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Spinal manipulation

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https://www.readbyqxmd.com/read/28324697/adverse-events-in-a-chiropractic-spinal-manipulative-therapy-single-blinded-placebo-randomized-controlled-trial-for-migraineurs
#1
Aleksander Chaibi, Jūratė Šaltytė Benth, Peter J Tuchin, Michael Bjørn Russell
BACKGROUND: Unlike pharmacological randomized controlled trials (RCTs), manual-therapy RCTs do not always report adverse events (AEs). The few manual-therapy RCTs that provide information on AEs are frequently without details, such as the type and-, severity of the AE and reason for withdrawal. OBJECTIVE: To prospectively report all AEs in a chiropractic spinal manipulative therapy (CSMT) RCT. DESIGN: A prospective 3-armed, single-blinded, placebo, RCT...
March 14, 2017: Musculoskelet Sci Pract
https://www.readbyqxmd.com/read/28315275/sigma-1-receptor-in-motoneuron-disease
#2
Renzo Mancuso, Xavier Navarro
Amyotrophic Lateral Sclerosis (ALS ) is a neurodegenerative disease affecting spinal cord and brain motoneurons , leading to paralysis and early death. Multiple etiopathogenic mechanisms appear to contribute in the development of ALS , including glutamate excitotoxicity, oxidative stress , protein misfolding, mitochondrial defects, impaired axonal transport, inflammation and glial cell alterations. The Sigma-1 receptor is highly expressed in motoneurons of the spinal cord, particularly enriched in the endoplasmic reticulum (ER) at postsynaptic cisternae of cholinergic C-terminals...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28302309/best-practices-for-chiropractic-care-for-older-adults-a-systematic-review-and-consensus-update
#3
Cheryl Hawk, Michael J Schneider, Mitchell Haas, Paul Katz, Paul Dougherty, Brian Gleberzon, Lisa Z Killinger, John Weeks
OBJECTIVE: The purpose of this study was to update evidence-based recommendations on the best practices for chiropractic care of older adults. METHODS: The project consisted of a systematic literature review and a consensus process. The following were searched from October 2009 through January 2016: MEDLINE, Index to Chiropractic Literature, CINAHL (Cumulative Index to Nursing and Allied Health Literature), AMED (Allied and Complementary Medicine Database), Alt HealthWatch, Cochrane Database of Systematic Reviews, and Cochrane Registry of Controlled Trials...
March 14, 2017: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/28292267/assignment-of-adverse-event-indexing-terms-in-randomized-clinical-trials-involving-spinal-manipulative-therapy-an-audit-of-records-in-medline-and-embase-databases
#4
Lindsay M Gorrell, Roger M Engel, Reidar P Lystad, Benjamin T Brown
BACKGROUND: Reporting of adverse events in randomized clinical trials (RCTs) is encouraged by the authors of The Consolidated Standards of Reporting Trials (CONSORT) statement. With robust methodological design and adequate reporting, RCTs have the potential to provide useful evidence on the incidence of adverse events associated with spinal manipulative therapy (SMT). During a previous investigation, it became apparent that comprehensive search strategies combining text words with indexing terms was not sufficiently sensitive for retrieving records that were known to contain reports on adverse events...
March 14, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28288900/the-mechanism-of-back-pain-relief-by-spinal-manipulation-relies-on-decreased-temporal-summation-of-pain
#5
Christopher Randoll, Vincent Gagnon-Normandin, Jessica Tessier, Suzie Bois, Nabi Rustamov, Julie O'Shaughnessy, Martin Descarreaux, Mathieu Piché
The aim of the present study was to determine whether thoracic spinal manipulation (SM) decreases temporal summation of back pain. The study comprised 2 controlled experiments including 16 and 15 healthy participants, respectively. Each study included 6 sessions during which painful or non-painful electrical stimulations were delivered in three conditions: 1) control 2) light mechanical stimulus (MS) or 3) SM. Electrical stimulation was applied on the thoracic spine (T4), in the area where SM and MS were performed...
