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Spinal manipulation

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https://www.readbyqxmd.com/read/28924697/chiropractic-spinal-manipulation-and-the-risk-for-acute-lumbar-disc-herniation-a-belief-elicitation-study
#1
Cesar A Hincapié, J David Cassidy, Pierre Côté, Y Raja Rampersaud, Alejandro R Jadad, George A Tomlinson
PURPOSE: Chiropractic spinal manipulation treatment (SMT) is common for back pain and has been reported to increase the risk for lumbar disc herniation (LDH), but there is no high quality evidence about this. In the absence of good evidence, clinicians can have knowledge and beliefs about the risk. Our purpose was to determine clinicians' beliefs regarding the risk for acute LDH associated with chiropractic SMT. METHODS: Using a belief elicitation design, 47 clinicians (16 chiropractors, 15 family physicians and 16 spine surgeons) that treat patients with back pain from primary and tertiary care practices were interviewed...
September 18, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28920904/modeling-the-nonlinear-cortical-response-in-eeg-evoked-by-wrist-joint-manipulation
#2
Martijn P Vlaar, Georgios Birpoutsoukis, John Lataire, Maarten Schoukens, Alfred C Schouten, Johan Schoukens, Frans C T van der Helm
Joint manipulation elicits a response from the sensors in the periphery which, via the spinal cord, arrives in the cortex. The average evoked cortical response recorded using electroencephalography was shown to be highly nonlinear; a linear model can only explain 10% of the variance of the evoked response, and over 80% of the response is generated by nonlinear behavior. The goal of this study is to obtain a nonparametric nonlinear dynamic model, which can consistently explain the recorded cortical response requiring little a priori assumptions about model structure...
September 13, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28912629/spinal-manipulation-does-not-affect-pressure-pain-thresholds-in-the-absence-of-neuromodulators-a-randomized-controlled-trial
#3
Max K Jordon, Paul F Beattie, Sarah D'Urso, Sarah Scriven
BACKGROUND: Measurement of pressure pain threshold (PPT) is a way to determine one of the many potential treatment effects of spinal manipulative therapy. OBJECTIVE: To determine how multiple spinal manipulations administered in a single-session affected PPTs at local and distal sites in asymptomatic individuals. METHODS: Participants were randomly assigned into one of three groups: Group one (n = 18) received a lumbar manipulation followed by a cervical manipulation...
September 2017: Journal of Manual & Manipulative Therapy
https://www.readbyqxmd.com/read/28905384/heteromeric-%C3%AE-%C3%AE-%C3%A2-glycine-receptors-regulate-excitability-in-parvalbumin-expressing-dorsal-horn-neurons-through-phasic-and-tonic-glycinergic-inhibition
#4
M A Gradwell, K A Boyle, R J Callister, D I Hughes, B A Graham
The dorsal horn (DH) of the spinal cord is an important site for modality specific processing of sensory information and is essential for contextually relevant sensory experience. Parvalbumin-expressing inhibitory interneurons (PV + INs) have functional properties and connectivity that enables them to segregate tactile and nociceptive information. Here we examine inhibitory drive to PV + INs using targeted patch-clamp recording in spinal cord slices from adult transgenic mice that express enhanced green fluorescent protein in PV + INs...
September 14, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28904095/distinct-roles-for-motor-neuron-autophagy-early-and-late-in-the-sod1-g93a-mouse-model-of-als
#5
Noam D Rudnick, Christopher J Griffey, Paolo Guarnieri, Valeria Gerbino, Xueyong Wang, Jason A Piersaint, Juan Carlos Tapia, Mark M Rich, Tom Maniatis
Mutations in autophagy genes can cause familial and sporadic amyotrophic lateral sclerosis (ALS). However, the role of autophagy in ALS pathogenesis is poorly understood, in part due to the lack of cell type-specific manipulations of this pathway in animal models. Using a mouse model of ALS expressing mutant superoxide dismutase 1 (SOD1(G93A)), we show that motor neurons form large autophagosomes containing ubiquitinated aggregates early in disease progression. To investigate whether this response is protective or detrimental, we generated mice in which the critical autophagy gene Atg7 was specifically disrupted in motor neurons (Atg7 cKO)...
September 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28900571/cavitation-sounds-during-cervicothoracic-spinal-manipulation
#6
James Dunning, Firas Mourad, Andrea Zingoni, Raffaele Iorio, Thomas Perreault, Noah Zacharko, César Fernández de Las Peñas, Raymond Butts, Joshua A Cleland
BACKGROUND: No study has previously investigated the side, duration or number of audible cavitation sounds during high-velocity low-amplitude (HVLA) thrust manipulation to the cervicothoracic spine. PURPOSE: The primary purpose was to determine which side of the spine cavitates during cervicothoracic junction (CTJ) HVLA thrust manipulation. Secondary aims were to calculate the average number of cavitations, the duration of cervicothoracic thrust manipulation, and the duration of a single cavitation...
