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https://www.readbyqxmd.com/read/28944968/pediatric-vaccine-strain-herpes-zoster-a-case-series
#1
Sean Dreyer, Peera Hemarajata, Marcia Hogeling, Gregory P Henderson
BACKGROUND/OBJECTIVES: Herpes zoster (HZ) is caused by reactivation of the varicella zoster virus (VZV), and typically causes a painful, vesicular, dermatomal rash in adults over the age of fifty. However, HZ has been known to present in immunocompetent pediatric patients, which account for under 1% of total cases. Pediatric cases are typically caused by natural infection with VZV, but among vaccinated children up to half of cases can be due to vaccine-strain VZV. We present two such cases of vaccine-strain HZ in pediatric patients...
September 25, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28943388/corneal-higher-order-aberrations-and-visual-improvement-following-corneal-transplantation-in-treating-herpes-simplex-keratitis
#2
Eisuke Shimizu, Takefumi Yamaguchi, Daisuke Tomida, Yukari Yagi-Yaguchi, Yoshiyuki Satake, Kazuo Tsubota, Jun Shimazaki
PURPOSE: To examine corneal higher-order aberrations (HOAs) and visual improvement following corneal transplantation in treating corneal scar caused by herpes simplex keratitis (HSK). DESIGN: Retrospective consecutive case series. METHODS: This study included a total of 52 eyes: 18 normal subjects, and 34 eyes of consecutive patients with corneal scar due to HSK who underwent penetrating keratoplasty (PKP, 17 eyes) or deep anterior lamellar keratoplasty (DALK, 17 eyes)...
September 21, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28943043/discovery-of-potent-antiviral-hsv-1-quinazolinones-and-initial-structure-activity-relationship-studies
#3
Carla E Brown, Tiffany Kong, James McNulty, Leonardo D'Aiuto, Kelly Williamson, Lora McClain, Paolo Piazza, Vishwajit L Nimgaonkar
The discovery of antiviral activity of 2,3-disubstituted quinazolinones, prepared by a one-pot, three-component condensation of isatoic anhydride with amines and aldehydes, against Herpes Simplex Virus (HSV)-1 is reported. Sequential iterative synthesis/antiviral assessment allowed structure-activity relationship (SAR) generation revealing synergistic structural features required for potent anti-HSV-1 activity. The most potent derivatives show greater efficacy than acyclovir against acute HSV-1 infections in neurons and minimal toxicity to the host...
September 14, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28942398/disseminated-herpes-zoster-causing-acute-respiratory-distress-syndrome-in-an-immunocompetent-patient
#4
David M Rudinsky, Kim Jordan
Disseminated cutaneous varicella herpes zoster with visceral involvement is rare and seen almost exclusively in immunocompromised patients. We describe an unusual case of fulminant herpes zoster (HZ) in a healthy, immunocompetent 37-year-old woman. She initially presented to an urgent care centre with a classic HZ rash localised to her neck, and upper respiratory symptoms and was treated with prednisone and cephalexin. Within 1 week, the rash became diffuse and her clinical status rapidly deteriorated with development of severe acute respiratory distress syndrome...
September 23, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28942324/morphological-changes-in-different-populations-of-bladder-afferent-neurons-detected-by-herpes-simplex-virus-hsv-vectors-with-cell-type-specific-promoters-in-mice-with-spinal-cord-injury
#5
Nobutaka Shimizu, Mark F Doyal, William F Goins, Katsumi Kadekawa, Naoki Wada, Anthony J Kanai, William C de Groat, Akihide Hirayama, Hirotsugu Uemura, Joseph C Glorioso, Naoki Yoshimura
Functional and morphological changes in C-fiber bladder afferent pathways are reportedly involved in neurogenic detrusor overactivity (NDO) after spinal cord injury (SCI). This study examined the morphological changes in different populations of bladder afferent neurons after SCI using replication-defective herpes simplex virus (HSV) vectors encoding the mCherry reporter driven by neuronal cell type-specific promoters. Spinal intact (SI) and SCI mice were injected into the bladder wall with HSV mCherry vectors driven by the cytomegalovirus (CMV) promoter, CGRP promoter, TRPV1 promoter or neurofilament 200 (NF200) promoter...