March 10, 2017: Neuroscience
https://www.readbyqxmd.com/read/28274487/manipulation-peak-forces-across-spinal-regions-for-children-using-mannequin-simulators
#6
John J Triano, Steven Lester, David Starmer, Elise G Hewitt
OBJECTIVE: The purpose of this work was to create an exploratory database of manipulation treatment force variability as a function of the intent of an experienced clinician sub-specializing in the care of children to match treatment to childhood category. Data of this type are necessary for realistic planning of dose-response and safety studies on therapeutic benefit. METHODS: The project evaluated the transmitted peak forces of procedures applied to mannequins of different stature for younger and older children...
March 5, 2017: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/28268027/a-feasibility-study-to-assess-vibration-and-sound-from-zygapophyseal-joints-during-motion-before-and-after-spinal-manipulation
#7
Gregory D Cramer, Matthew Budavich, Preetam Bora, Kim Ross
OBJECTIVE: This feasibility study used novel accelerometry (vibration) and microphone (sound) methods to assess crepitus originating from the lumbar spine before and after side-posture spinal manipulative therapy (SMT). METHODS: This study included 5 healthy and 5 low back pain (LBP) participants. Nine accelerometers and 1 specialized directional microphone were applied to the lumbar region, allowing assessment of crepitus. Each participant underwent full lumbar ranges of motion (ROM), bilateral lumbar SMT, and repeated full ROM...
March 3, 2017: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/28266959/morphometric-analysis-of-the-retroperitoneal-vessels-with-respect-to-lateral-access-surgery-in-adult-scoliosis
#8
Heeren S Makanji, Hai Le, Kirkham B Wood, Louis G Jenis, Thomas D Cha
STUDY DESIGN: Cross-sectional study reviewing 62 magnetic resonance imaging or computed tomography scans from consecutive adult patients with scoliotic spinal deformity in the thoracolumbar spine. OBJECTIVE: To investigate the variation in anatomic position of retroperitoneal vessels in relationship to curve direction, location, magnitude, and axial rotation of curves in adult scoliosis. SUMMARY OF BACKGROUND DATA: The minimally invasive lateral approach to the thoracolumbar spine avoids manipulation of abdominal and retroperitoneal structures and decreases risk of injury to paraspinal musculature...
March 6, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28259496/integrative-acupuncture-and-spinal-manipulative-therapy-versus-either-alone-for-low-back-pain-a-randomized-controlled-trial-feasibility-study
#9
Anupama Kizhakkeveettil, Kevin A Rose, Gena E Kadar, Eric L Hurwitz
OBJECTIVES: The objective of this study was to assess the feasibility of conducting a large-scale randomized controlled trial (RCT) examining whether an integrative care model combining spinal manipulative therapy (SMT) and acupuncture can lead to better outcomes for low back pain (LBP) than either therapy alone. METHODS: This study was conducted at a complementary and alternative medicine university health center. Participants with acute or chronic LBP were randomized to (1) acupuncture, (2) SMT, or (3) integrative acupuncture and SMT groups...
March 1, 2017: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/28243811/transjugular-tubercle-preaccessory-approach-for-ventrocaudally-located-pica-aneurysm
#10
Tetsuyoshi Horiuchi, Alhusain Nagm, Takatoshi Hasegawa, Kazuhiro Hongo
BACKGROUND: Posterior inferior cerebellar artery (PICA) aneurysms are often located in the ventral craniocervical junction. Such deep-seated aneurysms are usually treated with coil embolization. However, recurred and/or very small PICA aneurysms are hardly treated with an endovascular approach. METHOD: We present a modification of the transcondylar fossa approach with intradural and extradural removal of the jugular tubercle. An adequate preaccessory surgical corridor was created with this novel technique...
