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https://www.readbyqxmd.com/read/29166588/regulatory-t-cell-migration-is-dependent-on-glucokinase-mediated-glycolysis
#1
Madhav Kishore, Kenneth C P Cheung, Hongmei Fu, Fabrizia Bonacina, Guosu Wang, David Coe, Eleanor J Ward, Alessandra Colamatteo, Maryam Jangani, Andrea Baragetti, Giuseppe Matarese, David M Smith, Robert Haas, Claudio Mauro, David C Wraith, Klaus Okkenhaug, Alberico L Catapano, Veronica De Rosa, Giuseppe D Norata, Federica M Marelli-Berg
Migration of activated regulatory T (Treg) cells to inflamed tissue is crucial for their immune-modulatory function. While metabolic reprogramming during Treg cell differentiation has been extensively studied, the bioenergetics of Treg cell trafficking remains undefined. We have investigated the metabolic demands of migrating Treg cells in vitro and in vivo. We show that glycolysis was instrumental for their migration and was initiated by pro-migratory stimuli via a PI3K-mTORC2-mediated pathway culminating in induction of the enzyme glucokinase (GCK)...
November 21, 2017: Immunity
https://www.readbyqxmd.com/read/29166575/chemical-characterization-and-pharmacological-assessment-of-cashew-gum-extract-anacardium-occidentale-l-polysaccharide-free
#2
Daiany Priscilla Bueno da Silva, Iziara Ferreira Florentino, Lorrane Kelle da Silva Moreira, Adriane Ferreira Brito, Verônica Vale Carvalho, Géssica Adriana Vasconcelos, Boniek Gontijo Vaz, Marcus Antônio Pereira-Junior, Kátia Flávia Fernandes, Elson Alves Costa
ETHNOPHARMACOLOGICAL RELEVANCE: The cashew gum (Anacardium occidentale L.) is used in Brazilian traditional medicine in the treatment of inflammatory conditions, asthma, diabetes, and gastrointestinal disturbs. AIM OF THE STUDY: The present study was aimed the chemical characterization and the investigation of the antinociceptive and anti-inflammatory activities of cashew gum aqueous extract without the presence of polysaccharides in its composition (CGE). MATERIALS AND METHODS: The CGE was obtained after precipitation and removal of polysaccharides using acetone...
November 19, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29166439/the-geographic-information-system-applied-to-study-schistosomiasis-in-pernambuco
#3
Verônica Santos Barbosa, Rodrigo Moraes Loyo, Ricardo José de Paula Souza E Guimarães, Constança Simões Barbosa
OBJECTIVE: Diagnose risk environments for schistosomiasis in coastal localities of Pernambuco using geoprocessing techniques. METHODS: A coproscopic and malacological survey were carried out in the Forte Orange and Serrambi areas. Environmental variables (temperature, salinity, pH, total dissolved solids and water fecal coliform dosage) were collected from Biomphalaria breeding sites or foci. The spatial analysis was performed using ArcGis 10.1 software, applying the kernel estimator, elevation map, and distance map...
2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29166419/combined-stereophotogrammetry-and-laser-sintered-computer-aided-milling-framework-for-an-implant-supported-mandibular-prosthesis-a-case-history-report
#4
Maria J Suarez, Iria Paisal, Veronica Rodriguez-Alonso, Carlos Lopez-Suarez
PURPOSE: This study compared the marginal gaps of computer-aided design/computer-aided manufacture (CAD/CAM)-fabricated all-ceramic crowns constructed from scanned impressions and models and with two different occlusal reduction designs. MATERIALS AND METHODS: Two typodont mandibular first molars were prepared to receive CAD/CAM-fabricated all-ceramic crowns. Both molars were prepared to ideal crown reduction, the first with anatomical occlusal reduction (AOR) and the second with completely flat occlusal reduction (FOR)...
November 22, 2017: International Journal of Prosthodontics
https://www.readbyqxmd.com/read/29165784/interventions-for-managing-skeletal-muscle-spasticity-following-traumatic-brain-injury
#5
REVIEW
Anneliese Synnot, Marisa Chau, Veronica Pitt, Denise O'Connor, Russell L Gruen, Jason Wasiak, Ornella Clavisi, Loyal Pattuwage, Kate Phillips
BACKGROUND: Skeletal muscle spasticity is a major physical complication resulting from traumatic brain injury (TBI), which can lead to muscle contracture, joint stiffness, reduced range of movement, broken skin and pain. Treatments for spasticity include a range of pharmacological and non-pharmacological interventions, often used in combination. Management of spasticity following TBI varies from other clinical populations because of the added complexity of behavioural and cognitive issues associated with TBI...
