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Non-alcoholic fat liver

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https://www.readbyqxmd.com/read/28647361/apolipoprotein-o-expression-in-mouse-liver-enhances-hepatic-lipid-accumulation-by-impairing-mitochondrial-function
#1
Feng Tian, Chen-Lu Wu, Bi-Lian Yu, Ling Liu, Jia-Rui Hu
Apolipoprotein O (ApoO) was recently observed in the cellular mitochondrial inner membrane, which plays a role in mitochondrial function and is associated with myocardiopathy. Empirical information on the physiological functions of apoO is therefore limited. In this study, we aimed to elucidate the effect of apoO on hepatic fatty acid metabolism. An adenoviral vector expressing hApoO was constructed and introduced into chow diet and high-fat diet induced mice and the L02 human hepatoma cell line. High levels of hApoO mRNA and protein were detected in the liver, and the expression of lipid metabolism genes was significantly altered compared with negative controls...
June 21, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28647291/genistein-supplementation-improves-insulin-resistance-and-inflammatory-state-in-non-alcoholic-fatty-liver-patients-a-randomized-controlled-trial
#2
Sasan Amanat, Mohammad Hassan Eftekhari, Mohammad Fararouei, Kamran Bagheri Lankarani, Seyed Jalil Massoumi
BACKGROUND & AIMS: The beneficial effect of genistein has indicated on metabolic disorders and inflammatory state. The aim of this study was to investigate the effect of genistein supplementation on non-alcoholic fatty liver disease (NAFLD) as the hepatic manifest of metabolic syndrome. METHODS: In the present randomized double-blind controlled trial, patients with NAFLD were daily supplemented with either 250 mg genistein (n = 41) or placebo (n = 41) for 8-weeks...
June 1, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28646856/the-imbalance-of-th17-treg-cells-is-involved-in-the-progression-of-nonalcoholic-fatty-liver-disease-in-mice
#3
Beihui He, Liyan Wu, Wei Xie, Yitong Shao, Jianping Jiang, Zhenzhong Zhao, Maoxiang Yan, Zhiyun Chen, Dawei Cui
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a common, chronic liver disease worldwide. Recent studies have shown that T helper (Th) 17 and regulatory T (Treg) cells play critical roles in various disorders of liver inflammation. Here, we explored the value of polyene phosphatidylcholine capsules (PPC) for regulating the imbalance of Th17/Treg cells in the pathogenesis of mice with NAFLD. METHODS: C57BL/6 mice were randomly divided into three groups as follows:normal diet (ND), high-fat diet (HF),and HF plus PPC(HF + PPC)...
June 24, 2017: BMC Immunology
https://www.readbyqxmd.com/read/28645738/human-germline-hedgehog-pathway-mutations-predispose-to-fatty-liver
#4
Maria J Guillen Sacoto, Ariel F Martinez, Yu Abe, Paul Kruszka, Karin Weiss, Joshua L Everson, Ramon Bataller, David E Kleiner, Jerrold M Ward, Kathleen K Sulik, Robert J Lipinski, Benjamin D Solomon, Maximilian Muenke
BACKGROUND & AIMS: Non-alcoholic fatty liver disease (NAFLD) is the most common form of liver disease. Activation of hedgehog (Hh) signaling has been implicated in the progression of NAFLD and proposed as a therapeutic target; however, the effects of Hh signaling inhibition have not been studied in humans with germline mutations affecting this pathway. METHODS: Patients with holoprosencephaly (HPE), a disorder associated with germline mutations disrupting Sonic hedgehog (SHH) signaling, were clinically evaluated for NAFLD...
June 20, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28643888/combination-of-citrus-polymethoxyflavones-green-tea-polyphenols-and-lychee-extracts-suppresses-obesity-and-hepatic-steatosis-in-high-fat-diet-induced-obese-mice
#5
Min-Hsiung Pan, Guliang Yang, Shiming Li, Ming-Yi Li, Mei-Ling Tsai, Jia-Ching Wu, Vladimir Badmaev, Chi-Tang Ho, Ching-Shu Lai
SCOPE: SlimTrym(®) is a formulated product composed of citrus polymethoxyflavones (PMFs), green tea extract and lychee extract. We investigated the effect of dietary SlimTrym(®) on diet-induced obesity and associated non-alcoholic fatty liver disease (NAFLD) in mice. METHODS AND RESULTS: Male C57BL/6 mice were fed a normal diet (ND), high fat diet (HFD) or HFD containing 0.1% or 0.5% SlimTrym(®) for sixteen weeks. Dietary SlimTrym(®) significantly reduced weight gain and relative perigonadal, retroperitoneal, mesenteric fat weight as well as the size of adipocyte in HFD-fed mice...
