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https://www.readbyqxmd.com/read/29161394/managing-anaesthetic-provision-for-global-disasters
#1
R M Craven
The numbers of people affected by large-scale disasters has increased in recent decades. Disasters produce a huge burden of surgical morbidity at a time when the affected country is least able to respond. For this reason an international disaster response is often required. For many years this disaster response was not coordinated. The response consisted of what was available not what was needed and standards of care varied widely producing a healthcare lottery for the affected population. In recent years the World Health organisation has initiated the Emergency Medical Team programme to coordinate the response to disasters and set minimum standards for responding teams...
December 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29161089/protein-folding-and-the-challenges-of-maintaining-endoplasmic-reticulum-proteostasis-in-idiopathic-pulmonary-fibrosis
#2
Freddy Romero, Ross Summer
Alveolar epithelial type II (AEII) cells are "professional" secretory cells that synthesize and secrete massive quantities of proteins to produce pulmonary surfactant and maintain airway immune defenses. To facilitate this high level of protein synthesis, AEII cells are equipped with an elaborate endoplasmic reticulum (ER) structure and possess an abundance of the machinery needed to fold, assemble, and secrete proteins. However, conditions that suddenly increase the quantity of new proteins entering the ER or that impede the capacity of the ER to fold proteins can cause misfolded or unfolded proteins to accumulate in the ER lumen, also called ER stress...
November 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29152819/the-application-of-systems-thinking-concepts-methods-and-tools-to-global-health-practices-an-analysis-of-case-studies
#3
Jessica Wilkinson, Morgan Goff, Evan Rusoja, Carl Hanson, Robert Chad Swanson
OBJECTIVES: This review of systems thinking (ST) case studies seeks to compile and analyse cases from ST literature and provide practitioners with a reference for ST in health practice. Particular attention was given to (1) reviewing the frequency and use of key ST terms, methods, and tools in the context of health, and (2) extracting and analysing longitudinal themes across cases. METHODS: A systematic search of databases was conducted, and a total of 36 case studies were identified...
November 20, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29148074/salutogenic-healthy-aging-programme-embracement-shape-for-senior-only-households-a-study-protocol
#4
Betsy Seah, Yanika Kowitlawakul, Srinivasan Chokkanathan, Jeane Jin Yi Fong, Geir Arild Espnes, Emily Ang, Wenru Wang
AIMS: To evaluate the effectiveness of a multi-dimensional community-based health promotion and risk prevention program, named Salutogenic Healthy Aging Program Embracement (SHAPE) for senior-only households in Singapore. BACKGROUND: In view of aging population and its significant impacts on economy, societal structure and policy-making, healthy aging emerges as an important concept in maintaining health through the engagement of health-promoting behaviour and risk-prevention actions in older people...
November 17, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29145021/production-of-chemicals-using-dynamic-control-of-metabolic-fluxes
#5
REVIEW
Peng Xu
Engineered microbial cell factories are constantly experiencing metabolic imbalance due to nutrients depletion, metabolites buildup, evolutionary pressure or genetic instability. It is important to equip the engineered cell factory with sensor-regulator system to enable cell adjust metabolism and respond to the changing environment. Dynamically allocating cellular resources and optimally controlling pathway expression have proved as promising strategies to manage the tradeoff between cell growth and product formation as well as improve the cost-competitiveness of industrial fermentation...
November 13, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/29141663/quality-assurance-of-the-scope-1-trial-in-oesophageal-radiotherapy
#6
Lucy Wills, Rhydian Maggs, Geraint Lewis, Gareth Jones, Lisette Nixon, John Staffurth, Tom Crosby
BACKGROUND: SCOPE 1 was the first UK based multi-centre trial involving radiotherapy of the oesophagus. A comprehensive radiotherapy trials quality assurance programme was launched with two main aims: 1. To assist centres, where needed, to adapt their radiotherapy techniques in order to achieve protocol compliance and thereby enable their participation in the trial. 2. To support the trial's clinical outcomes by ensuring the consistent planning and delivery of radiotherapy across all participating centres...
November 15, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29131460/pilot-study-on-the-effectiveness-and-students-attitude-towards-undergraduate-training-provided-by-industry
#7
M Karl, M Franz, T Grobecker-Karl, M Scheib
INTRODUCTION: Rapid developments in CAD/CAM technology necessitate the adaptation of curriculum content. Limited resources hinder institutions in holding state of the art equipment available for student training. MATERIALS AND METHODS: A workshop given by an industry partner was organised as part of the final pre-clinical course in prosthodontics for the academic years 2015 and 2016. The workshop on dental ceramics and CAD/CAM technology comprised of lectures and practical demonstrations...
