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feedback-related negativity

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https://www.readbyqxmd.com/read/29053930/social-dimension-and-complexity-differentially-influence-brain-responses-during-feedback-processing
#1
Daniela M Pfabigan, Marianne Gittenberger, Claus Lamm
Recent research emphasizes the importance of social factors during performance monitoring. Thus, the current study investigated the impact of social stimuli -such as communicative gestures- on feedback processing. Moreover, it addressed a shortcoming of previous studies, which failed to consider stimulus complexity as potential confounding factor. Twenty-four volunteers performed a time estimation task while their electroencephalogram was recorded. Either social complex, social non-complex, non-social complex, or non-social non-complex stimuli were used to provide performance feedback...
October 20, 2017: Social Neuroscience
https://www.readbyqxmd.com/read/29053578/treatment-with-synthetic-glucocorticoids-and-the-hypothalamus-pituitary-adrenal-axis
#2
REVIEW
Rosa Maria Paragliola, Giampaolo Papi, Alfredo Pontecorvi, Salvatore Maria Corsello
Chronic glucocorticoid (GC) treatment represents a widely-prescribed therapy for several diseases in consideration of both anti-inflammatory and immunosuppressive activity but, if used at high doses for prolonged periods, it can determine the systemic effects characteristic of Cushing's syndrome. In addition to signs and symptoms of hypercortisolism, patients on chronic GC therapy are at risk to develop tertiary adrenal insufficiency after the reduction or the withdrawal of corticosteroids or during acute stress...
October 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29051138/effectiveness-of-two-web-based-interventions-for-chronic-cancer-related-fatigue-compared-to-an-active-control-condition-results-of-the-fitter-na-kanker-randomized-controlled-trial
#3
Fieke Z Bruggeman-Everts, Marije D J Wolvers, Rens van de Schoot, Miriam M R Vollenbroek-Hutten, Marije L Van der Lee
BACKGROUND: Approximately one third of all patients who have been successfully treated for cancer suffer from chronic cancer-related fatigue (CCRF). Effective and easily accessible interventions are needed for these patients. OBJECTIVE: The current paper reports on the results of a 3-armed randomized controlled trial investigating the clinical effectiveness of two different guided Web-based interventions for reducing CCRF compared to an active control condition...
October 19, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29050555/natural-variation-in-human-clocks
#4
Malcolm von Schantz
Our own species has a diurnal activity pattern and an average circadian period of 24.2h. Exact determination of circadian period requires expensive and intrusive protocols, and investigators are therefore using chronotype questionnaires as a proxy quantitative measure. Both measures show a normal distribution suggestive of a polygenic trait. The genetic components of the 24-h feedback loop that generates circadian rhythms within our cells have been mapped in detail, identifying a number of candidate genes which have been investigated for genetic polymorphisms relating to the phenotypic variance...
2017: Advances in Genetics
https://www.readbyqxmd.com/read/29045548/bold-activity-during-correct-answer-feedback-in-cued-recall-predicts-subsequent-retrieval-performance-an-fmri-investigation-using-a-partial-trial-design
#5
Adrian W Gilmore, Steven M Nelson, Farah Naaz, Ruth A Shaffer, Kathleen B McDermott
Receiving correct answer feedback following a retrieval attempt has proven to be a highly effective means of learning new information, yet the mechanisms behind its efficacy remain poorly understood. Here, fMRI was used to examine how BOLD activity measured during a period of feedback could predict subsequent memory (SM) performance on a final test. Twenty-five human subjects studied pairs of associated words, and were then asked to covertly recall target words in response to provided cues. Correct answer feedback was provided immediately after covert retrieval attempts...
