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https://www.readbyqxmd.com/read/28723499/prospective-evaluation-of-the-impact-of-antiangiogenic-treatment-on-cognitive-functions-in-metastatic-renal-cancer
#1
Florence Joly, Natacha Heutte, Brigitte Duclos, Sabine Noal, Isabelle Léger-Hardy, Sarah Dauchy, Nadine Longato, Laurence Desrues, Nadine Houede, Marie Lange, Emmanuel Sevin, Chantal Rieux, Bénédicte Clarisse, Hélène Castel, Bernard Escudier
BACKGROUND: Little is known about the cognitive effects of antiangiogenic therapies (AATs) in metastatic renal cell carcinoma (mRCC) and their relation with fatigue. OBJECTIVE: To evaluate the impact of AATs on cognition and its connection with fatigue and quality of life (QoL) in patients with mRCC. DESIGN, SETTING, AND PARTICIPANTS: This prospective study enrolled 75 patients starting AAT as first or second line for mRCC and assessed them at 3 mo (n=58) and 6 mo (n=50)...
December 15, 2016: European Urology Focus
https://www.readbyqxmd.com/read/28721587/genetically-engineered-cell-lines-for-%C3%AE-1-antitrypsin-expression
#2
Qianqian Ji, Caiping Guo, Chen Xie, Yingdan Wu, Pei Zhang, Hui Li, Yongjun Lu
OBJECTIVES: To establish genetically modified cell lines that can produce functional α1-antitrypsin (AAT), by CRISPR/Cas9-assisted homologous recombination. RESULTS: α1-Antitrypsin deficiency (AATD) is a monogenic heritable disease that often results in lungs and liver damage. Current augmentation therapy is expensive and in short of supply. To develop a safer and more effective therapeutic strategy for AATD, we integrated the AAT gene (SERPINA1, NG_008290.1) into the AAVS1 locus of human cell line HEK293T and assessed the safety and efficacy of CRISPR/Cas9 on producing potential therapeutic cell lines...
July 18, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28715782/approach-and-avoidance-tendencies-in-depression-and-anxiety-disorders
#3
Sascha Y Struijs, Femke Lamers, Maartje S Vroling, Karin Roelofs, Philip Spinhoven, Brenda W J H Penninx
Anxiety is linked to increased avoidance and inhibition, whereas depression is linked to decreased approach and diminished behavioral activation. Although these notions are widely recognized, systematic investigation of approach-avoidance tendencies is lacking across these diagnostic groups. Participants (mean age = 45.6; 65.8% female) were subdivided in healthy controls (405), remitted patients (877) and currently anxious (217), depressed (154) or comorbid (154) patients. Automatic approach-avoidance tendencies in reaction to facial expression were assessed using the Approach-Avoidance-Task (AAT)...
July 5, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28712822/association-study-of-hnf1a-polymorphisms-with-metabolic-syndrome-in-the-moroccan-population
#4
Imane Morjane, Rym Kefi, Hicham Charoute, Fouzia Lakbakbi El Yaagoubi, Meryem Hechmi, Rachid Saile, Sonia Abdelhak, Abdelhamid Barakat
AIMS: Variants in Hepatocyte Nuclear Factor 1 alpha (HNF1A) gene are associated with Metabolic Syndromeand its components independently. In this study, we aimed to assess the statistical association of the rs1169288, rs2464196 and rs735396 variants and haplotypes of HNF1A gene with metabolic syndrome (MS) and its components in a Moroccan population sample. METHODS: Three variants in the HNF1A gene were genotyped, rs1169288 A>C, rs2464196 G>A and rs735396 T>C in cases and controls from Moroccan population using KASPar(®) technology (KBioscience, UK)...
