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https://www.readbyqxmd.com/read/29228302/susceptibility-of-hla-e-01-03-allele-carriers-to-develop-cytomegalovirus-replication-after-living-donor-kidney-transplantation
#1
Hana Guberina, Fabiola da Silva Nardi, Rafael Tomoya Michita, Sebastian Dolff, Anja Bienholz, Falko M Heinemann, Benjamin Wilde, Mirko Trilling, Peter A Horn, Andreas Kribben, Oliver Witzke, Vera Rebmann
Cytomegalovirus (CMV) causes serious complications among solid-organ transplant recipients. We report the positive correlation between the presence of the Human Leukocyte Antigen (HLA)-E*01:03 allele in living-donor kidney recipients and CMV reactivation during the first year after transplantation. Thus, the HLA-E recipient genotyping may help to identify CMV-prone patients who require individualized patient-based CMV management.
December 8, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29228112/xenotransplantation-the-current-status-and-prospects
#2
D K C Cooper, R Gaston, D Eckhoff, J Ladowski, T Yamamoto, L Wang, H Iwase, H Hara, M Tector, A J Tector
Introduction: There is a continuing worldwide shortage of organs from deceased human donors for transplantation into patients with end-stage organ failure. Genetically engineered pigs could resolve this problem, and could also provide tissues and cells for the treatment of conditions such as diabetes, Parkinson's disease and corneal blindness. Sources of data: The current literature has been reviewed. Areas of agreement: The pathobiologic barriers are now largely defined...
December 8, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/29228016/prevalence-and-molecular-profiling-of-epstein-barr-virus-ebv-among-healthy-blood-donors-from-different-nationalities-in-qatar
#3
Maria K Smatti, Hadi M Yassine, Raed AbuOdeh, Asmaa AlMarawani, Sara A Taleb, Asmaa A Althani, Gheyath K Nasrallah
BACKGROUND: The Epstein-Barr virus (EBV) is the causative agent of infectious mononucleosis. EBV is highly prevalent lymphotropic herpesvirus and has been linked to several malignancies. Transmission is generally by oral secretions, but can be through blood transfusions and organ transplantations. This study aimed to determine the seroprevalence, viremia rates, and circulating genotypes of EBV in healthy blood donors in Qatar. METHODS: Blood samples from 673 blood donors of different nationalities residing in Qatar (mainly Qatar, Egypt, Syria, Jordan, Pakistan, and India) were collected and tested for anti-EBV capsid (VCA; IgG & IgM), nuclear (EBNA; IgG), and early (EA-D; IgG) antigens...
2017: PloS One
https://www.readbyqxmd.com/read/29227984/microrna-146b-5p-identified-in-porcine-liver-donation-model-is-associated-with-early-allograft-dysfunction-in-human-liver-transplantation
#4
Cheukfai Li, Qiang Zhao, Wei Zhang, Maogen Chen, Weiqiang Ju, Linwei Wu, Ming Han, Yi Ma, Xiaofeng Zhu, Dongping Wang, Zhiyong Guo, Xiaoshun He
BACKGROUND Poor transplant outcome was observed in donation after brain death followed by circulatory death (DBCD), since the donor organs suffered both cytokine storm of brain death and warm ischemia injury. MicroRNAs (miRNAs) have emerged as promising disease biomarkers, so we sought to establish a miRNA signature of porcine DBCD and verify the findings in human liver transplantation. MATERIAL AND METHODS MiRNA expression was determined with miRNA sequencing in 3 types of the porcine model of organ donation, including donation after brain death (DBD) group, donation after circulatory death (DCD) group, and DBCD group...
December 11, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29227494/the-crucial-role-of-a-spacer-material-on-the-efficiency-of-charge-transfer-processes-in-organic-donor-acceptor-junction-solar-cells
#5
Reed Nieman, Hsinhan Tsai, Wanyi Nie, Adelia J A Aquino, Aditya D Mohite, Sergei Tretiak, Hao Li, Hans Lischka
Organic photovoltaic donor-acceptor junction devices composed of π-conjugated polymer electron donors (D) and fullerene electron acceptors (A) show greatly increased performance when a spacer material is inserted between the two layers (W. Y. Nie, G. Gupta, B. K. Crone, F. L. Liu, D. L. Smith, P. P. Ruden, C. Y. Kuo, H. Tsai, H. L. Wang, H. Li, S. Tretiak and A. D. Mohite, Adv. Sci., 2015, 2, 1500024.). For instance, experimental results reveal significant improvement of photocurrent when a terthiophene oligomer derivative is inserted in between π-conjugated poly(3-hexylthiophene-2,5-diyl) (P3HT) donor and C60 acceptor...
