keyword
https://read.qxmd.com/read/36311012/editorial-regulation-of-synaptic-structure-and-function
#21
EDITORIAL
Zhiyong Shao, Yang Yang, Zhitao Hu
No abstract text is available yet for this article.
2022: Frontiers in Molecular Neuroscience
https://read.qxmd.com/read/36130499/a-natural-transdifferentiation-event-involving-mitosis-is-empowered-by-integrating-signaling-inputs-with-conserved-plasticity-factors
#22
JOURNAL ARTICLE
Claudia Riva, Martina Hajduskova, Christelle Gally, Shashi Kumar Suman, Arnaud Ahier, Sophie Jarriault
Transdifferentiation, or direct cell reprogramming, is the conversion of one fully differentiated cell type into another. Whether core mechanisms are shared between natural transdifferentiation events when occurring with or without cell division is unclear. We have previously characterized the Y-to-PDA natural transdifferentiation in Caenorhabditis elegans, which occurs without cell division and requires orthologs of vertebrate reprogramming factors. Here, we identify a rectal-to-GABAergic transdifferentiation and show that cell division is required but not sufficient for conversion...
September 20, 2022: Cell Reports
https://read.qxmd.com/read/36120363/beneficial-effect-of-xuebijing-against-pseudomonas-aeruginosa-infection-in-caenorhabditis-elegans
#23
JOURNAL ARTICLE
Le Zhang, Yuxing Wang, Chang Cao, Yike Zhu, Wei Huang, Yi Yang, Haibo Qiu, Songqiao Liu, Dayong Wang
In the clinical intensive care units (ICU), the traditional Chinese medicine (TCM) formulation of Xuebijing has been frequently used for treating sepsis. Nevertheless, the underlying pharmacological mechanisms of Xuebijing remain largely unclear. Caenorhabditis elegans is an important experimental host for bacterial infections. Using C. elegans as an animal model, we here examined the potential of Xuebijing treatment against bacterial infection and the underlying mechanisms. Xuebijing treatment could inhibit the reduction tendency of lifespan caused by Pseudomonas aeruginosa infection...
2022: Frontiers in Pharmacology
https://read.qxmd.com/read/36075376/alteration-in-wnt-signaling-mediates-induction-of-transgenerational-toxicity-of-polystyrene-nanoplastics-in-c-elegans
#24
JOURNAL ARTICLE
Ruoran Xu, Xin Hua, Qi Rui, Dayong Wang
Polystyrene nanoparticles (PS-NPs) have a potential toxicity on offspring after the exposure. However, the molecular basis for PS-NP in inducing transgenerational toxicity remains largely unknown. In this study, the role and the underlying mechanism of germline Wnt signaling in regulating transgenerational toxicity of PS-NPs were determined using an in vivo animal model of Caenorhabditis elegans. Exposure to PS-NP (1-100 μg/L) increased expression of Wnt ligand LIN-44 and decreased expression of Wnt receptor MIG-1...
September 5, 2022: NanoImpact
https://read.qxmd.com/read/35973126/carnosol-reduced-pathogenic-protein-aggregation-and-cognitive-impairment-in-neurodegenerative-diseases-models-via-improving-proteostasis-and-ameliorating-mitochondrial-disorders
#25
JOURNAL ARTICLE
Yun Chen, Qiao Qin, Wen Zhao, Danxia Luo, Yingyin Huang, Guo Liu, Yong Kuang, Yong Cao, Yunjiao Chen
Neurodegenerative diseases (NDs) such as Alzheimer's disease, Parkinson's disease, and Huntington's disease are incurable diseases with progressive loss of neural function and require urgent development of effective treatments. Carnosol (CL) reportedly has a pharmacological effect in the prevention of dementia. Nevertheless, the mechanisms of CL's neuroprotection are not entirely clear. The present study aimed to investigate the effects and mechanisms of CL-mediated neuroprotection through Caenorhabditis elegans models...
August 31, 2022: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/35929788/discovery-of-non-autonomous-modulators-of-activated-ras
#26
JOURNAL ARTICLE
Marcos Corchado-Sonera, Komal Rambani, Kristen Navarro, Raleigh Kladney, James Dowdle, Gustavo Leone, Helen M Chamberlin
Communication between mesodermal cells and epithelial cells is fundamental to normal animal development and is frequently disrupted in cancer. However, the genes and processes that mediate this communication are incompletely understood. To identify genes that mediate this communication and alter the proliferation of cells with an oncogenic Ras genotype, we carried out a tissue-specific genome-wide RNAi screen in C. elegans animals bearing a let-60(n1046gf) (RasG13E) allele. The screen identifies 24 genes that, when knocked down in adjacent mesodermal tissue, suppress the increased vulval epithelial cell proliferation defect associated with let-60(n1046gf)...
