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https://www.readbyqxmd.com/read/29678128/spirpep-an-in-silico-digestion-based-platform-to-assist-bioactive-peptides-discovery-from-a-genome-wide-database
#1
Krittima Anekthanakul, Apiradee Hongsthong, Jittisak Senachak, Marasri Ruengjitchatchawalya
BACKGROUND: Bioactive peptides, including biological sources-derived peptides with different biological activities, are protein fragments that influence the functions or conditions of organisms, in particular humans and animals. Conventional methods of identifying bioactive peptides are time-consuming and costly. To quicken the processes, several bioinformatics tools are recently used to facilitate screening of the potential peptides prior their activity assessment in vitro and/or in vivo...
April 20, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/29668896/critical-review-of-research-methods-used-to-consider-the-impact-of-human-animal-interaction-on-older-adults-health
#2
Erika Friedmann, Nancy R Gee
Background and Objectives: Most research on human-animal interaction (HAI) and human health focuses on one of three perspectives: (a) health effects of pet ownership; (b) health effects of contact with a companion animal; or (c) health effects of animal-assisted interventions including animal-assisted therapies, and animal-assisted activities. Methods: We reviewed research methods used to address each perspective, within the context of human aging, and identified challenges associated with these methods...
April 12, 2018: Gerontologist
https://www.readbyqxmd.com/read/29621141/correcting-calcium-dysregulation-in-chronic-heart-failure-using-serca2a-gene-therapy
#3
REVIEW
T Jake Samuel, Ryan P Rosenberry, Seungyong Lee, Zui Pan
Chronic heart failure (CHF) is a major contributor to cardiovascular disease and is the leading cause of hospitalization for those over the age of 65, which is estimated to account for close to seventy billion dollars in healthcare costs by 2030 in the US alone. The successful therapies for preventing and reversing CHF progression are urgently required. One strategy under active investigation is to restore dysregulated myocardial calcium (Ca2+ ), a hallmark of CHF. It is well established that intracellular Ca2+ concentrations are tightly regulated to control efficient myocardial systolic contraction and diastolic relaxation...
April 5, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29617398/impact-of-an-animal-assisted-therapy-programme-on-physiological-and-psychosocial-variables-of-paediatric-oncology-patients
#4
Nathiana B Silva, Flávia L Osório
The objective of this study was to propose an intervention and safety protocol for performing animal-assisted therapy (AAT) and evaluating its efficacy in children under outpatient oncological treatment based on psychological, physiological, and quality of life indicators for the children and caregivers. The sample consisted of 24 children diagnosed with leukaemia and solid tumours (58% girls with a mean age of 8.0 years) who underwent an AAT programme consisting of three 30-min sessions in an open group. Two dogs (one Labrador retriever and one golden retriever) were used, and activities such as sensory stimulation, gait training, and socialization were conducted...
2018: PloS One
https://www.readbyqxmd.com/read/29574151/oviduct-morphology-and-estrogen-receptors-er%C3%AE-and-er%C3%AE-expression-in-captive-chinchilla-lanigera-hystricomorpha-chinchillidae
#5
Mariana Machado-Neves, Wiviane Alves de Assis, Mardelene Geísa Gomes, Cleida Aparecida de Oliveira
Chinchilla lanigera is a hystricomorph rodent from South America whose reproductive biology presents particular characteristics that distinguishes it from other Rodentia species, such as low reproductive rate, seasonal breeding pattern, and long estrous cycle. Nevertheless, reproductive features in female chinchillas are still poorly investigated, with a scarce knowledge concerning the estrous cycle and the histology of reproductive organs. In this study, we investigate the morphology, histomorphometry, secretory activity, and immunolocalization of estrogen receptors ERα and ERβ in oviducts of nulliparous chinchillas, euthanized at fall season in Brazil...
March 22, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29563027/effect-of-a-robotic-seal-on-the-motor-activity-and-sleep-patterns-of-older-people-with-dementia-as-measured-by-wearable-technology-a-cluster-randomised-controlled-trial
#6
Wendy Moyle, Cindy Jones, Jenny Murfield, Lukman Thalib, Elizabeth Beattie, David Shum, Siobhan O'Dwyer, M Cindy Mervin, Brian Draper
OBJECTIVES: The robotic seal, PARO, has been used as an alternative to animal-assisted therapies with residents with dementia in long-term care, yet understanding of its efficacy is limited by a paucity of research. We explored the effects of PARO on motor activity and sleep patterns, as measured by a wearable triaxial accelerometer. STUDY DESIGN: Cluster-randomised controlled trial, involving 28 facilities in Queensland, Australia. Nine facilities were randomised to the PARO group (individual, non-facilitated, 15-min sessions three afternoons per week for 10 weeks), 10 to a plush toy (PARO with robotic features disabled) and nine to usual care...
