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https://www.readbyqxmd.com/read/28928183/assessing-the-extent-of-drug-interactions-among-patients-with-multimorbidity-in-primary-and-secondary-care-in-the-west-midlands-uk-a-study-protocol-for-the-mixed-methods-multimorbidity-study-mimms
#1
Ruth Backman, Philip Weber, Alice M Turner, Mark Lee, Ian Litchfield
INTRODUCTION: The numbers of patients with three or more chronic conditions (multimorbidity) are increasing, and will rise to 2.9 million by 2018 in the UK alone. Currently in the UK, conditions are mainly managed using over 250 sets of single-condition guidance, which has the potential to generate conflicting recommendations for lifestyle and concurrent medication for individual patients with more than one condition. To address some of these issues, we are developing a new computer-based tool to help manage these patients more effectively...
September 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28928096/burnout-is-associated-with-changes-in-error-and-feedback-processing
#2
Patrick D Gajewski, Sylvia Boden, Gabriele Freude, Guy G Potter, Michael Falkenstein
Burnout is a pattern of complaints in individuals with emotionally demanding jobs that is often seen as a precursor of depression. One often reported symptom of burnout is cognitive decline. To analyze cognitive control and to differentiate between subclinical burnout and mild-to-moderate depression a double-blinded study was conducted that investigates changes in the processing of performance errors and feedback in a task switching paradigm. Fifty-one of 76 employees from emotionally demanding jobs showed a sufficient number of errors to be included in the analysis...
September 16, 2017: Biological Psychology
https://www.readbyqxmd.com/read/28927961/clinical-and-electrophysiological-outcomes-of-deep-tms-over-the-medial-prefrontal-and-anterior-cingulate-cortices-in-ocd-patients
#3
Lior Carmi, Uri Alyagon, Noam Barnea-Ygael, Joseph Zohar, Reuven Dar, Abraham Zangen
BACKGROUND: Obsessive Compulsive Disorder (OCD) is a chronic and disabling disorder with poor response to pharmacological treatments. Converging evidences suggest that OCD patients suffer from dysfunction of the cortico-striato-thalamo-cortical (CSTC) circuit, including in the medial prefrontal cortex (mPFC) and the anterior cingulate cortex (ACC). OBJECTIVE: To examine whether modulation of mPFC-ACC activity by deep transcranial magnetic stimulation (DTMS) affects OCD symptoms...
September 6, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28927294/treatment-of-patients-with-myocardial-infarction-depends-on-history-of-cancer
#4
Sabine Rohrmann, Fabienne Witassek, Paul Erne, Hans Rickli, Dragana Radovanovic
BACKGROUND: Although cancer treatment considerably affects cardiovascular health, little is known about how cancer patients are treated for an acute myocardial infarction. We aimed to investigate whether acute myocardial infarction patients with a history of cancer received the same guideline recommended treatment as those acute myocardial infarction patients without and whether they differ with respect to inhospital outcome. METHODS: All patients with ST-segment elevation myocardial infarction and non-ST-segment elevation myocardial infarction, enrolled between 2002 and mid-2015 in the acute myocardial infarction in Switzerland (AMIS Plus) registry with comorbidity data based on the Charlson comorbidity index were analysed...
September 1, 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/28926739/electrophysiological-correlates-of-performance-monitoring-in-binge-drinking-impaired-error-related-but-preserved-feedback-processing
#5
Séverine Lannoy, Fabien D'Hondt, Valérie Dormal, Joël Billieux, Pierre Maurage
OBJECTIVE: Performance monitoring, which allows efficient behavioral regulation using either internal (error processing) or external (feedback processing) cues, has not yet been explored in binge drinking despite its adaptive importance in everyday life, particularly in the regulation of alcohol consumption. Capitalizing on a theoretical model of risky behaviors, the present study aimed at determining the behavioral and electrophysiological correlates of the cognitive (inhibition) and motivational (reward sensitivity) systems during performance monitoring...
September 2, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28922467/intelligence-and-neurophysiological-markers-of-error-monitoring-relate-to-children-s-intellectual-humility
#6
Judith H Danovitch, Megan Fisher, Hans Schroder, David Z Hambrick, Jason Moser
This study explored developmental and individual differences in intellectual humility (IH) among 127 children ages 6-8. IH was operationalized as children's assessment of their knowledge and willingness to delegate scientific questions to experts. Children completed measures of IH, theory of mind, motivational framework, and intelligence, and neurophysiological measures indexing early (error-related negativity [ERN]) and later (error positivity [Pe]) error-monitoring processes related to cognitive control. Children's knowledge self-assessment correlated with question delegation, and older children showed greater IH than younger children...
