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Minimal hepatic encephalopathy

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https://www.readbyqxmd.com/read/29580065/status-of-rifaximin-a-review-of-characteristics-uses-and-analytical-methods
#1
Ana Carolina Kogawa, Hérida Regina Nunes Salgado
Rifaximin, an oral antimicrobial, has many advantages because it is selective intestine, has minimal adverse effects and is used for the treatment of some diseases such as hepatic encephalopathy, irritable bowel syndrome, travelers' diarrhea, ulcerative colitis, Clostridium difficile and acute diarrhea. Rifaximin in the form of 200 mg tablets is commercially available. The crystalline α form is therapeutically safe and effective. In most of the official compendia, rifaximin has no monograph and in none of them is there a monograph for rifaximin tablets...
March 26, 2018: Critical Reviews in Analytical Chemistry
https://www.readbyqxmd.com/read/29551739/factors-that-affect-results-of-psychometric-tests-to-identify-patients-with-minimal-hepatic-encephalopathy
#2
Maria Camila Pérez-Matos, Z Gordon Jiang, Elliot B Tapper
No abstract text is available yet for this article.
March 15, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29533396/diagnosis-of-minimal-hepatic-encephalopathy-a-systematic-review-of-point-of-care-diagnostic-tests
#3
REVIEW
Elliot B Tapper, Neehar D Parikh, Akbar K Waljee, Michael Volk, Noelle E Carlozzi, Anna S-F Lok
OBJECTIVES: Minimal hepatic encephalopathy (HE) is common, characterized by deficits in reaction time and executive function, and strongly associated with disability and mortality. Point-of-care diagnostics performed without specialized skills or equipment are now available, albeit with limited data regarding their generalizability. METHODS: We systematically reviewed MEDLINE, EMBASE, Cochrane Library, and Scopus for diagnostic studies of MHE using broad search terms including HE and minimal, covert, or the names of published diagnostic modalities...
March 13, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29530628/critical-flicker-frequency-test-predicts-overt-hepatic-encephalopathy-and-survival-in-patients-with-liver-cirrhosis
#4
Michele Barone, Endrit Shahini, Andrea Iannone, Maria Teresa Viggiani, Valeria Corvace, Mariabeatrice Principi, Alfredo Di Leo
BACKGROUND: A critical flicker frequency (CFF) ≤39 Hz identifies cirrhotic patients with minimal hepatic encephalopathy (mHE) and predicts the risk of both overt hepatic encephalopathy (oHE) and mortality in patients with previous episodes of decompensation and/or oHE. AIMS: Herein, we evaluated the effectiveness of CFF in predicting the first episode of oHE and survival in cirrhotics who had never experienced an episode of oHE. METHODS: Our cohort study of 134 patients and 150 healthy subjects were examined...
January 31, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29522439/resveratrol-in-patients-with-minimal-hepatic-encephalopathy
#5
Giulia Malaguarnera, Manuela Pennisi, Gaetano Bertino, Massimo Motta, Antonio Maria Borzì, Enzo Vicari, Rita Bella, Filippo Drago, Michele Malaguarnera
BACKGROUND: Minimal Hepatic Encephalopathy (MHE) is characterized by an impairment of social interaction, emotional behavior, sleep disorders, physical and mental symptoms, and diminished Quality of Life (QoL). The aim of our study is evaluating the potential liver health promoting a perspective of Resveratrol (RV) activities and evaluate whether RV treatment may improve health related quality of life (HRQL) and reduce depression and anxiety in patients with MHE. METHODS: W e evaluated depression using the Beck Depression Inventory test, anxiety with State-trait anxiety inventory test, quality of life through SF-36 test, and ammonia serum levels in 70 MHE patients that were randomized into two groups...
March 9, 2018: Nutrients
https://www.readbyqxmd.com/read/29521513/considerations-for-the-cost-effective-management-of-hepatic-encephalopathy
#6
Steven L Flamm
Hepatic encephalopathy (HE) is a neuropsychiatric complication commonly associated with liver disease, namely cirrhosis. The inability of the liver to metabolize ammonia results in a buildup of ammonia, which can cross the blood-brain barrier and cause significant neurocognitive impairment. Up to 80% of patients with cirrhosis will experience HE and a large proportion of these patients are at high risk of recurrent HE. There are several factors to consider when developing a cost-effective approach to managing HE, such as patient compliance, the adverse event (AE) profile of drug therapy, efficacy of drug therapy, and relative cost-benefits of drug therapy...