April 2018: Maturitas
https://www.readbyqxmd.com/read/29554095/the-mixture-of-cashew-nut-shell-liquid-and-castor-oil-results-in-an-efficient-larvicide-against-aedes-aegypti-that-does-not-alter-embryo-fetal-development-reproductive-performance-or-dna-integrity
#7
Juliana Miron Vani, Maria Tereza Ferreira Duenhas Monreal, Sarah Alves Auharek, Andréa Luiza Cunha-Laura, Eduardo José de Arruda, Alessandra Ramos Lima, Cicera Maria da Silva, Andréia Conceição Milan Brochado Antoniolli-Silva, Dênis Pires de Lima, Adilson Beatriz, Rodrigo Juliano Oliveira
Dengue fever, chikungunya fever and Zika virus are epidemics in Brazil that are transmitted by mosquitoes, such as Aedes aegypti or Aedes albopictus. The liquid from shells of cashew nuts is attractive for its important biological and therapeutic activities, which include toxicity to mosquitoes of the genus Aedes. The present study evaluated the effects of a mixture of surfactants from natural cashew nutshell liquid and castor oil (named TaLCC-20) on the mortality of larvae and on the reproductive performance, embryonic and fetal development and genetic stability of Swiss mice...
2018: PloS One
https://www.readbyqxmd.com/read/29524515/mdma-assisted-psychotherapy-for-ptsd-are-memory-reconsolidation-and-fear-extinction-underlying-mechanisms
#8
REVIEW
Allison A Feduccia, Michael C Mithoefer
MDMA-assisted psychotherapy for treatment of PTSD has recently progressed to Phase 3 clinical trials and received Breakthrough Therapy designation by the FDA. MDMA used as an adjunct during psychotherapy sessions has demonstrated effectiveness and acceptable safety in reducing PTSD symptoms in Phase 2 trials, with durable remission of PTSD diagnosis in 68% of participants. The underlying psychological and neurological mechanisms for the robust effects in mitigating PTSD are being investigated in animal models and in studies of healthy volunteers...
March 7, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29510254/the-functionality-of-prebiotics-as-immunostimulant-evidences-from-trials-on-terrestrial-and-aquatic-animals
#9
REVIEW
Asad Nawaz, Allah Bakhsh Javaid, Sana Irshad, Seyed Hossein Hoseinifar, Hanguo Xiong
The gut immune system is, the main option for maintaining host's health, affected by numerous factors comprising dietary constituents and commensal bacteria. These dietary components that affect the intestinal immunity and considered as an alternative of antibiotics are called immunosaccharides. Fructooligosaccharide (FOS), Galactooligosaccharide (GOS), inulin, dietary carbohydrates, and xylooligosaccharide (XOS) are among the most studied prebiotics in human as well as in aquaculture. Although prebiotics and probiotics have revealed potential as treatment for numerous illnesses in both human and fish, a comprehensive understanding of the molecular mechanism behind direct and indirect effect on the intestinal immune response will help more and perhaps extra effective therapy intended for ailments...
March 3, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29467760/microrna-regulation-of-host-immune-responses-following-fungal-exposure
#10
REVIEW
Tara L Croston, Angela R Lemons, Donald H Beezhold, Brett J Green
Fungal bioaerosols are ubiquitous in the environment and human exposure can result in a variety of health effects ranging from systemic, subcutaneous, and cutaneous infections to respiratory morbidity including allergy, asthma, and hypersensitivity pneumonitis. Recent research has focused on the role of microRNAs (miRNAs) following fungal exposure and is overlooked, yet important, group of regulators capable of influencing fungal immune responses through a variety of cellular mechanisms. These small non-coding ribose nucleic acids function to regulate gene expression at the post-transcriptional level and have been shown to participate in multiple disease pathways including cancer, heart disease, apoptosis, as well as immune responses to microbial hazards and occupational allergens...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29457292/antibodies-against-h3-and-h4-histones-from-the-sera-of-hiv-infected-patients-catalyze-site-specific-degradation-of-these-histones
#11
Svetlana V Baranova, Pavel S Dmitrenok, Anastasiya D Zubkova, Nikita V Ivanisenko, Elena S Odintsova, Valentina N Buneva, Georgy A Nevinsky
Histones and their posttranslational modified forms play pivotal roles in chromatin functioning and gene transcription. Also, histones are harmful when they enter the intercellular space; their administration to animals results in systemic inflammatory and toxic responses. Autoantibodies having enzymatic activities (abzymes) are the specific feature of several autoimmune and viral diseases. Electrophoretically homogeneous IgGs containing no canonical proteases were purified from sera of HIV-infected patients by using several affinity chromatographies...
