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https://www.readbyqxmd.com/read/28716427/influence-of-l-dopa-on-subtle-motor-signs-in-heterozygous-parkin-and-pink1-mutation-carriers
#1
Anne Weissbach, Inke R König, Katja Hückelheim, Peter P Pramstaller, Elisa Werner, Norbert Brüggemann, Vera Tadic, Katja Lohmann, Tobias Bäumer, Alexander Münchau, Meike Kasten, Christine Klein
INTRODUCTION: A latent nigrostriatal deficit and its possible clinical consequences in asymptomatic heterozygous Parkin and PINK1 mutation carriers (AMC) have been a matter of investigation in recent years. Notably, mild Parkinsonian signs in heterozygous mutation carriers can be so subtle that they may be missed if not specifically investigated. METHODS: We studied 15 heterozygous Parkin and PINK1 AMC and 18 age- and sex-matched mutation-negative controls using a standardized video, instructing the probands to perform relevant parts of the UPDRS III to investigate fine motor movements at baseline and after first-time L-Dopa administration...
July 8, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28676467/the-rules-of-engagement-perspectives-on-secure-messaging-from-experienced-ambulatory-patient-portal-users
#2
Cynthia J Sieck, Jennifer L Hefner, Jeanette Schnierle, Hannah Florian, Aradhna Agarwal, Kristen Rundell, Ann Scheck McAlearney
BACKGROUND: Patient portals have shown promise in engaging individuals in self-management of chronic conditions by allowing patients to input and track health information and exchange secure electronic messages with their providers. Past studies have identified patient barriers to portal use including usability issues, low health literacy, and concerns about loss of personal contact as well as provider concerns such as increased time spent responding to messages. However, to date, studies of both patient and provider perspectives on portal use have focused on the pre-implementation or initial implementation phases and do not consider how these issues may change as patients and providers gain greater experience with portals...
July 4, 2017: JMIR Medical Informatics
https://www.readbyqxmd.com/read/28665841/asymmetric-multisutural-craniosynostosis-an-algorithm-of-early-intervention-to-prevent-evolving-deformity
#3
Michael R Bykowski, Sanjay Naran, Renata Maricevich, Jesse A Goldstein, Joseph E Losee
BACKGROUND: Asymmetric multisutural craniosynostosis (AMC) is characterized by fusion of a midline suture combined with unilateral fusion of at least 1 nonmidline suture. Due to its rarity, complexity, and high rate of reoperation, the purpose of this study is to evaluate outcomes of our staged approach to AMC. METHODS: Patients treated for craniosynostosis between January 2004 and December 2013 were identified retrospectively. Only patients with AMC and a minimum follow-up of 2 years were included...
June 29, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28664876/scaling-up-of-a-heparg-progenitor-cell-based-bioartificial-liver-optimization-for-clinical-application-and-transport
#4
Martien van Wenum, Philipp Treskes, Chung-Yin Tang, Esmee J Coppens, Koen Jansen, Erik J Hendriks, Sandrine Camus, Thomas M van Gulik, Robert A F M Chamuleau, Ruurdtje Hoekstra
A new generation of bioartificial livers, based on differentiated proliferative hepatocyte sources, has been developed. Several practicable and regulatory demands have to be addressed before these can be clinically evaluated. We identified three main hurdles: (1) expansion and preservation of the biocomponent, (2) development of scaled-up culture conditions and (3) transport of the device to the bedside. In this study we address these three issues for the HepaRG-progenitor cell line-loaded AMC-Bioartificial Liver...
June 30, 2017: Biofabrication
https://www.readbyqxmd.com/read/28656258/cip2a-an-oncoprotein-is-associated-with-cell-proliferation-invasion-and-migration-in-laryngeal-carcinoma-cells
#5
Xu-Dong Chen, Shi-Xiong Tang, Jian-Hua Zhang, Li-Tao Zhang, Yao-Wen Wang
Laryngeal carcinoma is one of the most common malignant tumors in otorhinolaryngology. Moreover, experimental investigation showed that cancerous inhibitor of protein phosphatase 2A (CIP2A) expressed highly in various cancers. Therefore, we investigated whether CIP2A can regulate the proliferation, invasion and migration by RNA interference in Hep-2 cells and AMC-NH-8 cells and further affect the activation of phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) pathway. Overexpression of CIP2A was evaluated in tumor tissue and laryngeal cancer cell lines (Hep-2 and AMC-NH-8 cells) by real-time quantitative polymerase chain reaction (RT-qPCR) and western blot assay...
