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Spinal manipulation

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https://www.readbyqxmd.com/read/29769391/infrared-laser-mediated-gene-induction-at-the-single-cell-level-in-the-regenerating-tail-of-xenopus-laevis-tadpoles
#1
Riho Hasugata, Shinichi Hayashi, Aiko Kawasumi-Kita, Joe Sakamoto, Yasuhiro Kamei, Hitoshi Yokoyama
We describe a precise and reproducible gene-induction method in the amphibian, Xenopus laevis Tetrapod amphibians are excellent models for studying the mechanisms of three-dimensional organ regeneration because they have an exceptionally high regenerative ability. However, spatial and temporal manipulation of gene expression has been difficult in amphibians, hindering studies on the molecular mechanisms of organ regeneration. Recently, however, development of a Xenopus transgenic system with a heat-shock-inducible gene has enabled the manipulation of specific genes...
May 16, 2018: Cold Spring Harbor Protocols
https://www.readbyqxmd.com/read/29767395/behavioral-therapy-approaches-for-the-management-of-low-back-pain-an-up-to-date-systematic-review
#2
REVIEW
Kristallia Vitoula, Annalena Venneri, Giustino Varrassi, Antonella Paladini, Panagiota Sykioti, Joy Adewusi, Panagiotis Zis
Low back pain is one of the most common causes for seeking medical treatment and it is estimated that one in two people will experience low back pain at some point during their lifetimes. Management of low back pain includes pharmacological and non-pharmacological approaches. Non-pharmaceutical treatments include interventions such as acupuncture, spinal manipulation, and psychotherapy. The latter is especially important as patients who suffer from low back pain often have impaired quality of life and also suffer from depression...
May 16, 2018: Pain and Therapy
https://www.readbyqxmd.com/read/29765191/alleviation-of-posttraumatic-dizziness-by-restoration-of-the-cervical-lordosis-a-cbp-%C3%A2-case-study-with-a-one-year-follow-up
#3
Miles O Fortner, Paul A Oakley, Deed E Harrison
[Purpose] To present the successful treatment of posttraumatic dizziness and neck pains that were initiated in a patient following a whiplash event. [Subject and Methods] A 46 year old male suffered a whiplash event that initiated neck pain and dizziness symptoms. The patient had many positive orthopedic findings and demonstrated a forward head posture and cervical hypolordosis. The patient was treated by Chiropractic BioPhysics® technique including cervical extension traction, extension exercises and spinal manipulative therapy initially three times a week for 16-weeks, and once a month thereafter...
May 2018: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29760878/chiropractic-treatment-including-instrument-assisted-manipulation-for-non-specific-dizziness-and-neck-pain-in-community-dwelling-older-people-a-feasibility-randomised-sham-controlled-trial
#4
Julie C Kendall, Simon D French, Jan Hartvigsen, Michael F Azari
Background: Dizziness in older people is a risk factor for falls. Neck pain is associated with dizziness and responds favourably to neck manipulation. However, it is unknown if chiropractic intervention including instrument-assisted manipulation of the neck in older people with neck pain can also improve dizziness. Methods: This parallel two-arm pilot trial was conducted in Melbourne, Australia over nine months (October 2015 to June 2016). Participants aged 65-85 years, with self-reported chronic neck pain and dizziness, were recruited from the general public through advertisements in local community newspapers and via Facebook...
2018: Chiropractic & Manual Therapies
https://www.readbyqxmd.com/read/29760552/patients-receiving-chiropractic-care-in-a-neurorehabilitation-hospital-a-descriptive-study
#5
Robert D Vining, Stacie A Salsbury, W Carl Cooley, Donna Gosselin, Lance Corber, Christine M Goertz
Objectives: Individuals rehabilitating from complex neurological injury require a multidisciplinary approach, which typically does not include chiropractic care. This study describes inpatients receiving multidisciplinary rehabilitation including chiropractic care for brain injury, spinal cord injury (SCI), stroke, and other complex neurological conditions. Design: Chiropractic services were integrated into Crotched Mountain Specialty Hospital (CMSH) through this project...
