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https://www.readbyqxmd.com/read/28447222/feeding-strategies-in-pediatric-cancer-patients-with-gastrointestinal-mucositis-a-multicenter-prospective-observational-study-and-international-survey
#1
Nicoline S S Kuiken, Edmond H H M Rings, Marry M van den Heuvel-Eibrink, Marianne D van de Wetering, Wim J E Tissing
INTRODUCTION: Currently, there is no adequate prevention or treatment for both oral and gastrointestinal mucositis induced by chemotherapy and/or radiotherapy. Supportive care of symptoms plays a primary role during mucositis in the pediatric clinical setting. We aimed to get insight in the currently used feeding strategies in clinical practice in pediatric cancer patients with chemotherapy-induced mucositis. METHODS: A prospective observational study was performed to identify feeding strategies after chemotherapy courses causing mucositis in almost all patients at the University Medical Center Groningen (UMCG), the Academic Medical Center Amsterdam (AMC), and the Princess Maxima Center Utrecht (PMC)...
April 26, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28446291/-clinical-significance-of-detecting-cd4-t-cells-in-peripheral-blood-of-patients-with-follicular-lymphoma
#2
Wei Liu, Guo-Xiang Zhagn, Wen-Zhi Shi, Lu Dong, Hua Liu, Xu-Liang Shen
OBJECTIVE: To investigate the changes of CD4(+) T lymphocytes in peripheral blood of patients with follicular lymphoma and its clinical significance. METHODS: Blood samples were collected for detection of whole blood cells, including absolute monocyte count (AMC), absolute lymphocyte count (ALC), hemoglobin (Hb), platelet count (Plt). Age, sex, pathological grade, number of involved lymph nodes, bone marrow involvement (BMI), Ann Arbor stage, B symptoms, serum lactate dehydrogenase (LDH) and serum β-2 microglobulin (β2-MG) were recorded, the prognostic stratification was performed by using FLIPI and FLIPI-2...
April 2017: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/28442255/acetanilide-and-bromoacetyl-lysine-derivatives-as-activators-for-human-histone-deacetylase-8
#3
Yusif M Mukhtar, Yajun Huang, Jiajia Liu, Di Chen, Weiping Zheng
In the current study, seven compounds (i.e. 1-7) were found to be novel activators for the N(ε)-acetyl-lysine deacetylation reaction catalyzed by human histone deacetylase 8 (HDAC8). When assessed with the commercially available HDAC8 peptide substrate Fluor-de-Lys®-HDAC8 that harbors the unnatural 7-amino-4-methylcoumarin (AMC) residue immediately C-terminal to the N(ε)-acetyl-lysine residue to be deacetylated, our compounds exhibited comparable activation potency to that of TM-2-51, the strongest HDAC8 activator reported in the current literature...
April 13, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28441676/transitioning-from-volume-to-value-one-academic-medical-center-s-approach-to-improving-population-health
#4
Stephanie A C Halvorson, Mary E Tanski, Thomas R Yackel
PROBLEM: The U.S. health care system is undergoing a major transformation. Clinical delivery systems are now being paid according to the value of the care they provide, in accordance with the Triple Aim, which incorporates improving the quality and cost of care and the patient experience. Increasingly, financial risk is being transferred from insurers to clinical delivery systems that become responsible for both episode-based clinical care and the longitudinal care of patients. Thus, these delivery systems need to develop strategies to manage the health of populations...
May 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28435146/prognostic-analysis-of-absolute-lymphocyte-and-monocyte-counts-after-autologous-stem-cell-transplant-in-children-adolescents-and-young-adults-with-refractory-or-relapsed-hodgkin-s-lymphoma
#5
Jorge Galvez Silva, Ossama M Maher, Minjeong Park, Diane Liu, Fiorela Hernandez, Priti Tewari, Yago Nieto
Previous studies in adults have shown that peripheral blood absolute lymphocyte and monocyte count ratio (ALC/AMC) after autologous stem cell transplant (ASCT) can predict outcome in patients with relapsed/refractory Hodgkin's lymphoma (R/R HL). We retrospectively reviewed all of our children, adolescent, and young adult (CAYA) patients (age ≤26) transplanted for R/R HL between 2004 and 2015. Seventy-six patients (median age 21, range 10-26 years) who reached d100 (d100) disease free were analyzed; 33% of them had PET-positive tumors prior to ASCT...