February 19, 2018: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/29441797/animal-assisted-intervention-and-dementia-a-systematic-review
#12
Michelle L Yakimicki, Nancy E Edwards, Elizabeth Richards, Alan M Beck
This review discusses the relationship between animal-assisted interventions (AAI) and behavioral and psychological symptoms of dementia (BPSD). A systematic search was conducted within CINAHL, Web of Science CAB Abstracts, PubMed, Abstracts in Social Gerontology, Google Scholar, and PsycINFO for primary research articles. A total of 32 studies were included in the final review. Variation was noted in study designs and in study setting. Twenty-seven of 32 studies used dogs as the intervention. Agitation/aggression showed a significant decrease in nine of 15 studies...
February 1, 2018: Clinical Nursing Research
https://www.readbyqxmd.com/read/29410003/pig-kdm5b-mrna-expression-profiles-of-different-tissues-and-testicular-cells-and-association-analyses-with-testicular-morphology-traits
#13
Yang Cui, Yanghai Zhang, Zhenyu Wei, Jiayang Gao, Ting Yu, Rui Chen, Xiaoyan Lv, Chuanying Pan
Lysine specific demethylase 5B gene (KDM5B, also known as JARID1B or PLU-1), encoding an enzyme of the lysine-specific histone demethylase family, has been reported to regulate androgen receptor transcriptional activity and male reproduction. To fully study the expression characteristics and genetic effects of pig KDM5B gene, the objective of this study was to investigate the mRNA expression profiles of KDM5B among different tissues and testicular cells (spermatogonia stem cells, SSCs; sertoli cells, SCs; leydig cells, LCs), as well as to explore the insertion/deletion (indel) variations of this gene...
January 30, 2018: Gene
https://www.readbyqxmd.com/read/29407896/free-gossypol-supplementation-frequency-and-reproductive-toxicity-in-young-bulls
#14
L K Hatamoto-Zervoudakis, M F Duarte Júnior, J T Zervoudakis, T F Motheo, R P Silva-Marques, P P Tsuneda, M Nichi, B S E Santo, R D Almeida
The aim of the present study was to analyze seminal quality of young bulls subjected to different frequencies of gossypol supplementation. Forty-eight Nellore bulls, with 19 months of age and weighing 357.8 ± 7.2 kg, were used in this study. Animals were fed with 10.5 kg of standard supplement containing free-gossypol from whole cottonseed (WCS) at the following frequency: 3x/week (G3x), 5x/week (G5x) or 7x/week (G7x - Control). Additionally, a negative control was provided, and the treated animals received only mineral supplement (MM) ad libtum...
January 9, 2018: Theriogenology
https://www.readbyqxmd.com/read/29386286/modifications-to-the-foot-and-mouth-disease-virus-2a-peptide-influence-on-polyprotein-processing-and-virus-replication
#15
Jonas Kjær, Graham J Belsham
Foot-and-mouth disease virus (FMDV) has a positive-sense ssRNA genome that includes a single, large, open reading frame encoding a polyprotein. The co-translational "cleavage" of this polyprotein at the 2A/2B junction is mediated by the 2A peptide (18 residues in length) using a non-proteolytic mechanism termed "ribosome skipping" or "StopGo". Multiple variants of the 2A polypeptide with this property among the picornaviruses share a conserved C-terminal motif (D(V/I)E(S/T)NPG↓P). The impact of 2A modifications within this motif on FMDV protein synthesis, polyprotein processing and virus viability were investigated...
