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https://www.readbyqxmd.com/read/28087919/presumptive-spontaneous-lysosomal-storage-like-disease-in-a-crl-cd1-icr-mouse
#1
Krista M
A clinically unremarkable 4.5-mo-old female Crl:CD1(ICR) VAF/Elite mouse was euthanized for scheduled sentinel processing.Gross necropsy findings included significant hepatosplenomegaly and visceral lymphadenomegaly, resulting in a preliminarygross diagnosis of lymphoma. Histology revealed florid accumulations of large, 'foamy' macrophages present in the bone marrow, small intestines, and viscera including liver, spleen, lymph nodes, thymus, uterus, and ovaries. The cytoplasm of these cells was abundant, stained pale blue with Wright-Giemsa and was periodic acid-Schiff positive...
January 13, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28081555/new-zealand-rugby-health-study-motor-cortex-excitability-in-retired-elite-and-community-level-rugby-players
#2
Gwyn N Lewis, Patria A Hume, Verna Stavric, Scott R Brown, Denise Taylor
AIMS: Rugby union is a high contact sport in which players frequently experience brain injuries. Acute brain injury is associated with altered corticomotor function. However, it is uncertain if long-term exposure to rugby is associated with any alterations in corticomotor function. The aim of the study was to assess measures of corticomotor excitability and inhibition in retired rugby players in comparison to retired non-contact sport players. METHODS: The design was a cross-sectional study with three groups of retired athletes: elite rugby (n=23), community level rugby (n=28) and non-contact sport control (n=22)...
January 13, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28081280/evaluation-on-the-germplasm-of-maize-zea-mays-l-landraces-from-southwest-china
#3
F B Chen, Q L Yao, H F Liu, P Fang
Because of their local adaptation and economic factors that limit the adoption of commercial hybrids, farmer-saved maize landraces are still grown over a considerable area concentrated in southwest China. To evaluate the potential of using maize landraces, the germplasm characteristics of 96 landraces from southwest China were evaluated at phenotypic, cellular, and molecular levels. The existence of high phenotypic variation and elite germplasm tolerant to low-N, low-P, as well as drought stress was observed...
December 23, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28081034/the-effects-of-the-removal-of-electronic-devices-for-48-hours-on-sleep-in-elite-judo-athletes
#4
Ian C Dunican, David T Martin, Shona L Halson, Reid Reale, Brian Dawson, John Caldwell, Maddison J Jones, Peter R Eastwood
OBJECTIVE: This study examined the effects of the removal of electronic devices (i.e., smartphones, etc.) for 48 hours on sleep quality and next-day athletic and cognitive performance in elite Judo athletes. PARTICIPANTS: Over 6 days and nights, 23 eliteAustralian Judo athletes were monitored while attending a camp at the Australian Institute of Sport (AIS). In 14 athletes all electronic devices were removed on days 3 & 4 (i.e. for 48 hours: the 'device-restricted group') while 9 were permitted to use their devices throughout the camp (the 'control group')...
January 4, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28081033/performance-aspects-and-physiological-responses-in-male-amateur-boxing-competitions-a-brief-review
#5
Maamer Slimani, Helmi Chaabène, Philip Davis, Emerson Franchini, Karim Chamari
Boxing is one of the most popular striking combat sports in the world. The aim of this review was to present data concerning performance analysis (time-motion and technical/tactical analysis) and physiological responses (i.e., blood lactate concentration [BLC], heart rate and/or oxygen consumption) during novice and elite male simulated and official amateur boxing competitions in any age category. The present review shows that boxing competition is a high-intensity intermittent striking combat sport. Typically, the activity-to-rest ratio was higher in elite (18:1) than novice (9:1) boxers and significant differences were observed between rounds (1 round=16:1, 2 round=8:1, and 3 round=6:1) in novice boxers...
January 4, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28079705/prescribed-drinking-leads-to-better-cycling-performance-than-ad-libitum-drinking
#6
Costas N Bardis, Stavros A Kavouras, J D Adams, Nickos D Geladas, Demosthenis B Panagiotakos, Labros S Sidossis
: Drinking ad libitum during exercise often leads to dehydration ranging from -1 to -3% of body weight. PURPOSE: To study the effect of a prescribed hydration protocol matching fluid losses on a simulated 30-km criterium-like cycling performance in the heat (31.6±0.5 °C). METHOD: Ten elite, heat-acclimatized, male endurance cyclists (30±5 y, 76.5±7.2 kg, 1.81±0.07 m, VO2peak: 61.3±5.2 ml[BULLET OPERATOR]min[BULLET OPERATOR]kg, body fat: 10...
