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https://www.readbyqxmd.com/read/28548546/the-risk-of-herpes-zoster-in-patients-with-ankylosing-spondylitis-analysis-of-the-korean-national-health-insurance-service-sample-cohort-database
#1
Doo-Ho Lim, Ye-Jee Kim, Seon Ok Kim, Seokchan Hong, Chang-Keun Lee, Bin Yoo, Yong-Gil Kim
OBJECTIVES: The aims of our study were to determine whether the use of conventional disease-modifying antirheumatic drugs (cDMARDs) or tumor necrosis factor α (TNFα) inhibitors increase the risk of herpes zoster (HZ) in patients with ankylosing spondylitis (AS). METHODS: We searched the South Korean National Health Insurance Service - National Sample Cohort Database for relevant patient records between 2002 and 2013. We evaluated the incidence of HZ by categorizing patients into in three treatment groups: disease-modifying antirheumatic drug (DMARD) nonusers, cDMARD users and TNFα inhibitor users...
May 26, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28547002/oncolytic-herpes-simplex-virus-inhibits-pediatric-brain-tumor-migration-and-invasion
#2
Julia V Cockle, Anke Brüning-Richardson, Karen J Scott, Jill Thompson, Timothy Kottke, Ewan Morrison, Azam Ismail, Angel M Carcaboso, Ailsa Rose, Peter Selby, Joe Conner, Susan Picton, Susan Short, Richard Vile, Alan Melcher, Elizabeth Ilett
Pediatric high-grade glioma (pHGG) and diffuse intrinsic pontine glioma (DIPG) are invasive tumors with poor survival. Oncolytic virotherapy, initially devised as a direct cytotoxic treatment, is now also known to act via immune-mediated mechanisms. Here we investigate a previously unreported mechanism of action: the inhibition of migration and invasion in pediatric brain tumors. We evaluated the effect of oncolytic herpes simplex virus 1716 (HSV1716) on the migration and invasion of pHGG and DIPG both in vitro using 2D (scratch assay, live cell imaging) and 3D (spheroid invasion in collagen) assays and in vivo using an orthotopic xenograft model of DIPG invasion...
June 16, 2017: Molecular Therapy Oncolytics
https://www.readbyqxmd.com/read/28546031/bovine-herpes-virus-type-4-alters-tnf-%C3%AE-and-il-8-profiles-and-impairs-the-survival-of-bovine-endometrial-epithelial-cells
#3
Metasu Chanrot, Gunilla Blomqvist, Yongzhi Guo, Karin Ullman, Mikael Juremalm, Renee Bage, Gaetano Donofrio, Jean-Francois Valarcher, Patrice Humblot
Bovine herpes virus type 4 (BoHV-4) can be transmitted by contaminated semen to cows at the time of breeding and may cause uterine disease. The aim of this study was to characterize the susceptibility of bovine endometrial epithelial cells (bEEC) to BoHV-4 by using an in vitro model. When bEEC were challenged with different multiplicity of infection (MOI; from 0.001 to 10) of BoHV-4 for 6days, a significant decrease in cell survival with increasing MOI was observed. The bEEC were subsequently challenged with BoHV-4 MOI 0...
May 22, 2017: Reproductive Biology
https://www.readbyqxmd.com/read/28545682/percutaneous-microwave-ablation-of-renal-cancers-under-ct-guidance-safety-and-efficacy-with-a-2-year-follow-up
#4
P Chan, S Vélasco, G Vesselle, S Boucebci, G Herpe, B Debaene, P Ingrand, J Irani, J-P Tasu
AIM: To evaluate the safety and efficiency of percutaneous microwave ablation (MWA) of renal cell carcinomas (RCC) carried out under computed tomography (CT) guidance. MATERIALS AND METHODS: A retrospective study was performed on RCC that was either histologically proven or diagnosed at imaging (Bosniak IV cyst) and treated by MWA under general anaesthesia with CT guidance. Indications for percutaneous ablation were based on the American Urological Association recommendations...
