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https://www.readbyqxmd.com/read/29352271/sex-disparity-in-cancer-roles-of-micrornas-and-related-functional-players
#1
REVIEW
Alessandra Carè, Maria Bellenghi, Paola Matarrese, Lucia Gabriele, Stefano Salvioli, Walter Malorni
A sexual dimorphism at the cellular level has been suggested to play a role in cancer onset and progression. In particular, very recent studies have unraveled striking differences between cells carrying XX or XY chromosomes in terms of response to stressful stimuli, indicating the presence of genetic and epigenetic differences determining sex-specific metabolic or phenotypic traits. Although this field of investigation is still in its infancy, available data suggest a key role of sexual chromosomes in determining cell life or death...
January 19, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29343571/casein-kinase-1%C3%AE-mediates-degradation-of-receptors-for-type-i-and-type-ii-interferons-caused-by-hemagglutinin-of-influenza-a-virus
#2
Chuan Xia, Jennifer J Wolf, Madhuvanthi Vijayan, Caleb J Studstill, Wenjun Ma, Bumsuk Hahm
Although influenza A virus (IAV) evades cellular defense systems to effectively propagate in the host, the viral immune evasive mechanisms are incompletely understood. Our recent data showed that hemagglutinin (HA) of IAV induces degradation of type I IFN receptor 1 (IFNAR1). Here, we demonstrate that IAV HA induces degradation of type II IFN (IFN-γ) receptor 1 (IFNGR1) as well as IFNAR1 via casein kinase 1α (CK1α), resulting in the impairment of cellular responsiveness to both type I and II IFNs. IAV infection or transient HA expression induced degradation of both IFNGR1 and IFNAR1, whereas HA gene-deficient IAV failed to downregulate the receptors...
January 17, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29337912/social-incentive-mechanism-based-multi-user-sensing-time-optimization-in-co-operative-spectrum-sensing-with-mobile-crowd-sensing
#3
Xiaohui Li, Qi Zhu
Co-operative spectrum sensing emerging as a significant method to improve the utilization of the spectrum needs sufficient sensing users to participate. Existing related papers consider only the limited secondary users in current sensing system and assume that they will always perform the co-operative spectrum sensing out of obligation. However, this assumption is impractical in the realistic situation where the secondary users are rational and they will not join in the co-operative sensing process without a certain reward to compensate their sensing energy consumption, especially the ones who have no data transmitting in current time slot...
January 16, 2018: Sensors
https://www.readbyqxmd.com/read/29331411/tailoring-cyanobacterial-cell-factory-for-improved-industrial-properties
#4
REVIEW
Guodong Luan, Xuefeng Lu
Photosynthetic biomanufacturing provides a promising solution for sustainable production of biofuels and biochemicals. Cyanobacteria are among the most promising microbial platforms for the construction of photosynthetic cell factories. Metabolic engineering of cyanobacteria has enabled effective photosynthetic synthesis of diverse natural or non-natural metabolites, while commercialization of photosynthetic biomanufacturing is usually restricted by process and economic feasibilities. In actual outdoor conditions, active cell growth and product synthesis is restricted to narrow light exposure windows of the day-night cycles and is threatened by diverse physical, chemical, and biological environmental stresses...
January 10, 2018: Biotechnology Advances
https://www.readbyqxmd.com/read/29330801/hypoxic-treatment-of-zebrafish-embryos-and-larvae
#5
Hiroyasu Kamei, Cunming Duan
Zebrafish has emerged as an informative animal model to study the biological impact and molecular mechanisms of hypoxia. Here we describe a simple method to induce hypoxia in zebrafish embryos and larvae. This protocol is easy and reproducible and does not require expensive equipment or specialized devices. It can be adapted in large, medium, and small scales. This protocol is also well-suited for experiments requiring chemical drug treatment and can be applied to other fish and amphibian species.
