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https://www.readbyqxmd.com/read/28226451/non-invasive-imaging-of-ventricular-activation-during-pacing-and-arrhythmia-methods-and-validation
#1
Long Yu, Steven Pogwizd, Bin He, Long Yu, Steven Pogwizd, Bin He, Bin He, Steven Pogwizd, Long Yu
Cardiovascular disease continued to be a leading killer world widely. Each year, about 400,000 cases of sudden cardiac arrest are reported in the U.S. alone. Clinically, radio-frequency ablative procedure has become widely applied in the treatment of ventricular arrhythmia. Non-invasive approaches have been demonstrated to be able to provide important information on the arrhythmogenesis and potentially assist in the clinical practice. In this work, we develop and validate a novel temporal sparse based imaging method, Cardiac Electrical Sparse Imaging (CESI)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28212379/distribution-and-abundance-of-key-vectors-of-rift-valley-fever-and-other-arboviruses-in-two-ecologically-distinct-counties-in-kenya
#2
Rosemary Sang, Samwel Arum, Edith Chepkorir, Gladys Mosomtai, Caroline Tigoi, Faith Sigei, Olivia Wesula Lwande, Tobias Landmann, Hippolyte Affognon, Clas Ahlm, Magnus Evander
BACKGROUND: Rift Valley fever (RVF) is a mosquito-borne viral zoonosis of ruminants and humans that causes outbreaks in Africa and the Arabian Peninsula with significant public health and economic consequences. Humans become infected through mosquito bites and contact with infected livestock. The virus is maintained between outbreaks through vertically infected eggs of the primary vectors of Aedes species which emerge following rains with extensive flooding. Infected female mosquitoes initiate transmission among nearby animals, which amplifies virus, thereby infecting more mosquitoes and moving the virus beyond the initial point of emergence...
February 17, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28207269/a-biocompatible-injectable-hydrogel-with-potent-wound-healing-and-antibacterial-properties
#3
Jiaul Hoque, Relekar G Prakash, Krishnamoorthy Paramanandham, Bibek R Shome, Jayanta Haldar
Two component injectable hydrogels that cross-link in-situ have been used as non-invasive wound-filling devices, i.e., sealants. These materials carry a variety of functions at the wound sites such as seal leaks, cease unwanted bleeding, bind tissues together, and assist in wound healing process. However, commonly used sealants typically lack antibacterial properties. Since bacterial infection at the wound site is very common, bioadhesive materials with intrinsic antibacterial properties are urgently required...
February 16, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28194740/potential-of-burkholderia-seminalis-tc3-4-2r3-as-biocontrol-agent-against-fusarium-oxysporum-evaluated-by-mass-spectrometry-imaging
#4
Francisca Diana da Silva Araújo, Welington Luiz Araújo, Marcos Nogueira Eberlin
Species of genus Burkholderia display different interaction profiles in the environment, causing either several diseases in plants and animals or being beneficial to some plants, promoting their growth, and suppressing phytopathogens. Burkholderia spp. also produce many types of biomolecules with antimicrobial activity, which may be commercially used to protect crops of economic interest, mainly against fungal diseases. Herein we have applied matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) to investigate secondary metabolites produced by B...
February 13, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28193253/artemisia-spp-essential-oils-against-the-disease-carrying-blowfly-calliphora-vomitoria
#5
Stefano Bedini, Guido Flamini, Francesca Cosci, Roberta Ascrizzi, Maria Cristina Echeverria, Lucia Guidi, Marco Landi, Andrea Lucchi, Barbara Conti
BACKGROUND: Synanthropic flies play a considerable role in the transmission of pathogenic and non-pathogenic microorganisms. In this work, the essential oil (EO) of two aromatic plants, Artemisia annua and Artemisia dracunculus, were evaluated for their abilities to control the blowfly Calliphora vomitoria. Artemisia annua and A. dracunculus EOs were extracted, analysed and tested in laboratory bioassays. Besides, the physiology of EOs toxicity and the EOs antibacterial and antifungal properties were evaluated...
