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https://www.readbyqxmd.com/read/29924598/an-ultrasensitive-diagnostic-biochip-based-on-biomimetic-periodic-nanostructure-assisted-rolling-circle-amplification
#1
Qian Yao, Yingqian Wang, Jie Wang, Shaomin Chen, Haoyang Liu, Zhuoran Jiang, Xiaoe Zhang, Song-Mei Liu, Quan Yuan, Xiang Zhou
Developing portable and sensitive devices for point of care (POC) detection of low abundance bioactive molecules is highly valuable in early diagnosis of disease. Herein, an ultrasensitive photonic crystal-assisted rolling circle amplification (PC-RCA) biochip was constructed and further applied to serum circulating microRNAs (miRNAs) detection. The biochip integrates the optical signal enhancement capability of biomimetic PC surface with the thousand-fold signal amplification feature of RCA. The biomimetic PC displayed periodic dielectric nanostructure and significantly enhanced the signal intensity of RCA reaction, leading to efficient improvement of detection sensitivity...
June 20, 2018: ACS Nano
https://www.readbyqxmd.com/read/29924386/successful-identification-of-anatomical-markers-and-placement-of-feeding-tubes-in-critically-ill-patients-via-camera-assisted-technology-with-real-time-video-guidance
#2
Paul E Wischmeyer, Michelle M McMoon, Nathan H Waldron, Elizabeth J Dye
BACKGROUND: Enteral feeding via feeding tube (FT) provides essential nutrition support to critically ill patients or those who cannot intake adequate nutrition via the oral route. Unfortunately, 1%-2% of FTs placed blindly at bedside enter the airway undetected (as confirmed by x-ray), where they could result in adverse events. Misplaced FTs can cause complications including pneumothorax, vocal cord injury, bronchopleural fistula, pneumonia, and death. X-ray is typically performed to confirm FT placement before feeding, but may delay nutrition intake, may not universally identify misplacement, and adds cost and radiation exposure...
June 20, 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29924078/use-of-an-in-home-body-weight-support-system-by-a-child-with-spina-bifida
#3
Elena Kokkoni, Samuel W Logan, Tracy Stoner, Terri Peffley, James C Galloway
PURPOSE: To examine the feasibility of a new open-area body weight support system (BWSS) to act as both an "assistive" and a "rehabilitative" device within the home. INTERVENTION: A 5-year-old boy with spina bifida used the BWSS during self-selected activities for 10 weeks. Feasibility, behavioral, and clinical assessments provided a quantification of his activity in and out of the BWSS. OUTCOMES: On average, the child used the device on 2...
July 2018: Pediatric Physical Therapy
https://www.readbyqxmd.com/read/29923410/high-voltage-assisted-mechanical-stabilization-of-single-molecule-junctions
#4
David Gelbwaser-Klimovsky, Alán Aspuru-Guzik, Michael Thoss, Uri Peskin
Resonant tunneling is an efficient mechanism for charge transport through nano-scale conductance junctions due to the relatively high currents involved. However, continuous charging and discharging cycles of the nano-conductor during resonant tunneling often lead to mechanical instability. The realization of efficient nano-scale electronic components therefore depends to a large extent on the ability to mechanically stabilize them during resonant transport. In this work, we focus on single molecule junctions, demonstrating that their mechanical stability during resonant transport can be increased by increasing the bias voltage...
June 20, 2018: Nano Letters
https://www.readbyqxmd.com/read/29922959/in-vivo-inspection-of-the-olfactory-epithelium-feasibility-of-robotized-optical-biopsy
#5
Cédric Girerd, Thomas Lihoreau, Kanty Rabenorosoa, Brahim Tamadazte, Mourad Benassarou, Laurent Tavernier, Lionel Pazart, Emmanuel Haffen, Nicolas Andreff, Pierre Renaud
Inspecting the olfactory cleft can be of high interest, as it is an open access to neurons, and thus an opportunity to collect in situ related data in a non-invasive way. Also, recent studies show a strong link between olfactory deficiency and neurodegenerative diseases such as Alzheimer and Parkinson diseases. However, no inspection of this area is possible today, as it is very difficult to access. Only robot-assisted interventions seem viable to provide the required dexterity. The feasibility of this approach is demonstrated in this article, which shows that the path complexity to the olfactory cleft can be managed with a concentric tube robot (CTR), a particular type of continuum robot...
