keyword
https://read.qxmd.com/read/38492800/diagnostic-validity-and-reliability-of-bt-rads-in-the-management-of-recurrent-high-grade-glioma
#1
JOURNAL ARTICLE
Noha Yahia Ebaid, Rasha Nadeem Ahmed, Mostafa Mohamad Assy, Mohamed Ibrahim Amin, Ahmed Mohamad Alaa Eldin, Ahmed Mohamed Alsowey, Rabab Mohamed Abdelhay
BACKGROUND AND PURPOSE: BT-RADS is a new framework system for reporting the treatment response of brain tumors. The aim of the study was to assess the diagnostic performance and reliability of the BT-RADS in predicting the recurrence of high-grade glioma (HGG). MATERIALS AND METHODS: This prospective single-center study recruited 81 cases with previously operated and pathologically proven HGG. The patients underwent baseline and follow-up contrast-enhanced MRI (CE-MRI)...
March 14, 2024: Journal of Neuroradiology. Journal de Neuroradiologie
https://read.qxmd.com/read/38490940/pet-ct-in-comparison-with-pet-mri-as-an-imaging-modality-in-the-management-of-gliomas-a-systematic-review-and-meta-analysis
#2
REVIEW
Bareq S Al-Lami, Baqer S Al-Lami, Yasir S Al-Lami
INTRODUCTION: Gliomas are the most commonly occurring type of primary brain tumors. They account for 32% of all brain tumors and 80% of all malignant intracranial tumors. Gliomas are separated into four grades according to the World Health Organization. While low-grade gliomas generally have a favorable outlook, high-grade gliomas cause significant morbidity and mortality Given the lack of clarity about the causes of gliomas and their potential lethality, early diagnosis and identification is crucial...
March 14, 2024: Journal of Medical Imaging and Radiation Sciences
https://read.qxmd.com/read/38490442/ultrasound-guided-resection-of-high-grade-gliomas-a-single-arm-meta-analysis
#3
REVIEW
Lucca B Palavani, Márcio Yuri Ferreira, Pedro G L B Borges, Luis Bandeira, Gabriel da Silva Semione, Miguel V Almeida, Gabriel Verly, Allan Dias Polverini, Filipi Fim Andreão, Raphael Camerotte, Christian Ferreira, Wellingson Paiva, Raphael Bertani, John Boockvar
BACKGROUND: High-grade gliomas (HGG) present a challenge in neuro-oncology, often necessitating surgical resection for optimal management. Ultrasound (US) holds promise in achieving better Gross Total Resection (GTR) and improving outcomes. This meta-analysis systematically evaluates literature providing robust evidence on the use of intraoperative Ultrasonography (iUSG) in HGG resection. METHODS: Following PRISMA guidelines a comprehensive search was made across PubMed, Embase, Cochrane, and Web of Science utilized terms related to iUSG for HGG resection...