July 3, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28710348/spatiotemporal-expression-patterns-of-wheat-amino-acid-transporters-reveal-their-putative-roles-in-nitrogen-transport-and-responses-to-abiotic-stress
#5
Yongfang Wan, Robert King, Rowan A C Mitchell, Keywan Hassani-Pak, Malcolm J Hawkesford
Amino acid transporters have roles in amino acid uptake from soil, long-distance transport, remobilization from vegetative tissues and accumulation in grain. Critically, the majority of wheat grain nitrogen is derived from amino acids remobilized from vegetative organs. However, no systematic analysis of wheat AAT genes has been reported to date. Here, 283 full length wheat AAT genes representing 100 distinct groups of homeologs were identified and curated by selectively consolidating IWGSC CSSv2 and TGACv1 Triticum aestivum genome assemblies and reassembling or mapping of IWGSC CSS chromosome sorted reads to fill any gaps...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28699394/stepping-out-of-the-shadows-of-alzheimer-s-disease-a-phenomenological-hermeneutic-study-of-older-people-with-alzheimer-s-disease-caring-for-a-therapy-dog
#6
Anna Swall, Britt Ebbeskog, Carina Lundh Hagelin, Ingegerd Fagerberg
PURPOSE: Living with Alzheimer's disease (AD) can involve a person being unable to recall and convey information in daily life. There are several ways to provide person-centred care to older people with AD, e.g. by empowering them in a situation. The use of animal-assisted therapy (AAT) with a therapy dog in the care of people with dementia is increasing, with the presence of a therapy dog being described as improving, among other things, the well-being and socialization of the person...
December 2017: International Journal of Qualitative Studies on Health and Well-being
https://www.readbyqxmd.com/read/28681700/meta-analysis-without-study-specific-variance-information-heterogeneity-case
#7
Patarawan Sangnawakij, Dankmar Böhning, Sa-Aat Niwitpong, Stephen Adams, Michael Stanton, Heinz Holling
The random effects model in meta-analysis is a standard statistical tool often used to analyze the effect sizes of the quantity of interest if there is heterogeneity between studies. In the special case considered here, meta-analytic data contain only the sample means in two treatment arms and the sample sizes, but no sample standard deviation. The statistical comparison between two arms for this case is not possible within the existing meta-analytic inference framework. Therefore, the main objective of this paper is to estimate the overall mean difference and associated variances, the between-study variance and the within-study variance, as specified as the important elements in the random effects model...
January 1, 2017: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/28679527/ornithine-uptake-and-the-modulation-of-drug-sensitivity-in-trypanosoma-brucei
#8
Juan P Macedo, Rachel B Currier, Corina Wirdnam, David Horn, Sam Alsford, Doris Rentsch
Trypanosoma brucei, protozoan parasites that cause human African trypanosomiasis (HAT), depend on ornithine uptake and metabolism by ornithine decarboxylase (ODC) for survival. Indeed, ODC is the target of the WHO "essential medicine" eflornithine, which is antagonistic to another anti-HAT drug, suramin. Thus, ornithine uptake has important consequences in T. brucei, but the transporters have not been identified. We describe these amino acid transporters (AATs). In a heterologous expression system, TbAAT10-1 is selective for ornithine, whereas TbAAT2-4 transports both ornithine and histidine...
July 5, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28675116/acute-alcohol-effects-on-explicit-and-implicit-motivation-to-drink-alcohol-in-socially-drinking-adolescents
#9
Elisabeth Jünger, Amir-Homayoun Javadi, Corinde E Wiers, Christian Sommer, Maria Garbusow, Nadine Bernhardt, Sören Kuitunen-Paul, Michael N Smolka, Ulrich S Zimmermann
Alcohol-related cues can evoke explicit and implicit motivation to drink alcohol. Concerning the links between explicit and implicit motivation, there are mixed findings. Therefore, we investigated both concepts in 51 healthy 18- to 19-year-old males, who are less affected by neuropsychological deficits in decision-making that are attributed to previous alcohol exposure than older participants. In a randomized crossover design, adolescents were infused with either alcohol or placebo. Self-ratings of alcohol desire, thirst, well-being and alcohol effects comprised our explicit measures of motivation...
July 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28668972/a-new-serpina-1-missense-mutation-associated-with-alpha-1-antitrypsin-deficiency-and-bronchiectasis
#10
G E Carpagnano, R Santacroce, G A Palmiotti, A Leccese, E Giuffreda, M Margaglione, M P Foschino Barbaro, S Aliberti, D Lacedonia
Alpha-1-antitrypsin deficiency (AATD) is a genetic condition caused by SERPINA1 mutations, which culminates into lower protease inhibitor activity in the serum and predisposes to emphysema. Clinical manifestations of AATD are often associated to ZZ (p.Glu342Lys) and SZ (p.Glu264Val) genotypes and less frequently to rare deficiency or null alleles in heterozygous and homozygous states. We report a case of a 52-year-old woman with bronchiectasis without other potential causes other than an electrophoresis that showed a decrease of alpha-1 globin band and AAT levels below the normal value (78 mg/dl; v...