August 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/28884424/immunobiology-of-spinal-cord-injuries-and-potential-therapeutic-approaches
#7
REVIEW
Aabra Ahmed, Arun-Angelo Patil, Devendra K Agrawal
The incidence of spinal cord injuries (SCI) is high every year. As the spinal cord is the highway that allows for the brain to control the rest of the body, spinal cord injuries greatly impact the quality of life of the patients. The SCI include the primary response consisting of the initial accident-induced damage and the secondary response that is characterized by damage due to inflammation and biological responses. Astrocytes are the first to act at the site of the injury, forming a glial scar and attracting immune cells...
September 7, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28881124/minimally-invasive-anterior-decompression-technique-without-instrumented-fusion-for-huge-ossification-of-the-posterior-longitudinal-ligament-in-the-thoracic-spine-technical-note-and-literature-review
#8
Jae Won Yu, Sang-O Yun, Chang-Sheng Hsieh, Sang-Ho Lee
OBJECTIVE: Several surgical methods have been reported for treatment of ossification of the posterior longitudinal ligament (OPLL) in the thoracic spine. Despite rapid innovation of instruments and techniques for spinal surgery, the postoperative outcomes are not always favorable. This article reports a minimally invasive anterior decompression technique without instrumented fusion, which was modified from the conventional procedure. The authors present 2 cases of huge beak-type OPLL...
September 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28878486/treating-slouchy-hyperkyphosis-posture-with-chiropractic-biophysics-%C3%A2-a-case-report-utilizing-a-multimodal-mirror-image-%C3%A2-rehabilitation-program
#9
Miles O Fortner, Paul A Oakley, Deed E Harrison
[Purpose] To present a case of the non-surgical reduction of 'slouchy' hyperkyphosis posture utilizing the multimodal Chiropractic BioPhysics(®) rehabilitation program emphasizing the mirror image(®) concept. [Subject and Methods] A 27-year-old female presented suffering from neck and back pains, headaches and gait dysfunction. The patient was treated 30 times over a period of 6-months. Treatment consisted of anterior thoracic translation, thoracic extension, and head retraction exercises as well as spinal traction and spinal manipulation...
August 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28878485/non-surgical-relief-of-cervical-radiculopathy-through-reduction-of-forward-head-posture-and-restoration-of-cervical-lordosis-a-case-report
#10
Bret M Wickstrom, Paul A Oakley, Deed E Harrison
[Purpose] To present a case demonstrating the relief of cervical radiculopathy following the dramatic reduction of forward head posture and restoration of the cervical lordosis by use of a multi-modal rehabilitation program incorporating cervical extension traction. [Subject and Methods] A 31-year-old male patient presented with severe cervical radiculopathy and muscle weakness as well as neck pain. The patient had limited neck range of motion, and multiple positive orthopedic tests. Radiography revealed excessive forward head posture with a cervical kyphosis...
August 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28877964/constitutive-activity-of-5-ht2c-receptors-is-present-following-incomplete-spinal-cord-injury-but-is-not-modified-after-chronic-ssri-or-baclofen-treatment
#11
Vicki Maria Tysseling, David A Klein, Rebecca Imhoff-Manuel, Marin Manuel, Charles J Heckman, Matthew C Tresch
Following spinal cord injury (SCI), reflexes become hyperexcitable, leading to debilitating muscle spasms and compromised motor function. Previous work has described adaptations in spinal systems that might underlie this hyperexcitability, including an increase in constitutively active 5-HT2C receptors in spinal motoneurons. That work, however, examined adaptations following complete transection SCI, whereas SCI in humans is usually anatomically and functionally incomplete. We therefore evaluated whether constitutive activity of 5-HT2C receptors contributes to reflex hyperexcitability in an incomplete compression model of SCI and to spasms in vitro and in vivo...
September 6, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28874984/neuropathic-pain-after-spinal-surgery
#12
REVIEW
Jae Hwan Cho, Jae Hyup Lee, Kwang-Sup Song, Jae-Young Hong
Neuropathic pain after spinal surgery, the so-called failed back surgery syndrome (FBSS), is a frequently observed troublesome disease entity. Although medications may be effective to some degree, many patients continue experiencing intolerable pain and functional disability. Only gabapentin has been proven effective in patients with FBSS. No relevant studies regarding manipulation or physiotherapy for FBSS have been published. Spinal cord stimulation (SCS) has been widely investigated as a treatment option for chronic neuropathic pain, including FBSS...
August 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/28873157/spinal-manipulative-therapy-for-low-back-pain-reply
#13
Neil M Paige, Sally C Morton, Paul G Shekelle
No abstract text is available yet for this article.
September 5, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28873153/spinal-manipulative-therapy-for-low-back-pain
#14
Romy Lauche, Tobias Sundberg, Holger Cramer
No abstract text is available yet for this article.