June 23, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28640216/a-branched-chain-amino-acid-related-metabolic-signature-characterizes-obese-adolescents-with-non-alcoholic-fatty-liver-disease
#6
Martina Goffredo, Nicola Santoro, Domenico Tricò, Cosimo Giannini, Ebe D'Adamo, Hongyu Zhao, Gang Peng, Xiaoqing Yu, Tukiet T Lam, Bridget Pierpont, Sonia Caprio, Raimund I Herzog
Dysregulation of several metabolite pathways, including branched-chain amino acids (BCAAs), are associated with Non-Alcoholic Fatty Liver Disease (NAFLD) and insulin resistance in adults, while studies in youth reported conflicting results. We explored whether, independently of obesity and insulin resistance, obese adolescents with NAFLD display a metabolomic signature consistent with disturbances in amino acid and lipid metabolism. A total of 180 plasma metabolites were measured by a targeted metabolomic approach in 78 obese adolescents with (n = 30) or without (n = 48) NAFLD assessed by magnetic resonance imaging (MRI)...
June 22, 2017: Nutrients
https://www.readbyqxmd.com/read/28638220/green-tea-polyphenols-ameliorate-non-alcoholic-fatty-liver-disease-through-upregulating-ampk-activation-in-high-fat-fed-zucker-fatty-rats
#7
Yi Tan, Jane Kim, Jing Cheng, Madeleine Ong, Wei-Guo Lao, Xing-Liang Jin, Yi-Guang Lin, Linda Xiao, Xue-Qiong Zhu, Xian-Qin Qu
AIM: To investigate protective effects and molecular mechanisms of green tea polyphenols (GTP) on non-alcoholic fatty liver disease (NAFLD) in Zucker fatty (ZF) rats. METHODS: Male ZF rats were fed a high-fat diet (HFD) for 2 wk then treated with GTP (200 mg/kg) or saline (5 mL/kg) for 8 wk, with Zucker lean rat as their control. At the end of experiment, serum and liver tissue were collected for measurement of metabolic parameters, alanine aminotransferase (ALT) and aspartate aminotransferase (AST), inflammatory cytokines and hepatic triglyceride and liver histology...
June 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28637408/lifestyle-modifications-in-non-alcoholic-fatty-liver-disease-and-non-alcoholic-steatohepatitis
#8
Konstantinos Stavropoulos, Konstantinos Imprialos, Andreas Pittaras, Charles Faselis, Puneet Narayan, Peter Kokkinos
Non-alcoholic fatty liver disease (NAFLD) is one of the most common diseases worldwide, affecting more than 30% of general population. High-fat diets, physical inactivity and obesity, all prevalent in the western societies, are strongly associated with the development and progression of NAFLD. Current drug therapies have not consistently shown substantial beneficial effects. Thus, lifestyle modification appears to be the optimal intervention in combating the disease. Accordingly, several studies have concluded that weight loss, via increase in physical activity, and dietary interventions could potential ameliorate biochemical, histological, and structural abnormalities of non-alcoholic fatty liver disease...
June 20, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28633440/low-alanine-aminotransferase-levels-in-the-elderly-frailty-disability-sarcopenia-and-reduced-survival
#9
Umberto Vespasiani-Gentilucci, Antonio De Vincentis, Luigi Ferrucci, Stefania Bandinelli, Raffaele Antonelli Incalzi, Antonio Picardi
Background: Although low alanine aminotransferase (ALT) levels have been associated with poor outcomes in the elderly, the determinants subtending this association have been poorly explored. To gain insight into this topic, we analyzed data from a prospective population-based database (InCHIANTI study) in which frailty, disability, sarcopenia and pyridoxine levels were systematically assessed. Methods: Data are from 765 participants aged >65 years (mean age 75...
June 19, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28630692/liver-fat-a-relevant-target-for-dietary-intervention-summary-of-a-unilever-workshop
#10
REVIEW
Harry P F Peters, Patrick Schrauwen, Petra Verhoef, Christopher D Byrne, David J Mela, Andreas F H Pfeiffer, Ulf Risérus, Frits R Rosendaal, Vera Schrauwen-Hinderling
Currently it is estimated that about 1 billion people globally have non-alcoholic fatty liver disease (NAFLD), a condition in which liver fat exceeds 5 % of liver weight in the absence of significant alcohol intake. Due to the central role of the liver in metabolism, the prevalence of NAFLD is increasing in parallel with the prevalence of obesity, insulin resistance and other risk factors of metabolic diseases. However, the contribution of liver fat to the risk of type 2 diabetes mellitus and CVD, relative to other ectopic fat depots and to other risk markers, is unclear...