September 18, 2017: Child Development
https://www.readbyqxmd.com/read/28922320/autologous-fat-injection-vs-lundborg%C3%A2-s-resection-arthroplasty-for-the-treatment-of-trapeziometacarpal-joint-osteoarthritis
#7
Holger Erne, Michael Cerny, Denis Ehrl, Anna T Bauer, Verena Schmauss, Philipp Moog, Niclas Broer, Steffen Loew, Daniel Schmauss
BACKGROUND: Various operative approaches exist for treatment of trapeziometacarpal joint osteoarthritis. The aim of this study was to compare the results of Lundsborg's resection arthroplasty with solely autologous fat injection. PATIENTS AND METHODS: 21 patients with symptomatic osteoarthritis of the trapeziometacarpal joint (Eaton-Littler classification stages III/IV) received either a Lundsborg's resection arthroplasty (n=12) or autologous fat injection into the trapeziometacarpal joint (n=9)...
September 14, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28920886/retinal-layer-segmentation-in-multiple-sclerosis-a-systematic-review-and-meta-analysis
#8
Axel Petzold, Laura J Balcer, Peter A Calabresi, Fiona Costello, Teresa C Frohman, Elliot M Frohman, Elena H Martinez-Lapiscina, Ari J Green, Randy Kardon, Olivier Outteryck, Friedemann Paul, Sven Schippling, Patrik Vermersch, Pablo Villoslada, Lisanne J Balk
BACKGROUND: Structural retinal imaging biomarkers are important for early recognition and monitoring of inflammation and neurodegeneration in multiple sclerosis. With the introduction of spectral domain optical coherence tomography (SD-OCT), supervised automated segmentation of individual retinal layers is possible. We aimed to investigate which retinal layers show atrophy associated with neurodegeneration in multiple sclerosis when measured with SD-OCT. METHODS: In this systematic review and meta-analysis, we searched for studies in which SD-OCT was used to look at the retina in people with multiple sclerosis with or without optic neuritis in PubMed, Web of Science, and Google Scholar between Nov 22, 1991, and April 19, 2016...
October 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28905277/on-site-phytoremediation-applicability-assessment-in-alur-ilmu-universiti-kebangsaan-malaysia-based-on-spatial-and-pollution-removal-analyses
#9
Mohd Hafiyyan Mahmud, Khai Ern Lee, Thian Lai Goh
The present paper aims to assess the phytoremediation performance based on pollution removal efficiency of the highly polluted region of Alur Ilmu urban river for its applicability of on-site treatment. Thirteen stations along Alur Ilmu were selected to produce thematic maps through spatial distribution analysis based on six water quality parameters of Malaysia's Water Quality Index (WQI) for dry and raining seasons. The maps generated were used to identify the highly polluted region for phytoremediation applicability assessment...
September 14, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28884815/the-effect-of-expressive-writing-on-the-error-related-negativity-among-individuals-with-chronic-worry
#10
Hans S Schroder, Tim P Moran, Jason S Moser
The error-related negativity (ERN), an ERP elicited immediately after errors, is enlarged among individuals with anxiety. The relationship between anxiety and enlarged ERN has spurred interest in understanding potential therapeutic benefits of decreasing its amplitude within anxious individuals. The current study used a tailored intervention-expressive writing-in an attempt to reduce the ERN among a sample of individuals with chronic worry. Consistent with hypotheses, the ERN was reduced in the expressive writing group compared to an unrelated writing control group...
September 8, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28874234/retention-and-topology-of-the-bovine-viral-diarrhea-virus-glycoprotein-e2
#11
Christina Radtke, Birke Andrea Tews
Pestiviruses are enveloped viruses that bud intracellularly. They have three envelope glycoproteins, Erns, E1, and E2. E2 is the receptor binding protein and the main target for neutralizing antibodies. Both Erns and E2 are retained intracellularly. Here, E2 of the bovine viral diarrhea virus (BVDV) strain CP7 was used to study the membrane topology and intracellular localization of the protein. E2 is localized in the ER and there was no difference between E2 expressed alone or in the context of the viral polyprotein...
September 6, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28871288/error-specific-cognitive-control-alterations-in-generalized-anxiety-disorder
#12
James F Cavanagh, Alexandria Meyer, Greg Hajcak
BACKGROUND: Trait anxiety is reliably associated with enhanced neural responses following errors: meta analyses have described how the electrophysiological response to errors known as the Error-Related Negativity (ERN) is increased in anxious individuals, particularly in relation to worry. The ERN has been related to a broader class of control signals, particularly via a common theta band denominator, but it is unknown whether worry relates to these alternative medial frontal metrics...
July 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/28867538/attention-bias-modification-reduces-neural-correlates-of-response-monitoring
#13
Brady D Nelson, Felicia Jackson, Nader Amir, Greg Hajcak
The error-related negativity (ERN) is an electrophysiological response to errors. Individual differences in the ERN have been posited to reflect sensitivity to threat and linked with risk for anxiety disorders. Attention bias modification is a promising computerized intervention that has been shown to decrease threat biases and anxiety symptoms. In the present study, we examined the impact of a single session of attention bias modification, relative to a control task, on the neural correlates of response monitoring, including the ERN, correct response negativity (CRN), and their difference (i...
