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Glycemic index

Sangeetha Suresh, Bijayraj Rajanbabu, Vimal Mavila Veetil, Abeed Hussain, Jaseena Nadu Veetil
Introduction: Nonalcoholic fatty liver disease (NAFLD) is a hepatic disorder that develops in the absence of alcohol intake. Obesity and diabetes are considered risk factors for the development of fatty liver; however, whether fatty liver is the cause or consequence of these conditions is not yet clear. Insulin resistance (IR) is found to be a common risk factor for the development of diabetes, obesity and fatty liver. Aims and Objectives: The aim and objective of this study is to determine the prevalence of undetected diabetes, dyslipidemia, and IR in subjects with NAFLD...
January 2018: Journal of Family Medicine and Primary Care
Yazdan Ghandi, Danial Habibi, Khadijeh Nasri, Saeed Alinejad, Hassan Taherahmad, Ali Arjmand Shabestari, Ali Nematinejad
BACKGROUND: There are some evidences supporting the relation between gestational diabetes mellitus (GDM) and diastolic dysfunction. The aim of our study was to investigate the effect of well-controlled GDM on morphological and functional myocardium. MATERIALS AND METHODS: We designed a prospective cross-sectional study to evaluate left ventricular (LV) diastolic function of 60 neonates born from mothers with well-controlled GDM (case group) on days of 3-5 after birth...
June 17, 2018: Journal of Maternal-fetal & Neonatal Medicine
Debmalya Sanyal, Sudip Chatterjee
Introduction: It is generally accepted that renal and eye changes in diabetes are concordant. There are however a fair number of patients with diabetes who have end-stage renal disease (ESRD) without any of the typical eye changes. The present study highlights the discordance between retinopathy and nephropathy and describes a series of patients of long-standing diabetes undergoing renal transplant who had little or no evidence of retinopathy. Methods: All patients with ESRD undergoing renal transplants underwent comprehensive fundus evaluation including dilated indirect ophthalmoscopy, slit lamp biomicroscopy, and fundus photography...
March 2018: Indian Journal of Endocrinology and Metabolism
Eiji Kutoh, Asuka Wada, Teruma Murayama, Jyunka Hayashi
Objectives: The aim of this project is to compare the effect of canagliflozin monotherapy on metabolic parameters between responders and nonresponders with this drug. This study is a prospective, unblinded, observational study. Subjects and Methods: Drug-naïve patients with type 2 diabetes mellitus received only 50-100 mg/day canagliflozin for 3 months ( n = 39). They were divided into two groups according to the novel "A1c index" to assess glycemic efficacies; responders ( n = 24) and nonresponders ( n = 15)...
March 2018: Indian Journal of Endocrinology and Metabolism
Maja Cigrovski Maja Cigrovski Berkovic, Ines Bilic-Curcic, Marina Gradiser, Davorka Herman-Mahecic, Vjekoslav Cigrovski, Marul Ivandic
BACKGROUND: We studied the association between leisure time physical activity (LTPA) and glycemic control, body mass index (BMI), and hypoglycemic incidents in type 1 (T1DM) and type 2 diabetes patients (T2DM). METHODS: This is a cross-sectional study of 198 diabetic patients (60 with type 1 diabetes, 138 with type 2 diabetes). LTPA was assessed by a validated 12-month questionnaire. Patients were grouped as sedentary and moderately to vigorously active. Outcome measures were Hemoglobin A1c (HbA1c), BMI, and hypoglycemic episodes...
August 7, 2017: Sports
Yuli Hu, Xiaohong Wen, Feifei Wang, Dongliang Yang, Shanshan Liu, Pan Li, Juling Xu
Introduction Hypoglycaemia is a clinical syndrome from various causes, which happens when the blood glucose concentration is too low. Many studies show that telemedicine intervention can improve glycemic control and has a positive impact on the management of diabetic patients. The purpose of this study was to evaluate the effect of telemedicine intervention on hypoglycemic event occurrences and results on hemoglobin A1c (HbA1c) and body mass index (BMI). Methods We searched the Cochrane Library, PubMed, Web of Science, the EBSCO host, and OVID to identify relevant studies published from January 2006 to December 2017...
January 1, 2018: Journal of Telemedicine and Telecare
Soraiya Ebrahimpour-Koujan, Bahram Pourghassem Gargari, Majid Mobasseri, Hadi Valizadeh, Mohammad Asghari-Jafarabadi
OBJECTIVE: This randomized clinical trial was conducted to evaluate the effects of silymarin supplementation on glycemic indices and serum lipid profile in type 2 diabetes mellitus (T2DM) patients. METHODS: 40 T2DM patients (twenty male and twenty female), 25-50 years of age and on stable medication, were recruited for the present paralleled, randomized, triple-blinded, placebo-controlled clinical trial. The participants were randomly assigned to the silymarin or placebo groups, in which the patients either received 140 mg of silymarin, thrice daily (n = 20) or placebo (n = 20) for 45 days...