December 11, 2017: Nanoscale
https://www.readbyqxmd.com/read/29227091/a-vuv-excited-and-ch2cl2-h2o-amplified-ionization-coupled-mass-spectrometry-for-oxygenated-organics-analysis
#6
Bo Yang, Haixu Zhang, Jinian Shu, Pengkun Ma, Peng Zhang, Jingyun Huang, Zhen Li, Ce Xu
The mass spectrometry analysis of oxygenated volatile organic compounds (OVOCs) remains challenging due to their limited ionization efficiencies. In this study, we surprisingly found that, under VUV excitation, a gaseous mixture of CH2Cl2/H2O/analyte (OVOCs) in N2 buffer generated large amounts of H3O+ and protonated analyte even when the photon energy was lower than the ionization energy of the neutral species involved. In contrast to those obtained with VUV photoionization alone, the signal intensities of oxygenated organics can be amplified by more than three orders of magnitude...
December 11, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29227038/molecular-design-of-efficient-organic-d-a-%C3%AF-a-dye-featuring-triphenylamine-as-donor-fragment-for-application-in-dye-sensitized-solar-cells
#7
Anders Hagfeldt, Parnian Ferdowsi, Yasemin Saygili, Weiwei Zhang, Tomas Edvinsson, Ladislav Kavan, Javad Mokhtari, Shaik M Zakeeruddin, Michael Grätzel
We designed, synthesized and characterized a novel metal-free organic sensitizer, suitable for the application in dye-sensitized solar cells (DSSCs), both experimentally and theoretically. The structure of the novel donor-acceptor-π-bridge-acceptor (D-A-π-A) dye has triphenylamine (TPA) segment and 4-(Benzo[c][1,2,5] thiadiazol-4-ylethynyl) benzoic acid (BTEBA). The triphenylamine unit is widely used as electron donor for the photosensitizers due to its outstanding characteristics, i.e. the non-planar molecular configuration and excellent electron donating capability while 4-(Benzo[c][1,2,5] thiadiazol-4-ylethynyl) benzoic acid is used as electron acceptor unit...
December 11, 2017: ChemSusChem
https://www.readbyqxmd.com/read/29226765/never-declared-brain-dead-potential-organ-donors-an-additional-source-of-donor-organs
#8
Patricia A Webster, Lori E Markham
CONTEXT: Patients never declared brain dead may represent an additional source of donor organs. OBJECTIVE: To determine the number of likely brain dead potential donors who are never declared brain dead and to compare them with brain dead and donation after cardiac death potential organ donors. DESIGN, SETTING, AND PARTICIPANTS: This study was a retrospective chart review of all catastrophically brain-injured patients referred to a single-organ procurement organization (OPO) over a 4-year period...
January 1, 2017: Progress in Transplantation
https://www.readbyqxmd.com/read/29226102/timing-of-hepatitis-c-virus-treatment-in-liver-transplant-candidates-in-the-era-of-direct-acting-antiviral-agents
#9
REVIEW
George Cholankeril, Mairin Joseph-Talreja, Brandon J Perumpail, Andy Liu, Eric R Yoo, Aijaz Ahmed, Aparna Goel
Chronic hepatitis C virus (HCV) infection remains the leading indication for liver transplantation (LT) in the United States. While most patients with chronic HCV infection remain asymptomatic, up to one-third develop progressive liver disease resulting in cirrhosis. LT is often the only curative treatment once significant hepatic decompensation develops. However, antiviral therapy for HCV infection has advanced markedly in the past 5 years with the discovery and approval of direct-acting antiviral agents. These new regimens are well tolerated, of short duration and highly effective, unlike the traditional treatment with pegylated-interferon and ribavirin...
