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https://www.readbyqxmd.com/read/28741307/modelling-cost-effectiveness-and-health-gains-of-a-universal-vs-prioritized-hcv-treatment-policy-in-a-real-life-cohort
#1
Loreta A Kondili, Federica Romano, Francesca Romana Rolli, Matteo Ruggeri, Stefano Rosato, Maurizia Rossana Brunetto, Anna Linda Zignego, Alessia Ciancio, Alfredo Di Leo, Giovanni Raimondo, Carlo Ferrari, Gloria Taliani, Guglielmo Borgia, Teresa Antonia Santantonio, Pierluigi Blanc, Giovanni Battista Gaeta, Antonio Gasbarrini, Luchino Chessa, Elke Maria Erne, Erica Villa, Donatella Ieluzzi, Francesco Paolo Russo, Pietro Andreone, Maria Vinci, Carmine Coppola, Liliana Chemello, Salvatore Madonia, Gabriella Verucchi, Marcello Persico, Massimo Zuin, Massimo Puoti, Alfredo Alberti, Gerardo Nardone, Marco Massari, Giuseppe Montalto, Giuseppe Foti, Maria Grazia Rumi, Maria Giovanna Quaranta, Americo Cicchetti, Antonio Craxì, Stefano Vella
We evaluated the cost-effectiveness of two alternative DAA treatment policies in a real-life cohort of HCV-infected patients: Policy 1 - "universal": treat all patients, regardless of the fibrosis stage; Policy 2 - treat only "prioritized" patients, delay treatment of the remaining patients until reaching stage F3. A liver disease progression Markov model, which used a lifetime horizon and healthcare system perspective, was applied to the PITER cohort (representative of Italian HCV-infected patients in care)...
July 24, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28735626/differentiation-of-hmsc-and-hpdlsc-induced-by-pge2-or-bmp-7-in-3d-models
#2
Christina Ern, Tamara Berger, Iris Frasheri, Richard Heym, Reinhard Hickel, Matthias Folwaczny
Regenerative therapies of pathogenic tissue defects are gaining increasing importance in periodontology. Among others, the osteogenic effect of BMP-7 seems to play a major role in the development of teeth and alveolar bone. Human periodontal ligament stem cells (hPDLSC), as well as human mesenchymal stem cells (hMSC), show the ability to differentiate into various types of tissues. Regarding prostaglandin E2, many studies have confirmed that it is involved in the inflammation associated to periodontitis stimulating osteoclasts, which ultimately leads to resorption of tooth supporting bone...
July 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28711700/the-effect-of-monetary-punishment-on-error-evaluation-in-a-go-no-go-task
#3
Yuya Maruo, Werner Sommer, Hiroaki Masaki
Little is known about the effects of the motivational significance of errors in Go/No-go tasks. We investigated the impact of monetary punishment on the error-related negativity (ERN) and error positivity (Pe) for both overt errors and partial errors, that is, no-go trials without overt responses but with covert muscle activities. We compared high and low punishment conditions where errors were penalized with 50 or 5 yen, respectively, and a control condition without monetary consequences for errors. Because we hypothesized that the partial-error ERN might overlap with the no-go N2, we compared ERPs between correct rejections (i...
July 12, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28703883/associations-between-cardiovascular-disease-and-its-risk-factors-with-hearing-loss-a-cross-sectional-analysis
#4
Hsern Ern Ivan Tan, Nick Si Rui Lan, Matthew William Knuiman, Mark Laurence Divitini, De Wet Swanepoel, Michael Hunter, Christopher Gerard Brennan-Jones, Joseph Hung, Robert Henry Eikelboom, Peter Luke Santa Maria
OBJECTIVES: To investigate the relationship between hearing loss and cardiovascular disease risk factors. DESIGN: Cross-sectional study. METHODS: Participants were recruited between May 2010 and December 2015 and answered a health and risk factor questionnaire. Physical and biochemical assessments were performed. SETTING: A community based population. PARTICIPANTS: 5,107 participants born within the years 1946-1964 enrolled in the Busselton Healthy Ageing Study...