June 19, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29922958/mri-robots-for-needle-based-interventions-systems-and-technology
#6
Reza Monfaredi, Kevin Cleary, Karun Sharma
Magnetic resonance imaging (MRI) provides high-quality soft-tissue images of anatomical structures and radiation free imaging. The research community has focused on establishing new workflows, developing new technology, and creating robotic devices to change an MRI room from a solely diagnostic room to an interventional suite, where diagnosis and intervention can both be done in the same room. Closed bore MRI scanners provide limited access for interventional procedures using intraoperative imaging. MRI robots could improve access and procedure accuracy...
June 19, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29922382/the-reliability-of-technical-and-tactical-tagging-analysis-conducted-by-a-semi-automatic-vts-in-soccer
#7
Marco Beato, Mikael Jamil, Gavin Devereux
The Video Tracking multiple cameras system (VTS) is a technology that records two-dimensional position data (x and y) at high sampling rates (over 25 Hz). The VTS is of great interest because it can record external load variables as well as collect technical and tactical parameters. Performance analysis is mainly focused on physical demands, yet less attention has been afforded to technical and tactical factors. Digital.Stadium® VTS is a performance analysis device widely used at national and international levels (i...
June 2018: Journal of Human Kinetics
https://www.readbyqxmd.com/read/29921985/high-molecular-weight-von-willebrand-factor-multimer-loss-and-bleeding-in-patients-with-short-term-mechanical-circulatory-support-devices-a-case-series
#8
Michael Goldfarb, Lawrence S Czer, Lee D Lam, Jaime Moriguchi, Francisco A Arabia, Oksana Volod
Acquired von Willebrand syndrome (VWS) due to loss of high-molecular-weight multimers (HMWMs) has been reported with longer term mechanical devices and is associated with mucosal bleeding, a primary hemostasis type of bleeding. However, little is known whether a similar defect occurs in patients with short-term mechanical circulatory support (STMCS) devices. We reviewed von Willebrand factor (VWF) profiles in patients with STMCS devices who underwent VWS workup from December 2015 to March 2017 at an academic quaternary care hospital...
June 2018: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/29921563/the-burden-of-a-remote-trial-in-a-nursing-home-setting-qualitative-study
#9
Susie Donnelly, Brenda Reginatto, Oisin Kearns, Marie Mc Carthy, Bill Byrom, Willie Muehlhausen, Brian Caulfield
BACKGROUND: Despite an aging population, older adults are typically underrecruited in clinical trials, often because of the perceived burden associated with participation, particularly travel associated with clinic visits. Conducting a clinical trial remotely presents an opportunity to leverage mobile and wearable technologies to bring the research to the patient. However, the burden associated with shifting clinical research to a remote site requires exploration. While a remote trial may reduce patient burden, the extent to which this shifts burden on the other stakeholders needs to be investigated...
June 19, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29921307/controller-and-battery-changes-due-to-technical-problems-related-to-the-hvad%C3%A2-left-ventricular-assist-device-a-single-center-experience
#10
Emil Najjar, Ann Hallberg Kristensen, Tonje Thorvaldsen, Laila Hubbert, Peter Svenarud, Magnus Dalén, Agneta Månsson Broberg, Lars H Lund
BACKGROUND: The use of left ventricular assist devices (LVADs) has increased in the last decade. Major complications have been well described, but there is no data on device alarms and actual or threatening malfunction which impair quality of life and may impair outcomes. This study describes the technical problems related to the use of the HVAD® left ventricular assist device in a single center. METHODS: We retrospectively reviewed device malfunctions and outcomes in 22 patients with HVAD® left ventricular assist device followed at Karolinska University Hospital between 2011 and 2016...
