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https://www.readbyqxmd.com/read/29778514/conditional-admission-religious-exemption-type-and-nonmedical-vaccine-exemptions-in-california-before-and-after-a-state-policy-change
#1
Alison M Buttenheim, Malia Jones, Caitlin Mckown, Daniel Salmon, Saad B Omer
Recent measles and pertussis outbreaks in the US have focused national attention on state laws governing exemptions from mandatory vaccines for school entry. After several years of increases in nonmedical exemptions in California, the state assembly passed Assembly Bill 2109 in 2012, making nonmedical exemptions more difficult to obtain by requiring parents to obtain a signature from a health care provider. We used data from the California Department of Public Health to describe changes in the overall prevalence of personal belief exemptions and compositional changes in immunization status for the school years 2012-2013 through 2015-2016...
May 16, 2018: Vaccine
https://www.readbyqxmd.com/read/29777884/neurosurgical-management-of-self-inflicted-cranial-crossbow-injury
#2
Charles G Kulwin, Andrew DeNardo, Saad Khairi, Troy Payner
BACKGROUND: While gun-related penetrating traumatic brain injuries make up the majority of cranial missile injuries, low-velocity penetrating injuries present significant clinical difficulties that cannot necessarily be identically managed. Bow hunting is an increasingly popular pastime, and a crossbow allows a unique mechanism to cause a self-inflicted cranial injury with a large, low-velocity projectile. Historically, arrow removal is described in an operating room setting, which provides limited knowledge of the location of vascular injury in the setting of post-removal hemorrhage, and may represent an inefficient use of operating room availability...
May 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29773006/antimelanogenesis-and-anti-inflammatory-activity-of-selected-culinary-medicinal-mushrooms
#3
Hazwani Mat Saad, Kae Shin Sim, Yee Shin Tan
Five culinary-medicinal mushrooms are commonly available in the Malaysian market: Agaricus bisporus (white and brown), Ganoderma lucidum, Hypsizygus marmoreus, Pleurotus floridanus, and P. pulmonarius. These species were selected for use in the current study, the aim of which was to investigate the antimelanogenesis and anti-inflammatory activity of these mushrooms in an attempt to evaluate their potential use in cosmeceuticals. Mushroom fruiting bodies were extracted with hot water, and the extracts were freeze-dried before testing...
2018: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/29772566/the-epigenetic-factor-kdm2b-regulates-emt-and-small-gtpases-in-colon-tumor-cells
#4
Nefeli Zacharopoulou, Anna Tsapara, Galatea Kallergi, Evi Schmid, Saad Alkahtani, Saud Alarifi, Philip N Tsichlis, Sotirios C Kampranis, Christos Stournaras
BACKGROUND/AIMS: The epigenetic factor KDM2B is a histone demethylase expressed in various tumors. Recently, we have shown that KDM2B regulates actin cytoskeleton organization, small Rho GTPases signaling, cell-cell adhesion and migration of prostate tumor cells. In the present study, we addressed its role in regulating EMT and small GTPases expression in colon tumor cells. METHODS: We used RT-PCR for the transcriptional analysis of various genes, Western blotting for the assessment of protein expression and immunofluorescence microscopy for visualization of fluorescently labeled proteins...
May 14, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29772470/synthesis-molecular-docking-and-xanthine-oxidase-inhibitory-activity-of-5-aryl-1h-tetrazoles
#5
Itrat Fatima, Humaira Zafar, Khalid Mohammed Khan, Syed Muhammad Saad, Sumaira Javaid, Shahnaz Perveen, M Iqbal Choudhary
5-Aryl-1H-tetrazoles (1-24) were synthesized and screened for their xanthine oxidase (XO) inhibitory activity using allopurinol as standard inhibitor (IC50  = 2.0 ± 0.01 µM). Six compounds 3, 4, 5, 9, 21, and 24 exhibited significant to weak activities with IC50 values in the range of 7.4-174.2 µM. Active compounds were further subjected to kinetic and molecular docking studies to deduce their modes of inhibition, and to study their interactions with the protein (XO) at atomic level, respectively...
