsive-disorder-by-individually-tailored-symptom-provocation
#8
D Roh, J-G Chang, S W Yoo, J Shin, C-H Kim
BACKGROUND: The enhanced error monitoring in patients with obsessive-compulsive disorder (OCD), typically measured with the error-related negativity (ERN), has been found to be temporally stable and independent of symptom expression. Here, we examined whether the error monitoring in patients with OCD could be experimentally modulated by individually tailored symptom provocation. METHOD: Twenty patients with OCD and 20 healthy controls performed a flanker task in which OCD-relevant or neutral pictures were presented prior to a flanker stimulus...
April 4, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28369880/comparing-the-error-related-negativity-across-groups-the-impact-of-error-and-trial-number-differences
#9
Adrian G Fischer, Tilmann A Klein, Markus Ullsperger
The error-related negativity (ERN or Ne) is increasingly being investigated as a marker discriminating interindividual factors and moves toward a surrogate marker for disorders or interventions. Although reproducibility and validity of neuroscientific and psychological research has been criticized, clear data on how different quantification methods of the ERN and their relation to available trial numbers affect within- and across-participant studies is sparse. Within a large sample of 863 healthy human participants, we demonstrate that, across participants, the number of errors correlates with the amplitude of the ERN independently of the number of errors included in ERN quantification per participant, constituting a possible confound when such variance is unaccounted for...
April 3, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28368916/topical-negative-pressure-wound-therapy-of-burned-hands-functional-outcomes
#10
Denis Ehrl, Paul I Heidekrueger, P Niclas Broer, Holger C Erne
Extensive partial- and full-thickness burns, especially of the hands, continue to pose a surgical challenge. With improved knowledge regarding fluid balance, burn pathophysiology, and lately also given the introduction of topical negative pressure wound (TNPW) therapy, treatment regimes have changed in many burn centers. The authors evaluated the results regarding long-term outcomes of patients with partial- and full-thickness burns of the hands treated with TNPW. Over a period of 72 months, 51 patients with 80 hand burns received TNPW treatment...
March 31, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28363601/methylglyoxal-induced-ampk-activation-leads-to-autophagic-degradation-of-thioredoxin-1-and-glyoxalase-2-in-ht22-nerve-cells
#11
Alcir Luiz Dafre, Ariana Ern Schmitz, Pamela Maher
Methylglyoxal (MGO) is a major glycating agent that reacts with basic residues of proteins and promotes the formation of advanced glycation end products which are believed to play key roles in a number of pathologies, such as diabetes, Alzheimer's disease, and inflammation. We previously showed that MGO treatment targets the thioredoxin and the glyoxalase systems, leading to a decrease in Trx1 and Glo2 proteins in immortalized mouse hippocampal HT22 nerve cells. Here, we propose that autophagy is the underlying mechanism leading to Glo2 and Trx1 loss induced by MGO...
March 29, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28362353/ergosteryl-2-naphthoate-an-ergosterol-derivative-exhibits-antidepressant-effects-mediated-by-the-modification-of-gabaergic-and-glutamatergic-systems
#12
Mingzhu Lin, Haijun Li, Yan Zhao, Enbo Cai, Hongyan Zhu, Yugang Gao, Shuangli Liu, He Yang, Lianxue Zhang, Guosheng Tang, Ruiqing Wang
Phytosterols are a kind of natural component including sitosterol, campesterol, avenasterol, ergosterol (Er) and others. Their main natural sources are vegetable oils and their processed products, followed by grains, by-products of cereals and nuts, and small amounts of fruits, vegetables and mushrooms. In this study, three new Er monoester derivatives were obtained from the reflux reaction with Er: organic acids (furoic acid, salicylic acid and 2-naphthoic acid), 1-Ethylethyl-3-(3-dimethyllaminopropyl) carbodiimide hydrochloride (EDCI) and 4-dimethylaminopyridine (DMAP) in dichloromethane...
March 31, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28336512/an-easily-mistaken-pulmonary-opacity
#13
Timothy Shao Ern Tan, Omar Abdulla
No abstract text is available yet for this article.
March 23, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28329196/diabetic-patients-with-acute-coronary-syndromes-in-contemporary-european-registries-characteristics-and-outcomes
#14
Maddalena Lettino, Pontus Andell, Uwe Zeymer, Petr Widimsky, Nicolas Danchin, Alfredo Bardaji, Jose A Barrabes, Angel Cequier, Marc J Claeys, Leonardo De Luca, Jakob Dörler, David Erlinge, Paul Erne, Patrick Goldstein, Sasha M Koul, Gilles Lemesle, Thomas F Lüscher, Christian M Matter, Gilles Montalescot, Dragana Radovanovic, Jose Lopez Sendón, Petr Tousek, Franz Weidinger, Clive F M Weston, Azfar Zaman, Jin Li, J Wouter Jukema
Aims: Among patients with acute coronary syndromes (ACS), those with diabetes mellitus (DM) are at particularly high risk of recurrent cardiovascular events and premature death. We aimed to provide a descriptive overview of unadjusted analyses of patient characteristics, ACS management, and outcomes up to 1 year after hospital admission for an ACS/index-ACS event, in patients with DM in contemporary registries in Europe. Methods and results: A total of 10 registries provided data in a systematic manner on ACS patients with DM (total n =28 899), and without DM (total n= 97 505)...
