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https://www.readbyqxmd.com/read/28110458/experimental-evaluation-of-new-chitin-chitosan-graft-for-duraplasty
#1
M Pogorielov, A Kravtsova, G C Reilly, V Deineka, G Tetteh, O Kalinkevich, O Pogorielova, R Moskalenko, G Tkach
Natural materials such as collagen and alginate have promising applications as dural graft substitutes. These materials are able to restore the dural defect and create optimal conditions for the development of connective tissue at the site of injury. A promising material for biomedical applications is chitosan-a linear polysaccharide obtained by the deacetylation of chitin. It has been found to be nontoxic, biodegradable, biofunctional and biocompatible in addition to having antimicrobial characteristics. In this study we designed new chitin-chitosan substitutes for dura mater closure and evaluated their effectiveness and safety...
February 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28110416/lasiokaurin-derivatives-synthesis-antimicrobial-and-antitumor-biological-evaluation-and-apoptosis-inducing-effects
#2
Da-Hong Li, Ping Hu, Sheng-Tao Xu, Chun-Yan Fang, Shuang Tang, Xin-Yu Wang, Xing-Yan Sun, He Li, Ying Xu, Xiao-Ke Gu, Jin-Yi Xu
Herein, a series of lasiokaurin derivatives were designed and synthesized. All the derivatives together with lasiokaurin and oridonin were tested for their antimicrobial and antiproliferative activity. Compound 16 showed the most promising antimicrobial activity with MICs of 2.0 and 1.0 μg/mL against Gram-Positive bacteria S. aureus and B. subtilis, respectively. All the synthetic lasiokaurin derivatives showed better antiproliferative activity than parent compound lasiokaurin 1. Compound 10 exhibited the strongest cytotoxicity with IC50 values of 0...
January 21, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28110415/antimicrobial-combination-treatment-including-ciprofloxacin-decreased-the-mortality-rate-of-pseudomonas-aeruginosa-bacteraemia-a-retrospective-cohort-study
#3
M Paulsson, A Granrot, J Ahl, J Tham, F Resman, K Riesbeck, F Månsson
Ineffective antimicrobial therapy of Pseudomonas aeruginosa bacteraemia increases mortality. Recent studies have proposed the use of antimicrobial combination therapy composed of a beta-lactam with either ciprofloxacin or tobramycin. To determine if combination therapy correlates to lower mortality and is superior compared to monotherapy, we investigated the effect of antimicrobial treatment regimens on 30-day mortality in a cohort with Pseudomonas aeruginosa bacteraemia. All cases of P. aeruginosa bacteraemia (n = 292) in southwest Skåne County, Sweden (years 2005-2010, adult population 361,112) and the whole county (2011-2012, 966,130) were identified...
January 21, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28110121/s100a12-friend-or-foe-in-pulmonary-tuberculosis
#4
Vahid Bagheri
In humans, S100A12 (also named Calgranulin C and EN-RAGE) is mainly expressed and secreted by neutrophil granulocytes. Extracellular S100A12 is involved in innate immune responses against microorganisms and parasites. S100A12 is a ligand for the receptor for advanced glycation end products (RAGE), which is a cell surface receptor on macrophages, endothelium, and lymphocytes. In a recent study, Realegeno et al. showed that S100A12 exerts antimicrobial activity against Mycobacterium leprae in infected human macrophages...
January 18, 2017: Cytokine
https://www.readbyqxmd.com/read/28110048/ecotoxicology-of-glycerol-monolaurate-nanocapsules
#5
Leonardo Q S Lopes, Cayane G Santos, Rodrigo de Almeida Vaucher, Renata P Raffin, Aleksandro S da Silva, Dilmar Baretta, Ana Paula Maccari, Laura Caroline D D Giombelli, Andreia Volpato, Jessyka Arruda, Cecília de Ávila Scheeren, Bernardo Baldisserotto, Roberto C V Santos
Glycerol Monolaurate (GML) is a compound with known antimicrobial potential, however it is not much used due to its low solubility in water and high melting point. The nanoencapsulation of some drugs offers several advantages such as improved stability and solubility in water. The present study aimed to produce, characterize, and evaluate the ecotoxicity of GML nanocapsules. The nanocapsules were produced and presented a mean diameter of 210nm, polydispersity index of 0.044, and zeta potential of -23.4mV. The electron microscopy images showed the nanometric size and spherical shape...
