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Spinal manipulation

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https://www.readbyqxmd.com/read/29335358/sox2-is-essential-for-oligodendroglial-proliferation-and-differentiation-during-postnatal-brain-myelination-and-cns-remyelination
#1
Sheng Zhang, Xiaoqing Zhu, Xuehong Gui, Christopher Croteau, Lanying Song, Jie Xu, Aijun Wang, Peter Bannerman, Fuzheng Guo
In the central nervous system (CNS), myelination and remyelination depend on the successful progression and maturation of oligodendroglial lineage cells including proliferation and differentiation of oligodendroglial progenitor cells (OPCs). Previous studies have reported that Sox2 transiently regulates oligodendrocyte (OL) differentiation in the embryonic and perinatal spinal cord and appears dispensable for myelination in the postnatal spinal cord. However, the role of Sox2 in OL development in the brain has yet to be defined...
January 15, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29332747/effects-of-spinal-manipulation-and-myofascial-techniques-on-heart-rate-variability-a-systematic-review
#2
Bruno Luis Amoroso Borges, Gustavo Luiz Bortolazzo, Hugo Pasin Neto
BACKGROUND: The analysis of heart rate variability is important to the investigation of stimuli from the autonomic nervous system. Osteopathy is a form of treatment that can influence this system in healthy individuals as well as those with a disorder or disease. OBJECTIVES: The aim of the present study was to perform a systematic review of the literature regarding the effect of spinal manipulation and myofascial techniques on heart rate variability. METHODS: Searches were performed of the Pubmed, Scielo, Lilacs, PEDro, Ibesco, Cochrane and Scopus databases for relevant studies...
January 2018: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29327170/the-effects-of-a-single-session-of-spinal-manipulation-on-strength-and-cortical-drive-in-athletes
#3
Thomas Lykke Christiansen, Imran Khan Niazi, Kelly Holt, Rasmus Wiberg Nedergaard, Jens Duehr, Kathryn Allen, Paul Marshall, Kemal S Türker, Jan Hartvigsen, Heidi Haavik
PURPOSE: The primary purpose of this study was to investigate whether a single session of spinal manipulation (SM) increases strength and cortical drive in the lower limb (soleus muscle) of elite Taekwondo athletes. METHODS: Soleus-evoked V-waves, H-reflex and maximum voluntary contraction (MVC) of the plantar flexors were recorded from 11 elite Taekwondo athletes using a randomized controlled crossover design. Interventions were either SM or passive movement control...
January 11, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29310887/erratum-to-changes-in-lower-limb-strength-and-function-following-lumbar-spinal-mobilization-j-manipulative-physiol-ther-2017-40-8-587-596
#4
Tsoi Sze Yuen, Joseph Ng, Pui Yu Lam, Mei Yan Lau, Wai Lam Siu, Ka Man Yu, Chi Ngai Lo
No abstract text is available yet for this article.
January 6, 2018: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/29308669/an-open-label-study-of-a-novel-immunosuppression-intervention-for-the-treatment-of-amyotrophic-lateral-sclerosis
#5
Christina N Fournier, David Schoenfeld, James D Berry, Merit E Cudkowicz, James Chan, Colin Quinn, Robert H Brown, Johnny S Salameh, Malu G Tansey, David R Beers, Stanley H Appel, Jonathan D Glass
Neuroinflammation is increasingly tied to disease progression in amyotrophic lateral sclerosis (ALS). Participants in the first-in-human trial of intra-spinal allogeneic stem cell therapy for ALS received immunosuppression, and one participant saw dramatic improvement across multiple outcome measures. The primary objective of this study (NCT01884571) was to assess the rate of clinical response to the same immunosuppressive regimen using basiliximab, tacrolimus, mycophenolate, and prednisone in people with ALS...
