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https://www.readbyqxmd.com/read/28088732/apelin-13-protects-rat-primary-cortical-glia-neuron-co-culture-against-pentylenetetrazole-induced-toxicity
#1
Taj Pari Kalantaripour, Saeed Esmaeili-Mahani, Vahid Sheibani, Hamid Najafipour, Majid Asadi-Shekaari M
In spite of recent advances in the treatment of epilepsy, up to 35% of people living with the condition do not respond to accessible anti-epileptic drugs (AEDs) and continue to experience regular, devastating and potentially life-threatening seizures. Neuronal death is a significant feature of epilepsy in humans and experimental models. It has been reported that apelin, an endogenous ligand for the angiotensin-1-like receptor (APJ), has anticonvulsive as well as protective effects in some neurodegenerative situations...
January 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28088209/pulmonary-embolism-in-non-brain-tumor-patients-after-surgery-a-retrospective-study-in-china
#2
Ren-Xiong Chen, Hong-Zhi Wang, Jun Dong, Hong Ren, Xiao-Jie Chen, Jia-Xuan Xu, Yong Yang, Guo-Dong Wang
BACKGROUND: The incidence rate of pulmonary emboli (PE) is high in tumor patients; however, the morbidity and mortality associated with the development of PE after tumor surgery are unknown. We studied the clinical profiles and outcomes of patients with PE after non-brain tumor surgery. METHODS: We retrospectively screened 55,967 patients who underwent non-brain tumor surgery at the Peking University Cancer Hospital from January 2008 to June 2015. Among them, 76 patients who were diagnosed with PE were enrolled in our study...
January 14, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28087833/dysregulation-of-map-kinase-signaling-pathways-including-p38mapk-sapk-jnk-and-erk1-2-in-cultured-rat-cerebellar-astrocytes-exposed-to-diphenylarsinic-acid
#3
Takayuki Negishi, Mami Matsumoto, Yayoi Kobayashi, Mikiya Kojima, Fumika Sakaguchi, Kazuaki Takahata, Tomoko Kanehira, Rina Arakaki, Yohei Aoyama, Hikari Yoshida, Rena Yamada, Nobutaka Sumiyoshi, Tomoko Tashiro, Seishiro Hirano, Kenji Yoshida, Kazunori Yukawa
Diphenylarsinic acid (DPAA) was a major compound found in the arsenic poisoning incident that occurred in Kamisu, Ibaraki, Japan in 2003. People exposed to DPAA via contaminated well water suffered from several neurological disorders, including cerebellar symptoms. We previously reported that DPAA induces cellular activation in cultured rat cerebellar astrocytes, dose-dependent promotion of cell growth (low DPAA), cell death (high DPAA), and increased phosphorylation of mitogen-activated protein (MAP) kinases (p38MAPK, SAPK/JNK, and ERK1/2)...
January 13, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28087824/neuropathology-of-sudep-role-of-inflammation-blood-brain-barrier-impairment-and-hypoxia
#4
Zuzanna Michalak, Dima Obari, Matthew Ellis, Maria Thom, Sanjay M Sisodiya
OBJECTIVE: To seek a neuropathologic signature of sudden unexpected death in epilepsy (SUDEP) in a postmortem cohort by use of immunohistochemistry for specific markers of inflammation, gliosis, acute neuronal injury due to hypoxia, and blood-brain barrier (BBB) disruption, enabling the generation of hypotheses about potential mechanisms of death in SUDEP. METHODS: Using immunohistochemistry, we investigated the expression of 6 markers (CD163, human leukocyte antigen-antigen D related, glial fibrillary acid protein, hypoxia-inducible factor-1α [HIF-1α], immunoglobulin G, and albumin) in the hippocampus, amygdala, and medulla in 58 postmortem cases: 28 SUDEP (definite and probable), 12 epilepsy controls, and 18 nonepileptic sudden death controls...
January 13, 2017: Neurology
https://www.readbyqxmd.com/read/28080901/cerebellar-and-mesencephalon-neoplasia-in-a-nile-hipoppotamus-hippopotamus-amphibious
#5
Francesca Schiaffino, Samantha J Sander, Marcia E Pereira Bacares, Katie J Barnes, Matti Kiupel, Timothy Walsh, Suzan Murray
A 52-yr-old female Nile hippopotamus ( Hippopotamus amphibious ) was presented for acute onset anorexia, depression, lethargy, instability, and weakness in the pelvic limbs. Clinical signs were rapidly progressive, despite empiric therapy with anti-inflammatory medications, resulting in the death of the animal. Gross necropsy evaluation revealed two tan, firm masses in the cerebellum and mesencephalon and a single mass in the right cranial adrenal gland. All three masses had a similar histologic morphology, and immunohistochemical investigation confirmed the general diagnosis of an adenocarcinoma, but the exact cell of origin remains unclear...
December 2016: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28079995/effects-of-cell-cycle-phases-on-the-induction-of-dental-pulp-stem-cells-toward-dopaminergic-like-cells
#6
Nareshwaran Gnanasegaran, Vijayendran Govindasamy, Premasangery Kathirvaloo, Sabri Musa, Noor Hayaty Abu Kasim
Parkinson's disease (PD) is characterized by tremors and cognitive issues, and is due to the death of dopaminergic (DA-ergic) neurons in brain circuits that are responsible for producing neurotransmitter dopamine (DA). Currently, cell replacement therapies are underway to overcome existing therapeutic approaches such as drug treatments and electrical stimulation. Among the widely available sources, dental pulp stem cells from deciduous teeth (DPSC) have gained popularity due to their neural crest origin and inherent propensity toward neuronal lineage...