October 17, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29044599/feedback-informed-treatment-an-empirically-supported-case-study-of-psychodynamic-treatment
#6
Stephanie Winkeljohn Black, Jesse Owen, Norah Chapman, Kelly Lavin, Joanna M Drinane, Patty Kuo
The use of client feedback, via self-report measures of psychological functioning and working alliance, is an effective way to improve therapy outcomes. Despite this progress, there are many questions about the mechanisms of change for these systems. The current study employed a case study approach to examine the effectiveness of feedback informed treatment within a psychodynamic therapy. We examined the case based on therapy outcomes, alliance processes, and verbatim dialogue of in-session exchanges. We also conducted a semistructured interview with the therapist to understand how she used and interpreted the feedback within her psychodynamic approach...
November 2017: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/29035907/relationship-between-pd-l1-expression-and-cd8-t-cell-immune-responses-in-hepatocellular-carcinoma
#7
Chun-Yu Huang, Ying Wang, Guang-Yu Luo, Feng Han, Yong-Qiang Li, Zhong-Guo Zhou, Guo-Liang Xu
As PD-1/PD-L1 immune checkpoint inhibitors exhibited promising clinical outcomes in various types of solid tumors, PD-1/PD-L1 blockades have been explored for the treatment of hepatocellular carcinoma (HCC). However, the association of PD-L1 with antitumor immunoregulation is not clearly defined in HCC. Here, we evaluated the characteristics of PD-L1 expression, CD8 T-cell infiltration and their relationship in HCC. A total of 411 resected tumor specimens from HCC patients were immunostained for PD-L1 and CD8...
October 13, 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/29033116/delivering-normative-feedback-to-heavy-drinking-college-students-via-text-messaging-a-pilot-feasibility-study
#8
Jennifer E Merrill, Holly K Boyle, Nancy P Barnett, Kate B Carey
Correcting misperceptions in drinking norms is an established method of reducing college student drinking; however, delivery of accurate norms has typically been limited to a single dose within the confines of an alcohol intervention. The present study tests the feasibility, acceptability, and preliminary efficacy of using text messages to promote pro-moderation descriptive and injunctive norms. Following a baseline survey, 68 heavy drinking college students were randomly assigned to receive 28 daily messages with either accurate norms information (experimental group, n=34) or fun facts (control group, n=34)...
October 5, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29032191/aging-and-a-genetic-kibra-polymorphism-interactively-affect-feedback-and-observation-based-probabilistic-classification-learning
#9
Nicolas W Schuck, Jessica R Petok, Martijn Meeter, Brit-Maren M Schjeide, Julia Schröder, Lars Bertram, Mark A Gluck, Shu-Chen Li
Probabilistic category learning involves complex interactions between the hippocampus and striatum that may depend on whether acquisition occurs via feedback or observation. Little is known about how healthy aging affects these processes. We tested whether age-related behavioral differences in probabilistic category learning from feedback or observation depend on a genetic factor known to influence individual differences in hippocampal function, the KIBRA gene (single nucleotide polymorphism rs17070145). Results showed comparable age-related performance impairments in observational as well as feedback-based learning...
September 5, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29031471/gunslingers-poker-players-and-chickens-3-decision-making-under-mental-performance-pressure-in-junior-elite-athletes
#10
Beth L Parkin, Vincent Walsh
BACKGROUND: Having investigated the decision making of world class elite and subelite athletes (see Parkin and Walsh, 2017; Parkin et al., 2017), here the abilities of those at the earliest stage of entry to elite sport are examined. Junior elite athletes have undergone initial national selection and are younger than athletes examined previously (mean age 13 years). Decision making under mental pressure is explored in this sample. During performance an athlete encounters a wide array of mental pressures; these include the psychological impact of errors, negative feedback, and requirements for sustained attention in a dynamic environment (Anshel and Wells, 2000; Mellalieu et al...
