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https://www.readbyqxmd.com/read/29230944/improved-insulin-sensitivity-appears-to-remain-for-a-mean-of-four-years-following-islet-cell-transplant-for-type-1-diabetes
#1
Brett Rydzon, Rebecca S Monson, Jose Oberholzer, Krista A Varady, Melena D Bellin, Kirstie K Danielson
BACKGROUND: Impaired insulin sensitivity (IS) predicts complications and mortality in type 1 diabetes (T1D). IS improves shortly after islet cell transplant for type 1 diabetes, yet long-term changes in IS, and associated factors such as patient characteristics, transplant factors, clinical management, and IS-related biomarkers are unknown. METHODS: Up to nine years (mean four) of longitudinal data were available on 22 adults (18 female) with T1D who received 1-3 transplants in Phase 1/2 or 3 clinical trials (2004-2014)...
December 12, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29228348/flaxseed-supplementation-on-glucose-control-and-insulin-sensitivity-a-systematic-review-and-meta-analysis-of-25-randomized-placebo-controlled-trials
#2
Mohsen Mohammadi-Sartang, Zahra Sohrabi, Reza Barati-Boldaji, Hamidreza Raeisi-Dehkordi, Zohreh Mazloom
Context: The results of human clinical trials investigating the effects of flaxseed on glucose control and insulin sensitivity are inconsistent. Objective: The present study aimed to systematically review and analyze randomized controlled trials assessing the effects of flaxseed consumption on glycemic control. Data Sources: PubMed, Medline via Ovid, SCOPUS, EMBASE, and ISI Web of Sciences databases were searched up to November 2016. Study Selection: Clinical trials in which flaxseed or its products were administered as an intervention were included...
December 8, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/29225893/a-novel-approach-to-glycemic-control-in-type-2-diabetes-mellitus-partial-jejunal-diversion-pre-clinical-to-clinical-pathway
#3
Martin Fried, Karin Dolezalova, Adam P Chambers, Elliott J Fegelman, Robin Scamuffa, Michael L Schwiers, Jason R Waggoner, Martin Haluzik, Randy J Seeley
Objective: To explore partial jejunal diversion (PJD) via a side-to-side jejuno-jejunostomy for improved glycemic control in type 2 diabetes mellitus (T2DM). PJD is an anatomy-sparing, technically simple surgery in comparison to the predominate metabolic procedures, Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG). Positive results in a rodent model prompted a human proof-of-concept study. Research design and methods: Pre-clinically, 71 rats were studied in a model of metabolic dysfunction induced by a high-fat diet; 33 animals undergoing one of two lengths of PJD were compared with 18 undergoing sham, 10 RYGB and 10 jejuno-ileal bypass...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29225844/hemoglobin-providence-%C3%AE-82-lys-asn-asp-and-lower-than-expected-hba1c-in-a-nonadherent-teenager-with-type-1-diabetes-a-case-report-and-literature-review
#4
Charles N Newman, Christine M Litwin, Deborah A Bowlby, Katherine A Lewis, Remberto C Paulo
Endocrinologists should have a high index of suspicion for a Hb variant when the HbA1c is not consistent with other indices of glycemic control.
December 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29225209/dapagliflozin-reduces-fat-mass-without-affecting-muscle-mass-in-type-2-diabetes
#5
Seigo Sugiyama, Hideaki Jinnouchi, Noboru Kurinami, Kunio Hieshima, Akira Yoshida, Katsunori Jinnouchi, Hiroyuki Nishimura, Tomoko Suzuki, Fumio Miyamoto, Keizo Kajiwara, Tomio Jinnouchi
AIM: Sodium-glucose co-transporter 2 inhibitor (SGLT2i) therapy has been demonstrated to improve glycemic control and reduce body weight and fat mass in type 2 diabetes mellitus (T2DM). Here, our aim was to investigate the effects of SGLT2i dapagliflozin-treatment on body muscle mass and muscle fat content in patients with T2DM. METHODS: We prospectively recruited uncontrolled (hemoglobin A1c [HbA1c] >7%) Japanese T2DM patients who had a body mass index (BMI) <35 kg/m2...