May 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Amanda Liu, Margaret Marcon, Esther Assor, Farid H Mahmud, Justine Turner, Diana Mager
The study purpose was to describe dietary intake and the factors influencing micronutrient supplements (MS) use in Celiac Disease (CD) ± Type 1 Diabetes (T1D). Three-day food records collected from parents of youth (3-18 years) with CD (n = 14) ± T1D (n = 10) were assessed for macro and micronutrient intake, diet quality (DQ), glycemic index (GI), glycemic load (GL), and food group intake. Focus group methodology and thematic concept analysis were conducted to determine factors influencing adolescent MS use...
June 12, 2018: Canadian Journal of Dietetic Practice and Research
Jinkai Zhao, Yuyang Zhang, Yanwen Wu, Lingling Liu, Jie Ouyang
Naturally air-dried chestnut is a type of traditionally processed chestnut in North China which has a pleasant flavor. After air drying at room temperature and low-air humidity for two wk, the moisture, total starch content and starch relative crystallinity decreased, while the content of water-soluble sugar and amylose increased because of the dehydration and the hydrolysis of endogenous amylase. The Fourier transform infrared (FTIR) spectroscopy ratio of 1047/1022 cm-1 and the relative area of the Raman spectrum peak at 480/865 cm-1 of air-dried chestnut starch decreased in the first two wk and then increased, while the full width at half-maximum height (FWHH) of the Raman spectrum peak at 480 cm-1 showed the opposite tendency...
June 8, 2018: International Journal of Biological Macromolecules
Giti Kalantarian, Nasrin Ziamajidi, Reza Mahjoub, Mohammad Taghi Goodarzi, Massoud Saidijam, Sara Soleimani Asl, Roghayeh Abbasalipourkabir
BACKGROUND: Subcutaneous injection of insulin can lead to problems such as hypoglycemia and edema. OBJECTIVE: The purpose of this research was to evaluate the effect of oral insulin-coated trimethyl chitosan nanoparticles on control of glycemic status, IGF-1 and IGF-2 levels, and apoptosis in the hippocampus of rats with diabetes mellitus. METHODS: Insulin-coated trimethyl chitosan nanoparticles were prepared by the complex polyelectrolyte (PEC) method...
June 6, 2018: Restorative Neurology and Neuroscience
Nabila A Abdella, Olusegun A Mojiminiyi
Introduction: Studies have shown increased urine excretion of vitamin D-binding protein (VDBP) in patients with diabetic nephropathy (DN) resulting from postulated mechanisms linked to renal tubular damage. In this study, we evaluate the utility of VDBP clearance ratio as a novel determinant of glycemic status, DN, and other diabetes-associated complications. Methods: Levels of vitamin D, HbA1c, serum, urine concentrations of VDBP, and creatinine were measured in 309 subjects...
2018: Journal of Diabetes Research
Ki-Bum Won, Donghee Han, Ji Hyun Lee, Sang-Eun Lee, Ji Min Sung, Su-Yeon Choi, Eun Ju Chun, Sung Hak Park, Hae-Won Han, Jidong Sung, Hae Ok Jung, Hyuk-Jae Chang
BACKGROUND: Data on the impact of optimal glycemic control (OGC) on the progression of coronary artery calcification, an important marker for future adverse cardiovascular events in individuals with diabetes are limited. METHODS: We investigated 1637 asymptomatic adults with diabetes (56 ± 8 years, 88.8% men) and no history of coronary artery disease or stroke, who underwent serial coronary artery calcium (CAC) screening. The median inter-scan period was 3...
September 1, 2018: International Journal of Cardiology
Amir Aviram, Biana Shtaif, Galia Gat-Yablonski, Yariv Yogev
OBJECTIVE: To evaluate the relationship between adipocytokines and glycemic control. STUDY DESIGN: Prospective observational trial of gestations with gestational diabetes mellitus (GDM). Fasting glucose (FG), insulin, adiponectin, Leptin, chemerin, Retinol Binding Protein 4 (RBP-4), osteocalcin and resistin were measured. HomeOstasis model assessment of insulin resistance (HOMA-IR) and QUantitative insulin sensitivity ChecK Index (QUICKI) were calculated. Women who required medications for glycemic control were compared to women using nutritional therapy only...
June 10, 2018: Journal of Maternal-fetal & Neonatal Medicine
Ji Hye Huh, Minyoung Lee, So Young Park, Jae Hyeon Kim, Byung Wan Lee
BACKGROUND: The aim of this study was to investigate which glycemic parameters better reflect urinary N-acetyl-β-D-glucosaminidase (uNAG) abnormality, a marker for renal tubulopathy, in subjects with type 2 diabetes mellitus (T2DM) subjects with normoalbuminuria and a normal estimated glomerular filtration rate (eGFR). METHODS: We classified 1,061 participants with T2DM into two groups according to uNAG level-normal vs. high (>5.8 U/g creatinine)-and measured their biochemical parameters...