2017: Progress in Brain Research
https://www.readbyqxmd.com/read/29030987/nod1-downregulates-intestinal-serotonin-transporter-and-interacts-with-other-pattern-recognition-receptors
#11
Elena Layunta, Eva Latorre, Raquel Forcén, Laura Grasa, Miguel Ángel Plaza, Maykel Arias, Ana I Alcalde, José E Mesonero
Serotonin (5-HT) is an essential gastrointestinal modulator whose effects regulate the intestinal physiology. 5-HT effects depend on extracellular 5-HT bioavailability, which is controlled by the serotonin transporter (SERT) expressed in both the apical and basolateral membranes of enterocytes. SERT is a critical target for regulating 5-HT levels and consequently, modulating the intestinal physiology. The deregulation of innate immune receptors has been extensively studied in inflammatory bowel diseases (IBD), where an exacerbated defense response to commensal microbiota is observed...
October 14, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29028787/relationship-between-pd-l1-expression-and-cd8-t-cell-immune-responses-in-hepatocellular-carcinoma
#12
Chun-Yu Huang, Ying Wang, Guang-Yu Luo, Feng Han, Yong-Qiang Li, Zhong-Guo Zhou, Guo-Liang Xu
As PD-1/PD-L1 immune checkpoint inhibitors exhibited promising clinical outcomes in various types of solid tumors, PD-1/PD-L1 blockades have been explored for the treatment of hepatocellular carcinoma (HCC). However, the association of PD-L1 with antitumor immunoregulation is not clearly defined in HCC. Here, we evaluated the characteristics of PD-L1 expression, CD8 T-cell infiltration and their relationship in HCC. A total of 411 resected tumor specimens from HCC patients were immunostained for PD-L1 and CD8...
November 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/29027071/the-brain-s-reward-response-occurs-even-without-actual-reward
#13
A Fielding, Y Fu, E A Franz
What if the brain's response to reward occurs even when there is no reward? Wouldn't that be a further concern for people prone to problem gambling and other forms of addiction, like those related to eating? Electroencephalography was employed to investigate this possibility using probabilistic feedback manipulations and measures of known event-related potentials (ERPs) related to reward processing. We tested the hypothesis-that reward-based ERPs would occur even in the absence of a tangible reward and when manipulations on expectation are implicit...
October 12, 2017: Journal of Gambling Studies
https://www.readbyqxmd.com/read/29023568/demonstrating-the-reliability-of-transdiagnostic-mhealth-routine-outcome-monitoring-in-mental-health-services-using-experience-sampling-technology
#14
Simone J W Verhagen, Juliënne A Berben, Carsten Leue, Anne Marsman, Philippe A E G Delespaul, Jim van Os, Richel Lousberg
BACKGROUND: Routine Outcome Monitoring (ROM) should provide a dynamic, within-treatment forward feedback loop to guide individual treatment decisions across diagnostic categories. It has been suggested that the Experience Sampling Method (ESM), capturing the film of daily life adaptive processes, offers a flexible, personalised and transdiagnostic feedback system for monitoring and adapting treatment strategies. This is the first study that uses an ESM application (the PsyMate™) as a routine mobile-ROM (mROM) tool in an ambulatory mental health setting...
2017: PloS One
https://www.readbyqxmd.com/read/29021573/an-nf-%C3%AE%C2%BAb-microrna-regulatory-network-tunes-macrophage-inflammatory-responses
#15
Mati Mann, Arnav Mehta, Jimmy L Zhao, Kevin Lee, Georgi K Marinov, Yvette Garcia-Flores, David Baltimore
The innate inflammatory response must be tightly regulated to ensure effective immune protection. NF-κB is a key mediator of the inflammatory response, and its dysregulation has been associated with immune-related malignancies. Here, we describe a miRNA-based regulatory network that enables precise NF-κB activity in mouse macrophages. Elevated miR-155 expression potentiates NF-κB activity in miR-146a-deficient mice, leading to both an overactive acute inflammatory response and chronic inflammation. Enforced miR-155 expression overrides miR-146a-mediated repression of NF-κB activation, thus emphasizing the dominant function of miR-155 in promoting inflammation...