January 10, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28078945/influences-of-population-size-and-density-on-birthplace-effects
#7
David J Hancock, Patrícia Coutinho, Jean Côté, Isabel Mesquita
Contextual influences on talent development (e.g., birthplace effects) have become a topic of interest for sport scientists. Birthplace effects occur when being born in a certain city size leads to participation or performance advantages, typically for those born in smaller or mid-sized cities. The purpose of this study was to investigate birthplace effects in Portuguese volleyball players by analysing city size, as well as population density - an important but infrequently used variable. Participants included 4062 volleyball players (Mage = 33), 53...
January 12, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28078817/birth-of-puppies-of-predetermined-sex-after-artificial-insemination-with-a-low-number-of-sex-sorted-frozen-thawed-spermatozoa-in-field-conditions
#8
Yun-Fang Wei, Fang-Liang Chen, Shu-Sheng Tang, Ai-Guo Mao, Li-Guang Li, Lu-Guang Cheng, Chao Chen, Fei-Xiang Li, Bin Wang, Tao Xu, Yue-Jun Zhang, Jing Li, Jiu-Sheng Wan
The aim of this study was to evaluate fertility and sex ratios after artificial insemination in dogs under field conditions. Semen was cryopreserved as unsorted (control) or was separated into X- and Y-chromosome-bearing sperm using a cell sorter. Sixty female dogs were inseminated with frozen-thawed spermatozoa of 100 × 10(6) unsorted (a dose in practice) and 4 × 10(6) sorted (X and Y group, respectively). A total of 20 dogs became pregnant and 126 puppies were born from the three groups. The percentage of parturition was similar for the X (5/20; 25...
January 11, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28077649/tcr-clonotype-specific-differences-in-inhibitory-activity-of-hiv-1-cytotoxic-t-cell-clones-is-not-mediated-by-tcr-alone
#9
Nina C Flerin, Huabiao Chen, Tynisha D Glover, Pedro A Lamothe, Jian Hua Zheng, Justin W Fang, Zaza M Ndhlovu, Evan W Newell, Mark M Davis, Bruce D Walker, Harris Goldstein
: Functional analysis of T cell responses in HIV-infected individuals has indicated that virus-specific CD8(+) T cells with superior antiviral efficacy are well represented in HIV-1 controllers but are rare or absent in HIV-1 progessors. To define the role of individual TCR clonotypes in differential antiviral CD8(+) T cell function, we performed detailed functional and mass cytometric cluster analysis of multiple CD8(+) T cell clones recognizing the identical HLA-B*2705-restricted HIV-1 epitope KK10 (KRWIILGLNK)...
January 11, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28076395/mapping-and-genetic-structure-analysis-of-the-anthracnose-resistance-locus-co-1hy-in-the-common-bean-phaseolus-vulgaris-l
#10
Mingli Chen, Jing Wu, Lanfen Wang, Nitin Mantri, Xiaoyan Zhang, Zhendong Zhu, Shumin Wang
Anthracnose is a destructive disease of the common bean (Phaseolus vulgaris L.). The Andean cultivar Hongyundou has been demonstrated to possess strong resistance to anthracnose race 81. To study the genetics of this resistance, the Hongyundou cultivar was crossed with a susceptible genotype Jingdou. Segregation of resistance for race 81 was assessed in the F2 population and F2:3 lines under controlled conditions. Results indicate that Hongyundou carries a single dominant gene for anthracnose resistance. An allele test by crossing Hongyundou with another resistant cultivar revealed that the resistance gene is in the Co-1 locus (therefore named Co-1HY)...
2017: PloS One
https://www.readbyqxmd.com/read/28072594/genetics-consultation-rates-following-a-diagnosis-of-high-grade-serous-ovarian-carcinoma-in-the-canadian-province-of-ontario
#11
Jacob McGee, Karen Panabaker, Sean Leonard, Peter Ainsworth, Laurie Elit, Salimah Z Shariff
OBJECTIVE: In 2001, the province of Ontario expanded cancer genetic testing eligibility to include all women with high-grade serous ovarian carcinoma (HGSC) of the ovary, fallopian tube, and peritoneum. The aim of this study was to determine the proportion of women who attended genetics counseling for consideration of BRCA1/2 gene analysis. We also sought to examine if regional differences in consultation rate exist across administrative health regions in the province of Ontario. METHODS: We identified all women with a pathological diagnosis of HGSC in the province of Ontario between 1997 until 2011...