January 19, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28110014/nanosilver-as-a-disinfectant-in-dental-unit-waterlines-assessment-of-the-physicochemical-transformations-of-the-agnps
#6
Alireza Gitipour, Souhail R Al-Abed, Stephen W Thiel, Kirk G Scheckel, Thabet Tolaymat
Dental unit water lines (DUWL) are susceptible to biofilm development and bacterial growth leading to water contamination, causing health and ecological effects. This study monitors the interactions between a commonly used nanosilver disinfectant (ASAP-AGX-32, an antimicrobial cleaner for dental units, 0.0032% Ag) and biofilm development in DUWL. To simulate the disinfection scenario, an in-house DUWL model was assembled and biofilm accumulation was allowed. Subsequent to biofilm development, the disinfection process was performed according to the manufacturer's instructions...
January 12, 2017: Chemosphere
https://www.readbyqxmd.com/read/28109846/antimicrobial-susceptibility-of-clinical-isolates-of-actinomyces-and-related-genera-reveals-an-unusual-clindamycin-resistance-among-actinomyces-urogenitalis-strains
#7
Claudia Barberis, Mabel Budia, Susana Palombarani, Carlos Hernán Rodriguez, María Soledad Ramírez, Barbara Arias, Laura Bonofiglio, Angela Famiglietti, Marta Mollerach, Marisa Almuzara, Carlos Vay
OBJECTIVES: Patterns of antimicrobial susceptibility in Actinomyces and related genera are very limited in the literature. Data of predominant susceptibility profiles could contribute to the establishment of an accurate empirical treatment. METHODS: A total of 113 isolates from clinical samples were included in this study. Each isolate was identified using phenotypic methods and MALDI-TOF/MS. When discrepancies were observed, 16S rRNA gene sequencing was performed...
January 18, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28109770/modulation-of-the-antibiotic-activity-against-multidrug-resistant-strains-of-coumarins-isolated-from-rutaceae-species
#8
Sara A L Madeiro, Nathalie H P B Borges, Augusto L Souto, Pedro T R de Figueiredo, José P Siqueira-Junior, Josean F Tavares
The first occurrences and dissemination of resistant microorganisms led to the inefficacy of many antibiotics, available in the market nowadays, therefore, the search for new substances with antimicrobial activity from natural sources has gained a great importance. The purpose of this work is to evaluate the antibacterial activity and modulation of drug resistance in Staphylococcus aureus by coumarins such as bergapten, xantotoxin, isopimpinellin and imperatorin obtained from two Rutaceae species (Metrodorea mollis and Pilocarpus spicatus)...
January 18, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28109692/-infectious-risk-related-to-the-formation-of-multi-species-biofilms-candida%C3%A2-%C3%A2-bacteria-on-peripheral-vascular-catheters
#9
REVIEW
A Seghir, Z Boucherit-Otmani, L Sari-Belkharroubi, K Boucherit
The Candida yeasts are the fourth leading cause of death from systemic infections, the risk may increase when the infection also involves bacteria. Yeasts and bacteria can adhere to medical implants, such as peripheral vascular catheters, and form a multicellular structures called "mixed biofilms" more resistant to antimicrobials agents. However, the formation of mixed biofilms on implants leads to long-term persistent infections because they can act as reservoirs of pathogens that have poorly understood interactions...