July 13, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28701471/effects-of-hypoxia-and-ocean-acidification-on-the-upper-thermal-niche-boundaries-of-coral-reef-fishes
#5
Rasmus Ern, Jacob L Johansen, Jodie L Rummer, Andrew J Esbaugh
Rising ocean temperatures are predicted to cause a poleward shift in the distribution of marine fishes occupying the extent of latitudes tolerable within their thermal range boundaries. A prevailing theory suggests that the upper thermal limits of fishes are constrained by hypoxia and ocean acidification. However, some eurythermal fish species do not conform to this theory, and maintain their upper thermal limits in hypoxia. Here we determine if the same is true for stenothermal species. In three coral reef fish species we tested the effect of hypoxia on upper thermal limits, measured as critical thermal maximum (CTmax)...
July 2017: Biology Letters
https://www.readbyqxmd.com/read/28695548/design-of-the-swiss-atrial-fibrillation-cohort-study-swiss-af-structural-brain-damage-and-cognitive-decline-among-patients-with-atrial-fibrillation
#6
David Conen, Nicolas Rodondi, Andreas Mueller, Juerg Beer, Angelo Auricchio, Peter Ammann, Daniel Hayoz, Richard Kobza, Giorgio Moschovitis, Dipen Shah, Juerg Schlaepfer, Jan Novak, Marcello di Valentino, Paul Erne, Christian Sticherling, Leo Bonati, Georg Ehret, Laurent Roten, Urs Fischer, Andreas Monsch, Christoph Stippich, Jens Wuerfel, Matthias Schwenkglenks, Michael Kuehne, Stefan Osswald
BACKGROUND: Several studies found that patients with atrial fibrillation (AF) have an increased risk of cognitive decline and dementia over time. However, the magnitude of the problem, associated risk factors and underlying mechanisms remain unclear. METHODS: This article describes the design and methodology of the Swiss Atrial Fibrillation (Swiss-AF) Cohort Study, a prospective multicentre national cohort study of 2400 patients across 13 sites in Switzerland. Eligible patients must have documented AF...
July 11, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28694856/social-determinant-factors-and-their-relationship-with-nutritional-pattern-in-cardiovascular-patients-after-hospital-discharge
#7
Hassan Nazari, Davoud Vahabzadeh, Saeed Beygh Mohammadi, Leila Zarei, Masoud Ghahramani
INTRODUCTION: Several evidences suggest that it will be possible to reduce the risk of cardiovascular diseases by modifying its risk factors. Current study designed for identifying some social determinant factors and their relationship with nutritional pa! ern in cardiovascular patients a" er hospital discharge. METHODS: This cross-sectional study was conducted on 385 cardiovascular discharged patients from an university specialized heart educational hospital. Patients were included by simple sampling methods...
September 2016: Mædica
https://www.readbyqxmd.com/read/28675610/vitamin-d-a-modulator-of-musculoskeletal-health-in-chronic-kidney-disease
#8
REVIEW
Pablo Molina, Juan J Carrero, Jordi Bover, Philippe Chauveau, Sandro Mazzaferro, Pablo Ureña Torres
The spectrum of activity of vitamin D goes beyond calcium and bone homeostasis, and growing evidence suggests that vitamin D contributes to maintain musculoskeletal health in healthy subjects as well as in patients with chronic kidney disease (CKD), who display the combination of bone metabolism disorder, muscle wasting, and weakness. Here, we review how vitamin D represents a pathway in which bone and muscle may interact. In vitro studies have confirmed that the vitamin D receptor is present on muscle, describing the mechanisms whereby vitamin D directly affects skeletal muscle...
July 3, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/28673264/distribution-of-axial-length-in-chinese-congenital-ectopia-lentis-patients-a-retrospective-study
#9
Yichi Zhang, Guangming Jin, Qianzhong Cao, Junxiong Lin, Jianqiang Lin, Yiyao Wang, Su Ern Poh, Charlotte Aimee Young, Danying Zheng
BACKGROUND: Congenital ectopia lentis (CEL) usually leads to refractive error and may influence the axial length development. But few investigations have reported patient demographics and the distribution of axial length (AL) before surgery in Chinese pediatric patients with CEL. To describe the distribution of AL before surgery in CEL patients and its relationship with patients' demographics, such as age, Marfan syndrome, sex, and laterality. METHODS: This retrospective study reviewed 306 CEL patients from January 1, 2006 to December 31, 2015...