January 12, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28079889/deletion-of-the-bh3-only-protein-noxa-alters-electrographic-seizures-but-does-not-protect-against-hippocampal-damage-after-status-epilepticus-in-mice
#7
Naoki Ichikawa, Mariana Alves, Shona Pfeiffer, Elena Langa, Yasmina E Hernández-Santana, Hidenori Suzuki, Jochen Hm Prehn, Tobias Engel, David C Henshall
Several members of the Bcl-2 gene family are dysregulated in human temporal lobe epilepsy and animal studies show that genetic deletion of some of these proteins influence electrographic seizure responses to chemoconvulsants and associated brain damage. The BH3-only proteins form a subgroup comprising direct activators of Bax-Bak that are potently proapoptotic and a number of weaker proapoptotic BH3-only proteins that act as sensitizers by neutralization of antiapoptotic Bcl-2 family members. Noxa was originally characterized as a weaker proapoptotic, 'sensitizer' BH3-only protein, although recent evidence suggests it too may be potently proapoptotic...
January 12, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28079313/postischemic-inflammation-in-acute-stroke
#8
REVIEW
Simone Vidale, Arturo Consoli, Marco Arnaboldi, Domenico Consoli
Cerebral ischemia is caused by arterial occlusion due to a thrombus or an embolus. Such occlusion induces multiple and concomitant pathophysiological processes that involve bioenergetic failure, acidosis, loss of cell homeostasis, excitotoxicity, and disruption of the blood-brain barrier. All of these mechanisms contribute to neuronal death, mainly via apoptosis or necrosis. The immune system is involved in this process in the early phases after brain injury, which contributes to potential enlargement of the infarct size and involves the penumbra area...
January 2017: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/28079146/nitrosative-stress-induced-disruption-of-baroreflex-neural-circuits-in-a-rat-model-of-hepatic-encephalopathy-a-dti-study
#9
Ching-Yi Tsai, Chia-Hao Su, Julie Y H Chan, Samuel H H Chan
The onset of hepatic encephalopathy (HE) in liver failure is associated with high mortality; the underlying mechanism is undecided. Here we report that in an acute liver failure model employing intraperitoneal administration of thioacetamide in Sprague-Dawley rats, diffusion weighted imaging revealed a progressive reduction in apparent diffusion coefficient in the brain stem. Diffusion tensor imaging further showed that the connectivity between nucleus tractus solitarii (NTS), the terminal site of baroreceptor afferents in brain stem and rostral ventrolateral medulla (RVLM), the origin of sympathetic innervation of blood vessels, was progressively disrupted until its disappearance, coincidental with the irreversible cessation of baroreflex-mediated sympathetic vasomotor tone signifying clinically the occurrence of brain death...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28078616/physician-power-to-declare-death-by-neurologic-criteria-threatened
#10
Ariane Lewis, Thaddeus Mason Pope
BACKGROUND: Three recent lawsuits that address declaration of brain death (BD) garnered significant media attention and threaten to limit physician power to declare BD. METHODS: We discuss these cases and their consequences including: the right to refuse an apnea test, accepted medical standards for declaration of BD, and the irreversibility of BD. RESULTS: These cases warrant discussion because they threaten to: limit physicians' power to determine death; incite families to seek injunctions to continue organ support after BD; and force hospitals to dispense valuable resources to dead patients in lieu of patients with reparable illnesses or injuries...
January 11, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/28077579/neuron-enriched-rna-binding-proteins-regulate-pancreatic-beta-cell-function-and-survival
#11
Jon Agraves Juan-Mateu, Tatiana H Rech, Olatz Villate, Esther Lizarraga-Mollinedo, Anna Wendt, Jean-Valery Turatsinze, Leticia A Brondani, Tarlliza R Nardelli, Tatiane C Nogueira, Jonatan L S Esguerra, Maria In Ecircs Alvelos, Piero Marchetti, Lena Eliasson, D Eacutecio L Eizirik
Pancreatic beta cell failure is the central event leading to diabetes. Beta cells share many phenotypic traits with neurons, and proper beta cell function relies on the activation of several neuronal-like transcription programs. Regulation of gene expression by alternative splicing plays a pivotal role in brain, where it affects neuronal development, function and disease. The role of alternative splicing in beta cells remains unclear, but recent data indicate that splicing alterations modulated by both inflammation and susceptibility genes for diabetes contribute to beta cell dysfunction and death...
January 11, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28077490/improving-uniformity-in-brain-death-determination-policies-over-time
#12
Hilary H Wang, Panayiotis N Varelas, Galen V Henderson, Eelco F M Wijdicks, David M Greer
OBJECTIVE: To demonstrate that progress has been made in unifying brain death determination guidelines in the last decade by directly comparing the policies of the US News and World Report's top 50 ranked neurologic institutions from 2006 and 2015. METHODS: We solicited official hospital guidelines in 2015 from these top 50 institutions, generated summary statistics of their criteria as benchmarked against the American Academy of Neurology Practice Parameters (AANPP) and the comparison 2006 cohort in 5 key categories, and statistically compared the 2 cohorts' compliance with the AANPP...
