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https://www.readbyqxmd.com/read/28324888/aldo-keto-reductases-are-biomarkers-of-nrf2-activity-and-are-co-ordinately-overexpressed-in-non-small-cell-lung-cancer
#1
A Kenneth MacLeod, Lourdes Acosta-Jimenez, Philip J Coates, Michael McMahon, Frank A Carey, Tadashi Honda, John D Hayes, Colin J Henderson, C Roland Wolf
No abstract text is available yet for this article.
March 21, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28324008/vessel-network-architecture-of-adult-human-islets-promotes-distinct-cell-cell-interactions-in-situ-and-is-altered-after-transplantation
#2
Christian M Cohrs, Chunguang Chen, Stephan R Jahn, Julia Stertmann, Helena Chmelova, Jürgen Weitz, Andrea Bähr, Nikolai Klymiuk, Anja Steffen, Barbara Ludwig, Virginia Kamvissi, Eckhard Wolf, Stefan R Bornstein, Michele Solimena, Stephan Speier
Islet cell hormone release is modulated by signals from endothelial and endocrine cells within the islet. However, models of intra-islet vascularization and paracrine cell signaling are mostly based on rodent pancreas. We here assessed for the first time the architecture and endocrine cell interaction of the vascular network in unperturbed human islets in situ and their potential to re-establish their endogenous vascular network after transplantation in vivo. We prepared pancreas tissue slices of fresh tissue obtained from non-diabetic patients undergoing partial pancreatectomy...
January 27, 2017: Endocrinology
https://www.readbyqxmd.com/read/28323986/chronic-intranasal-insulin-does-not-affect-hepatic-lipids-but-lowers-circulating-bcaas-in-healthy-male-subjects
#3
Thomas Scherer, Peter Wolf, Sabina Smajis, Melania Gaggini, Martina Hackl, Amalia Gastaldelli, Peter Klimek, Elisa Einwallner, Rodrig Marculescu, Anton Luger, Clemens Fürnsinn, Siegfried Trattnig, Christoph Buettner, Martin Krššák, Michael Krebs
Context: Non-alcoholic fatty liver disease and elevated circulating branched-chain amino acids (BCAAs) are common characteristics of obesity and type 2 diabetes. In rodents, brain insulin signaling controls both hepatic triglyceride secretion and BCAA catabolism. Whether brain insulin signaling controls similar metabolic pathways in humans is unknown. Objective: Here we assessed if intranasal insulin, a method to preferentially deliver insulin to the central nervous system, is able to modulate hepatic lipid content and plasma BCAAs in humans...
January 16, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28323565/surveillance-for-highly-pathogenic-avian-influenza-in-wild-turkeys-meleagris-gallopavo-of-minnesota-during-2015-outbreaks-in-domestic-poultry
#4
Christopher S Jennelle, Michelle Carstensen, Erik C Hildebrand, Paul C Wolf, Daniel A Grear, Hon S Ip, Louis Cornicelli
An outbreak of a novel reassortant of highly pathogenic avian influenza A (H5N2) virus (HPAIV) decimated domestic turkeys ( Meleagris gallopavo ) from March through mid-June, 2015 in the state of Minnesota, USA. In response, as part of broader surveillance efforts in wild birds, we designed a pilot effort to sample and test hunter-harvested Wild Turkeys ( Meleagris gallopavo ) for HPAIV in Minnesota counties with known infected poultry facilities. We also collected opportunistic samples from dead Wild Turkeys or live Wild Turkeys showing neurologic signs (morbidity and mortality samples) reported by the public or state agency personnel...
March 21, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28319984/critical-considerations-for-the-future-of-patient-experience
#5
Jason A Wolf
No abstract text is available yet for this article.
January 2017: Journal of Healthcare Management / American College of Healthcare Executives
https://www.readbyqxmd.com/read/28319978/patient-experience-the-new-heart-of-healthcare-leadership
#6
Jason A Wolf
In a healthcare world in which consumerism is no longer a question and value has claimed its place at center stage, leaders are called to think differently about how they operate and manage their organizations. Priorities are curving in new directions with shifts in policy, direction of dollars, and evolution of practice. At the center of this transition is an opportunity for healthcare leaders to recognize that patient experience is the new heart of healthcare leadership.To address quality, safety, service, cost, and population health outcomes, leaders must rethink how they understand and engage in experience efforts overall...
