keyword
https://read.qxmd.com/read/38483903/blmp-1-is-a-critical-temporal-regulator-of-dietary-restriction-induced-response-in-caenorhabditis-elegans
#1
JOURNAL ARTICLE
Qingyuan Hu, Yunpeng Xu, Mengjiao Song, Yumin Dai, Adam Antebi, Yidong Shen
The extrinsic diet and the intrinsic developmental programs are intertwined. Although extensive research has been conducted on how nutrition regulates development, whether and how developmental programs control the timing of nutritional responses remain barely known. Here, we report that a developmental timing regulator, BLMP-1/BLIMP1, governs the temporal response to dietary restriction (DR). At the end of larval development, BLMP-1 is induced and interacts with DR-activated PHA-4/FOXA, a key transcription factor responding to the reduced nutrition...
March 12, 2024: Cell Reports
https://read.qxmd.com/read/37986999/mab-5-hox-regulates-the-q-neuroblast-transcriptome-including-cwn-1-wnt-to-mediate-posterior-migration-in-caenorhabditis-elegans
#2
Vitoria K Paolillo, Matthew E Ochs, Erik A Lundquist
Neurogenesis involves the precisely-coordinated action of genetic programs controlling large-scale neuronal fate specification down to terminal events of neuronal differentiation. The Q neuroblasts in C. elegans , QL on the left and QR on the right, divide, differentiate, and migrate in a similar pattern to produce three neurons each. However, QL on the left migrates posteriorly, and QR on the right migrates anteriorly. The MAB-5/Hox transcription factor is necessary and sufficient for posterior Q lineage migration, and is normally expressed only in the QL lineage...
November 11, 2023: bioRxiv
https://read.qxmd.com/read/37976926/cadmium-induced-reproductive-toxicity-combined-with-a-correlation-to-the-oogenesis-process-and-competing-endogenous-rna-networks-based-on-a-caenorhabditis-elegans-model
#3
JOURNAL ARTICLE
Zhi Qu, Limin Liu, Xiaoliang Wu, Peisen Guo, Zengli Yu, Peixi Wang, Yuzhen Song, Shanqing Zheng, Nan Liu
Accumulation of the heavy metal Cadmium (Cd) in the ovaries and placenta can affect the structure and function of these organs and induce female reproductive toxicity. This toxicity may be due to Cd's similarity to estrogen and its ability to disrupt endocrine systems. However, the exact molecular mechanism by which Cd causes reproductive toxicity at the transcriptome level remains poorly understood. Hence, this study aimed to observe Cd-induced reproductive damage at the gene level, scrutinize the repercussions of Cd exposure on oogenesis, and explicate the putative pathogenesis of Cd-induced oogenesis based on Caenorhabditis elegans (C...
November 15, 2023: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/37961109/distinct-members-of-the-c-elegans-cembio-reference-microbiota-exert-cryptic-virulence-and-infection-protection
#4
Xavier Gonzalez, Javier E Irazoqui
Microbiotas are complex microbial communities that colonize specific niches in the host and provide essential organismal functions that are important in health and disease. A key aspect is the ability of each distinct community member to promote or impair host health, alone or in the context of the community, in hosts with varied levels of immune competence. Understanding such interactions is limited by the complexity and experimental accessibility of current systems and models. Recently, a reference twelve-member microbiota for the model organism C...
November 5, 2023: bioRxiv
https://read.qxmd.com/read/37927912/-pry-1-interacts-with-bar-1-to-regulate-vit-2-expression-lipid-levels-and-lifespan-in-caenorhabditis-elegans-adults
#5
JOURNAL ARTICLE
Atreyee De, Bhagwati Gupta
The C. elegans Axin homolog, PRY-1 , is essential for multiple biological processes including vulval development, lipid metabolism, and lifespan maintenance. pry-1 mutants exhibit lower lipid contents and knockdowns of vit genes in pry-1 mutants can restore lipid levels, implicating vitellogenins' involvement in PRY-1 -mediated lipid homeostasis. As a component of the canonical WNT signal transduction pathway, PRY-1 inhibits the function of the β-catenin ortholog BAR-1 during vulval development and other developmental events...