May 22, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28545358/molecular-imaging-of-tumor-angiogenesis-and-therapeutic-effects-with-dual-bioluminescence
#5
Ran Wang, Kaiyue Zhang, Hongyan Tao, Wei Du, Di Wang, Ziwei Huang, Manqian Zhou, Yang Xu, Yuebing Wang, Na Liu, Hui Wang, Zongjin Li
BACKGROUND: Angiogenesis is critical for the growth of tumor by supplying nutrients and oxygen that exacerbates the metastasis and progression of cancer. Noninvasive imaging of angiogenesis during the tumor therapeutic processes may provide novel opportunities for image-guided tumor management. OBJECTIVE: Here, we want to develop a mouse animal model for assessing cancer progression and angiogenesis in the same individuals by molecular imaging. METHODS: Breast cancer model was developed with mouse breast cancer cell line 4T1 carrying a reporter system encoding a triple fusion (TF) reporter gene consisting of renilla luciferase (Rluc), red fluorescent protein (RFP) and herpes simplex virus truncated thymidine kinase (HSV-ttk) in transgenic mice, which expressed firefly luciferase (Fluc) under the promoter of vascular endothelial growth factor receptor 2 (Vegfr2-luc)...
May 23, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28545047/the-natural-history-of-varicella-zoster-virus-infection-in-norway-further-insights-on-exogenous-boosting-and-progressive-immunity-to-herpes-zoster
#6
Luigi Marangi, Grazina Mirinaviciute, Elmira Flem, Gianpaolo Scalia Tomba, Giorgio Guzzetta, Birgitte Freiesleben de Blasio, Piero Manfredi
We use age-structured models for VZV transmission and reactivation to reconstruct the natural history of VZV in Norway based on available pre-vaccination serological data, contact matrices, and herpes zoster incidence data. Depending on the hypotheses on contact and transmission patterns, the basic reproduction number of varicella in Norway ranges between 3.7 and 5.0, implying a vaccine coverage between 73 and 80% to effectively interrupt transmission with a 100% vaccine efficacy against infection. The varicella force of infection peaks during early childhood (3-5 yrs) and shows a prolonged phase of higher risk during the childbearing period, though quantitative variations can occur depending on contact patterns...
2017: PloS One
https://www.readbyqxmd.com/read/28543846/congenital-herpes-simplex-virus-type-1-infection-mimicking-congenital-erosive-and-vesicular-dermatosis-possible-pathogenic-insights
#7
Andrew W Swarbrick, Christopher C Blyth, Anne R Halbert
Congenital erosive and vesicular dermatosis (CEVD) is a rare entity of unknown etiology. We report a case of congenital herpes simplex virus (HSV) type 1 infection that healed with reticulated and supple scarring, similar to that seen in CEVD. Twenty percent of previously reported cases of CEVD had recurrent HSV infection throughout the first year of life. We postulate that at least some previous cases of CEVD may have been due to undiagnosed congenital HSV infection.
May 25, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28542478/structural-basis-of-nectin-1-recognition-by-pseudorabies-virus-glycoprotein-d
#8
An Li, Guangwen Lu, Jianxun Qi, Lili Wu, Kegong Tian, Tingrong Luo, Yi Shi, Jinghua Yan, George F Gao
An early and yet indispensable step in the alphaherpesvirus infection is the engagement of host receptors by the viral envelope glycoprotein D (gD). Of the thus-far identified gD receptors, nectin-1 is likely the most effective in terms of its wide usage by multiple alphaherpesviruses for cell entry. The molecular basis of nectin-1 recognition by the gD protein is therefore an interesting scientific question in the alphaherpesvirus field. Previous studies focused on the herpes simplex virus (HSV) of the Simplexvirus genus, for which both the free gD structure and the gD/nectin-1 complex structure were reported at high resolutions...
May 19, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28540752/herpes-zoster-typical-and-atypical-presentations
#9
Roy Rafael Dayan, Roni Peleg
Varicella- zoster virus infection is an intriguing medical entity that involves many medical specialties including infectious diseases, immunology, dermatology, and neurology. It can affect patients from early childhood to old age. Its treatment requires expertise in pain management and psychological support. While varicella is caused by acute viremia, herpes zoster occurs after the dormant viral infection, involving the cranial nerve or sensory root ganglia, is re-activated and spreads orthodromically from the ganglion, via the sensory nerve root, to the innervated target tissue (skin, cornea, auditory canal, etc...
