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https://www.readbyqxmd.com/read/29788904/genetic-diversity-of-bola-drb3-in-south-american-zebu-cattle-populations
#1
Shin-Nosuke Takeshima, Claudia Corbi-Botto, Guillermo Giovambattista, Yoko Aida
BACKGROUND: Bovine leukocyte antigens (BoLAs) are used extensively as markers of disease and immunological traits in cattle. However, until now, characterization of BoLA gene polymorphisms in Zebu breeds using high resolution typing methods has been poor. Here, we used a polymerase chain reaction sequence-based typing (PCR-SBT) method to sequence exon 2 of the BoLA class II DRB3 gene from 421 cattle (116 Bolivian Nellore, 110 Bolivian Gir, and 195 Peruvian Nellore-Brahman). Data from 1416 Taurine and Zebu samples were also included in the analysis...
May 22, 2018: BMC Genetics
https://www.readbyqxmd.com/read/29788362/similar-inhibition-of-dynamic-adhesion-of-lymphocytes-from-ibd-patients-to-madcam-1-by-vedolizumab-and-etrolizumab-s
#2
Marie-Theres Binder, Emily Becker, Maximilian Wiendl, Lena Schleier, Friederike Fuchs, Moritz Leppkes, Raja Atreya, Clemens Neufert, Imke Atreya, Markus F Neurath, Sebastian Zundler
Background: Although anti-adhesion therapies are a novel mainstay in the treatment of inflammatory bowel diseases (IBDs), the mechanisms controlling integrin-dependent gut homing are poorly elucidated, and the available techniques for translational functional investigations are limited. Methods: We used dynamic adhesion assays to study adhesion of CD4+ T cells, CD8+ T cells, CD19+ B cells, and granulocytes to the addressins MAdCAM-1, VCAM-1, and ICAM-1. The effects of vedolizumab, natalizumab, etrolizumab-s, anti-CD11a, and anti-CD18 antibodies were explored...
May 18, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29787979/genome-wide-analysis-reveals-tnfaip8l2-as-an-immune-checkpoint-regulator-of-inflammation-and-metabolism
#3
Ting Li, Wei Wang, Shunyou Gong, Honghong Sun, Huqin Zhang, An-Gang Yang, Youhai H Chen, Xinyuan Li
The interplay between inflammation and metabolism is widely recognized, yet the underlying molecular mechanisms remain poorly characterized. Using experimental database mining and genome-wide gene expression profiling methods, we found that in contrast to other TNFAIP8 family members, TNFAIP8L2 (TIPE2) was preferentially expressed in human myeloid cell types. In addition, Tnfaip8l2 expression drastically decreased in lipopolysaccharide (LPS)-stimulated macrophages. Consequently, Tnfaip8l2 deficiency led to heightened expression of genes that were enriched for leukocyte activation and lipid biosynthesis pathways...
May 19, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29786040/human-leukocyte-antigen-a-allele-distribution-in-nasopharyngeal-carcinoma-patients-showing-anti-melanoma-associated-antigen-a-or-synovial-sarcoma-x-2-t-cell-response-in-blood
#4
Pei-Wen Fan, Li Huang, Xue-Mei Chang, Ya-Ning Feng, Xuan Yao, Yan-Chun Peng, Tao Dong, Ruo-Zheng Wang
Background: Development of innovative immunotherapy is imperative to improve the poor survival of the nasopharyngeal carcinoma (NPC) patients. In this study, we evaluated the T cell response to melanoma-associated antigen (MAGE)-A1, MAGE-A3, or synovial sarcoma X-2 (SSX-2) in the peripheral blood of treatment-naive NPC patients. The relationship of responses among the three proteins and the human leukocyte antigen (HLA)-A types were analyzed to provide evidence of designing novel therapy...
June 5, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29782541/an-unappreciated-role-for-neutrophil-dc-hybrids-in-immunity-to-invasive-fungal-infections
#5
J Scott Fites, Michael Gui, John F Kernien, Paige Negoro, Zeina Dagher, David B Sykes, Jeniel E Nett, Michael K Mansour, Bruce S Klein
Neutrophils are classically defined as terminally differentiated, short-lived cells; however, neutrophils can be long-lived with phenotypic plasticity. During inflammation, a subset of neutrophils transdifferentiate into a population called neutrophil-DC hybrids (PMN-DCs) having properties of both neutrophils and dendritic cells. While these cells ubiquitously appear during inflammation, the role of PMN-DCs in disease remains poorly understood. We observed the differentiation of PMN-DCs in pre-clinical murine models of fungal infection: blastomycosis, aspergillosis and candidiasis...
