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https://www.readbyqxmd.com/read/28933778/synthesis-of-a-hycosul-peptide-substrate-library-to-dissect-protease-substrate-specificity
#1
Marcin Poreba, Guy S Salvesen, Marcin Drag
Many biologically and chemically based approaches have been developed to design highly active and selective protease substrates and probes. It is, however, difficult to find substrate sequences that are truly selective for any given protease, as different proteases can demonstrate a great deal of overlap in substrate specificities. In some cases, better enzyme selectivity can be achieved using peptide libraries containing unnatural amino acids such as the hybrid combinatorial substrate library (HyCoSuL), which uses both natural and unnatural amino acids...
October 2017: Nature Protocols
https://www.readbyqxmd.com/read/28930451/a-biomimetic-stress-sensitive-hydrogel-controlled-by-dna-nanoswitches
#2
Swapneel R Deshpande, Roel Hammink, Frank H T Nelissen, Alan E Rowan, Hans A Heus
One of the most intriguing and important aspects of biological supramolecular materials is its ability to adapt macroscopic properties in response to environmental cues for controlling cellular processes. Recently, bulk matrix stiffness, in particular stress sensitivity, has been established as a key mechanical cue in cellular function and development. However, stress-stiffening capacity and the ability to control and exploit this key characteristic is relatively new to the field of biomimetic materials. In this work, DNA-responsive hydrogels, composed of semiflexible PIC polymers equipped with DNA cross-linkers, were engineered to create mimics of natural biopolymer networks that capture these essential elastic properties and can be controlled by external stimuli...
September 20, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28915817/cultural-adaptation-of-a-pediatric-functional-assessment-for-rehabilitation-outcomes-research
#3
Kristen E Arestad, David MacPhee, Chun Y Lim, Mary A Khetani
BACKGROUND: Significant racial and ethnic health care disparities experienced by Hispanic children with special health care needs (CSHCN) create barriers to enacting culturally competent rehabilitation services. One way to minimize the impact of disparities in rehabilitation is to equip practitioners with culturally relevant functional assessments to accurately determine service needs. Current approaches to culturally adapting assessments have three major limitations: use of inconsistent translation processes; current processes assess for some, but not all, elements of cultural equivalence; and limited evidence to guide decision making about whether to undertake cultural adaptation with and without language translation...
September 15, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28912781/microrna-dynamic-regulators-of-macrophage-polarization-and-plasticity
#4
REVIEW
Jezrom Bokcaerin Self-Fordham, Afsar Raza Naqvi, Juhi Raju Uttamani, Varun Kulkarni, Salvador Nares
The ability of a healthy immune system to clear the plethora of antigens it encounters incessantly relies on the enormous plasticity displayed by the comprising cell types. Macrophages (MΦs) are crucial member of the mononuclear phagocyte system (MPS) that constantly patrol the peripheral tissues and are actively recruited to the sites of injury and infection. In tissues, infiltrating monocytes replenish MΦ. Under the guidance of the local micro-milieu, MΦ can be activated to acquire specialized functional phenotypes...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28910467/the-golden-hour-offset-surgical-treatment-team-operational-concept-experience-of-the-102nd-forward-surgical-team-in-operation-freedom-s-sentinel-2015-2016
#5
Jerry M Benavides, Linda C Benavides, Diane F Hale, Jonathan B Lundy
Theater Special Operations Force (SOF) medical planners have begun using Army Forward Surgical Teams (FSTs) to maintain a golden hour for U.S. SOF during Operation Freedom's Sentinel required adaptation in FST training, configuration, personnel, equipment, and employment to form Golden Hour Offset Surgical Treatment Teams (GHOST-Ts). This article describes one such FST's experience in Operation Freedom's Sentinel while deployed for 9 months in support of SOF in southern Afghanistan.
2017: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
https://www.readbyqxmd.com/read/28903474/nitric-oxide-heat-shock-protein-axis-in-menopausal-hot-flushes-neglected-metabolic-issues-of-chronic-inflammatory-diseases-associated-with-deranged-heat-shock-response
#6
Antônio Azambuja Miragem, Paulo Ivo Homem de Bittencourt
BACKGROUND: Although some unequivocal underlying mechanisms of menopausal hot flushes have been demonstrated in animal models, the paucity of similar approaches in humans impedes further mechanistic outcomes. Human studies might show some as yet unexpected physiological mechanisms of metabolic adaptation that permeate the phase of decreased oestrogen levels in both symptomatic and asymptomatic women. This is particularly relevant because both the severity and time span of hot flushes are associated with increased risk of chronic inflammatory disease...
September 1, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/28903001/open-source-assisted-laboratory-automation-through-graphical-user-interfaces-and-3d-printers-application-to-equipment-hyphenation-for-higher-order-data-generation
#7
Gabriel Germán Siano, Milagros Montemurro, Mirta Raquel Alcaráz, Hector Casimiro Goicoechea
In the current analytical chemistry, even though the modeling of higher-order data can result attractive, the generation of this kind of data implies some automation challenges, which are mainly related to the hidden programming languages and electronic details of the equipment. When techniques and/or equipment hyphenation is the key to obtain higher-order data, the required simultaneous control of them demands funds for new hardware, software and licenses, and also really skilled operators. In this work we present Design of Inputs-Outputs with Sikuli (D...
