keyword
https://read.qxmd.com/read/38536992/ozone-therapy-improves-early-stages-of-osseointegration-in-ovariectomized-rats
#1
JOURNAL ARTICLE
William Phillip Pereira da Silva, João Matheus Fonseca E Santos, Mônica Caroline de Souza, Stéfany Barbosa, Anderson Maikon de Souza Santos, Edilson Ervolino, Ana Paula Farnezi Bassi, Cortino Sukotjo, Leonardo P Faverani
OBJECTIVE: the aim of this study was to analyze the influence of ozone therapy (OZN) on peri-implant bone repair in critical bones by installing osseointegrated implants in the tibia of ovariectomized rats. METHODOLOGY: ovariectomy was performed on 30 Wistar rats, aged six months (Rattus novergicus), and, after 90 days, osseointegrated implants were installed in each tibial metaphysis. The study groups were divided into the animals that received intraperitoneal ozone at a concentration of 700 mcg/kg - OZ Group (n=15) - and a control group that received an intraperitoneal saline solution and, for this reason, was named the SAL group (n=15)...
2024: Journal of Applied Oral Science: Revista FOB
https://read.qxmd.com/read/38536819/stem-cell-derived-vessels-on-chip-for-cardiovascular-disease-modeling
#2
JOURNAL ARTICLE
Maren Marder, Caroline Remmert, Julius A Perschel, Munkhtur Otgonbayar, Christine von Toerne, Stefanie Hauck, Judith Bushe, Annette Feuchtinger, Bilal Sheikh, Michel Moussus, Matthias Meier
The metabolic syndrome is accompanied by vascular complications. Human in vitro disease models are hence required to better understand vascular dysfunctions and guide clinical therapies. Here, we engineered an open microfluidic vessel-on-chip platform that integrates human pluripotent stem cell-derived endothelial cells (SC-ECs). The open microfluidic design enables seamless integration with state-of-the-art analytical technologies, including single-cell RNA sequencing, proteomics by mass spectrometry, and high-resolution imaging...
March 26, 2024: Cell Reports
https://read.qxmd.com/read/38536171/a-revised-definition-of-left-bundle-branch-block-using-time-to-notch-in-lead-i
#3
JOURNAL ARTICLE
Jeremy S Treger, Ahmad B Allaw, Pouyan Razminia, Dipayon Roy, Amulya Gampa, Swati Rao, Andrew D Beaser, Srinath Yeshwant, Zaid Aziz, Cevher Ozcan, Gaurav A Upadhyay
IMPORTANCE: Current left bundle branch block (LBBB) criteria are based on animal experiments or mathematical models of cardiac tissue conduction and may misclassify patients. Improved criteria would impact referral decisions and device type for cardiac resynchronization therapy. OBJECTIVE: To develop a simple new criterion for LBBB based on electrophysiological studies of human patients, and then to validate this criterion in an independent population. DESIGN, SETTING, AND PARTICIPANTS: In this diagnostic study, the derivation cohort was from a single-center, prospective study of patients undergoing electrophysiological study from March 2016 through November 2019...
March 27, 2024: JAMA Cardiology
https://read.qxmd.com/read/38535706/static-magnetic-field-enhances-the-bone-remodelling-capacity-of-human-demineralized-bone-matrix-in-a-rat-animal-model-of-cranial-bone-defects
#4
JOURNAL ARTICLE
SeyedJamal Hosseini, Houman Parsaei, MirJavad Moosavifar, Narjes Tavakoli, Reza Ahadi, Kaveh Roshanbinfar
The regeneration of bone defects that exceed 2 cm is a challenge for the human body, necessitating interventional therapies. Demineralized bone matrices (DBM) derived from biological tissues have been employed for bone regeneration and possess notable osteoinductive and osteoconductive characteristics. Nevertheless, their efficiency in regenerating critically sized injuries is limited, and therefore additional signaling cues are required. Thanks to the piezoelectric properties of the bone, external physical stimulation is shown to accelerate tissue healing...
March 27, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/38535319/metabolomics-and-lipidomics-analyses-aid-model-classification-of-type-2-diabetes-in-non-human-primates
#5
JOURNAL ARTICLE
Peining Tao, Stacey Conarello, Thomas P Wyche, Nanyan Rena Zhang, Keefe Chng, John Kang, Theodore R Sana
Type 2 diabetes (T2D) is a global public health issue characterized by excess weight, abdominal obesity, dyslipidemia, hyperglycemia, and a progressive increase in insulin resistance. Human population studies of T2D development and its effects on systemic metabolism are confounded by many factors that cannot be controlled, complicating the interpretation of results and the identification of early biomarkers. Aged, sedentary, and overweight/obese non-human primates (NHPs) are one of the best animal models to mimic spontaneous T2D development in humans...