January 8, 2018: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/29307457/integration-of-doctors-of-chiropractic-into-private-sector-health-care-facilities-in-the-united-states-a-descriptive-survey
#6
Stacie A Salsbury, Christine M Goertz, Elissa J Twist, Anthony J Lisi
OBJECTIVE: The purpose of this study was to describe the demographic, facility, and practice characteristics of doctors of chiropractic (DCs) working in private sector health care settings in the United States. METHODS: We conducted an online, cross-sectional survey using a purposive sample of DCs (n = 50) working in integrated health care facilities. The 36-item survey collected demographic, facility, chiropractic, and interdisciplinary practice characteristics, which were analyzed with descriptive statistics...
January 4, 2018: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/29296053/nonfatal-pulmonary-embolism-associated-with-the-use-of-compression-stockings-in-the-lithotomy-position-after-spinal-anesthesia
#7
I-Wen Chen, Cheuk-Kwan Sun, Jen-Yin Chen, Chien-Ming Lin, Kuo-Chuan Hung
A 73-year-old male (height, 156 cm; body weight, 51 kg), without a history of cardiovascular disease or thromboembolic events, was scheduled for transurethral resection of the prostate under spinal anesthesia. Spinal anesthesia was administered with hyperbaric bupivacaine, resulting in an upper anesthetic level of T6. Before surgery, compression stockings were applied to both lower limbs, and the patient was placed in the lithotomy position. Approximately 15 min later, he complained of intolerable chest tightness, followed by tachycardia (heart rate, 110 beats/min) and desaturation (oxygen saturation [SaO2], 90%)...
October 2017: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
https://www.readbyqxmd.com/read/29282251/%C3%AE-%C3%AE-t-cells-provide-the-early-source-of-ifn-%C3%AE-to-aggravate-lesions-in-spinal-cord-injury
#8
Guodong Sun, Shuxian Yang, Guangchao Cao, Qianghua Wang, Jianlei Hao, Qiong Wen, Zhizhong Li, Kwok-Fai So, Zonghua Liu, Sufang Zhou, Yongxiang Zhao, Hengwen Yang, Libing Zhou, Zhinan Yin
Immune responses and neuroinflammation are critically involved in spinal cord injury (SCI). γδ T cells, a small subset of T cells, regulate the inflammation process in many diseases, yet their function in SCI is still poorly understood. In this paper, we demonstrate that mice deficient in γδ T cells (TCRδ-/- ) showed improved functional recovery after SCI. γδ T cells are detected at the lesion sites within 24 hours after injury and are predominantly of the Vγ4 subtype and express the inflammatory cytokine IFN-γ...
December 27, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29276462/chiropractic-care-in-the-management-of-inactive-ankylosing-spondylitis-a-case-series
#9
Stacey M Cornelson, David Beavers, Allison Harvey, William Hogarth, Norman W Kettner
Objective: This report describes chiropractic management for 3 cases of inactive ankylosing spondylitis (AS). Clinical Features: A 25-year-old woman presented with chronic, mechanical neck pain and stiffness that was ultimately diagnosed as AS. A 23-year-old man presented with chronic low back and left hip pain that was diagnosed as AS. A 31-year-old man with low back pain presented with a known diagnosis of AS. Physical examination in 2 cases failed to identify systemic findings associated with AS...
December 2017: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/29258553/prenatal-alcohol-exposure-is-a-risk-factor-for-adult-neuropathic-pain-via-aberrant-neuroimmune-function
#10
Joshua J Sanchez, Shahani Noor, Suzy Davies, Daniel Savage, Erin D Milligan
BACKGROUND: Clinical studies show that prenatal alcohol exposure (PAE) results in effects that persist into adulthood. Experimental animal models of moderate PAE demonstrate that young adults with PAE display potentiated sensitivity to light touch, clinically termed allodynia, following sciatic nerve chronic constriction injury (CCI) that coincides with heightened spinal glial, spinal macrophage, and peripheral immune responses. However, basal touch sensitivity and corresponding glial and leukocyte activation are unaltered...
