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Abdominal obesity and lung function

Andrea Parraguez Arévalo, Francisco Rojas Navarro, Macarena Ruz Céspedes, Paul Medina González, Máximo Escobar Cabello, Rodrigo Muñoz Cofré
INTRODUCTION: Child and adolescent obesity is an epidemiological problem in developing countries. Its prevalence among preschoolers and schoolchildren is over 30%. It has been associated with a wide range of health complications, including rapid loss of lung function leading to changes in physiology and ventilatory mechanics. The objective of this study was to analyze the association between obesity and the increase in specific airway resistance (sRaw) in a sample of obese children and adolescents from the district of Talca...
April 1, 2018: Archivos Argentinos de Pediatría
Eun Kyung Choe, Hae Yeon Kang, Young Lee, Seung Ho Choi, Hee Joung Kim, Joo Sung Kim
Obesity, particularly abdominal obesity, might be related to decreased lung function. We aimed to investigate whether obesity indices are associated with forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) in asymptomatic non-smokers through a longitudinal cohort study. The clinical records of 1,145 subjects (428 males, mean age 52.3 years) who underwent a comprehensive health evaluation, including spirometry and abdominal fat computed tomography, at least twice between 2007 and 2014 were retrospectively reviewed and analysed...
2018: PloS One
Nao Sonoda, Akiko Morimoto, Yukako Tatsumi, Kei Asayama, Takayoshi Ohkubo, Satoshi Izawa, Yuko Ohno
BACKGROUND: To assess the impact of diabetes on restrictive and obstructive lung function impairment. METHODS: This 5-year prospective study included 7524 participants aged 40-69years without lung function impairment at baseline who underwent a comprehensive medical check-up between April 2008 and March 2009 at Saku Central Hospital. Diabetes was defined by fasting plasma glucose ≥7.0mmol/l (126mg/dl), HbA1c≥6.5% (48mmol/mol), or a history of diabetes, as determined by interviews conducted by the physicians...
December 28, 2017: Metabolism: Clinical and Experimental
H-J Kim, J-H Park, J-Y Min, K-B Min, Y-S Seo, J M Yun, H Kwon, J-I Kim, B Cho
BACKGROUND: Some studies have provided the possibility that adipose tissue may mediate air pollution-induced lung dysfunction. Studies using quantified fat mass data are needed to understand the biological mechanisms between adipocyte and air pollution in lung function. We aimed to investigate whether abdominal adiposity measured by computed tomography (CT) modifies the effects of air pollution on lung function in Korean men. METHODS: A total of 1876 men who visited one of two health checkup centers were recruited for this study...
August 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
Soo Kyoung Kim, Ji Cheol Bae, Jong-Ha Baek, Jae Hwan Jee, Kyu Yeon Hur, Moon-Kyu Lee, Jae Hyeon Kim
This study was conducted to investigate whether baseline lung function or change in lung function is associated with the development of metabolic syndrome (MS) in Koreans. We analyzed clinical and laboratory data from 3,768 Koreans aged 40-60 years who underwent medical check-ups over a six-year period between 2006 and 2012. We calculated the percent change in forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1) over the study period. We tested for an association between baseline lung function or lung function change during the follow-up period and the development of MS...
2017: PloS One
D Nowakowski, K Kliś, M Żurawiecka, A Dubrowski, I Wronka
The purpose of this study was to evaluate lung function in healthy young female university students and to seek the relation of lung function to socioeconomic and anthropometric indices. The methodology consisted of spirometry tests, anthropometric measures and a questionnaire conducted in November of 2015 among 152 female university students. At first, lung function was analyzed for any relationship with socioeconomic factors and smoking. The results of a multi-factor analysis of variance demonstrate significant differences in the FEV1/FVC ratio depending on the general socioeconomic status...
2017: Advances in Experimental Medicine and Biology
Mar Sorlí-Aguilar, Francisco Martín-Luján, Gemma Flores-Mateo, Cristina Jardí-Piñana, Estefania Aparicio-Llopis, Josep Basora-Gallisà, Rosa Solà-Alberich
BACKGROUND: The aim of this study was to assess the association of key adiposity markers with lung function in smokers without respiratory disease in a Mediterranean population. METHODS: We performed a cross-sectional study with baseline data from a representative sample of the ESPITAP study in Spain. Participants were 738 smokers (52.3% men) without respiratory disease, aged 35 to 70, selected from 12 primary health care centres. We assessed weight, height, body mass index (BMI), waist circumference (WC) and waist-to-height ratio (WHtR)...