June 27, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28633176/determinants-of-the-5-year-retention-and-rural-location-of-family-physicians-results-from-the-iowa-family-medicine-training-network
#6
Gregory C Nelson, Thomas S Gruca
BACKGROUND AND OBJECTIVES: States are seeking ways to retain primary care physicians trained within their borders. We analyzed the 5-year retention and rural Iowa location decisions for 1,645 graduates of the Iowa Family Medicine Training Network (IFMTN)-eight residency programs (in seven different cities) that are affiliated with the Carver College of Medicine (University of Iowa). METHODS: Data from 1977-2014 includes 98.5% of active graduates. Location in Iowa 5 years after graduation was the dependent variable in a binary logistic regression...
June 2017: Family Medicine
https://www.readbyqxmd.com/read/28607939/the-role-of-the-peripheral-passive-rotation-stabilizers-of-the-knee-with-intact-collateral-and-cruciate-ligaments-a-biomechanical-study
#7
Alexander R Vap, Jason M Schon, Gilbert Moatshe, Raphael S Cruz, Alex W Brady, Grant J Dornan, Travis Lee Turnbull, Robert F LaPrade
BACKGROUND: A subset of patients have clinical internal and/or external knee rotational instability despite no apparent injury to the cruciate or collateral ligaments. PURPOSE/HYPOTHESIS: The purpose of this study was to assess the effect of sequentially cutting the posterolateral, anterolateral, posteromedial, and anteromedial structures of the knee on rotational stability in the setting of intact cruciate and collateral ligaments. It was hypothesized that cutting of the iliotibial band (ITB), anterolateral ligament and lateral capsule (ALL/LC), posterior oblique ligament (POL), and posteromedial capsule (PMC) would significantly increase internal rotation, while sectioning of the anteromedial capsule (AMC) and the popliteus tendon and popliteofibular ligament (PLT/PFL) would lead to a significant increase in external knee rotation...
May 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28605402/sparse-redundancy-analysis-of-high-dimensional-genetic-and-genomic-data
#8
Attila Csala, Frans P J M Voorbraak, Aeilko H Zwinderman, Michel H Hof
Motivation: Recent technological developments have enabled the possibility of genetic and genomic integrated data analysis approaches, where multiple omics data sets from various biological levels are combined and used to describe (disease) phenotypic variations. The main goal is to explain and ultimately predict phenotypic variations by understanding their genetic basis and the interaction of the associated genetic factors. Therefore, understanding the underlying geneticmechanisms of phenotypic variations is an ever increasing research interest in biomedical sciences...
June 12, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28600099/integrating-interventional-cardiology-and-heart-failure-management-for-cardiogenic-shock
#9
REVIEW
Navin K Kapur, Carlos D Davila, Marwan F Jumean
Cardiogenic shock remains one of the most common causes of in-hospital death. Recent data have identified an overall increase in patient complexity, with cardiogenic shock in the setting of acute myocardial infarction. The use of percutaneous acute mechanical circulatory support (AMCS) has steadily grown in the past decade. Guidelines and consensus statements addressing proper patient selection, timing of AMCS implantation, device choice, and postimplantation protocol are appearing. The emerging role of interventional heart failure specialists within the heart team includes integration and understanding of advanced hemodynamic and cathether-based therapies, with the goal of improving outcomes...
July 2017: Interventional cardiology clinics
https://www.readbyqxmd.com/read/28594692/adults-living-with-amyoplasia-function-psychosocial-aspects-and-the-benefit-of-amc-support-groups
#10
Unni Steen, Elise Christensen, Ani Samargian
Little is known about how adults manage living with amyoplasia. Two studies concerning adults with amyoplasia were conducted; a cross-sectional study and a qualitative study. The aims were to describe body functions, activity and participation, and to explore psychosocial dimensions. This article also emphasizes the importance of Patient Support Groups as arenas for sharing experience and gaining knowledge.