January 18, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28109595/pulsed-light-and-antimicrobial-combination-treatments-for-surface-decontamination-of-cheese-favorable-and-antagonistic-effects
#10
J Proulx, G Sullivan, L F Marostegan, S VanWees, L C Hsu, C I Moraru
Postprocessing cross-contamination of cheese can lead to both food safety issues and significant losses due to spoilage. Pulsed light (PL) treatment, consisting of short, high-energy, broad-spectrum light pulses, has been proven effective in reducing the microbial load on cheese surface. As PL treatment effectiveness is limited by light-cheese interactions, the possibility to improve its effectiveness by combining it with the antimicrobial nisin was explored. The effect of natamycin, which is added to cheeses as an antifungal agent, on PL effectiveness was also investigated...
January 18, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28109594/characteristics-of-resistance-and-virulence-factors-in-different-species-of-coagulase-negative-staphylococci-isolated-from-milk-of-healthy-sheep-and-animals-with-subclinical-mastitis
#11
Katheryne B Martins, Patricia Y Faccioli, Mariana F Bonesso, Simone Fernandes, Aline A Oliveira, Ariane Dantas, Luiz F Zafalon, Maria de Lourdes R S Cunha
Coagulase-negative staphylococci (CNS) are among the main responsible agents for mastitis in sheep. Cure rates can be reduced due to several causes, such as those related to virulence factors presented by microorganisms. This study aims at characterizing the virulence and resistance factors to antimicrobial agents in different CNS species isolated from sheep milk. After collecting milk samples, the samples were analyzed and the CNS species were identified. After identification, the susceptibility-sensitivity profile was examined using the disk diffusion technique for 10 antimicrobial agents...
January 18, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28109589/effects-of-precalving-body-condition-and-prepartum-feeding-level-on-gene-expression-in-circulating-neutrophils
#12
M A Crookenden, C G Walker, A Heiser, A Murray, V S R Dukkipati, J K Kay, S Meier, K M Moyes, M D Mitchell, J J Loor, J R Roche
Extensive metabolic, physiological, and immunological changes are associated with calving and the onset of lactation. As a result, cows transitioning between pregnancy and lactation are at a greater risk of metabolic and infectious diseases. The ability of neutrophils to mount an effective immune response to an infection is critical for its resolution, and increasing evidence indicates that precalving nutrition affects postpartum neutrophil function. The objectives of the current study were to investigate the effect of 2 precalving body condition scores (BCS; 4 vs...
January 18, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28109583/detection-of-recombinant-human-lactoferrin-and-lysozyme-produced-in-a-bitransgenic-cow
#13
Germán G Kaiser, Nicolás C Mucci, Vega González, Lourdes Sánchez, José A Parrón, María D Pérez, Miguel Calvo, Juan F Aller, Federico A Hozbor, Adrián A Mutto
Lactoferrin and lysozyme are 2 glycoproteins with great antimicrobial activity, being part of the nonspecific defensive system of human milk, though their use in commercial products is difficult because human milk is a limited source. Therefore, many investigations have been carried out to produce those proteins in biological systems, such as bacteria, yeasts, or plants. Mammals seem to be more suitable as expression systems for human proteins, however, especially for those that are glycosylated. In the present study, a bicistronic commercial vector containing a goat β-casein promoter and an internal ribosome entry site fragment between the human lactoferrin and human lysozyme genes was developed to allow the introduction of both genes into bovine adult fibroblasts in a single transfection...
January 18, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28109354/ureaplasma-transmitted-from-donor-lungs-is-pathogenic-after-lung-transplantation
#14
Ramiro Fernandez, Amy Ratliff, Donna Crabb, Ken B Waites, Ankit Bharat
Hyperammonemia is a highly fatal syndrome in lung recipients that is usually refractory to medical therapy. We recently reported that infection by a Mollicute, Ureaplasma, is causative for hyperammonemia and can be successfully treated with antimicrobial agents. However, it remains unknown whether the pathogenic strain of Ureaplasma is donor or recipient derived. Here we provide evidence that donor-derived Ureaplasma infection can be pathogenic. As such, we uncover a previously unknown lethal donor-derived opportunistic infection in lung recipients...