July 3, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28666988/prospective-assessment-of-sex-related-differences-in-symptom-status-and-health-perception-among-patients-with-atrial-fibrillation
#10
Steffen Blum, Christoph Muff, Stefanie Aeschbacher, Peter Ammann, Paul Erne, Giorgio Moschovitis, Marcello Di Valentino, Dipen Shah, Jürg Schläpfer, Andreas Fischer, Tamara Merkel, Michael Kühne, Christian Sticherling, Stefan Osswald, David Conen
BACKGROUND: We prospectively assessed sex-specific differences in health perception, overall symptom status, and specific symptoms in a large cohort of patients with atrial fibrillation. METHODS AND RESULTS: We performed a prospective multicenter observational cohort study of 1553 patients with atrial fibrillation. Patients completed questionnaires about personal characteristics, comorbidities, and symptoms on a yearly basis. Mean age was 70±11 years among women and 67±12 years among men...
June 30, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28644867/host-derived-apolipoproteins-play-comparable-roles-with-viral-secretory-proteins-erns-and-ns1-in-the-infectious-particle-formation-of-flaviviridae
#11
Takasuke Fukuhara, Tomokazu Tamura, Chikako Ono, Mai Shiokawa, Hiroyuki Mori, Kentaro Uemura, Satomi Yamamoto, Takeshi Kurihara, Toru Okamoto, Ryosuke Suzuki, Kentaro Yoshii, Takeshi Kurosu, Manabu Igarashi, Hiroshi Aoki, Yoshihiro Sakoda, Yoshiharu Matsuura
Amphipathic α-helices of exchangeable apolipoproteins have shown to play crucial roles in the formation of infectious hepatitis C virus (HCV) particles through the interaction with viral particles. Among the Flaviviridae members, pestivirus and flavivirus possess a viral structural protein Erns or a non-structural protein 1 (NS1) as secretory glycoproteins, respectively, while Hepacivirus including HCV has no secretory glycoprotein. In case of pestivirus replication, the C-terminal long amphipathic α-helices of Erns are important for anchoring to viral membrane...
June 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28640140/aldosterone-and-renin-in-cardiac-patients-referred-for-catheterization
#12
Paul Erne, Andrea Müller, Gian Paolo Rossi, Burkhardt Seifert, Fabrice Stehlin, Maurice Redondo, Peter T Bauer, Richard Kobza, Therese J Resink, Dragana Radovanovic
Little is known regarding alterations of the renin-angiotensin system in patients referred for cardiac catheterization. Here, we measured plasma levels of active renin and aldosterone in patients referred for cardiac catheterization in order to determine the prevalence of elevated renin, aldosterone, and the aldosterone-renin ratio.A chemiluminescence assay was used to measure plasma aldosterone concentration (PAC) and active renin levels in 833 consecutive patients, after an overnight fasting and without any medication for least 12 hours...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28637716/modulation-of-plasma-metabolite-biomarkers-of-mapk-pathway-with-the-mek-inhibitor-ro4987655-pharmacodynamic-and-predictive-potential-in-metastatic-melanoma
#13
Joo Ern Ang, Akos Pal, Yasmin J Asad, Alan T Henley, Melanie Valenti, Gary Box, Alexis de Haven Brandon, Victoria Revell, Debra J Skene, Miro Venturi, Ruediger Rueger, Valerie Meresse, Suzanne A Eccles, Johann S de Bono, Stanley B Kaye, Paul Workman, Udai Banerji, Florence I Raynaud
<p>MAPK pathway activation is frequently observed in human malignancies, including melanoma, and is associated with sensitivity to MEK inhibition and changes in cellular metabolism. Using quantitative mass spectrometry-based metabolomics, we identified in preclinical models 21 plasma metabolites including amino acids, propionylcarnitine, phosphatidylcholines and sphingomyelins that were significantly altered in two B-RAF mutant melanoma xenografts and that were reversed following a single dose of the potent and selective MEK inhibitor RO4987655...
June 21, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28628797/attenuated-error-related-potentials-in-amyotrophic-lateral-sclerosis-with-executive-dysfunctions
#14
Caroline Seer, Max Joop, Florian Lange, Christian Lange, Reinhard Dengler, Susanne Petri, Bruno Kopp
OBJECTIVE: Executive dysfunctions affect up to 50% of the patients with amyotrophic lateral sclerosis (ALS). Executive dysfunctions have been identified as negative prognostic factor and can affect quality of life in patients and their caregivers. Assessment of executive dysfunction may be impeded by the patients' motor impairments. Event-related potentials (ERP) have been proposed as a tool to overcome these assessment difficulties. The error(-related) negativity (Ne/ERN) is an ERP which can be recorded with minimal motor requirements for the patient...