October 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/29018350/folliculin-interacts-with-rab35-to-regulate-egf-induced-egfr-degradation
#16
Jianchao Zheng, Biao Duan, Shixiu Sun, Jie Cui, Jun Du, Yujie Zhang
Aims and Hypothesis: This study aims to investigate the mechanism involved in intracellular regulation of EGFR degradation induced by EGF. Methods: Phosphorylation of proteins related to EGFR signaling was examined by western blot analysis. Activation, connection between Rab35 and folliculin (FLCN) were assessed by pulldown, coimmunoprecipitation assays separately. The relationship between FLCN and cell growth was detected using gene overexpression and knock-down techniques. Results: Here, we demonstrate that interfering with FLCN, a tumor suppressor, reduces the rate of EGF-induced EGFR degradation, resulting in prolonged activation of downstream signaling...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28993784/the-intergenic-interplay-between-aldose-1-epimerase-like-protein-and-pectin-methylesterase-in-abiotic-and-biotic-stress-control
#17
Ekaterina V Sheshukova, Tatiana V Komarova, Denis V Pozdyshev, Natalia M Ershova, Anastasia V Shindyapina, Vadim N Tashlitsky, Eugene V Sheval, Yuri L Dorokhov
The mechanical damage that often precedes the penetration of a leaf by a pathogen promotes the activation of pectin methylesterase (PME); the activation of PME leads to the emission of methanol, resulting in a "priming" effect on intact leaves, which is accompanied by an increased sensitivity to Tobacco mosaic virus (TMV) and resistance to bacteria. In this study, we revealed that mRNA levels of the methanol-inducible gene encoding Nicotiana benthamiana aldose 1-epimerase-like protein (NbAELP) in the leaves of intact plants are very low compared with roots...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28990295/job-crafting-among-health-care-professionals-the-role-of-work-engagement
#18
Arnold B Bakker
AIM: The aim of this study was to examine the impact of job crafting on the quality of the work environment of health care professionals. BACKGROUND: Job crafting refers to proactive behavior aimed at optimizing the fit between person and job. Using job demands-resources theory, we hypothesized that job crafting would be positively related to job resources and person-organisation fit, and negatively to hindrance demands. Furthermore, we hypothesized that these relationships would be qualified by work engagement...
October 9, 2017: Journal of Nursing Management
https://www.readbyqxmd.com/read/28988111/pai-1-pias3-stat3-mir-34a-forms-a-positive-feedback-loop-to-promote-emt-mediated-metastasis-through-stat3-signaling-in-non-small-cell-lung-cancer
#19
Xian Lin, Bing-Wen Lin, Xiao-Li Chen, Bei-Lei Zhang, Xiong-Jian Xiao, Jing-Shi Shi, Jian-Dong Lin, Xiao Chen
AIM: This study intented to clarify the intracellular effect of PAI-1 on Non-small cell lung cancer (NSCLC) metastasis and the precise mechanism involved. METHODS: The metastatic properties of NSCLC cells were determined by transwell assays and wound-healing assay in vitro. The mRNA and protein expressions of genes were analyzed by Real-time qPCR and western blot, respectively. Pulmonary metastasis model of NSCLC cells was established to evaluate the pro-metastasis effect of PAI-1 and anti-metastatic effect of miR-34a in vivo...
October 5, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28985443/kv-channels-and-the-regulation-of-vascular-smooth-muscle-tone
#20
William F Jackson
Vascular smooth muscle cells (VSMCs) in resistance arteries and arterioles express a diverse array of voltage-gated K(+) (KV ) channels with members of the KV 1, KV 2 and KV 7 families being particularly important. Members of the KV channel family: 1.) are highly expressed in VSMCs; 2.) are active at the resting membrane potential of VSMCs in vivo (-45 to -30 mV); 3.) contribute to the negative feedback regulation of VSMC membrane potential and myogenic tone; 4.) are activated by cAMP-related vasodilators, hydrogen sulfide and hydrogen peroxide; 5...
October 6, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
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