February 13, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28150103/purification-biochemical-characterization-and-amino-acid-sequence-of-a-novel-type-of-lectin-from-aplysia-dactylomela-eggs-with-antibacterial-antibiofilm-potential
#6
Rômulo Farias Carneiro, Renato Cézar Farias Torres, Renata Pinheiro Chaves, Mayron Alves de Vasconcelos, Bruno Lopes de Sousa, André Castelo Rodrigues Goveia, Francisco Vassiliepe Arruda, Maria Nágila Carneiro Matos, Helena Matthews-Cascon, Valder Nogueira Freire, Edson Holanda Teixeira, Celso Shiniti Nagano, Alexandre Holanda Sampaio
A new lectin from Aplysia dactylomela eggs (ADEL) was isolated by affinity chromatography on HCl-activated Sepharose™ media. Hemagglutination caused by ADEL was inhibited by several galactosides, mainly galacturonic acid (Ka = 6.05 × 10(6) M(-1)). The primary structure of ADEL consists of 217 residues, including 11 half-cystines involved in five intrachain and one interchain disulfide bond, resulting in a molecular mass of 57,228 ± 2 Da, as determined by matrix-assisted laser desorption/ionization time of flight mass spectrometry...
February 1, 2017: Marine Biotechnology
https://www.readbyqxmd.com/read/28149187/biochemical-analysis-and-bone-remodeling-in-response-to-oophorectomy-and-aquatic-training
#7
Helena Ribeiro Souza, Ana Paula Girol, Adriana Paula Sanchez Schiaveto, Mairto Roberis Geromel, Melina Mizusaki Iyomasa, Maurício Ferraz DE Arruda
OBJECTIVE: To investigate whether swimming could prevent bone loss and could be indicated to assist in treatment of osteoporosis. METHODS: Female rats were divided into 4 groups (n=6), two of them were oophorectomized. Animals from two groups, one oophorectomized and another not oophorectomized, underwent aquatic training for eight weeks. After training, the animals were sacrificed and their blood was collected for calcium and alkaline phosphatase serum dosage; the femur was removed and subjected to radiological and histological densitometry analysis to assess bone loss and osteoclast counting on femoral head and neck...
September 2016: Acta Ortopedica Brasileira
https://www.readbyqxmd.com/read/28125808/coagulation-management-in-jersey-calves-an-ex-vivo-study
#8
Sabine Gröning, Judith Maas, Svenja van Geul, Rolf Rossaint, Ulrich Steinseifer, Oliver Grottke
OBJECTIVE: Jersey calves are frequently used as an experimental animal model for in vivo testing of cardiac assist devices or orthopedic implants. In this ex vivo study, we analyzed the coagulation system of the Jersey calves and the potential of human-based coagulation management to circumvent perioperative bleeding complications during surgery. Experimental Procedure: Blood from 7 Jersey calves was subjected to standard laboratory tests and thromboelastometry analysis. An ex vivo model of dilutional coagulopathy was used to study the effects of fibrinogen or prothrombin complex concentrate supplementation...
January 27, 2017: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/28122680/the-society-of-thoracic-surgeons-expert-consensus-for-the-resuscitation-of-patients-who-arrest-after-cardiac-surgery
#9
(no author information available yet)
The Society of Thoracic Surgeons Task Force on Resuscitation After Cardiac Surgery provides this professional society perspective on resuscitation in patients who arrest after cardiac surgery. This document was created using a multimodal methodology for evidence generation and includes information from existing guidelines, from the International Liaison Committee on Resuscitation, from our own structured literature reviews on issues particular to cardiac surgery, and from an international survey on resuscitation hosted by CTSNet...
January 19, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28113945/validation-of-a-portable-low-power-deep-brain-stimulation-device-through-anxiolytic-effects-in-a-laboratory-rat-model
#10
Abbas Z Kouzani, Rajas P Kale, Pablo Patricio Zarate-Garza, Michael Berk, Ken Walder, Susannah J Tye
Deep brain stimulation (DBS) devices deliver electrical pulses to neural tissue through an electrode. To study the mechanisms and therapeutic benefits of deep brain stimulation, murine preclinical research is necessary. However, conducting naturalistic long-term, uninterrupted animal behavioral experiments can be difficult with bench-top systems. The reduction of size, weight, power consumption, portability, and cost of DBS devices can assist the progress of this research in animal studies. A low power, low weight, miniature DBS device is presented in this paper...
