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https://www.readbyqxmd.com/read/28346201/a-pilot-stability-study-of-dehydroepiandrosterone-rapid-dissolving-tablets-prepared-by-extemporaneous-compounding
#1
Steven D Rush, Charlene Vernak, Fang Zhao
Dehydroepiandrosterone supplementation is used to treat a variety of conditions. Rapid-dissolving tablets are a relatively novel choice for compounded dehydroepiandrosterone dosage forms. While rapid-dissolving tablets offer ease of administration, there are uncertainties about the physical and chemical stability of the drug and dosage form during preparation and over long-term storage. This study was designed to evaluate the stability of dehydroepiandrosterone rapid-dissolving tablets just after preparation and over six months of storage...
January 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28346017/strong-in-the-face-of-adversity
#2
Simoni Binoy
Palliative care provides holistic care to individuals in life-threatening or life-limiting conditions. This narrative describes the journey of Kanchan. A strong lady and a doting mother, she came to the hospital by choice, in immense pain and with swelling. Her narrative illustrates how the palliative approach draws out the inner strengths of individuals by focusing on their issues and needs. Kanchan was able to benefit from physiotherapy to reduce the risk of lymphoedema after surgery for breast cancer. Her narrative illustrates how she found comfort and relief, ably supported by the dedicated hospital team...
March 27, 2017: Journal of Pain & Palliative Care Pharmacotherapy
https://www.readbyqxmd.com/read/28345698/ethylcellulose-oleogels-for-lipophilic-bioactive-delivery-effect-of-oleogelation-on-in-vitro-bioaccessibility-and-stability-of-beta-carotene
#3
Chloe M O Sullivan, Maya Davidovich-Pinhas, Amanda J Wright, Shai Barbut, Alejandro G Marangoni
The in vitro lipolysis and β-carotene (BC) transfer from oil to aqueous phase of canola oil ethylcellulose (EC) oleogels were measured using a static monocompartmental model simulating oral, gastric, and duodenal digestive stages. The effects of EC oleogelation on gel in vitro digestibility were examined, using un-structured canola oil as a control. The physicochemical properties of oleogels containing BC were also measured. It was found that oleogels made with 10% 10 cP and 10% 20 cP did not differ significantly in their extent of lipolysis or BC transfer compared to canola oil; however 10% 45 cP and 15...
March 27, 2017: Food & Function
https://www.readbyqxmd.com/read/28344734/aerobic-capacity-is-related-to-repeated-sprint-ability-with-sprint-distances-less-than-40-meters
#4
Gabriel J Sanders, Zachary Turner, Brian Boos, Corey A Peacock, Willard Peveler, Alar Lipping
Research is inconclusive regarding the association between aerobic fitness (objectively measured VO2max) and repeated sprint performance when the sprints are less than 40 meters. Soccer athletes must be able to repeat sprints without significant decreases in speed and strength and conditioning coaches need to better understand if aerobic fitness is related to repeated sprint ability (RSA). Twenty (10 male, 10 female) Division I soccer athletes first completed a graded maximal treadmill test to measure VO2max...
2017: International Journal of Exercise Science
https://www.readbyqxmd.com/read/28342783/effect-of-storage-on-the-physical-stability-of-thin-polymethacrylate-perphenazine-films
#5
Kristiina Korhonen, Elina Smolander, Ossi Korhonen, Jarkko Ketolainen, Riikka Laitinen
We evaluated the physical stability of thin polymethacrylate-drug films under three different storage conditions by X-ray powder diffraction, differential scanning calorimetry, scanning electron microscopy, polarized light microscopy, and Fourier transform infrared spectroscopy. Mechanical properties i.e. elongation, mechanical strength, and in vitro drug release from the thin films were also determined during storage. The films consisted of ammonium methacrylate copolymer (RLPO)/dimethylaminoethyl methacrylate copolymer (EPO), polyvinylpyrroline (PVP)/polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (Soluplus) and perphenazine (PPZ)...