December 8, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29224485/assessment-of-dietary-factors-dietary-practices-and-exercise-on-mental-distress-in-young-adults-versus-matured-adults-a-cross-sectional-study
#6
Lina Begdache, Maher Chaar, Nasim Sabounchi, Hamed Kianmehr
The importance of the diet in modulating mental health is uncovering as many dietary factors have been described to alter brain chemistry. Brain maturation may not complete until the age of 30 which may explain the differential emotional control, mindset, and resilience between young adults and matured adults. As a result, dietary factors may influence mental health differently in these two populations. OBJECTIVES: To study dietary intake, dietary practices and exercise in young adults (YA) (18-29 years) versus matured adults (MA) (30 years and older) in relation to mental distress...
December 11, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29224109/testosterone-therapy-and-glucose-homeostasis-in-men-with-testosterone-deficiency-hypogonadism
#7
Farid Saad
Since the early 1990s, it has been recognized that testosterone (T) levels are lower in men with type 2 diabetes mellitus (T2DM) compared with nondiabetic men (controls). Hypogonadism has been reported in approximately 50% of men with T2DM with robust correlations with measures of obesity, such as waist circumference and body mass index (BMI). In longitudinal studies, hypogonadism has been identified as a predictor of incident T2DM. Experimental withdrawal of T led to acute decreased insulin sensitivity, which can be reversed by normalization of T concentrations...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29223421/a-prospective-multi-institutional-cohort-study-of-mediastinal-infections-after-cardiac-operations
#8
Louis P Perrault, Katherine A Kirkwood, Helena L Chang, John C Mullen, Brian C Gulack, Michael Argenziano, Annetine C Gelijns, Ravi K Ghanta, Bryan A Whitson, Deborah L Williams, Nancy M Sledz-Joyce, Brian Lima, Giampaolo Greco, Nishit Fumakia, Eric A Rose, John D Puskas, Eugene H Blackstone, Richard D Weisel, Michael E Bowdish
BACKGROUND: Mediastinal infections are a potentially devastating complication of cardiac operations. This study analyzed the frequency, risk factors, and perioperative outcomes of mediastinal infections after cardiac operations. METHODS: In 2010, 5,158 patients enrolled in a prospective study evaluating infections after cardiac operations and their effect on readmissions and mortality for up to 65 days after the procedure. Clinical and demographic characteristics, operative variables, management practices, and outcomes were compared for patients with and without mediastinal infections, defined as deep sternal wound infection, myocarditis, pericarditis, or mediastinitis...
December 6, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29217651/interleukin-18-serum-level-is-elevated-in-type-2-diabetes-and-latent-autoimmune-diabetes
#9
Emanuela Zaharieva, Zdravko Kamenov, Tsvetelina Velikova, Adelina Tsakova, Yosif El-Darawish, Haruki Okamura
BACKGROUND: Interleukin-18 (IL-18) is an inflammatory cytokine found to be elevated in obesity, metabolic syndrome and type 2 diabetes (T2D) as a part of the chronic low-grade inflammatory process in these states. The aim of the study was to evaluate the interleukin level in patients with latent autoimmune diabetes of the adults (LADA) in comparison to that in T2D subjects. MATERIALS AND METHODS: IL-18 was analyzed through Enzyme-Linked Immunosorbent Assay in 76 participants with T2D and 24 with LADA and 14 control subjects...
December 7, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29216357/parental-history-of-type-2-diabetes-abrogates-ethnic-disparities-in-key-glucoregulatory-indices
#10
Ebenezer Nyenwe, Ibiye Owei, Jim Wan, Sam Dagogo-Jack
Background: There are ethnic differences in glucoregulation and prevalence of type 2 diabetes but studies on the role of genetics in modifying ethnic effects in normoglycemic African-Americans and Caucasians are limited. Therefore, we investigated glucoregulation in normoglycemic African-Americans and Caucasians with or without parental diabetes. Design and Methods: Fifty subjects with parental diabetes (from the POP-ABC cohort) and 50 subjects without parental diabetes were matched in age, sex, ethnicity, and BMI...
December 4, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29215678/decrease-in-mandibular-cortical-in-patients-with-type-1-diabetes-mellitus-combined-with-poor-glycemic-control
#11
Francisco Ivison Rodrigues Limeira, Patrícia Ravena Meneses Rebouças, Denise Nóbrega Diniz, Daniela Pita de Melo, Patrícia Meira Bento
In this study we analyzed the mandibular cortical bone of patients with type 1 diabetes mellitus (T1DM) and non-diabetic. Fifty patients with T1DM and 100 non-diabetic ones paired by age and gender were analyzed. Two double-blinded observers evaluated 150 digital panoramic images of both groups. The mandibular cortical bone was analyzed using the Mandibular Cortical Index (MCI), Mental Index (MI), Gonial Index (GI), Antegonial Index (AI) and Upper and Lower Panoramic Mandibular Indexes (UPMI and LPMI), with the aid of RADIOIMP® software...