December 19, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29246434/endovascular-repair-of-acute-thoraco-abdominal-aortic-aneurysms
#11
Chiara Mascoli, Massimo Vezzosi, Andreas Koutsoumpelis, Mauro Iafrancesco, Aaron Ranasinghe, Paul Clift, Jorge Mascaro, Martin Claridge, Donald J Adam
OBJECTIVES: The outcome of endovascular repair (EVAR) for acute TAAA is reported and the applicability of the t-Branch off the shelf (OTS) device is determined. METHODS: Interrogation of a prospectively maintained database identified all patients who underwent EVAR for acute TAAA between September 2012 (when the first non-elective t-Branch case was performed) and November 2015. Early and medium-term outcomes were analysed. Survival and re-intervention-free survival were calculated by Kaplan-Meier analysis...
December 12, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29239336/neural-progenitor-cells-but-not-astrocytes-respond-distally-to-thoracic-spinal-cord-injury-in-rat-models
#12
Tara Nguyen, Yilin Mao, Theresa Sutherland, Catherine Anne Gorrie
Traumatic spinal cord injury (SCI) is a detrimental condition that causes loss of sensory and motor function in an individual. Many complex secondary injury cascades occur after SCI and they offer great potential for therapeutic targeting. In this study, we investigated the response of endogenous neural progenitor cells, astrocytes, and microglia to a localized thoracic SCI throughout the neuroaxis. Twenty-five adult female Sprague-Dawley rats underwent mild-contusion thoracic SCI (n = 9), sham surgery (n = 8), or no surgery (n = 8)...
November 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29234493/what-are-the-risks-of-manual-treatment-of-the-spine-a-scoping-review-for-clinicians
#13
REVIEW
Gabrielle Swait, Rob Finch
Background: Communicating to patients the risks of manual treatment to the spine is an important, but challenging element of informed consent. This scoping review aimed to characterise and summarise the available literature on risks and to describe implications for clinical practice and research. Method: A methodological framework for scoping reviews was followed. Systematic searches were conducted during June 2017. The quantity, nature and sources of literature were described...
2017: Chiropractic & Manual Therapies
https://www.readbyqxmd.com/read/29233995/adeno-associated-virus-serotype-rh10-is-a-useful-gene-transfer-vector-for-sensory-nerves-that-innervate-bone-in-immunodeficient-mice
#14
Sun H Park, Matthew R Eber, Shunsuke Tsuzuki, Mary E Booker, Aaron G Sunil, D Brooke Widner, Renee A Parker, Christopher M Peters, Yusuke Shiozawa
Adeno-associated virus (AAV) is frequently used to manipulate gene expression in the sensory nervous system for the study of pain mechanisms. Although some serotypes of AAV are known to have nerve tropism, whether AAV can distribute to sensory nerves that innervate the bone or skeletal tissue has not been shown. This information is crucial, since bone pain, including cancer-induced bone pain, is an area of high importance in pain biology. In this study, we found that AAVrh10 transduces neurons in the spinal cord and dorsal root ganglia of immunodeficient mice with higher efficacy than AAV2, 5, 6, 8, and 9 when injected intrathecally...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29225897/-bottom-hung-window-trauma-in-cats-neurological-evaluation-and-outcome-in-71-cats-with-bilateral-hindlimb-injury
#15
Gabriele M Gradner, Lina Dogman-Rauberger, Gilles Dupré
Objectives: Influence of neurological status on the mortality rate of paraparetic/paralysed cats presenting after entrapment in a bottom-hung window was evaluated. It was hypothesised that (1) loss of deep pain sensation at admission would not be a negative prognostic factor for regaining motor function and that (2) mortality rate would be influenced by the severity of neurological grade upon admission. Methods: Clinical and pathological data of affected cats that presented at our institution between 2001 and 2012 for this specific trauma were collected retrospectively: breed, age, sex, last contact with owner (<3 hours and >3 hours), whether the cat was suffering from monoparesis or paraparesis/paraplegia, duration of hospitalisation, rectal temperature, surface temperature of the skin of the hindlimbs, femoral pulse and tone of the pelvic musculature...
