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https://www.readbyqxmd.com/read/28228841/an-update-on-the-management-of-breast-cancer-in-africa
#1
REVIEW
V Vanderpuye, S Grover, N Hammad, PoojaPrabhakar, H Simonds, F Olopade, D C Stefan
BACKGROUND: There is limited information about the challenges of cancer management and attempts at improving outcomes in Africa. Even though South and North Africa are better resourceds to tackle the burden of breast cancer, similar poor prognostic factors are common to all countries. The five-year overall Survival rate for breast cancer patients does not exceed 60% for any low and middle-income country (LMIC) in Africa. In spite of the gains achieved over the past decade, certain characteristics remain the same such as limited availability of breast conservation therapies, inadequate access to drugs, few oncology specialists and adherence to harmful socio-cultural practices...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28226442/adaptive-attention-driven-speech-enhancement-for-eeg-informed-hearing-prostheses
#2
Neetha Das, Simon Van Eyndhoven, Tom Francart, Alexander Bertrand, Neetha Das, Simon Van Eyndhoven, Tom Francart, Alexander Bertrand, Tom Francart, Neetha Das, Simon Van Eyndhoven, Alexander Bertrand
State-of-the-art hearing prostheses are equipped with acoustic noise reduction algorithms to improve speech intelligibility. Currently, one of the major challenges is to perform acoustic noise reduction in so-called cocktail party scenarios with multiple speakers, in particular because it is difficult-if not impossible-for the algorithm to determine which are the target speaker(s) that should be enhanced, and which speaker(s) should be treated as interfering sources. Recently, it has been shown that electroencephalography (EEG) can be used to perform auditory attention detection, i...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28220414/quantitative-analysis-of-ligand-induced-endocytosis-of-flagellin-sensing-2-using-automated-image-segmentation
#3
Michelle E Leslie, Antje Heese
Plants are equipped with a suite of plant pattern recognition receptors (PRRs) that must be properly trafficked to and from the plasma membrane (PM), which serves as the host-pathogen interface, for robust detection of invading pathogenic microbes. Recognition of bacterial flagellin, or the derived peptide flg22, is facilitated by the PM-localized PRR, FLAGELLIN SENSING 2 (FLS2). Upon flg22 binding, FLS2 is rapidly internalized from the PM into endosomal compartments and subsequently degraded. To understand better the integration of FLS2 endocytosis and signaling outputs, we developed methods for the quantitative analysis of FLS2 trafficking using freely available bioimage informatic tools...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28218374/the-spaire-technique-allows-sparing-of-the-piriformis-and-obturator-internus-in-a-modified-posterior-approach-to-the-hip
#4
Richard J Hanly, Sabrina Sokolowski, Andrew John Timperley
INTRODUCTION: The Sparing Piriformis and Internus, Repair Externus (SPAIRE) technique allows a muscle sparing mini-posterior approach to the hip. METHOD: We present in this article a description of an adaptation of the familiar posterior approach (PA) in which the only tendon released is obturator externus. Termed SPAIRE, this muscle sparing technique enables preservation of the piriformis tendon and conjoint insertion of obturator internus and the gemelli. The technical description allows for safe and reliable replication by any surgeon familiar with the posterior approach (PA) to the hip without reliance on additional equipment, and without compromising the ability to convert into a more extensile approach...
February 8, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28215962/two-colour-fluorescence-fluorimetric-analysis-for-direct-quantification-of-bacteria-and-its-application-in-monitoring-bacteria-growth-in-cellulose-degradation-systems
#5
Kwabena O Duedu, Christopher E French
Monitoring bacteria growth is an important technique required for many applications such as testing bacteria against compounds (e.g. drugs), evaluating bacteria composition in the environment (e.g. sewage and wastewater or food suspensions) and testing engineered bacteria for various functions (e.g. cellulose degradation). Traditionally, rapid estimation of bacterial growth is performed using spectrophotometric measurement at 600nm (OD600) but this estimation does not differentiate live and dead cells or other debris...
February 16, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28208656/primetime-for-learning-genes
#6
REVIEW
Joyce Keifer
Learning genes in mature neurons are uniquely suited to respond rapidly to specific environmental stimuli. Expression of individual learning genes, therefore, requires regulatory mechanisms that have the flexibility to respond with transcriptional activation or repression to select appropriate physiological and behavioral responses. Among the mechanisms that equip genes to respond adaptively are bivalent domains. These are specific histone modifications localized to gene promoters that are characteristic of both gene activation and repression, and have been studied primarily for developmental genes in embryonic stem cells...
February 11, 2017: Genes
https://www.readbyqxmd.com/read/28205017/equipping-future-doctors-incorporating-management-and-leadership-into-medical-curriculums-in-the-united-kingdom
#7
Aniket Sonsale, Reshma Bharamgoudar
Throughout their careers, doctors are likely to come across complex management and leadership scenarios that many would not have had prior training in. Expectations of doctors are rising and it is becoming increasingly necessary to be able to astutely handle a variety of situations. Medical curricula must reflect this change and adapt to include the teaching of key management and leadership skills. Despite budgeting pressures, the National Health Service continues to spend vast sums of money on external management consultants...