January 11, 2017: Neurology
https://www.readbyqxmd.com/read/28077335/omega-3-fatty-acids-regulate-nlrp3-inflammasome-activation-and-prevent-behavior-deficits-after-traumatic-brain-injury
#13
Chao Lin, Honglu Chao, Zheng Li, Xiupeng Xu, Yinlong Liu, Zhongyuan Bao, Lijun Hou, Yan Liu, Xiaoming Wang, Yongping You, Ning Liu, Jing Ji
Omega-3 fatty acids (ω-3 FAs) attenuate inflammation and improve neurological outcome in response to traumatic brain injury (TBI), but the specific anti-inflammatory mechanisms remain to be elucidated. Here we found that NLRP3 inflammasome and subsequent pro-inflammatory cytokines were activated in human brains after TBI. Rats treated with ω-3 FAs had significantly less TBI-induced caspase-1 cleavage and IL-1β secretion than those with vehicle. G protein-coupled receptor 40 (GPR40) was observed to be involved in this anti-inflammation...
January 8, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28077334/the-neuroprotective-compound-p7c3-a20-promotes-neurogenesis-and-improves-cognitive-function-after-ischemic-stroke
#14
Zachary B Loris, Andrew A Pieper, W Dalton Dietrich
Ischemic stroke is a devastating condition with few therapeutic interventions available. The neuroprotective compound P7C3-A20 inhibits mature neuronal cell death while also increasing the net magnitude of postnatal neurogenesis in models of neurodegeneration and acute injury. P7C3 compounds enhance flux of nicotinamide adenine dinucleotide (NAD) in mammalian cells, a proposed therapeutic approach to treating cerebral ischemia. The effectiveness of P7C3-A20 treatment on chronic histopathological and behavioral outcomes and neurogenesis after ischemic stroke has not previously been established...
January 8, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28076432/development-of-a-humane-slaughter-device-for-green-turtles-for-use-by-traditional-owners-in-the-torres-strait-islands-australia
#15
Mark Flint, Paul C Mills, Frank Loban, Tristan Simpson, Stan Lui, Ronald Fujii, Don Whap, Jaylene B Flint, Helen Owen
Marine turtles are caught and slaughtered for consumption as part of traditional indigenous community harvest in Australia as well as in many countries in which marine turtles can be found. However, changes to the Animal Care and Protection Act 2001 in 2012 resulted in Australian indigenous hunters becoming potentially liable to prosecution for using traditional practices to slaughter marine turtles. To provide indigenous hunters with an alternative scientifically tested method to hunt, we developed and tested a humane method as an option to use in indigenous communities...
2017: PloS One
https://www.readbyqxmd.com/read/28074416/proceedings-of-r%C3%A3-animation-2017-the-french-intensive-care-society-international-congress
#16
Chtara Kamilia, Kais Regaieg, Najeh Baccouch, Hedi Chelly, Mabrouk Bahloul, Mounir Bouaziz, Ali Jendoubi, Ahmed Abbes, Houda Belhaouane, Oussama Nasri, Layla Jenzri, Salma Ghedira, Mohamed Houissa, Kamal Belkadi, Youness Harti, Afak Nsiri, Khalid Khaleq, Driss Hamoudi, Rachid Harrar, Camille Thieffry, Frédéric Wallet, Erika Parmentier-Decrucq, Raphaël Favory, Daniel Mathieu, Julien Poissy, Thomas Lafon, Philippe Vignon, Emmanuelle Begot, Alexandra Appert, Mathilde Hadj, Paul Claverie, Morgan Matt, Olivier Barraud, Bruno François, Amira Jamoussi, Amira Ben Jazia, Takoua Marhbène, Dhouha Lakhdhar, Jalila Ben Khelil, Mohamed Besbes, Julien Goutay, Caroline Blazejewski, Isabelle Joly-Durand, Isabelle Pirlet, Marie Pierre Weillaert, Sebastien Beague, Soufi Aziz, Reda Hafiane, Khalid Hattabi, Mohamed Aziz Bouhouri, Driss Hammoudi, Abdelaziz Fadil, Rachid Al Harrar, Khalid Zerouali, Fatma Kaaniche Medhioub, Rania Allela, Najla Ben Algia, Samar Cherif, Mohamed Taoufik Slaoui, Souhail Boubia, Y Hafiani, A Khaoudi, R Cherkab, W Elallam, C Elkettani, L Barrou, M Ridaii, Rihi El Mehdi, Caroline Schimpf, Assaf Mizrahi, Benoît Pilmis, Alban Le Monnier, Kelly Tiercelet, Mélanie Cherin, Cédric Bruel, Francois Philippart, Sébastien Bailly, Jc Lucet, Alain Lepape, François L'hériteau, Martine Aupée, Caroline Bervas, Sandrine Boussat, Anne Berger-Carbonne, Anaïs Machut, Anne Savey, Jean-François