March 10, 2017: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/28322423/uptake-of-non-vitamin-k-antagonist-oral-anti-coagulants-in-patients-with-atrial-fibrillation-a-prospective-cohort-study
#15
Matylda Zimny, Steffen Blum, Peter Ammann, Paul Erne, Giorgio Moschovitis, Marcello Di Valentino, Dipen Shah, Jürg Schläpfer, Cyrill Vogt, Alexandra Tabord, Michael Kühne, Christian Sticherling, Stefan Osswald, David Conen
AIMS: We aimed to assess the uptake of non-vitamin K antagonist oral anticoagulants (NOACs) among patients with atrial fibrillation between 2010 and 2015 in Switzerland. METHODS: We performed a prospective observational cohort study. At the baseline examination and during yearly follow-ups, we used questionnaires to obtain information about clinical characteristics and antithrombotic treatment. Stroke risk was assessed using the CHA2DS2-VASc score. RESULTS: 1545 patients were enrolled across seven centres in Switzerland...
March 21, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28322418/associations-of-sodium-potassium-and-protein-intake-with-blood-pressure-and-hypertension-in-switzerland
#16
Nicolas Glatz, Aline Chappuis, David Conen, Paul Erne, Antoinette Péchère-Bertschi, Idris Guessous, Valentina Forni, Luca Gabutti, Franco Muggli, Augusto Gallino, Daniel Hayoz, Isabelle Binet, Paolo Suter, Fred Paccaud, Murielle Bochud, Michel Burnier
BACKGROUND: Nutritional factors play an important role in the regulation of blood pressure and in the development of hypertension. In this analysis, we explored the associations of 24-hour urinary Na+, K+ and urea excretion with blood pressure levels and the risk of hypertension in the Swiss population, taking regional linguistic differences into account. METHODS: The Swiss Survey on Salt is a population based cross-sectional study that included 1336 subjects from the three main linguistic regions (French, German and Italian) of Switzerland...
March 21, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28284803/error-detection-across-the-adult-lifespan-electrophysiological-evidence-for-age-related-deficits
#17
Eva Niessen, Gereon R Fink, Heide E M Hoffmann, Peter H Weiss, Jutta Stahl
With increasing age, cognitive control processes steadily decline. Prior research suggests that healthy older adults have a generally intact performance monitoring system, but show specific deficits in error awareness, i.e., the ability to detect committed errors. We examined the neural processing of errors across the adult lifespan (69 participants; age range 20-72 years) by analysing the error (-related) negativity (Ne/ERN) and the error positivity (Pe) using an adapted version of the Go/Nogo task. At a stable overall error rate, higher age was associated with a greater proportion of undetected errors...
March 8, 2017: NeuroImage
https://www.readbyqxmd.com/read/28277759/acute-dyspnoea-in-a-paraplegic-man
#18
Timothy Shao Ern Tan, Saad Ahmad
No abstract text is available yet for this article.
March 2, 2017: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/28275837/-european-reference-networks-consequences-for-healthcare-in-germany
#19
Holm Graessner, Franz Schäfer, Maurizio Scarpa, Thomas O F Wagner
Starting in 2017, European Reference Networks (ERNs) for rare disease patients will be established in the European Union. ERNs will pool expertise in clinical centres and will establish cross-border exchange mechanisms in order to facilitate access to diagnosis and care. The integration of ERNs in the German healthcare system will pose a significant challenge. The main issues include: (i) competition between national and European interests in the conflict of national responsibility and intended cross-border availability of healthcare services, (ii) the lack of a funding concept, and (iii) the establishment of ERNs in EU member states in which implementation of national action plans for people with rare diseases is lagging behind...
March 8, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28261449/happy-to-breed-in-the-city-urban-food-resources-limit-reproductive-output-in-western-jackdaws
#20
Eva Meyrier, Lukas Jenni, Yves Bötsch, Stephan Strebel, Bruno Erne, Zulima Tablado
Urban areas expand worldwide, transforming landscapes and creating new challenging habitats. Some bird species, mainly omnivorous feeding on human waste and cavity nesters, commonly breed in these habitats and are, therefore, regarded as urban-adapted. Although urban areas may provide new nesting sites and abundant human waste, the low breeding success found in some of these species suggests that the poor protein content in human waste might limit breeding parameters. We investigated whether the breeding success of a cavity nester and omnivorous species commonly breeding in urban areas, the Western Jackdaw (Corvus monedula), depended on the availability of good-quality non-urban food...
March 2017: Ecology and Evolution
keyword
keyword
18069
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"