February 27, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28229085/folate-receptor-alpha-is-more-than-just-a-folate-transporter
#11
Vineet Mohanty, M Rizwan Siddiqui, Tadanori Tomita, Chandra Shekhar Mayanil
Until recently folate receptor alpha (FRα) has only been considered as a folate transporter. However, a novel role of FRα as a transcription factor was reported by our lab. More recently our lab showed a novel pleiotropic role of FRα: (a) direct transcriptional activation of Oct4, Sox2, and Klf4 genes; and (b) repression of biogenesis of miRNAs that target these genes or their effector molecules. These observations beg a question: "Can a simple molecule such as folate be used to manipulate the production and/or differentiation of endogenous neural stem cells (NSCs), which may hold promise for future therapies?" Conditions such as spinal cord injury, motor neuron diseases, Alzheimer's disease and multiple sclerosis may benefit from increasing stem cell pool and promoting specific pathways of differentiation...
2017: Neurogenesis (Austin, Tex.)
https://www.readbyqxmd.com/read/28228701/chiropractic-management-of-a-patient-with-thoracic-pain-and-a-stable-thoracic-aortic-aneurysm-a-case-report
#12
Shawn M Neff, Casey S Okamoto
OBJECTIVE: The purpose of this case report was to describe chiropractic management of thoracic pain in a patient with a stable thoracic aortic aneurysm. CLINICAL FEATURES: An 89-year-old man presented with axial mid- and upper back pain localized predominantly at the T8 and T1 spinal segmental levels. A review of available imaging revealed a stable aneurysmal dilatation of the ascending aorta, which measured 4.3 cm. INTERVENTION AND OUTCOME: Because the thoracic pain was musculoskeletal in nature and the thoracic aortic aneurysm was stable, mechanical manipulation was provided using the Impulse adjusting instrument...
March 2017: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/28228696/combining-spinal-manipulation-with-standard-counseling-for-tobacco-cessation-results-of-a-feasibility-randomized-clinical-trial
#13
Kevin A Rose, Anupama Kizhakkeveettil, Gena E Kadar, Mark Losack
OBJECTIVE: The purpose of this study was to test the feasibility of a randomized clinical trial on the effectiveness of combining spinal manipulation (SM) with standard tobacco cessation counseling. METHODS: A randomized clinical trial was conducted. Participants in the intervention group received 2 months of counseling plus SM delivered by doctors of chiropractic, whereas control group participants received counseling alone. Primary outcome measures were smoking decreases and 7-day smoking abstinence as measured by a tobacco diary and urinary cotinine...
March 2017: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/28228050/is-neck-massage-safe-a-rare-case-of-tetraplegia-and-spinal-shock-after-neck-manipulation
#14
Tan Han Ling, Amir Fariz Bin Zakaria, Ahmad Tajuddin Bin Abdullah
Neck manipulation is associated with spinal cord injury. However, occurrence of such cases is infrequent. This article presents a 33-year-old gentleman who sustained acute tetraplegia after neck manipulation. The aim of this case report is to create awareness that vigorous neck manipulation could cause injury to the spinal cord.
January 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28225868/n-acetylcysteine-downregulates-phosphorylated-p-38-expression-but-does-not-reverse-the-increased-superoxide-anion-levels-in-the-spinal-cord-of-rats-with-neuropathic-pain
#15
A Horst, J A de Souza, M C Q Santos, A P K Riffel, C Kolberg, M F M Ribeiro, L S de Fraga, W A Partata
We determined the effect of N-acetylcysteine (NAC) on the expression of the phosphorylated p38 (p-p38) protein and superoxide anion generation (SAG), two important players in the processing of neuropathic pain, in the lumbosacral spinal cord of rats with chronic constriction injury (CCI)-induced neuropathic pain. The sciatic functional index (SFI) was also measured to assess the functional recovery post-nerve lesion. Thirty-six male Wistar rats were divided equally into the following groups: Naive (rats did not undergo surgical manipulation); Sham (rats in which all surgical procedures involved in CCI were used except the ligature), and CCI (rats in which four ligatures were tied loosely around the right common sciatic nerve), which received 2, 4, or 8 intraperitoneal injections of NAC (150 mg·kg-1·day-1) or saline beginning 4 h after CCI...
