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Animal assisted therapy

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https://www.readbyqxmd.com/read/29764282/animal-assisted-therapy-in-elderly-patients-evidence-and-controversies-in-dementia-and-psychiatric-disorders-and-future-perspectives-in-other-neurological-diseases
#1
Silvio Peluso, Anna De Rosa, Natascia De Lucia, Antonella Antenora, Maddalena Illario, Marcello Esposito, Giuseppe De Michele
Animal-assisted therapy (AAT) includes a set of nonpharmacological interventions aimed at improving human health through the use of trained or untrained animals. In recent decades, AAT has been trialed for different neurological and psychiatric disorders. In patients with dementia, interaction with animals seems to have a positive influence on aggressiveness and anxiety and to ameliorate quality of life and relationship skills. In psychiatric patients, AAT seems to increase motivation and self-esteem, improve prosocial conduct, and decrease behavioral problems...
January 1, 2018: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/29699406/nature-based-interventions-in-institutional-and-organisational-settings-a-scoping-review
#2
Chris Moeller, Nigel King, Viv Burr, Graham R Gibbs, Tim Gomersall
The objective of this review was to scope the literature on nature-based interventions that could be conducted in institutional settings where people reside full-time for care or rehabilitation purposes. Systematic searches were conducted across CINAHL, Medline, Criminal Justice Abstracts, PsycINFO, Scopus, Social Care Online and Cochrane CENTRAL. A total of 85 studies (reported in 86 articles) were included. Four intervention modalities were identified: Gardening/therapeutic horticulture; animal-assisted therapies; care farming and virtual reality-based simulations of natural environments...
April 26, 2018: International Journal of Environmental Health Research
https://www.readbyqxmd.com/read/29695767/cutaneous-neurofibromas-in-the-genomics-era-current-understanding-and-open-questions
#3
REVIEW
Robert J Allaway, Sara J C Gosline, Salvatore La Rosa, Pamela Knight, Annette Bakker, Justin Guinney, Lu Q Le
Cutaneous neurofibromas (cNF) are a nearly ubiquitous symptom of neurofibromatosis type 1 (NF1), a disorder with a broad phenotypic spectrum caused by germline mutation of the neurofibromatosis type 1 tumour suppressor gene (NF1). Symptoms of NF1 can include learning disabilities, bone abnormalities and predisposition to tumours such as cNFs, plexiform neurofibromas, malignant peripheral nerve sheath tumours and optic nerve tumours. There are no therapies currently approved for cNFs aside from elective surgery, and the molecular aetiology of cNF remains relatively uncharacterised...
April 26, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29694525/-the-use-of-animal-assisted-therapy-a-bioethical-question
#4
Marta Luciane Fischer, Maria Fernanda Turbay Palodeto, Erica Costa Dos Santos
This paper addresses ethical questions concerning animal-assisted therapy (zootherapy). While it has been documented for centuries in several cultures and is resistant to urban and technological developments, it combines multiple moral and vulnerable agents, constituting a dilemma whose fair and consensual solution calls for new perspectives, like environmental bioethics. Through analyses of scientific texts, the arguments and values intrinsic to decisions about how and when to use animals as medical resources are systematized...
March 2018: História, Ciências, Saúde—Manguinhos
https://www.readbyqxmd.com/read/29671416/pharmacological-approaches-promoting-stem-cell-based-therapy-following-ischemic-stroke-insults
#5
REVIEW
Shu-Zhen Zhu, Vivian Szeto, Mei-Hua Bao, Hong-Shuo Sun, Zhong-Ping Feng
Stroke can lead to long-term neurological deficits. Adult neurogenesis, the continuous generation of newborn neurons in distinct regions of the brain throughout life, has been considered as one of the appoaches to restore the neurological function following ischemic stroke. However, ischemia-induced spontaneous neurogenesis is not suffcient, thus cell-based therapy, including infusing exogenous stem cells or stimulating endogenous stem cells to help repair of injured brain, has been studied in numerous animal experiments and some pilot clinical trials...
