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https://www.readbyqxmd.com/read/28221367/transcriptomic-analyses-and-leukocyte-telomere-length-measurement-in-subjects-exposed-to-severe-recent-stressful-life-events
#1
N Lopizzo, S Tosato, V Begni, S Tomassi, N Cattane, M Barcella, G Turco, M Ruggeri, M A Riva, C M Pariante, A Cattaneo
Stressful life events occurring in adulthood have been found able to affect mood and behavior, thus increasing the vulnerability for several stress-related psychiatric disorders. However, although there is plenty of clinical data supporting an association between stressful life events in adulthood and an enhanced vulnerability for psychopathology, the underlying molecular mechanisms are still poorly investigated. Thus, in this study we performed peripheral/whole-genome transcriptomic analyses in blood samples obtained from 53 adult subjects characterized for recent stressful life events occurred within the previous 6 months...
February 21, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28219886/dependence-of-glomerulonephritis-induction-on-novel-intraglomerular-alternatively-activated-bone-marrow-derived-macrophages-and-mac-1-and-pd-l1-in-lupus-prone-nzm2328-mice
#2
Sun-Sang J Sung, Yan Ge, Chao Dai, Hongyang Wang, Shu Man Fu, Rahul Sharma, Young S Hahn, Jing Yu, Thu H Le, Mark D Okusa, Warren K Bolton, Jessica R Lawler
Glomerular damage mediated by glomerulus-infiltrating myeloid-derived cells is a key pathogenic event in lupus nephritis (LN), but the process is poorly understood. Confocal microscopy of kidney sections and flow cytometry analysis of glomerular cells from magnetic bead-purified glomeruli have identified glomerulus-infiltrating leukocyte populations in NZM2328 (NZM) lupus-prone mice with spontaneous chronic glomerulonephritis (GN) and anti-glomerular basement membrane-induced nephritis. The occurrence of a major glomerulus-infiltrating CD11b(+)F4/80(-)I-A(-) macrophage population exhibiting the markers programmed death ligand-1 (PD-L1), Mac-2, and macrophage mannose receptor (CD206) and producing Klf4, Il10, Retnla, Tnf, and Il6 mRNA, which are known to be expressed by alternatively activated (M2b) macrophages, correlated with proteinuria status...
February 20, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28210842/uric-acid-as-a-novel-biomarker-for-bone-marrow-function-and-incipient-hematopoietic-reconstitution-after-aplasia-in-patients-with-hematologic-malignancies
#3
Sebastian P Haen, Vicky Eyb, Nora Mirza, Aline Naumann, Andreas Peter, Markus W Löffler, Christoph Faul, Wichard Vogel, Wolfgang A Bethge, Hans-Georg Rammensee, Lothar Kanz, Martin Heni
PURPOSE: Prolonged aplasia and graft failure (GF) represent life-threatening complications after hematopoietic cell transplantation (HCT) requiring suitable biomarkers for early detection and differentiation between GF and poor graft function (PGF). Uric acid (UA) is a strong immunological danger signal. METHODS: Laboratory results were analyzed from patients undergoing either allogeneic or autologous HCT or induction chemotherapy for acute leukemia (n = 50 per group, n = 150 total)...
February 16, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28202073/distinct-patterns-and-prognostic-values-of-tumor-infiltrating-macrophages-in-hepatocellular-carcinoma-and-gastric-cancer
#4
Jin-Qing Li, Xing-Juan Yu, Yong-Chun Wang, Li-Yun Huang, Chao-Qun Liu, Limin Zheng, Yu-Jing Fang, Jing Xu
BACKGROUND: Macrophages (Mφs) constitute a major component of the leukocyte infiltrate and perform distinct roles in different tumor microenvironments. This study aimed to characterize the distribution, composition and prognostic value of Mφs in hepatocellular carcinoma (HCC) and gastric cancer (GC). METHODS: Immunohistochemistry and immunofluorescence were used to identify Mφ subsets in HCC and GC tissues. Kaplan-Meier analysis and Cox regression models were applied to estimate the overall survival (OS) for HCC and GC patients...
February 15, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28186106/impact-of-dehydroepiandrosterone-sulfate-on-newborn-leukocyte-telomere-length
#5
Han Liu, Guangdi Zhou, Qian Chen, Fengxiu Ouyang, Julian Little, Jun Zhang, Dan Chen
The newborn setting of leukocyte telomere length (LTL) likely has important implications for telomere dynamics over the lifespan. However, its determinants are poorly understood. Hormones play an important role during pregnancy and delivery. We hypothesized that exposure to hormones may impact the fetal telomere biology system. To test this hypothesis, cortisol, estradiol, dehydroepiandrosterone sulfate (DHEAS) and reactive oxygen species (ROS) were measured in cord blood of 821 newborns from a prospective study...