2018: Journal of Multidisciplinary Healthcare
https://www.readbyqxmd.com/read/29758384/disruption-of-shp1-nmda-receptor-signaling-in-spinal-cord-dorsal-horn-alleviated-inflammatory-pain
#6
Li Yang, Hu-Hu Bai, Zi-Yang Zhang, Jiang-Ping Liu, Zhan-Wei Suo, Xian Yang, Xiao-Dong Hu
Src-homology 2 domain-containing protein tyrosine phosphatase-1 (SHP1) is one of the non-receptor-like phosphatases that are highly enriched in hematopoietic cells. Although accumulating evidence has implicated the protein tyrosine phosphatases in the regulation of nociceptive transmission and plasticity, it is largely unknown whether SHP1 was expressed in pain-related spinal cord dorsal horn and engaged in the synaptic modification of nociceptive signals. Here we found that SHP1 was present in spinal neurons of rats and functionally coupled to GluN2A subunit-containing N-methyl-d-aspartate subtype of glutamate receptors, one of the key players in central sensitization of nociceptive behaviors...
April 30, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29758356/the-influence-of-placebo-analgesia-manipulations-on-pain-report-the-nociceptive-flexion-reflex-and-autonomic-responses-to-pain
#7
Jamie L Rhudy, Yvette M Güereca, Bethany L Kuhn, Shreela Palit, Magne Arve Flaten
Expectations for pain relief and experience/conditioning are psychological factors that contribute to placebo analgesia, yet few studies have studied the physiological mechanisms underlying their effects. This study randomized 133 participants to 4 groups: an expectation only (E-only) group, a conditioning only (C-only) group, an expectation plus conditioning (E+C) group, and a natural history (NH) control group. Painful electric stimulations were delivered before and after an inert cream was applied to the site of stimulation...
May 11, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29753844/contextualizing-action-observation-in-the-predictive-brain-causal-contributions-of-prefrontal-and-middle-temporal-areas
#8
Lucia Amoruso, Alessandra Finisguerra, Cosimo Urgesi
Context facilitates the recognition of forthcoming actions by pointing to which intention is likely to drive them. This intention is thought to be estimated in a ventral pathway linking MTG with frontal regions and to further impact on the implementation of sensory predictions within the action observation network (AON). Additionally, when conflicting intentions are estimated from context, the DLPFC may bias action selection. However, direct evidence for the contribution of these areas to context-embedded action representations in the AON is still lacking...
May 10, 2018: NeuroImage
https://www.readbyqxmd.com/read/29752242/automated-fes-for-upper-limb-rehabilitation-following-stroke-and-spinal-cord-injury
#9
Edmund F Hodkin, Yuming Lei, Jonathan Humby, Isabel S Glover, Supriyo Choudhury, Hrishikesh Kumar, Monica A Perez, Helen Rodgers, Andrew Jackson
Neurorehabilitation aims to induce beneficial neural plasticity in order to restore function following injury to the nervous system. There is an increasing evidence that appropriately timed functional electrical stimulation (FES) can promote associative plasticity, but the dosage is critical for lasting functional benefits. Here, we present a novel approach to closed-loop control of muscle stimulation for the rehabilitation of reach-to-grasp movements following stroke and spinal cord injury (SCI). We developed a simple, low-cost device to deliver assistive stimulation contingent on users' self-initiated movements...
May 2018: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/29751028/role-of-c1-neurons-in-anti-inflammatory-reflex-mediation-between-afferents-and-efferents
#10
REVIEW
Chikara Abe, Tsuyoshi Inoue
Neuroimmune communication, the connection between the autonomic regulatory pathway and immune cells, has been implicated in the regulation of immune function and inflammation. The role of afferents (vagal afferent and somatic sensory nerves) and efferents (autonomic nervous and hypothalamic-pituitary-adrenal systems) in the inflammatory reflex has been well studied; however, the central pathway remains unknown. C1 neurons include both catecholaminergic and glutamatergic neurons, which are located in the rostral ventrolateral medulla...