November 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29165474/sugar-and-mineral-enriched-fraction-from-olive-mill-wastewater-for-promising-cosmeceutical-application-characterization-in-vitro-and-in-vivo-studies
#6
Maria Domenica Di Mauro, Barbara Tomasello, Roberta Carla Giardina, Sandro Dattilo, Veronica Mazzei, Fulvia Sinatra, Massimo Caruso, Nicola D'Antona, Marcella Renis
Nowadays, agro-food by-products represent a potential low-cost source of biologically active ingredients which have been paid significant attention as nutraceuticals, medicine, food and cosmetics. In a previous study we evaluated the total sugars, metals and polyphenols of olive mill wastewater (OMWW) from a Cerasuola olive cultivar. In the present work we selectively recovered a sugar and mineral enriched fraction (SMEF) from Cerasuola OMWW by a green adsorption/desorption process. The SMEF was mainly found to be composed of monosaccharides and potassium by HPLC-ELSD and ICP-MS...
November 22, 2017: Food & Function
https://www.readbyqxmd.com/read/29165000/building-better-caregivers-a-pragmatic-12-month-trial-of-a-community-based-workshop-for-caregivers-of-cognitively-impaired-adults
#7
Kate Lorig, Philip L Ritter, Diana D Laurent, Veronica Yank
Building Better Caregivers (BBC), a community 6-week, peer-led intervention, targets family caregivers of those with cognitive impairments. BBC was implemented in four geographically scattered areas. Self-report data were collected at baseline, 6 months, and 1 year. Primary outcome were caregiver strain and depression. Secondary outcomes included caregiver burden, stress, fatigue, pain, sleep, self-rated health, exercise, self-efficacy, and caregiver and care partner health care utilization. Paired t tests examined 6 month and 1-year improvements...
November 1, 2017: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
https://www.readbyqxmd.com/read/29164811/congenital-heart-defects-in-ivf-icsi-pregnancy-a-systematic-review-and-meta-analysis
#8
REVIEW
Veronica Giorgione, Fabio Parazzini, Vlasta Fesslova, Sonia Cipriani, Massimo Candiani, Annalisa Inversetti, Cristina Sigismondi, Francesca Tiberio, Paolo Cavoretto
OBJECTIVE: There is no consensus in current practice guidelines whether IVF/ICSI conception represents an indication for performing a fetal echocardiogram. The aim of the study is to assess whether CHD occurs more often with the use of in-vitro-fertilization (IVF)/ intracytoplasmic sperm injection (ICSI) techniques as compared to spontaneous pregnancies. METHODS: A systematic search for studies in PubMed/MEDLINE, Embase and Scopus from inception to September 2017 was conducted...
November 22, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29164678/speckled-acral-hypopigmentation-in-an-adolescent
#9
Veronica L Rutt, Kelly B Quinn, Andrea Zaenglein
We report a case of speckled acral hypopigmentation in a 12-year-old girl. She presented with asymptomatic hypopigmented macules on the hands and feet. This rare entity is a proposed variant of reticulate acropigmentation and of unknown etiology.
November 21, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29163752/cytotoxicity-oxidative-stress-cell-cycle-arrest-and-mitochondrial-apoptosis-after-combined-treatment-of-hepatocarcinoma-cells-with-maleic-anhydride-derivatives-and-quercetin
#10
Gabriela Carrasco-Torres, Rafael Baltiérrez-Hoyos, Erik Andrade-Jorge, Saúl Villa-Treviño, José Guadalupe Trujillo-Ferrara, Verónica Rocío Vásquez-Garzón
The inflammatory condition of malignant tumors continually exposes cancer cells to reactive oxygen species, an oxidizing condition that leads to the activation of the antioxidant defense system. A similar activation occurs with glutathione production. This oxidant condition enables tumor cells to maintain the energy required for growth, proliferation, and evasion of cell death. The objective of the present study was to determine the effect on hepatocellular carcinoma cells of a combination treatment with maleic anhydride derivatives (prooxidants) and quercetin (an antioxidant)...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29162693/%C3%AE-np63-mediated-regulation-of-hyaluronic-acid-metabolism-and-signaling-supports-hnscc-tumorigenesis
#11
Mirco Compagnone, Veronica Gatti, Dario Presutti, Giovina Ruberti, Claudia Fierro, Elke Katrin Markert, Karen H Vousden, Huiqing Zhou, Alessandro Mauriello, Lucia Anemone, Lucilla Bongiorno-Borbone, Gerry Melino, Angelo Peschiaroli
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, and several molecular pathways that underlie the molecular tumorigenesis of HNSCC have been identified. Among them, amplification or overexpression of ΔNp63 isoforms is observed in the majority of HNSCCs. Here, we unveiled a ΔNp63-dependent transcriptional program able to regulate the metabolism and the signaling of hyaluronic acid (HA), the major component of the extracellular matrix (ECM). We found that ∆Np63 is capable of sustaining the production of HA levels in cell culture and in vivo by regulating the expression of the HA synthase HAS3 and two hyaluronidase genes, HYAL-1 and HYAL-3...