March 13, 2024: World Neurosurgery
https://read.qxmd.com/read/38487721/capacity-building-for-pediatric-neuro-oncology-in-pakistan-a-project-by-my-child-matters-program-of-foundation-s
#4
JOURNAL ARTICLE
Naureen Mushtaq, Bilal Mazhar Qureshi, Gohar Javed, Nabeel Ashfaque Sheikh, Saqib Kamran Bakhshi, Altaf Ali Laghari, Syed Ather Enam, Shayan Sirat Maheen Anwar, Kiran Hilal, Arsalan Kabir, Alia Ahmad, Amber Goraya, Anum Salman Mistry, Aqeela Rashid, Ata Ur Rehman Maaz, Muhammad Atif Munawar, Atiq Ahmed Khan, Farrah Bashir, Hina Hashmi, Kamran Saeed, Kumail Khandwala, Lal Rehman, Michael C Dewan, Muhammad Saghir Khan, Muneeb Uddin Karim, Najma Shaheen, Nida Zia, Nuzhat Yasmeen, Raheela Mahmood, Riaz Ahmed Raja Memon, Salman Kirmani, Shahzadi Resham, Shazia Kadri, Shazia Riaz, Syed Ahmer Hamid, Tariq Ghafoor, Uzma Imam, Yaseen Rauf Mushtaq, Zulfiqar Ali Rana, Eric Bouffet, Khurram Minhas
INTRODUCTION: Initiated in June 2019, this collaborative effort involved 15 public and private sector hospitals in Pakistan. The primary objective was to enhance the capacity for pediatric neuro-oncology (PNO) care, supported by a My Child Matters/Foundation S grant. METHODS: We aimed to establish and operate Multidisciplinary Tumor Boards (MTBs) on a national scale, covering 76% of the population (185.7 million people). In response to the COVID-19 pandemic, MTBs transitioned to videoconferencing...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38487309/the-impact-of-meis1-tale-homeodomain-transcription-factor-knockdown-on-glioma-stem-cell-growth
#5
JOURNAL ARTICLE
Hyun-Jin Kim, Don Carlo Batara, Young-Jun Jeon, Seongsoo Lee, Samuel Beck, Sung-Hak Kim
Myeloid ecotropic virus insertion site 1 ( MEIS1 ) is a HOX co-factor necessary for organ development and normal hematopoiesis. Recently, MEIS1 has been linked to the development and progression of various cancers. However, its role in gliomagenesis particularly on glioma stem cells (GSCs) remains unclear. Here, we demonstrate that MEIS1 is highly upregulated in GSCs compared to normal, and glioma cells and to its differentiated counterparts. Inhibition of MEIS1 expression by shRNA significantly reduced GSC growth in both in vitro and in vivo experiments...
2024: Animal Cells and Systems
https://read.qxmd.com/read/38485198/high-grade-astrocytoma-with-piloid-features-a-dual-institutional-review-of-imaging-findings-of-a-novel-entity
#6
JOURNAL ARTICLE
Neetu Soni, Amit Agarwal, Pranav Ajmera, Parv Mehta, Vivek Gupta, Mukta Vibhute, Maria Gubbiotti, Ian T Mark, Steven A Messina, Suyash Mohan, Girish Bathla
High-grade astrocytoma with piloid features (HGAP) is a recently identified brain tumor characterized by a distinct DNA methylation profile. Predominantly located in the posterior fossa of adults, HGAP is notably prevalent in individuals with neurofibromatosis type 1. We present an image-centric review of HGAP and explore the association between HGAP and neurofibromatosis type 1. Data were collected from 8 HGAP patients treated at two tertiary care institutions between January 2020 and October 2023. Demographic details, clinical records, management, and tumor molecular profiles were analyzed...
March 14, 2024: AJNR. American Journal of Neuroradiology
https://read.qxmd.com/read/38483435/longitudinal-impact-of-intracerebral-low-grade-glioma-disease-on-health-related-quality-of-life
#7
JOURNAL ARTICLE
Laurèl Rauschenbach, Pauline Bartsch, Alejandro N Santos, Anna Michel, Hanah H Gull, Pikria Ketelauri, Marvin Darkwah Oppong, Börge Schmidt, Celia Dobersalske, Tobias Blau, Yahya Ahmadipour, Ramazan Jabbarli, Karsten H Wrede, Ulrich Sure, Philipp Dammann
BACKGROUND: The aim of this study was to assess health-related quality of life (HRQOL) before and after treatment for intracerebral low-grade glioma. METHODS: Patients with low-grade glioma who underwent surgical tumor removal between 2012 and 2018 were eligible for this study. All individuals and their closest relatives received thorough preoperative (<seven days before surgery) and posttreatment (12 months after surgery) neuropsychological testing investigating quality of life...