July 1, 2017: Lung
https://www.readbyqxmd.com/read/28668763/vascular-mimicry-a-novel-neovascularization-mechanism-driving-anti-angiogenic-therapy-aat-resistance-in-glioblastoma
#11
REVIEW
Kartik Angara, Thaiz F Borin, Ali S Arbab
Glioblastoma (GBM) is a hypervascular neoplasia of the central nervous system with an extremely high rate of mortality. Owing to its hypervascularity, anti-angiogenic therapies (AAT) have been used as an adjuvant to the traditional surgical resection, chemotherapy, and radiation. The benefits of AAT have been transient and the tumors were shown to relapse faster and demonstrated particularly high rates of AAT therapy resistance. Alternative neovascularization mechanisms were shown to be at work in these resilient tumors to counter the AAT therapy insult...
June 29, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28655999/genome-wide-identification-and-expression-analysis-of-amino-acid-transporters-in-the-whitefly-bemisia-tabaci-gennadius
#12
Jixing Xia, Zezhong Yang, Cheng Gong, Wen Xie, Huipeng Pan, Zhaojiang Guo, Huixin Zheng, Xin Yang, Xiaodong Sun, Shi Kang, Fengshan Yang, Qingjun Wu, Shaoli Wang, Bin Cong, Xianfeng Teng, Youjun Zhang
The whitefly (Bemisia tabaci) is a cosmopolitan and devastating pest of agricultural crops and ornamentals. B. tabaci causes extensive damage by feeding on phloem and by transmitting plant viruses. Like many other organisms, insects depend on amino acid transporters (AATs) to transport amino acids into and out of its cells. We present a genome-wide and transcriptome-wide investigation of the following two families of AATs in B. tabaci biotype B: amino acid/auxin permease (AAAP) and amino acid/polyamine/organocation (APC)...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28655350/serum-biochemical-parameters-and-cytokine-profiles-associated-with-natural-african-trypanosome-infections-in-cattle
#13
Soale Majeed Bakari, Jennifer Afua Ofori, Kwadwo Asamoah Kusi, George Kwame Aning, Gordon Akanzuwine Awandare, Mark Carrington, Theresa Manful Gwira
BACKGROUND: Animal African trypanosomiasis (AAT) greatly affects livestock production in sub-Saharan Africa. In Ghana prevalence of AAT is estimated to range between 5 and 50%. Studies have reported serum biochemical aberrations and variability in cytokine profiles in animals during infection. However, information regarding the biochemical parameters and cytokine profiles associated with natural infections are limited. This study was therefore aimed at investigating changes in the levels of serum biochemical parameters and inflammatory cytokines during a natural infection...
June 27, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28652721/alpha-1-antitrypsin-pi-sz-genotype-estimated-prevalence-and-number-of-sz-subjects-worldwide
#14
Ignacio Blanco, Patricia Bueno, Isidro Diego, Sergio Pérez-Holanda, Beatriz Lara, Francisco Casas-Maldonado, Cristina Esquinas, Marc Miravitlles
The alpha-1 antitrypsin (AAT) haplotype Pi*S, when inherited along with the Pi*Z haplotype to form a Pi*SZ genotype, can be associated with pulmonary emphysema in regular smokers, and less frequently with liver disease, panniculitis, and systemic vasculitis in a small percentage of people, but this connection is less well established. Since the detection of cases can allow the application of preventive measures in patients and relatives with this congenital disorder, the objective of this study was to update the prevalence of the SZ genotype to achieve accurate estimates of the number of Pi*SZ subjects worldwide, based on studies performed according to the following criteria: 1) samples representative of the general population, 2) AAT phenotyping characterized by adequate methods, and 3) selection of studies with reliable results assessed with a coefficient of variation calculated from the sample size and 95% confidence intervals...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28635345/avatar-assisted-therapy-a-proof-of-concept-pilot-study-of-a-novel-technology-based-intervention-to-treat-substance-use-disorders
#15
Michael S Gordon, Steven B Carswell, Mary Schadegg, Kayla Mangen, Kelly Merkel, Susan Tangires, Frank J Vocci
BACKGROUND: Avatar-assisted therapy (AAT) is a novel and emerging technology that uses the Internet to enable clinicians and clients in substance abuse treatment to participate in group counseling sessions from separate and remote locations in real time through the use of avatars and virtual environments. OBJECTIVES: The current study is a pilot proof-of-concept feasibility study involving individuals in outpatient substance abuse treatment. This report addresses two questions: (1) are individuals who present for substance abuse treatment interested in receiving AAT and (2) what factors are associated with better treatment success...