November 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29162552/the-challenge-of-species-delimitation-in-the-diploid-polyploid-complex-veronica-subsection-pentasepalae
#12
Nélida Padilla-García, Blanca M Rojas-Andrés, Noemí López-González, Mariana Castro, Sílvia Castro, João Loureiro, Dirk C Albach, Nathalie Machon, M Montserrat Martínez-Ortega
A reliable taxonomic framework and the identification of evolutionary lineages are essential for effective decisions in conservation biodiversity programs. However, phylogenetic reconstruction becomes extremely difficult when polyploidy and hybridization are involved. Veronica subsection Pentasepalae is a diploid-polyploid complex of ca. 20 species with ploidy levels ranging from 2x to 10x. Here, DNA-ploidy level estimations and AFLP fingerprinting were used to determine the evolutionary history, and species boundaries were reviewed in an integrated approach including also previous data (mainly morphology and sequence-based phylogenetic reconstructions)...
November 18, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/29162248/predicting-syndesmotic-injuries-in-ankle-fractures-a-new-system-based-on-the-medial-malleolar-focus
#13
Enrique Sánchez-Morata, José Carlos Martínez-Ávila, Elena Vacas Sánchez, Verónica Jiménez Díaz, Jaime Zorrilla Sánchez de Neyra, Jesús Vilá Y Rico
The early establishment of the diagnosis of a syndesmotic injury is essential for treatment selection. However, such injuries may not be apparent radiographically. Previous studies have attempted to describe correlations between medial malleolar fracture geometry and syndesmotic disruption. The main objective of this study was to create predictive models for assessing syndesmotic injuries based on an originally described angle, i.e., the medial crural-focal angle (MCFA). This study included 138 ankle fractures involving the medial malleolus...
November 2017: Injury
https://www.readbyqxmd.com/read/29160409/association-between-postural-balance-and-anthropometric-indexes-in-elementary-schoolchildren
#14
Simone Lara, Susane Graup, Rodrigo de Souza Balk, Lilian Pinto Teixeira, Ariane Dias Farias, Giselle Baioco Alves, Verônica Benachio Leiria
OBJECTIVE: To analyze the association between postural balance and anthropometric indicators in elementary school students. METHODS: This cross-sectional, descriptive and quantitative study included children enrolled in the first year of elementary school, of both sexes, in the age group of 6 to 7 years. Children with any physical or cognitive impairment, children who did not participate in all stages of the study evaluation, or those who failed to perform postural balance assessments were excluded...
November 13, 2017: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
https://www.readbyqxmd.com/read/29160086/anatomic-and-radiologic-study-of-renal-avascular-plane-brodel-s-line-and-its-potential-relevance-on-percutaneous-and-surgical-approaches-to-the-kidney
#15
Veronica Macchi, Edgardo Picardi, Antonino Inferrera, Andrea Porzionato, Alessandro Crestani, Giacomo Novara, Raffaele De Caro, Vincenzo Ficarra
OBJECTIVE: The aim of the present anatomic and radiologic study was to evaluate the location, extension and characteristics of the Brödel's plane and eventually define its different patterns. MATERIAL AND METHODS: We evaluated 15 human normal kidneys sampled from un-embalmed cadavers without clinical history or anatomical evidence of renal diseases. Kidneys with the surrounding perirenal fat tissue were removed en bloc with the abdominal segment of the aorta. The renal artery was injected with acrylic and radiopaque resins...