March 14, 2024: Journal of Neurosurgical Sciences
https://read.qxmd.com/read/38482443/comprehensive-analysis-of-the-effects-of-the-cuprotosis-associated-gene-slc31a1-on-patient-prognosis-and-tumor-microenvironment-in-human-cancer
#8
JOURNAL ARTICLE
Guiqian Zhang, Ning Wang, Shixun Ma, Pengxian Tao, Hui Cai
BACKGROUND: Solute carrier family 31 (copper transporter), member 1 ( SLC31A1 ) is a key factor in maintaining intracellular copper concentration and an important factor affecting cancer energy metabolism. Therefore, exploring the potential biological function and value of SLC31A1 could provide a new direction for the targeted therapy of tumors. METHODS: This study assessed gene expression levels, survival, clinicopathology, gene mutations, methylation levels, the tumor mutational burden (TMB), microsatellite instability (MSI), and the immune cell infiltration of SLC31A1 in pan-cancer using the Tumor Immune Estimation Resource 2...
February 29, 2024: Translational Cancer Research
https://read.qxmd.com/read/38477830/n-cadherin-dynamically-regulates-pediatric-glioma-cell-migration-in-complex-environments
#9
JOURNAL ARTICLE
Dayoung Kim, James M Olson, Jonathan A Cooper
Pediatric high-grade gliomas are highly invasive and essentially incurable. Glioma cells migrate between neurons and glia, along axon tracts, and through extracellular matrix surrounding blood vessels and underlying the pia. Mechanisms that allow adaptation to such complex environments are poorly understood. N-cadherin is highly expressed in pediatric gliomas and associated with shorter survival. We found that intercellular homotypic N-cadherin interactions differentially regulate glioma migration according to the microenvironment, stimulating migration on cultured neurons or astrocytes but inhibiting invasion into reconstituted or astrocyte-deposited extracellular matrix...
June 3, 2024: Journal of Cell Biology
https://read.qxmd.com/read/38477525/advanced-imaging-in-the-diagnosis-and-response-assessment-of-high-grade-glioma-ajr-expert-panel-narrative-review
#10
REVIEW
Leland S Hu, Marion Smits, Timothy J Kaufmann, Linda Knutsson, Otto Rapalino, Norbert Galldiks, Pia C Sundgrene, Soonmee Cha
This AJR Expert Panel Narrative explores the current status of advanced MRI and PET techniques for the post-therapeutic response assessment of high-grade adult-type gliomas, focusing on ongoing clinical controversies in current practice. Discussed techniques that complement conventional MRI and aid the differentiation of recurrent tumor from post-treatment effects include DWI and diffusion tensor imaging; perfusion MRI techniques including dynamic susceptibility contrast (DSC), dynamic contrast-enhanced MRI, and arterial spin labeling; MR spectroscopy including assessment of 2-hydroxyglutarate (2HG) concentration; glucose- and amino acid (AA)-based PET; and amide proton transfer imaging...
March 13, 2024: AJR. American Journal of Roentgenology
https://read.qxmd.com/read/38476871/homeostatic-status-of-thyroid-hormones-and-brain-water-movement-as-determinant-factors-in-biology-of-cerebral-gliomas-a-pilot-study-using-a-bioinformatics-approach
#11
JOURNAL ARTICLE
Carmelita Bastos Mendes, Lanni Sarmento da Rocha, Carlos Alberto de Carvalho Fraga, Adriana Ximenes-da-Silva
INTRODUCTION: The expression and localization of the water channel transporters, aquaporins (AQPs), in the brain are substantially modified in gliomas during tumorigenesis, cell migration, edema formation, and resolution. We hypothesized that the molecular changes associated with AQP1 and AQP4 in the brain may potentially be anticancer therapeutic targets. To test this hypothesis, a bioinformatics analysis of publicly available data from international consortia was performed. METHODS: We used RNA-seq as an experimental strategy and identified the number of differential AQP1 and AQP4 transcript expressions in glioma tissue compared to normal brain tissue...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38476427/stereotactic-biopsy-for-brain-lesions-doing-more-with-less
#12
JOURNAL ARTICLE
Mayank Singh, T P Waseem Ahamed, Ved Prakash Maurya, Pragya Gupta, Kamlesh Singh Bhaisora, Arun Kumar Srivastava, Pawan Kumar Verma, Kuntal Kanti Das, Ashutosh Kumar, Priyadarshi Dikshit, Anant Mehrotra, Awadhesh Kumar Jaiswal, Sanjay Behari, Raj Kumar
OBJECTIVES: Stereotactic biopsy (STB) is a potential diagnostic tool considering its minimal invasiveness, high diagnostic yield, and minimal associated complications. Over the years, various frame-based instrument systems and frameless stereotactic biopsy systems have emerged to be employed in clinical use. With this study, we intend to get more by doing less in the form of STB for the patients of doubtful intracranial lesions treated over the past 5 years. We also want to highlight the technique of performing the procedure under scalp block, which can be used as a versatile tool in many clinical scenarios...