March 9, 2024: Metabolites
https://read.qxmd.com/read/38535287/has-extracorporeal-gas-exchange-performance-reached-its-peak
#6
JOURNAL ARTICLE
Foivos Leonidas Mouzakis, Ali Kashefi, Flutura Hima, Khosrow Mottaghy, Jan Spillner
Extracorporeal gas exchange therapies evolved considerably within the first three-four decades of their appearance, and have since reached a mature stage, where minor alterations and discrete fine-tuning might offer some incremental improvement. A different approach is introduced here, making use of modern, purely diffusive membrane materials, and taking advantage of the elevated concentration gradient ensuing from gas pressure buildup in the gas chamber of the oxygenator. An assortment of silicone membrane gas exchangers were tested in vitro as per a modified protocol in pursuance of assessing their gas exchange efficiency under both regular and high-pressure aeration conditions...
March 17, 2024: Membranes
https://read.qxmd.com/read/38535201/gut-mycobiome-and-asthma
#7
REVIEW
Amjad N Kanj, Joseph H Skalski
This review explores the 'gut-lung axis' in asthma with a focus on commensal fungal organisms. We explore how changes to the intestinal commensal fungal community composition alter lung immune function. We comprehensively review available studies that have profiled the composition of the gut mycobiome in adults and children with asthma, and discuss mechanisms of gut-lung interactions that have been described in animal models of asthma. Studies indicate that intestinal fungal dysbiosis, such as an increased abundance of certain fungi like Candida , can elevate the risk of asthma in children and exacerbate it in adults...
March 1, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38534897/dog-assisted-therapy-in-mental-health-care-a-qualitative-study-on-the-experiences-of-patients-with-intellectual-disabilities
#8
JOURNAL ARTICLE
Anke van Schooten, Nienke Peters-Scheffer, Marie-José Enders-Slegers, Inge Verhagen, Robert Didden
(1) Background: Dog-assisted therapy (DAT) is an experiential intervention to promote psychological, physical, and social functioning in children and adults. Only few studies have been conducted on DAT in adults with a mild intellectual disability or borderline intellectual functioning (MID-BIF). The purpose of this study was to explore the experiences of patients with MID-BIF undergoing DAT in a mental health care facility. (2) Method: Seven patients completed 13 to 15 sessions of DAT. Within two weeks of completing the program, they were interviewed using a semi-structured interview...
February 29, 2024: European journal of investigation in health, psychology and education
https://read.qxmd.com/read/38534878/the-effects-of-negative-pressure-therapy-on-hair-growth-of-mouse-models
#9
JOURNAL ARTICLE
Chun-Yu Cheng, Ming-Huei Cheng, Chin-Yu Yang, Cheng-Han Wang, Joshua Lim, Wei Huang, Chih-Hsin Lin
Negative pressure therapy (NPT) has been shown to facilitate wound healing and promote hair growth in a porcine model. However, there is a paucity of research on the impact of negative pressure on hair growth in murine models. Despite the ability of nude mice to develop hair follicles, the hair they produce is often flawed due to genetically induced keratin disorders, rendering them a pertinent animal model for assessing hair regeneration. Therefore, this study aims to investigate the effects of negative pressure on hair follicle growth in a nude mouse model...
March 27, 2024: Tissue Engineering. Part A
https://read.qxmd.com/read/38534757/to-repair-a-broken-heart-stem-cells-in-ischemic-heart-disease
#10
REVIEW
Theodora M Stougiannou, Konstantinos C Christodoulou, Ioannis Dimarakis, Dimitrios Mikroulis, Dimos Karangelis
Despite improvements in contemporary medical and surgical therapies, cardiovascular disease (CVD) remains a significant cause of worldwide morbidity and mortality; more specifically, ischemic heart disease (IHD) may affect individuals as young as 20 years old. Typically managed with guideline-directed medical therapy, interventional or surgical methods, the incurred cardiomyocyte loss is not always completely reversible; however, recent research into various stem cell (SC) populations has highlighted their potential for the treatment and perhaps regeneration of injured cardiac tissue, either directly through cellular replacement or indirectly through local paracrine effects...