May 1, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29769384/meta-research-on-oncology-trials-a-toolkit-for-researchers-with-limited-resources
#6
Rachel P Riechelmann, Julien Péron, Bostjan Seruga, Everardo D Saad
"Meta-research" is a discipline that investigates research practices. Meta-research on clinical trials is an attempt to summarize descriptive and methodological features of published or ongoing clinical trials, including aspects of their implementation, design, analysis, reporting, and interpretation. In this type of investigation, the unit of analysis is a primary source of information about a clinical trial (e.g., published reports, study protocols, or abstracts), with meta-research being a second layer of information that summarizes what is known from various primary sources...
May 16, 2018: Oncologist
https://www.readbyqxmd.com/read/29765916/an-assessment-of-job-satisfaction-a-cross-sectional-study-among-orthodontists-of-saudi-arabia
#7
Nasser D Alqahtani, Khaled Alshehry, Saad Alateeq, Hammad Alturki, Sahar Albarakati, Moshabab A Asiry, Muhammad S Ahmedani
AIM OF THE STUDY: The main objective of the present study was to investigate the level of job satisfaction among professional orthodontists in relation to some significant intrinsic and extrinsic factors that generally affect their performance. MATERIALS AND METHODS: A cross-sectional study was conducted among orthodontists working in the Kingdom of Saudi Arabia using an online survey questionnaire through Survey Monkey. A total of 161 responses were received; among those, 57...
2018: Journal of Orthodontic Science
https://www.readbyqxmd.com/read/29765492/editorial-oxidative-stress-in-the-critically-ill-patients-pathophysiology-and-potential-interventions
#8
EDITORIAL
Demosthenes Makris, Peter R Mertens, Evangelia Dounousi, Gregory Giamouzis, Saad Nseir
No abstract text is available yet for this article.
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29765424/public-awareness-on-cord-blood-banking-in-saudi-arabia
#9
Dunia Jawdat, Sulaiman AlTwijri, Hadeel AlSemari, Mayssa Saade, Ahmed Alaskar
Background: In the last decade, cord blood (CB) has proven to be a valuable source of hematopoietic stem cells for transplantation to treat many hematological disorders. Since then, many CB banks have been established worldwide. Our aim was to estimate the level of public awareness of CB banking in Saudi Arabia. Study Design and Methods: A self-administered questionnaire of 22 multiple choices was conveniently distributed, consisting of demographics, awareness measure, attitude toward banking preference, and donation for research data...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29764892/intense-exercise-for-survival-among-men-with-metastatic-castrate-resistant-prostate-cancer-interval-gap4-a-multicentre-randomised-controlled-phase-iii-study-protocol
#10
Robert U Newton, Stacey A Kenfield, Nicolas H Hart, June M Chan, Kerry S Courneya, James Catto, Stephen P Finn, Rosemary Greenwood, Daniel C Hughes, Lorelei Mucci, Stephen R Plymate, Stephan F E Praet, Emer M Guinan, Erin L Van Blarigan, Orla Casey, Mark Buzza, Sam Gledhill, Li Zhang, Daniel A Galvão, Charles J Ryan, Fred Saad
INTRODUCTION: Preliminary evidence supports the beneficial role of physical activity on prostate cancer outcomes. This phase III randomised controlled trial (RCT) is designed to determine if supervised high-intensity aerobic and resistance exercise increases overall survival (OS) in patients with metastatic castrate-resistant prostate cancer (mCRPC). METHODS AND ANALYSIS: Participants (n=866) must have histologically documented metastatic prostate cancer with evidence of progressive disease on androgen deprivation therapy (defined as mCRPC)...
May 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29764775/predicting-round-window-visibility-during-cochlear-implantation-using-high-resolution-ct-scan
#11
Saad Elzayat, Mahmoud Mandour, Rasha Lotfy, Ali Mahrous
OBJECTIVES: To predict round window niche (RWN) visibility using high-resolution computed tomography (HRCT). MATERIALS AND METHODS: We retrospectively reviewed the pre-surgical axial HRCT scan of 110 patients who underwent cochlear implantation and compared the CT visibility of RWN with the intraoperative findings by reviewing the operative notes and replaying the surgical video recording. The shape of RWN was determined using the HRCT slice with maximum RWN visibility...