2024: Journal of Neurosciences in Rural Practice
https://read.qxmd.com/read/38474320/identification-of-key-molecular-pathways-and-associated-genes-as-targets-to-overcome-radiotherapy-resistance-using-a-combination-of-radiotherapy-and-immunotherapy-in-glioma-patients
#13
JOURNAL ARTICLE
Tianqi Zhang, Qiao Zhang, Xinwei He, Yuting Lu, Andrew Shao, Xiaoqiang Sun, Yongzhao Shao
Recent mechanistic studies have indicated that combinations of radiotherapy (RT) plus immunotherapy (via CSF-1R inhibition) can serve as a strategy to overcome RT resistance and improve the survival of glioma mice. Given the high mortality rate for glioma, including low-grade glioma (LGG) patients, it is of critical importance to investigate the mechanism of the combination of RT and immunotherapy and further translate the mechanism from mouse studies to improve survival of RT-treated human glioma patients...
March 6, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38473812/intrinsic-and-microenvironmental-drivers-of-glioblastoma-invasion
#14
REVIEW
Emerson De Fazio, Matilde Pittarello, Alessandro Gans, Bikona Ghosh, Hasan Slika, Paolo Alimonti, Betty Tyler
Gliomas are diffusely infiltrating brain tumors whose prognosis is strongly influenced by their extent of invasion into the surrounding brain tissue. While lower-grade gliomas present more circumscribed borders, high-grade gliomas are aggressive tumors with widespread brain infiltration and dissemination. Glioblastoma (GBM) is known for its high invasiveness and association with poor prognosis. Its low survival rate is due to the certainty of its recurrence, caused by microscopic brain infiltration which makes surgical eradication unattainable...
February 22, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38473403/haploinsufficiency-of-adenomatous-polyposis-coli-coupled-with-kirsten-rat-sarcoma-viral-oncogene-homologue-activation-and-p53-loss-provokes-high-grade-glioblastoma-formation-in-mice
#15
JOURNAL ARTICLE
Kuan-Te Fang, Chuan-Shiang Su, Jhoanna Jane Layos, Nga Yin Sadonna Lau, Kuang-Hung Cheng
Glioblastoma multiforme (GBM) is the most common and deadly type of brain tumor originating from glial cells. Despite decades of clinical trials and research, there has been limited success in improving survival rates. However, molecular pathology studies have provided a detailed understanding of the genetic alterations associated with the formation and progression of glioblastoma-such as Kirsten rat sarcoma viral oncogene homolog (KRAS) signaling activation (5%), P53 mutations (25%), and adenomatous polyposis coli (APC) alterations (2%)-laying the groundwork for further investigation into the biological and biochemical basis of this malignancy...
March 4, 2024: Cancers
https://read.qxmd.com/read/38473288/establishment-of-different-intraoperative-monitoring-and-mapping-techniques-and-their-impact-on-survival-extent-of-resection-and-clinical-outcome-in-patients-with-high-grade-gliomas-a-series-of-631-patients-in-14-years
#16
JOURNAL ARTICLE
Franziska Staub-Bartelt, Marian Preetham Suresh Babu, Andrea Szelényi, Marion Rapp, Michael Sabel
BACKGROUND: The resection of brain tumors can be critical concerning localization, but is a key point in treating gliomas. Intraoperative neuromonitoring (IONM), awake craniotomy, and mapping procedures have been incorporated over the years. Using these intraoperative techniques, the resection of eloquent-area tumors without increasing postoperative morbidity became possible. This study aims to analyze short-term and particularly long-term outcomes in patients diagnosed with high-grade glioma, who underwent surgical resection under various technical intraoperative settings over 14 years...