May 21, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29782187/effects-of-maternal-vitamin-d-supplementation-on-the-maternal-and-infant-epigenome
#6
Cindy M Anderson, Shannon L Gillespie, Doria K Thiele, Jody L Ralph, Joyce E Ohm
INTRODUCTION: Mothers and infants are at high risk for inadequate vitamin D status. Mechanisms by which vitamin D may affect maternal and infant DNA methylation are poorly understood. OBJECTIVE: This study quantified the effects of vitamin D3 supplementation on DNA methylation in pregnant and lactating women and their breastfed infants. MATERIALS AND METHODS: In this randomized controlled pilot study, pregnant women received vitamin D3 400 international units (IU) (n = 6; control) or 3,800 IU (n = 7; intervention) daily from late second trimester through 4-6 weeks postpartum...
May 21, 2018: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/29781781/gene-expression-microarray-analysis-reveals-prognostic-markers-of-survival-in-high-grade-astrocytomas
#7
Jun Yang, Ziming Hou, Changjiang Wang, Hao Wang, Hongbing Zhang
OBJECTIVE: High grade astrocytoma (HGA) as an aggressive brain tumor, is always correlated with poor prognosis. In this paper, we aimed to explore the genetic prognostic biomarkers for HGA. METHODS: The genome-wide expression profile of 26 brain tumor samples obtained from 26 patients with HGA was downloaded from Gene Expression Omnibus. The risk genes for prognosis of HGA were identified and verified by the data in TCGA database. Protein-protein interaction (PPI) network of risk factor genes was constructed and significant module was screened...
May 21, 2018: Neurological Research
https://www.readbyqxmd.com/read/29776612/immunohistochemical-investigation-of-the-cross-reactivity-of-selected-cell-markers-in-formalin-fixed-paraffin-embedded-lymphoid-tissues-of-franciscana-pontoporia-blainvillei
#8
J Díaz-Delgado, R Ressio, K R Groch, J L Catão-Dias
A considerable amount of knowledge on natural and anthropogenic pathologic conditions affecting different cetacean species has been gained over the last decades. Nonetheless, the immunopathological bases for most of these processes have been poorly documented or remain unknown. Comparative immunopathological investigations in these species are precluded by the limited number of specific antibodies, most of which are not commercially available, and the reduced spectrum of validated and/or cross-reactive ones...
June 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29776595/clinicopathologic-significance-of-lair-1-expression-in-hepatocellular-carcinoma
#9
Xiaojie Wu, Leyan Zhang, Jiadi Zhou, Luying Liu, Qiang Fu, Aili Fu, Xiaoying Feng, Rui Xin, Hongrui Liu, Yong Gao, Jiangnan Xue
AIM: Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is an immune inhibitory receptor which is expressed within most types of hematopoietic cells and negatively regulates immune responses. Recently, we found LAIR-1 expression to be present within tumors of nonhematopoietic lineages. However, the roles of LAIR-1 in hepatocellular carcinoma (HCC) have yet to be examined. The purpose of this study was to investigate the expression of LAIR-1 in HCC tissue and assess its clinical significance at this site...
April 30, 2018: Current Problems in Cancer
https://www.readbyqxmd.com/read/29765514/wnt5a-induced-cell-migration-is-associated-with-the-aggressiveness-of-estrogen-receptor-positive-breast-cancer
#10
Yoshie Kobayashi, Takayuki Kadoya, Ai Amioka, Hideaki Hanaki, Shinsuke Sasada, Norio Masumoto, Hideki Yamamoto, Koji Arihiro, Akira Kikuchi, Morihito Okada
Elevated expression of Wnt5a is associated with malignancy, cell invasion, and metastasis. The role of Wnt5a expression in breast cancer remains elusive. We investigated the significance of Wnt5a expression in breast cancer. The relationship between Wnt5a expression and clinicopathologic factors was assessed in invasive breast cancer ( n = 178) resected at Hiroshima University Hospital between January 2011 and February 2014. Wnt5a was expressed in 69 of 178 cases (39%) of invasive breast cancer and correlated strongly with estrogen receptor (ER) expression ( P < 0...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29763480/spontaneous-regression-of-merkel-cell-carcinoma
#11
Sean Branch, Kenneth Maloney, Stephen M Purcell
A 96-year-old woman presented with a rapidly enlarging lesion overlying the suprasternal notch. The lesion originated as a small, erythematous, scaly macule that rapidly increased in size over 8 weeks and became an ulcerated nodule measuring 5 cm in diameter and 4.5 cm in thickness. A 4-mm punch biopsy showed a poorly differentiated tumor with cells that were positive for CAM 5.2 and cytokeratin 20 in a dotlike paranuclear pattern and negative for cytokeratin 5/6, human melanoma black 45, and leukocyte common antigen...
