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https://www.readbyqxmd.com/read/29341828/biosensors-for-spatiotemporal-detection-of-reactive-oxygen-species-in-cells-and-tissues
#1
Marie Erard, Sophie Dupre-Crochet, Oliver Nusse
Redox biology has become a major issue in numerous areas of physiology. Reactive oxygen species (ROS) have a broad range of roles from signal transduction to growth control and cell death. To understand the nature of these roles, accurate measurement of the reactive compounds is required. An increasing number of tools for ROS detection is available; however, specificity and sensitivity of these tools are often insufficient. Furthermore, their specificity has been rarely evaluated in complex physiological conditions...
January 17, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29341340/bias-from-restricting-to-live-births-when-estimating-effects-of-prescription-drug-use-on-pregnancy-complications-a-simulation
#2
Elizabeth A Suarez, Suzanne N Landi, Mitchell C Conover, Michele Jonsson Funk
PURPOSE: Administrative claim databases are increasingly being used to study the safety of medication exposures during pregnancy. These studies are restricted to live births due to a reliance on algorithms for estimating gestational age that are based on codes associated with live delivery. Conditioning on live birth may induce selection bias when studying the effect of a drug on a pregnancy complication if fetal death is a competing risk for the complication or is caused by the complication...
January 17, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29341329/violence-and-child-mental-health-in-brazil-the-itabora%C3%A3-youth-study-methods-and-findings
#3
I A Bordin, C S Duarte, W S Ribeiro, C S Paula, E S F Coutinho, A Sourander, J A Rønning
OBJECTIVES: To demonstrate a study design that could be useful in low-resource and violent urban settings and to estimate the prevalence of child violence exposure (at home, community, and school) and child mental health problems in a low-income medium-size city. METHODS: The Itaboraí Youth Study is a Norway-Brazil collaborative longitudinal study conducted in Itaboraí city (n = 1409, 6-15 year olds). A 3-stage probabilistic sampling plan (random selection of census units, eligible households, and target child) generated sampling weights that were used to obtain estimates of population prevalence rates...
January 17, 2018: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/29341191/working-and-caring-for-a-child-with-chronic-illness-a-review-of-current-literature
#4
A M Kish, P A Newcombe, D M Haslam
BACKGROUND: Advances in medical knowledge have contributed to the increase in the number of children living with some form of long-term chronic illness or condition. As a consequence of these advancements, treatments that are more accessible and easier to administer, usually within a child's home, have been developed. However, this may mean that parents take on greater treatment responsibility and require extra time and energy to meet these tasks, additional to other responsibilities...
January 16, 2018: Child: Care, Health and Development
https://www.readbyqxmd.com/read/29340001/neuromuscular-control-during-the-bench-press-movement-in-an-elite-disabled-and-able-bodied-athlete
#5
Artur Gołaś, Anna Zwierzchowska, Adam Maszczyk, Michał Wilk, Petr Stastny, Adam Zając
The disabled population varies significantly in regard to physical fitness, what is conditioned by the damage to the locomotor system. Recently there has been an increased emphasis on the role of competitive sport in enhancing health and the quality of life of individuals with disability. One of the sport disciplines of Paralympics is the flat bench press. The bench press is one of the most popular resistance exercises used for the upper body in healthy individuals. It is used not only by powerlifters, but also by athletes in most strength-speed oriented sport disciplines...
December 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/29338267/theory-for-the-liquid-liquid-phase-separation-in-aqueous-antibody-solutions
#6
Miha Kastelic, Vojko Vlachy
This study presents the theory for liquid--liquid phase separation for systems of molecules modeling monoclonal antibodies. Individual molecule is depicted as an assembly of seven hard spheres, organized to mimic the Y--shaped antibody. We consider the antibody--antibody interactions either through Fab, Fab' (two Fab fragments may be different), or Fc domain. Interaction between these three domains of the molecule (hereafter denoted as A, B, and C, respectively) is modeled by a short--range square--well attraction...
January 16, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29337897/long-term-mechanical-behavior-of-nano-silica-sol-grouting
#7
Dongjiang Pan, Nong Zhang, Chenghao Zhang, Deyu Qian, Changliang Han, Sen Yang
The longevity of grouting has a significant effect on the safe and sustainable operation of many engineering projects. A 500-day experiment was carried out to study the long-term mechanical behavior of nano silica sol grouting. The nano silica sol was activated with different proportions of a NaCl catalyst and cured under fluctuating temperature and humidity conditions. The mechanical parameters of the grout samples were tested using an electrohydraulic uniaxial compression tester and an improved Vicat instrument...
January 16, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29337881/effects-of-polypropylene-orientation-on-mechanical-and-heat-seal-properties-of-polymer-aluminum-polymer-composite-films-for-pouch-lithium-ion-batteries
#8
Fangxinyu Zeng, Jinyao Chen, Feng Yang, Jian Kang, Ya Cao, Ming Xiang
In this study, polyamide-aluminum foil-polypropylene (PA-Al-PP) composite films with different orientation status of the PP layer were prepared, and their morphology, tensile, peeling and heat seal behavior were studied. The comparative study of tensile and fracture behaviors of single-layer film of PA, Al and PP, as well as the composite films of PA-Al, PP-Al and PA-Al-PP revealed that in PA-Al-PP composite film, the PA layer with the highest tensile strength can share the tensile stress from the Al layer during stretching, while the PP layer with the lowest tensile strength can prevent further development of the small cracks on boundary of the Al layer during stretching...