2017: Veterinary Record Open
https://www.readbyqxmd.com/read/29224725/ror%C3%AE-spinal-interneurons-gate-sensory-transmission-during-locomotion-to-secure-a-fluid-walking-gait
#16
Stephanie C Koch, Marta Garcia Del Barrio, Antoine Dalet, Graziana Gatto, Thomas Günther, Jingming Zhang, Barbara Seidler, Dieter Saur, Roland Schüle, Martyn Goulding
Animals depend on sensory feedback from mechanosensory afferents for the dynamic control of movement. This sensory feedback needs to be selectively modulated in a task- and context-dependent manner. Here, we show that inhibitory interneurons (INs) expressing the RORβ orphan nuclear receptor gate sensory feedback to the spinal motor system during walking and are required for the production of a fluid locomotor rhythm. Genetic manipulations that abrogate inhibitory RORβ IN function result in an ataxic gait characterized by exaggerated flexion movements and marked alterations to the step cycle...
December 5, 2017: Neuron
https://www.readbyqxmd.com/read/29214015/effect-of-spinal-manipulative-treatment-on-cardiovascular-autonomic-control-in-patients-with-acute-low-back-pain
#17
Mohamed Younes, Karine Nowakowski, Benoit Didier-Laurent, Michel Gombert, François Cottin
Background: This study aimed to quantify the effect of spinal manipulative treatment (SMT) from an analysis of baroreflex, systolic blood pressure and heart rate variability (HRV) on patients with acute back pain. It was hypothesized that SMT would increase the parasympathetic cardiovascular autonomic control. Methods: Twenty-two patients with acute back pain were randomly divided into two groups: one receiving sham treatment (Sham) and the other receiving SMT. Recordings were completed during the first day and the seventh day, immediately before and after treatment on both days...
2017: Chiropractic & Manual Therapies
https://www.readbyqxmd.com/read/29213073/reversible-silencing-of-lumbar-spinal-interneurons-unmasks-a-task-specific-network-for-securing-hindlimb-alternation
#18
Amanda M Pocratsky, Darlene A Burke, Johnny R Morehouse, Jason E Beare, Amberly S Riegler, Pantelis Tsoulfas, Gregory J R States, Scott R Whittemore, David S K Magnuson
Neural circuitry in the lumbar spinal cord governs two principal features of locomotion, rhythm and pattern, which reflect intra- and interlimb movement. These features are functionally organized into a hierarchy that precisely controls stepping in a stereotypic, speed-dependent fashion. Here, we show that a specific component of the locomotor pattern can be independently manipulated. Silencing spinal L2 interneurons that project to L5 selectively disrupts hindlimb alternation allowing a continuum of walking to hopping to emerge from the otherwise intact network...
December 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/29207995/physicians-using-spinal-manipulative-treatment-in-the-netherlands-a-description-of-their-characteristics-and-their-patients
#19
Wouter Schuller, Raymond W J G Ostelo, Daphne C Rohrich, Adri T Apeldoorn, Henrica C W de Vet
BACKGROUND: Various health care professionals apply Spinal Manipulative Treatment (SMT) in daily practice. While the characteristics of chiropractors and manual therapists and the characteristics of their patient populations are well described, there is little research about physicians who use SMT techniques. A distinct group of physicians in The Netherlands has been trained in musculoskeletal (MSK) medicine, which includes the use of SMT. Our objective was to describe the characteristics of these physicians and their patient population...
December 6, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29201346/the-chiropractic-profession-a-scoping-review-of-utilization-rates-reasons-for-seeking-care-patient-profiles-and-care-provided
#20
REVIEW
Peter J H Beliveau, Jessica J Wong, Deborah A Sutton, Nir Ben Simon, André E Bussières, Silvano A Mior, Simon D French
Background: Previous research has investigated utilization rates, who sees chiropractors, for what reasons, and the type of care that chiropractors provide. However, these studies have not been comprehensively synthesized. We aimed to give a global overview by summarizing the current literature on the utilization of chiropractic services, reasons for seeking care, patient profiles, and assessment and treatment provided. Methods: Systematic searches were conducted in MEDLINE, CINAHL, and Index to Chiropractic Literature using keywords and subject headings (MeSH or ChiroSH terms) from database inception to January 2016...
2017: Chiropractic & Manual Therapies
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