December 28, 2017: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/29225610/horizontal-gene-transfer-contributes-to-plant-evolution-the-case-of-agrobacterium-t-dnas
#10
REVIEW
Dora G Quispe-Huamanquispe, Godelieve Gheysen, Jan F Kreuze
Horizontal gene transfer (HGT) can be defined as the acquisition of genetic material from another organism without being its offspring. HGT is common in the microbial world including archaea and bacteria, where HGT mechanisms are widely understood and recognized as an important force in evolution. In eukaryotes, HGT now appears to occur more frequently than originally thought. Many studies are currently detecting novel HGT events among distinct lineages using next-generation sequencing. Most examples to date include gene transfers from bacterial donors to recipient organisms including fungi, plants, and animals...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29225129/hydrogen-sulfide-as-a-regulatory-factor-in-kidney-health-and-disease
#11
REVIEW
Balakuntalam S Kasinath, Denis Feliers, Hak Joo Lee
Hydrogen sulfide (H2S) is synthesized in nearly all organ systems including the kidney. Recent findings have revealed that H2S functions as a gasotransmitter affecting a wide range of physiologic functions similar to other gasotransmitters nitric oxide (NO) and carbon monoxide (CO). Research on H2S regulation of kidney function is still in early stages. H2S increases glomerular filtration rate (GFR) and inhibits sodium absorption by the tubules. There is burgeoning evidence that H2S generation by kidney cells is reduced in acute and chronic disease states and that H2S donors ameliorate injury...
December 7, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29224818/reconstruction-after-salvage-laryngectomy
#12
David H Yeh, Axel Sahovaler, Kevin Fung
Both early and advanced stage laryngeal cancers are treated with organ-preserving strategies including radiation alone or concurrent chemoradiotherapy. While organ-preserving modalities have proven effective in eradicating cancer while also preserving laryngeal function, there remains a proportion of cases where residual or recurrent cancer prevails, or conversely, where radiotherapy renders a larynx dysfunctional. In these circumstances, salvage total laryngectomy is often the surgical treatment. The effects of radiotherapy to the neck, amplified by chemotherapy, can create an inhospitable surgical environment, making the salvage laryngectomy an operation fraught with the potential for major complications such as the dreaded pharyngocutaneous fistula...
December 2017: Oral Oncology
https://www.readbyqxmd.com/read/29223868/recirculation-of-gas-emissions-to-achieve-advanced-denitrification-of-the-effluent-from-the-anaerobic-treatment-of-domestic-wastewater
#13
L Pelaz, A Gómez, G Garralón, A Letona, M Fdz-Polanco
A denitrifying pilot plant was designed, constructed and operated for more than five months. The plant treated domestic wastewater with high ammonium nitrogen concentration, which had previously undergone an anaerobic process at 18 °C. The process consisted of one biofilter with 2 h of hydraulic retention time for denitritation. Different synthetic nitrite concentrations were supplied to the anoxic reactor to simulate the effluent of a nitritation process. This work investigates the advanced denitritation of wastewater using the organic matter and other alternative electron donors present in an anaerobic treatment process effluent: methane and sulfide...
December 7, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29222929/hiv-deceased-donor-referrals-a-national-survey-of-organ-procurement-organizations
#14
Ayla Cash, Xun Luo, Eric K H Chow, Mary Grace Bowring, Ashton A Shaffer, Brianna Doby, Corey E Wickliffe, Charles Alexander, Deborah McRann, Aaron A R Tobian, Dorry L Segev, Christine M Durand
BACKGROUND: HIV-infected (HIV+) donor organs can be transplanted into HIV+ recipients under the HIV Organ Policy Equity (HOPE) Act. Quantifying HIV+ donor referrals received by Organ Procurement Organizations (OPOs) is critical for HOPE Act implementation. METHODS: We surveyed the 58 US OPOs regarding HIV+ referral records and newly discovered HIV+ donors. Using data from OPOs that provided exact records and CDC HIV prevalence data, we projected a national estimate of HIV+ referrals...
December 9, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/29222916/transplanting-hcv-positive-livers-into-hcv-negative-patients-with-preemptive-antiviral-treatment-a-modeling-study
#15
Jagpreet Chhatwal, Sumeyye Samur, Emily D Bethea, Turgay Ayer, Fasiha Kanwal, Chin Hur, Mark S Roberts, Norah Terrault, Raymond T Chung
Under current guidelines hepatitis C virus (HCV)-positive livers are not transplanted into HCV-negative recipients because of adverse post-transplant outcomes associated with allograft HCV infection. However, HCV can now be cured post liver transplant (LT) using direct-acting antivirals (DAAs) with >90% success; therefore, HCV-negative patients on the liver transplant (LT) waiting list may benefit from accepting HCV-positive organs with preemptive treatment. Our objective was to evaluate if and in which HCV-negative patients the potential benefit of accepting an HCV-positive (i...