February 16, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28215058/effect-of-cervical-versus-thoracic-spinal-manipulation-on-peripheral-neural-features-and-grip-strength-in-subjects-with-chronic-mechanical-neck-pain-a-randomized-controlled-trial
#16
Francisco Bautista-Aguirre, Ángel Oliva-Pascual-Vaca, Alberto M Heredia-Rizo, Juan J Boscá-Gandía, François Ricard, Cleofás Rodriguez-Blanco
BACKGROUND: Cervical and thoracic spinal manipulative therapy has shown positive impact for relief of pain and improve function in non-specific mechanical neck pain. Several attempts have been made to compare their effectiveness although previous studies lacked a control group, assessed acute neck pain or combined thrust and nonthrust techniques. AIM: To compare the immediate effects of cervical and thoracic spinal thrust manipulations on mechanosensitivity of upper limb nerve trunks and grip strength in patients with chronic non-specific mechanical neck pain...
February 17, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28202041/the-microtubule-plus-end-tracking-protein-tacc3-promotes-persistent-axon-outgrowth-and-mediates-responses-to-axon-guidance-signals-during-development
#17
Burcu Erdogan, Garrett M Cammarata, Eric J Lee, Benjamin C Pratt, Andrew F Francl, Erin L Rutherford, Laura Anne Lowery
BACKGROUND: Formation of precise neuronal connections requires proper axon guidance. Microtubules (MTs) of the growth cone provide a critical driving force during navigation of the growing ends of axons. Pioneer MTs and their plus-end tracking proteins (+TIPs) are thought to play integrative roles during this navigation. TACC3 is a + TIP that we have previously implicated in regulating MT dynamics within axons. However, the role of TACC3 in axon guidance has not been previously explored...
February 15, 2017: Neural Development
https://www.readbyqxmd.com/read/28196632/procedure-selection-and-patient-positioning-influence-spine-kinematics-during-high-velocity-low-amplitude-spinal-manipulation-applied-to-the-low-back
#18
Spencer Bell, Kevin D'Angelo, Gregory N Kawchuk, John J Triano, Samuel J Howarth
OBJECTIVES: This investigation compared indirect 3-dimensional angular kinematics (position, velocity, and acceleration) of the lumbar spine for 2 different high-velocity, low-amplitude (HVLA) spinal manipulation procedures (lumbar spinous pull or push), and altered initial patient lower limb posture. METHODS: Twenty-four participants underwent 6 HVLA procedures directed toward the presumed L4 vertebra, reflecting each combination of 2 variants of a spinal manipulation application technique (spinous pull and push) and 3 initial hip flexion angles (0°, 45°, and 90°) applied using a right lateral recumbent patient position...
February 10, 2017: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/28196631/effects-of-12-weeks-of-chiropractic-care-on-central-integration-of-dual-somatosensory-input-in-chronic-pain-patients-a-preliminary-study
#19
Heidi Haavik, Imran Khan Niazi, Kelly Holt, Bernadette Murphy
OBJECTIVE: The purpose of this preliminary study was to assess whether the dual somatosensory evoked potential (SEP) technique is sensitive enough to measure changes in cortical intrinsic inhibitory interactions in patients with chronic neck or upper extremity pain and, if so, whether changes are associated with changes in pain scores. METHODS: The dual peripheral nerve stimulation SEP ratio technique was used for 6 subjects with a history of chronic neck or upper limb pain...
February 10, 2017: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/28193058/development-of-a-biocompatible-in-tube-solid-phase-microextraction-device-a-sensitive-approach-for-direct-analysis-of-single-drops-of-complex-matrixes
#20
Hamed Piri-Moghadam, Sofia Lendor, Janusz Pawliszyn
The aim of the current study is to develop a sensitive solid-phase microextraction (SPME) device for direct and rapid analysis of untreated complex matrixes (i.e., single drop of the samples, V ≤ 2 μL). A thin layer of a biocompatible nanostructured polypyrrole (PPy) was electrochemically deposited inside a medical grade spinal needle, minimizing the matrix effect. Microsampling was facilitated by loading the sample inside the in-tube SPME device (withdraw of sample via plunger), where extraction was performed under static conditions...
December 20, 2016: Analytical Chemistry
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