September 13, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28901134/diagnosis-of-tuberculosis-using-colorimetric-gold-nanoparticles-on-a-paper-based-analytical-device
#8
Tsung-Ting Tsai, Chia-Yu Huang, Chung-An Chen, Shu-Wei Shen, Mei-Chia Wang, Chao-Min Cheng, Chien-Fu Chen
We have developed a colorimetric sensing strategy employing gold nanoparticles and a paper-based analytical platform for the diagnosis of tuberculosis (TB). By utilizing the surface plasmon resonance effect, we were able to monitor changes in the color of a gold nanoparticle colloid based on the effects of single-stranded DNA probe molecules hybridizing with targeted double-stranded TB DNA. The hybridization event changes the surface charge density of the nanoparticles, causing them to aggregate to various degrees, which modifies the color of the solution in a manner that can be readily measured to determine the concentration of the targeted DNA analyte...
September 13, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28898740/transition-from-children-s-to-adult-services-for-young-adults-with-life-limiting-conditions-a-realist-review-of-the-literature
#9
REVIEW
Helen Kerr, Jayne Price, Honor Nicholl, Peter O'Halloran
BACKGROUND: Improvements in care and treatment have led to more young adults with life-limiting conditions living beyond childhood, which means they must make the transition from children's to adult services. This has proved a challenging process for both young adults and service providers, with complex transition interventions interacting in unpredictable ways with local contexts. OBJECTIVES: To explain how intervention processes interact with contextual factors to help transition from children's to adult services for young adults with life-limiting conditions...
June 23, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28895375/knowledge-attitudes-and-sun-safety-practices-among-agricultural-workers-in-the-autonomous-province-of-trento-north-eastern-italy-2016
#10
Matteo Riccò, Benedetta Razio, Leonardo Poletti, Claudio Panato
BACKGROUND: The purpose of this study was to determine evaluate sun safety knowledge, attitudes and practices (KAP) among agricultural workers (AWs) in the Autonomous Province of Trento (North-Eastern Italy). METHODS: A cross sectional study was performed among AWs who attended pesticide training courses (2016). Participants received a structured questionnaire focusing on KAP towards sun protective behaviours. Synthetic scores for knowledge (GKS), risk perception (RPS), behavioural adaptation and use of personal protective equipment (SPPS) were calculated...
September 8, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28889938/role-of-robotics-in-children-a-brave-new-world
#11
REVIEW
Anne-Françoise Spinoit, Hiep Nguyen, Ramnath Subramaniam
CONTEXT: The key in the evolution towards minimally invasive surgery is the availability of appropriate equipment, especially when procedures involve children. While robotic procedures in adults continue to struggle to prove measurable advantages compared with open or classical laparoscopic ones, the use of the robotic platform (RP) in pediatric urology is steadily increasing. OBJECTIVE: To review the contemporary literature regarding the use of robotic-assisted (RA) urologic interventions in children...
September 7, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28888607/effect-of-increasing-amounts-of-milk-replacer-powder-added-to-whole-milk-on-postweaning-performance-reproduction-glucose-metabolism-and-mammary-fat-pad-in-dairy-heifers
#12
C F A Lage, R A Azevedo, F S Machado, M M Campos, L G R Pereira, T R Tomich, B C Carvalho, B R C Alves, G B Santos, F Z Brandão, S G Coelho
The aim of this study was to evaluate the effects of increasing the total solids (TS) content of liquid feed, by adding increasing amounts of milk replacer powder to whole milk, on age at puberty and postweaning performance, glucose metabolism, and mammary fat pad of dairy heifers. Crossbreed Holstein × Gyr heifers (n = 58) were distributed into 4 different treatments during the preweaning period. Treatments consisted of liquid feeds with TS content of 12.5 (actual TS = 13.5 ± 0.53%; n = 15), 15.0 (actual TS = 16...
September 6, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28887132/structure-and-diversity-of-human-dendritic-spines-evidenced-by-a-new-three-dimensional-reconstruction-procedure-for-golgi-staining-and-light-microscopy
#13
Roman Reberger, Aline Dall'Oglio, Claudio R Jung, Alberto A Rasia-Filho
BACKGROUND: Different approaches aim to unravel detailed morphological features of neural cells. Dendritic spines are multifunctional units that reflect cellular connectivity, synaptic strength and plasticity. NEW METHOD: A novel three-dimensional (3D) reconstruction procedure is introduced for visualization of dendritic spines from human postmortem brain tissue using brightfield microscopy. The segmentation model was based on thresholding the intensity values of the dendrite spine image along 'z' stacks...