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29328181/super-resolution-image-de-fencing-using-a-nonlocal-nonconvex-prior
#6
Sankaraganesh Jonna, Sukla Satapathy, Rajiv R Sahay
Today's smartphones/phablets/tablets are equipped with cameras that have enabled people to capture their favorite moments. However, images or videos taken at public places using inexpensive low-resolution cameras are often degraded by the presence of occlusions such as fences/barricades. In order to reconstruct a fence-free high-resolution image, we use a video of a scene captured by panning a hand-held camera and model the effects of various degradations. Initially, we obtain the spatial locations of fences by semantic segmentation and subsequently estimate the subpixel motion between the degraded low-resolution frames...
January 10, 2018: Applied Optics
https://www.readbyqxmd.com/read/29328177/projected-image-correction-technology-research-on-autonomous-perception-anisotropic-surfaces
#7
Fan Yang, Cheng Han, Bao-Xing Bai, Chao Zhang
In this paper, a projection correction method is proposed for autonomous-perception depth anisotropic surfaces, in order to improve the adaptive perceptual projection of the projection equipment under different circumstances. During the parameter calibration process of a projector-camera system with low recognition precision, as well as low noise resistance at angular points, an angular-point subpixel detection algorithm based on color information guidance was proposed to effectively improve the identification precision of the angular-point detection...
January 10, 2018: Applied Optics
https://www.readbyqxmd.com/read/29324929/our-solution-for-fusion-of-simultaneusly-acquired-whole-body-scintigrams-and-optical-images-as-usesful-tool-in-clinical-practice-in-patients-with-differentiated-thyroid-carcinomas-after-radioiodine-therapy-a-useful-tool-in-clinical-practice
#8
Milovan Matovic, Milica Jankovic, Marko Barjaktarovic, Marija Jeremic
OBJECTIVE: After radioiodine therapy of differentiated thyroid cancer (DTC) patients, whole body scintigraphy (WBS) is standard procedure before releasing the patient from the hospital. A common problem is the precise localization of regions where the iod-avide tissue is located. Sometimes is practically impossible to perform precise topographic localization of such regions. METHOD: In order to face this problem, we have developed a low-cost Vision-Fusion system for web-camera image acquisition simultaneously with routine scintigraphic whole body acquisition including the algorithm for fusion of images given from both cameras...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29322713/communication-adaptations-for-a-diverse-international-patient-population
#9
Aditya Ghosh, Shashank Joshi, Amit K Ghosh
We live in an age of hyper connectivity, people from around the world are looking outside their own national borders to receive medical care. As more people are learning about the quality that the elite Indian hospitals provide at a competitive, and often more affordable, price compared to other institutions around the world, they are becoming increasingly interested in receiving their medical care in Indian hospitals. It is for this exact reason that it is very important to learn the importance of communicating effectively with people from a diverse background...
November 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29313472/diagnosis-of-trypanosoma-cruzi-infection-status-using-saliva-of-infected-subjects
#10
Nuria Cortes-Serra, Maria-Jesus Pinazo, Leonardo De la Torre, Melina Galizzi, Joaquim Gascon, Juan Manuel Bustamante
Chagas disease has the highest prevalence of any parasitic disease in the Americas, affecting 6-7 million people. Conventional diagnosis requires a well-equipped laboratory with experienced personnel. The development of new diagnostic tools that are easy to use and adapted to the reality of affected populations and health systems is still a significant challenge. The main objective of this study was to measure Trypanosoma cruzi infection status using saliva samples of infected subjects. Blood and saliva samples from 20 T...
January 8, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29307228/prevalence-of-vitamin-d-deficiency-and-its-associated-factors-among-urban-elderly-population-in-hyderabad-metropolitan-city-south-india
#11
Palla Suryanarayana, Nimmathota Arlappa, Vadakattu Sai Santhosh, Nagalla Balakrishna, Pondey Lakshmi Rajkumar, Undrajavarapu Prasad, Banavath Bhoja Raju, Kommula Shivakeseva, Kondru Divya Shoshanni, Madabushi Seshacharyulu, Jagjeevan Babu Geddam, Prabhakaran Sobhana Prasanthi, Rajendran Ananthan
Background Deficiency of vitamin D has been associated with various health conditions. However, vitamin D deficiency (VDD) and factors associated with VDD are not well studied, especially in Indian urban elderly. Aim To assess the prevalence of VDD and its associated factors among the urban free-living elderly population in Hyderabad. Subjects and methods A community-based cross-sectional study was conducted among 298 urban elderly (≥60 years) by adapting a random sampling procedure. Demographic particulars were collected...