May 2, 2018: Diabetes & Metabolism Journal
Li-Li Wang, Qi Wang, Yong Hong, Omorogieva Ojo, Qing Jiang, Yun-Ying Hou, Yu-Hua Huang, Xiao-Hua Wang
OBJECTIVE: In China, a low-fat diet (LFD) is mainly recommended to help improve blood glucose levels in patients with type 2 diabetes mellitus (T2DM). However, a low-carbohydrate diet (LCD) has been shown to be effective in improving blood glucose levels in America and England. A few studies, primarily randomized controlled trials, have been reported in China as well. METHOD: Firstly, we designed two 'six-point formula' methods, which met the requirements of LCD and LFD, respectively...
May 23, 2018: Nutrients
Andrea Döbler, Bea Herbeck Belnap, Hartmut Pollmann, Erik Farin, Heiner Raspe, Oskar Mittag
OBJECTIVE: In this randomized controlled trial, we evaluated the effectiveness of a telephone-delivered intervention based on the Health Action Process Approach (HAPA) after discharge from inpatient rehabilitation to address behavior change, emotional status, and glycemic control in patients with Type 2 diabetes. DESIGN: In a German rehabilitation center, 249 patients with Type 2 diabetes were separated into randomized groups, either a 12-month telephone follow-up support group or the usual care group...
May 2018: Rehabilitation Psychology
Antonin Meyer, Emilie Montastier, Jörg Hager, Wim Hm Saris, Arne Astrup, Nathalie Viguerie, Armand Valsesia
Background: Weight loss in obese individuals aims to reduce the risk of type 2 diabetes by improving glycemic control. Yet, significant intersubject variability is observed and the outcomes remain poorly predictable. Objective: The aim of the study was to predict whether an individual will show improvements in insulin sensitivity above or below the median population change at 6 mo after a low-calorie-diet (LCD) intervention. Design: With the use of plasma lipidomics and metabolomics for 433 subjects from the Diet, Obesity, and Genes (DiOGenes) Study, we attempted to predict good or poor Matsuda index improvements 6 mo after an 8-wk LCD intervention (800 kcal/d)...
June 6, 2018: American Journal of Clinical Nutrition
Verónica Ávila-Rubio, Beatriz García-Fontana, Cristina Novo-Rodríguez, Jesús Cantero-Hinojosa, Rebeca Reyes-García, Manuel Muñoz-Torres
BACKGROUND: Postmenopausal osteoporosis (PMO) is associated with other comorbidities such as impaired glucose homeostasis and cardiovascular disease. Vitamin D insufficiency is highly prevalent and may be a common link between these disorders. However, the relationship between circulating 25-hydroxyvitamin D [25(OH)D] and insulin resistance in women with PMO has not been well evaluated. The aim of this study was to assess the relationship between circulating levels of 25(OH)D and parameters of glucose homeostasis in a cohort of women with PMO to establish a serum concentration threshold of 25(OH)D for improved glycemic parameters...
June 6, 2018: Journal of Women's Health
Nattachet Plengvidhya, Chutima Chanprasert, Nalinee Chongjaroen, Pa-Thai Yenchitsomanus, Mayuree Homsanit, Watip Tangjittipokin
BACKGROUND: Several type 2 diabetes (T2D) susceptibility loci identified via genome-wide association studies were found to be replicated among various populations. However, the influence of these loci on T2D in Thai population is unknown. The aim of this study was to investigate the influence of eight single nucleotide polymorphisms (SNPs) reported in GWA studies on T2D and related quantitative traits in Thai population. METHODS: Eight SNPs in or near the KCNQ1, CDKN2A/2B, SLC30A8, HHEX, CDKAL1, TCF7L2, MTNR1B, and UBE2E2 genes were genotyped...
June 5, 2018: BMC Medical Genetics
David R Luke, Karen Ka Yan Lee, Carl W Rausch, Camille Cheng
BTI320 is a proprietary fractionated mannan polysaccharide being studied for attenuation of postprandial glucose excursion. The apparent blood glucose-lowering effect of this compound is effective in lowering postprandial hyperinsulinemia, participating in the metabolic regulation of other lipid molecules; the consequence of this activity is yet to be validated with BTI320 with respect to the risk of cardiovascular disease. The primary objective of the study was to determine the postprandial glucose and insulin responses to 3 test meals containing rice alone or consumed with BTI320 (study A) or 3 test meals (SpriteTM ) alone or consumed with BTI320 (study B)...
June 5, 2018: Clinical Pharmacology in Drug Development
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