2023: microPublication. Biology
https://read.qxmd.com/read/37873079/the-germline-coordinates-mitokine-signaling
#6
Koning Shen, Jenni Durieux, Cesar G Mena, Brant M Webster, C Kimberly Tsui, Hanlin Zhang, Lawrence Joe, Kristen Berendzen, Andrew Dillin
The ability of mitochondria to coordinate stress responses across tissues is critical for health. In C. elegans , neurons experiencing mitochondrial stress elicit an inter-tissue signaling pathway through the release of mitokine signals, such as serotonin or the WNT ligand EGL-20, which activate the mitochondrial unfolded protein response (UPR MT ) in the periphery to promote organismal health and lifespan. We find that germline mitochondria play a surprising role in neuron-to-peripheral UPR MT signaling. Specifically, we find that germline mitochondria signal downstream of neuronal mitokines, like WNT and serotonin, and upstream of lipid metabolic pathways in the periphery to regulate UPR MT activation...
October 4, 2023: bioRxiv
https://read.qxmd.com/read/37781584/wnt-signaling-and-contact-mediated-repulsion-shape-sensory-dendritic-fields
#7
Christopher P Tzeng, Kang Shen
UNLABELLED: The complete and non-redundant coverage of sensory tissues by neighboring neurons enables effective detection of stimuli in the environment. How the neurites of adjacent neurons establish their boundaries to achieve this completeness in coverage remains incompletely understood. Here, we use distinct fluorescent reporters to study two neighboring sensory neurons with complex dendritic arbors, FLP and PVD, in C. elegans . We quantify the sizes of their dendritic fields, and identify CWN-2/Wnt and LIN-17/Frizzled as a ligand and receptor that regulate the relative dendritic field sizes of these two neurons...
September 15, 2023: bioRxiv
https://read.qxmd.com/read/37721005/signaling-circuits-and-the-apical-extracellular-matrix-in-aging-connections-identified-in-the-nematode-caenorhabditis-elegans
#8
REVIEW
Hannah Reich, Cathy Savage-Dunn
Numerous conserved signaling pathways play critical roles in aging, including insulin, TGF-β, Wnt, and autophagy pathways. Some of these pathways also play prominent roles in the formation and maintenance of the extracellular matrix. The nematode Caenorhabditis elegans has been an enduringly productive system for the identification of conserved mechanisms of biological aging. Recent studies in C. elegans highlight the regulatory circuits between conserved signaling pathways and the extracellular matrix, revealing a bidirectional relationship between these factors and providing a platform to address how regulation of and by the extracellular matrix can impact lifespan and organismal health during aging...
September 18, 2023: American Journal of Physiology. Cell Physiology
https://read.qxmd.com/read/37503055/sys-1-beta-catenin-inheritance-and-regulation-by-wnt-signaling-during-asymmetric-cell-division
#9
Maria F Valdes Michel, Bryan T Phillips
Asymmetric cell division (ACD) allows daughter cells of a polarized mother to acquire different developmental fates. In C. elegans , the Wnt/β-catenin Asymmetry (WβA) pathway oversees many embryonic and larval ACDs; here, a Wnt gradient induces an asymmetric distribution of Wnt signaling components within the dividing mother cell. One terminal nuclear effector of the WβA pathway is the transcriptional activator SYS-1/β-catenin. SYS-1 is sequentially negatively regulated during ACD; first by centrosomal regulation and subsequent proteasomal degradation and second by asymmetric activity of the β-catenin "destruction complex" in one of the two daughter cells, which decreases SYS-1 levels in the absence of WβA signaling...
July 21, 2023: bioRxiv
https://read.qxmd.com/read/37463652/baicalein-mitigates-oxidative-stress-and-enhances-lifespan-through-modulation-of-wnt-ligands-and-gata-factor-elt-3-in-caenorhabditis-elegans
#10
JOURNAL ARTICLE
Saswat Kumar Mohanty, Kitlangki Suchiang
AIMS: Age predispose individual to major diseases, and the biological processes contributing to aging are currently under intense investigation. Hence, plant-based natural compounds could be a potential target to counteract aging and age-associated diseases. So, the present study aims to investigate the antiaging properties of a natural compound Baicalein (BAI) on C. elegans and to elucidate the pathways or signaling molecules involved. METHODS: Herein, we investigated the inhibitory effects of BAI on different Wnt ligands of C...