September 20, 2017: Neuroscience
https://www.readbyqxmd.com/read/28942073/update-on-the-management-of-infectious-keratitis
#6
REVIEW
Ariana Austin, Tom Lietman, Jennifer Rose-Nussbaumer
Infectious keratitis is a major global cause of visual impairment and blindness, often affecting marginalized populations. Proper diagnosis of the causative organism is critical, and although culture remains the prevailing diagnostic tool, newer techniques such as in vivo confocal microscopy are helpful for diagnosing fungus and Acanthamoeba. Next-generation sequencing holds the potential for early and accurate diagnosis even for organisms that are difficult to culture by conventional methods. Topical antibiotics remain the best treatment for bacterial keratitis, and a recent review found all commonly prescribed topical antibiotics to be equally effective...
September 20, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28941319/donor-derived-kaposi-s-sarcoma-in-a-liver-kidney-transplant-recipient
#7
S C Dollard, D Douglas, S V Basavaraju, D S Schmid, M Kuehnert, B Aqel
Human herpes virus 8 (HHV-8), also known as Kaposi's sarcoma associated herpesvirus (KSHV), is an oncogenic virus that can cause Kaposi's sarcoma (KS). KS can develop following organ transplantation through reactivation of the recipient's latent HHV-8 infection, or less commonly through donor-derived infection which has higher risk for severe illness and mortality. We describe a case of probable donor-derived KS in the recipient of a liver-kidney transplant. The donor had multiple risk factors for HHV-8 infection...
September 23, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28940695/herpes-zoster-in-kidney-transplant-recipients-protective-effect-of-anti-cmv-prophylaxis-and-nk-cells-count-a-single-center-cohort-study
#8
Mario Fernández-Ruiz, Julia Origüen, David Lora, Francisco López-Medrano, Esther González, Natalia Polanco, Rafael San Juan, Tamara Ruiz-Merlo, Patricia Parra, Amado Andrés, José María Aguado
Despite its impact on quality of life and potential for complications, specific risk and protective factors for herpes zoster (HZ) after kidney transplantation (KT) remain to be clarified. We included 444 patients undergoing KT between November 2008 and March 2013. Peripheral blood lymphocyte subpopulations were measured at baseline and months 1 and 6. The risk factors for early (first post-transplant year) and late HZ (years 1 to 5) were separately assessed. We observed 35 episodes of post-transplant HZ after a median follow-up of 48...
September 22, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28940544/chronic-granulomatous-dermatitis-induced-by-talimogene-laherparepvec-therapy-of-melanoma-metastases
#9
Ashlyn S Everett, Peter G Pavlidakey, Carlo M Contreras, Jennifer F De Los Santos, Ju Y Kim, Svetlana B McKee, Howard L Kaufman, Robert M Conry
Talimogene laherparepvec is the first oncolytic viral immunotherapy approved by the FDA, for advanced melanoma consisting of genetically modified herpes simplex type 1 virus which selectively replicates causing tumor lysis, expressing GM-CSF and activating dendritic cells. Intratumoral injection of TVEC produces objective response in 41% of stage IIB-IV M1a melanoma. However, clinical response assessments can be problematic due to immune-related inflammation at established tumor sites. Herein, we report 5 cases of granulomatous dermatitis developing at sites of TVEC injection associated with pathologic complete response in 4 of 5 patients...
September 22, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28940227/rapid-development-of-cutaneous-melanoma-metastases-after-herpes-zoster-infection-in-a-radiotherapy-field
#10
U Uslu, S Schliep, M Erdmann
No abstract text is available yet for this article.