April 20, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28423163/metafrontier-frameworks-for-studying-hospital-productivity-growth-and-quality-changes
#6
Kuan-Chen Chen, Li-Nien Chien, Yi-Hsin Hsu, Ming-Miin Yu
Objective: The objective of this study was to evaluate productivity growth and quality changes among different levels of accredited hospitals. Design: This study used an attribute-incorporating Malmquist productivity index (MPI) under the metafrontier framework. This is the first attempt to compare productivity changes among hospitals operating under different production frontiers. Participants: The data consisted of 20 academic medical centers (AMCs), 61 metropolitan hospitals (MPs) and 112 local community hospitals (LCs) in Taiwan during the period 2007-2010...
December 1, 2016: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/28420766/project-accrue-exploring-options-to-increase-awareness-of-aids-malignancy-consortium-clinical-trials-in-north-carolina
#7
Anissa I Vines, Cathy L Melvin, Jaimie C Hunter, Veronica A Carlisle
BACKGROUND Longer lifespans conferred by antiretroviral therapy result in more time exposed to cancer risk for people living with HIV/AIDS (PLWHA). Given limited diversity in AIDS Malignancy Consortium (AMC) clinical trials, there is need for new approaches to educate PLWHA in order to improve awareness and participation in AMC trials.METHODS With input from a community advisory board, Project ACCRUE (AMC Clinical Trials at Carolina Ramp Up Enrollment) conducted a key informant interview with service providers; online organizational surveys of AMC trial awareness and resource needs; and "lunch and learn" educational sessions, including pre- and post-intervention knowledge assessments...
March 2017: North Carolina Medical Journal
https://www.readbyqxmd.com/read/28404093/somatic-pole-proofreading-domain-mutation-immune-response-and-prognosis-in-colorectal-cancer-a-retrospective-pooled-biomarker-study
#8
Enric Domingo, Luke Freeman-Mills, Emily Rayner, Mark Glaire, Sarah Briggs, Louis Vermeulen, Evelyn Fessler, Jan Paul Medema, Arnoud Boot, Hans Morreau, Tom van Wezel, Gerrit-Jan Liefers, Ragnhild A Lothe, Stine A Danielsen, Anita Sveen, Arild Nesbakken, Inti Zlobec, Alessandro Lugli, Viktor H Koelzer, Martin D Berger, Sergi Castellví-Bel, Jenifer Muñoz, Marco de Bruyn, Hans W Nijman, Marco Novelli, Kay Lawson, Dahmane Oukrif, Eleni Frangou, Peter Dutton, Sabine Tejpar, Mauro Delorenzi, Rachel Kerr, David Kerr, Ian Tomlinson, David N Church
BACKGROUND: Precision cancer medicine depends on defining distinct tumour subgroups using biomarkers that may occur at very modest frequencies. One such subgroup comprises patients with exceptionally mutated (ultramutated) cancers caused by mutations that impair DNA polymerase epsilon (POLE) proofreading. METHODS: We examined the association of POLE proofreading domain mutation with clinicopathological variables and immune response in colorectal cancers from clinical trials (VICTOR, QUASAR2, and PETACC-3) and colorectal cancer cohorts (Leiden University Medical Centre 1 and 2, Oslo 1 and 2, Bern, AMC-AJCC-II, and Epicolon-1)...
November 2016: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28398972/effectiveness-of-amylmetacresol-and-2-4-dichlorobenzyl-alcohol-throat-lozenges-in-patients-with-acute-sore-throat-due-to-upper-respiratory-tract-infection-a-systematic-review-protocol
#9
Ting W Tan, Bi C Chen, Han L Tan, Chih M Chang
This review aims to determine the best available evidence related to the effectiveness of amylmetacresol and 2,4-dichlorobenzyl alcohol throat lozenges in patients with acute sore throat due to upper respiratory tract infection (URTI). The objective is to examine the analgesic properties of amylmetacresol and 2,4-dichlorobenzyl alcohol (AMC/DCBA) throat lozenge comparing with placebo for the relief of pain in patients with acute sore throat due to URTIs.The review question is:More specifically, the objectives are to...
April 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28384388/targeted-synthesis-of-ultrastable-high-silica-rho-zeolite-through-alkali-metal-crown-ether-interaction
#10
Quanli Ke, Tianjun Sun, Hao Cheng, Haijun Chen, Xiaowei Liu, Xiaoli Wei, Shu-Dong Wang
High-silica RHO zeolite was directly synthesized using an alkali metal-crown ether (AMCE) complex as organic structure-directing agent (OSDA). Derived from the UV-vis spectra and zeolite patterns, the crown ether-cesium cation interaction was found to have crucial effect on the enhancement of silica content within the zeolite framework. The synthesized RHO zeolites possess up to four times larger silica/alumina ratio (SAR) values than that in their conventional form, which gives them extraordinarily rigid frameworks even after hydrothermal aging under 800℃...