Timsit, Keyvan Razazi, Jérémy Rosman, Nicolas de Prost, Guillaume Carteaux, Chloe Jansen, Jean Winoc Decousser, Christian Brun-Buisson, Armand Mekontso Dessap, Aymen M'rad, Zouhour Ouali, Manel Barghouth, Achille Kouatchet, Rafael Mahieu, Emmanuel Weiss, David Schnell, Jean-Ralph Zahar, Margaux Artiguenave, Paktoris-Papine Sophie, Florence Espinasse, Faten El Sayed, Aurélien Dinh, Cyril Charron, Guillaume Geri, Antoine Vieillard-Baron, Xavier Repessé, Hatem Kallel, Claire Mayence, Stéphanie Houcke, Pascal Guegueniat, Didier Hommel, Kaouther Dhifaoui, Zied Hajjej, Amira Fatnassi, Walid Sellami, Iheb Labbene, Mustapha Ferjani, Fahmi Dachraoui, Sabrine Nakkaa, Abdelwaheb M'ghirbi, Ali Adhieb, Dhouha Ben Braiek, Kmar Hraiech, Ali Ousji, Islem Ouanes, Hammouda Zaineb, Saousen Ben Abdallah, Lamia Ouanes-Besbes, Fekri Abroug, Simon Klein, Mattéo Miquet, Jean-Marc Thouret, Vincent Peigne, Jean-Louis Daban, Mathieu Boutonnet, Bernard Lenoir, Takoua Merhbene, Celine Derreumaux, Thierry Seguin, Jean-Marie Conil, Charlotte Kelway, Valery Blasco, Cyril Nafati, Karim Harti, Laurent Reydellet, Jacques Albanese, Narjess Ben Aicha, Khaoula Meddeb, Ahmed Khedher, Jihene Ayachi, Nesrine Fraj, Nesrine Sma, Imed Chouchene, Mohamed Boussarsar, Soumaya Ben Yedder, Walid Samoud, Bousselmi Radhouene, Bousselmi Mariem, Asma Ammar, Asma Ben Cheikh, Hend Ben Lakhal, Messaouda Khelfa, Yamina Hamdaoui, Nabiha Bouafia, Timothée Trampont, Thomas Daix, Vincent Legarçon, Henri Hani Karam, Nicolas Pichon, Fatma Essafi, Nasreddine Foudhaili, Hafedh Thabet, Youssef Blel, Nozha Brahmi, Hanane Ezzouine, Mahmoud Kerrous, Saad El Haoui, Soufiane Ahdil, Abdellatif Benslama, Khalid Abidi, Tarek Dendane, Ssouni Oussama, Jihane Belayachi, Naoufal Madani, Redouane Abouqal, Amine Ali Zeggwagh, Hatem Ghadhoune, Anis Chaari, Guissouma Jihene, Hend Allouche, Insaf Trabelsi, Habib Brahmi, Mohamed Samet, Hatem El Ghord, Ben Sik Ali Habiba, Nouira Hajer, Najla Tilouch, Sondes Yaakoubi, Oussama Jaoued, Rim Gharbi, Mohamed Fekih Hassen, Souheil Elatrous, Julien Arcizet, Bertrand Leroy, Caroline Abdulmalack, Catherine Renzullo, Maël Hamet, Jean-Marc Doise, Jérôme Coutet, Chaigar Mohammed Cheikh, Zakaria Quechar, Magalie Joris, Dimitri Titeca Beauport, Loay Kontar, Delphine Lebon, Bérengère Gruson, Michel Slama, Jean-Pierre Marolleau, Julien Maizel, Julie Gorham, Lieveke Ameye, Thierry Berghmans, Marianne Paesmans, Jean-Paul Sculier, Anne-Pascale Meert, Max Guillot, Marie-Pierre Ledoux, Thierry Braun, Quentin Maestraggi, Baptiste Michard, Vincent Castelain, Raoul Herbrecht, Francis Schneider, Severine Couffin, David Lobo, Nicolas Mongardon, Gilles Dhonneur, Roman Mounier, Pierrick Le Borgne, Sophie Couraud, Jean-Etienne Herbrecht, Alexandra Boivin, François Lefebvre, Pascal Bilbault, Setti-Aouicha Zelmat, Djamila-Djahida Batouche, Fatima Mazour, Belkacem Chaffi, Nadia Benatta, Ali Habiba Sik, I Talik, Maxime Perrier, Eliane Gouteix, Claude Koubi, Annabelle Escavy, Victoria Guilbaut, Jean-Philippe Fosse, Rahma Ben Jazia, Ahmed Abdelghani, Pierre-Julien Cungi, Julien Bordes, Cédric Nguyen, Candice Pierrou, Maximilien Cruc, Alain Benois, Frédéric Duprez, Thierry Bonus, Grégory Cuvelier, Sandra Ollieuz, Sharam Machayekhi, Frédéric Paciorkowski, Gregory Reychler, Remi Coudroy, Arnaud W Thille, Xavier Drouot, Véronique Diaz, Jean-Claude Meurice, René Robert, Olfa Turki, Hmida Chokri Ben, Mona Assefi, Romain Deransy, Hélène Brisson, Antoine Monsel, Filomena Conti, Olivier Scatton, Olivier Langeron, Hassen Ben Ghezala, Salah Snouda, Chiekh Imen Ben, Moez Kaddour, Anwar Armel, Lafrikh Youness, Bensaid Abdelhak, Miloudi Youssef, Al Harrar Najib, Amouzoun Mustapha, Mtioui Noufel, Zamd Mohamed, El Khayat Salma, Medkouri Ghizlane, Benghanam Mohamed, Ramdani Benyounes, Florent Montini, Sébastien Moschietto, Emilien Gregoire, Guillaume Claisse, Julien Guiot, Philippe Morimont, Jean-Marie Krzesinski, Christophe Mariat, Bernard Lambermont, Etienne Cavalier, Pierre Delanaye, Soumia Benbernou, Sofiane Ilies, Abdelkader Azza, Khalida Bouyacoub, Meriem Louail, Houria Mokhtari-Djebli, Romain Arrestier, Fabrice Daviaud, Xavier Laborne Francois, Elsa Brocas, Gérald Choukroun, Oscar