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Lactose intolerance

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https://www.readbyqxmd.com/read/28801371/small-intestinal-bacterial-overgrowth-may-increase-the-likelihood-of-lactose-and-sorbitol-but-not-fructose-intolerance-false-positive-diagnosis
#1
Tsachi Tsadok Perets, Dalal Hamouda, Olga Layfer, Olga Ashorov, Doron Boltin, Sigal Levy, Yaron Niv, Ram Dickman
BACKGROUND: Small intestinal bacterial overgrowth (SIBO) is defined as a bacterial count of more than 10(5) colony-forming units per milliliter in duodenal aspirate. It shares many symptoms with carbohydrate intolerance, which makes the clinical distinction of the disorders difficult. The aim of the study was to examine the relationship between a positive carbohydrate breath test and the presence of SIBO suggested by a positive lactulose hydrogen breath test. METHODS: The electronic database of the gastroenterology laboratory of a tertiary medical center was searched for all patients clinically tested for SIBO in 2012-2013 for whom previous results for lactose, fructose, and/or sorbitol breath test were available...
August 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28738753/genetic-predictors-of-celiac-disease-lactose-intolerance-and-vitamin-d-function-and-presence-of-peptide-morphins-in-urine-of-children-with-neurodevelopmental-disorders
#2
Katarina Bojović, Biljana Stanković, Nikola Kotur, Dijana Krstić-Milošević, Vladimir Gašić, Sonja Pavlović, Branka Zukić, Đurđica Ignjatović
Gastrointestinal disturbances, nutritional deficiencies, and food intolerances are frequently observed in children with neurodevelopmental disorders (NDD). To reveal possible association of celiac disease risk variants (HLA-DQ), lactose intolerance associated variant (LCT-13910C>T) as well as variant associated with vitamin D function (VDR FokI) with NDD, polymerase chain reaction-based methodology was used. Additionally, intestinal peptide permeability was estimated in NDD patients and healthy children by measuring the level of peptides in urine using high-performance liquid chromatography...
July 24, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28702130/new-insights-in-ibs-like-disorders-pandora-s-box-has-been-opened-a-review
#3
REVIEW
Raffaele Borghini, Giuseppe Donato, Domenico Alvaro, Antonio Picarelli
The most complained gastrointestinal symptoms are chronic diarrhea, bloating and abdominal pain. Once malignancies and inflammatory bowel diseases are excluded, irritable bowel syndrome (IBS) and the so called "IBS-like disorders" should be taken into account. The relationship between IBS as defined by Rome IV criteria and these clinical conditions is sometimes obscure, since many IBS patients identify food as a possible trigger for their symptoms. Here, we discuss IBS and the most common IBS-like disorders (celiac disease, non-celiac gluten sensitivity, fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs), lactose intolerance, small intestinal bacterial overgrowth (SIBO), α-amylase/trypsin inhibitor (ATIs), nickel allergic contact mucositis), focusing on epidemiologic, clinical, diagnostic and therapeutic aspects...
2017: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/28680560/health-related-quality-of-life-among-schoolchildren-aged-12-13%C3%A2-years-in-relation-to-food-hypersensitivity-phenotypes-a-population-based-study
#4
Åsa Strinnholm, Linnéa Hedman, Anna Winberg, Sven-Arne Jansson, Viveca Lindh, Eva Rönmark
BACKGROUND: While Health Related Quality of Life has been investigated among children with IgE-mediated food allergy, less is known about quality of life among children with other types of hypersensitivity to food. The aim of this study was to investigate Health Related Quality of Life (HRQL) in children with and without food hypersensitivity. Further, we compared HRQL between children with different phenotypes of food hypersensitivity. METHODS: In a large population-based cohort of schoolchildren in Northern Sweden, the parents of 2612 (96% of invited) completed a questionnaire...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28672432/pros-and-cons-while-looking-through-an-asian-window-on-the-rome-iv-criteria-for-irritable-bowel-syndrome-pros
#5
REVIEW
Uday C Ghoshal
A decade after Rome III, in 2016, Rome IV criteria were published. There are major differences between Rome IV and the earlier iteration, some of which are in line with Asian viewpoints. The clinical applicability of the Rome IV criteria of irritable bowel syndrome (IBS) in Asian perspective is reviewed here. Instead of considering functional gastrointestinal disorders (FGIDs) to be largely psychogenic, Rome IV suggested the importance of the gut over brain ("disorders of gut-brain interaction" not "brain-gut interaction")...