April 2017: Frontiers of Health Services Management
https://www.readbyqxmd.com/read/28319562/translating-biomarkers-from-research-to-clinical-use-in-pediatric-neurocritical-care-focus-on-traumatic-brain-injury-and-cardiac-arrest
#7
Andrew J Prout, Michael S Wolf, Ericka L Fink
PURPOSE OF REVIEW: Traumatic brain injury (TBI) and cardiac arrest are important causes of morbidity and mortality in children. Improved diagnosis and outcome prognostication using validated biomarkers could allow clinicians to better tailor therapies for optimal efficacy. RECENT FINDINGS: Contemporary investigation has yielded plentiful biomarker candidates of central nervous system (CNS) injury, including macromolecules, genetic, inflammatory, oxidative, and metabolic biomarkers...
March 17, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28319093/human-haematopoietic-stem-cell-lineage-commitment-is-a-continuous-process
#8
Lars Velten, Simon F Haas, Simon Raffel, Sandra Blaszkiewicz, Saiful Islam, Bianca P Hennig, Christoph Hirche, Christoph Lutz, Eike C Buss, Daniel Nowak, Tobias Boch, Wolf-Karsten Hofmann, Anthony D Ho, Wolfgang Huber, Andreas Trumpp, Marieke A G Essers, Lars M Steinmetz
Blood formation is believed to occur through stepwise progression of haematopoietic stem cells (HSCs) following a tree-like hierarchy of oligo-, bi- and unipotent progenitors. However, this model is based on the analysis of predefined flow-sorted cell populations. Here we integrated flow cytometric, transcriptomic and functional data at single-cell resolution to quantitatively map early differentiation of human HSCs towards lineage commitment. During homeostasis, individual HSCs gradually acquire lineage biases along multiple directions without passing through discrete hierarchically organized progenitor populations...
March 20, 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28318687/protein-intake-distribution-pattern-does-not-affect-anabolic-response-lean-body-mass-muscle-strength-or-function-over-8-weeks-in-older-adults-a-randomized-controlled-trial
#9
Il-Young Kim, Scott Schutzler, Amy M Schrader, Horace J Spencer, Gohar Azhar, Robert R Wolfe, Arny A Ferrando
BACKGROUND & AIMS: In our recent acute metabolic study, we found no differences in the anabolic response to differing patterns of dietary protein intake. To confirm this in a chronic study, we investigated the effects of protein distribution pattern on functional outcomes and protein kinetics in older adults over 8 weeks. METHODS: To determine chronic effects of protein intake pattern at 1.1 g protein/kg/day in mixed meals on lean body mass (LBM), functional outcomes, whole body protein kinetics and muscle protein fractional synthesis rate (MPS) over 8-week respective dietary intervention, fourteen older subjects were randomly divided into either EVEN or UNVEN group...
March 3, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28317103/outside-the-envelope-rare-events-disrupt-the-relationship-between-climate-factors-and-species-interactions
#10
Katharine L Stuble, Emily Zefferman, Kristina Wolf, Kurt J Vaughn, Truman P Young
The order in which species arrive during community assembly can be an important driver of community composition and function. However, the strength of these priority effects can be variable, in part because of strong site and year effects. To understand how priority effects vary in importance with abiotic conditions, we initiated identical community assembly experiments in which we varied the timing of arrival of native and exotic grass species in each of four years across three grassland sites in northern California...
