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https://www.readbyqxmd.com/read/29245171/effects-of-atorvastatin-on-autophagy-in-skeletal-muscles-of-diabetic-rats
#1
Bingquan Yang, Jie Sun, Yang Yuan, Zilin Sun
AIMS/INTRODUCTION: Atorvastatin is usually used to decrease the amount of fatty substances in individuals with type 2 diabetes mellitus. However, it can cause side effects, such as breakdown of skeletal muscle tissue. This study focuses on the effects of atorvastatin on autophagy of the skeletal muscles in diabetic rats. MATERIALS AND METHODS: Diabetes in rats in the diabetic (D) and atorvastatin (T) groups was induced using streptozotocin (65 mg/kg, intraperitoneal injection)...
December 15, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29244621/on-mourning-and-recovery-integrating-stages-of-grief-and-change-toward-a-neuroscience-based-model-of-attachment-adaptation-in-addiction-treatment
#2
R Andrew Chambers, Sue C Wallingford
Interpersonal attachment and drug addiction share many attributes across their behavioral and neurobiological domains. Understanding the overlapping brain circuitry of attachment formation and addiction illuminates a deeper understanding of the pathogenesis of trauma-related mental illnesses and comorbid substance use disorders, and the extent to which ending an addiction is complicated by being a sort of mourning process. Attention to the process of addiction recovery-as a form of grieving-in which Kubler-Ross's stages of grief and Prochaska's stages of change are ultimately describing complementary viewpoints on a general process of neural network and attachment remodeling, could lead to more effective and integrative psychotherapy and medication strategies...
2017: Psychodynamic Psychiatry
https://www.readbyqxmd.com/read/29244540/overcoming-impediments-to-otp-expansion-in-the-united-states-and-abroad
#3
Mark W Parrino
By all published accounts and federal government reports, the United States is experiencing a serious opioid use epidemic. Additional treatment resources are needed in order to provide access to evidence based medical care for untreated individuals with substance use disorders. The focus of this commentary is increasing access to more opioid treatment programs and overcoming the significant impediments, which block such efforts.
December 15, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/29244264/personality-traits-and-anxiety-and-depressive-disorders-in-patients-with-medication-overuse-headache-versus-episodic-migraine
#4
Nima Mohseni, Mansooreh Togha, Seyed Masoud Arzaghi, Sepideh Nekooie, Mehrnaz Fallah Tafti, Farzad Fatehi
Objective: An episodic migraine (EM) may lead to medication-overuse headache (MOH), an abnormal behavioral pattern of noncompliance. Anxiety disorders, mood disorders, and disorders caused by psychoactive substances other than analgesics all have been reported with MOH at higher rates than with EM. The objective of this study was to evaluate the relationships between personality traits and anxiety and depressive disorders and headache type. Methods: In this cross-sectional study, 55 patients with EM and 50 patients with MOH were recruited from were recruited from 2 university hospital clinics in Tehran, Iran, from January 2013 to November 2015...
December 14, 2017: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/29244202/mental-health-risk-adjustment-with-clinical-categories-and-machine-learning
#5
Akritee Shrestha, Savannah Bergquist, Ellen Montz, Sherri Rose
OBJECTIVE: To propose nonparametric ensemble machine learning for mental health and substance use disorders (MHSUD) spending risk adjustment formulas, including considering Clinical Classification Software (CCS) categories as diagnostic covariates over the commonly used Hierarchical Condition Category (HCC) system. DATA SOURCES: 2012-2013 Truven MarketScan database. STUDY DESIGN: We implement 21 algorithms to predict MHSUD spending, as well as a weighted combination of these algorithms called super learning...
December 15, 2017: Health Services Research
https://www.readbyqxmd.com/read/29243862/effects-of-sodium-benzoate-a-commonly-used-food-preservative-on-learning-memory-and-oxidative-stress-in-brain-of-mice
#6
Mohammad Javad Khoshnoud, Asma Siavashpour, Mojgan Bakhshizadeh, Marzieh Rashedinia
Sodium benzoate (SB) is a widely used preservative and antimicrobial substance in many foods and soft drinks. However, this compound is generally recognized as safe food additives, but evidence has suggested that a high intake of SB may link to attention deficit-hyperactivity disorder in children. Present study investigate the effects of oral administration of different concentrations of SB (0.56, 1.125, and 2.25 mg/mL) for 4 weeks, on the learning and memory performance tests, and also the levels of malondialdehyde (MDA), reduced glutathione (GSH), and acetylcholinesterase activity (AChE) in the mouse brain...
December 15, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29242985/increasing-risk-of-psychiatric-morbidity-after-childhood-onset-type-1-diabetes-a-population-based-cohort-study
#7
Daniel Dybdal, Janne S Tolstrup, Stine M Sildorf, Kirsten A Boisen, Jannet Svensson, Anne Mette Skovgaard, Grete K Teilmann
AIMS/HYPOTHESIS: The aim of this study was to investigate psychiatric morbidity following childhood onset of type 1 diabetes. METHODS: In a matched, population-based cohort study based on Danish national registers, we identified children and adolescents who had been diagnosed as an in- or outpatient with type 1 diabetes before the age of 18, and afterwards diagnosed with a psychiatric disorder (n = 5084). Control individuals were matched according to sex and date of birth (n = 35,588)...