February 25, 2024: Cancers
https://read.qxmd.com/read/38468047/computational-fractal-based-analysis-of-mr-susceptibility-weighted-imaging-swi-in-neuro-oncology-and-neurotraumatology
#17
JOURNAL ARTICLE
Antonio Di Ieva
Susceptibility-weighted imaging (SWI) is a magnetic resonance imaging (MRI) technique able to depict the magnetic susceptibility produced by different substances, such as deoxyhemoglobin, calcium, and iron. The main application of SWI in clinical neuroimaging is detecting microbleedings and venous vasculature. Quantitative analyses of SWI have been developed over the last few years, aimed to offer new parameters, which could be used as neuroimaging biomarkers. Each technique has shown pros and cons, but no gold standard exists yet...
2024: Advances in Neurobiology
https://read.qxmd.com/read/38467767/psmb2-plays-an-oncogenic-role-in-glioma-and-correlates-to-the-immune-microenvironment
#18
JOURNAL ARTICLE
Wei He, Zhe Zhang, ZiLong Tan, XinXian Liu, ZeKun Wang, Bo Xiong, XiaoLi Shen, XinGen Zhu
There has been an upward trend in the incidence of glioma, with high recurrence and high mortality. The beta subunits of the 20S proteasome are encoded by the proteasome beta (PSMB) genes and may affect the proteasome's function in glioma, assembly and inhibitor binding. This study attempted to reveal the function of the proliferation and invasion of glioma cells, which is affected by proteasome 20S subunit beta 2 (PSMB2). We subjected the data downloaded from the TCGA database to ROC, survival, and enrichment analyses...
March 11, 2024: Scientific Reports
https://read.qxmd.com/read/38463813/potential-role-of-pofut1-as-a-prognostic-predictor-in-low-grade-gliomas-immune-microenvironment-insights-from-a-pan-cancer-analysis
#19
JOURNAL ARTICLE
Fan Yu, Shuang Lou, Haihong He, Yiwen Zhou
The POFUT1 gene, known to be up-regulated in various tumor tissues and associated with tumor biology, has yet to be explored for its potential role in immune response regulation and tumor immune microenvironment. The normalized pan-cancer dataset (TCGA Pan-Cancer) was downloaded from the UCSC database, followed by analysis of POFUT1 expression in various tumors and functional enrichment analysis. The correlation between POFUT1 expression levels and patient prognosis was assessed. GSEA of POFUT1 based on low-grade glioma (LGG) samples and immune infiltration analyses of LGG and glioblastoma (GBM) were conducted...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38455766/circulating-serum-mir-362-3p-and-mir-6721-5p-as-potential-biomarkers-for-classification-patients-with-adult-type-diffuse-glioma
#20
JOURNAL ARTICLE
Magdalena Niemira, Agnieszka Bielska, Karolina Chwialkowska, Justyna Raczkowska, Anna Skwarska, Anna Erol, Anna Zeller, Gabriela Sokolowska, Damian Toczydlowski, Iwona Sidorkiewicz, Zenon Mariak, Joanna Reszec, Tomasz Lyson, Marcin Moniuszko, Adam Kretowski
According to the fifth edition of the WHO Classification of Tumours of the Central Nervous System (CNS) published in 2021, grade 4 gliomas classification includes IDH-mutant astrocytomas and wild-type IDH glioblastomas. Unfortunately, despite precision oncology development, the prognosis for patients with grade 4 glioma remains poor, indicating an urgent need for better diagnostic and therapeutic strategies. Circulating miRNAs besides being important regulators of cancer development could serve as promising diagnostic biomarkers for patients with grade 4 glioma...
2024: Frontiers in Molecular Biosciences
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