February 15, 2017: Perspectives on Medical Education
https://www.readbyqxmd.com/read/28182678/an-improved-cs-lssvm-algorithm-based-fault-pattern-recognition-of-ship-power-equipments
#8
Yifei Yang, Minjia Tan, Yuewei Dai
A ship power equipments' fault monitoring signal usually provides few samples and the data's feature is non-linear in practical situation. This paper adopts the method of the least squares support vector machine (LSSVM) to deal with the problem of fault pattern identification in the case of small sample data. Meanwhile, in order to avoid involving a local extremum and poor convergence precision which are induced by optimizing the kernel function parameter and penalty factor of LSSVM, an improved Cuckoo Search (CS) algorithm is proposed for the purpose of parameter optimization...
2017: PloS One
https://www.readbyqxmd.com/read/28179074/learning-communication-from-erroneous-video-based-examples-a-double-blind-randomised-controlled-trial
#9
Felix Michael Schmitz, Kai Philipp Schnabel, Daniel Stricker, Martin Rudolf Fischer, Sissel Guttormsen
OBJECTIVE: Appropriate training strategies are required to equip undergraduate healthcare students to benefit from communication training with simulated patients. This study examines the learning effects of different formats of video-based worked examples on initial communication skills. METHODS: First-year nursing students (N=36) were randomly assigned to one of two experimental groups (correct v. erroneous examples) or to the control group (no examples). All the groups were provided an identical introduction to learning materials on breaking bad news; the experimental groups also received a set of video-based worked examples...
January 31, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28177160/learning-new-sequential-stepping-patterns-requires-striatal-plasticity-during-the-earliest-phase-of-acquisition
#10
Toru Nakamura, Masatoshi Nagata, Takeshi Yagi, Ann M Graybiel, Tetsuo Yamamori, Takashi Kitsukawa
Animals including humans execute motor behavior to reach their goals. For this purpose, they must choose correct strategies according to environmental conditions and shape many parameters of their movements, including their serial order and timing. To investigate the neurobiology underlying such skills, we used a multi-sensor equipped, motor-driven running wheel with adjustable sequences of foothold pegs on which mice ran to obtain water reward. When the peg patterns changed from a familiar pattern to a new pattern, the mice had to learn and implement new locomotor strategies in order to receive reward...
February 8, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28166828/a-psychological-intervention-to-promote-acceptance-and-adherence-to-non-invasive-ventilation-in-people-with-chronic-obstructive-pulmonary-disease-study-protocol-of-a-randomised-controlled-trial
#11
Eleonora Volpato, Paolo Banfi, Francesco Pagnini
BACKGROUND: People with chronic obstructive pulmonary disease (COPD) sometimes experience anxiety, depression and comorbid cognitive deficits. Rather than being merely a consequence of symptom-related physical impairments these additional problems may be part of the clinical course of the condition. The relationship between the physical and psychological aspects of the condition is illustrated by the patterns of use of non-invasive ventilation (NIV); NIV is often rejected or used inappropriately, resulting in clinical deterioration and an increase in health care costs...
February 6, 2017: Trials
https://www.readbyqxmd.com/read/28131859/systems-biology-of-robustness-and-flexibility-lactobacillus-buchneri-a-show-case
#12
REVIEW
Stefan Heinl, Reingard Grabherr
Lactobacillus buchneri is a lactic acid bacterium that naturally inhabits very different ecological niches and plays an ambivalent role in many food and feed fermentation processes, where it can act as useful starter or as spoilage organism. Due to its vicinity to important biotechnological processes like silage making, ethanol production, baking, fermenting vegetables or brewing, L. buchneri was subject of extensive research and is now a quite well studied microorganism. Recently, next generation 'OMICS'-methods were applied to investigate L...
January 25, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28129168/efficient-hybrid-image-warping-for-high-frame-rate-stereoscopic
#13
Andre Schollmeyer, Simon Schneegans, Stephan Beck, Anthony Steed, Bernd Froehlich
Modern virtual reality simulations require a constant high-frame rate from the rendering engine. They may also require very low latency and stereo images. Previous rendering engines for virtual reality applications have exploited spatial and temporal coherence by using image-warping to re-use previous frames or to render a stereo pair at lower cost than running the full render pipeline twice. However these previous approaches have shown artifacts or have not scaled well with image size. We present a new image-warping algorithm that has several novel contributions: an adaptive grid generation algorithm for proxy geometry for image warping; a low-pass hole-filling algorithm to address un-occlusion; and support for transparent surfaces by efficiently ray casting transparent fragments stored in per-pixel linked lists of an A-Buffer...