January 16, 2018: Materials
https://www.readbyqxmd.com/read/29337830/exploring-the-effects-of-playing-formations-on-tactical-behaviour-and-external-workload-during-football-small-sided-games
#9
Jorge Baptista, Bruno Travassos, Bruno Gonçalves, Paulo Mourão, João L Viana, Jaime Sampaio
This study aimed to identify the effects of playing formations on tactical behaviour and external workload during football small-sided games. Twenty-three semi-professional footballers integrated three different playing formations in a 7-a-side small-sided game, according to their specific player positions: team 4:3:0 (4 defenders, 3 midfielders); team 4:1:2 (4 defenders, 1 midfielder, 2 forwards); and team 0:4:3 (4 midfielders, 3 forwards). Based on players' movement trajectories, the following individual and collective tactical variables were calculated: total distance covered and distance covered while walking, jogging, running and sprinting, distance from each player to both own and opponent's team centroid (Dist CG and Dist OPP CG, respectively), individual area, team length, team width and surface area...
January 4, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29337185/proliposome-tablets-manufactured-using-a-slurry-driven-lipid-enriched-powders-development-characterization-and-stability-evaluation
#10
Iftikhar Khan, Sakib Yousaf, Sneha Subramanian, Mohamed Albed Alhnan, Waqar Ahmed, Abdelbary Elhissi
Proliposome powders were prepared via a slurry method using sorbitol or D-mannitol as carbohydrate carriers in 1:10 or 1:15 w/w lipid phase to carrier ratios. Soya phosphatidylcholine (SPC) and cholesterol were employed as a lipid phase and Beclometasone dipropionate (BDP) was incorporated as a model drug. Direct compaction using a Minipress was applied on the lipid-enriched powder in order to manufacture proliposome tablets. Sorbitol-based proliposome tablets in a 1:15 w/w ratio were found to be the best formulation as it exhibited excellent powder flowability with an angle of repose of 25...
January 11, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29336820/micro-ct-and-micro-fe-analysis-of-pedicle-screw-fixation-under-different-loading-conditions
#11
Y Chevalier, M Matsuura, S Krüger, C Fleege, M Rickert, M Rauschmann, C Schilling
Anchorage of pedicle screw instrumentation in the elderly spine with poor bone quality remains challenging. In this study, micro finite element (µFE) models were used to assess the specific influence of screw design and the relative contribution of local bone density to fixation mechanics. These were created from micro computer tomography (µCT) scans of vertebras implanted with two types of pedicle screws, including a full region-or-interest of 10 mm radius around each screw, as well as submodels for the pedicle and inner trabecular bone of the vertebral body...
December 26, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29336645/physical-exercise-prior-to-hematopoietic-stem-cell-transplantation-a-feasibility-study
#12
Inge E P M van Haren, J Bart Staal, Carin M Potting, Femke Atsma, Thomas J Hoogeboom, Nicole M A Blijlevens, Maria W G Nijhuis-van der Sanden
PURPOSE: This study explores the feasibility and preliminary effectiveness of an exercise program in people scheduled for hematopoietic stem cell transplantation (HSCT). METHODS: In this controlled clinical trial, we compare pre-transplantation exercise to no exercise in the waiting period for an allogeneic of autologous HSCT. The supervised individually tailored exercise program (4-6 weeks) consisted of aerobic endurance, muscle strength, and relaxation exercises, administered twice a week in the period prior to HSCT...
January 16, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29335557/a-framework-for-quantifying-the-relationship-between-intensity-and-severity-of-impact-of-disturbance-across-types-of-events-and-species
#13
Aiko Iwasaki, Takashi Noda
Understanding the impacts of natural disturbances on wildlife populations is a central task for ecologists; in general, the severity of impact of a disturbance (e.g., the resulting degree of population decline) is likely to depend primarily on the disturbance intensity (i.e., strength of forcing), type of disturbance, and species vulnerability. However, differences among disturbance events in the physical units of forcing and interspecific differences in the temporal variability of population size under normal (non-disturbance) conditions hinder comprehensive analysis of disturbance severity...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29335327/gps-experiences-of-diagnosing-and-managing-childhood-eczema-a-qualitative-study-in-primary-care
#14
Emma Le Roux, Kingsley Powell, Jonathan P Banks, Matthew J Ridd
BACKGROUND: Eczema is common among children, and in the UK the majority are managed by GPs. The most common cause of poor disease control is incorrect use of topical treatments. There is a lack of research into the challenges faced by GPs in diagnosing and managing this condition. AIM: To explore the experiences of GPs in assessing and managing children with eczema. DESIGN AND SETTING: Qualitative study in primary care in England. METHOD: Semi-structured interviews with 15 GPs were audiorecorded, transcribed verbatim, and analysed thematically using the framework method...
