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Cardiovascular disease glycemic index

Bedowra Zabeen, Ana Margarida Balsa, Nasreen Islam, Mukta Parveen, Jebun Nahar, Kishwar Azad
Introduction: Dyslipidemia and hyperglycemia are metabolic abnormalities commonly found in young patients with Type 1 diabetes mellitus (T1DM) and both increase the risk of cardiovascular disease. Methods: This cross-sectional study was aimed to evaluate the pattern of dyslipidemia and its relationship with other risk factors in children and adolescents with T1DM. A total of 576 T1DM patients aged 10-18 years who attended Changing Diabetes in Children, a pediatric diabetes clinic in Bangladesh Institute of Research and Rehabilitation for Diabetes, Endocrine and Metabolic Disorders over 1 year period from July 2015 to June 2016 were included in this study...
January 2018: Indian Journal of Endocrinology and Metabolism
Vajihe Izadi, Fahimeh Haghighatdoost, Parisa Moosavian, Leila Azadbakht
BACKGROUND: There are no investigations regarding the effects of consuming low-energy-dense diets rich in multiple functional foods on weight-loss maintenance, inflammatory markers, and cardiovascular disease (CVD) risk factors simultaneously. METHOD: This randomized controlled trial design was conducted on 90 men and women who were under a previous weight loss diet. Three months of intervention with recruitment at Allzahra Hospital, Isfahan, Iran, was done. Intervention was conducted following achieving 7-11 kg weight loss...
March 12, 2018: Journal of the American College of Nutrition
Francisco Jesús Represas Carrera, Álvaro Carrera García, Ana Clavería Fontán
OBJECTIVE: Type 2 Diabetes Mellitus is a chronic disease that represent an important problem of public health. The objective of this study was to describe the sociodemographic, anthropometric, metabolic control, comorbidity and cardiovascular risk characteristics of patients diagnosed with Diabetes Mellitus type 2 in the health area of Vigo. METHODS: Retrospective observational descriptive study. Between March and September 2016, it did telephone interview and an audit of electronic medical records to 195 patients ≥ 18 years old from the health area of Vigo diagnosed with type 2 Diabetes Mellitus...
March 9, 2018: Revista Española de Salud Pública
Carmen Lambert, Judit Cubedo, Teresa Padró, Gemma Vilahur, Sergi López-Bernal, Milagros Rocha, Antonio Hernández-Mijares, Lina Badimon
BACKGROUND: Patients with type 2 diabetes mellitus (T2DM) have a higher incidence of cardiovascular (CV) events. The ingestion of high-glycemic index (GI) diets, specially sweetened beverage consumption, has been associated with the development of T2DM and CV disease. OBJECTIVE: We investigated the effects of the intake of a sweetened beverage, obtained from natural carbohydrates containing pinitol (PEB) compared to a sucrose-enriched beverage (SEB) in the context of impaired glucose tolerance (IGT) and diabetes...
February 27, 2018: Nutrients
Corinna Storz, Susanne Rospleszcz, Roberto Lorbeer, Holger Hetterich, Sigrid D Auweter, Wieland Sommer, Jürgen Machann, Sergios Gatidis, Wolfgang Rathmann, Margit Heier, Birgit Linkohr, Christa Meisinger, Maximilian Reiser, Udo Hoffmann, Annette Peters, Christopher L Schlett, Fabian Bamberg
INTRODUCTION: Detailed mechanisms in the pathophysiology of diabetes disease are poorly understood, but structural alterations in various organ systems incur an elevated risk for cardiovascular events and adverse outcome. The aim of this study was to compare multiorgan subclinical disease phenotypes by magnetic resonance (MR) imaging to study differences between subjects with prediabetes, diabetes, and normal controls. MATERIALS AND METHODS: Subjects without prior cardiovascular disease were enrolled in a prospective case-control study and underwent multiorgan MR for the assessment of metabolic and arteriosclerotic alterations, including age-related white matter changes, hepatic proton density fat fraction, visceral adipose tissue volume, left ventricular remodeling index, carotid plaque, and late gadolinium enhancement...