January 25, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28128685/scar-remodeling-with-the-association-of-monopolar-capacitive-radiofrequency-electric-stimulation-and-negative-pressure
#14
Giovanni Nicoletti, Paola Perugini, Sara Bellino, Priscilla Capra, Alberto Malovini, Omar Jaber, Marco Tresoldi, Angela Faga
OBJECTIVE: A study was established to objectively assess the effects of low-intensity electromagnetic and electric stimulation plus negative pressure on mature scars. BACKGROUND: Radiofrequency plus negative pressure therapy demonstrated a favorable reorganization and regeneration of the collagen and elastic fibers and was proposed for the treatment of cellulitis and skin stretch marks. METHODS: Twenty-six mature scars in 20 Caucasian patients (15 females and 5 males) were enrolled in the study...
January 24, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28127895/a-robust-feeding-strategy-to-maintain-set-point-glucose-in-mammalian-fed-batch-cultures-when-input-parameters-have-a-large-error
#15
Viktor Konakovsky, Christoph Clemens, Markus Michael Müller, Jan Bechmann, Christoph Herwig
Industrial CHO cell cultures run under fed-batch conditions are required to be controlled in particular ranges of glucose, while glucose is constantly consumed and must be replenished by a feed. The most appropriate feeding rate is ideally stoichiometric and adaptive in nature to balance the dynamically changing rate of glucose consumption. However, high errors in biomass and glucose estimation as well as limited knowledge of the true metabolic state challenge the control strategy. In this contribution, we take these errors into account and simulate the output with uncertainty trajectories in silico in order to control glucose concentration...
January 27, 2017: Biotechnology Progress
https://www.readbyqxmd.com/read/28114107/generation-of-synthetic-ct-data-using-patient-specific-daily-mr-image-data-and-image-registration
#16
Kim Melanie Kraus, Oliver Jäkel, Nina I Niebuhr, Asja Pfaffenberger
To fully exploit the advantages of magnetic resonance imaging (MRI) for radiotherapy (RT) treatment planning, a method is required to overcome the problem of lacking electron density information. We aim to establish and evaluate a new method for computed tomography (CT) data generation based on MRI and image registration. The thereby generated CT data is used for dose accumulation. We developed a process flow based on an initial pair of rigidly co-registered CT and T2-weighted MR image representing the same anatomical situation...
February 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28113746/fast-realistic-mri-simulations-based-on-generalized-multi-pool-exchange-tissue-model
#17
Fang Liu, Julia V Velikina, Walter F Block, Richard Kijowski, Alexey A Samsonov
We present MRiLab, a new comprehensive simulator for large-scale realistic MRI simulations on a regular PC equipped with a modern graphical processing unit (GPU). MRiLab combines realistic tissue modeling with numerical virtualization of an MRI system and scanning experiment to enable assessment of a broad range of MRI approaches including advanced quantitative MRI methods inferring microstructure on a sub-voxel level. A flexible representation of tissue microstructure is achieved in MRiLab by employing the generalized tissue model with multiple exchanging water and macromolecular proton pools rather than a system of independent proton isochromats typically used in previous simulators...
February 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28113686/multimodal-estimation-of-distribution-algorithms
#18
Qiang Yang, Wei-Neng Chen, Yun Li, C L Philip Chen, Xiang-Min Xu, Jun Zhang
Taking the advantage of estimation of distribution algorithms (EDAs) in preserving high diversity, this paper proposes a multimodal EDA. Integrated with clustering strategies for crowding and speciation, two versions of this algorithm are developed, which operate at the niche level. Then these two algorithms are equipped with three distinctive techniques: 1) a dynamic cluster sizing strategy; 2) an alternative utilization of Gaussian and Cauchy distributions to generate offspring; and 3) an adaptive local search...
February 15, 2016: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28113664/pre-clinical-mri-guided-focused-ultrasound-a-review-of-systems-and-current-practices
#19
Nicholas Ellens, Ari Partanen
Effective pre-clinical research is a vital component in the development of MRI-guided focused ultrasound (MRgFUS) and its translation to clinic. In this review we seek to outline the challenges at hand for effective pre-clinical research, survey different solutions, and underline best practices. Furthermore, we summarize efforts to build and characterize dedicated pre-clinical MRgFUS equipment, including lab prototypes and available commercial products. Finally, we discuss constraints and considerations specific to using clinical MRgFUS equipment in preclinical research...
September 13, 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28101879/private-sector-involvement-in-times-of-armed-conflict-what-are-the-constraints-for-trading-medical-equipment
#20
Georg Schmidt
OBJECTIVE: Today, healthcare facilities are highly dependent on the private sector to keep their medical equipment functioning. Moreover, private sector involvement becomes particularly important for the supply of spare parts and consumables. However, in times of armed conflict, the capacity of the corporate world appears to be seriously hindered. Subsequently, this study researches the influence of armed conflict on the private medical equipment sector. DESIGN: This study follows a qualitative approach by conducting 19 interviews with representatives of the corporate world in an active conflict zone...
November 2016: Journal of Emergency Management: JEM
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