September 5, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28885378/radial-force-an-underestimated-parameter-in-oversizing-transcatheter-aortic-valve-replacement-prostheses-in-vitro-analysis-with-five-commercialized-valves
#14
Sandrine Egron, Buntaro Fujita, Lucía Gullón, Pott Désirée, Thomas Schmitz-Rode, Stephan Ensminger, Ulrich Steinseifer
The goal is to inform in depth on transcatheter aortic valve replacement (TAVR) prosthesis mechanical behavior, depending on frame type, design, and size, and how it crucially impacts the oversizing issue in clinical use, and ultimately the procedure outcome. Transcatheter aortic valve replacement is an established therapy for high-risk patients suffering from aortic stenosis, and the indication for TAVR is progressively expanding to intermediate-risk patients. Choosing the optimal oversizing degree is crucial to safely anchor the TAVR valve-which involves limiting the risks for embolism, aortic regurgitation, conductance disturbance, or annulus rupture-and to increase the valve prosthesis performance...
September 5, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28879312/regional-anesthesia-for-maxillofacial-surgery-in-developing-countries
#15
REVIEW
Soung Min Kim, Mi Hyun Seo, Hoon Myoung, Jong Ho Lee
Regional anesthesia in the maxillofacial region is safer and more efficient than general anesthesia when its indications are carefully considered. In addition, the majority of medical institutions in developing countries are not well equipped for proper anesthesia and elective surgery. In this review, we describe regional anesthesia and cutaneous nerve divisions in the maxillofacial region. In addition, we summarize detailed regional anesthetic techniques adapted for representative cleft lip cases in developing countries...
December 2016: J Dent Anesth Pain Med
https://www.readbyqxmd.com/read/28877675/signal-functions-for-emergency-obstetric-care-as-an-intervention-for-reducing-maternal-mortality-a-survey-of-public-and-private-health-facilities-in-lusaka-district-zambia
#16
Tannia Tembo, Gershom Chongwe, Bellington Vwalika, Lungowe Sitali
BACKGROUND: Zambia's maternal mortality ratio was estimated at 398/100,000 live births in 2014. Successful aversion of deaths is dependent on availability and usability of signal functions for emergency obstetric and neonatal care. Evidence of availability, usability and quality of signal functions in urban settings in Zambia is minimal as previous research has evaluated their distribution in rural settings. This survey evaluated the availability and usability of signal functions in private and public health facilities in Lusaka District of Zambia...
September 6, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28877351/evaluation-of-a-novel-collimator-for-molecular-breast-tomosynthesis
#17
David R Gilland, Benjamin L Welch, Seungjoon Lee, Brian Kross, Andrew G Weisenberger
PURPOSE: This study investigated a novel gamma camera for molecular breast tomosynthesis (MBT), which is a nuclear breast imaging method that uses limited angle tomography. The camera is equipped with a variable angle, slant-hole (VASH) collimator that allows the camera to remain close to the breast throughout the acquisition. The goal of this study was to evaluate the spatial resolution and count sensitivity of this camera and to compare contrast and contrast-to-noise ratio (CNR) with conventional planar imaging using an experimental breast phantom...
September 6, 2017: Medical Physics
https://www.readbyqxmd.com/read/28873961/transcriptome-analysis-of-the-response-of-burmese-python-to-digestion
#18
Jinjie Duan, Kristian Wejse Sanggaard, Leif Schauser, Sanne Enok Lauridsen, Jan J Enghild, Mikkel Heide Schierup, Tobias Wang
Exceptional and extreme feeding behaviour makes the Burmese python (Python bivittatus) an interesting model to study physiological remodelling and metabolic adaptation in response to refeeding after prolonged starvation. In this study, we used transcriptome sequencing of 5 visceral organs during fasting as well as 24 hours and 48 hours after ingestion of a large meal to unravel the postprandial changes in Burmese pythons. We first used the pooled data to perform a de novo assembly of the transcriptome and supplemented this with a proteomic survey of enzymes in the plasma and gastric fluid...
August 1, 2017: GigaScience
https://www.readbyqxmd.com/read/28868750/life-in-a-bubble-the-role-of-the-labyrinth-organ-in-determining-territory-mating-and-aggressive-behaviours-in-anabantoids
#19
REVIEW
M Tate, R E McGoran, C R White, S J Portugal
The anabantoids are a group of c. 137 species of air-breathing freshwater fishes found in Africa and southern Asia. All anabantoids have a pair of suprabranchial chambers that each house an air-breathing organ known as the labyrinth apparatus: a complex bony structure lined with thin, highly vascularised respiratory epithelium. The labyrinth apparatus allows anabantoids to extract oxygen from air and is a morpho-physiological innovation that has had a dramatic influence on the behaviour of these fishes. Air-breathing influences a wide range of anabantoid behaviours, including territorial displays, courtship and breeding and parental care and also equips these fishes to persist in hypoxic and polluted water...
September 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/28865841/assessment-selection-in-human-automation-interaction-studies-the%C3%A2-failure-gam-2-e-and-review-of-assessment-methods-for-highly-automated-driving
#20
Camilla Grane
Highly automated driving will change driver's behavioural patterns. Traditional methods used for assessing manual driving will only be applicable for the parts of human-automation interaction where the driver intervenes such as in hand-over and take-over situations. Therefore, driver behaviour assessment will need to adapt to the new driving scenarios. This paper aims at simplifying the process of selecting appropriate assessment methods. Thirty-five papers were reviewed to examine potential and relevant methods...
August 30, 2017: Applied Ergonomics
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