January 15, 2018: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/29335191/effects-of-alumina-nanoparticles-on-the-microstructure-strength-and-wear-resistance-of-poly-methyl-methacrylate-based-nanocomposites-prepared-by-friction-stir-processing
#15
Hamed Aghajani Derazkola, Abdolreza Simchi
In this study, alumina-reinforced poly(methyl methacrylate) nanocomposites (PMMA/Al2O3) containing up to 20vol% nanoparticles with an average diameter of 50nm were prepared by friction stir processing. The effects of nanoparticle volume fraction on the microstructural features and mechanical properties of PMMA were studied. It is shown that by using a frustum pin tool and employing an appropriate processing condition, i.e. a rotational speed of 1600rpm/min and transverse velocity of 120mm/min, defect free nanocomposites at microscale with fine distribution of the nanoparticles can successfully been prepared...
January 10, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29334582/carbohydrate-mouth-rinsing-does-not-prevent-the-decline-in-maximal-strength-following-fatiguing-exercise
#16
Christopher D Black, Daniel J Schubert, Marcin K Szczyglowski, Joshua D Wren
Carbohydrate (CHO) rinsing has been shown to attenuate the decline of maximal voluntary contractions (MVC) following fatiguing exercise-perhaps via a central mechanism. This study sought to determine the effect of a CHO rinse on MVC, voluntary activation, and contractile properties following fatiguing exercise. Thirteen adults participated in a double-blind, cross-over study. MVC of the dominant knee extensors was assessed and voluntary activation (%VA) was determined using twitch-interpolation. Participants then held 50% of MVC until volitional fatigue followed by a 20s rinse with a solution of 8% maltodextrin (CHO) or placebo (PLA)...
January 12, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29333787/detection-of-ureaplasma-species-by-a-semi-quantitative-pcr-test-in-urine-samples-can-it-predict-clinical-significance
#17
Merav Strauss, Raul Colodner, Dana Sagas, Azmi Adawi, Hanna Edelstein, Bibiana Chazan
BACKGROUND: Ureaplasma species (Usp) are the most prevalent genital Mycoplasma isolated from the urogenital tract of both men and women. Usp may be commensals in the genital tract but may also be contributors to a number of pathological conditions of the genital tract. Because they can also just colonize the genital tract of healthy people, their pathogenic role can be difficult to prove. OBJECTIVES: The aim of the study was to evaluate the efficacy of a quantitative polymerase chain reaction (qPCR) method for the discrimination between infection and colonization by measuring prevalence of Usp in asymptomatic versus symptomatic patients...
January 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29333772/-effect-of-different-surface-processes-on-the-bond-strength-between-zirconia-framework-and-veneering-ceramic
#18
Gong Qi, Sun Huiqiang, Hu Yijun, Chen Jia, Ding Weishan
OBJECTIVE: To compare the effect of different surface processes on bond strength and microscopic structure using a scanning electron microscope (SEM) and an energy distribution spectrum (EDS) at the bonding interface between zirconia framework and veneering ceramic. METHODS: WIELAND zirconia core material was cut into 33 rectangular specimens and fired on into rectangular specimens (10 mm×5 mm×5 mm). The specimens were randomly divided into three groups (n=
11)...
December 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/29333278/clinical-influence-of-exercise-therapy-on-sarcopenia-in-patients-with-chronic-pancreatitis-a-study-protocol-for-a-randomised-controlled-trial
#19
Kazunori Yoh, Hiroki Nishikawa, Hirayuki Enomoto, Yoshinori Iwata, Akio Ishii, Yukihisa Yuri, Noriko Ishii, Yuho Miyamoto, Kunihiro Hasegawa, Chikage Nakano, Ryo Takata, Takashi Nishimura, Nobuhiro Aizawa, Yoshiyuki Sakai, Naoto Ikeda, Tomoyuki Takashima, Hiroko Iijima, Shuhei Nishiguchi
Introduction and purpose: Chronic pancreatitis (CP) involves progressive inflammatory changes to the pancreas and can lead to permanent structural damage and impairment of both endocrine and exocrine functions. Current reports highlight a rise in the incidence and prevalence of CP. However, there is limited data currently available concerning patients with CP undergoing exercise therapy (ET). We aim to prospectively examine the influence of ET on sarcopenia in patients with CP. Methods and analysis: A detailed evaluation of the nutritional condition and the daily physical activities of each participant will be conducted prior to entering the study...
2018: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29332524/exploring-the-moderating-role-of-problematic-substance-use-in-the-relations-between-borderline-and-antisocial-personality-features-and-intimate-partner-violence
#20
Nicholas A Armenti, Alexandra L Snead, Julia C Babcock
Borderline and antisocial personality features relate to multiple externalizing behaviors, including intimate partner violence (IPV). However, not all individuals with borderline and antisocial traits perpetrate IPV. The strength of the personality-IPV link may be related to problematic substance use. We examined borderline and antisocial personality features, problematic substance use, and IPV in a community sample of couples. Positive relations between both borderline and antisocial features and IPV were stronger in conditions of high problematic alcohol use relative to low problematic alcohol use...
February 2018: Violence Against Women
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