Scheila Iria Kraus, Jeane Bachi Ferreira, Angela Patricia França, Vinícius Alexandre Wippel, Rodrigo Bainy Leal, Raquel Oppermann, Michele Debiasi Alberton, Morgana Duarte da Silva
Fibromyalgia (FM) is a painful chronic condition that significantly impacts the quality of life, posing challenges for clinical management. Given the difficulty of understanding the pathophysiology and finding new therapeutics, this study explored the effects of a medicinal plant, E. brasiliensis, in an FM model induced by reserpine in Swiss mice. Animals were treated with saline 0.9% (vehicle), duloxetine 10 mg/kg (positive control), or hydroalcoholic extract of E. brasiliensis leaves 300 mg/kg (HEEb). Nociceptive parameters, as well as locomotion, motor coordination, strength, anxiety, and depressive-like behaviors, were evaluated for 10 days...
April 19, 2024: Molecular Neurobiology