November 13, 2017: European Journal of Dental Education: Official Journal of the Association for Dental Education in Europe
https://www.readbyqxmd.com/read/29130143/incorporating-social-media-into-your-support-tool-box-points-to-consider-from-genetics-based-communities
#8
Heather Mae Rocha, Juliann M Savatt, Erin Rooney Riggs, Jennifer K Wagner, W Andrew Faucett, Christa Lese Martin
Patients with newly-described or rare genetic findings are turning to social media to find and connect with others. Blogs, Facebook groups, and Twitter have all been reported as tools for patients to connect with one another. However, the preferences for social media use and privacy among patients, their families, and these communities have not been well characterized. To explore preferences about privacy and membership guidelines, an online survey was administered to two web-based patient registries, Simons Variation in Individuals Project ( www...
November 13, 2017: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/29127895/moving-nurse-educators-towards-transcendence-in-simulation-comfort
#9
Tracey Simes, Sherre Roy, Barbara O'Neill, Colleen Ryan, Samuel Lapkin, Elizabeth Curtis
Expensive simulation equipment continues to sit idle in nursing learning and teaching environments. To identify factors that influence nursing educator comfort in the use of simulation at an Australian university an explorative qualitative research project was undertaken using an interpretative constructivist methodology. The Goodwin et al. (2007) adapted Comfort Theory for nursing education has been used. The aim of the study was to identify factors that influence nurse educator's comfort in the use of simulation...
October 19, 2017: Nurse Education in Practice
https://www.readbyqxmd.com/read/29124018/improved-high-throughput-quantification-of-luminescent-microplate-assays-using-a-common-western-blot-imaging-system
#10
Liam J Hawkins, Kenneth B Storey
Common Western-blot imaging systems have previously been adapted to measure signals from luminescent microplate assays. This can be a cost saving measure as Western-blot imaging systems are common laboratory equipment and could substitute a dedicated luminometer if one is not otherwise available. One previously unrecognized limitation is that the signals captured by the cameras in these systems are not equal for all wells. Signals are dependent on the angle of incidence to the camera, and thus the location of the well on the microplate...
2017: MethodsX
https://www.readbyqxmd.com/read/29121510/emg-normalization-method-based-on-grade-3-of-manual-muscle-testing-within-and-between-day-reliability-of-normalization-tasks-and-application-to-gait-analysis
#11
Anne Tabard-Fougère, Kevin Rose-Dulcina, Vincent Pittet, Romain Dayer, Nicolas Vuillerme, Stéphane Armand
Electromyography (EMG) is an important parameter in Clinical Gait Analysis (CGA), and is generally interpreted with timing of activation. EMG amplitude comparisons between individuals, muscles or days need normalization. There is no consensus on existing methods. The gold standard, maximum voluntary isometric contraction (MVIC), is not adapted to pathological populations because patients are often unable to perform an MVIC. The normalization method inspired by the isometric grade 3 of manual muscle testing (isoMMT3), which is the ability of a muscle to maintain a position against gravity, could be an interesting alternative...
November 4, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29119446/nano-micro-formulations-for-bacteriophage-delivery
#12
Pilar Cortés, Mary Cano-Sarabia, Joan Colom, Jennifer Otero, Daniel Maspoch, Montserrat Llagostera
Encapsulation methodologies allow the protection of bacteriophages for overcoming critical environmental conditions. Moreover, they improve the stability and the controlled delivery of bacteriophages which is of great innovative value in bacteriophage therapy. Here, two different encapsulation methodologies of bacteriophages are described using two biocompatible materials: a lipid cationic mixture and a combination of alginate with the antacid CaCO3. To perform bacteriophage encapsulation, a purified lysate highly concentrated (around 10(10)-10(11) pfu/mL) is necessary, and to dispose of a specific equipment...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29116520/next-generation-dna-sequencing-of-vh-vl-repertoires-a-primer-and-guide-to-applications-in-single-domain-antibody-discovery
#13
Kevin A Henry
Immunogenetic analyses of expressed antibody repertoires are becoming increasingly common experimental investigations and are critical to furthering our understanding of autoimmunity, infectious disease, and cancer. Next-generation DNA sequencing (NGS) technologies have now made it possible to interrogate antibody repertoires to unprecedented depths, typically by sequencing of cDNAs encoding immunoglobulin variable domains. In this chapter, we describe simple, fast, and reliable methods for producing and sequencing multiplex PCR amplicons derived from the variable regions (VH, VHH or VL) of rearranged immunoglobulin heavy and light chain genes using the Illumina MiSeq platform...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29114617/two-and-a-half-year-clinical-experience-with-the-world-s-first-magnetic-resonance-image-guided-radiation-therapy-system
#14
Benjamin W Fischer-Valuck, Lauren Henke, Olga Green, Rojano Kashani, Sahaja Acharya, Jeffrey D Bradley, Clifford G Robinson, Maria Thomas, Imran Zoberi, Wade Thorstad, Hiram Gay, Jiayi Huang, Michael Roach, Vivian Rodriguez, Lakshmi Santanam, Harold Li, Hua Li, Jessika Contreras, Thomas Mazur, Dennis Hallahan, Jeffrey R Olsen, Parag Parikh, Sasa Mutic, Jeff Michalski
Purpose: Magnetic resonance image guided radiation therapy (MR-IGRT) has been used at our institution since 2014. We report on more than 2 years of clinical experience in treating patients with the world's first MR-IGRT system. Methods and materials: A clinical service was opened for MR-IGRT in January 2014 with an MR-IGRT system consisting of a split 0.35T magnetic resonance scanner that straddles a ring gantry with 3 multileaf collimator-equipped (60)Co heads...
