Evelina Miele, Elena Anghileri, Chiara Calatozzolo, Elisabetta Lazzarini, Sara Patrizi, Andrea Ciolfi, Lucia Pedace, Monica Patanè, Luana Abballe, Rosina Paterra, Luisa Maddaloni, Sabina Barresi, Angela Mastronuzzi, Alessandra Petruzzi, Irene Tramacere, Mariangela Farinotti, Lorena Gurrieri, Elena Pirola, Mauro Scarpelli, Giuseppe Lombardi, Veronica Villani, Matteo Simonelli, Rossella Merli, Andrea Salmaggi, Marco Tartaglia, Antonio Silvani, Francesco DiMeco, Daniele Calistri, Elena Lamperti, Franco Locatelli, Stefano Indraccolo, Bianca Pollo
Five-year glioblastoma (GBM) survivors (LTS) are the minority of the isocitrate dehydrogenase (IDH)-wild-type GBM patients, and their molecular fingerprint is still largely unexplored. This multicenter retrospective study analyzed a large LTS-GBM cohort from nine Italian institutions and molecularly characterized a subgroup of patients by mutation, DNA methylation (DNAm) and copy number variation (CNV) profiling, comparing it to standard survival GBM. Mutation scan allowed the identification of pathogenic variants in most cases, showing a similar mutational spectrum in both groups, and highlighted TP53 as the most commonly mutated gene in the LTS group...
February 27, 2024: Cancer Letters