Cinzia Cocola, Edoardo Abeni, Valentina Martino, Eleonora Piscitelli, Paride Pelucchi, Ettore Mosca, Alice Chiodi, Tasnim Mohamed, Mira Palizban, Giovanni Porta, Helga Palizban, Giovanni Nano, Francesco Acquati, Antonino Bruno, Burkhard Greve, Daniela Gerovska, Valerio Magnaghi, Daniela Mazzaccaro, Giovanni Bertalot, James Kehler, Cristiana Balbino, Marcos J Arauzo-Bravo, Martin Götte, Ileana Zucchi, Rolland A Reinbold
High-grade gliomas (HGGs) and glioblastoma multiforme (GBM) are characterized by a heterogeneous and aggressive population of tissue-infiltrating cells that promote both destructive tissue remodeling and aberrant vascularization of the brain. The formation of defective and permeable blood vessels and microchannels and destructive tissue remodeling prevent efficient vascular delivery of pharmacological agents to tumor cells and are the significant reason why therapeutic chemotherapy and immunotherapy intervention are primarily ineffective...
April 3, 2024: International Journal of Molecular Sciences