May 18, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28621460/older-adults-display-diminished-error-processing-and-response-in-a-continuous-tracking-task
#15
Francisco L Colino, Harvey Howse, Angela Norton, Robert Trska, Anthony Pluta, Stephen J C Luehr, Todd C Handy, Olave E Krigolson
Advancing age is often accompanied by a decline in motor control that results in a decreased ability to successfully perform motor tasks. While there are multiple factors that contribute to age-related deficits in motor control, one unexplored possibility is that age-related deficits in our ability to evaluate motor output result in an increase in motor errors. In line with this, previous work from our laboratory demonstrated that motor errors evoked an error-related negativity (ERN)-a component of the human ERP associated with error evaluation originating within the human medial-frontal cortex...
June 16, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28606471/impact-of-anxiety-symptoms-and-problematic-alcohol-use-on-error-related-brain-activity
#16
Stephanie M Gorka, K Luan Phan
Anxiety disorders are associated with enhanced defensive reactivity to errors, measured via the error-related negativity (ERN). There is some evidence to suggest that problematic alcohol use is also associated with an enhanced ERN; although prior studies have been almost exclusively in men and have yet to examine the potential interactive effects of anxiety and alcohol abuse symptoms. The aim of the current study was to address the gaps in this literature by examining the unique and interactive effects of anxiety symptoms and problematic alcohol use on the ERN in a sample of 79 heterogeneous internalizing disorder patients...
June 9, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28601965/event-related-potentials-reflect-impaired-temporal-interval-learning-following-haloperidol-administration
#17
Sarah E Forster, Patrick Zirnheld, Anantha Shekhar, Stuart R Steinhauer, Brian F O'Donnell, William P Hetrick
BACKGROUND: Signals carried by the mesencephalic dopamine system and conveyed to anterior cingulate cortex are critically implicated in probabilistic reward learning and performance monitoring. A common evaluative mechanism purportedly subserves both functions, giving rise to homologous medial frontal negativities in feedback- and response-locked event-related brain potentials (the feedback-related negativity (FRN) and the error-related negativity (ERN), respectively), reflecting dopamine-dependent prediction error signals to unexpectedly negative events...
June 10, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28598569/heart-failure-in-patients-admitted-for-acute-coronary-syndromes-a-report-from-a-large-national-registry
#18
Raban V Jeger, Otmar Pfister, Dragana Radovanovic, Franz R Eberli, Hans Rickli, Philip Urban, Giovanni Pedrazzini, Jean-Christophe Stauffer, Jörg Nossen, Paul Erne
BACKGROUND: Data on temporal trends of heart failure (HF) in acute coronary syndrome (ACS) are scarce. HYPOTHESIS: Improved treatment options may have led to lower case-fatality rates (CFRs) during the last years in ACS complicated by HF. METHODS: Patients of the nationwide Acute Myocardial Infarction in Switzerland (AMIS)-Plus ACS registry were analyzed from 2000 to 2014. RESULTS: Of 36 366 ACS patients, 3376 (9.3%) had acute or chronic HF, 2111 (5...
June 9, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28584707/rituals-decrease-the-neural-response-to-performance-failure
#19
Nicholas M Hobson, Devin Bonk, Michael Inzlicht
Rituals are found in all types of performance domains, from high-stakes athletics and military to the daily morning preparations of the working family. Yet despite their ubiquity and widespread importance for humans, we know very little of ritual's causal basis and how (if at all) they facilitate goal-directed performance. Here, in a fully pre-registered pre/post experimental design, we examine a candidate proximal mechanism, the error-related negativity (ERN), in testing the prediction that ritual modulates neural performance-monitoring...
2017: PeerJ
https://www.readbyqxmd.com/read/28556905/working-memory-load-impairs-the-evaluation-of-behavioral-errors-in-the-medial-frontal-cortex
#20
Martin E Maier, Marco Steinhauser
Early error monitoring in the medial frontal cortex enables error detection and the evaluation of error significance, which helps prioritize adaptive control. This ability has been assumed to be independent from central capacity, a limited pool of resources assumed to be involved in cognitive control. The present study investigated whether error evaluation depends on central capacity by measuring the error-related negativity (Ne/ERN) in a flanker paradigm while working memory load was varied on two levels. We used a four-choice flanker paradigm in which participants had to classify targets while ignoring flankers...
May 30, 2017: Psychophysiology
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