March 22, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28341826/poly-ethylmethacrylate-co-diethylaminoethyl-acrylate-coating-improves-endothelial-re-population-bio-mechanical-and-anti-thrombogenic-properties-of-decellularized-carotid-arteries-for-blood-vessel-replacement
#6
Elena López-Ruiz, Seshasailam Venkateswaran, Macarena Perán, Gema Jiménez, Salvatore Pernagallo, Juan J Díaz-Mochón, Olga Tura-Ceide, Francisco Arrebola, Juan Melchor, Juan Soto, Guillermo Rus, Pedro J Real, María Diaz-Ricart, Antonio Conde-González, Mark Bradley, Juan A Marchal
Decellularized vascular scaffolds are promising materials for vessel replacements. However, despite the natural origin of decellularized vessels, issues such as biomechanical incompatibility, immunogenicity risks and the hazards of thrombus formation, still need to be addressed. In this study, we coated decellularized vessels obtained from porcine carotid arteries with poly (ethylmethacrylate-co-diethylaminoethylacrylate) (8g7) with the purpose of improving endothelial coverage and minimizing platelet attachment while enhancing the mechanical properties of the decellularized vascular scaffolds...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28340784/separation-of-20-coumarin-derivatives-using-the-capillary-electrophoresis-method-optimized-by-a-series-of-doehlert-experimental-designs
#7
Michał Woźniakiewicz, Marta Gładysz, Paweł M Nowak, Justyna Kędzior, Paweł Kościelniak
The aim of this study was to develop the first CE-based method enabling separation of 20 structurally similar coumarin derivatives. To facilitate method optimization a series of three consequent Doehlert experimental designs with the response surface methodology was employed, using number of peaks and the adjusted time of analysis as the selected responses. Initially, three variables were examined: buffer pH, ionic strength and temperature (No. 1 Doehlert design). The optimal conditions provided only partial separation, on that account, several buffer additives were examined at the next step: organic cosolvents and cyclodextrin (No...
May 15, 2017: Talanta
https://www.readbyqxmd.com/read/28340695/long-term-follow-up-after-autologous-adipose-derived-stromal-vascular-fraction-injection-into-fingers-in-systemic-sclerosis-patients
#8
A Daumas, J Magalon, E Jouve, R Truillet, D Casanova, L Giraudo, J Veran, A Benyamine, F Dignat-George, G Magalon, F Sabatier, B Granel
INTRODUCTION: Hand involvement confers a substantial handicap in work and daily activities in patients with Systemic sclerosis (SSc). Autologous adipose-derived stromal vascular fraction is as an easily accessible source of cells with regenerative effects. We previously performed a phase I open-label clinical trial (NTC01813279) assessing the safety of subcutaneous injection of autologous adipose-derived stromal vascular fraction. Six and 12-month data have been reported. As patients were followed in our medical centre, we report their longer-term outcome beyond the end of the trial...
January 2017: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/28339852/relationship-between-back-pain-and-urinary-incontinence-in-the-canadian-population
#9
Tanner Cassidy, Amanda Fortin, Stephanie Kaczmer, Jessica T L Shumaker, Jessica Szeto, Stéphanie J Madill
Background: Back problems and urinary incontinence (UI) have been found to co-occur more frequently than would be predicted by chance. Objective: The aim of this study was to estimate the associations between UI and back problems in the Canadian men and women. Design: This was an observational, cross-sectional study. Methods: The 2011-2012 Statistics Canada Canadian Community Health Survey (CCHS) provided the data. The CCHS surveyed 125,645 adults providing a representative sample of the Canadian population...
March 1, 2017: Physical Therapy
https://www.readbyqxmd.com/read/28339628/using-digital-interventions-to-improve-the-cardiometabolic-health-of-populations-a-meta-review-of-reporting-quality
#10
Adrienne O'Neil, Fiona Cocker, Patricia Rarau, Shaira Baptista, Mandy Cassimatis, C Barr Taylor, Annie Y S Lau, Nitya Kanuri, Brian Oldenburg
Objectives.: We conducted a meta-review to determine the reporting quality of user-centered digital interventions for the prevention and management of cardiometabolic conditions. Materials and Methods.: Using predetermined inclusion criteria, systematic reviews published between 2010 and 2015 were identified from 3 databases. To assess whether current evidence is sufficient to inform wider uptake and implementation of digital health programs, we assessed the quality of reporting of research findings using (1) endorsement of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, (2) a quality assessment framework (eg, Cochrane risk of bias assessment tool), and (3) 8 parameters of the Consolidated Standards of Reporting Trials of Electronic and Mobile HEalth Applications and onLine TeleHealth (CONSORT-eHEALTH) guidelines (developed in 2010)...