June 19, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29921278/the-unique-contribution-of-e-cigarettes-for-tobacco-harm-reduction-in-supporting-smoking-relapse-prevention
#11
Caitlin Notley, Emma Ward, Lynne Dawkins, Richard Holland
BACKGROUND: We have little understanding of how vapers use e-cigarettes beyond cessation. E-cigarettes may have a role to play in reducing the health-related harms of tobacco smoking, through not only assisting smoking cessation attempts but also supporting long-term abstinence from smoking. However, there are fears that vaping may lead to the 'renormalisation' of smoking type behaviours. This study aimed to explore patterns of use and reported experiences of vapers quitting smoking using an e-cigarette in relation to long-term smoking status (abstinence or relapse)...
June 20, 2018: Harm Reduction Journal
https://www.readbyqxmd.com/read/29921097/an-implantable-turbomechanical-cavopulmonary-assist-device-guarded-optimism-for-harnessing-the-river-to-do-upstream-work
#12
EDITORIAL
David P Bichell
No abstract text is available yet for this article.
July 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29920115/harnessing-vehicle-to-pedestrian-v2p-communication-technology-sending-traffic-warnings-to-texting-pedestrians
#13
Pooya Rahimian, Elizabeth E O'Neal, Shiwen Zhou, Jodie M Plumert, Joseph K Kearney
OBJECTIVE: We examined how sending mobile-device warnings to texting pedestrians when they initiate an unsafe road crossing influences their decisions and actions. BACKGROUND: Pedestrian texting has been identified as a key risk factor in pedestrian-vehicle collisions. Advances in sensing and communications technology offer the possibility of providing pedestrians with information about traffic conditions to assist them in safely crossing traffic-filled roadways...
June 1, 2018: Human Factors
https://www.readbyqxmd.com/read/29916988/understanding-the-correlation-between-dsa-complement-activation-and-antibody-mediated-rejection-in-heart-transplant-recipients
#14
Qiuheng Zhang, Michelle Hickey, Diana Drogalis-Kim, Ying Zheng, David Gjertson, Martin Cadeiras, Tam Khuu, Arnold S Baas, Eugene C Depasquale, Nancy J Halnon, Gregory Perens, Juan Alejos, Daniel Cruz, Nsair Ali, Richard Shemin, Murray Kwon, Michael C Fishbein, Abbas Ardehali, Mario Deng, Elaine F Reed
BACKGROUND: Donor specific HLA antibodies (DSA) are associated with increased rates of rejection and of graft failure in cardiac transplantation. The goal of this study was to determine the association of preformed and posttransplant development of newly detected DSA (ndDSA) with antibody mediated rejection (AMR) and characterize the clinical relevance of complement activating DSA in heart allograft recipients. METHODS: The study included 128 adult and 48 pediatric heart transplant patients transplanted between 2010 to 2013...
June 18, 2018: Transplantation
https://www.readbyqxmd.com/read/29916986/macroporous-dual-compartment-hydrogels-for-minimally-invasive-transplantation-of-primary-human-hepatocytes
#15
Nailah Seale, Suvasini Ramaswamy, Yu-Ru Shih, Inder Verma, Shyni Varghese
BACKGROUND: Given the shortage of available organs for whole or partial liver transplantation, hepatocyte cell transplantation has long been considered a potential strategy to treat patients suffering from various liver diseases. Some of the earliest approaches that attempted to deliver hepatocytes via portal vein or spleen achieved little success due to poor engraftment. More recent efforts include transplantation of cell sheets or thin hepatocyte laden synthetic hydrogels. However, these implants must remain sufficiently thin to ensure that nutrients can diffuse into the implant...