November 21, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/29159853/the-use-of-cell-conditioned-medium-for-musculoskeletal-tissue-regeneration
#16
REVIEW
Francesca Veronesi, Veronica Borsari, Maria Sartori, Monia Orciani, Monica Mattioli-Belmonte Cima, Milena Fini
Tissue regenerative medicine combines the use of cells, scaffolds and molecules to repair damaged tissues. Different cell types are employed for musculoskeletal diseases, both differentiated and mesenchymal stromal cells (MSCs). In recent years, the hypothesis that cell-based therapy is guided principally by cell-secreted factors has become increasingly popular. The aim of the present literature review was to evaluate preclinical and clinical studies that used conditioned medium (CM), rich in cell-factors, for musculoskeletal regeneration with a cell-free approach...
November 20, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29158938/orthodeoxia-without-platypnea-in-hereditary-hemorrhagic-telangiectasia-in-the-presence-of-a-cerebral-abscess-and-multiple-pulmonary-arteriovenous-malformations-unusual-complications-and-transcatheter-endovascular-treatment
#17
Carlos Salazar, Jacky Bruce Blank, Veronica Palmero
Hereditary hemorrhagic telangiectasia is a rare autosomal-dominant condition affecting visceral blood vessel development. Cerebral and most commonly pulmonary arteriovenous malformations are found in the majority of symptomatic patients. The most common complications include embolic strokes and cerebral abscesses, which have been attributed to abnormal vessel communications. Platypnea orthodeoxia is a rare condition that presents dyspnea and oxygen desaturation when adopting an upright position and is relieved on decubitus...
2017: Case Reports in Pulmonology
https://www.readbyqxmd.com/read/29157748/consensus-contouring-guidelines-for-postoperative-completely-resected-cavity-stereotactic-radiosurgery-for-brain-metastases
#18
Hany Soliman, Mark Ruschin, Lilyana Angelov, Paul D Brown, Veronica L S Chiang, John P Kirkpatrick, Simon S Lo, Anita Mahajan, Kevin S Oh, Jason P Sheehan, Scott G Soltys, Arjun Sahgal
PURPOSE: To propose contouring guidelines based on consensus contours generated by 10 international experts for cavity stereotactic radiosurgery (SRS), an emerging treatment option after surgical resection of brain metastases. No guidelines for contouring the surgical cavity volume have been previously reported. METHODS AND MATERIALS: Ten postoperative completely resected cases with varying clinical scenarios and locations within the brain were selected. For each case, 10 experts independently contoured the surgical cavity clinical target volume (CTV)...
October 4, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29157291/vaccination-with-recombinant-adenovirus-expressing-peste-des-petits-ruminants-virus-f-or-h-proteins-elicits-t-cell-responses-to-epitopes-that-arises-during-pprv-infection
#19
José Manuel Rojas, Miguel Avia, Elena Pascual, Noemí Sevilla, Verónica Martín
Peste des petits ruminants virus (PPRV) causes an economically important disease that limits productivity in small domestic ruminants and often affects the livestock of the poorest populations in developing countries. Animals that survive PPRV develop strong cellular and humoral responses, which are probably necessary for protection. Vaccination should thus aim at mimicking these natural responses. Immunization strategies against this morbillivirus using recombinant adenoviruses expressing PPRV-F or -H proteins can protect PPRV-challenged animals and permit differentiation of infected from vaccinated animals...
November 21, 2017: Veterinary Research
https://www.readbyqxmd.com/read/29157232/implementation-of-an-interprofessional-team-based-learning-program-involving-seven-undergraduate-health-and-social-care-programs-from-two-universities-and-students-evaluation-of-their-readiness-for-interprofessional-learning
#20
Lap Ki Chan, Fraide Ganotice, Frances Kam Yuet Wong, Chak Sing Lau, Susan M Bridges, Celia Hoi Yan Chan, Namkiu Chan, Phoebe Wing Lam Chan, Hai Yong Chen, Julie Yun Chen, Jody Kwok Pui Chu, Charlene C Ho, Jacqueline Mei Chi Ho, Tai Pong Lam, Veronica Suk Fun Lam, Qingyun Li, Jian Gang Shen, Julian Alexander Tanner, Winnie Wan Yee Tso, Arkers Kwan Ching Wong, Gordon Tin Chun Wong, Janet Yuen Ha Wong, Nai Sum Wong, Alan Worsley, Lei King Yu, Tin Pui Yum
BACKGROUND: Interprofessional learning is gaining momentum in revolutionizing healthcare education. During the academic year 2015/16, seven undergraduate-entry health and social care programs from two universities in Hong Kong took part in an interprofessional education program. Based on considerations such as the large number of students involved and the need to incorporate adult learning principles, team-based learning was adopted as the pedagogy for the program, which was therefore called the interprofessional team-based learning program (IPTBL)...
November 21, 2017: BMC Medical Education
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