September 5, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28871033/reticulospinal-contributions-to-gross-hand-function-after-human-spinal-cord-injury
#15
Stuart N Baker, Monica A Perez
Multiple descending motor pathways likely contribute to the recovery of hand motor function following spinal cord injury (SCI). Reticulospinal neurons project to spinal motor neurons controlling hand muscles and extensively sprout into gray matter structures after SCI; therefore, it has been proposed that the reticulospinal tract is one of the descending motor pathways involved in recovery of hand function after injury. To test this hypothesis, we examined the StartReact response, an involuntary release of a planned movement via a startling stimulus that engages the reticulospinal tract, by measuring reaction times from electromyographic activity in an intrinsic finger muscle during three motor tasks requiring different degrees of hand dexterity: index finger abduction, a precision grip, and a power grip...
September 4, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28864353/manipulation-of-neural-progenitor-fate-through-the-oxygen-sensing-pathway
#16
REVIEW
Yuan Xie, William E Lowry
Neural progenitor cells hold significant promise in a variety of clinical settings. While both the brain and spinal cord harbor endogenous neural progenitor or stem cells, they typically are not capable of repopulating neural populations in case of injury or degenerative disease. In vitro systems for the culture of neural progenitors has come a long ways due to advances in the method development. Recently, many groups have shown that manipulation of the oxygen-sensing pathway leading to activation of hypoxia inducible factors (HIFs) that can influence the proliferation, differentiation or maturation of neural progenitors...
August 31, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28860091/a-quantitative-study-of-neurochemically-defined-populations-of-inhibitory-interneurons-in-the-superficial-dorsal-horn-of-the-mouse-spinal-cord
#17
Kieran A Boyle, Maria Gutierrez-Mecinas, Erika Polgár, Nicole Mooney, Emily O'Connor, Takahiro Furuta, Masahiko Watanabe, Andrew J Todd
Around a quarter of neurons in laminae I-II of the dorsal horn are inhibitory interneurons. These play an important role in modulating somatosensory information, including that perceived as pain or itch. Previous studies in rat identified four largely non-overlapping neurochemical populations among these cells, defined by expression of galanin, neuropeptide Y (NPY), neuronal nitric oxide synthase (nNOS) or parvalbumin. The galanin cells were subsequently shown to coexpress dynorphin. Several recent studies have used genetically modified mice to investigate the function of different interneuron populations, and it is therefore important to determine whether the same pattern applies in mouse, and to estimate the relative sizes of these populations...
August 30, 2017: Neuroscience
https://www.readbyqxmd.com/read/28851924/feeling-stiffness-in-the-back-a-protective-perceptual-inference-in-chronic-back-pain
#18
Tasha R Stanton, G Lorimer Moseley, Arnold Y L Wong, Gregory N Kawchuk
Does feeling back stiffness actually reflect having a stiff back? This research interrogates the long-held question of what informs our subjective experiences of bodily state. We propose a new hypothesis: feelings of back stiffness are a protective perceptual construct, rather than reflecting biomechanical properties of the back. This has far-reaching implications for treatment of pain/stiffness but also for our understanding of bodily feelings. Over three experiments, we challenge the prevailing view by showing that feeling stiff does not relate to objective spinal measures of stiffness and objective back stiffness does not differ between those who report feeling stiff and those who do not...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28851418/survey-of-integrative-lumbar-spinal-stenosis-treatment-in-korean-medicine-doctors-preliminary-data-for-clinical-practice-guidelines
#19
Yoon Jae Lee, Joon-Shik Shin, Jinho Lee, Me-Riong Kim, Yong-Jun Ahn, Ye-Sle Shin, Ki Byung Park, Byung-Cheul Shin, Myeong Soo Lee, Joo-Hee Kim, Jae-Heung Cho, In-Hyuk Ha
BACKGROUND: Considering that large variations exist amongst practitioners in lumbar disorder management and the significant costs that lumbar disorders incur, determining clinical practice patterns to provide preliminary data for standardization should be given higher priority. Lumbar spinal stenosis (LSS) is commonly treated using integrative non-surgical methods by Korean medicine doctors (KMDs) in Korea, and this is the first study to assess current Korean medicine practice trends for LSS...
August 29, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28850369/clinical-outcome-following-anterior-arthrodesis-in-patients-with-presumed-sacroiliac-joint-pain
#20
Bo Nyström, Birgitta Gregebo, Adam Taube, Stig-Olof Almgren, Birgitta Schillberg, Yingyan Zhu
BACKGROUND: It has been reported that in 13-32% of patients with chronic low back pain, the pain may originate in the sacroiliac (SI) joints. When treatment of these patients with analgesics and physiotherapy has failed, a surgical solution may be discussed. Results of such surgery are often based on small series, retrospective analyses or studies using a minimal invasive technique, frequently sponsored by manufacturers. PURPOSE: To report the clinical outcome concerning pain, function and quality of life following anterior arthrodesis in patients presumed to have SI joint pain using validated questionnaires pre- and post-operatively...
July 24, 2017: Scandinavian Journal of Pain
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