March 2018: American Journal of Managed Care
https://www.readbyqxmd.com/read/29507462/the-burden-of-minimal-hepatic-encephalopathy-from-diagnosis-to-therapeutic-strategies
#7
REVIEW
Lorenzo Ridola, Vincenzo Cardinale, Oliviero Riggio
Minimal hepatic encephalopathy (MHE) is the mildest form of hepatic encephalopathy (HE). It affects the performance of psychometric tests focused on attention, working memory, psychomotor speed, and visuospatial ability, as well as electrophysiological and other functional brain measures. MHE is a frequent complication of liver disease, affecting up to 80% of tested patients. By being related to falls, an impairment in fitness to drive and the development of overt HE, MHE severely affects the lives of patients and caregivers by altering their quality of life and their socioeconomic status...
March 2018: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29464506/idiopathic-portal-hypertension-and-extrahepatic-portal-venous-obstruction
#8
REVIEW
Rajeev Khanna, Shiv Kumar Sarin
BACKGROUND: Idiopathic portal hypertension (IPH) and extrahepatic portal venous obstruction (EHPVO) are non-cirrhotic vascular causes of portal hypertension (PHT). Variceal bleed and splenomegaly are the commonest presentations. AIM: The present review is intended to provide the existing literature on etiopathogenesis, clinical profile, diagnosis, natural history and management of IPH and EHPVO. RESULTS: IPH and EHPVO are both characterized by normal hepatic venous pressure gradient, moderate to massive splenomegaly with preserved liver synthetic functions...
February 20, 2018: Hepatology International
https://www.readbyqxmd.com/read/29445232/the-cerebellum-of-patients-with-steatohepatitis-shows-lymphocyte-infiltration-microglial-activation-and-loss-of-purkinje-and-granular-neurons
#9
Tiziano Balzano, Jerónimo Forteza, Pilar Molina, Juan Giner, Ana Monzó, Jennifer Sancho-Jiménez, Amparo Urios, Carmina Montoliu, Vicente Felipo
Peripheral inflammation contributes to minimal hepatic encephalopathy in chronic liver diseases, which could be mediated by neuroinflammation. Neuroinflammation in cerebellum of patients with chronic liver diseases has not been studied in detail. Our aim was to analyze in cerebellum of patients with different grades of liver disease, from mild steatohepatitis to cirrhosis and hepatic encephalopathy: (a) neuronal density in Purkinje and granular layers; (b) microglial activation; (c) astrocyte activation; (d) peripheral lymphocytes infiltration; (e) subtypes of lymphocytes infiltrated...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29428113/effect-of-probiotic-treatment-on-cirrhotic-patients-with-minimal-hepatic-encephalopathy-a-meta-analysis
#10
Qing Cao, Cheng-Bo Yu, Shi-Gui Yang, Hong-Cui Cao, Ping Chen, Min Deng, Lan-Juan Li
BACKGROUND: Minimal hepatic encephalopathy (MHE) is an early and reversible form of hepatic encephalopathy. The documentations on the treatment with probiotics are inconsistent. The present meta-analysis was to verify the role of probiotics in the treatment of cirrhotic patients with MHE. DATA SOURCES: Seven electronic databases were searched for relevant randomized controlled trials (RCTs) published until July 2015. The effects of probiotics on serum ammonia, endotoxin, and MHE were evaluated...
February 2018: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/29416060/repeated-measures-of-blood-and-breath-ammonia-in-response-to-control-moderate-and-high-protein-dose-in-healthy-men
#11
Lisa A Spacek, Arthur Strzepka, Saurabh Saha, Jonathan Kotula, Jeffrey Gelb, Sarah Guilmain, Terence Risby, Steven F Solga
Ammonia physiology is important to numerous disease states including urea cycle disorders and hepatic encephalopathy. However, many unknowns persist regarding the ammonia response to common and potentially significant physiologic influences, such as food. Our aim was to evaluate the dynamic range of ammonia in response to an oral protein challenge in healthy participants. We measured blood and breath ammonia at baseline and every hour for 5.5 hours. Healthy men (N = 22, aged 18 to 24 years) consumed a 60 g protein shake (high dose); a subset of 10 consumed a 30 g protein shake (moderate dose) and 12 consumed an electrolyte drink containing 0 g protein (control)...