Peñuelas, José-Angel Lorente, Pablo Cardinal-Fernandez, José-Maria Rodriguez, José-Antonio Aramburu, Andres Esteban, Fernando Frutos-Vivar, Laurent Bitker, Nicolas Costes, Didier Le Bars, Franck Lavenne, Mojgan Devouassoux, Jean-Christophe Richard, Malika Mechati, Marc Gainnier, Laurent Papazian, Christophe Guervilly, Aude Garnero, Jean Michel Arnal, Hadrien Roze, Jean Christophe Richard, Benjamin Repusseau, Antoine Dewitte, Olivier Joannes-Boyau, Alexandre Ouattara, Nadia Harbouze, A M Amine, A G Olandzobo, Alexandre Herbland, Marie Richard, Nicolas Girard, Lucile Lambron, Olivier Lesieur, Sarah Wainschtein, Sidonie Hubert, Albane Hugues, Marc Tran, Philippe Bouillard, Vlad Loteanu, Maxime Leloup, Alexandra Laurent, Florent Lheureux, Alessia Prestifilippo, Martin Delgado Maria Cruz, Rigal Romain, Massimo Antonelli, Torra Lluis Blanch, Franck Bonnetain, Maria Grazzia-Bocci, Jordi Mancebo, Emmanuel Samain, Hebert Paul, Gilles Capellier, Taissa Zavgorodniaia, Marion Soichot, Isabelle Malissin, Sebastian Voicu, Pierre Garçon, Antoine Goury, Lamia Kerdjana, Nicolas Deye, Emmanuel Bourgogne, Bruno Megarbane, Olfa Mejri, Marwa Ben Hmida, Salma Tannous, Lucie Chevillard, Laurence Labat, Patricia Risede, Hana Fredj, Maxime Léger, Marion Brunet, Gaël Le Roux, David Boels, Nicolas Lerolle, Souaad Farah, Hélène Amiel-Niemann, Nathalie Kubis, Xavier Declèves, Nicoals Peyraux, Frederic Baud, Micaela Serafini, Jean-Claude Alvarez, Annette Heinzelman, Mathieu Jozwiak, Sandrine Millasseau, Jean-Louis Teboul, Jean-Emmanuel Alphonsine, François Depret, Nathalie Richard, Pierre Attal, Christian Richard, Xavier Monnet, Denis Chemla, Salma Jerbi, Wafa Khedhiri, Hatem Necib, Paolo Scarfo, Charles Chevalier, Michael Piagnerelli, Alexandre Lafont, Antoine Galy, Claire Mancia, Amel Zerhouni, Kheira Tabeliouna, Ali Gaja, Bassem Hamrouni, Abir Malouch, Sami Fourati, Rihab Messaoud, Youssef Zarrouki, Amra Ziadi, Manal Rhezali, Zahira Zouizra, Drissi Boumzebra, Mohamed Abdennasser Samkaoui, Jennifer Brunet, Bertrand Canoville, Pierre Verrier, Calin Ivascau, Amélie Seguin, Xavier Valette, Damien Du Cheyron, Cedric Daubin, Wulfran Bougouin, Nadia Aissaoui, Lionel Lamhaut, Daniel Jost, Carole Maupain, Frankie Beganton, Adrien Bouglé, Florence Dumas, Eloi Marijon, Xavier Jouven, Alain Cariou, Florent Poirson, Ulriikka Chaput, Thomas Beeken, Leclerc Maxime, Oueslati Haikel, Dominique Vodovar, Jonathan Chelly, Philippe Marteau, Richard Chocron, Philippe Juvin, Thomas Loeb, Frederic Adnet, Eric Lecarpentier, Antoine Riviere, Bertand De Cagny, Thierry Soupison, Elodie Privat, Joséphine Escutnaire, Cyrielle Dumont, Valentine Baert, Christian Vilhelm, Hervé Hubert, Stéphane Leteurtre, Marion Fresco, Michael Bubenheim, Gaetan Beduneau, Dorothée Carpentier, Steven Grange, Elise Artaud-Macari, Benoit Misset, Fabienne Tamion, Christophe Girault, Guillaume Dumas, Sylvie Chevret, Virginie Lemiale, Djamel Mokart, Julien Mayaux, Frédéric Pène, Martine Nyunga, Pierre Perez, Anne-Sophie Moreau, Fabrice Bruneel, François Vincent, Kada Klouche, Jean Reignier, Antoine Rabbat, Elie Azoulay, Jean-Pierre Frat, Stéphanie Ragot, Jean-Michel Constantin, Gwenael Prat, Alain Mercat, Thierry Boulain, Alexandre Demoule, Jérôme Devaquet, Saad Nseir, Julien Charpentier, Laurent Argaud, Pascal Beuret, Jean-Damien Ricard, Christelle Teiten, Nicolas Marjanovic, Nicola Palamin, Erwan L'Her, Arthur Bailly, Julie Boisramé-Helms, Benoit Champigneulle, Toufik Kamel, Emmanuelle Mercier, Aurélie Le Thuaut, Jean-Baptiste Lascarrou, Amélie Rolle, Audrey De Jong, Gérald Chanques, Samir Jaber, Geoffroy Hariri, Jean-Luc Baudel, Vincent Dubée, Gabriel Preda, Simon Bourcier, Jeremie Joffre, Naïke Bigé, Hafid Ait-Oufella, Eric Maury, Houda Mater, Hamid Merdji, David Grimaldi, Christophe Rousseau, Jean-Paul Mira, Jean-Daniel Chiche, Ines Sedghiani, A Benabderrahim, Dhekra Hamdi, Asma Jendoubi, Mohamed Ali Cherif, Youssef Zied El Hechmi, Jerbi Zouheir, François Bagate, Radhwen Bousselmi, Frédérique Schortgen, Pierre Asfar, Emmanuel Guérot, Grelon Fabien, Nadia Anguel, Lasocki Sigismond, Henry-Lagarrigue Matthieu, Frédéric Gonzalez, Legay François, Christophe Guitton, Maleka Schenck, Doise