January 9, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28069446/rich2-is-implicated-in-viraemic-control-of-hiv-1-in-black-south-african-individuals
#12
Maria Paximadis, Refilwe N Ngqobe, Richard E Chaisson, Neil A Martinson, Caroline T Tiemessen
An intronic single nucleotide polymorphism (SNP) in RICH2 (rs2072255; 255(i)), in complete linkage disequilibrium (LD) with an exonic SNP (rs2072254; 254(e)), has been identified in a genome wide association study to be associated with progression to AIDS in Caucasian individuals. RICH2 links tetherin to the cortical actin network and the RICH2/tetherin interaction has been shown to be important for the downstream activation of NF-κβ and the consequential promotion of proinflammatory responses. We investigated the role of these two SNPs in natural control of HIV-1 in black South Africans including healthy controls (HCs; N=102) and antiretroviral-naive HIV-1-infected controllers (HICs; N=52) and progressors (N=74)...
January 6, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28068210/how-players-exploit-variability-and-regularity-of-game-actions-in-female-volleyball-teams
#13
Ana Ramos, Patrícia Coutinho, Pedro Silva, Keith Davids, Isabel Mesquita
Variability analysis has been used to understand how competitive constraints shape different behaviours in team sports. In this study, we analysed and compared variability of tactical performance indices in players within complex I at two different competitive levels in volleyball. We also examined whether variability was influenced by set type and period. Eight matches from the 2012 Olympics competition and from the Portuguese national league in the 2014-2015 season were analysed (1496 rallies). Variability of setting conditions, attack zone, attack tempo and block opposition was assessed using Shannon entropy measures...
January 9, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28065994/injuries-in-elite-taekwondo-poomsae-athletes
#14
Mohsen Kazemi, Anas Ingar, Ali Jaffery
Poomsae is the only non-contact and no opponent form of Taekwondo. The purpose of this descriptive study was to determine the type and rate of injuries in elite Canadian Poomsae athletes. Strain and joint dysfunction were the most common types of injuries in Poomsae. Lower limb and back were the most common area of injury in females and males respectively. Females with a lower rank in experience level (DAN≤ 3) were more likely to suffer from chronic overuse injuries compared to their male counterparts, who reported more acute injuries...
December 2016: Journal of the Canadian Chiropractic Association
https://www.readbyqxmd.com/read/28065583/left-ventricular-contraction-pattern-in-chronic-aortic-regurgitation-and-preserved-ejection-fraction-simultaneous-stress-strain-analysis-by-three-dimensional-echocardiography
#15
Kaspar Broch, Stefano F de Marchi, Richard Massey, Jonny Hisdal, Svend Aakhus, Lars Gullestad, Stig Urheim
BACKGROUND: The role of speckle-tracking echocardiography in the assessment of chronic aortic regurgitation (AR) is not established. Load dependency may encumber the interpretation of strain measurements in the chronically overloaded left ventricle. The aim of this study was to investigate the mechanisms of left ventricular (LV) contraction patterns in asymptomatic patients with moderate to severe AR and preserved ejection fractions. METHODS: In this prospective, cross-sectional study, 31 patients with moderate to severe AR, 15 elite endurance athletes, and 17 healthy control subjects were examined using three-dimensional speckle-tracking echocardiography...
January 5, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28065448/left-ventricular-dyssynchrony-and-2d-and-3d-global-longitudinal-strain-for-differentiating-physiological-and-pathological-left-ventricular-hypertrophy
#16
Julien Ternacle, Camille Bremont, Thomas d'Humieres, Laureline Faivre, Huy Long Doan, Romain Gallet, Leopold Oliver, Jean-Luc Dubois-Randé, Pascal Lim
BACKGROUND: Diagnosis of hypertrophic cardiomyopathy (HCM) in athletes can be challenging. AIMS: To ascertain parameters that differentiate patients with HCM from athletes with moderate left ventricular (LV) hypertrophy (LVH 13-15mm). METHODS: We retrospectively included 100 men: 50 elite rugby players (25 with moderate LVH and 25 with no LVH), 25 patients with HCM and moderate LVH and 25 controls. LV dyssynchrony was defined as the standard deviation of time to peak 2D longitudinal strain (16-segment model) and global strain components were computed from two- (2D) and three-dimensional (3D) speckle tracking...