December 9, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29222267/new-therapeutic-targets-in-transfusion-dependent-and-independent-thalassemia
#16
REVIEW
M Domenica Cappellini, Irene Motta
β-Thalassemias are characterized by reduced production of β-globin chain, resulting in α/β-chain unbalance and precipitation of α-globin-heme complexes and determining ineffective erythropoiesis. Ineffective erythropoiesis, chronic hemolytic anemia, and compensatory hematopoietic expansion are the disease hallmarks, and they are related to the severity of the chain unbalance. Several clinical forms of β-thalassemia, including the coinheritance of β-thalassemia with hemoglobin E resulting in hemoglobin E/β-thalassemia, have been described...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29221886/a-model-including-sarcopenia-surpasses-the-meld-score-in-predicting-waiting-list-mortality-in-cirrhotic-liver-transplant-candidates
#17
Jeroen Laurens Ad van Vugt, Louise Johanna Maria Alferink, Stefan Buettner, Marcia Patricia Gaspersz, Daphne Bot, Sarwa Darwish Murad, Shirin Feshtali, Peter Martinus Adranius van Ooijen, Wojciech Grzegorz Polak, Robert Jan Porte, Bart van Hoek, Aad Pieter van den Berg, Herold Johnny Metselaar, Jan Nicolaas Maria IJzermans
BACKGROUND AND AIMS: Frail patients with low MELD scores may be underprioritised. Low skeletal muscle mass (i.e. sarcopenia) has been identified as risk factor for waiting list mortality and a recent study proposed to incorporate sarcopenia in the MELD score (i.e. MELD-Sarcopenia score). We aimed to investigate the association between sarcopenia and waiting list mortality, and to validate the MELD-Sarcopenia score (i.e. MELD+10.35∗Sarcopenia). METHODS: We identified consecutive patients with cirrhosis listed for liver transplantation in the Eurotransplant registry between 2007-2014 and measured skeletal muscle mass on computed tomography (CT)...
December 5, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/29221464/molecular-and-functional-characterization-of-ferredoxin-nadp-h-oxidoreductase-from-gracilaria-chilensis-and-its-complex-with-ferredoxin
#18
María Alejandra Vorphal, Carola Bruna, Traudy Wandersleben, Jorge Dagnino-Leone, Francisco Lobos-González, Elena Uribe, José Martínez-Oyanedel, Marta Bunster
BACKGROUD: Ferredoxin NADP(H) oxidoreductases (EC 1.18.1.2) (FNR) are flavoenzymes present in photosynthetic organisms; they are relevant for the production of reduced donors to redox reactions, i.e. in photosynthesis, the reduction of NADP+ to NADPH using the electrons provided by Ferredoxin (Fd), a small FeS soluble protein acceptor of electrons from PSI in chloroplasts. In rhodophyta no information about this system has been reported, this work is a contribution to the molecular and functional characterization of FNR from Gracilaria chilensis, also providing a structural analysis of the complex FNR/Fd...
December 8, 2017: Biological Research
https://www.readbyqxmd.com/read/29221392/spectroscopic-and-theoretical-studies-on-the-structural-electronic-and-optical-properties-of-zinc-octaethylporphyrin-c60-co-deposited-films
#19
Jun Onoe, Shinta Watanabe, Shiro Kato, Masato Nakaya, Jean-Pierre Bucher
We have examined the structural, electronic, and optical properties of zinc-octaethylporphyrin [Zn(OEP)]/C60 co-deposited films to elucidate the donor (D)-acceptor (A) interactions at the D/A interface of heterojunction organic solar cells (OSCs), using Fourier-transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), ultraviolet-visible (UV-vis) spectroscopy, and photoluminescence (PL) spectroscopy in combination with first-principles and semi-empirical calculations. The FT-IR and XRD results indicated that Zn(OEP) and C60 were mixed with each other at the molecular level in the co-deposited film...
December 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29221320/bridging-to-lung-transplantation-with-extracorporeal-circulatory-support-when-or-when-not
#20
REVIEW
Gabriel Loor, Leo Simpson, Amit Parulekar
Patients with end-stage lung disease who are candidates for lung transplantation may acutely decompensate before a donor organ becomes available. In this scenario, extracorporeal life support (ECLS) may be considered as a bridge to transplant or as a bridge to decision. In the current chapter, we review the indications, techniques, and outcomes for bridging to lung transplantation with ECLS.
September 2017: Journal of Thoracic Disease
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