February 28, 2018: Investigative Radiology
Peiwen Zhang, Chen Yang, Honghui Guo, Jiaji Wang, Shengqiang Lin, Huamei Li, Yan Yang, Wenhua Ling
BACKGROUND: The use of coenzyme Q10 (CoQ10) as an adjuvant treatment with routine clinical therapy against metabolic diseases has shown benefit. However, the effect of CoQ10 as a primary preventive agent against cardiovascular diseases (CVDs) has not been well studied. OBJECTIVE: The objective of this study was to investigate the effect of CoQ10 on CVD risk factors in dyslipidemic patients. METHODS: In this randomized, double-blinded, placebo-controlled trial, 101 dyslipidemic subjects without taking any hypoglycemic or hypolipidemic drugs were administrated to 120 mg CoQ10 or placebo daily for 24 weeks...
December 21, 2017: Journal of Clinical Lipidology
Taku Koyama, Atsushi Tanaka, Hisako Yoshida, Jun-Ichi Oyama, Shigeru Toyoda, Masashi Sakuma, Teruo Inoue, Yoritaka Otsuka, Koichi Node
Endothelial dysfunction contributes to poor cardiovascular prognosis in patients with type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD). The effect of dipeptidyl peptidase-4 inhibitors on endothelial function remains controversial. We sought to compare the effects of linagliptin and voglibose on endothelial function, as assessed by reactive hyperemia-peripheral arterial tonometry (RH-PAT). Sixteen patients with newly diagnosed T2DM and CAD were randomized 1:1 to linagliptin (5 mg, once-daily) or voglibose (0...
February 9, 2018: Heart and Vessels
Corinna Storz, Sophia D Heber, Susanne Rospleszcz, Jürgen Machann, Sabine Sellner, Konstantin Nikolaou, Roberto Lorbeer, Sergios Gatidis, Stefanie Elser, Annette Peters, Christopher L Schlett, Fabian Bamberg
OBJECTIVE: To study the relationship of area- and volumetric-based visceral and subcutaneous adipose tissue (VAT and SAT) by magnetic resonance imaging (MRI) and their ratio in subjects with impaired glucose metabolism from the general population. METHODS: Subjects from a population-based cohort with established prediabetes, diabetes and healthy controls without prior cardiovascular diseases underwent 3 Tesla MRI. VAT and SAT were assessed as total volume and area on a single slice, and their ratio (VAT/SAT) was calculated...
February 1, 2018: British Journal of Radiology
Viswanathan Mohan, Rajagopal Gayathri, Lindsay M Jaacks, Nagarajan Lakshmipriya, Ranjit Mohan Anjana, Donna Spiegelman, Raman Ganesh Jeevan, Kandappa K Balasubramaniam, Shanmugam Shobana, Mathialagan Jayanthan, Viswanathan Gopinath, Selvakumar Divya, Vasudevan Kavitha, Parthasarathy Vijayalakshmi, Mookambika Ramya Bai R, Ranjit Unnikrishnan, Vasudevan Sudha, Kamala Krishnaswamy, Jordi Salas-Salvadó, Walter C Willett
Background: There is increasing evidence that nut consumption decreases the risk of cardiovascular disease. However, there are few data on the health effects of cashew nuts among adults with type 2 diabetes (T2DM). Objective: The study aimed to investigate the effects of cashew nut supplementation on glycemia, body weight, blood pressure, and lipid profile in Asian Indians with T2DM. Methods: In a parallel-arm, randomized controlled trial, 300 adults with T2DM [mean ± SD age: 51 ± 9...
January 1, 2018: Journal of Nutrition
Chelsea Anderson, Ginger L Milne, Yong-Moon Mark Park, Dale P Sandler, Hazel B Nichols
Background: Diets with a high glycemic index (GI) and glycemic load (GL) have been hypothesized to increase oxidative stress, but the limited human studies are inconsistent. Objective: The aim of this cross-sectional study was to investigate associations between dietary GI, GL, and carbohydrate intake and oxidative stress, as measured by F2-isoprostanes (F2-IsoPs). Methods: Concentrations of F2-IsoP and its metabolite (15-F2t-IsoP-M) were measured in urine samples collected at enrollment from 866 premenopausal women (aged 35-54 y) participating in the Sister Study...