September 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29215189/dapagliflozin-as-add-on-therapy-in-asian-patients-with-type-2-diabetes-inadequately-controlled-on-insulin-%C3%A2-oral-antihyperglycemic-drugs-a-randomized-controlled-trial
#12
Wenying Yang, Jianhua Ma, Yiming Li, Yanbing Li, Zhiguang Zhou, Jae Hyeon Kim, June Zhao, Agata Ptaszynska
BACKGROUND: This 24-week, phase 3, double-blind, placebo-controlled study (NCT02096705) assessed the safety and efficacy of dapagliflozin as add-on to insulin ± oral antihyperglycemic drugs (OADs) in Asian patients with inadequately controlled type 2 diabetes. METHODS: Patients (adults; HbA1c ≥7.5-≤10.5%; body mass index ≤45 kg/m2 ; insulin dose ≥20 IU daily) were randomized to dapagliflozin 10 mg (N=139) or placebo (N=133) to assess the 24-week change in HbA1c (primary outcome), fasting plasma glucose (FPG), body weight, total daily dose of insulin (TDDI), and seated systolic blood pressure (SeSBP; exploratory outcome)...
December 7, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/29211027/dietary-intake-of-protein-from-different-sources-and-weight-regain-changes-in-body-composition-and-cardiometabolic-risk-factors-after-weight-loss-the-diogenes-study
#13
Marleen A van Baak, Thomas M Larsen, Susan A Jebb, Alfredo Martinez, Wim H M Saris, Teodora Handjieva-Darlenska, Anthony Kafatos, Andreas F H Pfeiffer, Marie Kunešová, Arne Astrup
An increase in dietary protein intake has been shown to improve weight loss maintenance in the DIOGenes trial. Here, we analysed whether the source of the dietary proteins influenced changes in body weight, body composition, and cardiometabolic risk factors during the weight maintenance period while following an energy-restricted diet. 489 overweight or obese participants of the DIOGenes trial from eight European countries were included. They successfully lost >8% of body weight and subsequently completed a six month weight maintenance period, in which they consumed an ad libitum diet varying in protein content and glycemic index...
December 6, 2017: Nutrients
https://www.readbyqxmd.com/read/29210193/islet-damage-during-isolation-as-assessed-by-mirnas-and-the-correlation-of-mirna-levels-with-posttransplant-outcome-in-islet-autotransplantation
#14
Prathab Balaji Saravanan, Mazhar A Kanak, Charles A Chang, Carly Darden, Gumpei Yoshimatsu, Michael C Lawrence, Bashoo Naziruddin
High-quality pancreatic islets are essential for better posttransplant endocrine function in total pancreatectomy with islet autotransplantation (TPIAT), yet stress during the isolation process affects quality and yield. We analyzed islet-enriched miRNAs -375 and -200c released during isolation to assess damage and correlated the data with posttransplant endocrine function. The absolute concentration of miR-375, miR-200c, and C-peptide was measured in various islet isolation steps, including digestion, dilution, recombination, purification, and bagging, in 12 cases of TPIAT...
December 6, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/29204855/achieving-good-glycemic-control-early-after-onset-of-diabetes-a-cost-effectiveness-analysis-in-patients-with-type-1-diabetes-in-sweden
#15
Johan Jendle, Åsa Ericsson, Barnaby Hunt, William J Valentine, Richard F Pollock
INTRODUCTION: Sweden has amongst the highest incidence rates of type 1 diabetes (T1D) in Europe. The high incidence and chronic nature of T1D result in high prevalence and economic burden. Improving glycemic control reduces the incidence of microvascular complications, which in turn reduces medical costs. The present study aimed to quantify the reductions in cost and improvements in quality-adjusted life expectancy with varying reductions in HbA1c in the T1D population. METHODS: The IQVIA CORE Diabetes Model was used to simulate a typical Swedish population of patients with T1D experiencing HbA1c reductions from 0...