December 14, 2017: Diabetologia
https://www.readbyqxmd.com/read/29241988/disparities-in-operative-outcomes-in-patients-with-comorbid-mental-illness
#8
Elizabeth A Bailey, Christopher Wirtalla, Catherine E Sharoky, Rachel R Kelz
BACKGROUND: Patients with mental health disorders have worse medical outcomes and experience excess mortality compared with those without a mental health comorbidity. This study aimed to evaluate the relationship between mental health comorbidities and surgical outcomes. METHODS: This retrospective cohort study used the National Inpatient Sample (2009-2011) to select patients who underwent one of the 4 most common general surgery procedures (cholecystectomy and common duct exploration, colorectal resection, excision and lysis of peritoneal adhesions, and appendectomy)...
December 11, 2017: Surgery
https://www.readbyqxmd.com/read/29241432/correlates-of-reduced-violent-behavior-among-patients-receiving-intensive-treatment-for-posttraumatic-stress-disorder
#9
Alec Buchanan, Elina Stefanovics, Robert A Rosenheck
OBJECTIVE: Posttraumatic stress disorder (PTSD) has been linked to violent behavior, especially among military personnel returning from service in a war zone. Little is known, however, about whether the extent of violent behavior among persons with PTSD changes in response to intensive treatment or about the predictors and correlates of any such change. METHODS: The study examined data from over 35,000 U.S. military veterans treated in specialized intensive Veterans Health Administration PTSD programs...
December 15, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/29241428/state-targeted-funding-and-technical-assistance-to-increase-access-to-medication-treatment-for-opioid-use-disorder
#10
Amanda J Abraham, Christina M Andrews, Colleen M Grogan, Harold A Pollack, Thomas D'Aunno, Keith Humphreys, Peter D Friedmann
OBJECTIVE: As the United States grapples with an opioid epidemic, expanding access to effective treatment for opioid use disorder is a major public health priority. Identifying effective policy tools that can be used to expand access to care is critically important. This article examines the relationship between state-targeted funding and technical assistance and adoption of three medications for treating opioid use disorder: oral naltrexone, injectable naltrexone, and buprenorphine. METHODS: This study draws from the 2013-2014 wave of the National Drug Abuse Treatment System Survey, a nationally representative, longitudinal study of substance use disorder treatment programs...
December 15, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/29241406/outpatient-clinics-treating-substance-use-disorders-in-northwest-russia-and-northern-norway-a-descriptive-comparative-study
#11
Helene Marie Dahl, Grigory Rezvyy, Anatoly Bogdanov, Terje Øiesvold
Both in Norway and Russia a considerable portion of the population have substance use disorders. However, the knowledge about outpatient services treating substance use disorders in Norway and Russia is limited. This study will describe and compare outpatient clinics treating substance use disorders in Arkhangelsk in Northwest Russia and in Bodø and Tromsø in Northern Norway on availability, accessibility and treated prevalence (patients treated in one year). The managers (N=3) of the outpatient clinics (N=3) were interviewed with the European Service Mapping Schedule (ESMS) and the International Classification of Mental Health Care (ICMHC)...
2017: International Journal of Circumpolar Health
https://www.readbyqxmd.com/read/29241365/gabapentin-for-the-treatment-of-alcohol-use-disorder
#12
Barbara J Mason, Susan Quello, Farhad Shadan
Alcohol misuse is the fifth leading risk factor for premature death and disability worldwide. Fewer than 10% of afflicted Americans receive pharmacological treatment for alcohol use disorder. Gabapentin is a calcium channel GABAergic modulator that is widely used for pain. Studies showing reduced drinking and decreased craving and alcohol-related disturbances in sleep and affect in the months following alcohol cessation suggest therapeutic potential for alcohol use disorder. Areas covered: Human laboratory and clinical studies assessing gabapentin for alcohol use disorder are reviewed...
December 15, 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/29241104/the-relationship-between-self-compassion-and-the-risk-for-substance-use-disorder
#13
Cynthia L Phelps, Samantha M Paniagua, Irmgard U Willcockson, Jennifer S Potter
OBJECTIVE: This study explored the relationship between substance use disorder risk and self-compassion and posits a model for how the two are related through the mitigation of suffering. METHOD: Study participants were recruited using social media to complete an online survey that included a basic socio-demographic survey and two validated instruments, the Self-Compassion Survey and the National Institute on Drug Abuse (NIDA) Alcohol Smoking and Substance Involvement Screening Test (ASSIST), which screens for substance use disorder (SUD) risk...
