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https://www.readbyqxmd.com/read/29781791/the-facilitators-and-challenges-of-dying-at-home-with-dementia-a-narrative-synthesis
#1
Caroline Mogan, Mari Lloyd-Williams, Karen Harrison Dening, Christopher Dowrick
BACKGROUND: It is reported that, given the right support, most people would prefer to die at home, yet a very small minority of people with dementia do so. At present, knowledge gaps remain on how best to support end-of-life care at home for people with dementia. AIM: To identify and understand the challenges and facilitators of providing end-of-life care at home for people with dementia. DESIGN: Narrative synthesis of qualitative and quantitative data...
June 2018: Palliative Medicine
https://www.readbyqxmd.com/read/29772673/reducing-amputations-in-people-with-diabetes-rapid-evaluation-of-a-new-care-pathway
#2
Sandra MacRury, Kate Stephen, Fiona Main, Jane Gorman, Sandra Jones, David Macfarlane
People with diabetes are at increased risk of foot ulcers, which, if left untreated, can lead to infection, gangrene, and subsequent amputation. Management by a multidisciplinary diabetes foot team has been shown to reduce amputation rates; however, accessing specialist treatment is made particularly difficult when living in remote and rural locations, such as many individuals cared for within NHS Highland. The RAPID project was made up of two phases: firstly, to evaluate the technical feasibility of a new integrated care pathway using innovative technology, and secondly, to establish process enhancement of the pathway to justify a larger-scale study...
May 16, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29769399/dissecting-and-culturing-animal-cap-explants
#3
Kevin S Dingwell, James C Smith
The animal cap explant is a simple but adaptable tool available to developmental biologists. The use of animal cap explants in demonstrating the presence of mesoderm-inducting activity in the Xenopus embryo vegetal pole is one of many elegant examples of their worth. Animal caps respond to a range of growth factors (e.g., Wnts, FGF, TGF-β), making them especially useful for studying signal transduction pathways and gene regulatory networks. Explants are also suitable for examining cell behavior and have provided key insights into the molecular mechanisms controlling vertebrate morphogenesis...
May 16, 2018: Cold Spring Harbor Protocols
https://www.readbyqxmd.com/read/29764173/developing-palliative-care-programs-in-indigenous-communities-using-participatory-action-research-a-canadian-application-of-the-public-health-approach-to-palliative-care
#4
Mary Lou Kelley, Holly Prince, Shevaun Nadin, Kevin Brazil, Maxine Crow, Gaye Hanson, Luanne Maki, Lori Monture, Christopher J Mushquash, Valerie O'Brien, Jeroline Smith
BACKGROUND: The Indigenous people of Canada include First Nations, Inuit and Metis. This research focused on four diverse First Nations communities located in Ontario and Manitoba. First Nations communities have well-established culturally-based social processes for supporting their community members experiencing dying, loss, grief and bereavement. However, communities do not have formalized local palliative care (PC) programs and have limited access to medical services, especially pain and symptom management...
April 2018: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/29763356/chairside-cad-cam-composite-onlays-for-the-restoration-of-primary-molars
#5
Elisabeth Dursun, Aude Monnier-Da Costa, Christian Moussally
After pulp therapy or with multi-surface caries in primary molars, pre-formed stainless steel crowns are usually placed to ensure tooth longevity. Esthetic alternatives, such as zirconia crowns, have been proposed, but they are invasive. Here we describe two cases of chairside computer-aided design and computer-aided manufacturing (CAD/CAM) technology used to treat extended and/or deep caries on primary molars. A powder-free chairside CAD/CAM system, a milling unit and machinable high-performance composite blocks were used...
May 15, 2018: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/29763271/adults-with-developmental-disabilities-a-comprehensive-approach-to-medical-care
#6
Clarissa Kripke
Developmental disabilities are attributable to a cognitive impairment, physical impairment, or both. They manifest during the developmental period from birth to early adulthood, and are likely to continue indefinitely. The life expectancy of most persons with developmental disabilities now approaches that of the general population. According to the neurodiversity model of care, developmental disability is accepted as a valued part of human neurologic diversity. The social model focuses on improving participation in society with accommodations such as adaptive equipment or improvements to the social and physical environment...
May 15, 2018: American Family Physician
https://www.readbyqxmd.com/read/29758683/markovian-robots-minimal-navigation-strategies-for-active-particles
#7
Luis Gómez Nava, Robert Großmann, Fernando Peruani
We explore minimal navigation strategies for active particles in complex, dynamical, external fields, introducing a class of autonomous, self-propelled particles which we call Markovian robots (MR). These machines are equipped with a navigation control system (NCS) that triggers random changes in the direction of self-propulsion of the robots. The internal state of the NCS is described by a Boolean variable that adopts two values. The temporal dynamics of this Boolean variable is dictated by a closed Markov chain-ensuring the absence of fixed points in the dynamics-with transition rates that may depend exclusively on the instantaneous, local value of the external field...