February 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28109195/fungal-periprosthetic-joint-infection-following-total-elbow-arthroplasty-a-case-report-and-review-of-the-literature
#15
Cory A Kwong, Shannon K T Puloski, Kevin A Hildebrand
BACKGROUND: With improving surgical techniques for total elbow arthroplasty clinical outcomes have improved and its utilization continues to increase. Despite these advances, complication rates remain as high as 24%. Of these complications periprosthetic joint infection is one of the most common and morbid. The rheumatoid elbow remains a leading indication for total elbow arthroplasty. Patients with this condition frequently require immunosuppressive therapy, which places them at higher risk of both typical and atypical infections...
January 21, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28109187/antimicrobial-and-antioxidant-activities-of-saccharomyces-cerevisiae-ifst062013-a-potential-probiotic
#16
Md Fakruddin, Md Nur Hossain, Monzur Morshed Ahmed
BACKGROUND: Probiotic yeast has become a field of interest to scientists in recent years. METHODS: Conventional cultural method was employed to isolate and identify yeast and standard methods were used to determine different probiotic attributes, antimicrobial and antioxidant properties. RESULTS: This study reports potential probiotic properties of a strain of S. cerevisiae IFST 062013 isolated from fruit. The isolate is tolerant to a wide range of temperature and pH, high concentration of bile salt and NaCl, gastric juice, intestinal environment, α-amylase, trypsin and lysozyme...
January 21, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28108717/one-health-perspective-of-antimicrobial-resistance
#17
Nancy De Briyne
No abstract text is available yet for this article.
January 21, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28108707/bcva-promotes-responsible-use-of-antimicrobials
#18
(no author information available yet)
No abstract text is available yet for this article.
January 21, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28108677/in-vitro-susceptibility-to-19-agents-other-than-%C3%AE-lactams-among-third-generation-cephalosporin-resistant-enterobacteriaceae-recovered-on-hospital-admission
#19
A Mischnik, P Baumert, A Hamprecht, A M Rohde, S Peter, S Feihl, J Knobloch, H Gölz, A Kola, B Obermann, C Querbach, M Willmann, F Gebhardt, E Tacconelli, P Gastmeier, H Seifert, W V Kern
OBJECTIVES: As part of the multicentre Antibiotic Therapy Optimisation Study, MIC values of 19 non-β-lactam agents were determined for third-generation cephalosporin-resistant Escherichia coli, Klebsiella species and Enterobacter species (3GCREB) isolates collected in German hospitals. METHODS: A total of 328 E. coli, 35 Klebsiella spp. (1 Klebsiella oxytoca and 34 Klebsiella pneumoniae) and 16 Enterobacter spp. (1 Enterobacter aerogenes and 15 Enterobacter cloacae) isolates were submitted to broth microdilution antimicrobial susceptibility testing with the MICRONAUT system...
January 19, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28108362/an-in-vitro-study-on-the-burn-wound-healing-activity-of-cotton-fabrics-incorporated-with-phytosynthesized-silver-nanoparticles-in-male-wistar-albino-rats
#20
Pannerselvam Balashanmugam, Dharmalingam Jothinathan Mukesh Kumar, Rajenderan Murugan, Perumal Palani, Pudupalayam Thangavelu Kalaichelvan, Hyung Joo Kim, Vijay Singh, Rangarajulu Senthil Kumaran
In modern therapeutics, chemically synthesized drugs have been reported as causing adverse effects including allergies, rashes, itches, and swelling. For the past few decades, silver nanoparticles (AgNPs) have widely been applied in medical domains due to their antimicrobial and wound healing properties. In the present study, different concentrations of phytosynthesized AgNPs-saturated cotton dress fabrics - in comparison to cotton fabrics treated with commercial ointment - were tested for 18days to assess their ability to speed the healing of rats' burn wounds...
January 17, 2017: European Journal of Pharmaceutical Sciences
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