July 30, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28623320/postprandial-metabolic-response-of-breast-fed-infants-and-infants-fed-lactose-free-vs-regular-infant-formula-a-randomized-controlled-trial
#6
Carolyn M Slupsky, Xuan He, Olle Hernell, Yvonne Andersson, Colin Rudolph, Bo Lönnerdal, Christina E West
Lactose intolerance is a major concern driving the growth of lactose-free foods including lactose-free infant formula. It is unknown what the metabolic consequence is of consumption of a formula where lactose has been replaced with corn syrup solids (CSS). Here, a randomized double-blinded intervention study was conducted where exclusively formula-fed infants were fed formula containing either lactose or CSS-based infant formula and compared with an equal number of exclusively breast-fed infants. Plasma metabolites and insulin were measured at baseline, 15, 30, 60, 90 and 120 min after feeding...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28576377/microbiological-biochemical-and-functional-aspects-of-sugary-kefir-fermentation-a-review
#7
REVIEW
Fernanda Assumpção Fiorda, Gilberto Vinicius de Melo Pereira, Vanete Thomaz-Soccol, Sudip Kumar Rakshit, Maria Giovana Binder Pagnoncelli, Luciana Porto de Souza Vandenberghe, Carlos Ricardo Soccol
Sugary kefir beverage is produce by fermenting raw sugar solution with kefir grains, the latter consisting of polysaccharide and microorganisms. This beverage, with great consumption in countries such as USA, Japan, France, and Brazil, represents a promising market to functional cultured drinks. This paper reviews the microbial diversity and interaction, kinetics, safety, and bioactivities of sugary kefir fermentation. The literature reviewed here demonstrates that sugary kefir possesses a similar microbial association relative to traditional milk kefir fermentation, especially among lactic acid bacteria and yeast species, such as Lactobacillus, Leuconostoc, Kluyveromyces, Pichia, and Saccharomyces...
September 2017: Food Microbiology
https://www.readbyqxmd.com/read/28530589/comparison-of-hplc-ri-lc-ms-ms-and-enzymatic-assays-for-the-analysis-of-residual-lactose-in-lactose-free-milk
#8
COMPARATIVE STUDY
A Trani, G Gambacorta, P Loizzo, A Cassone, C Fasciano, A V Zambrini, M Faccia
Lactose intolerance is the decreased ability to digest lactose, and the population involved is rapidly increasing all over the world. Different procedures have been reported in the literature to quantify lactose in dairy products, but the official method of analysis is based on enzymatic assay. In this paper, the effectiveness of two enzymatic kits in detecting residual lactose in lactose-free milk was investigated, and a comparison with two alternative chromatographic methods was done. The investigation used several samples of UHT milk containing different levels of lactose, and the results highlighted the inadequacy of the enzymatic assays and of the HPLC-RI method to analyse lactose-free milk...
October 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28521673/simple-strategy-to-protect-lactase-activity-in-solid-formulation
#9
Aline Gravinez Perissinato, André Luis Morais Ruela, Gislaine Ribeiro Pereira, Jerusa Simone Garcia, Marcello Garcia Trevisan
Lactose intolerance is characterized by the absence of the enzyme lactase (beta-galactosidase) and affects two thirds of the world adult population. Our aim was to evaluate a lactase gastro formulation to ensure increased activity in the action site of the enzyme (lumen of the small intestine). Simultaneously, we also evaluated the commercial product stability and enzyme activity. When carrying out dissolution test in commercial product it is noted that the existing formulation is not able to protect the enzyme from degrading action of gastric environment (a loss of 86...
May 18, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28500401/sources-of-%C3%AE-galactosidase-and-its-applications-in-food-industry
#10
REVIEW
Shaima Saqib, Attiya Akram, Sobia Ahsan Halim, Raazia Tassaduq
The enzyme β-galactosidases have been isolated from various sources such as bacteria, fungi, yeast, vegetables, and recombinant sources. This enzyme holds importance due to its wide applications in food industries to manufacture lactose-hydrolyzed products for lactose-intolerant people and the formation of glycosylated products. Absorption of undigested lactose in small intestine requires the activity of this enzyme; hence, the deficiency of this enzyme leads to lactose intolerance. Lactose intolerance affects around 70% of world's adult population, while the prevalence rate of lactose intolerance is 60% in Pakistan...