September 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28625042/selenium-status-and-fungi-in-the-protein-losing-enteropathy-of-persistent-diarrhea
#16
Pramita G Dwipoerwantoro, Widjaja Lukito, Diana Aulia, Josiane Arnaud, Anne-Marie Roussel
BACKGROUND AND OBJECTIVES: A vicious cycle of infection, malabsorption, and malnutrition has been implicated in the perpetuation of diarrheal disease. This study examined whether persistent diarrhea is associated with changes in selenium status and stool alpha-1 antitrypsin (AAT) concentration. METHODS AND STUDY DESIGN: This cross-sectional study included 30 children aged 1-12 years with persistent diarrhea who were hospitalized in Cipto Mangunkusumo Hospital and Fatmawati Hospital, Jakarta, and 30 apparently healthy children who were matched by age and sex and lived in a rural area of Jakarta...
June 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28613191/collective-behaviors-of-mobile-robots-beyond-the-nearest-neighbor-rules-with-switching-topology
#17
Boda Ning, Qing-Long Han, Zongyu Zuo, Jiong Jin, Jinchuan Zheng
This paper is concerned with the collective behaviors of robots beyond the nearest neighbor rules, i.e., dispersion and flocking, when robots interact with others by applying an acute angle test (AAT)-based interaction rule. Different from a conventional nearest neighbor rule or its variations, the AAT-based interaction rule allows interactions with some far-neighbors and excludes unnecessary nearest neighbors. The resulting dispersion and flocking hold the advantages of scalability, connectivity, robustness, and effective area coverage...
June 8, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28609941/mitochondrial-genome-of-i-abraxas-i-i-suspecta-i-lepidoptera-geometridae-%C3%A2-and-comparative-analysis-with-other-lepidopterans
#18
Y U Sun, Jiawei Zhang, Qingqing Li, Dan Liang, Muhammad Nadeem Abbas, Cen Qian, Lei Wang, Guoqing Wei, Bao-Jian Zhu, Chao-Liang Liu
In this study, a complete mitochondrial genome (mitogenome) sequence of Abraxas suspecta (Lepidoptera: Geometridae) is isolated and characterized. The complete DNA is 15,547 bp length and contains 2 ribosomal RNA genes, 23 putative transfer RNA (tRNA) genes including an extra tRNAAsn (AUU), 13 protein-coding genes and an adenine (A) + thymine (T)-rich region. The nucleotide composition and gene organization are identical to those of other lepidopteran, except for the presence of an extra copy of trnN (AUU)...
April 20, 2017: Zootaxa
https://www.readbyqxmd.com/read/28608183/acc-aats-aha-ase-asnc-scai-scct-sts-2017-appropriate-use-criteria-for-coronary-revascularization-in-patients-with-stable-ischemic-heart-disease-a-report-of-the-american-college-of-cardiology-appropriate-use-criteria-task-force-american-association-for-thoracic
#19
Manesh R Patel, John H Calhoon, Gregory J Dehmer, James Aaron Grantham, Thomas M Maddox, David J Maron, Peter K Smith
The American College of Cardiology, Society for Cardiovascular Angiography and Interventions, Society of Thoracic Surgeons, and American Association for Thoracic Surgery, along with key specialty and subspecialty societies, have completed a 2-part revision of the appropriate use criteria (AUC) for coronary revascularization. In prior coronary revascularization AUC documents, indications for revascularization in acute coronary syndromes and stable ischemic heart disease (SIHD) were combined into 1 document. To address the expanding clinical indications for coronary revascularization, and to align the subject matter with the most current American College of Cardiology/American Heart Association guidelines, the new AUC for coronary artery revascularization were separated into 2 documents addressing SIHD and acute coronary syndromes individually...
June 12, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28604217/assisted-therapy-with-dogs-is-an-effective-tool
#20
(no author information available yet)
Cases of animal-assisted therapy (AAT) have been documented as far back as 1869, when Florence Nightingale used it with her patients ( Goddard and Gilmer 2015 ).
June 12, 2017: Nursing Children and Young People
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