February 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28167044/hypoxia-directs-human-extravillous-trophoblast-differentiation-in-a-hypoxia-inducible-factor-dependent-manner
#6
Anna K Wakeland, Francesca Soncin, Matteo Moretto-Zita, Ching-Wen Chang, Mariko Horii, Don Pizzo, Katharine K Nelson, Louise C Laurent, Mana M Parast
Villous cytotrophoblasts are epithelial stem cells of the early human placenta, able to differentiate either into syncytiotrophoblasts in floating chorionic villi or extravillous trophoblasts (EVTs) at the anchoring villi. The signaling pathways regulating differentiation into these two lineages are incompletely understood. The bulk of placental growth and development in the first trimester occurs under low oxygen tension. One major mechanism by which oxygen regulates cellular function is through the hypoxia-inducible factor (HIF), a transcription factor complex stabilized under low oxygen tension to mediate cellular responses, including cell fate decisions...
February 3, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28161186/a-dairy-herd-level-study-of-postpartum-diseases-and-their-association-with-reproductive-performance-and-culling
#7
J Dubuc, J Denis-Robichaud
The objectives of this study were to quantify the herd-level prevalence of postpartum diseases in a large number of dairy farms, and to identify prevalence alarm levels of these diseases based on association with a low prevalence of success at first service, with a high prevalence of pregnancy loss following pregnancy diagnosis at first service, and with a high prevalence of postpartum culling. A total of 126 commercial dairy herds were enrolled in this cohort study, and the herd was the unit of interest. Twenty cows from every herd were enrolled during the study period (a total of 2,520 lactating cows in the study)...
February 1, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28159208/the-importance-of-human-milk-for-immunity-in-preterm-infants
#8
REVIEW
Erin D Lewis, Caroline Richard, Bodil M Larsen, Catherine J Field
The immune system of preterm infants is immature, placing them at increased risk for serious immune-related complications. Human milk provides a variety of immune protective and immune maturation factors that are beneficial to the preterm infant's poorly developed immune system. The most studied immune components in human milk include antimicrobial proteins, maternal leukocytes, immunoglobulins, cytokines and chemokines, oligosaccharides, gangliosides, nucleotides, and long-chain polyunsaturated fatty acids...
March 2017: Clinics in Perinatology
https://www.readbyqxmd.com/read/28154163/less-than-ideal-cardiovascular-health-is-associated-with-shorter-leukocyte-telomere-length-the-national-health-and-nutrition-examination-surveys-1999-2002
#9
Samson Y Gebreab, Zerai G Manna, Rumana J Khan, Pia Riestra, Ruihua Xu, Sharon K Davis
BACKGROUND: The associations between individual cardiovascular disease risk factors and leukocyte telomere length (LTL) have been inconclusive. We investigated the association between LTL and overall cardiovascular health (CVH) as defined by the American Heart Association and whether the association is modified by sex and race/ethnicity. METHODS AND RESULTS: We included 5194 adults (aged ≥20) from the National Health and Nutrition Examination Survey 1999-2002...
February 2, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28149561/prognostic-significance-of-red-cell-distribution-width-in-elderly-patients-undergoing-resection-for-non-small-cell-lung-cancer
#10
Junji Ichinose, Tomohiro Murakawa, Mitsuaki Kawashima, Kazuhiro Nagayama, Jun-Ichi Nitadori, Masaki Anraku, Jun Nakajima
BACKGROUND: The impact of red cell distribution width (RDW) on outcomes in elderly patients after surgery for non-small cell lung cancer (NSCLC) is not fully understood. METHODS: We retrospectively analyzed 992 NSCLC patients who underwent curative resection between 1998 and 2012. The following variables were included in the analyses to evaluate the role of RDW: age, gender, smoking index, leukocyte count, neutrophil to lymphocyte ratio (NLR), hemoglobin, platelet count, albumin, C-reactive protein, carcinoembryonic antigen, respiratory function, histology, T factor, N factor, surgical approach, surgical procedures, complications and prognosis...
December 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28148585/behcet-s-disease
#11
Jagdish R Nair, Robert J Moots
Behçet's disease (BD) is a chronic relapsing and remitting vasculitis of unknown aetiology. It has the capacity to affect almost all organ systems because of its potential to involve both arteries and veins of all sizes, resulting in significant organ-threatening morbidity and mortality. Traditionally known as the 'silk road' disease, it has a worldwide occurrence. The aetiopathological mechanisms of disease development in BD remain poorly understood, but genome wide studies show human leukocyte antigen and non-human leukocyte antigen associations...