April 6, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28383112/associations-between-elevated-pre-treatment-serum-cytokines-and-peripheral-blood-cellular-markers-of-immunosuppression-in-patients-with-lymphoma
#11
Moritz Binder, Megan M O'Byrne, Matthew J Maurer, Stephen Ansell, Andrew L Feldman, James Cerhan, Anne Novak, Luis Francisco Porrata, Svetomir Markovic, Brian K Link, Thomas E Witzig
Higher ratios of the pre-treatment peripheral blood absolute lymphocyte (ALC) to absolute monocyte counts (AMC) are associated with improved outcomes in lymphoma. Conversely, elevated pre-treatment serum cytokines are associated with inferior outcomes. The relationship between pre-treatment serum cytokines and ALC/AMC ratios remains unknown. We studied twelve serum cytokines and the ALC/AMC ratios in 390 patients with untreated diffuse large B-cell, follicular, mantle cell, T-cell, and Hodgkin lymphoma. Different pre-treatment serum cytokine concentrations correlated with ALC, AMC, and ALC/AMC ratios depending on the lymphoma type...
April 6, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28374968/long-term-functional-and-mobility-outcomes-for-individuals-with-arthrogryposis-multiplex-congenita
#12
Hirmand Nouraei, Bonita Sawatzky, Megan MacGillivray, Judith Hall
Arthrogryposis multiplex congenita (AMC) is a birth defect that involves congenital joint contractures in two or more joints including the limbs, spine, and jaw. The purpose of our study was to identify long-term outcomes of adults with AMC. We recruited 177 participants from over 15 countries, making this the largest international study of adults with AMC. Participants provided demographic information including living situation and mobility and completed two standardized outcome measures, of quality of life and physical activity, using an online survey format...
April 4, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28374019/cntnap1-mutations-cause-cns-hypomyelination-and-neuropathy-with-or-without-arthrogryposis
#13
Holger Hengel, Alex Magee, Muhammad Mahanjah, Jean-Michel Vallat, Robert Ouvrier, Mohammad Abu-Rashid, Jamal Mahamid, Rebecca Schüle, Martin Schulze, Ingeborg Krägeloh-Mann, Peter Bauer, Stephan Züchner, Rajech Sharkia, Ludger Schöls
OBJECTIVE: To explore the phenotypic spectrum and pathophysiology of human disease deriving from mutations in the CNTNAP1 gene. METHODS: In a field study on consanguineous Palestinian families, we identified 3 patients carrying homozygous mutations in the CNTNAP1 gene using whole-exome sequencing. An unrelated Irish family was detected by screening the GENESIS database for further CNTNAP1 mutations. Neurophysiology, MRI, and nerve biopsy including electron microscopy were performed for deep phenotyping...
April 2017: Neurology. Genetics
https://www.readbyqxmd.com/read/28370365/monocytosis-in-polycythemia-vera-clinical-and-molecular-correlates
#14
Daniela Barraco, Sonia Cerquozzi, Naseema Gangat, Mrinal M Patnaik, Terra Lasho, Christy Finke, Curtis A Hanson, Rhett P Ketterling, Animesh Pardanani, Ayalew Tefferi
Monocytosis (absolute monocyte count, AMC ≥1 x 10(9) /L) might accompany a spectrum of myeloid neoplasms, other than chronic myelomonocytic leukemia (CMML). In the current study, we examined the prevalence, laboratory and molecular correlates, and prognostic relevance of monocytosis in polycythemia vera (PV). Among 267 consecutive patients with World Health Organization (WHO)-defined PV, 55 (21%) patients displayed an AMC of ≥1 x 10(9) /L and 18 (7%) an AMC of ≥1.5 x 10(9) /L. In general, PV patients with monocytosis were significantly older and displayed higher frequencies of leukocytosis (81% vs 50% at AMC ≥1 x 10(9) /L) and TET2/SRSF2 mutations (57%/29% vs 19%/1% at AMC≥1...
March 28, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28368388/methylation-of-wnt-target-genes-axin2-and-dkk1-as-robust-biomarkers-for-recurrence-prediction-in-stage-ii-colon-cancer
#15
R Kandimalla, J F Linnekamp, S van Hooff, A Castells, X Llor, M Andreu, R Jover, A Goel, J P Medema
Stage II colon cancer (CC) still remains a clinical challenge with patient stratification for adjuvant therapy (AT) largely relying on clinical parameters. Prognostic biomarkers are urgently needed for better stratification. Previously, we have shown that WNT target genes AXIN2, DKK1, APCDD1, ASCL2 and LGR5 are silenced by DNA methylation and could serve as prognostic markers in stage II CC patients using methylation-specific PCR. Here, we have extended our discovery cohort AMC90-AJCC-II (N=65) and methylation was analyzed by quantitative pyrosequencing...