November 15, 2016: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28107849/attitudes-to-and-beliefs-about-animal-assisted-therapy-for-children-with-disabilities
#11
Esther Yap, Adam Scheinberg, Katrina Williams
OBJECTIVES: This study assessed the attitudes and beliefs surrounding animal-assisted therapy (AAT) for the rehabilitation of children with disabilities at the Royal Children's Hospital (RCH), focusing specifically on cerebral palsy (CP), autism spectrum disorder (ASD) and acquired brain injury (ABI). This was an initial step to inform future AAT research and to understand the feasibility of interventions. DESIGN/SETTING/OUTCOME MEASURES: An online survey asking participants their opinions about the inclusion of AAT, and potential barriers to its introduction in a tertiary hospital setting was advertised on the RCH Intranet from 3 March 2015 to 3 April 2015...
February 2017: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/28074089/antiviral-activity-of-animal-venom-peptides-and-related-compounds
#12
REVIEW
Élida Cleyse Gomes da Mata, Caroline Barbosa Farias Mourão, Marisa Rangel, Elisabeth Ferroni Schwartz
Viruses exhibit rapid mutational capacity to trick and infect host cells, sometimes assisted through virus-coded peptides that counteract host cellular immune defense. Although a large number of compounds have been identified as inhibiting various viral infections and disease progression, it is urgent to achieve the discovery of more effective agents. Furthermore, proportionally to the great variety of diseases caused by viruses, very few viral vaccines are available, and not all are efficient. Thus, new antiviral substances obtained from natural products have been prospected, including those derived from venomous animals...
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/28062006/challenges-in-the-rabbit-haemorrhagic-disease-2-rhdv2-molecular-diagnosis-of-vaccinated-rabbits
#13
C L Carvalho, E L Duarte, M Monteiro, A Botelho, T Albuquerque, M Fevereiro, A M Henriques, S S Barros, Margarida Dias Duarte
Molecular methods are fundamental tools for the diagnosis of viral infections. While interpretation of results is straightforward for unvaccinated animals, where positivity represents ongoing or past infections, the presence of vaccine virus in the tissues of recently vaccinated animals may mislead diagnosis. In this study, we investigated the interference of RHDV2 vaccination in the results of a RT-qPCR for RHDV2 detection, and possible associations between mean Cq values of five animal groups differing in age, vaccination status and origin (domestic/wild)...
January 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28043585/occurrence-of-zoonotic-tuberculosis-in-occupationally-exposed-high-risk-groups-in-peshawar-pakistan
#14
Irfan Khattak, Muhammad H Mushtaq, Sultan Ayaz, Mansur U D Ahmad, Sadeeq U Rahman
OBJECTIVE/BACKGROUND: To determine the occurrence of active pulmonary tuberculosis (TB) due to Mycobacterium bovis in abattoir workers, butchers, livestock farmers, and veterinarians and to document their knowledge and practices regarding bovine TB (bTB). METHODS: A cross-sectional study was conducted among abattoir workers, butchers, livestock farmers, veterinary doctors, and veterinary assistants. Sputum samples were collected from the respondents with a chronic cough and data on sociodemographic conditions, knowledge, and practices regarding TB were obtained...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28042343/limited-tumor-tissue-drug-penetration-contributes-to-primary-resistance-against-angiogenesis-inhibitors
#15
Szilvia Torok, Melinda Rezeli, Olga Kelemen, Akos Vegvari, Kenichi Watanabe, Yutaka Sugihara, Anna Tisza, Timea Marton, Ildiko Kovacs, Jozsef Tovari, Viktoria Laszlo, Thomas H Helbich, Balazs Hegedus, Thomas Klikovits, Mir Alireza Hoda, Walter Klepetko, Sandor Paku, Gyorgy Marko-Varga, Balazs Dome
Resistance mechanisms against antiangiogenic drugs are unclear. Here, we correlated the antitumor and antivascular properties of five different antiangiogenic receptor tyrosine kinase inhibitors (RTKIs) (motesanib, pazopanib, sorafenib, sunitinib, vatalanib) with their intratumoral distribution data obtained by matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI). In the first mouse model, only sunitinib exhibited broad-spectrum antivascular and antitumor activities by simultaneously suppressing vascular endothelial growth factor receptor-2 (VEGFR2) and desmin expression, and by increasing intratumoral hypoxia and inhibiting both tumor growth and vascularisation significantly...
