keyword
MENU ▼
Read by QxMD icon Read
search

Wolf

keyword
https://www.readbyqxmd.com/read/28448662/effect-of-neoadjuvant-chemotherapy-followed-by-surgical-resection-on-survival-in-patients-with-limited-metastatic-gastric-or-gastroesophageal-junction-cancer-the-aio-flot3-trial
#1
Salah-Eddin Al-Batran, Nils Homann, Claudia Pauligk, Gerald Illerhaus, Uwe M Martens, Jan Stoehlmacher, Harald Schmalenberg, Kim B Luley, Nicole Prasnikar, Matthias Egger, Stephan Probst, Helmut Messmann, Markus Moehler, Wolfgang Fischbach, Jörg T Hartmann, Frank Mayer, Heinz-Gert Höffkes, Michael Koenigsmann, Dirk Arnold, Thomas W Kraus, Kersten Grimm, Stefan Berkhoff, Stefan Post, Elke Jäger, Wolf Bechstein, Ulrich Ronellenfitsch, Stefan Mönig, Ralf D Hofheinz
Importance: Surgical resection has a potential benefit for patients with metastatic adenocarcinoma of the stomach and gastroesophageal junction. Objective: To evaluate outcome in patients with limited metastatic disease who receive chemotherapy first and proceed to surgical resection. Design, Setting, and Participants: The AIO-FLOT3 (Arbeitsgemeinschaft Internistische Onkologie-fluorouracil, leucovorin, oxaliplatin, and docetaxel) trial is a prospective, phase 2 trial of 252 patients with resectable or metastatic gastric or gastroesophageal junction adenocarcinoma...
April 27, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28447912/targeting-ret-in-patients-with-ret-rearranged-lung-cancers-results-from-the-global-multicenter-ret-registry
#2
Oliver Gautschi, Julie Milia, Thomas Filleron, Juergen Wolf, David P Carbone, Dwight Owen, Ross Camidge, Vignhesh Narayanan, Robert C Doebele, Benjamin Besse, Jordi Remon-Masip, Pasi A Janne, Mark M Awad, Nir Peled, Chul-Cho Byoung, Daniel D Karp, Michael Van Den Heuvel, Heather A Wakelee, Joel W Neal, Tony S K Mok, James C H Yang, Sai-Hong Ignatius Ou, Georg Pall, Patrizia Froesch, Gérard Zalcman, David R Gandara, Jonathan W Riess, Vamsidhar Velcheti, Kristin Zeidler, Joachim Diebold, Martin Früh, Sebastian Michels, Isabelle Monnet, Sanjay Popat, Rafael Rosell, Niki Karachaliou, Sacha I Rothschild, Jin-Yuan Shih, Arne Warth, Thomas Muley, Florian Cabillic, Julien Mazières, Alexander Drilon
Purpose In addition to prospective trials for non-small-cell lung cancers (NSCLCs) that are driven by less common genomic alterations, registries provide complementary information on patient response to targeted therapies. Here, we present the results of an international registry of patients with RET-rearranged NSCLCs, providing the largest data set, to our knowledge, on outcomes of RET-directed therapy thus far. Methods A global, multicenter network of thoracic oncologists identified patients with pathologically confirmed NSCLC that harbored a RET rearrangement...
May 1, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28447298/a-new-species-of-tinrovia-mamaev-1987-monogenea-microcotylidae-from-the-deep-sea-fish-notacanthus-bonaparte-risso-notacanthiformes-notacanthidae-in-the-western-mediterranean-and-the-north-east-atlantic
#3
Wolf Isbert, Maite Carrassón, Ana Pérez-Del-Olmo, Francisco Esteban Montero
A new microcotylid, Tinrovia mamaevi n. sp. (Monogenea: Polyopisthocotylea), is described from the gills of Notacanthus bonaparte Risso (Notacanthiformes: Notacanthidae), sampled in the Western Mediterranean and North East Atlantic. This species is allocated to the subfamily Syncoelicotylinae Mamaev & Zubchenko, 1978 due to the possession of a symmetrical haptor with two separate frills. The clamps in T. mamaevi n. sp. are of the "microcotylid" type, arranged in two distinct lateral haptoral frills; the genital atrium and the copulatory organ are armed and the vaginal pore is unarmed...