February 11, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28339544/laxatives-do-not-improve-symptoms-of-opioid-induced-constipation-results-of-a-patient-survey
#11
Anton Emmanuel, Martin Johnson, Paula McSkimming, Sara Dickerson
Introduction.:  Laxatives are commonly used to treat opioid-induced constipation, the commonest and most bothersome complication of opioids. However, laxatives have a nonspecific action and do not target underlying mechanisms of opioid-induced constipation; their use is associated with abdominal symptoms that negatively impact quality of life. Objective.:  To assess the effects of laxatives in patients taking opioids for chronic pain. Methods...
October 8, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28339014/effects-of-remote-ischemic-post%C3%A2-conditioning-on-fracture-healing-in-rats
#12
Meng Zhou, Shibao Lu, Guowei Lu, Jiang Huang, Limin Liu, Shuai An, Zheng Li, Huiliang Shen
Remote ischemic post‑conditioning (RIPC) is an established method to activate the hypoxia‑inducible factor‑1α (HIF‑1α) pathway, which is involved in the impairment of fracture healing. However, the role of RIPC in fracture healing remains to be fully elucidated. In the present study, rats received fractures and were divided into two groups: Control and RIPC, in which hind limb occlusion was performed. Rats were sacrificed at 7, 14, 28 and 42 days subsequent to tibial fracture. Micro‑computed tomography was performed to measure healing of the bone tissue and biomechanical testing was used to test mechanical strength...
March 22, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28338975/drought-and-reproductive-effort-interact-to-control-growth-of-a-temperate-broadleaved-tree-species-fagus-sylvatica
#13
Andrew J Hacket-Pain, Jonathan G A Lageard, Peter A Thomas
Interannual variation in radial growth is influenced by a range of physiological processes, including variation in annual reproductive effort, although the importance of reproductive allocation has rarely been quantified. In this study, we use long stand-level records of annual seed production, radial growth (tree ring width) and meteorological conditions to analyse the relative importance of summer drought and reproductive effort in controlling the growth of Fagus sylvatica L., a typical masting species. We show that both summer drought and reproductive effort (masting) influenced growth...
March 17, 2017: Tree Physiology
https://www.readbyqxmd.com/read/28338423/assessment-of-leg-muscles-mechanical-capacities-which-jump-loading-and-variable-type-provide-the-most-reliable-outcomes
#14
Amador García-Ramos, Belén Feriche, Alejandro Pérez-Castilla, Paulino Padial, Slobodan Jaric
This study aimed to explore the strength of the force-velocity (F-V) relationship of lower limb muscles and the reliability of its parameters (maximum force [F0], slope [a], maximum velocity [V0], and maximum power [P0]). Twenty-three men were tested in two different jump types (squat and countermovement jump: SJ and CMJ), performed under two different loading conditions (free weight and Smith machine: Free and Smith) with 0, 17, 30, 45, 60, and 75 kg loads. The maximum and averaged values of F and V were obtained for the F-V relationship modelling...
March 24, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28338375/an-updated-review-of-the-applied-physiology-of-american-collegiate-football-the-physical-demands-strength-conditioning-nutritional-considerations-and-injury-characteristics-of-america-s-favourite-game
#15
Hugh H K Fullagar, Robert McCunn, Andrew Murray
Whilst there are various avenues for performance improvement within collegiate American football (AF), there is no comprehensive evaluation of the collective array of resources around performance, physical conditioning and injury and training/game characteristics to guide future research and inform practitioners. Accordingly, the aim of the present review was to provide a current examination of these areas within collegiate AF. Recent studies show that there is a wide range of body compositions and strength characteristics between players, which appear to be influenced by playing position, level of play, training history/programming and time of season...