2017: Theranostics
https://www.readbyqxmd.com/read/28034593/one-health-proof-of-concept-bringing-a-transdisciplinary-approach-to-surveillance-for-zoonotic-viruses-at-the-human-wild-animal-interface
#16
Terra R Kelly, William B Karesh, Christine Kreuder Johnson, Kirsten V K Gilardi, Simon J Anthony, Tracey Goldstein, Sarah H Olson, Catherine Machalaba, Jonna A K Mazet
As the world continues to react and respond inefficiently to emerging infectious diseases, such as Middle Eastern Respiratory Syndrome and the Ebola and Zika viruses, a growing transdisciplinary community has called for a more proactive and holistic approach to prevention and preparedness - One Health. Such an approach presents important opportunities to reduce the impact of disease emergence events and also to mitigate future emergence through improved cross-sectoral coordination. In an attempt to provide proof of concept of the utility of the One Health approach, the US Agency for International Development's PREDICT project consortium designed and implemented a targeted, risk-based surveillance strategy based not on humans as sentinels of disease but on detecting viruses early, at their source, where intervention strategies can be implemented before there is opportunity for spillover and spread in people or food animals...
February 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28028909/regulation-of-injury-induced-ovarian-regeneration-by-activation-of-oogonial-stem-cells
#17
Piril Erler, Alexandra Sweeney, James R Monaghan
Some animals have the ability to generate large numbers of oocytes throughout life. This raises the question whether persistent adult germline stem cell populations drive continuous oogenesis and whether they are capable of mounting a regenerative response after injury. Here we demonstrate the presence of adult oogonial stem cells (OSCs) in the adult axolotl salamander ovary and show that ovarian injury induces OSC activation and functional regeneration of the ovaries to reproductive capability. Cells that have morphological similarities to germ cells were identified in the developing and adult ovaries via histological analysis...
January 2017: Stem Cells
https://www.readbyqxmd.com/read/28009676/effectiveness-of-meaningful-occupation-interventions-for-people-living-with-dementia-in-residential-aged-care-a-systematic-review
#18
Catherine Travers, Deborah Brooks, Sonia Hines, Maria O'Reilly, Mitchell McMaster, Wei He, Margaret MacAndrew, Elaine Fielding, Lina Karlsson, Elizabeth Beattie
BACKGROUND: The ability to participate in valued activities, whether for work, leisure or family, is an important aspect of personal identity. In dementia, progressive memory loss means that abilities developed over a lifetime begin to be lost as well, contributing to the loss of self and identity. Some studies have reported that activities or interventions tailored to be meaningful to the person with dementia (defined as any activity important to the individual) are more effective in addressing behavioral and psychological symptoms of dementia (BPSD) and improving quality of life (QoL) than those that are not so tailored...
December 2016: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/27981504/isolation-identification-and-screening-of-potential-probiotic-bacteria-in-milk-from-south-african-saanen-goats
#19
Goitsemang Makete, Olayinka A Aiyegoro, Mapitsi S Thantsha
This study aimed to evaluate lactic acid bacteria isolates from Saanen goats' milk for probiotic attributes, thereby determining their potential as direct-fed microbials for goats. Isolates were identified using API 50CH system, 16S rDNA sequencing and matrix-assisted laser desorption ionization-time of flight mass spectrometry. All 17 isolates obtained were identified as Lactobacillus plantarum except one identified as Pediococcus acidilactici. Four isolates identified as L. plantarum (Accession numbers KJ026587...
December 15, 2016: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/27933135/impact-of-laparoscopic-surgery-training-laboratory-on-surgeon-s-performance
#20
REVIEW
Fabio C M Torricelli, Joao Arthur B A Barbosa, Giovanni S Marchini
Minimally invasive surgery has been replacing the open standard technique in several procedures. Similar or even better postoperative outcomes have been described in laparoscopic or robot-assisted procedures when compared to open surgery. Moreover, minimally invasive surgery has been providing less postoperative pain, shorter hospitalization, and thus a faster return to daily activities. However, the learning curve required to obtain laparoscopic expertise has been a barrier in laparoscopic spreading. Laparoscopic surgery training laboratory has been developed to aid surgeons to overcome the challenging learning curve...
November 27, 2016: World Journal of Gastrointestinal Surgery
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