August 5, 2022: G3: Genes—Genomes—Genetics
https://read.qxmd.com/read/35748387/gut-neuroendocrine-signaling-regulates-synaptic-assembly-in-c-elegans
#27
JOURNAL ARTICLE
Yanjun Shi, Lu Qin, Mengting Wu, Junyu Zheng, Tao Xie, Zhiyong Shao
Synaptic connections are essential to build a functional brain. How synapses are formed during development is a fundamental question in neuroscience. Recent studies provided evidence that the gut plays an important role in neuronal development through processing signals derived from gut microbes or nutrients. Defects in gut-brain communication can lead to various neurological disorders. Although the roles of the gut in communicating signals from its internal environment to the brain are well known, it remains unclear whether the gut plays a genetically encoded role in neuronal development...
August 3, 2022: EMBO Reports
https://read.qxmd.com/read/35675782/protein-disulfide-isomerase-pdi-6-regulates-wnt-secretion-to-coordinate-inter-tissue-upr-mt-activation-and-lifespan-extension-in-c-elegans
#28
JOURNAL ARTICLE
Xinyu Li, Jiasheng Li, Di Zhu, Ning Zhang, Xusheng Hao, Wenfeng Zhang, Qian Zhang, Yangli Liu, Xueying Wu, Ye Tian
Coordination of inter-tissue stress signaling is essential for organismal fitness. Neuronal mitochondrial perturbations activate the mitochondrial unfolded-protein response (UPRmt ) in the intestine via the mitokine Wnt signaling in Caenorhabditis elegans. Here, we found that the protein disulfide isomerase PDI-6 coordinates inter-tissue UPRmt signaling via regulating the Wnt ligand EGL-20. PDI-6 is expressed in the endoplasmic reticulum (ER) and interacts with EGL-20 through disulfide bonds that are essential for EGL-20 stability and secretion...
June 7, 2022: Cell Reports
https://read.qxmd.com/read/35660370/pop-1-tcf-ref-2-zic-and-t-box-factors-regulate-the-development-of-anterior-cells-in-the-c-elegans-embryo
#29
JOURNAL ARTICLE
Jonathan D Rumley, Elicia A Preston, Dylan Cook, Felicia L Peng, Amanda L Zacharias, Lucy Wu, Ilona Jileaeva, John Isaac Murray
Patterning of the anterior-posterior axis is fundamental to animal development. The Wnt pathway plays a major role in this process by activating the expression of posterior genes in animals from worms to humans. This observation raises the question of whether the Wnt pathway or other regulators control the expression of the many anterior-expressed genes. We found that the expression of five anterior-specific genes in Caenorhabditis elegans embryos depends on the Wnt pathway effectors pop-1/TCF and sys-1/β-catenin...
September 2022: Developmental Biology
https://read.qxmd.com/read/35461833/cell-polarity-control-by-wnt-morphogens
#30
REVIEW
Chung-Kuan Chen, Chun-Liang Pan
Cell polarity is regulated by both intrinsic properties of the cell and extrinsic factors in the environment. Wnts are secreted glycoproteins in graded distribution, and they function as morphogens to instruct cell fate and as guidance cues to steer axon growth cone, respectively. Recent studies suggest that Wnts also instruct cell polarization in diverse contexts, by engaging cytoskeletal machineries or transcriptional mechanisms. Here we review the literature of cell polarity control by Wnt glycoproteins, with an emphasis on the nematode Caenorhabditis elegans, a multi-cellular organism in which the importance of polarity-inducing factors can be verified in vivo...
July 2022: Developmental Biology
https://read.qxmd.com/read/35119932/targeted-damid-in-c-elegans-reveals-a-direct-role-for-lin-22-and-nhr-25-in-antagonizing-the-epidermal-stem-cell-fate
#31
JOURNAL ARTICLE
Dimitris Katsanos, Michalis Barkoulas
Transcription factors are key players in gene networks controlling cell fate specification during development. In multicellular organisms, they display complex patterns of expression and binding to their targets, hence, tissue specificity is required in the characterization of transcription factor-target interactions. We introduce here targeted DamID (TaDa) as a method for tissue-specific transcription factor target identification in intact Caenorhabditis elegans animals. We use TaDa to recover targets in the epidermis for two factors, the HES1 homolog LIN-22, and the NR5A1/2 nuclear hormone receptor NHR-25...