February 7, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29404643/baicalin-reverses-the-impairment-of-synaptogenesis-induced-by-dopamine-burden-via-the-stimulation-of-gabaar-trkb-interaction-in-minimal-hepatic-encephalopathy
#12
Saidan Ding, Weishan Zhuge, Jiangnan Hu, Jianjing Yang, Xuebao Wang, Fangfang Wen, Chengde Wang, Qichuan Zhuge
BACKGROUND: It has been reported that D1 receptor (D1R) activation reduces GABAA receptor (GABAAR) current, and baicalin (BAI) displays therapeutic efficacy in diseases involving cognitive impairment. METHODS: We investigated the mechanisms by which BAI could improve DA-induced minimal hepatic encephalopathy (MHE) using immunoblotting, immunofluorescence, and co-immunoprecipitation. RESULTS: BAI did not induce toxicity on the primary cultured neurons...
February 6, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29373442/stroop-test-validation-to-screen-for-minimal-hepatic-encephalopathy-in-pediatric-extrahepatic-portal-venous-obstruction
#13
Meera Vyshni Suresh, Barath Jagadisan, Preeti Kandasamy, Gandhipuram Periyasamy Senthilkumar
OBJECTIVES: Minimal Hepatic encephalopathy (MHE) has been reported in children with extra hepatic portal vein obstruction (EHPVO). MHE assessment is restricted to research situations as neuropsychiatric tests are time-intensive. Computerised Stroop Test (CST) has been used in cirrhotic adults for MHE screening. The study aims to assess MHE frequency in young Indian children with EHPVO and validate CST for MHE screening in pediatric EHPVO METHODS:: 37 children with EHPVO between 7-12 years of age and 37 age and gender matched controls were enrolled...
January 25, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29356589/polytetrafluoroethylene-covered-stent-graft-versus-bare-stent-in-transjugular-intrahepatic-portosystemic-shunt-systematic-review-and-meta-analysis
#14
Tania Triantafyllou, Piyush Aggarwal, Ekansh Gupta, Wendy Jo Svetanoff, Deepak Prakash Bhirud, Saurabh Singhal
BACKGROUND & AIMS: Transjugular Intrahepatic Portosystemic Shunt (TIPS) is used to control refractory variceal bleeding secondary to portal hypertension. This meta-analysis was conducted to systematically review polytetrafluoroethylene-covered stent grafts (CS) versus bare stents (BS) in TIPS procedure. METHODS: Systematic search of literature databases was done from January-1990 till April-2017, using predecided keywords. Outcome measures studied were (1) primary-patency (PP) at 1 year (defined as absence of shunt insufficiency at 1 year), (2) rebleeding (RE) (3) new-onset hepatic encephalopathy ([HE] new-onset or worsening encephalopathy following the procedure), and (4) survival at 1 year (SU)...
January 22, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29341965/osmotic-shifts-cerebral-edema-and-neurologic-deterioration-in-severe-hepatic-encephalopathy
#15
Eric Michael Liotta, Anna L Romanova, Bryan D Lizza, Laura J Rasmussen-Torvik, Minjee Kim, Brandon Francis, Rajbeer Singh Sangha, Timothy J Carroll, Daniel Ganger, Daniela P Ladner, Andrew M Naidech, James J Paparello, Shyam Prabhakaran, Farzaneh A Sorond, Matthew B Maas
OBJECTIVES: We sought to determine the effect of acute electrolyte and osmolar shifts on brain volume and neurologic function in patients with liver failure and severe hepatic encephalopathy. DESIGN: Retrospective analysis of brain CT scans and clinical data. SETTING: Tertiary care hospital ICUs. PATIENTS: Patients with acute or acute-on-chronic liver failure and severe hepatic encephalopathy. INTERVENTIONS: Clinically indicated CT scans and serum laboratory studies...