2017: Journal of Nutritional Science
https://www.readbyqxmd.com/read/28629152/the-association-between-pediatric-nafld-and-common-genetic-variants
#11
REVIEW
Giuseppina Rosaria Umano, Mariangela Martino, Nicola Santoro
Non-alcoholic fatty liver disease (NAFLD) is one of the most common complications of obesity. Several studies have shown that genetic predisposition probably plays an important role in its pathogenesis. In fact, in the last few years a large number of genetic studies have provided compelling evidence that some gene variants, especially those in genes encoding proteins regulating lipid metabolism, are associated with intra-hepatic fat accumulation. Here we provide a comprehensive review of the gene variants that have affected the natural history of the disease...
June 18, 2017: Children
https://www.readbyqxmd.com/read/28628674/hepatic-microvascular-dysfunction-and-increased-advanced-glycation-end-products-are-components-of-non-alcoholic-fatty-liver-disease
#12
Evelyn Nunes Goulart da Silva Pereira, Raquel Rangel Silvares, Edgar Eduardo Ilaquita Flores, Karine Lino Rodrigues, Isalira Peroba Ramos, Igor José da Silva, Marcelo Pelajo Machado, Rosiane Aparecida Miranda, Carmen Cabanelas Pazos-Moura, Cassiano F Gonçalves-de-Albuquerque, Hugo Caire de Castro Faria-Neto, Eduardo Tibiriça, Anissa Daliry
BACKGROUND: This study aimed to investigate the pathophysiology of hepatic microcirculatory dysfunction in non-alcoholic fatty liver disease (NAFLD). METHODS: In Wistar rats, NAFLD model was induced by 20 weeks of high-fat diet (HFD) feeding. Rolling and adhesion of leukocytes and tissue perfusion in hepatic microcirculation were examined using in vivo microscopic and laser speckle contrast imaging (LSCI), respectively. Oxidative stress and inflamatory parameters were analysed by TBARs, catalase enzyme activity, RT-PCR and ELISA...
2017: PloS One
https://www.readbyqxmd.com/read/28619255/infant-nutrition-and-maternal-obesity-influence-the-risk-of-non-alcoholic-fatty-liver-disease-in-adolescents
#13
Oyekoya T Ayonrinde, Wendy H Oddy, Leon A Adams, Trevor A Mori, Lawrence J Beilin, Nicholas de Klerk, John K Olynyk
BACKGROUND & AIMS: The pathway to non-alcoholic fatty liver disease (NAFLD) in adolescents may have its origins in adiposity gains, nutrition and sedentary lifestyle established during childhood. There is inadequate knowledge regarding the associations between infant nutrition and subsequent NAFLD. We examined the association of maternal factors and infant nutrition, with the subsequent diagnosis of NAFLD in adolescents. METHODS: Adolescents aged 17years in the Western Australian Pregnancy (Raine) Cohort study had fatty liver assessment using liver ultrasound...
May 22, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28615690/cathepsin-d-regulates-lipid-metabolism-in-murine-steatohepatitis
#14
Tom Houben, Yvonne Oligschlaeger, Tim Hendrikx, Albert V Bitorina, Sofie M A Walenbergh, Patrick J van Gorp, Marion J J Gijbels, Silvia Friedrichs, Jogchum Plat, Frank G Schaap, Dieter Lütjohann, Marten H Hofker, Ronit Shiri-Sverdlov
Due to the obesity epidemic, non-alcoholic steatohepatitis (NASH) is a prevalent liver disease, characterized by fat accumulation and inflammation of the liver. However, due to a lack of mechanistic insight, diagnostic and therapeutic options for NASH are poor. Recent evidence has indicated cathepsin D (CTSD), a lysosomal enzyme, as a marker for NASH. Here, we investigated the function of CTSD in NASH by using an in vivo and in vitro model. In addition to diminished hepatic inflammation, inhibition of CTSD activity dramatically improved lipid metabolism, as demonstrated by decreased plasma and liver levels of both cholesterol and triglycerides...
June 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28615649/andrographolide-ameliorates-inflammation-and-fibrogenesis-and-attenuates-inflammasome-activation-in-experimental-non-alcoholic-steatohepatitis
#15
Daniel Cabrera, Alexander Wree, Davide Povero, Nancy Solís, Alejandra Hernandez, Margarita Pizarro, Han Moshage, Javiera Torres, Ariel E Feldstein, Claudio Cabello-Verrugio, Enrique Brandan, Francisco Barrera, Juan Pablo Arab, Marco Arrese
Therapy for nonalcoholic steatohepatitis (NASH) is limited. Andrographolide (ANDRO), a botanical compound, has a potent anti-inflammatory activity due to its ability to inhibit NF-κB. ANDRO has been also shown to inhibit the NLRP3 inflammasome, a relevant pathway in NASH. Our aim was to evaluate the effects of ANDRO in NASH and its influence on inflammasome activation in this setting. Thus, mice were fed a choline-deficient-amino-acid-defined (CDAA) diet with/without concomitant ANDRO administration (1 mg/kg, 3-times/week)...