April 3, 2017: Oncogenesis
https://www.readbyqxmd.com/read/28362440/prognostic-relevance-of-lymphocytopenia-monocytopenia-and-lymphocyte-to-monocyte-ratio-in-primary-myelodysplastic-syndromes-a-single-center-experience-in-889-patients
#16
L Saeed, M M Patnaik, K H Begna, A Al-Kali, M R Litzow, C A Hanson, R P Ketterling, L F Porrata, A Pardanani, N Gangat, A Tefferi
Current prognostic models for myelodysplastic syndromes (MDS), including the Revised International Prognostic Scoring System (IPSS-R), do not account for host immunity. We retrospectively examined the prognostic relevance of monocytopenia, lymphocytopenia and lymphocyte-to-monocyte ratio (LMR) in a cohort of 889 patients with primary MDS. After a median follow-up of 27 months, 712 (80%) deaths and 116 (13%) leukemic transformation were documented. In univariate analysis, subnormal absolute lymphocyte count (ALC) <0...
March 31, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28350314/integrating-quality-improvement-and-continuing-professional-development-at-an-academic-medical-center-a-partnership-between-practice-plan-hospital-and-medical-school
#17
Barbara Gold, Dawn England, William Riley, Ginny Jacobs-Halsey, Corinne Webb, Bobbi Daniels
INTRODUCTION: While quality improvement (QI) initiatives can be a highly effective means for improving health care delivery in academic medical centers (AMCs), many health care professionals are not formally trained in basic QI methodology, engaging clinicians in QI activities can be challenging, and there is often a lack of integration and coordination among QI functions (eg, Departments of Quality and Safety, Continuing Professional Development). In our AMC, we undertook a collaborative approach to achieve better vertical and horizontal integration of our QI education efforts...
October 2016: Journal of Continuing Education in the Health Professions
https://www.readbyqxmd.com/read/28347532/lobectomy-for-lung-cancer-at-veterans-administration-medical-center-versus-academic-medical-center
#18
Travis Geraci, Vanessa Baratta, John Young, Steven Milman, Ann-Marie Dunican, Richard N Jones, Thomas Ng
BACKGROUND: Hospital and surgeon volume each have an association with postoperative outcomes. The volume of lung cancer surgery at our Veterans Administration Medical Center (VAMC) is lower than at our academic medical center (AMC). We compared the outcomes after lobectomy at VAMC versus AMC to identify specific areas of clinical care requiring quality improvement. METHODS: To keep surgeon experience constant, data were derived from a prospective database from a single surgeon...
March 24, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28344185/arthrogryposis-as-neonatal-presentation-of-loeys-dietz-syndrome-due-to-a-novel-tgfbr2-mutation
#19
Irene Valenzuela, Paula Fernández-Alvarez, Francina Munell, Angel Sanchez-Montanez, Gemma Giralt, Teresa Vendrell, Eduardo Tizzano
Loeys-Dietz syndrome (LDS) is an autosomal dominant connective tissue disorder characterized mainly by cardiovascular, craniofacial and skeletal features. We report on a patient with LDS, whose prenatal examination was compatible with the diagnosis of arthrogryposis multiplex congenita. Neonatal assessment showed craniofacial and cardiovascular findings suggestive of LDS whose diagnosis was confirmed by the detection of a novel mutation (HGVN: NM_003242.5 (TGFBR2): c.1381T > C (p.(Cys461Arg))) in the TGFBR2 gene...
March 23, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/28329731/feasibility-toxicity-and-response-of-upfront-metaiodobenzylguanidine-therapy-therapy-followed-by-german-pediatric-oncology-group-neuroblastoma-2004-protocol-in-newly-diagnosed-stage-4-neuroblastoma-patients
#20
K C J M Kraal, G M Bleeker, B L F van Eck-Smit, N K A van Eijkelenburg, F Berthold, M M van Noesel, H N Caron, G A M Tytgat
AIM OF THE STUDY: Radiolabelled meta-iodobenzylguanidine (MIBG) is an effective option in treatment of neuroblastoma (NBL) tumours. We studied feasibility, toxicity and efficacy of upfront (131)I-MIBG and induction treatment in stage 4 NBL patients. PATIENTS AND METHODS: Retrospective, multi-centre (AMC and EMC) pilot regimen (1/1/2005-2011). Newly diagnosed stage 4 NBL patients, were treated with 2 courses of (131)I-MIBG, GPOH 2004 NBL protocol, myeloablative therapy (MAT) and autologous stem cell rescue (ASCT)...
March 19, 2017: European Journal of Cancer
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