May 2017: 3 Biotech
https://www.readbyqxmd.com/read/28497837/frequency-of-adult-type-associated-lactase-persistence-lct-13910c-t-genotypes-in-the-czech-slav-and-czech-roma-gypsy-populations
#11
Jaroslav A Hubácek, Věra Adámková, Lenka Šedová, Věra Olišarová, Václav Adámek, Valérie Tóthová
Lactase non-persistence (leading to primary lactose intolerance) is a genetically dependent inability to digest lactose in adulthood. As part of the human adaptation to dairying, the human lactase LCT-13910C/T mutation (which propagates adult expression of lactase) developed, spread and participated in the adaptation to dairying. This variant is associated with lactase activity persistence, and its carriers are able to digest lactose. We compared the frequencies of lactase 13910C/T (rs4988235) genotypes in Czechs/Slavs (N = 288) and Czech Gypsies/Roma (N = 300), two ethnically different groups where this polymorphism has not yet been analysed...
April 2017: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/28476114/restaurant-based-intervention-to-facilitate-healthy-eating-choices-and-the-identification-of-allergenic-foods-at-a-family-oriented-resort-and-a-campground
#12
Lucia Tarro, Magaly Aceves-Martins, Yolanda Tiñena, Joan Lluís Parisi, Xavier Blasi, Montse Giralt, Elisabet Llauradó, Rosa Solà
BACKGROUND: Restaurant-based interventions can be an enjoyable way to encourage healthier eating choices by all members of a family. Thus, the principal aims of this study were a) to promote healthy diets by increasing healthy food offerings and b) to increase the number of foods offered specifically as gluten-free and lactose-free and to inform patrons by including nutritional and allergen information that complies with Regulation 1169/2011 regarding the food served in restaurants, takeaways and snack bars...
May 5, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28460946/the-quality-of-low-lactose-milk-is-affected-by-the-side-proteolytic-activity-of-the-lactase-used-in-the-production-process
#13
Antonio Dario Troise, Enrica Bandini, Roberta De Donno, Geert Meijer, Marco Trezzi, Vincenzo Fogliano
Lactose intolerance syndrome can be efficiently tackled consuming low lactose products. Lactase is the key tool to manufacture low lactose milk (LLM): its addition during milk processing can be done "in batch", i.e. before thermal treatment, or directly "in pack" after sterilization. In this paper data on sensory properties, Maillard Reaction products (MRPs) and free amino acids formation were obtained on six commercial Italian LLMs over six months storage. They showed that the side proteolytic activity of lactase caused the release of amino acids with a significant higher MRPs and off-flavors formation in four out of five samples produced by adding the enzyme in the pack after thermal treatment...
November 2016: Food Research International
https://www.readbyqxmd.com/read/28446633/lactose-intolerance-lct-13910c-t-genotype-is-associated-with-plasma-25-hydroxyvitamin-d-concentrations-in-caucasians-a-mendelian-randomization-study
#14
Ohood Alharbi, Ahmed El-Sohemy
Background: The LCT-13910C>T gene variant is associated with lactose intolerance (LI) in different ethnic groups. Individuals with LI often limit or avoid dairy consumption, a major dietary source of vitamin D in North America, which may lead to inadequate vitamin D intake.Objective: The objective was to determine the prevalence of genotypes predictive of LI in different ethnic groups living in Canada and to determine whether the LCT genotype is associated with plasma 25(OH)D concentrations.Methods: Blood samples were drawn from a total of 1495 men and women aged 20-29 y from the Toronto Nutrigenomics and Health Study for genotyping and plasma 25(OH)D analysis...
June 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28421381/lactase-non-persistence-and-lactose-intolerance
#15
REVIEW
Theodore M Bayless, Elizabeth Brown, David M Paige
PURPOSE OF REVIEW: To evaluate the clinical and nutritional significance of genetically determined lactase non-persistence and potential lactose and milk intolerance in 65-70% of the world's adult population. RECENT FINDINGS: Milk consumption is decreasing in the USA and is the lowest in countries with a high prevalence of lactase non-persistence. The dairy industry and Minnesota investigators have made efforts to minimize the influence of lactose intolerance on milk consumption...