April 19, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29668896/critical-review-of-research-methods-used-to-consider-the-impact-of-human-animal-interaction-on-older-adults-health
#6
Erika Friedmann, Nancy R Gee
Background and Objectives: Most research on human-animal interaction (HAI) and human health focuses on one of three perspectives: (a) health effects of pet ownership; (b) health effects of contact with a companion animal; or (c) health effects of animal-assisted interventions including animal-assisted therapies, and animal-assisted activities. Methods: We reviewed research methods used to address each perspective, within the context of human aging, and identified challenges associated with these methods...
April 12, 2018: Gerontologist
https://www.readbyqxmd.com/read/29659063/parents-acceptance-and-their-children-s-choice-of-pet-for-animal-assisted-therapy-a-a-t-in-3-to-12-year-old-children-in-the-dental-operatory-a-questionnaire-based-pilot-study
#7
Nidhi Gupta, Tushar Yadav
AIM: To evaluate the parents' acceptance to therapy pets, child's most favoured pet, child's choice of soft toy as compared to live pet, and child's preference of his own pet versus therapy pet. METHODS: Sixty-two children of age groups 3-6 year, 6-9 year, and 9-12 year were selected. The data from completed questionnaires were statistically analysed and subjected to z test, Chi-squared test with P value<0.05 considered as significant. RESULTS: The consent to the presence of pet was given by 41...
April 16, 2018: International Journal of Paediatric Dentistry
https://www.readbyqxmd.com/read/29621141/correcting-calcium-dysregulation-in-chronic-heart-failure-using-serca2a-gene-therapy
#8
REVIEW
T Jake Samuel, Ryan P Rosenberry, Seungyong Lee, Zui Pan
Chronic heart failure (CHF) is a major contributor to cardiovascular disease and is the leading cause of hospitalization for those over the age of 65, which is estimated to account for close to seventy billion dollars in healthcare costs by 2030 in the US alone. The successful therapies for preventing and reversing CHF progression are urgently required. One strategy under active investigation is to restore dysregulated myocardial calcium (Ca2+ ), a hallmark of CHF. It is well established that intracellular Ca2+ concentrations are tightly regulated to control efficient myocardial systolic contraction and diastolic relaxation...
April 5, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29619213/pet-owner-and-vet-interactions-exploring-the-drivers-of-amr
#9
Matt Smith, Caroline King, Mark Davis, Adele Dickson, Jeni Park, Fraser Smith, Kay Currie, Paul Flowers
Background: Antimicrobial resistance (AMR) is a growing public health problem across the world. As the negative consequences of AMR become apparent at local, national and international levels, more attention is being focussed on the variety of mechanisms by which AMR is potentiated. We explore how interactions between pet owners and veterinarians represent a key arena in which AMR-related behaviours can be shaped. Methods: In depth semi-structured interviews were carried out with pet owners ( n  = 23) and vets ( n  = 16) across the UK in 2017...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29617398/impact-of-an-animal-assisted-therapy-programme-on-physiological-and-psychosocial-variables-of-paediatric-oncology-patients
#10
Nathiana B Silva, Flávia L Osório
The objective of this study was to propose an intervention and safety protocol for performing animal-assisted therapy (AAT) and evaluating its efficacy in children under outpatient oncological treatment based on psychological, physiological, and quality of life indicators for the children and caregivers. The sample consisted of 24 children diagnosed with leukaemia and solid tumours (58% girls with a mean age of 8.0 years) who underwent an AAT programme consisting of three 30-min sessions in an open group. Two dogs (one Labrador retriever and one golden retriever) were used, and activities such as sensory stimulation, gait training, and socialization were conducted...