April 2018: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29758111/genetic-profiles-of-transcriptomic-clusters-of-childhood-asthma-determine-specific-severe-subtype
#12
Y-L Yeh, M-W Su, B-L Chiang, Y-H Yang, C-H Tsai, Y L Lee
BACKGROUND: Previous studies have defined transcriptomic subtypes of adult asthma using samples of induced sputum and bronchial epithelium; however, those procedures are not readily applicable in the clinic, especially for childhood asthma. OBJECTIVE: We aim to dissect the transcriptomic clusters of childhood asthma using highly variably expressed genes of peripheral blood mononuclear cells (PBMC) among patients. METHODS: Gene expression of PBMC from 133 asthmatic children and 11 healthy controls was measured with Illumina microarrays...
May 14, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29752550/aging-alters-the-immunological-response-to-ischemic-stroke
#13
Rodney M Ritzel, Yun-Ju Lai, Joshua D Crapser, Anita R Patel, Anna Schrecengost, Jeremy M Grenier, Nickolas S Mancini, Anthony Patrizz, Evan R Jellison, Diego Morales-Scheihing, Venugopal R Venna, Julia K Kofler, Fudong Liu, Rajkumar Verma, Louise D McCullough
The peripheral immune system plays a critical role in aging and in the response to brain injury. Emerging data suggest inflammatory responses are exacerbated in older animals following ischemic stroke; however, our understanding of these age-related changes is poor. In this work, we demonstrate marked differences in the composition of circulating and infiltrating leukocytes recruited to the ischemic brain of old male mice after stroke compared to young male mice. Blood neutrophilia and neutrophil invasion into the brain were increased in aged animals...
May 11, 2018: Acta Neuropathologica
https://www.readbyqxmd.com/read/29750676/human-leukocyte-antigen-matching-in-organ-transplantation-what-we-know-and-how-can-we-make-it-better-revisiting-the-past-improving-the-future
#14
Anat R Tambur
PURPOSE OF REVIEW: A renaissance for human leukocyte antigen (HLA) testing emerged with the understanding that donor-specific HLA antibodies play a significant role in long-term allograft survival. This renewed focus on donor/recipient histocompatibility led to a recent quest to decipher antibody responses or, as introduced into the transplantation lexicon, 'HLA-epitope matching'. RECENT FINDINGS: Whether matching is at the antigen or the epitope level, in-depth understanding of how histo-incompatibility leads to activation of an immune response is required...
May 9, 2018: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/29750504/c1q-mediated-complement-activation-and-c3-opsonization-trigger-recognition-of-stealth-poly-2-methyl-2-oxazoline-coated-silica-nanoparticles-by-human-phagocytes
#15
Regina Tavano, Luca Gabrielli, Elisa Lubian, Chiara Fedeli, Silvia Visentin, Patrizia Polverino de Laureto, Giorgio Arrigoni, Alessandra Geffner-Smith, Fangfang Chen, Dmitri Simberg, Giulia Morgese, Edmondo Maria Benetti, Linping Wu, Seyed Moein Moghimi, Fabrizio Mancin, Emanuele Papini
Poly(2-methyl-2-oxazoline) (PMOXA) is an alternative promising polymer to poly(ethylene glycol), (PEG), for design and engineering of macrophage-evading nanoparticles (NPs). Although PMOXA engineered NPs have shown comparable pharmacokinetics, and in vivo performance to PEGylated stealth NPs in the murine model, its interaction with elements of the human innate immune system has not been studied. From a translational angle, we studied the interaction of fully characterized PMOXA-coated vinyl-triethoxysilane-derived organically modified silica NPs (PMOXA-coated NPs) of approximately 100 nm in diameter with human complement system, blood leukocytes and macrophages, and compared their performance with PEGylated and uncoated NP counterparts...