December 8, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29241081/does-misuse-lead-to-a-disorder-the-misuse-of-prescription-tranquilizer-and-sedative-medications-and-subsequent-substance-use-disorders-in-a-u-s-longitudinal-sample
#14
C J Boyd, B West, S E McCabe
OBJECTIVES: We used two waves of National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) data and examined whether the misuse of prescription tranquilizers or sedatives at Wave 1 was associated with either continued misuse, tranquilizer/sedative use disorder, or other substance use disorder (SUD) at Wave 2. METHODS: Prospective data were analyzed from structured diagnostic interviews using the Alcohol Use disorders and Associated Disabilities Interview Schedule: DSM-IV Version (AUDADIS-DSM-IV)...
November 28, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29240853/the-evaluation-of-medical-inpatients-who-are-admitted-on-long-term-opioid-therapy-for-chronic-pain
#15
Hilary Mosher, Shoshana J Herzig, Itai Danovitch, Christina Boutsicaris, Sameer Hassamal, Karl Wittnebel, Azadeh Dashti, Teryl Nuckols
Individuals who are on long-term opioid therapy (LTOT) for chronic noncancer pain are frequently admitted to the hospital with acute pain, exacerbations of chronic pain, or comorbidities. Consequently, hospitalists find themselves faced with complex treatment decisions in the context of uncertainty about the effectiveness of LTOT as well as concerns about risks of overdose, opioid use disorders, and adverse events. Our multidisciplinary team sought to synthesize guideline recommendations and primary literature relevant to assessing medical inpatients on LTOT, with the objective of assisting practitioners in balancing effective pain treatment and opioid risk reduction...
December 6, 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/29238825/association-of-cumulative-childhood-adversity-and-adolescent-violent-offending-with-suicide-in-early-adulthood
#16
Emma Björkenstam, Anders Hjern, Charlotte Björkenstam, Kyriaki Kosidou
Importance: Childhood adversity (CA) is associated with an increased risk of suicide in young adulthood that might be explained by maladaptive trajectories during adolescence. Although adolescent violent offending is linked with suicide, little is known about its role in the association between CA and suicide. Objective: To examine whether adolescent violent offending mediates the association between CA and suicide in early adulthood. Design, Setting, and Participants: This population-based, longitudinal cohort study with a follow-up time spanning 5 to 9 years included 476 103 individuals born in Sweden between 1984 and 1988...
December 13, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29238320/understanding-appearance-enhancing-drug-use-in-sport-using-an-enactive-approach-to-body-image
#17
Denis Hauw, Jean Bilard
From an enactive approach to human activity, we suggest that the use of appearance-enhancing drugs is better explained by the sense-making related to body image rather than the cognitive evaluation of social norms about appearance and consequent psychopathology-oriented approach. After reviewing the main psychological disorders thought to link body image issues to the use of appearance-enhancing substances, we sketch a flexible, dynamic and embedded account of body image defined as the individual's propensity to act and experience in specific situations...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29238271/dual-depression-a-sex-perspective
#18
Adriana Farré, Judit Tirado-Muñoz, Marta Torrens
Mood and substance use disorders (SUDs) are mental conditions that are highly prevalent in the general population. Cooccurrence of major depression and SUD, also known as dual depression, is very common in the field of substance addiction. Sex differences are found in both major depression and SUD. This review, after presenting the state of the art of dual depression as regards prevalence, ethiopathologic mechanisms, and clinical aspects, is focused on dual depression in women. An overview of some potential factors associated with the sex gap in dual depression such as injecting, sexual risk behavior, intimate partner violence, and the reproductive cycle is presented...
December 2017: Addictive Disorders & Their Treatment
https://www.readbyqxmd.com/read/29238228/prenatal-exposure-to-antipsychotic-medication-and-use-of-primary-health-care-system-in-childhood-a-population-based-cohort-study-in-denmark
#19
Anne Mette Lund Würtz, Claus Høstrup Vestergaard, Dorte Rytter, Merete Juul Sørensen, Jakob Christensen, Mogens Vestergaard, Bodil Hammer Bech
Background: Antipsychotic (AP) medication is increasingly used for many health conditions. Prenatal exposure to AP medication has been associated with several adverse outcomes, but the findings remain inconsistent. Purpose: We aimed to investigate prenatal exposure to AP medication and the use of primary health care system in childhood. Subjects and methods: All live-born singletons in Denmark during 1997-2012 were identified in the nationwide Danish National Patient Register and followed until December 31, 2013 (n = 963,010)...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/29237425/german-general-practitioners-self-reported-management-of-patients-with-chronic-depression
#20
Florian Wolf, Antje Freytag, Sven Schulz, Thomas Lehmann, Susann Schaffer, Horst Christian Vollmar, Thomas Kühlein, Jochen Gensichen
BACKGROUND: Patients with chronic depression (persisting symptoms for ≥2 years) are a clinically relevant group with extensive (co)morbidity, high functional impairment and associated costs in primary care. The General Practitioner (GP) is the main health professional attending to these patients. The aim of this study was to examine the GPs' perception on managing patients with chronic depression. METHODS: We performed an explorative cross-sectional study with a systematic sample of GPs in central Germany...
December 13, 2017: BMC Psychiatry
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