April 2018: Physical Review. E
https://www.readbyqxmd.com/read/29757774/can-telerehabilitation-games-lead-to-functional-improvement-of-upper-extremities-in-individuals-with-parkinson-s-disease
#8
Imre Cikajlo, Alma Hukić, Irena Dolinšek, Dejana Zajc, Mateja Vesel, Tatjana Krizmanič, Bojan Blažica, Anton Biasizzo, Franc Novak, Karmen Peterlin Potisk
Parkinson's disease (PD) is treated by medication, less with deep brain stimulation and physiotherapy. Different opinions on the clinical meaningfulness of the physiotherapy or recommended intensive physiotherapy were found. Our objectives were to design intensive target-based physiotherapy for upper extremities suitable for telerehabilitation services and examine the clinical meaningfulness of the exergaming at an unchanged medication plan. A telerehabilitation exergaming system using the Kinect sensor was developed; 28 patients with PD participated in the study...
May 4, 2018: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/29757238/the-initiation-of-th2-immunity-towards-food-allergens
#9
REVIEW
Yosef Ellenbogen, Rodrigo Jiménez-Saiz, Paul Spill, Derek K Chu, Susan Waserman, Manel Jordana
In contrast with Th1 immune responses against pathogenic viruses and bacteria, the incipient events that generate Th2 responses remain less understood. One difficulty in the identification of universal operating principles stems from the diversity of entities against which cellular and molecular Th2 responses are produced. Such responses are launched against harmful macroscopic parasites and noxious substances, such as venoms, but also against largely innocuous allergens. This suggests that the established understanding about sense and recognition applied to Th1 responses may not be translatable to Th2 responses...
May 12, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29752907/effectiveness-of-the-pilates-method-in-the-treatment-of-chronic-mechanical-neck-pain-a-randomized-controlled-trial
#10
Luciana de Araujo Cazotti, Anamaria Jones, Diego Roger-Silva, Luiza Helena Coutinho Ribeiro, Jamil Natour
OBJECTIVE: To assess the effectiveness of the Pilates method on pain, function, quality of life, and consumption of pain medication in patients with mechanical neck pain. DESIGN: The design was a randomized controlled trial, with a blinded assessor and intention-to-treat analysis. SETTING: The study took place in the outpatient clinic of the rheumatology department, referral center. PARTICIPANTS: Sixty-four patients with chronic mechanical neck pain were randomly allocated into 2 groups: the Pilates group (PG) and control group (CG)...
May 9, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29752826/post-polio-syndrome-and-the-late-effects-of-poliomyelitis-part-2-treatment-management-and-prognosis
#11
REVIEW
Julian K Lo, Lawrence R Robinson
Post-Polio Syndrome (PPS) is characterized by new muscle weakness and/or muscle fatigability that occurs many years following the initial poliomyelitis illness. An individualized approach to rehabilitation management is critical. Interventions may include rehabilitation management strategies, adaptive equipment, orthotic equipment, gait/mobility aids and a variety of therapeutic exercises. The progression of muscle weakness in PPS is typically slow and gradual; however, there is also variability in both the natural history of weakness and functional prognosis...
May 12, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29749697/canine-and-feline-fundus-photography-and-videography-using-a-nonpatented-3d-printed-lens-adapter-for-a-smartphone
#12
Filipe Espinheira Gomes, Eric Ledbetter
OBJECTIVE: To describe an indirect funduscopy imaging technique for dogs and cats using low cost and widely available equipment: a smartphone, a three-dimensional (3D) printed indirect lens adapter, and a 40 diopters (D) indirect ophthalmoscopy lens. METHODS: Fundus videography was performed in dogs and cats using a 40D indirect ophthalmoscopy lens and a smartphone fitted with a 3D printed indirect lens adapter. All animals were pharmacologically dilated with topical tropicamide 1% solution...
May 11, 2018: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/29747525/providing-care-for-a-person-with-late-stage-dementia-at-home-what-are-carers-experiences
#13
Laura Dempsey, Maura Dowling, Philip Larkin, Kathy Murphy
Background It is widely reported that carers who provide care for a family member with dementia endure physical and psychological burdens. Not only do they fulfil an important role for the person with dementia but also for the wider society. This study aims to explore the experiences of carers who provide end-of-life care for a person with late-stage dementia at home. Method Semi-structured interviews were conducted with 17 current carers and 6 past carers of a family member with late-stage dementia. Data was analysed using interpretative phenomenological analysis...
January 1, 2018: Dementia
https://www.readbyqxmd.com/read/29746889/modular-auditory-decision-making-behavioral-task-designed-for-intraoperative-use-in-humans
#14
Anand Tekriwal, Gidon Felsen, John A Thompson
BACKGROUND: Neurosurgical interventions that require active patient feedback, such as deep brain stimulation surgery, create an opportunity to conduct cognitive or behavioral experiments during the acquisition of invasive neurophysiology. Optimal design and implementation of intraoperative behavioral experiments require consideration of stimulus presentation, time and surgical constraints. We describe the use of a modular, inexpensive system that implements a decision-making paradigm, designed to overcome challenges associated with the operative environment...