May 25, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/28540320/delayed-diagnosis-of-tuberculous-meningitis-misdiagnosed-as-herpes-simplex-virus-1-encephalitis-with-the-filmarray-syndromic-polymerase-chain-reaction-panel
#10
Carlos A Gomez, Benjamin A Pinsky, Anne Liu, Niaz Banaei
The FilmArray meningitis/encephalitis (ME) panel is a novel syndromic, nucleic acid amplification test for diagnosis of acute meningitis and encephalitis. Emerging data on its performance are concerning for false-positive results. We present a case of tuberculous meningitis misdiagnosed as herpes simplex virus-1 encephalitis with the FilmArray ME panel. Strategies to mitigate erroneous results are discussed.
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28540095/rituximab-monotherapy-in-the-management-of-a-rare-case-of-an-hiv-associated-lymphoproliferative-disorder
#11
Jason Hew, Fauzia Rana, Louise Zhou
Background. Castleman's disease (CD), also known as angiofollicular node hyperplasia, is a rare heterogenous lymphoproliferative disorder. This disease exists as two distinct entities: a localized or unicentric CD (UCD) which has a more benign clinical course and multicentric CD (MCD) which is a systemic disease and carries a worse prognosis. MCD is often associated with human immunodeficiency virus (HIV) infection and these patients are usually coinfected with human herpes virus-8 (HHV-8). Rituximab is an anti-CD20 monoclonal antibody that has become integral to the management of this disease...
2017: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/28539913/herpes-simplex-virus-type-2-myelitis-case-report-and-review-of-the-literature
#12
Raffaele Nardone, Viviana Versace, Francesco Brigo, Frediano Tezzon, Giulio Zuccoli, Slaven Pikija, Larissa Hauer, Johann Sellner
Non-traumatic myelopathies can result from a wide spectrum of conditions including inflammatory, ischemic, and metabolic disorders. Here, we describe the case of a 60-year old immunocompetent woman who developed acute back pain followed by rapidly ascending flaccid tetraparesis, a C6 sensory level, and sphincter dysfunction within 8 h. Acyclovir and steroids were started on day 2 and herpes simplex virus type 2 (HSV-2) was confirmed by polymerase chain reaction in cerebrospinal fluid. Magnetic resonance imaging revealed a bilateral anterior horn tractopathy expanding from C2 to T2 and cervicothoracic cord swelling...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28539620/a-core-extended-naphtalene-diimide-g-quadruplex-ligand-potently-inhibits-herpes-simplex-virus-1-replication
#13
Sara Callegaro, Rosalba Perrone, Matteo Scalabrin, Filippo Doria, Giorgio Palù, Sara N Richter
G-quadruplexes (G4s) are nucleic acids secondary structures, epigenetic regulators in cells and viruses. In herpes simplex virus 1 (HSV-1)-infected cells, G4s are massively present during viral replication. We here aimed at investigating the possibility to target the HSV-1 G4s by a core extended naphtalene diimide (c-exNDI) G4 ligand. Biophysical and biomolecular analysis proved that c-exNDI stabilized the HSV-1 G4s in a concentration dependent manner. In MS competition assays, c-exNDI preferentially recognized HSV-1 G4s over cellular telomeric G4s, the most represented G4s within cells; other less abundant cellular G4s were also recognized...
May 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28539588/cooperation-of-oncolytic-herpes-virotherapy-and-pd-1-blockade-in-murine-rhabdomyosarcoma-models
#14
Chun-Yu Chen, Pin-Yi Wang, Brian Hutzen, Les Sprague, Hayley M Swain, Julia K Love, Joseph R Stanek, Louis Boon, Joe Conner, Timothy P Cripe
Oncolytic virotherapy is an effective immunotherapeutic approach for cancer treatment via a multistep process including direct tumor cell lysis, induction of cytotoxic or apoptosis-sensitizing cytokines and promotion of antitumor T cell responses. Solid tumors limit the effectiveness of immunotherapeutics in diverse ways such as secretion of immunosuppressive cytokines and expression of immune inhibitory ligands to inhibit antitumor T cell function. Blocking programmed cell death protein (PD)-1 signaling, which mediates T cell suppression via engagement of its inhibitory ligands, PD-L1 or PD-L2, is of particular interest due to recent successes in many types of cancer...