December 9, 2016: BMC Pulmonary Medicine
Ana Paula Limongi Richardelli Veloso, Karla Garcez Cusmanich
Background: Obesity can affect the thorax, diaphragm, and alterations in respiratory function even if the lungs are within normality. The respiratory compliance is very reduced by the increase in fat mass. Aim: To evaluate the effect of the physical therapeutic respiratory exercises on the thoracoabdominal mobility of obese individuals in pre-bariatric surgery. Methods: Cross-sectional and descriptive study, which used the cirtometry (axillary, xiphoid and abdominal) to evaluate the mobility of 74 individuals, 27 men and 47 women, in pre-bariatric surgery, assisted by the team EMAD, after eight weeks of physiotherapy, following a protocol of exercises, reevaluating and compared the measures pre and post intervention...
2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
Amela Pasic, Fahrija Skokic, Fuad Pasic, Miroslav Ilic
AIM: Asthma and obesity represent one of the most crucial public and health problems of modern society that frequently begin in childhood and have some mutual elements of risk. Abdominal distribution of connective tissue is important determinant which brings to decrease of lungs function. Multiple influence of overweight on function of the lungs would clearly manifest over reduction of forced expiratory volume in the first second (FEV1) and forced vital capacity (FVC). METHOD: Examining was conducted at Pediatric Clinic of University Clinical Hospital Tuzla during the year 2013/2014...
June 2016: Medical Archives
Sofia Wilhelmsson, Monika Fagevik Olsén, Trude Staalesen, Anna Elander, Malin Nygren-Bonnier
BACKGROUND: Weight loss after obesity and pregnancy is associated with excess abdominal skin and weakness of the abdominal wall, which is assumed to cause low back pain and reduce lung function. Today, abdominoplasty is the only known method to treat excess skin, and plication is used to improve aesthetics and function alone or in addition to surgery. There is lack of evidence concerning the surgery's effect on trunk muscles, lung function, and physical function. The aim was to evaluate the effect on trunk muscle endurance, lung function and self-rated physical function after abdominoplasty with and without muscle plication...
June 2017: Journal of Plastic Surgery and Hand Surgery
Thiago Thomaz Mafort, Rogério Rufino, Cláudia Henrique Costa, Agnaldo José Lopes
Obesity is currently one of the major epidemics of this millennium and affects individuals throughout the world. It causes multiple systemic complications, some of which result in severe impairment of organs and tissues. These complications involve mechanical changes caused by the accumulation of adipose tissue and the numerous cytokines produced by adipocytes. Obesity also significantly interferes with respiratory function by decreasing lung volume, particularly the expiratory reserve volume and functional residual capacity...
2016: Multidisciplinary Respiratory Medicine
T Kiss, T Bluth, M Gama de Abreu
BACKGROUND: Recent studies show that intraoperative protective ventilation is able to reduce postoperative pulmonary complications (PPC). OBJECTIVES: This article provides an overview of the definition and ways to predict PPC. We present different factors that lead to ventilator-induced lung injury and explain the concepts of stress and strain as well as driving pressure. Different strategies of mechanical ventilation to avoid PPC are discussed in light of clinical evidence...
August 2016: Der Anaesthesist
Aline Dill Winck, João Paulo Heinzmann-Filho, Rafaela Borges Soares, Juliana Severo da Silva, Cristhiele Taís Woszezenki, Letiane Bueno Zanatta
OBJECTIVE: To assess the effects of obesity on lung volume and capacity in children and adolescents. DATA SOURCE: This is a systematic review, carried out in Pubmed, Lilacs, Scielo and PEDro databases, using the following Keywords: Plethysmography; Whole Body OR Lung Volume Measurements OR Total Lung Capacity OR Functional Residual Capacity OR Residual Volume AND Obesity. Observational studies or clinical trials that assessed the effects of obesity on lung volume and capacity in children and adolescents (0-18 years) without any other associated disease; in English; Portuguese and Spanish languages were selected...
December 2016: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
Ivan Curjuric, Medea Imboden, Pierre-Olivier Bridevaux, Margaret W Gerbase, Margot Haun, Dirk Keidel, Ashish Kumar, Marco Pons, Thierry Rochat, Tamara Schikowski, Christian Schindler, Arnold von Eckardstein, Florian Kronenberg, Nicole M Probst-Hensch
Lung function is an independent predictor of mortality and serves as an aging marker in never smokers. The protein sirtuin-1 of gene SIRT1 has profound anti-inflammatory effects and regulates metabolic pathways. Its suggested longevity effects on lower organisms remain poorly studied in humans. In 1132 never smokers of the population-based SAPALDIA cohort, we investigated associations between single nucleotide polymorphisms (SNPs; rs730821, rs10997868, rs10823116) of SIRT1 and aging-related lung function decline over 11 years in terms of change in forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), FEV1/FVC ratio, and forced expiratory flow between 25 and 75 % of FVC (FEF25-75) using multiple linear regression models...