June 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28608850/cellular-senescence-drives-age-dependent-hepatic-steatosis
#16
Mikolaj Ogrodnik, Satomi Miwa, Tamar Tchkonia, Dina Tiniakos, Caroline L Wilson, Albert Lahat, Christoper P Day, Alastair Burt, Allyson Palmer, Quentin M Anstee, Sushma Nagaraja Grellscheid, Jan H J Hoeijmakers, Sander Barnhoorn, Derek A Mann, Thomas G Bird, Wilbert P Vermeij, James L Kirkland, João F Passos, Thomas von Zglinicki, Diana Jurk
The incidence of non-alcoholic fatty liver disease (NAFLD) increases with age. Cellular senescence refers to a state of irreversible cell-cycle arrest combined with the secretion of proinflammatory cytokines and mitochondrial dysfunction. Senescent cells contribute to age-related tissue degeneration. Here we show that the accumulation of senescent cells promotes hepatic fat accumulation and steatosis. We report a close correlation between hepatic fat accumulation and markers of hepatocyte senescence. The elimination of senescent cells by suicide gene-meditated ablation of p16(Ink4a)-expressing senescent cells in INK-ATTAC mice or by treatment with a combination of the senolytic drugs dasatinib and quercetin (D+Q) reduces overall hepatic steatosis...
June 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/28603781/genome-wide-association-studies-candidate-gene-to-dual-modifier-of-nonalcoholic-steatohepatitis-and-atherosclerosis
#17
Clint L Miller, Nicholas J Leeper
Non-alcoholic steatohepatitis (NASH) is a common disease involving chronic accumulation of fat and inflammation in the liver, often leading to advanced fibrosis, cirrhosis and cancer. It is known that NASH shares many features with atherosclerosis, however, there are still no effective therapeutics. In a recent study published in Nature, investigators demonstrate that mice lacking a high-density lipoprotein (HDL)-associated gene were surprisingly protected from both steatohepatitis and atherosclerosis through the stabilization of the liver X receptor (LXR)...
December 2016: JACC. Basic to Translational Science
https://www.readbyqxmd.com/read/28596784/indy-a-new-link-to-metabolic-regulation-in-animals-and-humans
#18
REVIEW
Blanka Rogina
The Indy (I'm Not Dead Yet) gene encodes the fly homolog of the mammalian SLC13A5 citrate transporter. Reduced expression of the Indy gene in flies and worms extends their longevity. INDY is expressed in the plasma membrane of metabolically active tissues. Decreased expression of Indy in worms, flies, mice, and rats alters metabolism in a manner similar to calorie restriction. Reducing INDY activity prevents weight gain in flies, worms, and mice, and counteracts the negative effects of age or a high fat diet on metabolism and insulin sensitivity...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/28595132/functionality-based-method-for-simultaneous-isolation-of-rodent-hepatic-sinusoidal-cells
#19
L Stradiot, S Verhulst, T Roosens, C I Øie, I M Moya, G Halder, I Mannaerts, L A van Grunsven
Chronic liver disease is the result of long term exposure to viruses or toxins such as alcohol, fat and drugs, and forms the basis for the development of liver fibrosis and primary liver cancer. In vitro and in vivo models are key to study the pathways involved in chronic liver disease and for the development of therapeutics. 3D co-culture systems are becoming the in vitro standard, which requires freshly isolated primary hepatic cells. We developed a novel isolation method to simultaneously isolate liver sinusoidal endothelial cells (LSECs), Kupffer cells (KCs) and hepatic stellate cells (HSCs)...
September 2017: Biomaterials
https://www.readbyqxmd.com/read/28593786/characterization-of-liver-changes-in-zsf1-rats-an-animal-model-of-metabolic-syndrome
#20
Marta Borges Canha, José Pedro Portela-Cidade, Glória Conceição, Cláudia Sousa-Mendes, Sara Leite, Dulce Fontoura, Daniel Moreira-Gonçalves, Inês Falcão-Pires, André Lourenço, Adelino Leite-Moreira, Pedro Pimentel-Nunes
BACKGROUND: The non-alcoholic fatty liver disease is the hepatic counterpart of the metabolic syndrome. ZSF1 rats are a metabolic syndrome animal model in which liver changes have not been described yet. AIM: The characterization of liver histological and innate immunity changes in ZSF1 rats. METHODS: Five groups of rats were included (n = 7 each group): healthy Wistar-Kyoto control rats (Ctrl), hypertensive ZSF1 lean (Ln), ZSF1 obese rats with a normal diet (Ob), ZSF1 obese rates with a high-fat diet (Ob-HFD), and ZSF1 obese rats with low-intensity exercise training (Ob-Ex)...
June 8, 2017: Revista Española de Enfermedades Digestivas
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