September 23, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28939476/recurrent-herpetic-keratitis-despite-antiviral-prophylaxis-a-virological-and-pharmacological-study
#11
Antoine Rousseau, David Boutolleau, Karine Titier, Tristan Bourcier, Christophe Chiquet, Michel Weber, Joseph Colin, Julie Gueudry, Mohamed M'Garrech, Bahram Bodaghi, Sonia Burrel, Henri Agut, Claire Deback, Marc Labetoulle
Recurrent herpes simplex keratitis (HSK) is a leading infectious cause of blindness in industrialized countries. Antiviral prophylaxis (AVP) may fail to prevent recurrence of HSK due to viral resistance, inadequate dosing, or poor patient compliance. In this prospective multicenter study, we enrolled immunocompetent patients with recurrent HSK despite AVP. Ocular samples were tested by PCR for herpes simplex virus 1 (HSV-1). HSV-1 drug resistance was assessed with a genotypic assay based on UL23 and UL30 gene sequencing...
September 19, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28939451/hla-haploidentical-stem-cell-transplant-with-pre-transplant-immunosuppression-for-patients-with-sickle-cell-disease
#12
Anna B Pawlowska, Jerry C Cheng, Nicole A Karras, Weili Sun, Leo D Wang, Alison D Bell, Lisa Gutierrez, Joseph Rosenthal
Allogeneic stem cell transplantation (HCT) is curative in patients with severe sickle cell disease (SCD) but a significant number of patients lack a HLA-identical sibling or matched unrelated donor. Mismatched related (haploidentical) HCT with post-transplant cyclophosphamide (PTCY) allows expansion of the donor pool but is complicated by high rates of graft failure. In this report, we describe a favorable haploidentical HCT approach in a limited cohort of sickle cell patients with significant co-morbidities...
September 19, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28938221/-1-h-magnetic-resonance-spectroscopy-suggests-neural-membrane-alteration-in-specific-regions-involved-in-obsessive-compulsive-disorder
#13
Laura Hatchondo, Nematollah Jaafari, Nicolas Langbour, Sylvie Maillochaud, Guillaume Herpe, Rémy Guillevin, Carole Guillevin
No abstract text is available yet for this article.
September 14, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28937540/herpes-simplex-virus-esophagitis-in-immunocompetent-children-a-harbinger-of-eosinophilic-esophagitis
#14
Julia Fritz, Diana Lerner, Mariko Suchi
Herpes simplex virus (HSV) is a common cause of infectious esophagitis. The aim of this retrospective study is to identify comorbid and predisposing conditions and sequelae of HSV esophagitis in immunocompetent children. We reviewed sixteen cases of HSV esophagitis diagnosed from January, 1982 to March, 2016. Five patients were immunosuppressed, 11 were immunocompetent and included in the study. Three (27%) had no other significant medical history. Five patients (45%) had repeat biopsies following their HSV infection which showed eosinophilic infiltrate consistent with current diagnostic criteria of eosinophilic esophagitis (EoE), one of whom had known EoE...
September 20, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28937369/study-of-association-of-epstein-barr-virus-in-lymphomas-by-epstein-barr-virus-encoded-rna-in-situ-hybridization-an-indian-perspective-from-a-tertiary-care-cancer-institute
#15
Roshani Gala, Jatin S Gandhi, Gurudutt Gupta, Shrruti K Grover, Anila Sharma, Sunil Pasricha, Anurag Mehta
BACKGROUND: The Epstein-Barr virus (EBV), also called human herpesvirus 4, is a virus of the herpes family. The EBV-associated lymphomas include Burkitt lymphoma, classic Hodgkin lymphoma (HL), lymphomas arising in immunocompromised individuals, peripheral T-cell lymphomas, angioimmunoblastic T-cell lymphoma, extranodal nasal-type natural killer/T-cell lymphoma, and other rare histotypes. OBJECTIVE: The present study evaluated the role of EBV as an etiologic agent in various lymphomas and determined an Indian perspective in a tertiary care cancer center compared to that of Western literature...