May 8, 2018: Neuroscience Research
https://www.readbyqxmd.com/read/29750754/the-barrow-biomimetic-spine-fluoroscopic-analysis-of-a-synthetic-spine-model-made-of-variable-3d-printed-materials-and-print-parameters
#11
Michael A Bohl, Michael A Mooney, Garrett J Repp, Peter Nakaji, Steve W Chang, Jay D Turner, U Kumar Kakarla
STUDY DESIGN: Objective and subjective fluoroscopic assessments of a new synthetic spine model. OBJECTIVE: To analyze the fluoroscopic performance and fidelity to human tissue of a new synthetic spine model. SUMMARY OF BACKGROUND DATA: The [blinded for review] Biomimetic Spine project aims to develop a 3-dimensional (3D) printed, synthetic spine model that will one day replace cadaveric tissue in spine biomechanical research. A crucial component to any biomimetic spine model is that it performs similarly to cadaveric tissue on standard diagnostic imaging modalities...
May 10, 2018: Spine
https://www.readbyqxmd.com/read/29744116/spinal-manipulation-and-therapeutic-exercises-in-treating-post-surgical-resurgent-lumbar-radiculopathy
#12
Vinicius Tieppo Francio, Chris Towery, Saeid Davani, Tony Brown
Lumbar radiculopathy due to disc herniation is one of the most common conditions seen in orthopedic practices worldwide. Surgical intervention is often necessary, and most patients improve without reoccurrences. The purpose of this case is to describe the successful outcome of post-surgical resurgent lumbar radiculopathy treated with spinal manipulation and therapeutic exercises. Here, we discuss the case of a 42-year-old male who received twelve treatments of spinal manipulation, in addition to therapeutic McKenzie methods exercises...
October 2017: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/29738767/mir-411-suppresses-acute-spinal-cord-injury-via-downregulation-of-fas-ligand-in-rats
#13
Zong-Ming Gong, Zhen-Yu Tang, Xiao-Liang Sun
OBJECTIVE: To explore the role of miR-411/FasL in acute spinal cord injury (ASCI). METHODS: The ASCI rat model was established, and expression of miR-411 and Fas ligand (FasL) were examined. Basso, Beattie and Bresnahan (BBB) score was used to evaluate the rats' neurological function. PC12 oxygen-glucose deprivation (OGD) model was also established. Gene manipulation (including miR-411 mimic or inhibitor) was used to modulate gene expression. Luciferase reporter assay was conducted to confirm the targeting relationship between miR-411 and FasL...
May 5, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29729835/to-scar-or-not-to-scar
#14
Aarti Narang, Binhai Zheng
A recent study indicates that reducing fibrotic scarring by genetically abrogating the proliferation of type A pericytes promotes axon regeneration and functional recovery after spinal cord injury. Questions remain regarding the identity of the cells being manipulated and the balance between the beneficial and detrimental effects of fibrotic scarring.
May 2, 2018: Trends in Molecular Medicine
https://www.readbyqxmd.com/read/29729250/application-of-optogenetics-in-the-study-of-pain-modulation
#15
REVIEW
Yu-Feng Xie, Jing Wang, Robert P Bonin
Intractable pain is the single most common cause of disability, affecting more than 20% of the population world-wide. There is accordingly a global effort to decipher how changes in the activity of nociceptive sensory afferents and dorsal horn cell populations contribute to the onset and maintenance of chronic pain. Through the application of advances in genetic techniques, there has been a surge in the success of efforts along this front. In particular, the past several years have brought rapid progress in the adaptation of optogenetic approaches to study and manipulate the activity of sensory afferents and spinal cord neurons in freely behaving animals...