June 18, 2018: Transplantation
https://www.readbyqxmd.com/read/29916835/the-modern-cardiovascular-care-unit-the-cardiologist-managing-multiorgan-dysfunction
#16
Thomas Bochaton, Eric Bonnefoy-Cudraz, Nadia Aissaoui
PURPOSE OF REVIEW: Despite many advances in the management of critically ill patients, cardiogenic shock remains a challenge because it is associated with high mortality. Even if there is no universally accepted definition of cardiogenic shock, end-perfusion organ dysfunction is an obligatory and major criterion of its definition.Organ dysfunction is an indicator that cardiogenic shock is already at an advanced stage and is undergoing a rapid self-aggravating evolution. The aim of the review is to highlight the importance to diagnose and to manage the organ dysfunction occurring in the cardiogenic shock patients by providing the best literature published this year...
June 16, 2018: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/29916713/high-voltage-efficiency-inorganic-perovskite-solar-cells-in-a-wide-solution-processing-window
#17
Linxing Zhang, Bo Li, Jifeng Yuan, Mengru Wang, Ting Shen, Fei Huang, Wen Wen, Guozhong Cao, Jianjun Tian
Inorganic halide perovskites exhibit significant photovoltaic performance due to their structural stability and high open-circuit voltage ( Voc ). Herein, a general strategy of solution engineering has been implemented to enable a wide solution-processing window for high Voc (∼1.3 V) and power conversion efficiency (PCE, ∼12.5%). We introduce a nontoxic solvent of dimethyl sulfoxide (DMSO) and an assisted heating process in the fabrication of CsPbI2 Br (CPI2) to control the improved crystallization. A wide solution-processing window including a wide range of solvent components and solute concentrations has been realized...
June 20, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29916695/tio2-photoanode-assisted-direct-solar-energy-harvesting-and-storage-in-a-solar-powered-redox-cell-using-halides-as-active-materials
#18
Shun Zhang, Chen Chen, Yangen Zhou, Yumin Qian, Jing Ye, Shiyun Xiong, Yu Zhao, Xiaohong Zhang
The rapid deployment of renewable energy is resulting in significant energy security, climate change mitigation, and economic benefits. We demonstrate here the direct solar energy harvesting and storage in a rechargeable solar-powered redox cell, which can be charged solely by solar irradiation. The cell follows a conventional redox-flow cell design with one integrated TiO2 photoanode in the cathode side. Direct charging the cell by solar irradiation results in the conversion of solar energy in to chemical energy...
June 19, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29916597/preliminary-report-on-left-ventricular-assist-devices-are-patients-and-caregivers-psychosocial-needs-adequately-addressed
#19
Silvia Rossi Ferrario, Gianluigi Balestroni, Chiara Gattoni, Giovanna Omarini, Pierangela Omarini, Paola Cerutti, Massimo Pistono
OBJECTIVES: Patients implanted with a Left Ventricular Assist Device (LVAD) constitute a new population of chronic heart failure (HF) patients requiring continuous medical support and representing heavy costs - both direct and indirect - for the healthcare system. If there is consensus about the increased survival, the psychosocial outcomes, in terms of psychological wellbeing, behavioral and social functioning of both patients and caregivers, are still unclear. Overall, it is not clear if local health and social services are equipped to support them in their needs...
November 2017: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
https://www.readbyqxmd.com/read/29915791/spindle-cell-pseudotumor-mimicking-malignancy-in-an-immunocompetent-patient-with-a-left-ventricular-assist-device
#20
Zahava C Farkas, Lavneet Chawla, Shalom Frager, Edward Esses, Yasmin Yusuf, Brad Dworkin
Cytomegalovirus (CMV)-induced pseudotumors, or mass-like lesions in the colon, are a rare entity. We report a case of CMV-related spindle cell pseudotumor in an immunocompetent patient with a left ventricular assist device. This case highlights the importance of considering CMV-induced inflammatory pseudotumor when evaluating tumorous lesions in the colon, as well as the importance of appropriate diagnostic work-up, including proper biopsy technique and meticulous review of the pathology.
2018: ACG Case Reports Journal
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