Pierre Recouvreux, Pritha Pai, Valentin Dunsing, Rémy Torro, Monika Ludanyi, Pauline Mélénec, Mariem Boughzala, Vincent Bertrand, Pierre-François Lenne
Different signaling mechanisms concur to ensure robust tissue patterning and cell fate instruction during animal development. Most of these mechanisms rely on signaling proteins that are produced, transported, and detected. The spatiotemporal dynamics of signaling molecules are largely unknown, yet they determine signal activity's spatial range and time frame. Here, we use the Caenorhabditis elegans embryo to study how Wnt ligands, an evolutionarily conserved family of signaling proteins, dynamically organize to establish cell polarity in a developing tissue...
April 5, 2024: Current Biology: CB