January 8, 2018: Annals of Human Biology
https://www.readbyqxmd.com/read/29304186/fixed-and-adaptive-beamforming-improves-speech-perception-in-noise-in-cochlear-implant-recipients-equipped-with-the-med-el-sonnet-audio-processor
#12
Clemens Honeder, Rudolfs Liepins, Christoph Arnoldner, Hana Šinkovec, Alexandra Kaider, Erich Vyskocil, Dominik Riss
OBJECTIVE: To determine the impact of the fixed and adaptive beamforming technology of the new MED-EL SONNET cochlear implant audio processor on speech perception in noise. METHODS: The study cohort comprises 18 postlingually deafened adult cochlear implant recipients with at least six months of experience. Speech reception thresholds were measured with the Oldenburg Sentence Test in continuous, speech-shaped noise. Target sentences were presented in front of the listener, with noise sources placed at -135° and 135°, respectively...
2018: PloS One
https://www.readbyqxmd.com/read/29299228/comparison-of-strategies-and-performance-of-functional-electrical-stimulation-cycling-in-spinal-cord-injury-pilots-for-competition-in-the-first-ever-cybathlon
#13
Christine Azevedo Coste, Vance Bergeron, Rik Berkelmans, Emerson Fachin Martins, Ché Fornusek, Arnin Jetsada, Kenneth J Hunt, Raymond Tong, Ronald Triolo, Peter Wolf
Functional Electrical Stimulation (FES) can elicit muscular contraction and restore motor function in paralyzed limbs. FES is a rehabilitation technique applied to various sensorimotor deficiencies and in different functional situations, e.g. grasping, walking, standing, transfer, cycling and rowing. FES can be combined with mechanical devices. FES-assisted cycling is mainly used in clinical environments for training sessions on cycle ergometers, but it has also been adapted for mobile devices, usually tricycles...
December 5, 2017: European Journal of Translational Myology
https://www.readbyqxmd.com/read/29289236/polyatomic-ions-from-a-high-current-ion-implanter-driven-by-a-liquid-metal-ion-source
#14
W Pilz, P Laufer, M Tajmar, R Böttger, L Bischoff
High current liquid metal ion sources are well known and found their first application as field emission electric propulsion thrusters in space technology. The aim of this work is the adaption of such kind of sources in broad ion beam technology. Surface patterning based on self-organized nano-structures on, e.g., semiconductor materials formed by heavy mono- or polyatomic ion irradiation from liquid metal (alloy) ion sources (LMAISs) is a very promising technique. LMAISs are nearly the only type of sources delivering polyatomic ions from about half of the periodic table elements...
December 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29286407/generic-protocol-for-optimization-of-heterologous-protein-production-using-automated-microbioreactor-technology
#15
Johannes Hemmerich, Lars Freier, Wolfgang Wiechert, Eric von Lieres, Marco Oldiges
A core business in industrial biotechnology using microbial production cell factories is the iterative process of strain engineering and optimization of bioprocess conditions. One important aspect is the improvement of cultivation medium to provide an optimal environment for microbial formation of the product of interest. It is well accepted that the media composition can dramatically influence overall bioprocess performance. Nutrition medium optimization is known to improve recombinant protein production with microbial systems and thus, this is a rewarding step in bioprocess development...