February 2017: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/28147279/endothelial-basement-membrane-laminin-511-contributes-to-endothelial-junctional-tightness-and-thereby-inhibits-leukocyte-transmigration
#12
Jian Song, Xueli Zhang, Konrad Buscher, Ying Wang, Huiyu Wang, Jacopo Di Russo, Lixia Li, Stefan Lütke-Enking, Alexander Zarbock, Anika Stadtmann, Paul Striewski, Benedikt Wirth, Ivan Kuzmanov, Heinz Wiendl, Dörte Schulte, Dietmar Vestweber, Lydia Sorokin
Endothelial basement membranes constitute barriers to extravasating leukocytes during inflammation, a process where laminin isoforms define sites of leukocyte exit; however, how this occurs is poorly understood. In addition to a direct effect on leukocyte transmigration, we show that laminin 511 affects endothelial barrier function by stabilizing VE-cadherin at junctions and downregulating expression of CD99L2, correlating with reduced neutrophil extravasation. Binding of endothelial cells to laminin 511, but not laminin 411 or non-endothelial laminin 111, enhanced transendothelial cell electrical resistance (TEER) and inhibited neutrophil transmigration...
January 31, 2017: Cell Reports
https://www.readbyqxmd.com/read/28146403/hyaluronic-acid-versus-platelet-rich-plasma
#13
Brian J Cole, Vasili Karas, Kristen Hussey, Kyle Pilz, Lisa A Fortier
BACKGROUND: The use of platelet-rich plasma (PRP) for the treatment of osteoarthritis (OA) has demonstrated mixed clinical outcomes in randomized controlled trials when compared with hyaluronic acid (HA), an accepted nonsurgical treatment for symptomatic OA. Biological analysis of PRP has demonstrated an anti-inflammatory effect on the intra-articular environment. PURPOSE: To compare the clinical and biological effects of an intra-articular injection of PRP with those of an intra-articular injection of HA in patients with mild to moderate knee OA...
February 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28143493/the-yin-yan-of-ccl2-a-minor-role-in-neutrophil-anti-tumor-activity-in-vitro-but-a-major-role-on-the-outgrowth-of-metastatic-breast-cancer-lesions-in-the-lung-in-vivo
#14
Nicole Lavender, Jinming Yang, Sheau-Chiann Chen, Jiqing Sai, C Andrew Johnson, Philip Owens, Gregory D Ayers, Ann Richmond
BACKGROUND: The role of the chemokine CCL2 in breast cancer is controversial. While CCL2 recruits and activates pro-tumor macrophages, it is also reported to enhance neutrophil-mediated anti-tumor activity. Moreover, loss of CCL2 in early development enhances breast cancer progression. METHODS: To clarify these conflicting findings, we examined the ability of CCL2 to alter naïve and tumor entrained neutrophil production of ROS, release of granzyme-B, and killing of tumor cells in multiple mouse models of breast cancer...
January 31, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28138440/inverse-correlation-between-cd8-inflammatory-cells-and-e-cadherin-expression-in-gallbladder-cancer-tissue-microarray-and-imaging-analysis
#15
Keita Kai, Masanori Masuda, Shinichi Aishima
AIM: To investigated the association between the tumor cells' expression of E-cadherin and the numbers of several types of inflammatory cells infiltrating into the invasive portion of gallbladder cancer (GBC). METHODS: We analyzed 50 GBC cases for which a sufficient amount of tumor tissues for tissue microarray (TMA) had been saved. Three tissue cores (3.0 mm) of invasive lesion from each case were used for the TMA. The 4-μm cut sections on slides were immunostained using primary antibodies including E-cadherin for cancer cells, leukocyte common antigen for leukocyte, myeloperoxidase for neutrophils, CD3 for T cells, CD4 for helper T cells, CD8 for killer T cells, CD20 for B cells and CD68 for macrophages...
January 16, 2017: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/28134623/a-ccr4-antagonist-reverses-the-tumor-promoting-microenvironment-of-renal-cancer
#16
Chiara Berlato, Moddasar N Khan, Tiziana Schioppa, Richard Thompson, Eleni Maniati, Anne Montfort, Maryam Jangani, Monica Canosa, Hagen Kulbe, Urs B Hagemann, Alexander R Duncan, Laura Fletcher, Robert W Wilkinson, Thomas Powles, Sergio A Quezada, Frances R Balkwill
Elevated expression of the chemokine receptor CCR4 in tumors is associated with poor prognosis in several cancers. Here, we have determined that CCR4 was highly expressed in human renal cell carcinoma (RCC) biopsies and observed abnormal levels of CCR4 ligands in RCC patient plasma. An antagonistic anti-CCR4 antibody had antitumor activity in the RENCA mouse model of RCC. CCR4 inhibition did not reduce the proportion of infiltrating leukocytes in the tumor microenvironment but altered the phenotype of myeloid cells, increased NK cell and Th1 cytokine levels, and reduced immature myeloid cell infiltrate and blood chemokine levels...