April 26, 2017: Systematic Parasitology
https://www.readbyqxmd.com/read/28447239/the-potential-role-of-three-dimensional-surface-imaging-as-a-tool-to-evaluate-aesthetic-outcome-after-breast-conserving-therapy-bct
#4
Rachel L O'Connell, Rosa Di Micco, Komel Khabra, Lisa Wolf, Nandita deSouza, Nicola Roche, Peter A Barry, Anna M Kirby, Jennifer E Rusby
PURPOSE: To establish whether objective measurements of symmetry of volume and shape using three-dimensional surface imaging (3D-SI) can be used as surrogate markers of aesthetic outcome in patients who have undergone breast conserving therapy (BCT). METHODS: Women who had undergone unilateral BCT in the preceding 1-6 years were invited to participate. Participants completed a satisfaction questionnaire (BREAST-Q) and underwent 3D-SI. Volume and surface symmetry were measured on the images...
April 26, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28446704/preservation-of-protein-expression-systems-at-elevated-temperatures-for-portable-therapeutic-production
#5
David K Karig, Seneca Bessling, Peter Thielen, Sherry Zhang, Joshua Wolfe
Many biotechnology capabilities are limited by stringent storage needs of reagents, largely prohibiting use outside of specialized laboratories. Focusing on a large class of protein-based biotechnology applications, we address this issue by developing a method for preserving cell-free protein expression systems for months above room temperature. Our approach realizes unprecedented long-term stability at elevated temperatures by leveraging the sugar alcohol trehalose, a simple, low-cost, open-air drying step, and strategic separation of reaction components during drying...
April 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28446351/deep-vein-thrombosis-of-the-upper-extremity
#6
Jan Heil, Wolfgang Miesbach, Thomas Vogl, Wolf O Bechstein, Alexander Reinisch
BACKGROUND: Deep venous thrombosis (DVT) arises with an incidence of about 1 per 1000 persons per year; 4-10% of all DVTs are located in an upper extremity (DVT-UE). DVT-UE can lead to complications such as post-thrombotic syndrome and pulmonary embolism and carries a high mortality. METHODS: This review is based on pertinent literature, published from January 1980 to May 2016, that was retrieved by a systematic search, employing the PRISMA criteria, carried out in four databases: PubMed (n = 749), EMBASE (n = 789), SciSearch (n = 0), and the Cochrane Library (n = 12)...
April 7, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28446181/a-neuromuscular-electrical-stimulation-nmes-and-robot-hybrid-system-for-multi-joint-coordinated-upper-limb-rehabilitation-after-stroke
#7
Wei Rong, Waiming Li, Mankit Pang, Junyan Hu, Xijun Wei, Bibo Yang, Honwah Wai, Xiaoxiang Zheng, Xiaoling Hu
BACKGROUND: It is a challenge to reduce the muscular discoordination in the paretic upper limb after stroke in the traditional rehabilitation programs. METHOD: In this study, a neuromuscular electrical stimulation (NMES) and robot hybrid system was developed for multi-joint coordinated upper limb physical training. The system could assist the elbow, wrist and fingers to conduct arm reaching out, hand opening/grasping and arm withdrawing by tracking an indicative moving cursor on the screen of a computer, with the support from the joint motors and electrical stimulations on target muscles, under the voluntary intention control by electromyography (EMG)...
April 26, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28445899/evidence-based-guidelines-for-the-pharmacologic-management-of-methamphetamine-dependence-relapse-prevention-chronic-methamphetamine-related-and-comorbid-psychiatric-disorders-in-post-acute-settings
#8
Roland Härtel-Petri, Anne Krampe-Scheidler, Wolf-Dietrich Braunwarth, Ursula Havemann-Reinecke, Peter Jeschke, Winfried Looser, Stephan Mühlig, Ingo Schäfer, Norbert Scherbaum, Lydia Bothe, Corinna Schaefer, Willem Hamdorf
The increasing abuse of the street drug crystal meth (methamphetamine) in many countries worldwide has resulted in a growing demand to treat patients who have acquired a methamphetamine-related disorder. The results of a systematic literature search which led to the consensus-based recommendations by the Working Group of the German Agency for Quality in Medicine (Ärztliches Zentrum für Qualität in der Medizin - ÄZQ) are presented. Pharmacological treatments were reviewed in 58 out of the 103 publications included...
April 26, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28444681/-wolf-hirschhorn-syndrome-description-of-a-spanish-cohort-of-51-cases-and-a-literature-review
#9
R Blanco-Lago, I Malaga-Dieguez, J J Granizo-Martinez, L Carrera-Garcia, P Barruz-Galian, P Lapunzina, J Nevado-Blanco, En Representacion Del Grupo Colaborativo Para El Estudio Del Sindrome de Wolf-Hirschhorn En Representacion Del Grupo Colaborativo Para El Estudio Del Sindrome de Wolf-Hirschhorn
INTRODUCTION: Wolf-Hirschhorn syndrome (WHS) is a contiguous gene syndrome that gives rise to multiple congenital anomalies, caused by the loss of a distal portion of the short arm of chromosome 4 (4p16.3). It is characterised by its own peculiar facial phenotype, associated to growth problems, psychomotor retardation and epilepsy. AIMS: To establish a register of patients with WHS in Spain, describe their characteristics, determine the prevalence of epilepsy, estimate the degree of psychomotor retardation and perform a review of the literature in order to compare these data with those published to date...