September 15, 2023: Life Sciences
https://read.qxmd.com/read/37408272/-lactiplantibacillus-plantarum-lac16-attenuates-enterohemorrhagic-escherichia-coli-o157-h7-infection-by-inhibiting-virulence-traits-and-improving-intestinal-epithelial-barrier-function
#11
JOURNAL ARTICLE
Baikui Wang, Yuanhao Zhou, Qi Wang, Shujie Xu, Fei Wang, Min Yue, Zhonghua Zeng, Weifen Li
Large-scale use of antimicrobials in agriculture and medicine contributes to antibiotic residues in raw foods, the spread of antimicrobial resistance (AMR) and drug pollution, which seriously threatens human health and imposes significant economic burdens on society, suggesting the need for novel therapeutic options that prevent or control zoonoses. In this study, four probiotics were selected to assess their capability to alleviate pathogen-induced damage. Results showed that a simulated gastrointestinal juice and bile tolerated L...
May 21, 2023: Cells
https://read.qxmd.com/read/37326982/cell-shape-characterization-alignment-and-comparison-using-flowshape
#12
JOURNAL ARTICLE
Casper van Bavel, Wim Thiels, Rob Jelier
MOTIVATION: The shape of a cell is tightly controlled, and reflects important processes including actomyosin activity, adhesion properties, cell differentiation and polarization. Hence, it is informative to link cell shape to genetic and other perturbations. However, most currently used cell shape descriptors capture only simple geometric features such as volume and sphericity. We propose FlowShape, a new framework to study cell shapes in a complete and generic way. RESULTS: In our framework a cell shape is represented by measuring the curvature of the shape and mapping it onto a sphere in a conformal manner...
June 16, 2023: Bioinformatics
https://read.qxmd.com/read/37205471/long-distance-wnt-transport-in-axons-highlights-cell-type-specific-modes-of-wnt-transport-in-vivo
#13
Ariel M Pani, Michelle Favichia, Bob Goldstein
Wnt signaling performs critical functions in development, homeostasis, and disease states. Wnt ligands are secreted signaling proteins that often move between cells to activate signaling across a range of distances and concentrations. In different animals and developmental contexts, Wnts utilize distinct mechanisms for intercellular transport including diffusion, cytonemes and exosomes [1]. Mechanisms for intercellular Wnt dispersal remain controversial in part due to technical challenges with visualizing endogenous Wnt proteins in vivo , which has limited our understanding of Wnt transport dynamics...
May 3, 2023: bioRxiv
https://read.qxmd.com/read/37184061/precise-temporal-control-of-neuroblast-migration-through-combined-regulation-and-feedback-of-a-wnt-receptor
#14
JOURNAL ARTICLE
Erik S Schild, Shivam Gupta, Clément Dubois, Euclides E Fernandes Póvoa, Marie-Anne Félix, Andrew Mugler, Hendrik C Korswagen
Many developmental processes depend on precise temporal control of gene expression. We have previously established a theoretical framework for regulatory strategies that can govern such high temporal precision, but experimental validation of these predictions was still lacking. Here, we use the time-dependent expression of a Wnt receptor that controls neuroblast migration in C. elegans as a tractable system to study a robust, cell-intrinsic timing mechanism in vivo. Single molecule mRNA quantification showed that the expression of the receptor increases non-linearly, a dynamic that is predicted to enhance timing precision over an unregulated, linear increase in timekeeper abundance...
May 15, 2023: ELife
https://read.qxmd.com/read/36839265/naringin-alleviates-glucose-induced-aging-by-reducing-fat-accumulation-and-promoting-autophagy-in-caenorhabditis-elegans
#15
JOURNAL ARTICLE
Peisen Guo, Panpan Wang, Limin Liu, Peixi Wang, Guimiao Lin, Zhi Qu, Zengli Yu, Nan Liu
Naringin (Nar) is a dihydroflavonoid compound, widely found in citrus fruit and used in Chinese herbal medicine. As a phytochemical, it acts as a dietary supplement that can delay aging and prevent aging-related disease, such as obesity and diabetes. However, its exact mechanism remains unclear. In this study, the high-glucose-induced (HGI) Caenorhabditis elegans model was used to evaluate the anti-aging and anti-obesity effects of Nar. The mean lifespan and fast movement span of HGI worms were extended roughly 24% and 11%, respectively, by Nar treatment...
