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https://www.readbyqxmd.com/read/28454377/frequent-expression-of-human-leukocyte-antigen-class-i-and-the-status-of-intratumoral-immune-cells-in-alveolar-soft-part-sarcoma
#1
Akira Ogose, Hiroyuki Kawashima, Tetsuo Hotta, Takashi Ariizumi, Tetsuro Yamagishi, Naoki Oike, Taro Sasaki, Hiroshi Hatano, Hajime Umezu, Naoto Endo
The prognosis of alveolar soft part sarcoma is poor, despite the slow growth of the tumor. A number of cases with spontaneous regression of this rare tumor have been reported. Although the mechanisms underlying spontaneous regression remain uncertain, local immune reaction may be a possible contributing factor. Immunohistochemical expression of human leukocyte antigen (HLA) class I, cluster of differentiation (CD) 3, CD4, CD8, CD20, CD45, CD56, CD68, CD138 and CD163 were assessed in a series of 10 alveolar soft part sarcomas, and the expression profiles were associated with patients' clinicopathological parameters...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28433655/targeting-sarcoma-tumor-initiating-cells-through-differentiation-therapy
#2
Dan Han, Veronica Rodriguez-Bravo, Elizabeth Charytonowicz, Elizabeth Demicco, Josep Domingo-Domenech, Robert G Maki, Carlos Cordon-Cardo
Human leukocyte antigen class I (HLA-I) down-regulation has been reported in many human cancers to be associated with poor clinical outcome. However, its connection to tumor-initiating cells (TICs) remains unknown. In this study, we report that HLA-I is down-regulated in a subpopulation of cells that have high tumor initiating capacity in different types of human sarcomas. Detailed characterization revealed their distinct molecular profiles regarding proliferation, apoptosis and stemness programs. Notably, these TICs can be induced to differentiate along distinct mesenchymal lineages, including the osteogenic pathway...
April 13, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28427856/frizzled-3-acts-upstream-of-alcam-during-embryonic-eye-development
#3
Franziska A Seigfried, Wiebke Cizelsky, Astrid S Pfister, Petra Dietmann, Paul Walther, Michael Kühl, Susanne J Kühl
Formation of a functional eye during vertebrate embryogenesis requires different processes such as cell migration, cell-cell interactions as well as intracellular signalling processes. It was previously shown that the non-canonical Wnt receptor Frizzled 3 (Fzd3) is required for proper eye formation, however, the underlying mechanism is poorly understood. Here we demonstrate that loss of Fzd3 induces severe malformations of the developing eye and that this defect is phenocopied by loss of the activated leukocyte cell adhesion molecule (Alcam)...
April 17, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28424689/antimicrobial-and-attractant-roles-for-chemerin-in-the-oral-cavity-during-inflammatory-gum-disease
#4
Urszula Godlewska, Piotr Brzoza, Aneta Sroka, Pawel Majewski, Holger Jentsch, Martin Eckert, Sigrun Eick, Jan Potempa, Brian A Zabel, Joanna Cichy
Periodontal inflammation is one of the most common chronic inflammatory conditions in humans. Despite recent advances in identifying and characterizing oral microbiota dysbiosis in the pathogenesis of gum disease, just how host factors maintain a healthy homeostatic oral microbial community or prevent the development of a pathogenic oral microbiota remains poorly understood. An important determinant of microbiota fate is local antimicrobial proteins. Here, we report that chemoattractant protein chemerin, which we recently identified as a potent endogenous antimicrobial agent in body barriers such as the skin, is present in the oral cavity under homeostatic and inflammatory conditions...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28422768/mechanisms-involved-in-secondary-cardiac-dysfunction-in-animal-models-of-trauma-and-haemorrhagic-shock
#5
Nick M Wilson, Johanna Wall, Veena Naganathar, Karim Brohi, Henry D De'Ath
Clinical evidence reveals the existence of a trauma induced secondary cardiac injury (TISCI) which is associated with poor patient outcomes. The mechanisms leading to TISCI in injured patients are uncertain. Conversely, animal models of trauma haemorrhage have repeatedly demonstrated significant cardiac dysfunction following injury, and highlighted mechanisms through which this might occur. The aim of this review was to provide an overview of the animal studies describing TISCI and its pathophysiology.Basic science models of trauma show evidence of innate immune system activation via Toll-Iike receptors (TLRs), the exact protagonists of which remain unclear...