December 4, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29203347/effect-of-dry-heat-treatment-on-physical-property-and-in-vitro-starch-digestibility-of-high-amylose-rice-starch
#16
Im Kyung Oh, In Young Bae, Hyeon Gyu Lee
The influence of dry heat treatment (DHT) of high amylose rice starch was investigated on starch digestibility and physical properties and their characteristics were compared through the PCA analysis. High amylose rice starch was prepared by DHT under different temperatures (110, 130, and 150°C) and times (0, 1, 2, and 4hours). The gelatinization temperature and enthalpy decreased as temperature and time increased, revealing the change of semi-crystalline region. There were significant increases in gel strength and pasting viscosity above 130°C, whereas gel strength and pasting viscosity were reduced with increasing heating time...
December 1, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29203235/sensibility-and-specificity-of-laser-speckle-contrast-imaging-according-to-endo-pat-index-in-type-1-diabetes
#17
Alessandra S de M Matheus, Maria de Fátima Bevilacqua da Matta, Eliete Leão Silva Clemente, Maria de Lourdes Guimarães Rodrigues, Débora Cristina Torres Valença, Marília B Gomes
OBJECTIVES: To find out an normality value for microvascular response (physiological and pharmacological) assessed through laser speckle contrast imaging (LSCI) based on Endo-PAT, which identifies the ones with Endothelial Dysfunction (ED) in patients with Type 1 Diabetes (T1D). METHODS: Patients with T1D, aged ≥12years underwent a clinical-epidemiological questionnaire. Fasting blood samples were obtained (lipid profile, glycemic control and levels of C-reactive protein)...
December 1, 2017: Microvascular Research
https://www.readbyqxmd.com/read/29200722/in-vitro-and-in-vivo-postprandial-glycemic-activity-of-citrus-limetta-peel-flour
#18
José Miguel Flores-Fernández, Carla Patricia Barragán-Álvarez, Nestor Emmanuel Díaz-Martínez, Socorro Villanueva-Rodríguez, Eduardo Padilla-Camberos
Background: Previous studies of Citrus spp. peel have shown hypoglycemic and antioxidant activities. Citrus limetta has been studied for its therapeutic properties. Diabetes mellitus (DM) is a health problem in Mexico and worldwide, that takes a vital importance due to its high incidence. Recently, scientists have searched natural sources to control the disease. Materials and Methods: In this study, we evaluated the in vitro hypoglycemic activity and in vivo postprandial glycemic effect of C...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29200555/erectile-dysfunction-an-underestimated-presentation-in-patients-with-diabetes-mellitus
#19
Zeeshan Anwar, Vishal Sinha, Sayantanava Mitra, Ashwani Kumar Mishra, Mahboobul Hasan Ansari, Abhishek Bharti, Vipin Kumar, Ashwini Kumar Nigam
Introduction: Erectile dysfunction (ED) is a common complication of diabetes mellitus. ED, like other sexual disorders, is often under-reported and under-diagnosed, as talking about sex is considered a taboo in our society. Methodology: All the male patients with diabetes mellitus (with or without active complaints of ED) attending Medicine or Psychiatry OPD of the institute during the study period were enrolled in the study. They were investigated for their body-mass index (BMI), blood sugar and lipid profile; and were assessed on HAM-D, General Health Questionnaire-30, IIEF, sex myth checklist and QOL Instrument for Indian Diabetes Patients (QOLID)...
September 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29198994/dietary-quality-and-markers-of-inflammation-no-association-in-youth-with-type-1-diabetes
#20
Angela D Liese, Xiaonan Ma, Xiaoguang Ma, Murray A Mittleman, Natalie S The, Debra A Standiford, Jean M Lawrence, Catherine Pihoker, Santica M Marcovina, Elizabeth J Mayer-Davis, Robin C Puett
BACKGROUND: Systemic inflammation is a key process underlying cardiovascular disease (CVD) development, and CVD risk is significantly elevated in persons with type 1 diabetes (T1D). Youth with T1D exhibit increased levels of inflammation. Studies in persons without diabetes suggest that dietary quality influences inflammation, yet little is known about dietary influences on inflammation in youth with T1D. METHODS: This study evaluated the association of four distinct dietary quality indices (Dietary Approaches to Stop Hypertension (DASH), Healthy Eating Index 2010 (HEI2010), modified KIDMED and Total Antioxidant Capacity (TAC)) with biomarkers of inflammation (C-reactive protein (CRP), fibrinogen and interleukin-6 (IL-6)) in a sample of 2520 youth with T1D participating in the SEARCH for Diabetes in Youth Study...
November 6, 2017: Journal of Diabetes and its Complications
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