March 24, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28338368/alginate-and-whey-protein-based-multilayered-particles-production-characterization-and-resistance-to-ph-ionic-strength-and-artificial-gastric-intestinal-fluid
#16
Gislaine Ferreira Nogueira, Ana Silvia Prata, Carlos Raimundo Ferreira Grosso
Multiple layers of whey protein and sodium alginate were assembled onto gelled alginate microparticles using electrostatic interaction. An experimental design was employed to evaluate the effect of the concentration of both hydrocolloids on the amount of protein that was adsorbed. In the first layer, a higher protein adsorption 32.5% w/w was obtained at pH 3.75. In the multilayered particle, the protein adsorbed reached 64.9% w/w. An analysis of protein solubilization verified that 22% w/w was solubilized at an acidic pH (pH 2...
March 24, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28338355/the-potential-for-a-targeted-strength-training-programme-to-decrease-asymmetry-and-increase-performance-a-proof-of-concept-in-sprinting
#17
Scott R Brown, Erin R Feldman, Matt R Cross, Eric R Helms, Bruno Marrier, Pierre Samozino, Jean-Benoît Morin
The global application of horizontal force (FH) via hip extension is related to improvements in sprint performance (e.g. maximal velocity [vmax] and power [Pmax]). Little is known regarding the contribution of individual-leg FH and how a difference between the legs (asymmetry) might subsequently affect sprint performance. We assessed a single male athlete for pre-post outcomes of a targeted hip extension training programme on FH asymmetry and sprint performance metrics. An instrumented non-motorised treadmill was used to obtain individual-leg and global sprint kinetics and determine the athlete's strong and weak leg, with regards to the ability to produce FH while sprinting...
March 24, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28338313/ultimate-control-of-rate-dependent-adhesion-for-reversible-transfer-process-via-thin-elastomeric-layer
#18
Chan Kim, Min-Ah Yoon, Bongkyun Jang, Jae-Hyun Kim, Hak-Joo Lee, Kwang-Seop Kim
Adhesion between a stamp with an elastomeric layer and various devices or substrates is crucial to successfully fabricate flexible electronics using a transfer process. Although various transfer processes using stamps with different adhesion strengths have been suggested, the controllable range of adhesion is still limited to a narrow range. To precisely transfer devices onto selected substrates, however, the difference in adhesion between the picking and placing processes should be large enough to achieve a high yield...
March 24, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28338087/gs%C3%AE-controls-cortical-bone-quality-by-regulating-osteoclast-differentiation-via-camp-pka-and-%C3%AE-catenin-pathways
#19
Girish Ramaswamy, Hyunsoo Kim, Deyu Zhang, Vitali Lounev, Joy Y Wu, Yongwon Choi, Frederick S Kaplan, Robert J Pignolo, Eileen M Shore
Skeletal bone formation and maintenance requires coordinate functions of several cell types, including bone forming osteoblasts and bone resorbing osteoclasts. Gsα, the stimulatory subunit of heterotrimeric G proteins, activates downstream signaling through cAMP and plays important roles in skeletal development by regulating osteoblast differentiation. Here, we demonstrate that Gsα signaling also regulates osteoclast differentiation during bone modeling and remodeling. Gnas, the gene encoding Gsα, is imprinted...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28337153/defense-responses-to-short-term-hypoxia-and-seawater-acidification-in-the-thick-shell-mussel-mytilus-coruscus
#20
Yanming Sui, Yimeng Liu, Xin Zhao, Sam Dupont, Menghong Hu, Fangli Wu, Xizhi Huang, Jiale Li, Weiqun Lu, Youji Wang
The rising anthropogenic atmospheric CO2 results in the reduction of seawater pH, namely ocean acidification (OA). In East China Sea, the largest coastal hypoxic zone was observed in the world. This region is also strongly impacted by ocean acidification as receiving much nutrient from Changjiang and Qiantangjiang, and organisms can experience great short-term natural variability of DO and pH in this area. In order to evaluate the defense responses of marine mussels under this scenario, the thick shell mussel Mytilus coruscus were exposed to three pH/pCO2 levels (7...
2017: Frontiers in Physiology
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