February 4, 2022: Science Advances
https://read.qxmd.com/read/35100345/genetic-analysis-of-caenorhabditis-elegans-pry-1-axin-suppressors-identifies-genes-involved-in-reproductive-structure-development-stress-responses-and-aging
#32
JOURNAL ARTICLE
Avijit Mallick, Nikita Jhaveri, Jihae Jeon, Yvonne Chang, Krupali Shah, Hannah Hosein, Bhagwati P Gupta
The Axin family of scaffolding proteins regulates a wide array of developmental and post-developmental processes in eukaryotes. Studies in the nematode Caenorhabditis elegans have shown that the Axin homolog PRY-1 plays essential roles in multiple tissues. To understand the genetic network of pry-1, we focused on a set of genes that are differentially expressed in the pry-1-mutant transcriptome and are linked to reproductive structure development. Knocking down eight of the genes (spp-1, clsp-1, ard-1, rpn-7, cpz-1, his-7, cdk-1, and rnr-1) via RNA interference efficiently suppressed the multivulva phenotype of pry-1 mutants...
February 4, 2022: G3: Genes—Genomes—Genetics
https://read.qxmd.com/read/35076532/the-immunoglobulin-superfamily-members-syg-2-and-syg-1-regulate-neurite-development-in-c-elegans
#33
JOURNAL ARTICLE
Dana K Tucker, Chloe S Adams, Gauri Prasad, Brian D Ackley
Neurons form elaborate networks by guiding axons and dendrites to appropriate destinations. Neurites require information about the relative body axes during the initial projection from the cell body, and failure to receive or interpret those cues correctly can result in outgrowth errors. We identified a mutation in the Ig superfamily member syg-2 in a screen for animals with anterior/posterior (A/P) axon guidance defects. We found that syg-2 and its cognate Ig family member syg-1 appear to function in a linear genetic pathway to control the outgrowth of GABAergic axons...
January 9, 2022: Journal of Developmental Biology
https://read.qxmd.com/read/34986795/caenorhabditis-elegans-etr-1-celf-has-broad-effects-on-the-muscle-cell-transcriptome-including-genes-that-regulate-translation-and-neuroblast-migration
#34
JOURNAL ARTICLE
Matthew E Ochs, Rebecca M McWhirter, Robert L Unckless, David M Miller, Erik A Lundquist
Migration of neuroblasts and neurons from their birthplace is central to the formation of neural circuits and networks. ETR-1 is the Caenorhabditis elegans homolog of the CELF1 (CUGBP, ELAV-like family 1) RNA-processing factor involved in neuromuscular disorders. etr-1 regulates body wall muscle differentiation. Our previous work showed that etr-1 in muscle has a non-autonomous role in neuronal migration, suggesting that ETR-1 is involved in the production of a signal emanating from body wall muscle that controls neuroblast migration and that interacts with Wnt signaling...
January 6, 2022: BMC Genomics
https://read.qxmd.com/read/34950042/sempervirine-inhibits-proliferation-and-promotes-apoptosis-by-regulating-wnt-%C3%AE-catenin-pathway-in-human-hepatocellular-carcinoma
#35
JOURNAL ARTICLE
Rongcai Yue, Haiping Liu, Yaxin Huang, Jing Wang, Dongmei Shi, Yanping Su, Yufei Luo, Ping Cai, Guilin Jin, Changxi Yu
Gelsemium elegans ( G. elegans ) Benth., recognized as a toxic plant, has been used as traditional Chinese medicine for the treatment of neuropathic pain and cancer for many years. In the present study, we aim to obtain the anti-tumor effects of alkaloids of G. elegans and their active components in hepatocellular carcinoma (HCC) and the potential mechanism was also further investigated. We demonstrated that sempervirine induced HCC cells apoptosis and the apoptosis was associated with cell cycle arrest during the G1 phase, up-regulation of p53 and down-regulation of cyclin D1, cyclin B1 and CDK2...