May 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28405073/benign-pancreatic-hyperenzymemia-gullo-syndrome-histamine-intolerance-and-carbohydrate-malabsorption
#16
Wolfgang J Schnedl, Dietmar Enko, Harald Mangge, Michael Schenk, Sonja Lackner, Sandra J Holasek
Benign pancreatic hyperenzymemia (Gullo syndrome) is characterized by a more than threefold increase of the pancreatic enzymes lipase and amylase in the absence of a pancreatic disease over a period of more than 1 year, with elevations and significant undulations of pancreatic enzyme serum concentrations occurring on a day-to-day basis for 5 consecutive days. Nonspecific abdominal complaints may be caused by carbohydrate and/or protein malabsorption. We report a patient with benign pancreatic hyperenzymemia with lactose and histamine malabsorption; the symptoms of gastrointestinal malabsorption were treated successfully with an individually tailored lactose- and histamine-free diet...
April 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28397685/-lactose-malabsorption-and-intolerance-who-will-benefit-from-a-lactose-reduced-diet
#17
Mikkel Malham, Anne Bille Olin, Anders Pærregaard
During the last decade, lactose-free diets have become increasingly popular in the general population, either isolated or as a part of a cow's milk-free diet. However, health-related benefits from a lactose-free diet are only documented for individuals with clinical lactose intolerance due to decreased intestinal lactase activity and subsequent lactose malabsorption. In this paper we summarize the current knowledge of lactose intolerance regarding diagnostic procedures and treatment.
February 6, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28318180/comparison-of-an-increased-waist-circumference-with-a-positive-hydrogen-breath-test-as-a-clinical-predictor-of-lactose-intolerance
#18
Carlos A Zapata-Castilleja, Fernando F Montes-Tapia, Consuelo Treviño-Garza, María C Martínez-Cobos, Jesús García-Cantú, Vincenzo Arenas-Fabbri, Norma de la O-Escamilla, Manuel de la O-Cavazos
INTRODUCTION: Lactose intolerance is a common disease in pediatrics, and its wrong diagnosis will lead to morbidity. The primary objective of this study was to assess the usefulness of an increased waist circumference during the hydrogen breath test as a predictor of lactose intolerance. The secondary objective was to analyze the impact of body mass index, waist circumference measurement, and age on the abdominal distension of patients with lactose intolerance. POPULATION AND METHODS: A total of 138 subjects aged 3 to 15 years were included...
April 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28296755/inflammatory-bowel-diseases-a-burden-in-pediatrics-case-series-and-a-review-of-the-literature
#19
Cristina Oana Mărginean, Lorena Elena Meliţ, Simona Mocanu, Maria Oana Mărginean
INTRODUCTION: Inflammatory bowel disease is a chronic condition of the gastrointestinal tract, comprising mainly Crohn disease (CD) and ulcerative colitis (UC). Both of them are frequently encountered in children, being multifactorial conditions, with an unclear etiology. PATIENTS CONCERNS: We present 4 cases of inflammatory bowel disease (IBD) in children in order to underline the variable evolution depending on the patient's particularities. DIAGNOSIS, INTERVENTIONS AND OUTCOMES: The first case, a 13-year-old male patient, with a history of Henoch-Schonlein purpura, was admitted for rectal bleeding and weight loss, with normal laboratory parameters...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28264511/prevention-of-bacterial-contamination-of-a-silica-matrix-containing-entrapped-%C3%AE-galactosidase-through-the-action-of-covalently-bound-lysozymes
#20
Heng Li, Shuai Li, Pu Tian, Zhuofu Wu, Zhengqiang Li
β-galactosidase was successfully encapsulated within an amino-functionalised silica matrix using a "fish-in-net" approach and molecular imprinting technique followed by covalent binding of lysozyme via a glutaraldehyde-based method. Transmission electron microscopy (TEM), X-ray diffraction (XRD), scanning electron microscopy (SEM), and Fourier transform infrared (FTIR) spectroscopy were used to characterise the silica matrix hosting the two enzymes. Both encapsulated β-galactosidase and bound lysozyme exhibited high enzymatic activities and outstanding operational stability in model reactions...
February 28, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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