January 3, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/28063098/muscular-body-build-and-male-sex-are-independently-associated-with-malignant-hyperthermia-susceptibility
#17
Brian Butala, Barbara Brandom
PURPOSE: Malignant hyperthermia susceptibility (MHS) is a disorder of the regulation of calcium in skeletal muscle. Muscular individuals have been shown to have a 13.6-fold increased risk of death during malignant hyperthermia (MH) episodes and are more likely to experience a recurrence after initial treatment. Twenty-five percent of severe MH episodes have occurred in elite athletes. This study investigated the association between MHS and muscular body build. METHODS: Data were obtained from existing reports in the North American Malignant Hyperthermia Registry, including the Report of Muscle Biopsy and Contracture Testing (caffeine-halothane contracture test [CHCT]) as well as Adverse Metabolic or Muscular Reaction to Anesthesia (AMRA) reports...
January 6, 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/28062019/care-delivery-patterns-processes-and-outcomes-for-primary-ovarian-cancer-surgery-a-population-based-review-using-a-national-administrative-database
#18
Saad Shakeel, Laurie Elit, Noori Akhtar-Danesh, Laura Schneider, Christian Finley
OBJECTIVES: In this pan-Canadian study, we sought to elucidate the current state of surgical care for primary ovarian cancers and factors influencing selected short-term outcomes; these were in-hospital mortality (IHM), major complications (MCs), failure-to-rescue (FTR), and hospital length of stay (LOS). METHODS: We created a population cohort using inpatient admission records from the Canadian Institute of Health Information data set (2004-2012). Multilevel logistic regression and flexible parametric survival analyses, adjusted for hospital clustering effect, were conducted to determine the effect of patient-specific factors (i...
January 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28060015/ifn-%C3%AE-augments-nk-mediated-antibody-dependent-cellular-cytotoxicity-adcc-of-hiv-1-infected-autologous-cd4-t-cells-regardless-of-mhc-i-downregulation
#19
Costin Tomescu, Pablo Tebas, Luis J Montaner
DESIGN: We have previously shown that IFN-α stimulation augments direct NK cell lysis of autologous CD4 primary T cells infected with certain HIV-1 isolates based upon MHC-I downregulation capacity. Here, we investigated if Antibody Dependent Cellular Cytotoxicity (ADCC) could trigger lysis of HIV-1 isolates that were resistant to direct NK lysis and if IFN-α pre-stimulation of NK cells could further enhance ADCC. METHODS: Using broadly neutralizing monoclonal antibodies against gp120 (VRC01 or PGV04) or plasma from HIV-1 infected subjects (ART-suppressed or Elite Controller) to trigger ADCC, we measured NK cell chromium release cytotoxicity against HIV-1 infected autologous CD4 primary T cells and NK cell CD107a degranulation against gp120-coated CD4 T cells...
January 4, 2017: AIDS
https://www.readbyqxmd.com/read/28056792/elucidation-of-the-molecular-responses-of-a-cucumber-segment-substitution-line-carrying-pm5-1-and-its-recurrent-parent-triggered-by-powdery-mildew-by-comparative-transcriptome-profiling
#20
Qiang Xu, Xuewen Xu, Yang Shi, Xiaohua Qi, Xuehao Chen
BACKGROUND: Powdery mildew (PM) is one of the most severe fungal diseases of cucurbits, but the molecular mechanisms underlying PM resistance in cucumber remain elusive. In this study, we developed a PM resistant segment substitution line SSL508-28 that carried a segment on chromosome five representing the Pm5.1 locus from PM resistant donor Jin5-508 using marker-assisted backcrossing of an elite PM susceptible cucumber inbred line D8. RESULTS: Whole-genome resequencing of SSL508-28, Jin5-508 and D8 was performed to identify the exact boundaries of the breakpoints for this introgression because of the low density of available single sequence repeat markers...
January 5, 2017: BMC Genomics
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