February 10, 2023: Nutrients
https://read.qxmd.com/read/36766695/the-rosetta-stone-hypothesis-based-interaction-of-the-tumor-suppressor-proteins-nit1-and-fhit
#16
JOURNAL ARTICLE
Sonnhild Mittag, Franziska Wetzel, Sebastian Y Müller, Otmar Huber
In previous studies, we have identified the tumor suppressor proteins Fhit (fragile histidine triad) and Nit1 (Nitrilase1) as interaction partners of β-catenin both acting as repressors of the canonical Wnt pathway. Interestingly, in D. melanogaster and C. elegans these proteins are expressed as NitFhit fusion proteins. According to the Rosetta Stone hypothesis, if proteins are expressed as fusion proteins in one organism and as single proteins in others, the latter should interact physically and show common signaling function...
January 17, 2023: Cells
https://read.qxmd.com/read/36737562/antinociceptive-activity-of-vanilloids-in-caenorhabditis-elegans-is-mediated-by-the-desensitization-of-the-trpv-channel-ocr-2-and-specific-signal-transduction-pathways
#17
JOURNAL ARTICLE
Bruno Nkambeu, Jennifer Ben Salem, Francis Beaudry
Vanilloids, including capsaicin and eugenol, are ligands of transient receptor potential channel vanilloid subfamily member 1 (TRPV1). Prolonged treatment with vanilloids triggered the desensitization of TRPV1, leading to analgesic or antinociceptive effects. Caenorhabditis elegans (C. elegans) is a model organism expressing vanilloid receptor orthologs (e.g., OSM-9 and OCR-2) that are associated with behavioral and physiological processes, including sensory transduction. We have shown that capsaicin and eugenol hamper the nocifensive response to noxious heat in C...
February 3, 2023: Neurochemical Research
https://read.qxmd.com/read/36449574/insulin-igf-dependent-wnt-signaling-promotes-formation-of-germline-tumors-and-other-developmental-abnormalities-following-early-life-starvation-in-caenorhabditis-elegans
#18
JOURNAL ARTICLE
Nathan C Shaul, James M Jordan, Ivan B Falsztyn, L Ryan Baugh
The Developmental Origins of Health and Disease (DOHaD) hypothesis postulates that early-life stressors can predispose people to disease later in life. In the roundworm Caenorhabditis elegans, prolonged early-life starvation causes germline tumors, uterine masses and other gonad abnormalities to develop in well-fed adults. Reduction of insulin/insulin-like growth factor (IGF) signaling (IIS) during larval development suppresses these starvation-induced abnormalities. However, molecular mechanisms at play in formation and suppression of starvation-induced abnormalities are unclear...
November 30, 2022: Genetics
https://read.qxmd.com/read/36378164/channel-independent-function-of-unc-9-innexin-in-spatial-arrangement-of-gabaergic-synapses-in-c-elegans
#19
JOURNAL ARTICLE
Ardalan Hendi, Long-Gang Niu, Andrew William Snow, Richard Ikegami, Zhao-Wen Wang, Kota Mizumoto
Precise synaptic connection of neurons with their targets is essential for the proper functioning of the nervous system. A plethora of signaling pathways act in concert to mediate the precise spatial arrangement of synaptic connections. Here we show a novel role for a gap junction protein in controlling tiled synaptic arrangement in the GABAergic motor neurons in Caenorhabditis elegans , in which their axons and synapses overlap minimally with their neighboring neurons within the same class. We found that while EGL-20/Wnt controls axonal tiling, their presynaptic tiling is mediated by a gap junction protein UNC-9/Innexin, that is localized at the presynaptic tiling border between neighboring dorsal D-type GABAergic motor neurons...
November 15, 2022: ELife
https://read.qxmd.com/read/36323254/cholinergic-receptor-wnt-pathway-controls-immune-activation-by-sensing-intestinal-dysfunction
#20
JOURNAL ARTICLE
Jie Ren, Yu Sang, Alejandro Aballay
Alterations in the intestinal physiology caused by pathogen colonization result in immune activation. To provide insights into the mechanisms underlying the control of immune activation by changes in intestinal homeostasis, we conducted a forward genetic screen for suppressors of immune activation by intestinal distension in Caenorhabditis elegans. Our results indicate that C. elegans ACC-4, a member of a family of acetylcholine receptors, is required in immune activation by defects in the defecation motor program or by pathogen infection...
November 1, 2022: Cell Reports
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