January 1, 2018: Journal of Nutrition
Armin Mahdiani, Masoume Kheirandish, Shokoufeh Bonakdaran
BACKGROUND: The role of chronic inflammation in insulin resistance states and the pathogenesis of metabolic syndrome, cardiovascular disease and diabetes have been reported earlier. White blood cell (WBC) count is an easy marker for estimation of systemic inflammation. OBJECTIVE: This study is to clarify whether WBC count associate with insulin resistance in type 2 diabetic patients. METHOD: This cross sectional study was conducted in 283 patients with type 2 diabetes and in 283 healthy non diabetic subjects as control group...
January 19, 2018: Current Diabetes Reviews
Tomoaki Inoue, Noriyuki Sonoda, Shinsuke Hiramatsu, Shinichiro Kimura, Yoshihiro Ogawa, Toyoshi Inoguchi
INTRODUCTION: Previous studies have shown that serum bilirubin concentration is inversely associated with the risk of cardiovascular disease. The relationship between serum bilirubin concentration and left ventricular geometry, however, has not been investigated in patients with diabetes mellitus. METHODS: In this cohort study, 158 asymptomatic patients with type 2 diabetes mellitus without overt heart disease were enrolled. Left ventricular structure and function were assessed using echocardiography...
January 15, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
Katerina K Naka, Katerina Papathanassiou, Aris Bechlioulis, Konstantinos Pappas, Stelios Tigas, Dimitrios Makriyiannis, Sophia Antoniou, Nikolaos Kazakos, Alexandra Margeli, Ioannis Papassotiriou, Agathocles Tsatsoulis, Lampros K Michalis
BACKGROUND: The pathophysiology of atherosclerosis in type 2 diabetes mellitus (T2DM) is multifactorial. The association of vascular indices with circulating biomarkers of inflammation and insulin resistance and their role in the long-term cardiovascular prognosis in T2DM patients were currently investigated. PATIENTS AND METHODS: Patients with T2DM and poor glycemic control without known cardiovascular diseases (n=119) at baseline were enrolled and followed for about 9years...
December 27, 2017: Clinical Biochemistry
Sanjay Basu, Sridharan Raghavan, Deborah J Wexler, Seth A Berkowitz
OBJECTIVE: Identifying patients who may experience decreased or increased mortality risk from intensive glycemic therapy for type 2 diabetes remains an important clinical challenge. We sought to identify characteristics of patients at high cardiovascular risk with decreased or increased mortality risk from glycemic therapy for type 2 diabetes using new methods to identify complex combinations of treatment effect modifiers. RESEARCH DESIGN AND METHODS: The machine learning method of gradient forest analysis was applied to understand the variation in all-cause mortality within the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial ( N = 10,251), whose participants were 40-79 years old with type 2 diabetes, hemoglobin A1c (HbA1c ) ≥7...
March 2018: Diabetes Care
Gloria K W Leung, Catherine E Huggins, Maxine P Bonham
BACKGROUND & AIMS: Glucose metabolism is, in part, regulated by the circadian rhythm. Postprandial glucose response is exaggerated and insulin sensitivity is reduced at night compared with the morning. Sustained poor glucose tolerance may be related to the increased risk of type-2 diabetes mellitus and cardiovascular disease experienced by shift workers. Manipulation of meal type may be able to dampen such postprandial excursions. Therefore, the study's aim was to investigate postprandial glucose and insulin responses to a low glycemic index (GI) meal in the morning compared to night in healthy volunteers...