Jean-Marc, Didier Dreyfuss, Peter Radermacher, Antoine Frère, Laurent Martin-Lefèvre, Gwenhaël Colin, Maud Fiancette, Matthieu Henry-Laguarrigue, Jean-Claude Lacherade, Christine Lebert, Isabelle Vinatier, Aihem Yehia, Aurélie Joret, Nicolas Menunier-Beillard, Dalila Benzekri-Lefevre, Arnaud Desachy, Fréderic Bellec, Gaëtan Plantefève, Jean-Pierre Quenot, Ferhat Meziani, Elsa Tavernier, Stephan Ehrmann, Nicolas Chudeau, Tommy Raveau, Valérie Moal, Pascal Houillier, Emmanuelle Rouve, Karim Lakhal, Charlotte Salmon Gandonnière, Youenn Jouan, Laetitia Bodet-Contentin, Adrien Balmier, Jonathan Messika, Etienne De Montmollin, Victorine Pouyet, Benjamin Sztrymf, Abirami Thiagarajah, Damien Roux, Marc Pineton De Chambrun, Charles-Edouard Luyt, François Beloncle, Nathalie Zapella, Stanislas Ledochowsky, Nicolas Terzi, Jean-Marc Mazou, Romain Sonneville, Sylvie Paulus, Yannick Fedun, Mickael Landais, Jean-Herlé Raphalen, Alain Combes, Zahir Amoura, Aemilia Jacquemin, Felipe Guerrero, Bertrand Marcheix, Nicolas Hernandez, Olivier Fourcade, Bernard Georges, Clément Delmas, Sarah Makoudi, Audrey Genton, Rémy Bernard, Guillaume Lebreton, Julien Amour, Charlotte Mazet, Fanny Bounes, Gurbuz Murat, Laure Cronier, Guillaume Robin, Caroline Biendel, Stein Silva, Samia Boubeche, Caroline Abriou, Véronique Wurtz, Vincent Scherrer, Nathalie Rey, Gioia Gastaldi, Benoit Veber, Fabien Doguet, Arnaud Gay, Bertrand Dureuil, Emmanuel Besnier, Antoine Rouget, Guillaume Gantois, Eric Magalhaes, Ruben Wanono, Roland Smonig, Mathilde Lermuzeaux, Jordane Lebut, Andremont Olivier, Claire Dupuis, Aguila Radjou, Bruno Mourvillier, Mathilde Neuville, Marie Pia D'ortho, Lila Bouadma, Anny Rouvel-Tallec, Marika Rudler, Nicolas Weiss, Vincent Perlbarg, Damien Galanaud, Dominique Thabut, Emna Rachdi, Ghada Mhamdi, Ahlem Trifi, Rim Abdelmalek, Sami Abdellatif, Foued Daly, Rochdi Nasri, Hanene Tiouiri, Salah Ben Lakhal, Geoffroy Rousseau, Romain Asmolov, Leslie Grammatico-Guillon, Adrien Auvet, Said Laribi, Denis Garot, Pierre François Dequin, Antoine Guillon, Jean-Louis Fergé, Gwénolé Abgrall, Ronan Hinault, Shazima Vally, Benoit Roze, Agathe Chaplain, Cyrille Chabartier, Anne-Charlotte Savidan, Sabia Marie, Andre Cabie, Dabor Resiere, Ruddy Valentino, Hossein Mehdaoui, Lucas Benarous, Marième Soda-Diop, Fouad Bouzana, Gilles Perrin, Jeremy Bourenne, Béatrice Eon, Dominique Lambert, Agnes Trebuchon, Géraldine Poncelet, Fleur Le Bourgeois, Levy Michael, Guillot Camille, Jérôme Naudin, Anna Deho, Stéphane Dauger, Michaël Sauthier, Krystale Bergeron-Gallant, Guillaume Emeriaud, Philippe Jouvet, Nicolas Tiebergien, Matthias Jacquet-Lagrèze, Jean-Luc Fellahi, Florent Baudin, Sandrine Essouri, Etienne Javouhey, Claude Guérin, Marie Lampin, Ouardia Mamouri, Patrick Devos, Yasemin Karaca-Altintas, Matthieu Vinchon, David Brossier, Redha Eltaani, Sonia Teyssedre, Meyet Sabine, Jean-Christophe Bouchut, Olivier Peguet, Lucie Petitdemange, Anne Sophie Guilbert, Nabil Tabet Aoul, Zakaria Addou, Nabil Aouffen, Benqqa Anas, Samira Kalouch, Khalid Yaqini, Aziz Chlilek, Rchi Abdou, Perrine Gravellier, Julie Chantreuil, Nadine Travers, Antoine Listrat, Claire Le Reun, Geraldine Favrais, Zoe Coppere, Stéphane Blanot, Juliette Montmayeur, Régis Bronchard, Stephane Rolando, Gilles Orliaguet, Pierre-Louis Leger, Jérôme Rambaud, Emilie Thueux, Alexandra De Larrard, Véronique Berthelot, Julien Denot, Marie Reymond, Alain Amblard, Sarah Morin-Zorman, Etienne Lengliné, Claire Pichereau, Eric Mariotte, Canet Emmanuel, Julien Poujade, Guillaume Trumpff, Ralf Janssen-Langenstein, Marie-Line Harlay, Noorah Zaid, Nawel Ait-Ammar, Christine Bonnal, Jean-Claude Merle, Francoise Botterel, Eric Levesque, Zakaria Riad, Mehdi Mezidi, Hodane Yonis, Mylène Aublanc, Sophie Perinel-Ragey, Floriane Lissonde, Aurore Louf-Durier, Romain Tapponnier, Bruno Louis, Jean-Marie Forel, Magali Bisbal, Samuel Lehingue, Romain Rambaud, Mélanie Adda, Sami Hraiech, Elisa Marchi, Antoine Roch, Vincent Guerin, Sacha Rozencwajg, Matthieu Schmidt, Guillaume Hekimian, Nicolas Bréchot, Jean Louis Trouillet, Sébastien Besset, Guillaume Franchineau, Ania Nieszkowska, Leprince Pascal, Maud Loiselle, Chemam