September 1, 2017: Biological Psychology
https://www.readbyqxmd.com/read/28853251/-expression-and-antiviral-activity-of-a-chimeric-porcinized-monoclonal-antibody-chq06-against-e2-protein-of-classical-swine-fever-virus
#14
Shucheng Chen, Huimin Sun, Su Li, Pinghuang Liu, Jifei Ma, Huaji Qiu
Classical swine fever (CSF), one of OIE-listed diseases, is a highly contagious and economically important disease of pigs. Classical swine fever virus (CSFV) is the causative agent of CSF. The capsid (C) protein and the glycoproteins Erns, E1 and E2, are structural components of the virus. E2 is the most immunogenic protein of the CSFV glycoproteins, inducing neutralizing antibodies that provide protection against lethal CSFV challenge. In a previous study, we developed a murine MAb HQ06 against the E2 protein of CSFV...
August 25, 2017: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://www.readbyqxmd.com/read/28846789/multinodular-goiter-a-study-of-malignancy-risk-in-nondominant-nodules
#15
Jenica Su-Ern Yong, Kwok Seng Loh, Bengt Fredrik Petersson, Mark Thong
The long-standing belief that multinodular goiters are associated with a lower risk of developing into carcinoma has been challenged by the results of some recent studies. In addition, we have noticed in our practice that a sizable proportion of cancers have been arising from nondominant nodules. We performed a retrospective study of 223 cases to determine (1) the incidence of carcinoma in multinodular goiters that required surgical management in our local, predominantly Asian population and (2) the incidence of carcinoma arising from nondominant nodules...
August 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28845732/-express-kindlin-1-is-a-key-protein-in-hyperbaric-oxygen-therapy-for-the-treatment-of-neuropathic-pain
#16
Baisong Zhao, Erning He, Yongying Pan, Haiping Xu, Xingrong Song
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28840223/erratum-to-investigation-of-metabolites-for-estimating-blood-deposition-time
#17
Karolina Lech, Fan Liu, Sarah K Davies, Katrin Ackermann, Joo Ern Ang, Benita Middleton, Victoria L Revell, Florence I Raynaud, Igor Hoveijn, Roelof A Hut, Debra J Skene, Manfred Kayser
No abstract text is available yet for this article.
August 24, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28832905/effect-of-testing-for-cancer-on-cancer-and-venous-thromboembolism-vte-related-mortality-and-morbidity-in-people-with-unprovoked-vte
#18
REVIEW
Lindsay Robertson, Su Ern Yeoh, Gerard Stansby, Roshan Agarwal
BACKGROUND: Venous thromboembolism (VTE) is a collective term for two conditions: deep vein thrombosis (DVT) and pulmonary embolism (PE). A proportion of people with VTE have no underlying or immediately predisposing risk factors and the VTE is referred to as unprovoked. Unprovoked VTE can often be the first clinical manifestation of an underlying malignancy. This has raised the question of whether people with an unprovoked VTE should be investigated for an underlying cancer. Treatment for VTE is different in cancer and non-cancer patients and a correct diagnosis would ensure that people received the optimal treatment for VTE to prevent recurrence and further morbidity...
August 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28818707/a-biomarker-of-anxiety-in-children-and-adolescents-a-review-focusing-on-the-error-related-negativity-ern-and-anxiety-across-development
#19
REVIEW
Alexandria Meyer
BACKGROUND: Anxiety disorders are the most common form of psychopathology and often begin early in development. Therefore, there is interest in identifying neural biomarkers that characterize pathways leading to anxiety disorders early in the course of development. A substantial amount of work focuses on the error-related negativity (ERN) as a biomarker of anxiety. While two previous reviews have focused on the relationship of the ERN and anxiety in adults, no previous review has focused on this issue in children and adolescents...
August 8, 2017: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/28806829/-lundborg-s-resection-arthroplasty-vs-pyrocarbon-spacer-pyrocardan%C3%A2-for-the-treatment-of-trapeziometacarpal-joint-osteoarthritis-a-two-centre-study
#20
Holger C Erne, Daniel Schmauß, Michael Cerny, Verena Schmauss, Denis Ehrl, Steffen Löw, Stefan Deiler
Background Various operative approaches exist for osteoarthritis of the trapeziometacarpal joint. The aim of this two-centre study was to compare the results of Lundsborg's resection arthroplasty with the implantation of the Pyrocardan(®) spacer. Patients and methods We treated 20 patients with symptomatic osteoarthritis of the trapeziometacarpal joint in stage III / IV (Eaton-Littler classification). Twelve patients received Lundsborg's resection arthroplasty (centre 1), and in 8 patients a Pyrocardan(®) spacer was implanted (centre 2)...
August 2017: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
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