March 19, 2017: Ecology
https://www.readbyqxmd.com/read/28317054/theoretically-derived-mechanisms-of-hpald-photolysis-in-isoprene-oxidation
#11
Zhen Liu, Vinh Son Nguyen, Jeremy Harvey, Jean-François Müller, Jozef Peeters
In this work we identified and theoretically quantified two photolysis mechanisms of HPALDs (hydroperoxy aldehydes) that result from the isomerization of peroxy radicals in the atmospheric oxidation of isoprene at low/moderate NOx. As a first photolysis mechanism, we show that a fraction of the initially excited S1-state HPALDs isomerizes by a near-barrierless 1,5 H-shift at a rate approaching 10(12) s(-1) - competing with the ∼equally fast intersystem crossing to the T2 triplet state - forming an unstable biradical that spontaneously expels an OH (hydroxyl) radical...
March 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28316248/assessing-the-impact-of-post-traumatic-stress-symptoms-on-resting-state-function-networks-in-a-military-chronic-mild-traumatic-brain-injury-sample
#12
Dominic E Nathan, Julie F Bellgowan, Louis M French, Jonathan P Wolf, Terry Oakes, Jeannine B Mielke, Elyssa B Sham, Wei Liu, Gerard Riedy
The relationship between post traumatic stress disorder (PTSD) and chronic symptoms of mild traumatic brain injury (mTBI) is difficult to discern and poorly understood. An accurate differential diagnosis, assessment and treatment of mTBI and PTSD is challenging due to significant symptom overlap and the absence of clearly established biomarkers. The objective of this work is to examine how post traumatic stress influences task-free brain networks in chronic mTBI subjects. Control subjects (N=44) were compared with chronic mTBI subjects with low (N=58, PCLC total<30), medium (N=124, PCLC total = 31-49) and high (N=105, PCLC total ≥ 60) post traumatic stress symptoms (PTSS)...
March 19, 2017: Brain Connectivity
https://www.readbyqxmd.com/read/28315451/blue-light-induced-oxidative-stress-in-live-skin
#13
Yuya Nakashima, Shigeo Ohta, Alexander M Wolf
Skin damage from exposure to sunlight induces aging-like changes in appearance and is attributed to the ultraviolet (UV) component of light. Photosensitized production of reactive oxygen species (ROS) by UVA light is widely accepted to contribute to skin damage and carcinogenesis, but visible light is thought not to do so. Using mice expressing redox-sensitive GFP to detect ROS, blue light could produce oxidative stress in live skin. Blue light induced oxidative stress preferentially in mitochondria, but green, red, far red or infrared light did not...
March 15, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28315373/memory-for-objects-and-startle-responsivity-in-the-immediate-aftermath-of-exposure-to-the-trier-social-stress-test
#14
Nadja Herten, Dennis Pomrehn, Oliver T Wolf
Previously we observed enhanced long-term memory for objects used (central objects) by committee members in the Trier Social Stress Test (TSST) on the next day. In addition, startle responsivity was increased. However, response specificity to an odour involved in the stressful episode was lacking and recognition memory for the odour was poor. In the current experiments, immediate effects of the stressor on memory and startle responsivity were investigated. We hypothesised memory for central objects of the stressful episode and startle response specificity to an odour ambient during the TSST to be enhanced shortly after it in contrast to the control condition (friendly TSST)...
March 14, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28314474/sulforaphane-as-an-adjunctive-to-everolimus-counteracts-everolimus-resistance-in-renal-cancer-cell-lines
#15
Eva Juengel, Stephanie Euler, Sebastian Maxeiner, Jochen Rutz, Saira Justin, Frederik Roos, Wael Khoder, Karen Nelson, Wolf O Bechstein, Roman A Blaheta
BACKGROUND: The mechanistic target of rapamycin (mTOR) inhibitors, everolimus and temsirolimus, have widened therapeutic options to treat renal cell carcinoma (RCC). However, chronic treatment with these inhibitors often induces resistance, leading to therapeutic failure. PURPOSE: The natural compound, sulforaphane (SFN), was added to an everolimus based regime in vitro in the hopes of preventing resistance development. METHODS: A panel of RCC cell lines (A498, Caki-1, KTCTL-26) was treated with everolimus or SFN or with an everolimus-SFN-combination, either short- (24h) or long-term (8 weeks), and cell growth, proliferation, apoptosis, and cell cycle phases were measured...