Sarah, Dangers Laurence, Thomas Guillemette, Alice Jacquens, Sebastien Kerever, Bertrand Guidet, Philippe Aegerter, Vincent Das, Muriel Fartoukh, Jan Hayon, Mathieu Desmard, Jean-Pierre Fulgencio, Benjamin Zuber, A Soufi, K Khaleq, D Hamoudi, Charlotte Garret, Matthieu Peron, Emmanuel Coron, Cédric Bretonnière, Etienne Audureau, Winters Audrey, Duvoux Christophe, Jacquelinet Christian, Azoulay Daniel, Feray Cyrille, Wissal Aissaoui, Kawtar Rghioui, Wafae Haddad, Houcine Barrou, Anna Carteaux-Taeib, Renato Lupinacci, Gilles Manceau, Florence Jeune, Christophe Tresallet, Sahar Habacha, Ines Fathallah, Aymen Zoubli, Rafaa Aloui, Nadia Kouraichi, Emilie Jouet, Julie Badin, Brice Fermier, Marc Feller, Mathieu Serie, Jérôme Pillot, William Marie, Chloé Gisbert-Mora, Camille Vinclair, Pierre Lesbordes, Pascal Mathieu, Fabienne De Brabant, Emmanuel Muller, Marie-Aline Robaux, Mikhael Giabicani, Antoine Marchalot, Stéphanie Gelinotte, Pierre Louis Declercq, Jean-Pierre Eraldi, François Bougerol, Nicolas Meunier-Beillard, Hervé Devilliers, Jean-Philippe Rigaud, Camille Verrière, Fanny Ardisson, Nancy Kentish-Barnes, Gwenaëlle Jacq, Akli Chermak, Alexandre Lautrette, Matthieu Legrand, Alexis Soummer, Guillaume Thiery, Alice Cottereau, Emmanuel Canet, Marie Caujolle, Jérôme Allyn, Dorothée Valance, Caroline Brulliard, Olivier Martinet, Julien Jabot, Thomas Gallas, David Vandroux, Nicolas Allou, Arthur Durand, Rémi Nevière, Florian Delguste, Eric Boulanger, Sebastien Preau, Ruste Martin, Hélène Cochet, Jean Pierre Ponthus, Virginie Amilien, Martial Tchir, Elise Barsam, Mohsen Ayoub, Jean Francois Georger, Izaute Guillame, Julie Assaraf, Simona Tripon, Maxime Mallet, Guilaume Barbara, Guillaume Louis, Stéphane Gaudry, Nicolas Barbarot, Angéline Jamet, Hervé Outin, Sébastien Gibot, Pierre-Edouard Bollaert, Mathilde Holleville, Stéphane Legriel, Anne Laure Chateauneuf, Sébastien Cavelot, Jean-Denis Moyer, Jean Pierre Bedos, Philippe Merle, Aurelie Laine, De Sa Natalie, Mathieu Cornuault, Jérome Libot, Karim Asehnoune, Bertrand Rozec, Jacques Dantal, Michel Videcoq, Thècle Degroote, Emmanuelle Jaillette, Farid Zerimech, Balduyck Malika, Jean-François Llitjos, Marlène Amara, Guillaume Lacave, Béatrice Pangon, José Mavinga, Joseph Nsiala Makunza, M E Mafuta, Yves Yanga, Amisi Eric, Jp Ilunga, Ma Kilembe, Fanny Alby-Laurent, Julie Toubiana, Amel Mokline, Achraf Laajili, Helmi Amri, Imene Rahmani, Nidhal Mensi, Lazheri Gharsallah, Sofiene Tlaili, Bahija Gasri, Rym Hammouda, Amen Allah Messadi, Pierre-Antoine Allain, Nathallie Gault, Catherine Paugam-Burtz, Arnaud Foucrier, Bassem Chatbri, Yousra Bourbiaa, Lamia Thabet, Arthur Neuschwander, Looten Vincent, Jennifer Beck, Chhor Vibol, Yavchitz Amelie, Matthieu Resche-Rigon, Jean MantzRomain Pirracchio, Côme Bureau, Maxens Decavèle, Sébastien Campion, Roukia Ainsouya, Marie-Cécile Niérat, Hélène Prodanovic, Mathieu Raux, Thomas Similowski, Bruno-Pierre Dubé, Suela Demiri, Martin Dres, Faten May, Hervé Quintard, Ilias Kounis, Faouzi Saliba, Stephane André, Marc Boudon, Philippe Ichai, Aline Younes, Lionel Nakad, Audrey Coilly, Teresa Antonini, Rodolphe Sobesky, Eleonora De Martin, Didier Samuel, Noemie Hubert, Mai-Anh Nay, Johann Auchabie, Bruno Giraudeau, Reignier Jean, Michaël Darmon, Stephane Ruckly, Maïté Garrouste-Orgeas, Elisabeth Gratia, Dany Goldgran-Toledano, Samir Jamali, Anne Sylvie Dumenil, Carole Schwebel, Laurent Brisard, Philippe Bizouarn, Thierry Lepoivre, Johanna Nicolet, Jean Christophe Rigal, Jean Christian Roussel, Cherifa Cheurfa, Julien Abily, Thomas Lescot, Isaline Page, Stéphanie Warnier, Monique Nys, Anne-Françoise Rousseau, Pierre Damas, Fabrice Uhel, Mathieu Lesouhaitier, Murielle Grégoire, Baptiste Gaudriot, Arnaud Gacouin, Yves Le Tulzo, Erwan Flecher, Karin Tarte, Jean-Marc Tadié, Quentin Georges, M Soares, Kyeongman Jeon, Sandra Oeyen, Chin Kook Rhee, Pascale Gruber, Marlies Ostermann, Quentin Hill, Peter Depuydt, Christelle Ferra, Alice Muller, Bourmaud Aurelie, Christopher Niles, Fabien Herbert, Sylviane Pied, Séverine Loridant, Nadine François, Anne Bignon, Boualem Sendid, Caroline Lemaitre, Celine Dupre, Aymen Zayene, Lucie Portier, Nathalie De Freitas Caires, Philippe Lassalle, Aymeric Le Neindre, Pascal Selot, Daniel Ferreiro, Maria Bonarek, Stépahen Henriot, Julie Rodriguez, Mara Taddei, Mauro Di Bari, Cheryl Hickmann, Diego Castanares-Zapatero, Louise Deldicque, Peter Van Den Bergh, Gilles Caty, Jean Roeseler, Marc Francaux, Pierre-François Laterre, Bastien Dupuis, Sharam Machayeckhi, Celine Sarfati, Alex Moore, Paula Mendialdua, Emilie Rodet, Catherine Pilorge, Francois Stephan, Saida Rezaiguia-Delclaux, Jonathan Dugernier, Michel Hesse, Thibaud Jumetz, Emilie Bialais, Virginie Depoortere, Jean Bernard Michotte, Xavier Wittebole, François Jamar