March 8, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534402/transgene-free-cynomolgus-monkey-ipscs-generated-under-chemically-defined-conditions
#11
JOURNAL ARTICLE
Yuliia Tereshchenko, Nesil Esiyok, Enrique Garea-Rodríguez, Daniele Repetto, Rüdiger Behr, Ignacio Rodríguez-Polo
Non-human primates (NHPs) are pivotal animal models for translating novel cell replacement therapies into clinical applications, including validating the safety and efficacy of induced pluripotent stem cell (iPSC)-derived products. Preclinical development and the testing of cell-based therapies ideally comprise xenogeneic (human stem cells into NHPs) and allogenic (NHP stem cells into NHPs) transplantation studies. For the allogeneic approach, it is necessary to generate NHP-iPSCs with generally equivalent quality to the human counterparts that will be used later on in patients...
March 21, 2024: Cells
https://read.qxmd.com/read/38534044/effect-of-a-plant-protein-rich-diet-on-postprandial-phosphate-metabolism-in-healthy-adult-men-a-randomised-controlled-trial
#12
JOURNAL ARTICLE
Kozue Uenishi, Nozomi Kawasaki, Haruka Iseki, Misato Nogata, Yuki Kawabata, Shinsuke Kido
BACKGROUND: This study examined the effects of animal protein- and plant protein-rich diets on postprandial phosphorus metabolism in healthy male subjects. METHODS: The study was conducted by randomised parallel-group comparison of healthy men aged 21-24 years. In Study 1, participants were divided into two groups and consumed either a 70% animal protein diet (AD, n = 6) or a 70% plant protein diet (PD, n = 6). In Study 2, participants were divided into three groups and consumed either AD (n = 10), PD (n = 10) or AD + DF, a 70% animal protein diet loaded with the same amount of fibre as PD (n = 9)...
March 27, 2024: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://read.qxmd.com/read/38533844/combating-antimicrobial-resistance-by-employing-antimicrobial-peptides-immunomodulators-and-therapeutic-agents-against-infectious-diseases
#13
REVIEW
Insha Mehraj, Aflaq Hamid, Ubaid Gani, Nulevino Iralu, Tasaduq Manzoor, Sahar Saleem Bhat
The rising prevalence of multiple-drug-resistant pathogens poses a formidable challenge to conventional antimicrobial treatments. The inability of potent antibiotics to combat these "superbugs" underscores the pressing need for alternative therapeutic agents. Antimicrobial peptides (AMPs) represent an alternative class of antibiotics. AMPs are essential immunomodulatory molecules that are found in various organisms. They play a pivotal role in managing microbial ecosystems and bolstering innate immunity by targeting and eliminating invading microorganisms...
March 27, 2024: ACS Applied Bio Materials
https://read.qxmd.com/read/38533653/tabernacl-temporary-hemodynamic-stabilization-in-vivo
#14
JOURNAL ARTICLE
Rim N Halaby, Christopher G Bruce, D Korel Yildirim, Dogangun Uzun, Toby Rogers, Jaffar M Khan, Andi E Jaimes, Laurie P Grant, Vasilis C Babaliaros, Adam B Greenbaum, Robert J Lederman
BACKGROUND: Acute aortic regurgitation is life-threatening with few nonsurgical options for immediate stabilization. We propose Trans-Aortic Balloon to Ease Regurgitation Applying Counter-Pulsation (TABERNACL), a simple, on-table temporary valve using commercially available equipment to temporize acute severe aortic regurgitation. METHODS: We hypothesize that an appropriately sized commercial balloon dilatation catheter-straddling the aortic annulus and connected to a counterpulsation console-can serve as a temporizing valve to restore hemodynamic stability in acute aortic regurgitation...
March 27, 2024: Circulation. Cardiovascular Interventions
https://read.qxmd.com/read/38533165/bee-sting-venom-as-a-viable-therapy-for-breast-cancer-a-review-article
#15
REVIEW
Aabhas Bindlish, Anupama Sawal
Breast cancer is a kind of aggressive cancer that significantly affects women worldwide, thus making research on alternative and new therapies necessary. The potential impact of bee venom on breast cancer is the main subject of this analysis of this research article. Bee venom has drawn the attention of the world with the help of its constituent ingredients, namely the bioactive compounds, enzymes, and complex blend of proteins. They have a particularly varied chemical makeup and proven anti-cancer capabilities...