July 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28594689/treatment-of-scoliosis-associated-with-arthrogryposis-multiplex-congenita
#11
Igor Komolkin, Edvard V Ulrich, Olga E Agranovich, Harold J P van Bosse
Scoliosis in children with arthrogryposis occurs in the minority of patients, but appears early, often present at birth. Curves can progress quickly. Treatment options include spine casting, bracing, expandable implant surgery, and spinal fusion. The goal is to allow as much chest growth and development as possible, along with a resulting well-balanced spine.
July 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28594688/treatment-of-the-lower-extremity-contracture-deformities
#12
Harold J P van Bosse, Eva Pontén, Akifusa Wada, Olga E Agranovich, Bartłomiej Kowalczyk, Ehud Lebel, Hakan Şenaran, Denis V Derevianko, Maxim A Vavilov, Ekaterina V Petrova, Dmitry B Barsukov, Sergey F Batkin, Sharon Eylon, Vladimir M Kenis, Yulia V Stepanova, Dmitry S Buklaev, Guney Yilmaz, Oksana Köse, Svetlana I Trofimova, Fatih Durgut
Lower extremity deformities of patients with arthrogryposis multiplex congenita present a wide spectrum of severity and deformity combinations. Treatment goals range from merely ensuring comfortable seating and shoe wear, to fully independent and active ambulation, but the overarching intention is to help realize the patient's greatest potential for independence and function. Treatment of hip and knee contractures and dislocations has become more interventional, whereas treatment of foot deformities has paradoxically become much less surgical...
July 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28594687/treatment-of-the-upper-extremity-contracture-deformities
#13
Scott N Oishi, Olga Agranovich, Giorgio E Pajardi, Chiara Novelli, Alexey G Baindurashvili, Svetlana I Trofimova, Hisham Abdel-Ghani, Evgenia Kochenova, Giulietta Prosperpio, Andrea Jester, Güney Yilmaz, Hakan Şenaran, Oksana Kose, Lesley Butler
Patients with arthrogryposis multiplex congenita have a characteristic upper extremity resting posture consisting of internal rotation of the shoulders, elbow extension, flexed wrists, thumb-in palm deformities, and variable degrees of finger contractures. Treatment of these patients is aimed at improving independence and performance of activities of daily living. Although each area needs to be assessed independently for the most appropriate surgical procedure, often multiple areas can be addressed at the same operative setting...
July 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28594686/genetics-and-classifications
#14
Judith G Hall, Eva Kimber, Harold J P van Bosse
Arthrogryposis multiplex congenital (AMC) is a descriptive term for a group of conditions that all share the characteristic of congenital contractures. There are an estimated 400 discrete diagnoses that can lead to a child being born with arthrogryposis. The 2 biggest categories of conditions are amyoplasia and distal arthrogryposis, which combined make up ∼50% to 65% of all diagnoses within the AMC subset. Amyoplasia, the most common AMC condition, seems to be a nongenetic syndrome, leading to very characteristic upper and lower limb contractures...
July 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28582400/variations-in-survival-after-cardiac-arrest-among-academic-medical-center-affiliated-hospitals
#15
Michael Christopher Kurz, John P Donnelly, Henry E Wang
BACKGROUND: Variation exists in cardiac arrest (CA) survival among institutions. We sought to determine institutional-level characteristics of academic medical centers (AMCs) associated with CA survival. METHODS: We examined discharge data from AMCs participating with Vizient clinical database-resource manager. We identified cases using ICD-9 diagnosis code 427.5 (CA) or procedure code 99.60 (CPR). We estimated hospital-specific risk-standardized survival rates (RSSRs) using mixed effects logistic regression, adjusting for individual mortality risk...