January 30, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28129526/addition-of-androgens-improves-survival-in-elderly-patients-with-acute-myeloid-leukemia-a-goelams-study
#17
Arnaud Pigneux, Marie C Béné, Philippe Guardiola, Christian Recher, Jean-Francois Hamel, Mathieu Sauvezie, Jean-Luc Harousseau, Olivier Tournilhac, Francis Witz, Christian Berthou, Martine Escoffre-Barbe, Denis Guyotat, Nathalie Fegueux, Chantal Himberlin, Mathilde Hunault, Martine Delain, Bruno Lioure, Eric Jourdan, Frederic Bauduer, Francois Dreyfus, Jean-Yves Cahn, Jean-Jacques Sotto, Norbert Ifrah
Purpose Elderly patients with acute myeloid leukemia (AML) have a poor prognosis, and innovative maintenance therapy could improve their outcomes. Androgens, used in the treatment of aplastic anemia, have been reported to block proliferation of and initiate differentiation in AML cells. We report the results of a multicenter, phase III, randomized open-label trial exploring the benefit of adding androgens to maintenance therapy in patients 60 years of age or older. Patients and Methods A total of 330 patients with AML de novo or secondary to chemotherapy or radiotherapy were enrolled in the study...
February 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28126521/hs3st1-genotype-regulates-antithrombin-s-inflammomodulatory-tone-and-associates-with-atherosclerosis
#18
Nicole C Smits, Takashi Kobayashi, Pratyaksh K Srivastava, Sladjana Skopelja, Julianne A Ivy, Dustin J Elwood, Radu V Stan, Gregory J Tsongalis, Frank W Sellke, Peter L Gross, Michael D Cole, James T DeVries, Aaron V Kaplan, John F Robb, Scott M Williams, Nicholas W Shworak
The HS3ST1 gene controls endothelial cell production of HS(AT+) - a form of heparan sulfate containing a specific pentasaccharide motif that binds the anticoagulant protein antithrombin (AT). HS(AT+) has long been thought to act as an endogenous anticoagulant; however, coagulation was normal in Hs3st1(-/-) mice that have greatly reduced HS(AT+) (HajMohammadi et al., 2003). This finding indicates that HS(AT+) is not essential for AT's anticoagulant activity. To determine if HS(AT+) is involved in AT's poorly understood inflammomodulatory activities, Hs3st1(-/-) and Hs3st1(+/+) mice were subjected to a model of acute septic shock...
January 23, 2017: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/28122903/ischemic-lesions-blood-pressure-dysregulation-and-poor-outcomes-in-intracerebral-hemorrhage
#19
Chelsea S Kidwell, Jonathan Rosand, Gina Norato, Simone Dixon, Bradford B Worrall, Michael L James, Mitchell S V Elkind, Matthew L Flaherty, Jennifer Osborne, Anastasia Vashkevich, Carl D Langefeld, Charles J Moomaw, Daniel Woo
OBJECTIVE: To evaluate the associations among diffusion-weighted imaging (DWI) lesions, blood pressure (BP) dysregulation, MRI markers of small vessel disease, and poor outcome in a large, prospective study of primary intracerebral hemorrhage (ICH). METHODS: The Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) study is a multicenter, observational study of ICH among white, black, and Hispanic patients. RESULTS: Of 600 patients, mean (±SD) age was 60...
January 25, 2017: Neurology
https://www.readbyqxmd.com/read/28119528/outcomes-of-ucb-transplantation-are-comparable-in-flt3-aml-results-of-cibmtr-eurocord-and-ebmt-collaborative-analysis
#20
C Ustun, F Giannotti, M-J Zhang, H-L Wang, C Brunstein, M Labopin, V Rocha, M de Lima, F Baron, B M Sandmaier, M Eapen, E Gluckman, A Nagler, D J Weisdorf, A Ruggeri
Allogeneic hematopoietic cell transplantation (HCT) from siblings or unrelated donors (URD) during complete remission (CR) may improve leukemia-free survival (LFS) in FLT3+ acute myeloid leukemia (AML) that has poor prognosis due to high relapse rates. Umbilical cord blood (UCB) HCT outcomes are largely unknown in this population. We found that compared with sibling HCT, relapse risks were similar after UCB (n=126), (HR 0.86, P=0.54) and URD (n=91) (HR 0.81, P=0.43). UCB HCT was associated with statistically higher non-relapse mortality compared with sibling HCT (HR 2...
January 25, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
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