H Szwed, Z Sadowski, R Pachocki, M Domzał-Bocheńska, K Szymczak, Z Szydłowski, A Paradowski, G Gajos, G Kałuza, I Kulon, A Wator-Brzezińska, W Elikowski, M Kuźniak
Diabetes mellitus, a disease with a wide prevalence, has major cardiovascular effects, being a risk factor for the development of ischemic heart disease and congestive heart failure. The aim of this open, multicenter study was to assess the antiischemic efficacy and tolerability of trimetazidine, a metabolic agent acting at the myocardial mitochondrial level, in diabetic patients with stable effort angina treated previously with a single conventional antianginal drug. Fifty diabetic patients (mean age 58 years) with proven coronary artery disease, stable effort angina for at least 3 months, and positive, comparable results of two initial treadmill exercise tests separated by a 1-week interval were included in the study...
May 1999: Cardiovascular Drugs and Therapy