2017: PloS One
https://www.readbyqxmd.com/read/28580136/acute-mechanical-circulatory-support-for-cardiogenic-shock-the-door-to-support-time
#16
REVIEW
Michele L Esposito, Navin K Kapur
Cardiogenic shock (CS) remains a major cause of in-hospital mortality in the setting of acute myocardial infarction. CS begins as a hemodynamic problem with impaired cardiac output leading to reduced systemic perfusion, increased residual volume within the left and right ventricles, and increased cardiac filling pressures. A critical step towards the development of future algorithms is a clear understanding of the treatment objectives for CS. In this review, we introduce the "door to support" time as an emerging target of therapy to improve outcomes associated with CS, define four key treatment objectives in the management of CS, discuss the importance of early hemodynamic assessment and appropriate selection of acute mechanical circulatory support (AMCS) devices for CS, and introduce a classification scheme that identifies subtypes of CS based on cardiac filling pressures...
2017: F1000Research
https://www.readbyqxmd.com/read/28571009/surgery-is-an-effective-option-after-failure-of-chemoradiation-in-cancers-of-the-anal-canal-and-anal-margin
#17
Jean-Baptiste Delhorme, François Severac, Waisse Waissi, Benoit Romain, Delphine Antoni, Kelle C Freel, Catherine Schumacher, Serge Rohr, Cécile Brigand, Georges Noël
BACKGROUND: Surgery for anal canal cancer (ACC) and anal margin cancer (AMC) is the only curative option after failure of chemoradiotherapy (CRT). This study aimed to determine the efficacy of surgery for ACC or AMC after failed CRT. METHODS: This was a single-centre, retrospective study of 161 patients initially treated with CRT. We compared the survival rates of patients successfully treated by CRT with those of patients whose CRT failed (both surgically salvaged and treated palliatively)...
June 2, 2017: Oncology
https://www.readbyqxmd.com/read/28567106/antenatal-ultrasonography-findings-and-magnetic-resonance-imaging-in-a-case-of-pena-shokeir-phenotype
#18
Xuan-Hong Tomai, Thanh-Xuan Jasmine, Thanh-Hai Phan
Pena-Shokeir phenotype is a lethal anomaly characterized by neurogenic arthrogryposis, craniofacial anomalies, and pulmonary hypoplasia. This syndrome should be distinguished from trisomy 18 and arthrogryposis multiplex congenita for better counseling and establishing fetal prognosis. We present the case of a pregnant woman diagnosed with a Pena-Shokeir phenotype affected fetus at 24 weeks of gestation. Prenatal ultrasonography and fetal magnetic resonance imaging detected persistent hyperextension of the lumbar spine, micrognathia, absent septum pellucidum, and all characteristic features of Pena-Shokeir phenotype...
May 2017: Ultrasound: Journal of the British Medical Ultrasound Society
https://www.readbyqxmd.com/read/28562453/continuing-professional-development-for-faculty-an-elephant-in-the-house-of-academic-medicine-or-the-key-to-future-success
#19
David A Davis, William F Rayburn, Gary A Smith
The scope of change required by academic medical centers (AMCs) to maintain their viability and achieve their tripartite mission in the future is large; such reform is affected by numerous global, national, and local forces. Most AMCs focus their transformational efforts on organizational infrastructure (e.g., undertaking payment reform, developing new organizational structures, investing in information technology) and educational programs (with subsequent changes in undergraduate and graduate medical education curricula)...
May 30, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28561742/a-general-strategy-toward-graphitized-carbon-coating-on-iron-oxides-as-advanced-anodes-for-lithium-ion-batteries
#20
Chunyan Ding, Weiwei Zhou, Bin Wang, Xin Li, Dong Wang, Yong Zhang, Guangwu Wen
Integration of carbon materials with benign iron oxides blazes a way in constructing high-performance anodes for lithium-ion batteries (LIBs). In this paper, a unique general, simple, and controllable strategy is developed toward in-situ uniform coating of iron oxide nanostructures with graphitized carbon (GrC) layers. Basic synthetic procedure only involves a simple dip-coating process for the loading of Ni-containing seeds and a subsequent Ni-catalyzed chemical vapor deposition (CVD) process for the growth of GrC layers...
May 31, 2017: Nanotechnology
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