January 31, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29381352/design-and-mechanism-of-s-3-amino-4-difluoromethylenyl-cyclopent-1-ene-1-carboxylic-acid-a-highly-potent-%C3%AE-aminobutyric-acid-aminotransferase-inactivator-for-the-treatment-of-addiction
#16
Jose I Juncosa, Kenji Takaya, Hoang V Le, Matthew J Moschitto, Pathum M Weerawarna, Romila Mascarenhas, Dali Liu, Stephen L Dewey, Richard B Silverman
γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system. Inhibition of GABA aminotransferase (GABA-AT), a pyridoxal 5'-phosphate (PLP)-dependent enzyme that degrades GABA, has been established as a possible strategy for the treatment of substance abuse. The raised GABA levels that occur as a consequence of this inhibition have been found to antagonize the rapid release of dopamine in the ventral striatum (nucleus accumbens) that follows an acute challenge by an addictive substance...
January 30, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29380329/in-vivo-electrical-stimulation-for-the-assessment-of-skeletal-muscle-contractile-function-in-murine-models
#17
Kaio F Vitzel, Marco A Fortes, Gabriel Nasri Marzuca-Nassr, Maria V M Scervino, Carlos H Pinheiro, Leonardo R Silveira, Rui Curi
Skeletal muscle electrical stimulation is commonly used for clinical purposes, assisting recovery, preservation, or even improvement of muscle mass and function in healthy and pathological conditions. Additionally, it is a useful research tool for evaluation of skeletal muscle contractile function. It may be applied in vitro, using cell culture or isolated fibers/muscles, and in vivo, using human subjects or animal models (neuromuscular electrical stimulation - NMES). This chapter focuses on the electrical stimulation of the sciatic nerve as a research method for evaluation of the contractile properties of murine hind limb muscles...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29378182/activation-of-mitochondrial-fusion-provides-a-new-treatment-for-mitochondria-related-diseases
#18
Aliz Szabo, Katalin Sumegi, Katalin Fekete, Eniko Hocsak, Balazs Debreceni, Gyorgy Setalo, Krisztina Kovacs, Laszlo Deres, Andras Kengyel, Dominika Kovacs, Jozsef Mandl, Miklos Nyitrai, Mark A Febbraio, Ferenc Gallyas, Balazs Sumegi
Mitochondria fragmentation destabilizes mitochondrial membranes, promotes oxidative stress and facilitates cell death, thereby contributing to the development and the progression of several mitochondria-related diseases. Accordingly, compounds that reverse mitochondrial fragmentation could have therapeutic potential in treating such diseases. BGP-15, a hydroxylamine derivative, prevents insulin resistance in humans and protects against several oxidative stress-related diseases in animal models. Here we show that BGP-15 promotes mitochondrial fusion by activating optic atrophy 1 (OPA1), a GTPase dynamin protein that assist fusion of the inner mitochondrial membranes...
January 26, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29370127/food-acquisition-through-private-and-public-social-networks-and-its-relationship-with-household-food-security-among-various-socioeconomic-statuses-in-south-korea
#19
Sohyun Park, Kirang Kim
This study was conducted to understand food acquisition practices from social networks and its relationship with household food security. In-depth interviews and a survey on food security were conducted with twenty-nine mothers and one father in metropolitan areas of South Korea. Many families acquired food from their extended families, mainly participants' mothers. Between low-income and non-low-income households, there was a pattern of more active sharing of food through private networks among non-low-income households...
January 25, 2018: Nutrients
https://www.readbyqxmd.com/read/29368001/pharmacokinetics-tissue-localization-toxicity-and-treatment-efficacy-in-the-first-small-animal-rabbit-model-of-intra-arterial-chemotherapy-for-retinoblastoma
#20
Anthony B Daniels, Michael T Froehler, Janene M Pierce, Amy H Nunnally, M Wade Calcutt, Thomas M Bridges, David C LaNeve, Phillip E Williams, Kelli L Boyd, Michelle L Reyzer, Craig W Lindsley, Debra L Friedman, Ann Richmond
Purpose: Current intra-arterial chemotherapy (IAC) drug regimens for retinoblastoma have ocular and vascular toxicities. No small-animal model of IAC exists to test drug efficacy and toxicity in vivo for IAC drug discovery. The purpose of this study was to develop a small-animal model of IAC and to analyze the ocular tissue penetration, distribution, pharmacokinetics, and treatment efficacy. Methods: Following selective ophthalmic artery (OA) catheterization, melphalan (0...
January 1, 2018: Investigative Ophthalmology & Visual Science
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