June 2016: Age (2005-)
A V Capelo, V M da Fonseca, M V M Peixoto, S R de Carvalho, C M Azevedo, M I G Elsas, B Marques
UNLABELLED: Abdominal obesity is associated with a risk of cardiovascular diseases, metabolic syndrome and decreased lung function. However, it is not known whether asthma control is influenced by the accumulation of adipose tissue in the various abdominal compartments. OBJECTIVE: To determine associations among abdominal adiposity distribution, asthma control, lung function and cytokines in women. METHODS AND DESIGN: In this cross-sectional study of asthmatic women, data on demographic variables, comorbid conditions, disease history, anthropometric and spirometric measurements were collected...
September 2016: Revista Portuguesa de Pneumologia
Hyung Koo Kang, Hye Yun Park, Byeong-Ho Jeong, Won-Jung Koh, Seong Yong Lim
Impaired lung function is a risk factor for cardiovascular (CV) events. However, it has not been well established whether FVC reduction even within normal range is associated with cardiovascular disease (CVD) risk and whether reduced FVC is an independent relationship of CVD irrespective of metabolic syndrome. Thus, we aimed to explore the relationship between FVC and CV-event risk using the FRS beyond the presence of metabolic syndrome or abdominal obesity in a representative Korean population based on data from the nationwide Korea National Health and Nutrition Examination Survey (KNHANES IV)...
November 2015: Medicine (Baltimore)
Nikolaus Buchmann, Kristina Norman, Elisabeth Steinhagen-Thiessen, Ilja Demuth, Rahel Eckardt
BACKGROUND: Previous studies have indicated a relationship between type II diabetes (T2D), metabolic syndrome (MetS) and pulmonary function but the pathological mechanism responsible remains unclear. The aim of the current analysis within the Berlin Aging Study II (BASE-II) was to investigate the influence of abdominal obesity and muscle mass on pulmonary function in subjects with T2D and MetS. MATERIAL AND METHODS: A prebronchodilator pulmonary function test was carried out in 1369 subjects from the BASE-II (mean age 69 ± 4 years, 51...
July 2016: Zeitschrift Für Gerontologie und Geriatrie
Nikolaus Buchmann, Kristina Norman, Elisabeth Steinhagen-Thiessen, Ilja Demuth, Rahel Eckardt
BACKGROUND: Previous studies have indicated a relationship between type II diabetes (T2D), metabolic syndrome (MetS) and pulmonary function but the pathological mechanism responsible remains unclear. The aim of the current analysis within the Berlin Aging Study II (BASE-II) was to investigate the influence of abdominal obesity and muscle mass on pulmonary function in subjects with T2D and MetS. MATERIAL AND METHODS: A prebronchodilator pulmonary function test was carried out in 1369 subjects from the BASE-II (mean age 69 ± 4 years, 51...
October 27, 2015: Zeitschrift Für Gerontologie und Geriatrie
Andreas Güldner, Marcelo Gama de Abreu
Postoperative pulmonary complications add to higher mortality and morbidity. This risk could be lowered with intraoperative protective ventilation, especially with low tidal volumes. The application of PEEP and the use of recruitment maneuvers can enhance the lung function during surgery, but can also cause haemodynamic instability. In patients with open abdominal surgery and no lung damage or obesity, PEEP and recruitment maneuvers have no protective effect against postoperative pulmonary complications. It is still unclear, wether the use of intraoperative PEEP in other patient groups and during different surgery procedures is relevant for lung protection...
September 2015: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
Camille Meslin, Colette Desert, Isabelle Callebaut, Anis Djari, Christophe Klopp, Frédérique Pitel, Sophie Leroux, Pascal Martin, Pascal Froment, Edith Guilbert, Florence Gondret, Sandrine Lagarrigue, Philippe Monget
Free fatty acid receptors (FFAR) belong to a family of five G-protein coupled receptors that are involved in the regulation of lipid metabolism, so that their loss of function increases the risk of obesity. The aim of this study was to determine the expansion of genes encoding paralogs of FFAR2 in the chicken, considered as a model organism for developmental biology and biomedical research. By estimating the gene copy number using quantitative polymerase chain reaction, genomic DNA resequencing, and RNA sequencing data, we showed the existence of 23 ± 1...
May 2015: Genome Biology and Evolution
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