No abstract text is available yet for this article.
January 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28074401/adipsic-diabetes-insipidus-in-adult-patients
#17
REVIEW
Martín Cuesta, Mark J Hannon, Christopher J Thompson
INTRODUCTION: Adipsic diabetes insipidus (ADI) is a very rare disorder, characterized by hypotonic polyuria due to arginine vasopressin (AVP) deficiency and failure to generate the sensation of thirst in response to hypernatraemia. As the sensation of thirst is the key homeostatic mechanism that prevents hypernatraemic dehydration in patients with untreated diabetes insipidus (DI), adipsia leads to failure to respond to aquaresis with appropriate fluid intake. This predisposes to the development of significant hypernatraemia, which is the typical biochemical manifestation of adipsic DI...
January 10, 2017: Pituitary
https://www.readbyqxmd.com/read/28073931/histones-and-neutrophil-extracellular-traps-enhance-tubular-necrosis-and-remote-organ-injury-in-ischemic-aki
#18
Daigo Nakazawa, Santhosh V Kumar, Julian Marschner, Jyaysi Desai, Alexander Holderied, Lukas Rath, Franziska Kraft, Yutian Lei, Yuichiro Fukasawa, Gilbert W Moeckel, Maria Lucia Angelotti, Helen Liapis, Hans-Joachim Anders
Severe AKI is often associated with multiorgan dysfunction, but the mechanisms of this remote tissue injury are unknown. We hypothesized that renal necroinflammation releases cytotoxic molecules that may cause remote organ damage. In hypoxia-induced tubular epithelial cell necrosis in vitro, histone secretion from ischemic tubular cells primed neutrophils to form neutrophil extracellular traps. These traps induced tubular epithelial cell death and stimulated neutrophil extracellular trap formation in fresh neutrophils...
January 10, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28073789/dynamics-of-convulsive-seizure-termination-and-postictal-generalized-eeg-suppression
#19
Prisca R Bauer, Roland D Thijs, Robert J Lamberts, Demetrios N Velis, Gerhard H Visser, Else A Tolner, Josemir W Sander, Fernando H Lopes da Silva, Stiliyan N Kalitzin
It is not fully understood how seizures terminate and why some seizures are followed by a period of complete brain activity suppression, postictal generalized EEG suppression. This is clinically relevant as there is a potential association between postictal generalized EEG suppression, cardiorespiratory arrest and sudden death following a seizure. We combined human encephalographic seizure data with data of a computational model of seizures to elucidate the neuronal network dynamics underlying seizure termination and the postictal generalized EEG suppression state...
January 10, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28073578/prophylactic-cranial-irradiation-after-definitive-chemoradiotherapy-for-limited-stage-small-cell-lung-cancer-do-all-patients-benefit
#20
Ahsan S Farooqi, Emma B Holliday, Pamela K Allen, Xiong Wei, James D Cox, Ritsuko Komaki
PURPOSE: Prophylactic cranial irradiation (PCI) can improve overall survival (OS) and suppress brain metastases (BM) in patients with limited-stage small cell lung cancer (LS-SCLC) after complete response to primary therapy. However, PCI can be toxic. We sought to identify characteristics of patients who may not benefit from PCI. METHODS: We identified 658 patients who received chemoradiotherapy at MD Anderson in 1986-2012; 364 received PCI and 294 did not. Median follow-up time was 21...
January 7, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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