April 18, 2017: Shock
https://www.readbyqxmd.com/read/28420863/changes-of-systemic-immune-response-after-stereotactic-ablative-radiotherapy-sabr-first-results-of-a-prospective-study-in-early-lung-cancer-patients
#6
Jacek Rutkowski, Tomasz Ślebioda, Zbigniew Kmieć, Renata Zaucha
INTRODUCTION    Among all lung tumors non-small cell lung cancer (NSCLC) is the most common. Conventional conservative treatment in medically inoperable patients with early stage NSCLC has a poor outcome. To improve treatment efficacy stereotactic ablative radiotherapy (SABR) has been developed to enable the delivery of high-dose radiation to the tumor.  OBJECTIVES    This prospective study was conducted to confirm the hypothesis that a sudden death of cancer cells after SABR may lead to systemic immune response changes...
April 18, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28416261/feasibility-study-of-personalized-peptide-vaccination-for-advanced-small-cell-lung-cancer
#7
Shinjiro Sakamoto, Teppei Yamada, Yasuhiro Terazaki, Koichi Yoshiyama, Shunichi Sugawara, Shinzo Takamori, Satoko Matsueda, Shigeki Shichijo, Akira Yamada, Masanori Noguchi, Kyogo Itoh, Noboru Hattori, Nobuoki Kohno, Tetsuro Sasada
INTRODUCTION: The prognosis of patients with small cell lung cancer (SCLC) remains very poor. Therefore, the development of new therapeutic approaches, including immunotherapies, is desirable. PATIENTS AND METHODS: We conducted a phase II study of personalized peptide vaccination (PPV), in which a maximum of 4 human leukocyte antigen-matched peptides were selected from 31 pooled peptides according to the pre-existing peptide-specific IgG responses before vaccination...
March 24, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28410235/cysteinyl-leukotriene-receptor-1-facilitates-tumorigenesis-in-a-mouse-model-of-colitis-associated-colon-cancer
#8
Janina Osman, Sayeh Savari, Naveen Kumar Chandrashekar, Kishan Bellamkonda, Desiree Douglas, Anita Sjölander
Cysteinyl leukotriene receptor 1 (CysLT1R) has been shown to be up-regulated in the adenocarcinomas of colorectal cancer patients, which is associated with a poor prognosis. In a spontaneous model of colon cancer, CysLT1R disruption was associated with a reduced tumor burden in double-mutant female mice (ApcMin/+/Cysltr1-/-) compared to ApcMin/+ littermates. In the current study, we utilized a genetic approach to investigate the effect of CysLT1R in the induced azoxymethane/dextran sulfate sodium (AOM/DSS) model of colitis-associated colon cancer...
March 30, 2017: Oncotarget
https://www.readbyqxmd.com/read/28387674/psychotic-symptoms-associated-with-poor-renal-function-in-mild-cognitive-impairment-and-dementias
#9
Ralf Kunschmann, Stefan Busse, Thomas Frodl, Mandy Busse
Patients suffering from cognitive decline such as mild cognitive impairment or neurodegenerative disorders including Alzheimer's dementia, vascular dementia, frontotemporal dementia, and Lewy body dementia are often accompanied by symptoms like psychosis, depression, agitation, and apathy. Aging increases not only the prevalence of dementia but also the development of kidney disorders, which had emerged as possible risk factor of cognitive impairment and dementia. However, a contribution of renal dysfunction to psychosis associated with cognitive decline remains to be investigated...
April 3, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28382715/platelet-donor-selection-for-hla-immunised-patients-the-impact-of-donor-specific-hla-antibody-levels
#10
T Linjama, R Niittyvuopio, J Tuimala, M Pyörälä, H Rintala, J Rimpiläinen, M Kauppila, J Peräsaari, E Juvonen
BACKGROUND: Approximately 20% of patients with a recurrently poor platelet transfusion increment show human leukocyte antigen (HLA) alloantibodies. The aim of this study was to analyse the impact of mean fluorescence intensity (MFI) levels of donor-specific HLA antibodies and the feasibility of the HLAMatchmaker algorithm in donor selection. STUDY DESIGN AND METHODS: A total of 270 HLA-typed platelet transfusion responses of 40 patients were included in the study...
April 6, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28376564/adipogenic-differentiation-of-mesenchymal-stem-cells-alters-their-immunomodulatory-properties-in-a-tissue-specific-manner
#11
Hafsa Munir, Lewis S C Ward, Lozan Sheriff, Samuel Kemble, Saba Nayar, Francesca Barone, Gerard B Nash, Helen M McGettrick
Chronic inflammation is associated with formation of ectopic fat deposits that might represent damage-induced aberrant mesenchymal stem cell (MSC) differentiation. Such deposits are associated with increased levels of inflammatory infiltrate and poor prognosis. Here we tested the hypothesis that differentiation from MSC to adipocytes in inflamed tissue might contribute to chronicity through loss of immunomodulatory function. We assessed the effects of adipogenic differentiation of MSC isolated from bone marrow or adipose tissue on their capacity to regulate neutrophil recruitment by endothelial cells and compared the differentiated cells to primary adipocytes from adipose tissue...