May 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28539429/bolstering-the-number-and-function-of-hsv-1-specific-cd8-effector-memory-t-cells-and-tissue-resident-memory-t-cells-in-latently-infected-trigeminal-ganglia-reduces-recurrent-ocular-herpes-infection-and-disease
#15
Arif A Khan, Ruchi Srivastava, Aziz A Chentoufi, Elizabeth Kritzer, Sravya Chilukuri, Sumit Garg, David C Yu, Hawa Vahed, Lei Huang, Sabrina A Syed, Julie N Furness, Tien T Tran, Nesburn B Anthony, Christine E McLaren, John Sidney, Alessandro Sette, Randolph J Noelle, Lbachir BenMohamed
HSV type 1 (HSV-1) is a prevalent human pathogen that infects >3.72 billion individuals worldwide and can cause potentially blinding recurrent corneal herpetic disease. HSV-1 establishes latency within sensory neurons of trigeminal ganglia (TG), and TG-resident CD8(+) T cells play a critical role in preventing its reactivation. The repertoire, phenotype, and function of protective CD8(+) T cells are unknown. Bolstering the apparent feeble numbers of CD8(+) T cells in TG remains a challenge for immunotherapeutic strategies...
May 24, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28538997/immunotherapy-of-recurrent-herpes-labialis-with-squaric-acid
#16
Maria Alora Palli, Hugh McTavish, Alexa Kimball, Thomas D Horn
No abstract text is available yet for this article.
May 24, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28538207/association-of-serum-ninjurin2-levels-with-neurologic-damage-and-postherpetic-neuralgia-occurrence-an-observational-cohort-study-in-chinese-herpeszoster-patients
#17
Guozhuan Zhang, Yingjiao Sun, Lei Wang, Hui Tian, Lishuang Liang
OBJECTIVES: Postherpetic neuralgia(PHN) is the most common complication of herpeszoster (HZ) infection. The study aimed to explore whether serum Ninjurin2 (for nerve injury-induced protein 2, NINJ2), a novel neurologic damage related protein, is associated with nerve injury and the occurrence of PHN. RESULTS: Seventy-four of the eighty patients completed the study. On the 7th day of AHN, the patients had significantly higher values of NINJ2, cold-sense dispersion (ΔCS), warm-sense dispersion (ΔWS), cold-pain dispersion (ΔCP), heat-pain dispersion (ΔHP) and NRS score compared to controls...
May 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28538165/the-complexity-in-herpesvirus-entry
#18
REVIEW
Karthik Sathiyamoorthy, Jia Chen, Richard Longnecker, Theodore S Jardetzky
Enveloped viruses have evolved diverse transmembrane proteins and protein complexes to enable host cell entry by regulating and activating membrane fusion in a target cell-specific manner. In general terms, the entry process requires a receptor binding step, an activation step and a membrane fusion step, which can be encoded within a single viral protein or distributed among multiple viral proteins. HIV and influenza virus, for example, encode all of these functions in a single trimeric glycoprotein, HIV env or influenza virus hemagglutinin (HA)...
May 21, 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/28536353/the-continued-promise-and-many-disappointments-of-oncolytic-virotherapy-in-gastrointestinal-malignancies
#19
REVIEW
Daniel H Ahn, Tanios Bekaii-Saab
Oncolytic virotherapy represents a novel therapeutic strategy in the treatment of gastrointestinal malignancies. Oncolytic viruses, including genetically engineered and naturally occurring viruses, can selectively replicate in and induce tumor cell apoptosis without harming normal tissues, thus offering a promising tool in the armamentarium for cancer therapy. While this approach has garnered much interest over the past several decades, there has not been significant headway across various tumor types. The recent approval of talimogene laherparepvec, a second-generation oncolytic herpes simplex virus type-1, for the treatment of metastatic melanoma, confirms the therapeutic potential of oncolytic viral therapy...
March 4, 2017: Biomedicines
https://www.readbyqxmd.com/read/28536268/endoplasmic-reticulum-stress-induced-degradation-of-dnajb12-stimulates-bok-accumulation-and-primes-cancer-cells-for-apoptosis
#20
Pattarawut Sopha, Hong Yu Ren, Diane E Grove, Douglas M Cyr
DNAJB12 (JB12) is an endoplasmic reticulum (ER)-associated Hsp40 family protein that recruits Hsp70 to the ER surface to coordinate the function of ER-associated and cytosolic chaperone systems in protein quality control. Hsp70 is stress inducible, but paradoxically, we report here that JB12 was degraded by the proteasome during severe ER stress. Destabilized JB12 was degraded by ER-associated degradation (ERAD) complexes that contained HERP, Sel1L, and gp78. JB12 was the only ER-associated chaperone that was destabilized by reductive stress...
May 23, 2017: Journal of Biological Chemistry
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