February 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29318932/decreased-taurine-and-creatine-in-the-thalamus-may-relate-to-behavioral-impairments-in-ethanol-fed-mice-a-pilot-study-of-proton-magnetic-resonance-spectroscopy
#16
Su Xu, Wenjun Zhu, Yamin Wan, JiaBei Wang, Xi Chen, Liya Pi, Mary Kay Lobo, Bin Ren, Zhekang Ying, Michael Morris, Qi Cao
Minimal hepatic encephalopathy (MHE) is highly prevalent, observed in up to 80% of patients with liver dysfunction. Minimal hepatic encephalopathy is defined as hepatic encephalopathy with cognitive deficits and no grossly evident neurologic abnormalities. Clinical management may be delayed due to the lack of in vivo quantitative methods needed to reveal changes in brain neurobiochemical biomarkers. To gain insight into the development of alcoholic liver disease-induced neurological dysfunction (NDF), a mouse model of late-stage alcoholic liver fibrosis (LALF) was used to investigate changes in neurochemical levels in the thalamus and hippocampus that relate to behavioral changes...
January 2018: Molecular Imaging
https://www.readbyqxmd.com/read/29308002/disabling-portosystemic-encephalopathy-in-a-non-cirrhotic-patient-successful-endovascular-treatment-of-a-giant-inferior-mesenteric-caval-shunt-via-the-left-internal-iliac-vein
#17
Luca de Martinis, Gloria Groppelli, Riccardo Corti, Lorenzo Paolo Moramarco, Pietro Quaretti, Pasquale De Cata, Mario Rotondi, Luca Chiovato
Hepatic encephalopathy is suspected in non-cirrhotic cases of encephalopathy because the symptoms are accompanied by hyperammonaemia. Some cases have been misdiagnosed as psychiatric diseases and consequently patients hospitalized in psychiatric institutions or geriatric facilities. Therefore, the importance of accurate diagnosis of this disease should be strongly emphasized. A 68-year-old female patient presented to the Emergency Room with confusion, lethargy, nausea and vomiting. Examination disclosed normal vital signs...
December 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29216388/insulin-resistance-disrupts-the-interaction-between-akt-and-the-nmda-receptor-and-the-inactivation-of-the-camkiv-creb-pathway-in-minimal-hepatic-encephalopathy
#18
Saidan Ding, Weishan Zhuge, Jianjing Yang, Fangfang Wen, Zhu Xu, Xuebao Wang, Qichuan Zhuge
No abstract text is available yet for this article.
January 1, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29201772/managing-encephalopathy-in-the-outpatient-setting
#19
REVIEW
Tarana Gupta, Sahaj Rathi, Radha K Dhiman
In cirrhosis of liver, hepatic encephalopathy (HE) has an important impact on health-related quality of life. It is important to define whether HE is episodic, recurrent, or persistent; types A, B, or C; overt HE or covert HE; and spontaneous or precipitated. The overt HE is clinically evident and needs hospitalization. Nonabsorbable disaccharides, rifaximin, and probiotics are proven to be useful in the treatment of overt HE. Covert HE includes both minimal HE and grade I HE. It is not apparent on routine clinical examination...
January 2017: Euroasian journal of hepato-gastroenterology
https://www.readbyqxmd.com/read/29201193/effect-of-different-treatments-and-alcohol-addiction-on-gut-microbiota-in-minimal-hepatic-encephalopathy-patients
#20
Zan Zuo, Hong Fan, Xiao-Dan Tang, Yan-Min Chen, Lin-Ting Xun, Yan Li, Zheng-Ji Song, Hui-Qiong Zhai
Minimal hepatic encephalopathy (MHE) is caused by dysbiosis of gut microbiota, particularly the ammonia-producing bacteria. Given the efficacy of certain treatments on MHE and the connection between alcoholism and MHE, a thorough understanding of how these strategies affect the gut microbiota in patients (alcoholic or non-alcoholic) will facilitate the assessment of their efficacy in the reshaping of gut microbiota. In the present study, a metagenomics approach was adopted to reveal alterations in gut microbiota of 14 MHE patients following treatment with rifaximin alone or rifaximin plus probiotics...
November 2017: Experimental and Therapeutic Medicine
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