May 7, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29746092/metabolic-recruitment-and-directed-evolution-of-nucleoside-triphosphate-uptake-in-escherichia-coli
#15
Valerie Pezo, Camille Hassan, Dominique Louis, Bruno Sargueil, Piet Herdewijn, Philippe Marliere
We report the design and elaboration of a selection protocol for importing a canonical substrate of DNA polymerase, thymidine triphosphate (dTTP) in Escherichia coli. Bacterial strains whose growth depend on dTTP uptake, through the action of an algal plastid transporter expressed from a synthetic gene inserted in the chromosome, were constructed and shown to withstand the simultaneous loss of thymidylate synthase and thymidine kinase. Such thyA tdk dual deletant strains provide an experimental model of tight nutritional containment for preventing dissemination of microbial GMOs...
May 10, 2018: ACS Synthetic Biology
https://www.readbyqxmd.com/read/29745098/quality-assurance-protocol-for-superficial-and-deep-hyperthermia-systems-established-by-the-hellenic-association-of-medical-physicists-hamp-in-cooperation-with-the-hellenic-society-of-oncologic-hyperthemia-hsoh-a-study-based-on-european-society-for-hyperthermic
#16
Sotiria Triantopoulou, Kalliopi Platoni, Christos Antypas, Pantelis Karaiskos, Christina Armpilia, Nikolaos Uzunoglou, Vassilis Kouloulias
PURPOSE: During the last years hyperthermia is a developing therapeutic modality in Greece. Quality assurance (QA) procedures are essential for ensuring the correct operation of the hyperthermia system and therefore the selective heating of the tumor with minimum toxicity to the surrounding healthy tissues. The European Society for Hyperthermic Oncology (ESHO) has proposed QA guidelines for superficial as well as deep hyperthermia systems. The purpose of this study was to describe the adapted QA protocol for superficial and deep hyperthermia systems established in Greece...
March 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29737053/-the-research-advancement-and-conception-of-the-deep-underground-medicine
#17
REVIEW
He-Ping Xie, Ji-Feng Liu, Ming-Zhong Gao, Xue-Hong Wan, Shi-Xi Liu, Jian Zou, Jiang Wu, Teng-Fei Ma, Yi-Lin Liu, Hong Bu, Wei-Min Li
The 21th century is the century of exploring and utilizing the underground space. In the future, more and more people will spend more and more time living or/and working in the underground space. However,we know little about the effect on the health of human caused by the underground environment. Herein,we systematically put forward the strategic conception of the deep-underground medicine,in order to reveal relative effects and mechanism of the potential factors in the deep underground space on human's physiological and psychological healthy,and to work out the corresponding countermeasures...
March 2018: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29733402/the-influence-of-supplemental-zinc-and-ractopamine-hydrochloride-on-trace-mineral-and-nitrogen-retention-of-beef-steers
#18
R N Carmichael, O N Genther-Schroeder, C P Blank, E L Deters, S J Hartman, E K Niedermayer, S L Hansen
The study objective was to determine if N retention was improved with supplemental Zn above NRC concentrations with or without ractopamine hydrochloride inclusion. Angus crossbred steers (n = 32, 485 ± 26 kg BW) with Genemax gain scores of 4 or 5 were utilized in a 2×2 factorial arrangement (8 steers/treatment). Steers were blocked by BW to a finishing diet with one of two mineral supplementation strategies (ZNTRT), no supplemental Zn (analyzed 32 mg Zn/kg DM; CON) or supranutritional Zn (CON + 60 ppm ZnSO4 + 60 ppm Zn-amino acid complex; analyzed 145 mg Zn/kg DM; SUPZN), fed 56 days in pens equipped with Growsafe bunks and assigned to beta agonist (BA) supplementation strategies of 0 (NON) or 300 mg·-1steer·-1d ractopamine hydrochloride (RAC) fed the last 30 d before harvest...
May 4, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29731208/no-359-obstetric-ultrasound-biological-effects-and-safety
#19
Michiel C Van den Hof
OBJECTIVE: To review the biological effects and safety of obstetric ultrasound. OUTCOME: Outline the circumstances in which safety may be a concern with obstetric ultrasound. EVIDENCE: The 2005 version of this guideline was used as a basis and updated following a Medline search and review of relevant publications. Sources included guidelines and reports by Health Canada and the American Institute of Ultrasound in Medicine. VALUES: Review by principal author and the Diagnostic Imaging Committee of the SOGC...
May 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29729684/paramedics-perspectives-on-factors-impacting-on-scene-times-for-trauma-calls
#20
Mark Levitan, Madelyn P Law, Richard Ferron, Karen Lutz-Graul
IntroductionAccording to Ontario, Canada's Basic Life Support Patient Care Standards, Emergency Medical Services (EMS) on-scene time (OST) for trauma calls should not exceed 10 minutes, unless there are extenuating circumstances. The time to definitive care can have a significant impact on the morbidity and mortality of trauma patients. This is the first Canadian study to investigate why this is the case by giving a voice to those most involved in prehospital care: the paramedics themselves. It is also the first study to explore this issue from a complex, adaptive systems approach which recognizes that OSTs may be impacted by local, contextual features...
May 6, 2018: Prehospital and Disaster Medicine
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