2021: Frontiers in Pharmacology
https://read.qxmd.com/read/34706230/p5a-atpase-controls-er-translocation-of-wnt-in-neuronal-migration
#36
JOURNAL ARTICLE
Tingting Li, Xiaoyan Yang, Zhigang Feng, Wang Nie, Zhiyu Fang, Yan Zou
The Wnt family contains conserved secretory proteins required for developmental patterning and tissue homeostasis. However, how Wnt is targeted to the endoplasmic reticulum (ER) for processing and secretion remains poorly understood. Here, we report that CATP-8/P5A ATPase directs neuronal migration non-cell autonomously in Caenorhabditis elegans by regulating EGL-20/Wnt biogenesis. CATP-8 likely functions as a translocase to translocate nascent EGL-20/Wnt polypeptide into the ER by interacting with the highly hydrophobic core region of EGL-20 signal sequence...
October 26, 2021: Cell Reports
https://read.qxmd.com/read/34694534/resiniferatoxin-hampers-the-nocifensive-response-of-caenorhabditis-elegans-to-noxious-heat-and-pathway-analysis-revealed-that-the-wnt-signaling-pathway-is-involved
#37
JOURNAL ARTICLE
Jennifer Ben Salem, Bruno Nkambeu, Dina N Arvanitis, Francis Beaudry
Resiniferatoxin (RTX) is a metabolite extracted from Euphorbia resinifera. RTX is a potent capsaicin analog with specific biological activities resulting from its agonist activity with the transient receptor potential channel vanilloid subfamily member 1 (TRPV1). RTX has been examined as a pain reliever, and more recently, investigated for its ability to desensitize cardiac sensory fibers expressing TRPV1 to improve chronic heart failure (CHF) outcomes using validated animal models. Caenorhabditis elegans (C...
October 25, 2021: Neurochemical Research
https://read.qxmd.com/read/34604213/wnt-signaling-induces-asymmetric-dynamics-in-the-actomyosin-cortex-of-the-c-elegans-endomesodermal-precursor-cell
#38
JOURNAL ARTICLE
Francesca Caroti, Wim Thiels, Michiel Vanslambrouck, Rob Jelier
During asymmetrical division of the endomesodermal precursor cell EMS, a cortical flow arises, and the daughter cells, endodermal precursor E and mesodermal precursor MS, have an enduring difference in the levels of F-actin and non-muscular myosin. Ablation of the cell cortex suggests that these observed differences lead to differences in cortical tension. The higher F-actin and myosin levels in the MS daughter coincide with cell shape changes and relatively lower tension, indicating a soft, actively moving cell, whereas the lower signal in the E daughter cell is associated with higher tension and a more rigid, spherical shape...
2021: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/34429379/cdk14-promotes-axon-regeneration-by-regulating-the-noncanonical-wnt-signaling-pathway-in-a-kinase-independent-manner
#39
JOURNAL ARTICLE
Naoki Hisamoto, Yoshiki Sakai, Kohei Ohta, Tatsuhiro Shimizu, Chun Li, Hiroshi Hanafusa, Kunihiro Matsumoto
The postinjury regenerative capacity of neurons is known to be mediated by a complex interaction of intrinsic regenerative pathways and external cues. In Caenorhabditis elegans , the initiation of axon regeneration is regulated by the nonmuscle myosin light chain-4 (MLC-4) phosphorylation signaling pathway. In this study, we have identified svh-16 / cdk-14 , a mammalian CDK14 homolog, as a positive regulator of axon regeneration in motor neurons. We then isolated the CDK-14-binding protein MIG-5/Disheveled (Dsh) and found that EGL-20/Wnt and the MIG-1/Frizzled receptor (Fz) are required for efficient axon regeneration...
October 6, 2021: Journal of Neuroscience
https://read.qxmd.com/read/34388088/sustained-expression-of-unc-4-homeobox-gene-and-unc-37-groucho-in-postmitotic-neurons-specifies-the-spatial-organization-of-the-cholinergic-synapses-in-c-elegans
#40
JOURNAL ARTICLE
Mizuki Kurashina, Jane Wang, Jeffrey Lin, Kathy Kyungeun Lee, Arpun Johal, Kota Mizumoto
Neuronal cell fate determinants establish the identities of neurons by controlling gene expression to regulate neuronal morphology and synaptic connectivity. However, it is not understood if neuronal cell fate determinants have postmitotic functions in synapse pattern formation. Here we identify a novel role for UNC-4 homeobox protein and its corepressor UNC-37/Groucho, in tiled synaptic patterning of the cholinergic motor neurons in Caenorhabditis elegans . We show that unc-4 is not required during neurogenesis but is required in the postmitotic neurons for proper synapse patterning...
August 13, 2021: ELife
keyword
keyword
18015
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.