July 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29114122/dot-enzyme-linked-immunosorbent-assay-elisa-for-the-detection-of-toxocara-infection-using-a-rat-model
#15
Vachel Gay V Paller, Cyrelle M Besana, Isabel Kristine M Valdez
Toxocariasis is a zoonotic disease usually caused by dog and cat roundworms, Toxocara canis and T. cati. Detection and diagnosis is difficult in paratenic and accidental hosts, including humans, as they cannot be detected through conventional methods such as fecal examination. Diagnosis therefore relies on immunological methods and molecular methods such as enzyme-linked immunosorbent assay (ELISA) and Western Blot, which are both time-consuming and requires sophisticated equipment. In the Philippines, only a few studies are available on Toxocara seroprevalence...
December 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/29113087/an-energy-efficient-adaptive-sampling-algorithm-in-a-sensor-network-for-automated-water-quality-monitoring
#16
Tongxin Shu, Min Xia, Jiahong Chen, Clarence de Silva
Power management is crucial in the monitoring of a remote environment, especially when long-term monitoring is needed. Renewable energy sources such as solar and wind may be harvested to sustain a monitoring system. However, without proper power management, equipment within the monitoring system may become nonfunctional and, as a consequence, the data or events captured during the monitoring process will become inaccurate as well. This paper develops and applies a novel adaptive sampling algorithm for power management in the automated monitoring of the quality of water in an extensive and remote aquatic environment...
November 5, 2017: Sensors
https://www.readbyqxmd.com/read/29107988/basic-emotions-and-adaptation-a-computational-and-evolutionary-model
#17
Daniela Pacella, Michela Ponticorvo, Onofrio Gigliotta, Orazio Miglino
The core principles of the evolutionary theories of emotions declare that affective states represent crucial drives for action selection in the environment and regulated the behavior and adaptation of natural agents in ancestrally recurrent situations. While many different studies used autonomous artificial agents to simulate emotional responses and the way these patterns can affect decision-making, few are the approaches that tried to analyze the evolutionary emergence of affective behaviors directly from the specific adaptive problems posed by the ancestral environment...
2017: PloS One
https://www.readbyqxmd.com/read/29102826/a-motion-tolerant-approach-for-monitoring-spo2-and-heart-rate-using-photoplethysmography-signal-with-dual-frame-length-processing-and-multi-classifier-fusion
#18
Feiyi Fan, Yuepeng Yan, Yongzhong Tang, Hao Zhang
Monitoring pulse oxygen saturation (SpO2) and heart rate (HR) using photoplethysmography (PPG) signal contaminated by a motion artifact (MA) remains a difficult problem, especially when the oximeter is not equipped with a 3-axis accelerometer for adaptive noise cancellation. In this paper, we report a pioneering investigation on the impact of altering the frame length of Molgedey and Schuster independent component analysis (ICAMS) on performance, design a multi-classifier fusion strategy for selecting the PPG correlated signal component, and propose a novel approach to extract SpO2 and HR readings from PPG signal contaminated by strong MA interference...
November 2, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29102097/management-of-an-entrapped-patient-with-a-field-amputation
#19
John C Bunyasaranand, Erasmo Espino, Kelli A Rummings, Gregory M Christiansen
BACKGROUND: Emergency surgical amputations are rare and resource-intensive lifesaving interventions. Most emergency medical services (EMS) lack a formal protocol to manage these high-risk but low-occurrence events. There has been limited attention in the EMS community to address this issue. Without a literature-based approach, the EMS community has been offered little guidance on managing surgical field amputations. CASE REPORT: A 38-year-old man was terminally entrapped below the waist in an industrial auger...
October 25, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29096225/effects-of-16-weeks-of-pilates-on-health-perception-and-sleep-quality-among-elderly-women
#20
V S Curi, J Vilaça, A N Haas, H M Fernandes
The objective of this study was to determine the effect of 16 weeks of mat-based Pilates training on health perception and sleep quality among elderly women. A randomized and controlled trial was conducted in Caxias do Sul, Brazil, in 2015, in which 61 healthy older women were divided into two groups: experimental group (EG; n=31, average of 64.25 years old, SD 0.14) and control group (CG; n=30, average of 63.75 years old, SD 0.08). The EG participants performed mat-based Pilates exercises twice a week in 60-min sessions, whereas the CG did not train...
October 30, 2017: Archives of Gerontology and Geriatrics
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