November 22, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Alessandra S M Matheus, Maria de Fátima B da Matta, Eliete Leão S Clemente, Maria de Lourdes G Rodrigues, Débora Cristina T Valença, Marília B Gomes
OBJECTIVES: To find out an normality value for microvascular response (physiological and pharmacological) assessed through laser speckle contrast imaging (LSCI) based on Endo-PAT, which identifies the ones with Endothelial Dysfunction (ED) in patients with Type 1 Diabetes (T1D). METHODS: Patients with T1D, aged ≥12years underwent a clinical-epidemiological questionnaire. Fasting blood samples were obtained (lipid profile, glycemic control and levels of C-reactive protein)...
December 2, 2017: Microvascular Research
Angela D Liese, Xiaonan Ma, Xiaoguang Ma, Murray A Mittleman, Natalie S The, Debra A Standiford, Jean M Lawrence, Catherine Pihoker, Santica M Marcovina, Elizabeth J Mayer-Davis, Robin C Puett
BACKGROUND: Systemic inflammation is a key process underlying cardiovascular disease (CVD) development, and CVD risk is significantly elevated in persons with type 1 diabetes (T1D). Youth with T1D exhibit increased levels of inflammation. Studies in persons without diabetes suggest that dietary quality influences inflammation, yet little is known about dietary influences on inflammation in youth with T1D. METHODS: This study evaluated the association of four distinct dietary quality indices (Dietary Approaches to Stop Hypertension (DASH), Healthy Eating Index 2010 (HEI2010), modified KIDMED and Total Antioxidant Capacity (TAC)) with biomarkers of inflammation (C-reactive protein (CRP), fibrinogen and interleukin-6 (IL-6)) in a sample of 2520 youth with T1D participating in the SEARCH for Diabetes in Youth Study...
February 2018: Journal of Diabetes and its Complications
Ying Liu, Xia Jiang, Xin Chen
BACKGROUND: This study is to compare the effects of Liraglutide and Metformin alone or combined treatment on the cardiac function in T2DM patients complicated with CAD. METHODS: 120 T2DM patients were included at Endocrinology Department of Tianjin First Center Hospital (Tianjin, China) from April 2012 to September 2013. The study contained two sections. Section 1: 30 patients in group 1 was treated with Liraglutide (Novo Nordisk) (1.2 mg/d), and 30 patients in group 2 with Metformin (Shiguibao) (1500 mg/d) for 24 weeks...
December 2, 2017: Lipids in Health and Disease
Jeannie Tay, Campbell H Thompson, Natalie D Luscombe-Marsh, Thomas P Wycherley, Manny Noakes, Jonathan D Buckley, Gary A Wittert, William S Yancy, Grant D Brinkworth
AIM: To examine whether a low-carbohydrate, high-unsaturated/low-saturated fat diet (LC) improves glycaemic control and cardiovascular disease (CVD) risk factors in overweight and obese patients with type 2 diabetes (T2D). METHODS: A total of 115 adults with T2D (mean [SD]; BMI, 34.6 [4.3] kg/m2 ; age, 58 [7] years; HbA1c, 7.3 [1.1]%) were randomized to 1 of 2 planned energy-matched, hypocaloric diets combined with aerobic/resistance exercise (1 hour, 3 days/week) for 2 years: LC: 14% energy as carbohydrate, 28% as protein, 58% as fat (<10% saturated fat); or low-fat, high-carbohydrate, low-glycaemic index diet (HC): 53% as CHO, 17% as protein, 30% as fat (<10% saturated fat)...
November 27, 2017: Diabetes, Obesity & Metabolism
Alessandro Ciresi, Enrica Vigneri, Stefano Radellini, Felicia Pantò, Carla Giordano
INTRODUCTION: Although liraglutide is widely recognized to have glycemic and extra-glycemic effects, few studies have compared these effects in relation to hypoglycemic treatment starting from the diagnosis of diabetes. We evaluated the effectiveness of liraglutide in reducing the Framingham risk score (FRS) and visceral adiposity index (VAI) in relation to first-line hypoglycemic treatment from diagnosis of type 2 diabetes, continued without any changes. METHODS: We selected 105 diabetic outpatients who were treated with liraglutide for at least 48 months as an add-on therapy to metformin alone (group A, n = 52) or insulin secretagogues (group B, n = 53) from diagnosis time...
November 14, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
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