April 2018: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/29763420/knee-pain-and-health-related-quality-of-life-among-older-patients-with-different-knee-osteoarthritis-severity-in-saudi-arabia
#12
Saad M Bindawas, Vishal Vennu, Saud Alfhadel, Ali D Al-Otaibi, Ahmad S Binnasser
OBJECTIVE: There is a lack of knowledge about health-related quality of life (HRQoL) in Saudi patients with musculoskeletal impairment, particularly among older adult populations. Thus, the current research aimed to determine the association of knee osteoarthritis (OA) severity with knee pain (KP) and HRQoL among older patients in Riyadh, Saudi Arabia. METHODS: In a multicenter cross-sectional study, we recruited 209 consecutive males and females aged ≥55 years with radiographically diagnosed knee OA from five hospitals across Riyadh, Saudi Arabia...
2018: PloS One
https://www.readbyqxmd.com/read/29762188/the-reliability-of-radiostereometric-analysis-in-determining-physeal-motion-in-slipped-capital-femoral-epiphysis-in-standard-uniplanar-and-low-dose-eos-biplanar-radiography-a-phantom-model-study
#13
Jennifer K Hurry, Saad Rehan, Alan J Spurway, Elise K Laende, Janie L Astephen Wilson, Karl J Logan, Michael J Dunbar, Ron El-Hawary
Physeal closure after slipped capital femoral epiphysis fixation can be difficult to assess on two-dimensional conventional radiographs. Radiostereometric analysis offers improved motion detection over conventional radiography, whereas the EOS biplanar imager provides a means for low radiation weight-bearing images. This phantom study assessed the reliability of measuring motion using radiostereometric analysis in the EOS using a slipped capital femoral epiphysis model. The accuracy and precision were better than 0...
May 14, 2018: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/29761756/evaluation-of-standard-and-mobile-health-supported-clinical-diagnostic-tools-for-assessing-dehydration-in-patients-with-diarrhea-in-rural-bangladesh
#14
Saadiyah Bilal, Eric Nelson, Lars Meisner, Mahfuj Alam, Saad Al Amin, Yokabed Ashenafi, Shivani Teegala, Md Khan, Nur Alam, Adam Levine
Diarrhea remains a leading cause of morbidity and mortality in patients worldwide. The objective of this study was to determine the relative inter-rater reliability and usability of standard and Mobile health (mHealth)-supported World Health Organization (WHO) algorithms for dehydration assessment in patients with acute diarrhea in a rural, low-income country hospital. Two nurses blinded to each other's examinations assessed dehydration status on patients soon after hospital arrival using either the standard WHO algorithm printed on a laminated card or an mHealth-supported WHO algorithm downloaded onto a smartphone...
May 14, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29760586/atorvastatin-and-diacerein-reduce-insulin-resistance-and-increase-disease-tolerance-in-rats-with-sepsis
#15
K L C da Silva, A P Camacho, F C Mittestainer, B M Carvalho, A Santos, D Guadagnini, A G Oliveira, M J A Saad
Background: Sepsis is one of the leading causes of death among hospitalized patients. At the onset of this condition, there is an over-production of pro-inflammatory mediators that contribute to organ failure and death. The excess production of pro-inflammatory mediators also impairs insulin signaling, which may be a pathophysiological tissue marker of proinflammatory cytokine action before organ failure. Statins and diacerein have pleiotropic effects, such as the blockage of inflammatory signaling pathways, suggesting that these drugs may be an attractive therapeutic or prophylactic strategy against sepsis...