May 2, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29726799/cervical-corpectomy-for-resection-of-ventral-intramedullary-capillary-hemangioma-with-circumferential-involvement-of-the-anterior-spinal-artery-case-report
#16
Jonathan A Forbes, Nathan Teschan, Samuel Hayden Jones, Phillip Parry, Luke Simonet, Narayana K Swamy
There is limited evidence to suggest that anterior approaches for the resection of ventral intramedullary lesions of the cervical spinal cord may result in superior neurological outcomes compared with those following more traditional posterior approaches. To the authors' knowledge, no report of an anterior approach to resect a ventral intramedullary capillary hemangioma exists in the literature. In the following paper, the case of a 75-year-old male who presented with progressive neck and left shoulder pain, weakness of the left hand, myelopathy, and gait imbalance is reported...
May 4, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29722306/dissecting-the-multifactorial-nature-of-demyelinating-disease
#17
REVIEW
Karolina Kucharova, William B Stallcup
Chondroitin sulfate proteoglycan-4 (CSPG4) is a surface component of two key cell types (oligodendrocyte progenitor cells (OPCs) and myeloid cells) present in lysolecithin-induced lesions in mouse spinal cord. Two types of CSPG4 manipulations have been used to study the roles of these cells in myelin damage and repair: (1) OPC and myeloid-specific ablation of CSPG4, and (2) transplantation of enhanced green fluorescent protein (EGFP)-labeled progenitors to distinguish between bone marrow-derived macrophages and resident microglia...
April 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29717546/the-dorsal-column-lesion-model-of-spinal-cord-injury-and-its-use-in-deciphering-the-neuron-intrinsic-injury-response
#18
REVIEW
Callan L Attwell, Mike van Zwieten, Joost Verhaagen, Matthew Rj Mason
The neuron-intrinsic response to axonal injury differs markedly between neurons of the peripheral and central nervous system. Following a peripheral lesion a robust axonal growth program is initiated, whereas neurons of the central nervous system do not mount an effective regenerative response. Increasing the neuron-intrinsic regenerative response would therefore be one way to promote axonal regeneration in the injured central nervous system. The large diameter sensory neurons located in the dorsal root ganglia are pseudo-unipolar neurons that project one axon branch into the spinal cord, and, via the dorsal column to the brain stem, and a peripheral process to the muscles and skin...
May 1, 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29713457/the-regional-effect-of-spinal-manipulation-on-the-pressure-pain-threshold-in-asymptomatic-subjects-a-systematic-literature-review
#19
REVIEW
Margaux Honoré, Charlotte Leboeuf-Yde, Olivier Gagey
Background: Spinal manipulation (SM) has been shown to have an effect on pain perception. More knowledge is needed on this phenomenon and it would be relevant to study its effect in asymptomatic subjects. Objectives: To compare regional effect of SM on pressure pain threshold (PPT) vs. sham, inactive control, mobilisation, another SM, and some type of physical therapy. In addition, we reported the results for the three different spinal regions. Method: A systematic search of literature was done using PubMed, Embase and Cochrane...
2018: Chiropractic & Manual Therapies
https://www.readbyqxmd.com/read/29706725/alleviation-of-neck-pain-by-the-non-surgical-rehabilitation-of-a-pathologic-cervical-kyphosis-to-a-normal-lordosis-a-cbp-%C3%A2-case-report
#20
Alyssa K Dennis, Paul A Oakley, Michael T Weiner, Tara A VanVranken, David A Shapiro, Deed E Harrison
[Purpose] To present a case of the therapeutic reversal of a cervical kyphosis into a lordosis in a patient who presented with neck pain and headaches. [Subject and Methods] A 24-year-old male irritated his neck while dancing. Upon examination it was revealed he had an excessive, 45 mm forward head translation and a 15° cervical kyphosis from C3-C6. The patient was treated with Chiropractic BioPhysics® methods aimed at restoring the cervical lordosis by mirror image® , neck extension exercises, cervical extension traction, and spinal manipulative therapy...
April 2018: Journal of Physical Therapy Science
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