May 1, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28444108/racial-ethnic-differences-in-left-ventricular-structure-and-function-in-chronic-kidney-disease-the-chronic-renal-insufficiency-cohort
#10
Faraz S Ahmad, Xuan Cai, Katherine Kunkel, Ana C Ricardo, James P Lash, Dominic S Raj, Jiang He, Amanda H Anderson, Matthew J Budoff, Julie A Wright Nunes, Jason Roy, Jackson T Wright, Alan S Go, Martin G St John Sutton, John W Kusek, Tamara Isakova, Myles Wolf, Martin G Keane
BACKGROUND: Chronic kidney disease (CKD) is associated with increased risk of cardiovascular disease (CVD) and it is especially common among Blacks. Left ventricular hypertrophy (LVH) is an important subclinical marker of CVD, but there are limited data on racial variation in left ventricular structure and function among persons with CKD. METHODS: In a cross-sectional analysis of the Chronic Renal Insufficiency Cohort Study, we compared the prevalence of different types of left ventricular remodeling (concentric hypertrophy, eccentric hypertrophy, and concentric remodeling) by race/ethnicity...
April 24, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28443843/atmospheric-pressure-soft-ionization-for-gas-chromatography-with-dielectric-barrier-discharge-ionization-mass-spectrometry-gc-dbdi-ms
#11
Mario F Mirabelli, Jan-Christoph Wolf, Renato Zenobi
In this study, a gas chromatography (GC) system was interfaced to a high-resolution Orbitrap mass spectrometer by means of an active capillary plasma ionization source, based on dielectric barrier discharge ionization (DBDI). This allowed highly efficient soft ionization of gas-phase, chromatographically resolved compounds at ambient pressure. Several pesticides and illicit drugs were analyzed, and the limits of detections (LODs) were as low as 30 pg mL(-1) for the GC-DBDI-MS coupling (corresponding to 60 fg on-column sensitivity) and 30 fg mL(-1) for SPME-GC-DBDI-MS...
April 26, 2017: Analyst
https://www.readbyqxmd.com/read/28443661/engineering-of-rumb-toward-a-green-catalyst-for-carbene-insertion-reactions
#12
Matthew W Wolf, David A Vargas, Nicolai Lehnert
The small, stable heme protein myoglobin (Mb) was modified through cofactor substitution and mutagenesis to develop a new catalyst for carbene transfer reactions. The native heme was removed from wild-type Mb and several Mb His64 mutants (H64D, H64A, H64V), and the resulting apoproteins were reconstituted with ruthenium mesoporphyrin IX (RuMpIX). The reconstituted proteins (RuMb) were characterized by UV-vis and circular dichroism spectroscopy and were used as catalysts for the N-H insertion of aniline derivatives and the cyclopropanation of styrene derivatives...
April 26, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28442442/prostaglandins-and-other-lipid-mediators-polm-special-issue-of-the-6th-european-workshop-on-lipid-mediators-role-of-m%C3%A3-ller-cell-cytochrome-p450-2c44-in-murine-retinal-angiogenesis
#13
Jiong Hu, Alexandra Geyer, Sarah Dziumbla, Khader Awwad, Darryl C Zeldin, Wolf-Hagen Schunck, Rüdiger Popp, Timo Frömel, Ingrid Fleming
Polyunsaturated fatty acids (PUFA) and their cytochrome P450 (CYP450) metabolites have been linked to angiogenesis and vessel homeostasis. However, the role of individual CYP isoforms and their endogenous metabolites in those processes are not clear. Here, we focused on the role of Cyp2c44 in postnatal retinal angiogenesis and report that Cyp2c44 is highly expressed in Müller glial cells in the retina. The constitutive as well as inducible postnatal genetic deletion of Cyp2c44 resulted in an increased vessel network density without affecting vessel radial expansion during the first postnatal week...