April 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28306604/role-of-mri-in-low-risk-prostate-cancer-finding-the-wolf-in-sheep-s-clothing-or-the-sheep-in-wolf-s-clothing
#16
Ivo G Schoots, Caroline M Moore, Olivier Rouvière
PURPOSE OF REVIEW: In men on active surveillance for localized prostate cancer, MRI and MRI-targeted biopsies can be used prior to confirmatory or surveillance biopsy, to detect individuals with high-grade cancer (the wolf in sheep's clothing). However, some men will have low-risk disease despite adverse MRI findings (the sheep in wolf's clothing). We review the value addition of MRI-targeted biopsies in comparison to systematic transrectal ultrasound-guided biopsies, using pathological reclassification as an end-point...
March 16, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28306299/graviton-mass-might-reduce-tension-between-early-and-late-time-cosmological-data
#17
Antonio De Felice, Shinji Mukohyama
The standard cold dark matter model with a cosmological constant (Λ-CDM) predicts a growth of structures which tends to be higher than the values of redshift space distortion (RSD) measurements if the cosmological parameters are fixed by the cosmic microwave background data. In this Letter, we point out that this discrepancy can be resolved or understood if we assume that the graviton has a small but nonzero mass. In the context of the minimal theory of massive gravity (MTMG), due to infrared Lorentz violations measurable only at present cosmological scales, the graviton acquires a mass without being haunted by unwanted extra degrees of freedom...
March 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28303732/mitochondrial-dna-sequence-variation-in-iranian-native-dogs
#18
Zeinab Amiri Ghanatsaman, Adeniyi C Adeola, Masood Asadi Fozi, Ya-Ping Ma, Min-Sheng Peng, Guo-Dong Wang, Ali Esmailizadeh, Ya-Ping Zhang
The dog mtDNA diversity picture from wide geographical sampling but from a small number of individuals per region or breed, displayed little geographical correlation and high degree of haplotype sharing between very distant breeds. For a clear picture, we extensively surveyed Iranian native dogs (n = 305) in comparison with published European (n = 443) and Southwest Asian (n = 195) dogs. Twelve haplotypes related to haplogroups A, B and C were shared by Iranian, European, Southwest Asian and East Asian dogs...
March 17, 2017: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
https://www.readbyqxmd.com/read/28303132/mycobacterium-abscessus-subsp-abscessus-is-capable-of-degrading-pseudomonas-aeruginosa-quinolone-signals
#19
Franziska S Birmes, Timo Wolf, Thomas A Kohl, Kai Rüger, Franz Bange, Jörn Kalinowski, Susanne Fetzner
Pseudomonas aeruginosa employs 2-heptyl-3-hydroxy-4(1H)-quinolone (the Pseudomonas quinolone signal, PQS) and 2-heptyl-4(1H)-quinolone (HHQ) as quorum sensing signal molecules, which contribute to a sophisticated regulatory network controlling the production of virulence factors and antimicrobials. We demonstrate that Mycobacterium abscessus(T) and clinical M. abscessus isolates are capable of degrading these alkylquinolone signals. Genome sequences of 50 clinical M. abscessus isolates indicated the presence of aqdRABC genes, contributing to fast degradation of HHQ and PQS, in M...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28302859/inflammation-boosts-bacteriophage-transfer-between-salmonella-spp
#20
Médéric Diard, Erik Bakkeren, Jeffrey K Cornuault, Kathrin Moor, Annika Hausmann, Mikael E Sellin, Claude Loverdo, Abram Aertsen, Martin Ackermann, Marianne De Paepe, Emma Slack, Wolf-Dietrich Hardt
Bacteriophage transfer (lysogenic conversion) promotes bacterial virulence evolution. There is limited understanding of the factors that determine lysogenic conversion dynamics within infected hosts. A murine Salmonella Typhimurium (STm) diarrhea model was used to study the transfer of SopEΦ, a prophage from STm SL1344, to STm ATCC14028S. Gut inflammation and enteric disease triggered >55% lysogenic conversion of ATCC14028S within 3 days. Without inflammation, SopEΦ transfer was reduced by up to 10(5)-fold...
March 17, 2017: Science
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