2018: Journal of Inflammation
https://www.readbyqxmd.com/read/29759807/predicting-patterns-of-disaster-related-resiliency-among-older-adult-typhoon-haiyan-survivors
#16
Joseph U Almazan, Jonas Preposi Cruz, Majed Sulaiman Alamri, Jazi Shaydied Monahi Alotaibi, Abdulrhman Saad B Albougami, Rotacio Gravoso, Ferdinand Abocejo, Kelly Allen, Ghose Bishwajit
Reported natural disasters are steadily increasing, yet there is limited previous research explicitly exploring the predictors of disaster resiliency among older people from typhoon-hit provinces. This study examined the relationships between life satisfaction, attitude, spirituality and locus of control towards resiliency among older adult Typhoon Haiyan survivors. A descriptive correlational design was conducted among these survivors in the Eastern Philippines. Standard multiple linear regression analysis was used in the study...
May 11, 2018: Geriatric Nursing
https://www.readbyqxmd.com/read/29759540/incidence-predictors-and-outcomes-of-early-atrial-arrhythmias-after-lung-transplant-a-systematic-review-and-meta-analysis
#17
Marwan Saad, Islam Y Elgendy, Amgad Mentias, Hesham K Abdelaziz, Amr F Barakat, Ahmed Abuzaid, Akram Y Elgendy, Mohammad K Mojadidi, Satish Chandrashekaran, Ahmed N Mahmoud
OBJECTIVES: This study sought to determine the incidence, predictors, and prognostic implications of early post-lung transplant atrial arrhythmias (AAs). BACKGROUND: Although frequently encountered, the prognostic implications of early AAs after lung transplant remain uncertain. METHODS: A systematic review of MEDLINE and the Cochrane Library was conducted for all studies that reported early post-lung transplant AAs. Random-effects DerSimonian-Laird risk ratios (RRs) were calculated for categorical variables and standardized mean difference (SMD) for continuous variables...
July 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29756582/polypharmacology-approach-against-migraine-with-aura-and-brain-edema-for-the-development-of-an-efficient-inhibitor-and-its-analogues
#18
Samawia Rizwan, Asim Mehmood, Irum Khalid, Muhammad Saad Khan, Qudsia Yousafi, Hayssam M Ali, Mohamed S Elshikh, Saima Kalsoom, Hamid Rashid
Polypharmacology is a design or use of pharmaceutical agents in which single drug is used to treat multiple diseases. Aquaporin proteins are identified to treat migraine with aura and brain edema. This study focuses on Aquaporin-1 and Aquaporin-4. AQP-1 is expressed in small afferent sensory nerve fibers. Over-expression of peripheral nervous system causes migraine. AQP-4 is an abundant channel water protein in brain that regulates water transport to prevent homeostasis. Over-expression of AQP-4 contributes to water imbalance in ischemic pathology resulting in cerebral edema...
May 13, 2018: Current Computer-aided Drug Design
https://www.readbyqxmd.com/read/29755532/transcutaneous-bilirubin-measurements-can-be-used-to-measure-bilirubin-levels-during-phototherapy
#19
Saad Abdullah Alsaedi
Objective: To determine whether transcutaneous bilirubin measurements (TcB) before and during phototherapy taken from covered skin during phototherapy correlate with total serum bilirubin (TSB) levels. Study Design: In this prospective observational study, healthy term newborns who required TSB measurements were included. TcB measurements were taken from the forehead before starting and during phototherapy using the BiliChek device. Before starting phototherapy, part of the forehead was covered...
2018: International Journal of Pediatrics
https://www.readbyqxmd.com/read/29752082/pvc-membrane-coated-wire-and-carbon-paste-ion-selective-electrodes-for-potentiometric-determination-of-galantamine-hydrobromide-in-physiological-fluids
#20
Fatehy M Abdel-Haleem, Mohamed Saad, Ahmed Barhoum, Mikhael Bechelany, Mahmoud S Rizk
We report on highly-sensitive ion-selective electrodes (ISEs) for potentiometric determining of galantamine hydrobromide (GB) in physiological fluids. Galantamine hydrobromide (GB) was selected for this study due to its previous medical importance for treating Alzheimer's disease. Three different types of ISEs were investigated: PVC membrane electrode (PVCE), carbon-paste electrode (CPE), and coated-wire electrode (CWE). In the construction of these electrodes, galantaminium-reineckate (GR) ion-pair was used as a sensing species for GB in solutions...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
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