2018: PloS One
https://www.readbyqxmd.com/read/29563027/effect-of-a-robotic-seal-on-the-motor-activity-and-sleep-patterns-of-older-people-with-dementia-as-measured-by-wearable-technology-a-cluster-randomised-controlled-trial
#11
Wendy Moyle, Cindy Jones, Jenny Murfield, Lukman Thalib, Elizabeth Beattie, David Shum, Siobhan O'Dwyer, M Cindy Mervin, Brian Draper
OBJECTIVES: The robotic seal, PARO, has been used as an alternative to animal-assisted therapies with residents with dementia in long-term care, yet understanding of its efficacy is limited by a paucity of research. We explored the effects of PARO on motor activity and sleep patterns, as measured by a wearable triaxial accelerometer. STUDY DESIGN: Cluster-randomised controlled trial, involving 28 facilities in Queensland, Australia. Nine facilities were randomised to the PARO group (individual, non-facilitated, 15-min sessions three afternoons per week for 10 weeks), 10 to a plush toy (PARO with robotic features disabled) and nine to usual care...
April 2018: Maturitas
https://www.readbyqxmd.com/read/29562511/clinical-trials-for-disease-modifying-therapies-in-alzheimer-s-disease-a-primer-lessons-learned-and-a-blueprint-for-the-future
#12
Jeffrey Cummings, Aaron Ritter, Kate Zhong
Alzheimer's disease (AD) has no currently approved disease-modifying therapies (DMTs), and treatments to prevent, delay the onset, or slow the progression are urgently needed. A delay of 5 years if available by 2025 would decrease the total number of patients with AD by 50% in 2050. To meet the definition of DMT, an agent must produce an enduring change in the course of AD; clinical trials of DMTs have the goal of demonstrating this effect. AD drug discovery entails target identification followed by high throughput screening and lead optimization of drug-like compounds...
March 16, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29560432/altered-regulation-of-cardiac-ankyrin-repeat-protein-in-heart-failure
#13
Amber Kempton, Matt Cefalu, Cody Justice, Tesla Baich, Mohamed Derbala, Benjamin Canan, Paul M L Janssen, Peter J Mohler, Sakima A Smith
Background: Left ventricular assist devices (LVADs) have revolutionized and improved the care of the sickest heart failure (HF) patients, and it is imperative that they receive appropriate ventricular unloading. Assessing this critical parameter with current methodologies (labs, imaging) is usually suboptimal in this patient population. Hence it is imperative to elucidate the molecular underpinnings involved in ventricular unloading. We have previously identified the cytoskeletal protein βII spectrin as an essential nodal protein involved in post-translational targeting and βII spectrin protein levels are significantly altered in multiple forms of human and animal HF...
January 2018: Heliyon
https://www.readbyqxmd.com/read/29524515/mdma-assisted-psychotherapy-for-ptsd-are-memory-reconsolidation-and-fear-extinction-underlying-mechanisms
#14
REVIEW
Allison A Feduccia, Michael C Mithoefer
MDMA-assisted psychotherapy for treatment of PTSD has recently progressed to Phase 3 clinical trials and received Breakthrough Therapy designation by the FDA. MDMA used as an adjunct during psychotherapy sessions has demonstrated effectiveness and acceptable safety in reducing PTSD symptoms in Phase 2 trials, with durable remission of PTSD diagnosis in 68% of participants. The underlying psychological and neurological mechanisms for the robust effects in mitigating PTSD are being investigated in animal models and in studies of healthy volunteers...
June 8, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29520012/assisted-delivery-of-antisense-therapeutics-in-animal-models-of-heritable-neurodegenerative-and-neuromuscular-disorders-a-systematic-review-and-meta-analysis
#15
M Leontien van der Bent, Omar Paulino da Silva Filho, Judith van Luijk, Roland Brock, Derick G Wansink
Antisense oligonucleotide (AON)-based therapies hold promise for a range of neurodegenerative and neuromuscular diseases and have shown benefit in animal models and patients. Success in the clinic is nevertheless still limited, due to unfavourable biodistribution and poor cellular uptake of AONs. Extensive research is currently being conducted into the formulation of AONs to improve delivery, but thus far there is no consensus on which of those strategies will be the most effective. This systematic review was designed to answer in an unbiased manner which delivery strategies most strongly enhance the efficacy of AONs in animal models of heritable neurodegenerative and neuromuscular diseases...