December 15, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29286320/fog-based-two-phase-event-monitoring-and-data-gathering-in-vehicular-sensor-networks
#16
Yongxuan Lai, Fan Yang, Jinsong Su, Qifeng Zhou, Tian Wang, Lu Zhang, Yifan Xu
Vehicular nodes are equipped with more and more sensing units, and a large amount of sensing data is generated. Recently, more and more research considers cooperative urban sensing as the heart of intelligent and green city traffic management. The key components of the platform will be a combination of a pervasive vehicular sensing system, as well as a central control and analysis system, where data-gathering is a fundamental component. However, the data-gathering and monitoring are also challenging issues in vehicular sensor networks because of the large amount of data and the dynamic nature of the network...
December 29, 2017: Sensors
https://www.readbyqxmd.com/read/29285419/developing-a-wireless-high-precision-and-processing-speed-pulse-monitoring-headset-using-photoplethysmography
#17
Yunhui Jiang, Jian Tang, Xiaoliang Wang, Chao Shen
In this paper, thorough improvement of pulse monitoring and analysis equipment with a headset structure is presented. In order to study the most suitable infrared wavelength for the acquisition of the pulse wave at the earlobe, Monte Carlo simulation was adapted. Both high frequency noise and baseline drift, generated in the signal acquisition process, are considered. To further optimize the system design and improve accuracy, for the sensor's dimensional drift, the corresponding compensation was carried on in the software...
2017: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/29284461/clinical-validation-and-assessment-of-a-modular-fluorescent-imaging-system-and-algorithm-for-rapid-detection-and-quantification-of-dental-plaque
#18
Keith Angelino, Pratik Shah, David A Edlund, Mrinal Mohit, Gregory Yauney
BACKGROUND: Significant numbers of adults and children have untreated plaque due to poor oral hygiene and consequently suffer from associate dental and systemic diseases. METHODS: A handheld device equipped with 405 nm light-emitting diodes was constructed to examine the prevalence of red fluorescence signatures associated with dental plaque. This device was used for in vivo imaging of all four incisors and all four canines of twenty-eight consenting human subjects...
December 28, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/29282212/musclemotion-a-versatile-open-software-tool-to-quantify-cardiomyocyte-and-cardiac-muscle-contraction-in-vitro-and-in-vivo
#19
Luca Sala, Berend J van Meer, Leon T Tertoolen, Jeroen Bakkers, Milena Bellin, Richard P Davis, Chris N Denning, Michel A Dieben, Thomas Eschenhagen, Elisa Giacomelli, Catarina Grandela, Arne Hansen, Eduard Holman, Monique R Jongbloed, Sarah M Kamel, Charlotte D Koopman, Quentin Lachaud, Ingra Mannhardt, Mervyn P Mol, Diogo Mosqueira, Valeria V Orlova, Robert Passier, Marcelo C Ribeiro, Umber Saleem, Godfrey Smith, Francis L L Burton, Christine L Mummery
Rationale: There are several methods to measure cardiomyocyte (CM) and muscle contraction but these require customized hardware, expensive apparatus and advanced informatics or can only be used in single experimental models. Consequently, data and techniques have been difficult to reproduce across models and laboratories, analysis is time consuming and only specialist researchers can quantify data. Objective: Here we describe and validate an automated, open source software tool (MUSCLEMOTION) adaptable for use with standard laboratory- and clinical imaging equipment that enables quantitative analysis of normal cardiac contraction, disease phenotypes and pharmacological responses...
December 27, 2017: Circulation Research
https://www.readbyqxmd.com/read/29280970/background-registration-based-adaptive-noise-filtering-of-lwir-mwir-imaging-sensors-for-uav-applications
#20
Byeong Hak Kim, Min Young Kim, You Seong Chae
Unmanned aerial vehicles (UAVs) are equipped with optical systems including an infrared (IR) camera such as electro-optical IR (EO/IR), target acquisition and designation sights (TADS), or forward looking IR (FLIR). However, images obtained from IR cameras are subject to noise such as dead pixels, lines, and fixed pattern noise. Nonuniformity correction (NUC) is a widely employed method to reduce noise in IR images, but it has limitations in removing noise that occurs during operation. Methods have been proposed to overcome the limitations of the NUC method, such as two-point correction (TPC) and scene-based NUC (SBNUC)...
December 27, 2017: Sensors
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