February 2024: Curēus
https://read.qxmd.com/read/38532882/bioglass-ceria-nanoparticle-hybrids-for-the-treatment-of-seroma-a-comparative-long-term-study-in-rats
#16
JOURNAL ARTICLE
Michael-Alexander Pais, Athanasios Papanikolaou, Isabel Arenas Hoyos, Robert Nißler, Simone De Brot, Alexander Gogos, Robert Rieben, Mihai A Constantinescu, Martin T Matter, Inge K Herrmann, Ioana Lese
Background: Seroma formation is a common postoperative complication. Fibrin-based glues are typically employed in an attempt to seal the cavity. Recently, the first nanoparticle (NP)-based treatment approaches have emerged. Nanoparticle dispersions can be used as tissue glues, capitalizing on a phenomenon known as 'nanobridging'. In this process, macromolecules such as proteins physically adsorb onto the NP surface, leading to macroscopic adhesion. Although significant early seroma reduction has been shown, little is known about long-term efficacy of NPs...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38532634/ampk-activation-modulates-il-36-induced-inflammatory-responses-by-regulating-i%C3%AE%C2%BAb%C3%AE-expression-in-the-skin
#17
JOURNAL ARTICLE
Yi-Ting Huang, Ling-Ya Chiu, Po-Hsuan Lu, Pa-Fan Hsiao, Jen-Yu Wang, Ping-Hsun Lu, Nan-Lin Wu
BACKGROUND AND PURPOSE: The interleukin (IL)-36 pathway is a critical player in the pathogenesis of pustular psoriasis. However, therapies targeting this pathway are limited or unaffordable (e.g. the anti-IL-36 receptor antibody). AMP-activated protein kinase (AMPK), a regulator of cellular energy and metabolism, is known to participate in inflammatory diseases. However, its role in IL-36-induced skin inflammation remains unclear. Therefore, we sought to investigate the role of AMPK signals in regulating IL-36-induced responses in the skin...
March 26, 2024: British Journal of Pharmacology
https://read.qxmd.com/read/38532284/impacts-of-tissue-context-on-extracellular-vesicles-mediated-cancer-host-cell-communications
#18
REVIEW
Nao Nishida-Aoki, Takahiro Ochiya
Tumor tissue is densely packed with cancer cells, non-cancerous cells, and ECM, forming functional structures. Cancer cells transfer extracellular vesicles (EVs) to modify surrounding normal cells into cancer-promoting cells, establishing a tumor-favorable environment together with other signaling molecules and structural components. Such tissue environments largely affect cancer cell properties, and so as EV-mediated cellular communications within tumor tissue. However, current research on EVs focuses on functional analysis of vesicles isolated from the liquid phase, including cell culture supernatants and blood draws, 2D-cultured cell assays, or systemic analyses on animal models for biodistribution...
March 26, 2024: Cancer Science
https://read.qxmd.com/read/38532203/topical-application-of-ozonated-sunflower-oil-accelerates-the-healing-of-lesions-of-cutaneous-leishmaniasis-in-mice-under-meglumine-antimoniate-treatment
#19
JOURNAL ARTICLE
Ana Paula Pivotto, Lucas Bonatto de Souza Lima, Alexandra Michelon, Camilla Zottesso Pellon Ferreira, Rinaldo Ferreira Gandra, Thaís Soprani Ayala, Rafael Andrade Menolli
Besides being scarce, the drugs available for treating cutaneous leishmaniasis have many adverse effects. Ozone is an option to enhance the standard treatment due to the wound-healing activity reported in the literature. In this study, we evaluated the efficiency of ozonated sunflower oil as an adjuvant in treating cutaneous lesions caused by Leishmania amazonensis. BALB/c mice were infected with L. amazonensis, and after the lesions appeared, they were treated in four different schedules using the drug treatment with meglumine antimoniate (Glucantime®), with or without ozonated oil...
March 27, 2024: Medical Microbiology and Immunology
https://read.qxmd.com/read/38531354/antibiotic-bone-cement-accelerates-diabetic-foot-wound-healing-elucidating-the-role-of-rock1-protein-expression
#20
JOURNAL ARTICLE
Chenglan Yang, Dali Wang
Clinical studies indicate antibiotic bone cement with propeller flaps improves diabetic foot wound repair and reduces amputation rates, but the molecular mechanisms, particularly key proteins' role remain largely unexplored. This study assessed the efficacy of antibiotic bone cement for treating diabetic foot wounds, focusing on molecular impact on ROCK1. Sixty patients were randomized into experimental (EXP, n = 40) and control (CON, n = 20) groups, treated with antibiotic bone cement and negative pressure...
April 2024: International Wound Journal
keyword
keyword
17999
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.