May 11, 2018: ACS Nano
https://www.readbyqxmd.com/read/29747640/fibrocytes-are-increased-in-lung-and-peripheral-blood-of-patients-with-idiopathic-pulmonary-fibrosis
#16
P Heukels, J A C van Hulst, M van Nimwegen, C E Boorsma, B N Melgert, L M van den Toorn, K A T Boomars, M S Wijsenbeek, H Hoogsteden, J H von der Thüsen, R W Hendriks, M Kool, B van den Blink
BACKGROUND: Fibrocytes are implicated in Idiopathic Pulmonary Fibrosis (IPF) pathogenesis and increased proportions in the circulation are associated with poor prognosis. Upon tissue injury, fibrocytes migrate to the affected organ. In IPF patients, circulating fibrocytes are increased especially during exacerbations, however fibrocytes in the lungs have not been examined. Therefore, we sought to evaluate if fibrocytes can be detected in IPF lungs and we compare percentages and phenotypic characteristics of lung fibrocytes with circulating fibrocytes in IPF...
May 10, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29740050/matrix-metalloproteinases-mmps-mediate-leukocyte-recruitment-during-the-inflammatory-phase-of-zebrafish-heart-regeneration
#17
Shisan Xu, Sarah E Webb, Terrence Chi Kong Lau, Shuk Han Cheng
In zebrafish, the role of matrix metalloproteinases (MMPs) in the inflammatory phase of heart regeneration following cryoinjury remains poorly understood. Here, we demonstrated an increase in MMP enzymatic activity and elevated expression of mmp9 and mmp13 in the injured area (IA) of hearts from as early as 1 day post-cryoinjury (dpc). Treatment with the broad-spectrum MMP inhibitor, GM6001, during the first week after cryoinjury resulted in impaired heart regeneration, as indicated by the larger scar and reduced numbers of proliferating cardiomyocytes...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29734352/role-of-matrix-metalloproteinases-2-and-9-toll-like-receptor-4-and-platelet-leukocyte-aggregate-formation-in-sepsis-associated-thrombocytopenia
#18
Caroline M Larkin, Nadhim Kamil Hante, Eamon P Breen, Krzysztof A Tomaszewski, Simon Eisele, Marek W Radomski, Thomas A Ryan, Maria-Jose Santos-Martinez
BACKGROUND: The development of thrombocytopenia in sepsis is a poor prognostic indicator associated with a significantly increased mortality risk. Mechanisms underlying this phenomenon remain to be clearly elucidated. Matrix metalloproteinases (MMPs) are enzymes that regulate the turnover of the extra-cellular matrix. MMP-2 is recognised as a platelet agonist with MMP-9 proposed as an inhibitor of platelet activation. The existence of MMP-9 in platelets is a subject of debate. There is limited evidence thus far to suggest that toll-like receptor 4 (TLR-4) and platelet-leukocyte aggregate (PLA) formation may be implicated in the development of sepsis-associated thrombocytopenia...
2018: PloS One
https://www.readbyqxmd.com/read/29731605/the-combination-of-anti-kir-monoclonal-antibodies-with-anti-pd-1-pd-l1-monoclonal-antibodies-could-be-a-critical-breakthrough-in-overcoming-tumor-immune-escape-in-nsclc
#19
Yayi He, Sangtian Liu, Jane Mattei, Paul A Bunn, Caicun Zhou, Daniel Chan
Background: The anti-programmed death-1 (PD-1)/programmed death ligand-1 (PD-L1) monoclonal antibody has a good effect in the treatment of non-small cell lung cancer (NSCLC), but not all PD-1/PD-L1 positive patients can get benefit from it. Compensatory expression of other immune checkpoints may be correlated with the poor efficacy of anti-PD-1/PD-L1 monoclonal antibodies. The inhibitory human leukocyte antigen (HLA)/killer cell Ig-like receptor (KIR) can effectively block the killing effect of natural killer (NK) cells on tumors...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29725279/serum-concentrations-of-soluble-s-l-and-s-p-selectins-in-women-with-ovarian-cancer
#20
Dominika B Majchrzak-Baczmańska, Ewa Głowacka, Miłosz Wilczyński, Andrzej Malinowski
Introduction: The aim of the study was to compare serum concentration of soluble L- and P-selectins in women with ovarian cancer (OC) and healthy controls, and to investigate sL- and sP-selectin levels with regard to clinical and pathological parameters. Correlation analysis was used to measure the following: sL- and sP-selectin concentration and Ca125; sP-selectin and platelet concentrations; and sL-selectin and serum leukocyte levels in women with OC. Material and methods: The study included 29 patients with OC and 23 healthy controls...
March 2018: Przeglad Menopauzalny, Menopause Review
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