April 22, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28442300/effects-of-mmp12-on-cell-motility-and-inflammation-during-corneal-epithelial-repair
#14
Marie Wolf, Inna Maltseva, Selene M Clay, Peipei Pan, Abhinay Gajjala, Matilda F Chan
Corneal epithelial defects are a common cause of ocular morbidity and can result in corneal scarring if they do not heal properly. Matrix metalloproteinases (MMPs) are extracellular matrix proteinases that regulate multiple aspects of corneal repair. We have previously shown that MMP12 has a protective effect on corneal fibrosis through its regulation of neutrophil and macrophage infiltration and angiogenesis in a chemical injury model involving full thickness damage to the cornea. However, the role of MMP12 in injuries limited to the corneal epithelium is relatively unknown...
April 22, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28442283/development-implementation-and-evaluation-of%C3%A2-evidence-based-cooking-videos-for-cancer%C3%A2-survivors
#15
Emily Fitz, Jim Warner, Ashlea Braun, Emily Hill, Kay Wolf, Colleen Spees
No abstract text is available yet for this article.
April 22, 2017: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/28442042/growth-arrest-specific-1-gas1-and-glial-cell-line-derived-neurotrophic-factor-receptor-%C3%AE-1-gfr%C3%AE-1-two-mouse-oocyte-glycosylphosphatidylinositol-anchored-proteins-are-involved-in-fertilisation
#16
M Agopiantz, L Xandre-Rodriguez, B Jin, G Urbistondoy, C Ialy-Radio, M Chalbi, J-P Wolf, A Ziyyat, B Lefèvre
Recently, Juno, the oocyte receptor for Izumo1, a male immunoglobulin, was discovered. Juno is an essential glycosylphosphatidylinositol (GIP)-anchored protein. This result did not exclude the participation of other GIP-anchored proteins in this process. After bibliographic and database searches we selected five GIP-anchored proteins (Cpm, Ephrin-A4, Gas1, Gfra1 and Rgmb) as potential oocyte candidates participating in fertilisation. Western blot and immunofluorescence analyses showed that only three were present on the mouse ovulated oocyte membrane and, of these, only two were clearly involved in the fertilisation process, namely growth arrest specific 1 (Gas1) and glial cell line-derived neurotrophic factor receptor α1 (Gfrα1)...
April 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28441210/artist-s-statement-inde-ma-iingan-heart-of-the-wolf
#17
Leah Yellowbird, Melissa Lewis
No abstract text is available yet for this article.
May 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28440112/patient-specific-prediction-of-functional-recovery-after-stroke
#18
Abdel Douiri, Justin Grace, Shah-Jalal Sarker, Kate Tilling, Christopher McKevitt, Charles DA Wolfe, Anthony G Rudd
Background and aims Clinical predictive models for stroke recovery could offer the opportunity of targeted early intervention and more specific information for patients and carers. In this study, we developed and validated a patient-specific prognostic model for monitoring recovery after stroke and assessed its clinical utility. Methods Four hundred and ninety-five patients from the population-based South London Stroke Register were included in a substudy between 2002 and 2004. Activities of daily living were assessed using Barthel Index) at one, two, three, four, six, eight, 12, 26, and 52 weeks after stroke...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28439819/lengthening-of-the-humerus-with-intramedullary-lengthening-nails-preliminary-report
#19
Julian Fürmetz, Søren Kold, Nikola Schuster, Florian Wolf, Peter H Thaller
Distraction osteogenesis of the humerus with fully implantable lengthening is now possible since the diameter of the available nails was reduced to 10 mm and below. We report on the first intramedullary lengthening cases of the humerus with two different lengthening devices (FITBONE and PRECICE). Two different approaches and implantation techniques were used. We retrospectively reviewed clinical and radiographic data and pointed out results, pitfalls and complications of the procedure. Four adult patients with relevant length discrepancy of the humerus were treated with fully implantable systems in two centers between 2012 and 2015...
April 24, 2017: Strategies in Trauma and Limb Reconstruction
https://www.readbyqxmd.com/read/28438723/long-term-outcomes-of-minimally-invasive-surgical-ablation-for-atrial-fibrillation-a-single-center-experience
#20
Aditya Saini, Yuhning L Hu, Vigneshwar Kasirajan, Frederick T Han, Muhammad Z Khan, Luke Wolfe, Sampath Gunda, Jayanthi N Koneru, Kenneth A Ellenbogen
BACKGROUND: Minimally invasive surgical AF ablation delivers RF energy via a thoracoscopic approach to perform pulmonary vein isolation and LA ganglionic plexi ablation. Data on long term outcomes of MISAA is lacking. OBJECTIVE: We report 5 year follow-up data from a prospective cohort of patients who underwent MISAA at a single center. METHODS: One hundred nine consecutive patients (60 paroxysmal, 49 persistent, mean age 62.7±9.3 years) underwent MISAA with left atrial appendage exclusion by a single surgeon between 2006 and 2012...
April 21, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
keyword
keyword
18052
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"