March 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29510254/the-functionality-of-prebiotics-as-immunostimulant-evidences-from-trials-on-terrestrial-and-aquatic-animals
#16
REVIEW
Asad Nawaz, Allah Bakhsh Javaid, Sana Irshad, Seyed Hossein Hoseinifar, Hanguo Xiong
The gut immune system is, the main option for maintaining host's health, affected by numerous factors comprising dietary constituents and commensal bacteria. These dietary components that affect the intestinal immunity and considered as an alternative of antibiotics are called immunosaccharides. Fructooligosaccharide (FOS), Galactooligosaccharide (GOS), inulin, dietary carbohydrates, and xylooligosaccharide (XOS) are among the most studied prebiotics in human as well as in aquaculture. Although prebiotics and probiotics have revealed potential as treatment for numerous illnesses in both human and fish, a comprehensive understanding of the molecular mechanism behind direct and indirect effect on the intestinal immune response will help more and perhaps extra effective therapy intended for ailments...
May 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29471723/minimally-invasive-microneedle-array-extraction-of-interstitial-fluid-for-comprehensive-biomedical-applications-transcriptomics-proteomics-metabolomics-exosome-research-and-biomarker-identification
#17
Robert M Taylor, Philip R Miller, Parwana Ebrahimi, Ronen Polsky, Justin T Baca
Interstitial fluid (ISF) has recently garnered interest as a biological fluid that could be used as an alternate to blood for biomedical applications, diagnosis, and therapy. ISF extraction techniques are promising because they are less invasive and less painful than venipuncture. ISF is an alternative, incompletely characterized source of physiological data. Here, we describe a novel method of ISF extraction in rats, using microneedle arrays, which provides volumes of ISF that are sufficient for downstream analysis techniques such as proteomics, genomics, and extracellular vesicle purification and analysis...
January 1, 2018: Laboratory Animals
https://www.readbyqxmd.com/read/29444239/therapeutic-efficacy-of-microtube-embedded-chondroitinase-abc-in-a-canine-clinical-model-of-spinal-cord-injury
#18
Hilary Z Hu, Nicolas Granger, S Balakrishna Pai, Ravi V Bellamkonda, Nick D Jeffery
See Moon and Bradbury (doi:10.1093/brain/awy067) for a scientific commentary on this article.Many hundreds of thousands of people around the world are living with the long-term consequences of spinal cord injury and they need effective new therapies. Laboratory research in experimental animals has identified a large number of potentially translatable interventions but transition to the clinic is not straightforward. Further evidence of efficacy in more clinically-relevant lesions is required to gain sufficient confidence to commence human clinical trials...
April 1, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29412118/antibody-administration-for-bone-tissue-engineering-a-systematic-review
#19
Sepanta Hosseinpour, Maryam Rezai Rad, Arash Khojasteh, Homayoun H Zadeh
BACKGROUND: Currently, antibodies are progressively applied in medicine for different purposes, including diagnostic and therapeutic indications. Over twenty monoclonal antibodies utilized for many therapeutic reasons from therapy of cancers, immune disorders, and osteoporosis to localized bony defects. In addition, therapeutic antibodies represented various findings in bone tissue engineering. OBJECTIVES: The current study aims to systematically review the available literature on antibody assisted bone regeneration in animal models...
2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29401355/animal-assisted-therapy-for-post-traumatic-stress-disorder-lessons-from-case-reports-in-media-stories
#20
Eric L Altschuler
Post-traumatic stress disorder (PTSD) can follow war trauma, sexual abuse, other traumas, and even be experienced by commanders for the PTSD of their subordinates. Medications and counseling are sometimes not effective, so new treatments are needed. Some years ago, I suggested that animal-assisted therapy (AAT) (pet therapy) might be beneficial for PTSD. A large randomized controlled trial is underway of canine-assisted therapy for PTSD. Randomized controlled trials are most useful in assessing the efficacy of a medical intervention as these trials control for known and unknown biases...
January 1, 2018: Military Medicine
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