July 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28936707/immunoglobulin-genotypes-and-cognitive-functions-in-schizophrenia
#16
Janardan P Pandey, Aryan M Namboodiri, Paul J Nietert, Reiji Yoshimura, Hikaru Hori
Exposure to neurotropic viruses, such as herpes simplex virus type 1 and human cytomegalovirus, has been reported to be associated with cognitive impairment in schizophrenia. These viruses have evolved highly sophisticated strategies for decreasing the efficacy of the host immune response and interfering with viral clearance. Particular immunoglobulin GM (γ marker) genotypes modulate these viral immunoevasion strategies, influence antibody responsiveness to viral proteins, and are also associated with susceptibility to schizophrenia, providing an excellent rationale for determining their possible involvement in the cognitive functions in this highly heritable neurodevelopmental disorder...
September 22, 2017: Immunogenetics
https://www.readbyqxmd.com/read/28936074/syndromes-of-rapidly-progressive-cognitive-decline-our-experience
#17
Sadanandavalli Retnaswami Chandra, Lakshminarayanapuram Gopal Viswanathan, Anupama Ramakanth Pai, Rahul Wahatule, Suvarna Alladi
BACKGROUND: Dementias are fairly slowly progressive degenerative diseases of brain for which treatment options are very less and carry a lot of burden on family and society. A small percentage of them are rapidly progressive and mostly carry a different course outcome. However, there are no definite criteria other than the time line for these patients. AIMS: The aim of this was to identify and categorize the causes and course of rapidly progressive dementias seen in our center...
August 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28934778/the-effect-of-early-use-of-supplemental-therapy-on-preventing-postherpetic-neuralgia-a-systematic-review-and-meta-analysis
#18
Xiu-Fang Xing, Zhen-Feng Zhou, Feng-Jiang Zhang, Min Yan
BACKGROUND: Postherpetic neuralgia (PHN) is the most common and refractory complication of herpes zoster (HZ). Aggressive treatment of acute pain in HZ has the potential to prevent the development of PHN, but the preventive efficacy of supplemental therapy commonly used in clinical practice is controversial. OBJECTIVES: Our aim is to examine the efficacy of supplemental therapy in preventing PHN. STUDY DESIGN: A meta-analysis. SETTING: All of the selected studies are randomized controlled trials (RCTs)...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28933622/risk-and-impact-of-herpes-zoster-on-patients-with-diabetes-a-population-based-study-2009-2014
#19
Cintia Muñoz-Quiles, Mónica López-Lacort, F Javier Ampudia-Blasco, Javier Díez-Domingo
AIMS: This study was designed to assess the impact of diabetes on the risk and severity of herpes zoster (HZ), and the impact of HZ on diabetes. It focused primarily on immunocompetent patients aged ≥ 50 years who would be eligible for preventive vaccination. METHODS: Using population and healthcare databases of Valencia Region (Spain), a retrospective cohort of all subjects ≥ 50 years was followed up between 2009 and 2014. HZ and diabetes were defined using ICD-9 codes...
September 21, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28933221/neural-stem-cell-transplantation-is-associated-with-inhibition-of-apoptosis-bcl-xl-upregulation-and-recovery-of-neurological-function-in-a-rat-model-of-traumatic-brain-injury
#20
Ai-Lan Pang, Liu-Lin Xiong, Qing-Jie Xia, Fen Liu, You-Cui Wang, Fei Liu, Piao Zhang, Bu-Liang Meng, Sheng Tan, Ting-Hua Wang
Traumatic brain injury (TBI) is a common disease that usually causes severe neurological damage, and current treatment is far from satisfactory. The neuroprotective effects of neural stem cell (NSC) transplantation in the injured nervous system have largely been known, but the underlying mechanisms remain unclear, and their limited sources impede their clinical application. Here, we established a rat model of TBI by dropping a weight onto the cortical motor area of the brain and explored the effect of engrafted NSCs (passage 3, derived from the hippocampus of embryonic 12- to 14-d green fluorescent protein transgenic mice) on TBI rats...
July 2017: Cell Transplantation
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