April 4, 2017: Stem Cells
https://www.readbyqxmd.com/read/28375975/autologous-pure-platelet-rich-plasma-dermal-injections-for-facial-skin-rejuvenation-clinical-instrumental-and-flow-cytometry-assessment
#12
Norma Cameli, Maria Mariano, Iole Cordone, Elva Abril, Serena Masi, Maria Laura Foddai
BACKGROUND: Platelet-rich plasma (PRP) is an emerging treatment in dermatology recently proposed for skin rejuvenation. OBJECTIVE: To evaluate the efficacy and safety of autologous pure PRP dermal injections on facial skin rejuvenation, investigating the cellularity of PRP samples. MATERIALS AND METHODS: Twelve patients underwent 3 sessions of PRP injection at 1-month intervals. The clinical and instrumental outcomes were evaluated before (T0) and 1 month (T1) after the end of treatment by means of transepidermal water loss, corneometry, Cutometer, Visioscan, and Visioface...
April 3, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28373473/telomere-length-in-leukocyte-dna-in-gastric-cancer-patients-and-its-association-with-clinicopathological-features-and-prognosis
#13
Tomomitsu Tahara, Sayumi Tahara, Noriyuki Horiguchi, Tomohiko Kawamura, Masaaki Okubo, Takamitsu Ishizuka, Hyuga Yamada, Dai Yoshida, Takafumi Ohmori, Kohei Maeda, Naruomi Komura, Hirokazu Ikuno, Yasutaka Jodai, Toshiaki Kamano, Mitsuo Nagasaka, Yoshihito Nakagawa, Tetsuya Tuskamoto, Makoto Urano, Tomoyuki Shibata, Makoto Kuroda, Naoki Ohmiya
BACKGROUND/AIM: Telomere shortening in leukocytes has been thought to be associated with reduced immune response capacity and increased chromosome instability. Several studies indicate that telomere length in the peripheral blood leukocyte DNA can predict clinical outcome of several cancers. We evaluated the potential association between telomere shortening in the leukocyte DNA and clinicopathological features and prognosis of gastric cancer (GC) in Japanese patients. MATERIALS AND METHODS: Telomere length in leukocyte DNA was measured using quantitative real-time polymerase chain reaction (PCR) in 207 GC patients...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/28372797/unique-high-and-homogenous-surface-expression-of-the-transferrin-receptor-cd71-on-murine-plasmacytoid-dendritic-cells-in-different-tissues
#14
Anne Lippitsch, Yuri Chukovetskyi, Nelli Baal, Gregor Bein, Holger Hackstein
Plasmacytoid dendritic cells (pDC) are of increasing interest in cancer vaccine development, but many functions of these highly specialized, multifaceted cells are poorly understood. The transferrin receptor CD71 has also been suggested to function as an antigen uptake receptor on professional antigen-presenting cells. In this study, we employed multiparameter flow cytometry to investigate CD71 expression on various leukocyte subsets, including DC subsets, granulocytes, macrophages, T and B lymphocytes, γδ T cells, and natural killer cells...
March 29, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/28363494/clinical-and-endoscopic-features-in-patients-with-hospital-acquired-diarrhea-associated-with-clostridium-difficile-infection
#15
J A Velarde Ruiz-Velasco, J M Aldana-Ledesma, M A Ibarra-Estrada, S A Aguirre Díaz, J A Fernández-Ramírez, F Cárdenas-Lara, F Álvarez López, L E Rodríguez-Noriega, H R Pérez-Gómez, M R Morfín-Otero
BACKGROUND AND AIMS: Clostridium difficile (CD) is the leading cause of hospital-acquired diarrhea. Clinical and endoscopic findings are poorly described in our country. The aim of this study is to depict those findings. MATERIAL AND METHODS: Prospective cohort study, which included patients with CD associated hospital-acquired diarrhea, diagnosed by means of fecal PCR and testing for the presence of hypervirulent strain NAP027. We analyzed clinical and endoscopic features, as well as the variables associated with severe disease...
March 28, 2017: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/28361055/changes-in-circulating-monocyte-subsets-cd16-expression-and-neutrophil-to-lymphocyte-ratio-observed-in-patients-undergoing-cardiac-surgery
#16
Kareem Gawdat, Stephanie Legere, Chloe Wong, Tanya Myers, Jean Sylvia Marshall, Ansar Hassan, Keith R Brunt, Petra C Kienesberger, Thomas Pulinilkunnil, Jean-Francois Legare
BACKGROUND: The characteristics of circulating inflammatory cells (leukocytes) in patients undergoing heart surgery remains poorly understood. Recently, neutrophil-to-lymphocyte ratio (NLR) and specific monocyte subsets (based on CD14/CD16 expression) have been suggested as markers of inflammation and predictors of outcomes. The present study aims to characterize the influence cardiac surgery with cardiopulmonary bypass has on specific circulating leukocytes. METHODS: All enrolled patients had blood samples taken pre- (0 days), early post- (5 days), and late post- (90 days) surgery...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28357111/typing-of-killer-cell-immunoglobulin-like-receptors-and-their-cognate-human-leukocyte-antigen-class-i-ligands-predicts-survival-of-chinese-han-patients-with-metastatic-non-small-cell-lung-cancer
#17
Hui Yu, Fang Liu, Benoit Sansas, Bin Kang, Xavier Preville, Xianghua Wu, Jianhua Chang, Romain Micol, Jialei Wang, Xia Meng
Non-small-cell lung cancer (NSCLC) may establish an immunosuppressive tumor microenvironment that is conducive to tumor growth. Natural killer (NK) cells play a pivotal role in immunological surveillance. Activation of NK cells partially depends on the interactions between killer-cell immunoglobulin-like receptors (KIRs) and human leukocyte antigen (HLA) class I ligands. We herein investigated the association of KIRs and HLA ligands with survival in metastatic NSCLC (mNSCLC) patients treated with chemotherapy in a Chinese Han population...
February 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28356347/leukocyte-phosphodiesterase-expression-after-lipopolysaccharide-and-during-sepsis-and-its-relationship-with-hla-dr-expression
#18
Christophe Lelubre, Hayfa Medfai, Israa Akl, Jenneke Leentjens, Matthijs Kox, Peter Pickkers, Alexandre Rousseau, Patrick Biston, Michael Piagnerelli, Michel Vanhaeverbeek, Pierrick Uzureau, Jean-Louis Vincent, Luc Vanhamme, Karim Zouaoui Boudjeltia
Phosphodiesterases (PDEs) may modulate inflammatory pathways, but PDE expression is poorly documented in humans with sepsis. Using quantitative PCR on whole blood leukocytes, we characterized PDE mRNA expression in healthy volunteers (n = 20), healthy volunteers given lipopolysaccharide (LPS; n = 18), and critically ill patients with (n = 20) and without (n = 20) sepsis. PDE4B protein expression was also studied in magnetic-activated cell sorting (MACS)-isolated CD15(+) neutrophils (from 7 healthy volunteers, 5 patients without and 5 with sepsis)...
March 29, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28351617/interaction-of-fam5c-with-udp-glucose-glycoprotein-glucosyltransferase-1-uggt1-implication-of-n-glycosylation-in-fam5c-secretion
#19
Yuya Terao, Hidenobu Fujita, Sayo Horibe, Junya Sato, Satomi Minami, Miwako Kobayashi, Ichiro Matsuoka, Naoto Sasaki, Seimi Satomi-Kobayashi, Ken-Ichi Hirata, Yoshiyuki Rikitake
N-glycosylation of proteins is important for protein folding and function. We have recently reported that FAM5C/BRINP3 contributes to the tumor necrosis factor-α-induced expression of leukocyte adhesion molecules in vascular endothelial cells (ECs). However, regulatory mechanism of the FAM5C biosynthesis is poorly understood. Co-immunoprecipitation assay revealed the interaction of FAM5C with UDP-glucose:glycoprotein glucosyltransferase 1 (UGGT1), a glycoprotein folding-sensor enzyme. FAM5C ectopically expressed in HEK293 cells was localized to the endoplasmic reticulum and co-localized with endogenously expressed UGGT1...
March 27, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28345834/hyperuricemia-at-the-time-of-diagnosis-is-a-factor-for-poor-prognosis-in-patients-with-stage-ii-and-iii-colorectal-cancer-uric-acid-and-colorectal-cancer
#20
Ahmet Ozan Cetin, Muhyettin Omar, Serkan Calp, Hasan Tunca, Nevin Yimaz, Burak Ozseker, Ozgur Tanriverdi
Purpose: In this pilot study we investigated whether serum levels of uric acid, the final breakdown product of purine metabolism, might influence cancer-related events in stage II and III colorectal cancer patients. Material and methods: In this cross-sectional retrospective study, a total of 150 stage II and III colorectal adenocarcinoma patients with no exclusion criteria were included. Serum uric acid levels of the patients measured at diagnosis and demographic, clinical, laboratory analyses were performed and histologically features recorded...
February 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
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